Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM)
Université Libre de Bruxelles (ULB)
Campus ERASME
808 route de Lennik
1070 Brussels, BELGIUM
Building C, Level + 5, Room 125/127
Email: jysping@ulb.ac.be
Tel: 32-2-555.41.98
Fax: 32-2-555.46.55
 | jyspring@ulb.ac.be |
Jean-Yves Springael, PhD
Tenured lecturer, Principal Investigator (Université Libre de Bruxelles)
Research topic:
G-protein coupled receptors (GPCRs) constitute one of the largest family of cell surface proteins in vertebrates and invertebrates. They play a wide range of physiological functions like sensory perception, immune defence mechanisms, cell migration, hormonal control or neurotransmission. Our research aims at studying GPCRs structure and function as well as the functional consequences of GPCRs homo- and hetero-oligomerization by using chemokine receptors as a model system. This family contains about 20 receptors expressed on a variety of cells including immune cells, endothelial cells and neurons. Chemokine receptors oligomerization is thought to play important roles in cells function by influencing receptors pharmacological properties, their coupling to signaling molecules like G-proteins or arrestins and their trafficking to and from the cell surface.
Tenured lecturer, Principal Investigator (Université Libre de Bruxelles)
Research topic:
G-protein coupled receptors (GPCRs) constitute one of the largest family of cell surface proteins in vertebrates and invertebrates. They play a wide range of physiological functions like sensory perception, immune defence mechanisms, cell migration, hormonal control or neurotransmission. Our research aims at studying GPCRs structure and function as well as the functional consequences of GPCRs homo- and hetero-oligomerization by using chemokine receptors as a model system. This family contains about 20 receptors expressed on a variety of cells including immune cells, endothelial cells and neurons. Chemokine receptors oligomerization is thought to play important roles in cells function by influencing receptors pharmacological properties, their coupling to signaling molecules like G-proteins or arrestins and their trafficking to and from the cell surface.
