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Jian-Min Chen
INSERM U613; EFS – Bretagne; IFR 148
46 rue Félix Le Dantec
29218 Brest, France.
Tel: +33-2-98018102
Fax: +33-2-98430555
Jian-Min.Chen@univ-brest.fr
Research Interests

1. Genetic basis of chronic pancreatitis and cystic fibrosis
2. Mutational and pathological mechanisms underlying human mutations

Education and Diplomas

1980.8-1982.7
Hebei Xinji Middle School, China

1982.8-1987.7
The Forth Military Medical University, Xian, China (Bachelor of Medicine)

1987.8-1990.7
Academy of Military Medical Sciences, Beijing, China (Master of Medicine)

1990.8-1993.7
Academy of Military Medical Sciences, Beijing, China (M.D)

1998.9-2002.12
Université de Bretagne Occidentale, Brest, France (Ph.D)

2007.6
Université de Bretagne Occidentale, Brest, France [Habilitation à Diriger la Recherche (HDR); Habilitation to Supervise Research]


Employment

2008.1 -
Directeur de Recherche
Etablissement Français du Sang-Bretagne
Brest, France

2005.9 - 2006.8
2002.9 - 2004.8
Professor of Genetics
Faculty of Medicine
Université de Bretagne Occidentale
Brest, France

2000.4 - 2007.12
Medical research scientist
Etablissement Français du Sang-Bretagne
Brest, France

1998.4 - 2000.3
Guest medical research scientist
INSERM
Brest, France

1996.7 - 1998.3
Post-doc
Department of Immunology
Institute for Frontier Medical Sciences
Kyoto University
Kyoto, Japan

1993.8 - 1996.6
Assistant professor
Institute of Basic Medical Sciences
Academy of Military Medical Sciences
Beijing, China

Journal articles

2008
 
DOI   
PMID 
Jian-Min Chen, Emmanuelle Masson, Milan Macek, Odile Raguénès, Tereza Piskackova, Brigitte Fercot, Libor Fila, David N Cooper, Marie-Pierre Audrézet, Claude Férec (2008)  Detection of two Alu insertions in the CFTR gene.   J Cyst Fibros 7: 1. 37-43 Jan  
Abstract: BACKGROUND: LINE-1 (long interspersed element-1) or L1-mediated retrotransposition is a potent force in human genome evolution and an occasional cause of human genetic disease. Since the first report of two de novo L1 insertions in the F8 gene causing hemophilia A, more than 50 L1-mediated retrotranspositional events have been identified as causing human genetic disease. However, a significant bias has generally militated against the detection of these pathological events at autosomal loci. Based upon this and other observations, we s