Department of Neuroscience
Karolinska Institutet
Retzius väg 8
17177 Stockholm
Sweden
 | dasiel.borroto.escuela@ki.se |
The hypothesis of intramembrane receptor-receptor interactions was born and tested for the first time at Kjell Fuxe Lab-KI in 1980-1981. The early work on negative cooperativity and neuropeptide-monoamine receptor-receptor interactions in the CNS gave the first indications of the existence of oligomers (homomers and heteromers) of GPCR and the field began to expand from receptor monomers into receptor oligomers and higher order oligomers.
I have been primarily focused on understanding the molecular integration of signals in the brain via receptor-receptor interaction in the heteroreceptor complexes and its functional effects which is a current scientific issue of high relevance for brain function and integration. And whether alterations in specific heteroreceptor complexes and their receptor-receptor interactions are associated with and/or play a role in pathogenetic mechanisms contributing to brain disease development, inter alia Parkinson's disease, schizophrenia, addiction and depression.
I'm very excited by the tremendous potential of the field of heteroreceptor complexes and my small daily ambition is to be part of this novel exciting field in Neurosciences. Also to develop new methods to describe in a better way receptor-receptor interactions in the brain. I have a strong interest in setting up and improve the in situ proximity ligation assays for identification and study of heteroreceptor complexes in the brain. Furthermore, on novel adaptations of conventional BRET, FRET, TR-FRET, BiFC to made possible the study GPCR oligomerization dynamics in heterologous expression systems and neurons.
I have been primarily focused on understanding the molecular integration of signals in the brain via receptor-receptor interaction in the heteroreceptor complexes and its functional effects which is a current scientific issue of high relevance for brain function and integration. And whether alterations in specific heteroreceptor complexes and their receptor-receptor interactions are associated with and/or play a role in pathogenetic mechanisms contributing to brain disease development, inter alia Parkinson's disease, schizophrenia, addiction and depression.
I'm very excited by the tremendous potential of the field of heteroreceptor complexes and my small daily ambition is to be part of this novel exciting field in Neurosciences. Also to develop new methods to describe in a better way receptor-receptor interactions in the brain. I have a strong interest in setting up and improve the in situ proximity ligation assays for identification and study of heteroreceptor complexes in the brain. Furthermore, on novel adaptations of conventional BRET, FRET, TR-FRET, BiFC to made possible the study GPCR oligomerization dynamics in heterologous expression systems and neurons.
