http://publicationslist.org/data/Boran.Altincicek/atom.xml Boran Altincicekhttp://publicationslist.org/Boran.Altincicek$basepathfavicon.icoRecent additions to Boran Altincicek's PublicationsList.org pagehttp://publicationslist.org/publications.png2009-08-24T08:41:16Z http://publicationslist.org/Boran.Altincicek/refid32 2009-08-24T08:40:39Z

Abstract The immune system can be stimulated by microbial molecules as well as by endogenously derived danger/alarm signals of host origin. Using the lepidopteran model insect Galleria mellonella we have recently discovered that fragments of collagen IV resulting from hydrolysis by microbial metalloproteinases represent danger/alarm signals in insects. Here, we characterized immune-stimulatory pep...<br/><br/> Altincicek, Berisha, Mukherjee, Spengler, Römpp, Vilcinskas (2009) <i>Biol Chem</i> : <br/>

http://publicationslist.org/Boran.Altincicek/refid30 2009-03-19T22:22:31Z

Lucilia sericata maggots are used world-wide in biosurgery for the medical treatment of nonhealing wounds because they ingest necrotic tissues and significantly promote healing. To gain further insight into interdependencies between ecological adaptation and molecular evolution of innate immunity in Diptera, we used the suppression subtractive hybridization method to screen for genes that are diff...<br/><br/>B Altincicek, A Vilcinskas (2009) <i>Insect Mol Biol</i> <i></i> <i></i> 18: 1 119-125<br/>

http://publicationslist.org/Boran.Altincicek/refid31 2009-07-07T21:03:49Z

BACKGROUND: Matrix metalloproteinases (MMPs) are evolutionarily conserved and multifunctional effector molecules in development and homeostasis. In spite of previous, intensive investigation in vitro and in cell culture, their pleiotrophic functions in vivo are still not well understood. METHODOLOGY/PRINCIPAL FINDINGS: We show that the genetically amenable beetle Tribolium castaneum represents a f...<br/><br/>Eileen Knorr, Henrike Schmidtberg, Andreas Vilcinskas, Boran Altincicek (2009) <i>PLoS One</i> <i></i> <i></i> 4: 3 <br/>

http://publicationslist.org/Boran.Altincicek/refid5 2008-11-02T13:05:38Z

Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory recepto...<br/><br/>Stephen Richards, Richard A Gibbs, George M Weinstock, Susan J Brown, Robin Denell, Richard W Beeman, Richard Gibbs, Gregor Bucher, Markus Friedrich, Cornelis J P Grimmelikhuijzen, Martin Klingler, Marce Lorenzen, Siegfried Roth, Reinhard Schröder, Diethard Tautz, Evgeny M Zdobnov, Donna Muzny, Tony Attaway, Stephanie Bell, Christian J Buhay, Mimi N Chandrabose, Dean Chavez, Kerstin P Clerk-Blankenburg, Andrew Cree, Marvin Dao, Clay Davis, Joseph Chacko, Huyen Dinh, Shannon Dugan-Rocha, Gerald Fowler, Toni T Garner, Jeffrey Garnes, Andreas Gnirke, Alica Hawes, Judith Hernandez, Sandra Hines, Michael Holder, Jennifer Hume, Shalini N Jhangiani, Vandita Joshi, Ziad Mohid Khan, LaRonda Jackson, Christie Kovar, Andrea Kowis, Sandra Lee, Lora R Lewis, Jon Margolis, Margaret Morgan, Lynne V Nazareth, Ngoc Nguyen, Geoffrey Okwuonu, David Parker, San-Juana Ruiz, Jireh Santibanez, Joël Savard, Steven E Scherer, Brian Schneider, Erica Sodergren, Selina Vattahil, Donna Villasana, Courtney S White, Rita Wright, Yoonseong Park, Jeff Lord, Brenda Oppert, Susan Brown, Liangjiang Wang, George Weinstock, Yue Liu, Kim Worley, Christine G Elsik, Justin T Reese, Eran Elhaik, Giddy Landan, Dan Graur, Peter Arensburger, Peter Atkinson, Jim Beidler, Jeffery P Demuth, Douglas W Drury, Yu-Zhou Du, Haruhiko Fujiwara, Vincenza Maselli, Mizuko Osanai, Hugh M Robertson, Zhijian Tu, Jian-jun Wang, Suzhi Wang, Henry Song, Lan Zhang, Doreen Werner, Mario Stanke, Burkhard Morgenstern, Victor Solovyev, Peter Kosarev, Garth Brown, Hsiu-Chuan Chen, Olga Ermolaeva, Wratko Hlavina, Yuri Kapustin, Boris Kiryutin, Paul Kitts, Donna Maglott, Kim Pruitt, Victor Sapojnikov, Alexandre Souvorov, Aaron J Mackey, Robert M Waterhouse, Stefan Wyder, Evgenia V Kriventseva, Tatsuhiko Kadowaki, Peer Bork, Manuel Aranda, Riyue Bao, Anke Beermann, Nicola Berns, Renata Bolognesi, François Bonneton, Daniel Bopp, Thomas Butts, Arnaud Chaumot, Robin E Denell, David E K Ferrier, Cassondra M Gordon, Marek Jindra, Que Lan, H Michael G Lattorff, Vincent Laudet, Cornelia von Levetsow, Zhenyi Liu, Rebekka Lutz, Jeremy A Lynch, Rodrigo Nunes da Fonseca, Nico Posnien, Rolf Reuter, Johannes B Schinko, Christian Schmitt, Michael Schoppmeier, Teresa D Shippy, Franck Simonnet, Henrique Marques-Souza, Yoshinori Tomoyasu, Jochen Trauner, Maurijn Van der Zee, Michel Vervoort, Nadine Wittkopp, Ernst A Wimmer, Xiaoyun Yang, Andrew K Jones, David B Sattelle, Paul R Ebert, David Nelson, Jeffrey G Scott, Subbaratnam Muthukrishnan, Karl J Kramer, Yasuyuki Arakane, Qingsong Zhu, David Hogenkamp, Radhika Dixit, Haobo Jiang, Zhen Zou, Jeremy Marshall, Elena Elpidina, Konstantin Vinokurov, Cris Oppert, Jay Evans, Zhiqiang Lu, Picheng Zhao, Niranji Sumathipala, Boran Altincicek, Andreas Vilcinskas, Michael Williams, Dan Hultmark, Charles Hetru, Frank Hauser, Giuseppe Cazzamali, Michael Williamson, Bin Li, Yoshiaki Tanaka, Reinhard Predel, Susanne Neupert, Joachim Schachtner, Peter Verleyen, Florian Raible, Kimberly K O Walden, Sergio Angeli, Sylvain Forêt, Stefan Schuetz, Ryszard Maleszka, Sherry C Miller, Daniela Grossmann (2008) <i>Nature</i> <i></i> <i></i> 452: 7190 949-955<br/>

http://publicationslist.org/Boran.Altincicek/refid8 2008-11-02T13:05:38Z

Matrix metalloproteinases (MMPs) are key enzymes in mammalian tissue remodeling and inflammation. Recently, we postulated that an endogenous MMP expressed in the lepidopteran model Galleria mellonella during metamorphosis causes degradation of collagen-IV, which in turn results in activation of innate immunity. Here, we report that degradation of collagen-IV by hemocytes is enhanced upon injection...<br/><br/>Boran Altincicek, Andreas Vilcinskas (2008) <i>Dev Comp Immunol</i> <i></i> <i></i> 32: 4 400-409<br/>

http://publicationslist.org/Boran.Altincicek/refid4 2009-07-07T21:03:49Z

ABSTRACT: BACKGROUND: The planarian Schmidtea mediterranea and the cnidarian Hydra vulgaris have emerged as valuable model organisms in regeneration and stem cell research because of their prominent ability to regenerate a complete organism from any small body fragment. Under natural conditions wounding may result from predator attacks. These injuries open their innermost to a wide array of microb...<br/><br/>Boran Altincicek, Andreas Vilcinskas (2008) <i>Front Zool</i> <i></i> <i></i> 5: <br/>

http://publicationslist.org/Boran.Altincicek/refid6 2008-11-02T13:05:38Z

The red flour beetle, Tribolium castaneum, is an established genetically tractable model insect for evolutionary and developmental studies. Therefore, it may also represent a valuable model for comparative analysis of insect immunity. Here, we used the suppression subtractive hybridization method to identify Tribolium genes that are transcriptionally induced in response to injection of crude lipop...<br/><br/>Boran Altincicek, Eileen Knorr, Andreas Vilcinskas (2008) <i>Dev Comp Immunol</i> <i></i> <i></i> 32: 5 585-595<br/>

http://publicationslist.org/Boran.Altincicek/refid2 2008-11-02T13:05:38Z

Extracellular nucleic acids play important roles in human immunity and hemostasis by inducing IFN production, entrapping pathogens in neutrophil extracellular traps, and providing procoagulant cofactor templates for induced contact activation during mammalian blood clotting. In this study, we investigated the functions of extracellular RNA and DNA in innate immunity and hemolymph coagulation in in...<br/><br/>Boran Altincicek, Sabine Stötzel, Malgorzata Wygrecka, Klaus T Preissner, Andreas Vilcinskas (2008) <i>J Immunol</i> <i></i> <i></i> 181: 4 2705-2712<br/>

http://publicationslist.org/Boran.Altincicek/refid3 2009-01-24T09:55:31Z

Onychophora are the next relatives of Arthropoda and, hence, represent an important taxon to unravel relationships among Insecta, Crustacea, Arachnida, and Myriapoda. Here, we screened for immune inducible genes from the onychophoran Epiperipatus biolleyi (Peripatidae) by injecting crude bacterial LPS and applying the suppression subtractive hybridization technique. Our analysis of 288 cDNAs resul...<br/><br/>Boran Altincicek, Andreas Vilcinskas (2008) <i>Dev Comp Immunol</i> <i></i> <i></i> 32: 12 1416-1421<br/>

http://publicationslist.org/Boran.Altincicek/refid1 2009-03-19T22:22:31Z

Most insects mount a potent antimicrobial defence upon contact with microbes or microbe-associated pattern molecules. Using a combined set of methods for analysis of insect innate immunity, we report here that piercing of the pea aphid Acyrthosiphon pisum with a bacteria-contaminated needle elicits lysozyme-like activity in the haemolymph but no detectable activities against live bacteria. Confirm...<br/><br/>B Altincicek, J Gross, A Vilcinskas (2008) <i>Insect Mol Biol</i> <i></i> <i></i> 17: 6 711-716<br/>

http://publicationslist.org/Boran.Altincicek/refid11 2008-11-02T13:05:38Z

The insect metalloproteinase inhibitor (IMPI) from the greater wax moth, Galleria mellonella, represents the first and to date only specific inhibitor of microbial metalloproteinases reported from animals. Here, we report on the characterization including carbohydrate analysis of two recombinant constructs encoded by impi cDNA either upstream or downstream of the furin cleavage site identified. rI...<br/><br/>Marianne Wedde, Christoph Weise, Rolf Nuck, Boran Altincicek, Andreas Vilcinskas (2007) <i>Biol Chem</i> <i></i> <i></i> 388: 1 119-127<br/>

http://publicationslist.org/Boran.Altincicek/refid12 2008-11-02T13:05:38Z

Thermolysin-like metalloproteinases such as aureolysin, pseudolysin, and bacillolysin represent virulence factors of diverse bacterial pathogens. Recently, we discovered that injection of thermolysin into larvae of the greater wax moth, Galleria mellonella, mediated strong immune responses. Thermolysin-mediated proteolysis of hemolymph proteins yielded a variety of small-sized (<3 kDa) protein fra...<br/><br/>Boran Altincicek, Monica Linder, Dietmar Linder, Klaus T Preissner, Andreas Vilcinskas (2007) <i>Infect Immun</i> <i></i> <i></i> 75: 1 175-183<br/>

http://publicationslist.org/Boran.Altincicek/refid10 2008-11-02T13:05:38Z

In this study, we report the analysis of the immune-related transcriptome from an apterygote insect, the firebrat Thermobia domestica (Zygentoma, Lepismatidae), which currently emerges as a suitable model insect for evolutionary and developmental studies. The suppression subtractive hybridization method was used for targeted screening of genes that are up-regulated in response to injected bacteria...<br/><br/>Boran Altincicek, Andreas Vilcinskas (2007) <i>Insect Biochem Mol Biol</i> <i></i> <i></i> 37: 7 726-731<br/>

http://publicationslist.org/Boran.Altincicek/refid9 2008-11-02T13:05:38Z

BACKGROUND: The marine annelid Platynereis dumerilii (Polychaeta, Nereididae) has been recognized as a slow-evolving lophotrochozoan that attracts increasing attention as a valuable model for evolutionary and developmental research. Here, we analyzed its immune-related transcriptome. For targeted identification of immune-induced genes we injected bacterial lipopolysaccharide, a commonly used elici...<br/><br/>Boran Altincicek, Andreas Vilcinskas (2007) <i>Front Zool</i> <i></i> <i></i> 4: <br/>

http://publicationslist.org/Boran.Altincicek/refid7 2008-11-02T13:05:38Z

BACKGROUND: The saprophagous and coprophagous maggots of the drone fly Eristalis tenax (Insecta, Diptera) have evolved the unique ability to survive in aquatic habitats with extreme microbial stress such as drains, sewage pools, and farmyard liquid manure storage pits. Therefore, they represent suitable models for the investigation of trade-offs between the benefits resulting from colonization of ...<br/><br/>Boran Altincicek, Andreas Vilcinskas (2007) <i>BMC Genomics</i> <i></i> <i></i> 8: <br/>

http://publicationslist.org/Boran.Altincicek/refid15 2008-11-02T13:05:38Z

FSAP (Factor VII-activating protease) is a novel plasma-derived serine protease that regulates haemostasis as well as vascular cell proliferation. FSAP undergoes autoactivation in the presence of polyanionic macromolecules such as heparin and RNA. Competition experiments suggest that RNA and heparin bind to the same or overlapping interaction sites. A proteolysis approach, where FSAP was hydrolyse...<br/><br/>Boran Altincicek, Aya Shibamiya, Heidi Trusheim, Eleni Tzima, Michael Niepmann, Dietmar Linder, Klaus T Preissner, Sandip M Kanse (2006) <i>Biochem J</i> <i></i> <i></i> 394: Pt 3 687-692<br/>

http://publicationslist.org/Boran.Altincicek/refid14 2008-11-02T13:05:38Z

A novel link between development and immunity in insects is introduced. Transiently enhanced expression of lysozyme, gallerimycin and the insect metalloproteinase inhibitor was discovered at the onset of metamorphosis of the greater wax moth, Galleria mellonella. Relative quantification of mRNAs encoding for these antimicrobial peptides using real-time PCR documents their induced expression during...<br/><br/>Boran Altincicek, Andreas Vilcinskas (2006) <i>Dev Comp Immunol</i> <i></i> <i></i> 30: 12 1108-1118<br/>

http://publicationslist.org/Boran.Altincicek/refid13 2008-11-02T13:05:38Z

A cDNA encoding gallerimycin, a novel antifungal peptide from the greater wax moth Galleria mellonella, was isolated from a cDNA library of genes expressed during innate immune response in the caterpillars. Upon ectopic expression of gallerimycin in tobacco, using Agrobacterium tumefaciens as a vector, gallerimycin conferred resistance to the fungal pathogens Erysiphe cichoracearum and Sclerotinia...<br/><br/>Gregor Langen, Jafargholi Imani, Boran Altincicek, Gernot Kieseritzky, Karl-Heinz Kogel, Andreas Vilcinskas (2006) <i>Biol Chem</i> <i></i> <i></i> 387: 5 549-557<br/>

http://publicationslist.org/Boran.Altincicek/refid17 2008-11-02T13:05:38Z

The gcpE gene product controls one of the terminal steps of isoprenoid biosynthesis via the mevalonate independent 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. This pathway is utilized by a variety of eubacteria, the plastids of algae and higher plants, and the plastid-like organelle of malaria parasites. Recombinant GcpE protein from the hyperthermophilic bacterium Thermus thermophilus was ...<br/><br/>Ann-Kristin Kollas, Evert C Duin, Matthias Eberl, Boran Altincicek, Martin Hintz, Armin Reichenberg, Dajana Henschker, Anke Henne, Irina Steinbrecher, Dmitry N Ostrovsky, Reiner Hedderich, Ewald Beck, Hassan Jomaa, Jochen Wiesner (2002) <i>FEBS Lett</i> <i></i> <i></i> 532: 3 432-436<br/>

http://publicationslist.org/Boran.Altincicek/refid16 2008-11-02T13:05:38Z

Recombinant LytB protein from the thermophilic eubacterium Aquifex aeolicus produced in Escherichia coli was purified to apparent homogeneity. The purified LytB protein catalyzed the reduction of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) in a defined in vitro system. The reaction products were identified as isopentenyl diphosphate and dimethylallyl diphosphate. A spectrophotometric ass...<br/><br/>Boran Altincicek, Evert C Duin, Armin Reichenberg, Reiner Hedderich, Ann-Kristin Kollas, Martin Hintz, Stefanie Wagner, Jochen Wiesner, Ewald Beck, Hassan Jomaa (2002) <i>FEBS Lett</i> <i></i> <i></i> 532: 3 437-440<br/>

http://publicationslist.org/Boran.Altincicek/refid18 2008-11-02T13:05:38Z

Activation of human Vgamma9/Vdelta2 T cells by many pathogens depends on the presence of small phosphorylated non-peptide compounds derived from the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway of isoprenoid biosynthesis. We here demonstrate that in Escherichia coli mutants deficient in lytB, an essential gene of the MEP pathway, a potent Vgamma9/Vdelta2 T-cell activator accumulates by a fact...<br/><br/>Matthias Eberl, Boran Altincicek, Ann-Kristin Kollas, Silke Sanderbrand, Ute Bahr, Armin Reichenberg, Ewald Beck, Donald Foster, Jochen Wiesner, Martin Hintz, Hassan Jomaa (2002) <i>Immunology</i> <i></i> <i></i> 106: 2 200-211<br/>

http://publicationslist.org/Boran.Altincicek/refid22 2008-11-02T13:05:38Z

The fosmidomycin derivative FR900098 represents an inhibitor of the 1-deoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase with potent antimalarial activity. Prodrugs of FR900098 with increased activity after oral administration were obtained by chemical modification of the phosphonate moiety to yield phosphodiaryl esters. One diaryl ester prodrug demonstrated efficacy in mice infected with the ro...<br/><br/>A Reichenberg, J Wiesner, C Weidemeyer, E Dreiseidler, S Sanderbrand, B Altincicek, E Beck, M Schlitzer, H Jomaa (2001) <i>Bioorg Med Chem Lett</i> <i></i> <i></i> 11: 6 833-835<br/>

http://publicationslist.org/Boran.Altincicek/refid24 2008-11-02T13:05:38Z

Activation of V gamma 9/V delta 2 T cells by small nonprotein Ags is frequently observed after infection with various viruses, bacteria, and eukaryotic parasites. We suggested earlier that compounds synthesized by the 2-C:-methyl-D-erythritol 4-phosphate (MEP) pathway of isopentenyl pyrophosphate synthesis are responsible for the V gamma 9/V delta 2 T cell reactivity of many pathogens. Using genet...<br/><br/>B Altincicek, J Moll, N Campos, G Foerster, E Beck, J F Hoeffler, C Grosdemange-Billiard, M Rodríguez-Concepción, M Rohmer, A Boronat, M Eberl, H Jomaa (2001) <i>J Immunol</i> <i></i> <i></i> 166: 6 3655-3658<br/>

http://publicationslist.org/Boran.Altincicek/refid23 2008-11-02T13:05:38Z

In a variety of organisms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. In this work, we demonstrate that the gcpE gene of Escherichia coli is invol...<br/><br/>B Altincicek, A K Kollas, S Sanderbrand, J Wiesner, M Hintz, E Beck, H Jomaa (2001) <i>J Bacteriol</i> <i></i> <i></i> 183: 8 2411-2416<br/>

http://publicationslist.org/Boran.Altincicek/refid21 2008-11-02T13:05:38Z

J Wiesner, S Sanderbrand, B Altincicek, E Beck, H Jomaa (2001) <i>Trends Parasitol</i> <i></i> <i></i> 17: 1 7-8<br/>

http://publicationslist.org/Boran.Altincicek/refid19 2008-11-02T13:05:38Z

The gcpE and lytB gene products control the terminal steps of isoprenoid biosynthesis via the 2-C-methyl-D-erythritol 4-phosphate pathway in Escherichia coli. In lytB-deficient mutants, a highly immunogenic compound accumulates significantly, compared to wild-type E. coli, but is apparently absent in gcpE-deficient mutants. Here, this compound was purified from E. coli DeltalytB mutants by prepara...<br/><br/>M Hintz, A Reichenberg, B Altincicek, U Bahr, R M Gschwind, A K Kollas, E Beck, J Wiesner, M Eberl, H Jomaa (2001) <i>FEBS Lett</i> <i></i> <i></i> 509: 2 317-322<br/>

http://publicationslist.org/Boran.Altincicek/refid20 2008-11-02T13:05:38Z

The mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis is essential in many eubacteria, plants, and the malaria parasite. Using genetically engineered Escherichia coli cells able to utilize exogenously provided mevalonate for isoprenoid biosynthesis by the mevalonate pathway we demonstrate that the lytB gene is involved in the trunk line of the MEP...<br/><br/>B Altincicek, A Kollas, M Eberl, J Wiesner, S Sanderbrand, M Hintz, E Beck, H Jomaa (2001) <i>FEBS Lett</i> <i></i> <i></i> 499: 1-2 37-40<br/>

http://publicationslist.org/Boran.Altincicek/refid27 2008-11-02T13:05:38Z

DAX-1 is an unusual member of the nuclear hormone receptor (NHR) superfamily. Lack of DAX-1-mediated silencing leads to adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Gene silencing through NHRs such as the thyroid hormone receptor (TR) is mediated by corepressors. We have previously characterized a novel corepressor, termed Alien, which interacts with TR and the ecdysone receptor...<br/><br/>B Altincicek, S P Tenbaum, U Dressel, D Thormeyer, R Renkawitz, A Baniahmad (2000) <i>J Biol Chem</i> <i></i> <i></i> 275: 11 7662-7667<br/>

http://publicationslist.org/Boran.Altincicek/refid25 2008-11-02T13:05:38Z

J Wiesner, M Hintz, B Altincicek, S Sanderbrand, C Weidemeyer, E Beck, H Jomaa (2000) <i>Exp Parasitol</i> <i></i> <i></i> 96: 3 182-186<br/>

http://publicationslist.org/Boran.Altincicek/refid26 2008-11-02T13:05:38Z

Two Pseudomonas aeruginosa genes encoding the enzymes 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase, both involved in the mevalonate-independent biosynthesis of isoprenoids, have been expressed as recombinant enzymes in Escherichia coli. The purified P. aeruginosa DXP reductoisomerase was inhibited by submicromolar concentrations of the antibiotics fosmidomycin and FR-9000...<br/><br/>B Altincicek, M Hintz, S Sanderbrand, J Wiesner, E Beck, H Jomaa (2000) <i>FEMS Microbiol Lett</i> <i></i> <i></i> 190: 2 329-333<br/>

http://publicationslist.org/Boran.Altincicek/refid29 2008-11-02T13:05:38Z

Some members of nuclear hormone receptors, such as the thyroid hormone receptor (TR), silence gene expression in the absence of the hormone. Corepressors, which bind to the receptor's silencing domain, are involved in this repression. Hormone binding leads to dissociation of corepressors and binding of coactivators, which in turn mediate gene activation. Here, we describe the characteristics of Al...<br/><br/>U Dressel, D Thormeyer, B Altincicek, A Paululat, M Eggert, S Schneider, S P Tenbaum, R Renkawitz, A Baniahmad (1999) <i>Mol Cell Biol</i> <i></i> <i></i> 19: 5 3383-3394<br/>

http://publicationslist.org/Boran.Altincicek/refid28 2008-11-02T13:05:38Z

A mevalonate-independent pathway of isoprenoid biosynthesis present in Plasmodium falciparum was shown to represent an effective target for chemotherapy of malaria. This pathway includes 1-deoxy-D-xylulose 5-phosphate (DOXP) as a key metabolite. The presence of two genes encoding the enzymes DOXP synthase and DOXP reductoisomerase suggests that isoprenoid biosynthesis in P. falciparum depends on t...<br/><br/>H Jomaa, J Wiesner, S Sanderbrand, B Altincicek, C Weidemeyer, M Hintz, I Türbachova, M Eberl, J Zeidler, H K Lichtenthaler, D Soldati, E Beck (1999) <i>Science</i> <i></i> <i></i> 285: 5433 1573-1576<br/>