http://publicationslist.org/data/George.CT.Jiang/atom.xml George Jianghttp://publicationslist.org/George.CT.Jiang$basepathfavicon.icoRecent additions to George Jiang's PublicationsList.org pagehttp://publicationslist.org/publications.png2010-08-16T14:18:54Z http://publicationslist.org/George.CT.Jiang/refid17 2010-03-01T14:31:06Z

Depleted uranium (DU) is the major by-product of the uranium enrichment process for its more radioactive isotopes, retaining approximately 60% of its natural radioactivity. Given its properties as a pyrophoric and dense metal, it has been extensively used in armor and ammunitions. Questions have been raised regarding the possible neurotoxic effects of DU in humans based on follow-up studies in Gul...<br/><br/>Michael Aschner, George C-T Jiang (2009) <i>Journal of Toxicology and Environmental Health, Part B</i> 12: 7 525-539<br/>

http://publicationslist.org/George.CT.Jiang/refid16 2010-08-16T14:09:36Z

Depleted Uranium (DU) is a dense and heavy metal used in armor, ammunition, radiation shielding and counterbalances. The military usage has led to growing public concern regarding the health effects of DU. In this study, we used the nematode, Caenorhabditis elegans (C. elegans), to evaluate the toxicity of DU and its effects in knockout strains of metallothioneins, which are small, thiol-rich prot...<br/><br/>George C-T Jiang, Sam Hughes, Stephen R Stürzenbaum, Lars Evje, Tore Syversen, Michael Aschner (2009) <i>Toxicol Sci</i> : <br/>

http://publicationslist.org/George.CT.Jiang/refid13 2009-06-24T15:30:58Z

George C-T Jiang, Michael Aschner (2009) <i>Handbook of the Toxicology of Chemical Warfare Agents.</i> <br/>

http://publicationslist.org/George.CT.Jiang/refid15 2010-08-16T14:12:24Z

Due to its unique chemical properties, chrysotile asbestos was historically incorporated into a wide variety of products, including the outer covering, or “flux” of certain classifications of general arc mild steel welding electrodes. The purpose of this analysis is to review the historical engineering, toxicology, regulatory, and epidemiology information relevant to asbestos in mild steel wel...<br/><br/>Jennifer S Pierce, George C-T Jiang, Brent L Finley (2008) <i>Toxicological and Environmental Chemistry</i> 90: 5 917-956<br/>

http://publicationslist.org/George.CT.Jiang/refid1 2009-06-05T01:33:25Z

Although automotive friction products (brakes and manual clutches) historically contained chrysotile asbestos, industrial hygiene surveys and epidemiologic studies of auto mechanics have consistently shown that these workers are not at an increased risk of developing asbestos-related diseases. Airborne asbestos levels during brake repair and brake parts handling have been well-characterized, but t...<br/><br/>George C T Jiang, Amy K Madl, Kelsey J Ingmundson, Dana M Murbach, Kurt A Fehling, Dennis J Paustenbach, Brent L Finley (2008) <i>Regul Toxicol Pharmacol</i> 51: 1 87-97<br/>

http://publicationslist.org/George.CT.Jiang/refid8 2009-06-05T01:34:25Z

The focus of this study was to characterize the impact of gestational exposure to benzo(a)pyrene [B(a)P] on modulation of glutamate receptor subunit expression that is critical for the maintenance of synaptic plasticity mechanisms during hippocampal or cortical development in offspring. Previous studies have demonstrated that hippocampal and/or cortical synaptic plasticity (as measured by long-ter...<br/><br/>La'Nissa A Brown, Habibeh Khousbouei, J Shawn Goodwin, Charletha V Irvin-Wilson, Aramandla Ramesh, Liu Sheng, Monique M McCallister, George C T Jiang, Michael Aschner, Darryl B Hood (2007) <i>Neurotoxicology</i> 28: 5 965-978<br/>

http://publicationslist.org/George.CT.Jiang/refid9 2009-06-05T01:37:02Z

Depleted uranium (DU) is an extremely dense metal that is used in radiation shielding, counterbalances, armor, and ammunition. In light of the public concerns about exposure to DU and its potential role in Gulf War Syndrome (GWS), this study evaluated the neurotoxic potential of DU using focused studies on primary rat cortical neurons and the nematode Caenorhabditis elegans. We examined cell viabi...<br/><br/>George C-T Jiang, Kristen Tidwell, Beth Ann McLaughlin, Jiyang Cai, Ramesh C Gupta, Dejan Milatovic, Richard Nass, Michael Aschner (2007) <i>Toxicol Sci</i> 99: 2 553-565<br/>

http://publicationslist.org/George.CT.Jiang/refid11 2009-06-24T15:28:16Z

Enzymes are the metabolic catalysts that affect a multitude of physiological processes and responses. Tight control of enzyme activity is therefore essential in maintaining the steady state of all organisms.<br/><br/>Shorena Nadaraia, George J Yohrling, George C-T Jiang, John M Flanagan, Kent E Vrana (2007) <i>Encyclopedia of Life Sciences.</i> <br/>

http://publicationslist.org/George.CT.Jiang/refid7 2009-06-05T01:51:47Z

Depleted uranium (DU) is a byproduct of the enrichment process of uranium for its more radioactive isotopes to be used in nuclear energy. Because DU is pyrophoric and a dense metal with unique features when combined in alloys, it is used by the military in armor and ammunitions. There has been significant public concern regarding the use of DU by such armed forces, and it has been hypothesized to ...<br/><br/>George C-T Jiang, Michael Aschner (2006) <i>Biol Trace Elem Res</i> 110: 1 1-17<br/>

http://publicationslist.org/George.CT.Jiang/refid6 2009-06-05T01:42:59Z

Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disorder that is pathologically characterized by a striatal-specific degeneration. Aberrant dopamine neurotransmission has been proposed as a mechanism underlying the movement disorder of HD. We report that the enzymatic activity of tyrosine hydroxylase (TH), the rate-limiting enzyme for dopamine biosynthesis, is decr...<br/><br/>George J Yohrling, George C-T Jiang, Molly M DeJohn, David W Miller, Anne B Young, Kent E Vrana, Jang-Ho J Cha (2003) <i>Brain Res Mol Brain Res</i> 119: 1 28-36<br/>

http://publicationslist.org/George.CT.Jiang/refid5 2009-06-05T01:45:23Z

The pathogenic mechanisms of the mutant huntingtin protein that cause Huntington's disease (HD) are unknown. Previous studies have reported significant decreases in the levels of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the brains of the R6/2 transgenic mouse model of HD. In an attempt to elucidate the cause of these neurochemical perturbations in HD, the protein ...<br/><br/>George J Yohrling, George C-T Jiang, Molly M DeJohn, Daniel J Robertson, Kent E Vrana, Jang-Ho J Cha (2002) <i>J Neurochem</i> 82: 6 1416-1423<br/>

http://publicationslist.org/George.CT.Jiang/refid4 2009-06-05T01:04:34Z

Tyrosine hydroxylase (TH) is modified by nitration after exposure of mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydrophenylpyridine. The temporal association of tyrosine nitration with inactivation of TH activity in vitro suggests that this covalent post-translational modification is responsible for the in vivo loss of TH function (Ara, J., Przedborski, S., Naini, A. B., Jackson-Lewis, V., Trifiletti,...<br/><br/>Beatrice Blanchard-Fillion, Jose M Souza, Thomas Friel, George C-T Jiang, Kent E Vrana, Victor Sharov, Lorenzo Barrón, Christian Schöneich, Celia Quijano, Beatriz Alvarez, Rafael Radi, Serge Przedborski, Gayani S Fernando, Joel Horwitz, Harry Ischiropoulos (2001) <i>J Biol Chem</i> 276: 49 46017-46023<br/>

http://publicationslist.org/George.CT.Jiang/refid2 2010-08-16T14:16:54Z

Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin (5-HT) belongs to the aromatic amino acid hydroxylase superfamily, which includes phenylalanine hydroxylase (PAH) and tyrosine hydroxylase (TH). The crystal structures for both PAH and TH have been reported, but a crystallographic model of TPH remains elusive. For this reason, we have utili...<br/><br/>George J Yohrling, George C-T Jiang, Susan M Mockus, Kent E Vrana (2000) <i>J Neurosci Res</i> 61: 3 313-320<br/>

http://publicationslist.org/George.CT.Jiang/refid10 2009-06-05T01:28:35Z

Phenylketonuria is an autosomal recessive metabolic disorder resulting in increased phenylalanine concentrations. This treatable condition is a leading cause of mental retardation.<br/><br/>George C-T Jiang, George J Yohrling, Kent E Vrana (2000) <i>Encyclopedia of Life Sciences.</i> <br/>

http://publicationslist.org/George.CT.Jiang/refid3 2009-06-05T01:11:01Z

Tryptophan hydroxylase (TPH) is the initial and rate-limiting enzyme in the biosynthesis of serotonin. The inherent instability of TPH has prevented a crystallographic structure from being resolved. For this reason, multiple sequence alignment-based molecular modeling was utilized to generate a full-length model of human TPH. Previously determined crystal coordinates of two highly homologous prote...<br/><br/>George C-T Jiang, George J Yohrling, Jeffrey D Schmitt, Kent E Vrana (2000) <i>J Mol Biol</i> 302: 4 1005-1017<br/>

http://publicationslist.org/George.CT.Jiang/refid12 2009-06-05T01:29:01Z

Enzymes are the metabolic catalysts that affect a multitude of physiological processes and responses. Tight control of enzyme activity is therefore essential in maintaining the steady state of all organisms.<br/><br/>George J Yohrling, George C-T Jiang, Kent E Vrana (2000) <i>Encyclopedia of Life Sciences.</i> <br/>

http://publicationslist.org/George.CT.Jiang/refid14 2009-06-05T02:15:53Z

Francis X Cunningham, George C-T Jiang, Elisabeth Gantt (1997) <i>Plant Physiology</i> 114: 3 926 Suppl. S<br/>