http://publicationslist.org/data/Lachenmeier/atom.xml Dirk Lachenmeierhttp://publicationslist.org/Lachenmeier$basepathfavicon.icoRecent additions to Dirk Lachenmeier's PublicationsList.org pagehttp://publicationslist.org/publications.png2012-01-31T13:05:35Z http://publicationslist.org/Lachenmeier/refid122 2012-01-31T13:02:22Z

The aim of this work was to analyse the furan concentrations in coffee products targeted to adolescents and to estimate the health risk for those consumers by using the consumption data of the Dortmund Nutritional and Anthropometric Longitudinally Designed Study (DONALD). Three different kinds of coffee beverages were analysed: 'coffee ready to drink' (i.e. industrially manufactured and packaged p...<br/><br/>J Waizenegger, G Winkler, T Kuballa, W Ruge, M Kersting, U Alexy, D W Lachenmeier (2012) <i>Food Addit Contam Part A Chem Anal Control Expo Risk Assess</i> <i></i> <i></i> 29: 1 19-28<br/>

http://publicationslist.org/Lachenmeier/refid119 2012-01-31T13:02:22Z

Dirk W Lachenmeier, Yulia B Monakhova, Andriy V Samokhvalov, Jürgen Rehm (2012) <i>Clin Toxicol (Phila)</i> <i></i> <i></i> : <br/>

http://publicationslist.org/Lachenmeier/refid124 2012-01-31T13:02:22Z

The use of thujone, a monoterpene ketone often present in sage (Salvia officinalis L.) or wormwood (Artemisia absinthium L.), for the treatment of diabetes mellitus was recently suggested in a study published in this journal. Evidence was based on the findings obtained in a diabetic rat model. After oral treatment with thujone (5 mg/kg bodyweight (bw)/day for 28 days), the cholesterol and trig...<br/><br/>Dirk W Lachenmeier, Stephan G Walch (2011) <i>Nat Prod Res</i> <i></i> <i></i> 25: 20 1890-1892<br/>

http://publicationslist.org/Lachenmeier/refid125 2012-01-31T13:02:22Z

Dirk W Lachenmeier, Ben Taylor, Jürgen Rehm (2011) <i>Pancreas</i> <i></i> <i></i> 40: 7 1143-4; author reply 1144-5<br/>

http://publicationslist.org/Lachenmeier/refid126 2012-01-31T13:02:22Z

Sage tea, the aqueous infusion of dried sage leaves (Salvia officinalis L.), is used as a form of food as well as a form of traditional herbal medicine. Several in vivo and in vitro studies point to sage polyphenols as active principles that may inhibit lipid peroxidation and improve antioxidant defences. This study describes an UHPLC methodology with MS/MS and UV detection, which allows the separ...<br/><br/>Benno F Zimmermann, Stephan G Walch, Laura Ngaba Tinzoh, Wolf Stühlinger, Dirk W Lachenmeier (2011) <i>J Chromatogr B Analyt Technol Biomed Life Sci</i> <i></i> <i></i> 879: 24 2459-2464<br/>

http://publicationslist.org/Lachenmeier/refid123 2012-01-31T13:02:22Z

The 400 MHz (1)H NMR analysis of alcoholic beverages using standard pulse programs lacks the necessary sensitivity to detect minor constituents such as methanol, acetaldehyde or ethyl acetate. This study investigates the application of a shaped pulse sequence during the relaxation delay to suppress the eight (1)H NMR frequencies of water and ethanol (the OH singlet of both water and ethanol, as we...<br/><br/>Yulia B Monakhova, Hartmut Schäfer, Eberhard Humpfer, Manfred Spraul, Thomas Kuballa, Dirk W Lachenmeier (2011) <i>Magn Reson Chem</i> <i></i> <i></i> 49: 11 734-739<br/>

http://publicationslist.org/Lachenmeier/refid137 2012-01-31T13:02:54Z

Dirk W Lachenmeier, Fotis Kanteres, Jürgen Rehm (2011) <i>J Agric Food Chem</i> <i></i> <i></i> 59: 1 464-5; author reply 466<br/>

http://publicationslist.org/Lachenmeier/refid138 2012-01-31T13:05:02Z

Yann Grosse, Robert Baan, Béatrice Secretan-Lauby, Fatiha El Ghissassi, Véronique Bouvard, Lamia Benbrahim-Tallaa, Neela Guha, Farhad Islami, Laurent Galichet, Kurt Straif (2011) <i>Lancet Oncol</i> <i></i> <i></i> 12: 4 328-329<br/>

http://publicationslist.org/Lachenmeier/refid111 2012-01-31T13:02:54Z

A novel approach to derive a threshold dose with respect to alcohol-related harm, the benchmark dose (BMD) methodology, is introduced to provide a basis for evidence-based drinking guidelines. This study is the first to calculate a BMD for alcohol exposure using epidemiological cohort data. With this BMD we will be able to calculate the margin of exposure (MOE) for alcohol consumption, which can b...<br/><br/>Dirk W Lachenmeier, Fotis Kanteres, Jürgen Rehm (2011) <i>Int J Epidemiol</i> <i></i> <i></i> 40: 1 210-218<br/>

http://publicationslist.org/Lachenmeier/refid120 2012-01-31T13:02:22Z

Sage (Salvia officinalis L.) is used as an herbal medicinal product, with the most typical form of application as infusion with boiling water (sage tea). The well-established traditional uses include symptomatic treatment of mild dyspeptic complaints, the treatment of inflammations in the mouth and the throat, and relief of excessive sweating and relief of minor skin inflammations. In this study, ...<br/><br/>Stephan G Walch, Laura Ngaba Tinzoh, Benno F Zimmermann, Wolf Stühlinger, Dirk W Lachenmeier (2011) <i>Front Pharmacol</i> <i></i> <i></i> 2: <br/>

http://publicationslist.org/Lachenmeier/refid127 2012-01-31T13:02:22Z

ABSTRACT:<br/><br/>Stephan G Walch, Thomas Kuballa, Wolf Stühlinger, Dirk W Lachenmeier (2011) <i>Chem Cent J</i> <i></i> <i></i> 5: <br/>

http://publicationslist.org/Lachenmeier/refid121 2012-01-31T13:02:22Z

Dirk W Lachenmeier, Mikko Salaspuro (2011) <i>Food Chem Toxicol</i> <i></i> <i></i> : <br/>

http://publicationslist.org/Lachenmeier/refid135 2012-01-31T13:02:54Z

An increasing body of evidence now implicates acetaldehyde as a major underlying factor for the carcinogenicity of alcoholic beverages and especially for oesophageal and oral cancer. Acetaldehyde associated with alcohol consumption is regarded as 'carcinogenic to humans' (IARC Group 1), with sufficient evidence available for the oesophagus, head and neck as sites of carcinogenicity. At present, re...<br/><br/>Dirk W Lachenmeier, Yulia B Monakhova (2011) <i>J Exp Clin Cancer Res</i> <i></i> <i></i> 30: <br/>

http://publicationslist.org/Lachenmeier/refid128 2012-01-31T13:02:22Z

A strategy for analyzing formaldehyde in beer, wine, spirits, and unrecorded alcohol was developed, and 508 samples from worldwide origin were analyzed. In the first step, samples are qualitatively screened using a simple colorimetric test with the purpald reagent, which is extremely sensitive for formaldehyde (detection limit 0.1 mg/L). 210 samples (41%) gave a positive purpald reaction. In the...<br/><br/>Julien A Jendral, Yulia B Monakhova, Dirk W Lachenmeier (2011) <i>Int J Anal Chem</i> <i></i> <i></i> 2011: <br/>

http://publicationslist.org/Lachenmeier/refid134 2012-01-31T13:02:54Z

According to the World Health Organization, the public health impact of illicit alcohol and informally produced alcohol should be reduced. This paper summarizes and evaluates the evidence base about policy and intervention options regarding unrecorded alcohol consumption.<br/><br/>Dirk W Lachenmeier, Benjamin J Taylor, Jürgen Rehm (2011) <i>Int J Drug Policy</i> <i></i> <i></i> 22: 2 153-160<br/>

http://publicationslist.org/Lachenmeier/refid132 2012-01-31T13:02:54Z

Nontargeted 400 MHz (13)C and (1)H nuclear magnetic resonance (NMR) spectroscopy was used in the context of food surveillance to reveal Pinus species whose nuts cause taste disturbance following their consumption, the so-called pine nut syndrome (PNS). Using principal component analysis, three groups of pine nuts were distinguished. PNS-causing products were found in only one of the groups, which ...<br/><br/>Helmut Kobler, Yulia B Monakhova, Thomas Kuballa, Christopher Tschiersch, Jeroen Vancutsem, Gerhard Thielert, Arne Mohring, Dirk W Lachenmeier (2011) <i>J Agric Food Chem</i> <i></i> <i></i> 59: 13 6877-6881<br/>

http://publicationslist.org/Lachenmeier/refid133 2012-01-31T13:02:54Z

Some European countries with high levels of unrecorded alcohol consumption have anomalously high rates of death attributable to liver cirrhosis. Hepatotoxic compounds in illegally produced spirits may be partly responsible. Based on a review of the evidence on the chemical composition and potential harm from unrecorded alcohol, the Alcohol Measures for Public Health Research Alliance (AMPHORA) pro...<br/><br/>Dirk W Lachenmeier, Kerstin Schoeberl, Fotis Kanteres, Thomas Kuballa, Eva-Maria Sohnius, Jürgen Rehm (2011) <i>Addiction</i> <i></i> <i></i> 106 Suppl 1: 20-30<br/>

http://publicationslist.org/Lachenmeier/refid129 2012-01-31T13:02:54Z

Acetaldehyde (ethanal) is a genotoxic carcinogen, which may occur naturally or as an added flavour in foods. We have developed an efficient method to analyze the compound in a wide variety of food matrices. The analysis is conducted using headspace (HS) gas chromatography (GC) with flame ionization detector. Using a robot autosampler, the samples are digested in full automation with simulated gast...<br/><br/>Michael Uebelacker, Dirk W Lachenmeier (2011) <i>J Autom Methods Manag Chem</i> <i></i> <i></i> 2011: <br/>

http://publicationslist.org/Lachenmeier/refid131 2012-01-31T13:02:54Z

Analytical methods based on spectroscopic techniques were developed and validated for the determination of diethyl phthalate (DEP) and polyhexamethylene guanidine (PHMG), which may occur in unrecorded alcohol. Analysis for PHMG was based on UV-VIS spectrophotometry after derivatization with Eosin Y and (1)H NMR spectroscopy of the DMSO extract. Analysis of DEP was performed with direct UV-VIS and ...<br/><br/>Yulia B Monakhova, Thomas Kuballa, Jenny Leitz, Dirk W Lachenmeier (2011) <i>Int J Anal Chem</i> <i></i> <i></i> 2011: <br/>

http://publicationslist.org/Lachenmeier/refid130 2012-01-31T13:02:54Z

In the WHO region Europe, the average unrecorded adult per capita alcohol consumption was 2.67 L pure ethanol in 2005, which is 22% of the total consumption of 12.20 L. Despite concerns about potential health harms from the chemical composition of unrecorded alcohol, there are surprisingly few data on the problem in the European Region. This study reports the results from the Alcohol Measures for ...<br/><br/>Dirk W Lachenmeier, Jenny Leitz, Kerstin Schoeberl, Thomas Kuballa, Irene Straub, Jürgen Rehm (2011) <i>Adicciones</i> <i></i> <i></i> 23: 2 133-140<br/>

http://publicationslist.org/Lachenmeier/refid112 2012-01-31T13:03:34Z

Thujone is a natural substance found in plants commonly used in foods and beverages, such as wormwood and sage, as well as in herbal medicines. The current limits for thujone in food products are based on short-term animal studies from the 1960s, which provided evidence for a threshold-based mechanism, yet only allowed for the derivation of preliminary values for acceptable daily intakes (ADI) bas...<br/><br/>Dirk W Lachenmeier, Michael Uebelacker (2010) <i>Regul Toxicol Pharmacol</i> <i></i> <i></i> 58: 3 437-443<br/>

http://publicationslist.org/Lachenmeier/refid109 2010-04-03T12:25:04Z

ABSTRACT: BACKGROUND: Ever since Gay-Lussac's time, the alcoholic strength by volume (% vol) has been determined by using densimetric measurements. The typical reference procedure involves distillation followed by pycnometry, which is comparably labour-intensive and therefore expensive. At present, infrared (IR) spectroscopy in combination with multivariate regression is widely applied as a screen...<br/><br/>Dirk W Lachenmeier, Rolf Godelmann, Markus Steiner, Bob Ansay, Jurgen Weigel, Gunther Krieg (2010) <i>Chem Cent J</i> <i></i> <i></i> 4: 1 <br/>

http://publicationslist.org/Lachenmeier/refid113 2012-01-31T13:03:34Z

In 2005, approximately half of all alcohol consumption in Ukraine was unrecorded. This paper investigates the chemical composition of unrecorded and low-cost alcohol, including a toxicological evaluation. A sample of alcohol products (n=78) from both recorded and unrecorded sources was obtained mainly from eastern Ukraine, and chemically analyzed. Analysis entailed alcoholic strength, levels of vo...<br/><br/>Dirk W Lachenmeier, Andriy V Samokhvalov, Jenny Leitz, Kerstin Schoeberl, Thomas Kuballa, Igor V Linskiy, Oleksandr I Minko, Jürgen Rehm (2010) <i>Food Chem Toxicol</i> <i></i> <i></i> 48: 10 2842-2847<br/>

http://publicationslist.org/Lachenmeier/refid108 2010-10-31T08:50:09Z

D W Lachenmeier (2010) <i>Br Dent J</i> <i></i> <i></i> 208: 3 95-96<br/>

http://publicationslist.org/Lachenmeier/refid97 2010-04-03T12:25:03Z

Seeds of the opium poppy plant are legally sold and widely consumed as food. Due to contamination during harvesting, the seeds can contain morphine and other opiate alkaloids. The objective of this study is to review the toxicology of poppy seed foods regarding influence on opiate drug tests. Computer-assisted literature review resulted in 95 identified references. Normal poppy seed consumption is...<br/><br/>Dirk W Lachenmeier, Constanze Sproll, Frank Musshoff (2010) <i>Ther Drug Monit</i> <i></i> <i></i> 32: 1 11-18<br/>

http://publicationslist.org/Lachenmeier/refid116 2012-01-31T13:03:34Z

The medical use of the wormwood plant Artemisia absinthium L. dates back to at least Roman times, while during the last century this tradition was seemingly on the decline due to fears of absinthism, a syndrome allegedly caused by the wormwood-flavoured spirit absinthe and more specifically as a result of thujone, a monoterpene ketone often present in the essential oil of wormwood. If threshold co...<br/><br/>Dirk W Lachenmeier (2010) <i>J Ethnopharmacol</i> <i></i> <i></i> 131: 1 224-227<br/>

http://publicationslist.org/Lachenmeier/refid98 2010-10-31T08:51:24Z

Benzene was previously detected as a heat-induced contaminant in infant carrot juices. This study shows that carrot juice contains substances such as beta-carotene, phenylalanine or terpenes that may act as precursors for benzene formation during food processing. As benzene exposure has been associated with childhood leukaemia and other cancers, this study aimed to provide a quantitative risk asse...<br/><br/>Dirk W Lachenmeier, Thomas Kuballa, Helmut Reusch, Constanze Sproll, Mathilde Kersting, Ute Alexy (2010) <i>Food Chem Toxicol</i> <i></i> <i></i> 48: 1 291-297<br/>

http://publicationslist.org/Lachenmeier/refid114 2012-01-31T13:03:34Z

This contribution aims to examine systematically the evidence on the impact of the quality of unrecorded alcohol products on health consequences.<br/><br/>Jürgen Rehm, Fotis Kanteres, Dirk W Lachenmeier (2010) <i>Drug Alcohol Rev</i> <i></i> <i></i> 29: 4 426-436<br/>

http://publicationslist.org/Lachenmeier/refid136 2012-01-31T13:02:54Z

Furan is a possible human carcinogen regularly occurring in commercially jarred complementary foods. This paper will provide a detailed exposure assessment for babies consuming these foods considering different intake scenarios. The occurrence data on furan in complementary foods were based on our own headspace-gas chromatography/mass spectrometry (HS-GC/MS) analytical results (n = 286). The a...<br/><br/>Dirk W Lachenmeier, Elena Maser, Thomas Kuballa, Helmut Reusch, Mathilde Kersting, Ute Alexy (2010) <i>Matern Child Nutr</i> <i></i> <i></i> : <br/>

http://publicationslist.org/Lachenmeier/refid117 2010-10-31T08:50:09Z

BACKGROUND: Ethyl carbamate (EC) is a multi-site carcinogen in experimental animals and probably carcinogenic to humans (IARC group 2A). Traces of EC below health-relevant ranges naturally occur in several fermented foods and beverages, while higher concentrations above 1 mg/l are regularly detected in only certain spirits derived from cyanogenic plants. In Brazil this concerns the sugarcane spiri...<br/><br/>Dirk W Lachenmeier, Maria C P Lima, Ian C C Nóbrega, José A P Pereira, Florence Kerr-Corrêa, Fotis Kanteres, Jürgen Rehm (2010) <i>BMC Cancer</i> <i></i> <i></i> 10: <br/>

http://publicationslist.org/Lachenmeier/refid115 2012-01-31T13:03:34Z

Dirk W Lachenmeier, Jürgen Rehm (2010) <i>Alcohol Clin Exp Res</i> <i></i> <i></i> 34: 10 1671-2; author reply 1673-4<br/>

http://publicationslist.org/Lachenmeier/refid95 2009-12-26T15:53:17Z

Dirk W Lachenmeier, Fotis Kanteres, Jürgen Rehm (2009) <i>Metabolism</i> <i></i> <i></i> 58: 6 889-890<br/>

http://publicationslist.org/Lachenmeier/refid94 2009-12-26T15:53:17Z

AIMS: In addition to being produced in ethanol metabolism, acetaldehyde occurs naturally in alcoholic beverages. Limited epidemiological evidence points to acetaldehyde as an independent risk factor for cancer during alcohol consumption, in addition to the effects of ethanol. This study aims to estimate human exposure to acetaldehyde from alcoholic beverages and provide a quantitative risk assessm...<br/><br/>Dirk W Lachenmeier, Fotis Kanteres, Jürgen Rehm (2009) <i>Addiction</i> <i></i> <i></i> 104: 4 533-550<br/>

http://publicationslist.org/Lachenmeier/refid96 2010-04-03T12:25:04Z

BACKGROUND: Phthalates are synthetic compounds with a widespread field of applications. For example, they are used as plasticizers in PVC plastics and food packaging, or are added to personal care products. Diethyl phthalate (DEP) may be used to denature alcohol, e.g., for cosmetic purposes. Public health concerns of phthalates include carcinogenic, teratogenic, hepatotoxic and endocrine effects. ...<br/><br/>Jenny Leitz, Thomas Kuballa, Jürgen Rehm, Dirk W Lachenmeier (2009) <i>PLoS One</i> <i></i> <i></i> 4: 12 <br/>

http://publicationslist.org/Lachenmeier/refid85 2009-03-28T20:29:53Z

AIMS: The rates of alcohol-attributable mortality in Lithuania and Hungary have been shown to be higher than those in most other European countries. Quality of alcohol products is investigated as a possible explanation. METHODS: In a descriptive pilot study, a convenience sample of alcohol products was collected from local city markets in both countries (Lithuania n = 10, Hungary n = 15) and chemi...<br/><br/>Dirk W Lachenmeier, Bart Sarsh, Jürgen Rehm (2009) <i>Alcohol Alcohol</i> <i></i> <i></i> 44: 1 93-102<br/>

http://publicationslist.org/Lachenmeier/refid87 2009-01-24T13:33:44Z

Mercury is an environmental contaminant that appears in different chemical forms. Organic forms of mercury, such as methylmercury, can occur in marine organisms like fish and shellfish and are far more toxic than the inorganic form. It is therefore vital to have refined analytical methods for the different mercuric species in order to evaluate the potential risk for seafood consumers. The aim of o...<br/><br/>T Kuballa, E Leonhardt, K Schoeberl, D W Lachenmeier (2009) <i>EUROPEAN FOOD RESEARCH AND TECHNOLOGY</i> <i></i> <i></i> 228: 30 425-431<br/>

http://publicationslist.org/Lachenmeier/refid91 2009-12-26T15:53:17Z

AIMS: To describe the consumption, distribution, production and chemical composition of alcohol, including cuxa (pronounced 'coo sha'), in Nahualá, a highland Mayan municipality in Guatemala. Cuxa is a sugarcane-derived spirit, in part produced clandestinely, that has been distributed in the community for several decades. METHODS: Key informant interviews with alcohol distributors and consumers, ...<br/><br/>Fotis Kanteres, Dirk W Lachenmeier, Jürgen Rehm (2009) <i>Addiction</i> <i></i> <i></i> 104: 5 752-759<br/>

http://publicationslist.org/Lachenmeier/refid92 2010-04-03T12:25:55Z

Dirk W Lachenmeier, Fotis Kanteres, Jürgen Rehm (2009) <i>Alcohol Clin Exp Res</i> <i></i> <i></i> 33: 5 759-760<br/>

http://publicationslist.org/Lachenmeier/refid93 2009-12-26T15:53:17Z

Research was conducted to ascertain whether analyses of vintage absinthe samples represent their original composition in the early 1900s. Absinthe stored in traditional green glass bottles and irradiated with ultraviolet light for up to 200 h exhibited unchanged composition. Samples stored in clear glass exhibited an 18% reduction in beta-thujone content and a concurrent decoloration. These experi...<br/><br/>Dirk W Lachenmeier, David Nathan-Maister, Theodore A Breaux, Thomas Kuballa (2009) <i>J Agric Food Chem</i> <i></i> <i></i> 57: 7 2782-2785<br/>

http://publicationslist.org/Lachenmeier/refid110 2010-10-31T08:50:09Z

The recent melamine crisis in China has pointed out a serious deficiency in current food control systems, namely, they specifically focus on selected known compounds. This targeted approach allowed the presence of melamine in milk products to be overlooked for a considerable time. To avoid such crises in the future, we propose that nontargeted screening methods need to be developed and applied. To...<br/><br/>Dirk W Lachenmeier, Eberhard Humpfer, Fang Fang, Birk Schütz, Peter Dvortsak, Constanze Sproll, Manfred Spraul (2009) <i>J Agric Food Chem</i> <i></i> <i></i> 57: 16 7194-7199<br/>

http://publicationslist.org/Lachenmeier/refid106 2009-12-26T15:53:17Z

Increasing evidence suggests that acetaldehyde, the first and genotoxic metabolite of ethanol, mediates the carcinogenicity of alcoholic beverages. Ethanol is also contained in a number of ready-to-use mouthwashes typically between 5 and 27% vol. An increased risk of oral cancer has been discussed for users of such mouthwashes; however, epidemiological evidence had remained inconclusive. This stud...<br/><br/>Dirk W Lachenmeier, Szidönia Gumbel-Mako, Eva-Maria Sohnius, Andrea Keck-Wilhelm, Evamaria Kratz, Gerd Mildau (2009) <i>Int J Cancer</i> <i></i> <i></i> 125: 3 730-735<br/>

http://publicationslist.org/Lachenmeier/refid99 2009-12-26T15:52:25Z

Dirk W Lachenmeier (2009) <i>Lancet</i> <i></i> <i></i> 374: 9694 <br/>

http://publicationslist.org/Lachenmeier/refid107 2009-12-26T15:53:17Z

Ethyl carbamate (EC) is a recognized genotoxic carcinogen, with widespread occurrence in fermented foods and beverages. No data on its occurrence in alcoholic beverages from Mexico or Central America is available. Samples of agave spirits including tequila, mezcal, bacanora and sotol (n=110), and of the sugarcane spirit cuxa (n=16) were purchased in Mexico and Guatemala, respectively, and analyzed...<br/><br/>Dirk W Lachenmeier, Fotis Kanteres, Thomas Kuballa, Mercedes G López, Jürgen Rehm (2009) <i>Int J Environ Res Public Health</i> <i></i> <i></i> 6: 1 349-360<br/>

http://publicationslist.org/Lachenmeier/refid104 2009-12-26T15:52:25Z

A rapid HS-SPME-GC-MS (headspace solid-phase microextraction-gas chromatography-mass spectrometry) method has been developed for determination of menthone, isomenthone, neomenthol and menthol in serum samples with and without enzymatic cleavage. These flavour compounds are characteristic markers for consumption of peppermint liqueurs as well as certain digestif bitters, herbal and bitter liqueurs....<br/><br/>Katja Schulz, Martin Bertau, Katja Schlenz, Steffen Malt, Jan Dressler, Dirk W Lachenmeier (2009) <i>Anal Chim Acta</i> <i></i> <i></i> 646: 1-2 128-140<br/>

http://publicationslist.org/Lachenmeier/refid105 2009-12-26T15:52:25Z

Dirk W Lachenmeier, Jürgen Rehm (2009) <i>Addiction</i> <i></i> <i></i> 104: 6 875-877<br/>

http://publicationslist.org/Lachenmeier/refid100 2009-12-26T15:52:25Z

Four homemade (artisanally manufactured and unrecorded) and seven commercial (industrially manufactured and taxed) alcohol products from Vietnam were collected and chemically analyzed for toxicologically relevant substances. The majority of both types had alcohol contents between 30 and 40% vol. Two homemade samples contained significantly higher concentrations of 45 and 50% vol. In one of these h...<br/><br/>Dirk W Lachenmeier, Pham Thi Hoang Anh, Svetlana Popova, Jürgen Rehm (2009) <i>Int J Environ Res Public Health</i> <i></i> <i></i> 6: 8 2090-2101<br/>

http://publicationslist.org/Lachenmeier/refid103 2010-04-03T12:25:55Z

BACKGROUND: The research aimed to study the quality of cheap alcohol products in Poland. These included unrecorded alcohols (i.e., home-produced or illegally imported), estimated to constitute more than 25% of total consumption and fruit wines. METHODS: A sample of alcohol products (n = 52) was collected from local markets and chemical analyses were conducted. The parameters studied were alcoholic...<br/><br/>Dirk W Lachenmeier, Sebastian Ganss, Bogumil Rychlak, Jürgen Rehm, Urszula Sulkowska, Michał Skiba, Witold Zatonski (2009) <i>Alcohol Clin Exp Res</i> <i></i> <i></i> 33: 10 1757-1769<br/>

http://publicationslist.org/Lachenmeier/refid101 2009-12-26T15:52:25Z

There is a lack of knowledge regarding the composition, production, distribution, and consumption of artisanal alcohol, particularly in the developing world. In Nahualá, an indigenous Mayan municipality located in highland Guatemala, heavy alcohol consumption appears to have had a significant negative impact on health, a major role in cases of violence and domestic abuse, and a link to street hab...<br/><br/>Fotis Kanteres, Jürgen Rehm, Dirk W Lachenmeier (2009) <i>Sci Total Environ</i> <i></i> <i></i> 407: 22 5861-5868<br/>

http://publicationslist.org/Lachenmeier/refid102 2010-10-31T08:51:24Z

Furan is a possible human carcinogen (IARC group 2B) with widespread occurrence in many types of foods. In this study, a survey of furan contamination in 230 commercially jarred ready-to-eat infant food products was conducted using headspace sampling in combination with gas chromatography and mass spectrometry (HS-GC/MS) with a detection limit of 0.2 microg kg(-1). The incidence of furan contamina...<br/><br/>Dirk W Lachenmeier, Helmut Reusch, Thomas Kuballa (2009) <i>Food Addit Contam Part A Chem Anal Control Expo Risk Assess</i> <i></i> <i></i> 26: 6 776-785<br/>

http://publicationslist.org/Lachenmeier/refid77 2008-11-20T08:25:31Z

Acetaldehyde is a volatile compound naturally found in alcoholic beverages, and it is regarded as possibly being carcinogenic to humans (IARC Group 2B). Acetaldehyde formed during ethanol metabolism is generally considered as a source of carcinogenicity in alcoholic beverages. However, no systematic data is available about its occurrence in alcoholic beverages and the carcinogenic potential of hum...<br/><br/>Dirk W Lachenmeier, Eva-Maria Sohnius (2008) <i>Food Chem Toxicol</i> <i></i> <i></i> 46: 8 2903-2911<br/>

http://publicationslist.org/Lachenmeier/refid76 2009-01-24T13:26:32Z

A survey of benzene contamination of 451 beverage samples, using headspace sampling combined with gas chromatography and mass spectrometry (HS-GC/MS) with a quantification limit of 0.13 microg l(-1), was conducted. Artefactual benzene formation during headspace sampling was excluded by gentle heating at 50 degrees C only and adjustment of sample pH to 10. The incidence of benzene contamination in ...<br/><br/>Dirk W Lachenmeier, Helmut Reusch, Constanze Sproll, Kerstin Schoeberl, Thomas Kuballa (2008) <i>Food Addit Contam Part A Chem Anal Control Expo Risk Assess</i> <i></i> <i></i> 25: 10 1216-1224<br/>

http://publicationslist.org/Lachenmeier/refid78 2008-11-20T08:25:31Z

In the analysis of food additives, past emphasis was put on the development of chromatographic techniques to separate target components from a complex matrix. Especially in the case of artificial food colors, direct spectrophotometric measurement was seen to lack in specificity due to a high spectral overlap between different components. Multivariate curve resolution (MCR) may be used to overcome ...<br/><br/>Dirk W Lachenmeier, Waltraud Kessler (2008) <i>J Agric Food Chem</i> <i></i> <i></i> 56: 14 5463-5468<br/>

http://publicationslist.org/Lachenmeier/refid79 2008-08-02T17:52:25Z

Borderline products, which are products that fall into categories between foods, cosmetics and pharmaceuticals, are found more and more in grey areas of the internet. Currently there are no adequate methods for efficient surveillance of internet marketing for these products by the governmental food control authorities. The aim of this study, which was initiated by the 'Ministerium fur Ernahrung un...<br/><br/>S Löbell-Behrends, S Maixner, E Kratz, M Kohl-Himmelseher, H Bauer-Aymanns, G Marx, D W Lachenmeier (2008) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 104: 6 265-270<br/>

http://publicationslist.org/Lachenmeier/refid29 2008-08-02T17:38:51Z

Conductivity measurement is introduced as a rapid, simple and cheap way to identify counterfeit vodka. It was found that the conductivity of vodka derives exclusively from its content of inorganic anions which were previously suggested as markers for vodka authenticity using ion chromatographic determination. The conductivity of vodka is very stable between different batches of bottle filling of t...<br/><br/>D W Lachenmeier, B Schmidt, T Bretschneider (2008) <i>MICROCHIMICA ACTA</i> 160: 1-2 283-289<br/>

http://publicationslist.org/Lachenmeier/refid73 2008-11-20T08:25:31Z

In the discussion about thujone as possible toxic constituent of the wormwood-containing alcoholic beverage absinthe, the dose-response-relationship is frequently ignored. The effects of absinthe are very often attributed only to thujone, an association that is not scientifically proven. Especially the alleged psychotropic effects of thujone are scientifically unproven. However, the question about...<br/><br/>Dirk W Lachenmeier (2008) <i>Med Monatsschr Pharm</i> <i></i> <i></i> 31: 3 101-106<br/>

http://publicationslist.org/Lachenmeier/refid74 2008-11-20T08:25:31Z

Thirteen samples of authentic absinthe dating from the preban era (i.e., prior to 1915) were analyzed for parameters that were hypothesized as contributing to the toxicity of the spirit, including naturally occurring herbal essences (thujone, pinocamphone, fenchone), methanol, higher alcohols, copper, and antimony. The total thujone content of preban absinthe was found to range between 0.5 and 48....<br/><br/>Dirk W Lachenmeier, David Nathan-Maister, Theodore A Breaux, Eva-Maria Sohnius, Kerstin Schoeberl, Thomas Kuballa (2008) <i>J Agric Food Chem</i> <i></i> <i></i> 56: 9 3073-3081<br/>

http://publicationslist.org/Lachenmeier/refid75 2008-05-09T12:45:28Z

Higher alcohols occur naturally in alcoholic beverages as by-products of alcoholic fermentation. Recently, concerns have been raised about the levels of higher alcohols in surrogate alcohol (i.e., illicit or home-produced alcoholic beverages) that might lead to an increased incidence of liver diseases in regions where there is a high consumption of such beverages. In contrast, higher alcohols are ...<br/><br/> DW Lachenmeier, S Haupt, K Schulz (2008) <i>Regul Toxicol Pharmacol</i> 50: 3 313-321<br/>

http://publicationslist.org/Lachenmeier/refid1 2008-11-20T08:25:31Z

Dirk W Lachenmeier, David Nathan-Maister (2008) <i>Int J Epidemiol</i> <i></i> <i></i> 37: 1 217-8; author reply 219<br/>

http://publicationslist.org/Lachenmeier/refid80 2008-08-02T17:48:49Z

J Rehm, D W Lachenmeier (2008) <i>ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH</i> <i></i> <i></i> 32: 6 293A-293A<br/>

http://publicationslist.org/Lachenmeier/refid88 2009-01-24T13:35:48Z

There is a large variety of food products intended for athletes and sportsmen on the market. These products are often advertised with claims such as enhancement of performance, ability for regeneration, or even with an influence on hormonal balance. In recent years, the number of such products marketed on the internet has been considerably increased. In this study, we have examined the marketing o...<br/><br/>S Lobell-Behrends, D Schweizer, M Kohl-Himmel-Seher, S Maixner, G Marx, D W Lachenmeier (2008) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 104: 65 415-422<br/>

http://publicationslist.org/Lachenmeier/refid81 2008-08-02T17:48:49Z

Coumarin is a component of natural flavourings including cassia, which is widely used in foods and pastries. The toxicity of coumarin has raised some concerns and food safety authorities have set a maximum limit of 2 mg/kg for foods and beverages in general, and a maximum level of 10 mg/l for alcoholic beverages. An efficient method for routine analysis of coumarin is liquid chromatography with di...<br/><br/>C Sproll, W Ruge, C Andlauer, R Godelmann, D W Lachenmeier (2008) <i>FOOD CHEMISTRY</i> <i></i> <i></i> 109: 2 462-469<br/>

http://publicationslist.org/Lachenmeier/refid90 2009-01-24T13:38:38Z

The letter from Mike Stapleton needs rebuttal, as it contains a number of factual errors (C&EN, June 16, page 9). The first and foremost misrepresentation is the boiling point of thujone, which the letter states to be 84 °C. In fact, this is obviously a boiling point measured at reduced pressure (most likely the "bp17" according to the "Merck Index"). A current search in SciFinder shows that the ...<br/><br/>D Lachenmeier (2008) <i>CHEMICAL & ENGINEERING NEWS</i> 86: 0 7-8<br/>

http://publicationslist.org/Lachenmeier/refid86 2009-01-24T13:33:44Z

Fourier transform infrared (FTIR) spectroscopy allows fast throughput screening of beverages (less than 2 min per sample). Using partial least squares (PLS) regression, it was demonstrated that relative density and alcohol content, which have previously been calibrated only for extract-free spirits, can also be determined in highly viscous liqueur samples. In addition, total dry extract (TDE) was ...<br/><br/>U Arzberger, D W Lachenmeier (2008) <i>FOOD ANALYTICAL METHODS</i> <i></i> <i></i> 1: 25 18-22<br/>

http://publicationslist.org/Lachenmeier/refid89 2009-01-24T13:33:44Z

E Humpfer, H Schafer, J Vervoort, G Hofmann, M Mooertter, S Keller, M Spraul, D Lachenmeier, P Rinke, I Duarte (2008) <i>PLANTA MEDICA</i> <i></i> <i></i> 74: 0 900-900<br/>

http://publicationslist.org/Lachenmeier/refid84 2008-11-20T08:32:57Z

A rapid headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) method has been developed for the determination of eugenol in serum samples after enzymatic cleavage. Eugenol is a characteristic marker for the consumption of certain alcoholic beverages including some digestif bitters and herbal liqueurs as well as wood-cask-aged spirits. This method enables the de...<br/><br/> Schulz, Schlenz, Malt, Metasch, Römhild, Dreßler, Lachenmeier (2008) <i>J Chromatogr A</i> 1211: 1-2 113-119<br/>

http://publicationslist.org/Lachenmeier/refid82 2008-08-02T17:51:36Z

A novel method using fluorescence-marked gene probes is introduced into beer analysis in the context of official food control. Two commercial test kits for the detection of Lactobacilli/Pediococci and Megasphaera/Pectinatus beer spoilage bacteria were used and compared to classical plating techniques. The new method was found to be very sensitive and convenient for the identification and assessmen...<br/><br/>D Noack, C Knodl, D W Lachenmeier (2008) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 104: 2 65-69<br/>

http://publicationslist.org/Lachenmeier/refid83 2008-11-20T08:26:44Z

ABSTRACT: Ethanol is widely used in all kinds of products with direct exposure to the human skin (e.g. medicinal products like hand disinfectants in occupational settings, cosmetics like hairsprays or mouthwashes, pharmaceutical preparations, and many household products). Contradictory evidence about the safety of such topical applications of the alcohol can be found in the scientific literature, ...<br/><br/> Lachenmeier (2008) <i>J Occup Med Toxicol</i> 3: 1 26<br/>

http://publicationslist.org/Lachenmeier/refid31 2008-02-24T15:55:22Z

Due to major concerns about morphine present in poppy seed intended for use in food, the establishment of maximum limits is currently discussed and options to reduce its content are searched. With the aim to propose guidelines for consumers and bakeries about minimization of the morphine content in poppy seed, the kinetics of morphine degradation during grinding as well as the possibility to reduc...<br/><br/>C Sproll, R C Perz, R Buschmann, D W Lachenmeier (2007) <i>EUROPEAN FOOD RESEARCH AND TECHNOLOGY</i> 226: 1-2 307-310<br/>

http://publicationslist.org/Lachenmeier/refid32 2008-04-25T13:02:46Z

A discrepancy in the magnitude of thujone concentrations in distilled pre-ban absinthe has existed until now. Concentrations of 260 mg L-1 were derived at by theoretical calculations. Tests of authentic pre-ban absinthes and studies concerning absinthes produced according to historic recipes found concentrations below 10 mg L-1. In this study, the behaviour of thujone during distillation was studi...<br/><br/>D W Lachenmeier, T Kuballa (2007) <i>JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE</i> 87: 11 2147-2151<br/>

http://publicationslist.org/Lachenmeier/refid37 2008-02-24T15:42:06Z

The media coverage about absinthe, a bitter spirit containing wormwood (Artemisia absinthum L.), continues to repeat unsubstantiated myths and legends and the public is systematically misinformed. Especially, the theory about a significant thujone content in absinthe must be put into perspective as there are a number of different wormwood chemotypes with a large variance in thujone content (0-70.6...<br/><br/>D W Lachenmeier, D Nathan-Maister (2007) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 103: 6 255-262<br/>

http://publicationslist.org/Lachenmeier/refid42 2008-05-09T12:27:39Z

Absinthe is a spirit drink that owes its bitter taste to substances found in the wormwood plant (Artemisia absinthium L.). The prohibition against absinthe has recently been annulled, giving rise to numerous inferior products that lack the organoleptic characteristics of wormwood. The monoterpene thujone, which occurs in the essential oil fraction of wormwood, has previously been used as a marker ...<br/><br/>D W Lachenmeier (2007) <i>FOOD RESEARCH INTERNATIONAL</i> 40: 1 167-175<br/>

http://publicationslist.org/Lachenmeier/refid39 2008-02-24T15:42:41Z

Since 2005, the official food surveillance in Baden-Wurttemberg (Germany) has continously been analysing the contents of opiate alkaloids in poppy seeds and foods made thereof. Ready-made bodies, poppy seeds from bakeries, and poppy seeds dedicated directly to the consumer were investigated. In 2005 opiate contents especially morphine were high enough to cause adverse health effects in several cas...<br/><br/>R C Perz, C Sproll, D W Lachenmeier, R Buschmann (2007) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 103: 5 193-196<br/>

http://publicationslist.org/Lachenmeier/refid36 2008-02-24T15:40:39Z

In February 2007, the International Agency for Research on Cancer (IARC) has reassessed the carcinogenicity of alcoholic beverages within its monographs programme. Ethanol in alcoholic beverages was classified as "carcinogenic to humans" (Group 1). Many studies have consistently shown that regular alcohol consumption is causally related with an increased risk for cancer of the oral cavity, pharynx...<br/><br/>D W Lachenmeier (2007) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 103: 7 307-311<br/>

http://publicationslist.org/Lachenmeier/refid5 2007-10-05T15:24:22Z

The use of headspace adsorbent traps in combination with gas chromatography was evaluated for the determination of volatile constituents (i.e. higher alcohols and other congeners of alcoholic fermentation) in spirits. The headspace trap technology comprises an enhanced static headspace system that allows enrichment and focusing of analytes on adsorbent traps prior to gas chromatographic separation...<br/><br/>Katja Schulz, Jan Dressler, Eva-Maria Sohnius, Dirk W Lachenmeier (2007) <i>J Chromatogr A</i> <i></i> <i></i> 1145: 1-2 204-209<br/>

http://publicationslist.org/Lachenmeier/refid3 2008-11-20T08:25:31Z

Heat-induced food contaminants have attracted attention of both the scientific community and the public in recent years. The presence of substances considered possibly or probably carcinogenic to humans has triggered an extensive debate on the healthiness of even staple foods. In that respect, acrylamide, furan and chloropropanols are the main substances of concern. Their widespread occurrence in ...<br/><br/>Thomas Wenzl, Dirk W Lachenmeier, Vural Gökmen (2007) <i>Anal Bioanal Chem</i> <i></i> <i></i> 389: 1 119-137<br/>

http://publicationslist.org/Lachenmeier/refid2 2008-11-20T08:25:31Z

BACKGROUND: Consumption of surrogate alcohols (i.e., nonbeverage alcohols and illegally produced alcohols) was shown to impact on different causes of death, not only poisoning or liver disease, and appears to be a major public health problem in Russia and elsewhere. METHODS: A computer-assisted literature review on chemical composition and health consequences of "surrogate alcohol" was conducted a...<br/><br/>Dirk W Lachenmeier, Jürgen Rehm, Gerhard Gmel (2007) <i>Alcohol Clin Exp Res</i> <i></i> <i></i> 31: 10 1613-1624<br/>

http://publicationslist.org/Lachenmeier/refid4 2007-10-05T15:24:22Z

The etiopathology of absinthe dependence was previously attributed to the effects of the wormwood constituent thujone. Current research proves otherwise. Foremost, it must be considered that the wormwood plant shows a very large variance in quantity of thujone (0 - 70 % in essential oil) dependent on chemo type and cultivation area. Thus, absinthe does not contain thujone in general. Experimental ...<br/><br/>D W Lachenmeier (2007) <i>Fortschr Neurol Psychiatr</i> <i></i> <i></i> 75: 5 306-308<br/>

http://publicationslist.org/Lachenmeier/refid43 2008-05-09T12:30:02Z

Fourier Transform Infrared (FTIR) spectroscopy in combination with multivariate data analysis is introduced for the quality control and authenticity assessment of spirit drinks and beer in official food control. The spectra were measured using a FTIR interferometer, which is purpose-built for the analysis of alcoholic beverages and includes an injection unit for liquids with automatic thermostatin...<br/><br/>D W Lachenmeier (2007) <i>FOOD CHEMISTRY</i> 101: 2 825-832<br/>

http://publicationslist.org/Lachenmeier/refid6 2008-11-20T08:25:31Z

Fermented fruit and beverages frequently contain ethyl carbamate (EC), a potentially carcinogenic compound that can be formed by the reaction of urea with ethanol. Both are produced by the yeast Saccharomyces cerevisiae with ethanol as the major end product of hexose fermentation and urea as a by-product in arginine catabolism. In spirit production, EC can also be derived from cyanide introduced b...<br/><br/>Beatus Schehl, Thomas Senn, Dirk W Lachenmeier, Rosaura Rodicio, Jürgen J Heinisch (2007) <i>Appl Microbiol Biotechnol</i> <i></i> <i></i> 74: 4 843-850<br/>

http://publicationslist.org/Lachenmeier/refid7 2009-01-24T13:26:32Z

So-called energy drinks with very high amounts of taurine (up to 4000 mg/l are usually granted by certificates of exemption) are increasingly offered on the market. To control the currently valid maximum limits of taurine in energy drinks, a simple and rapid analytical method is required to use it routinely in food monitoring. In this article, we describe a fast and efficient analytical method (FT...<br/><br/>S Triebel, C Sproll, H Reusch, R Godelmann, D W Lachenmeier (2007) <i>Amino Acids</i> <i></i> <i></i> 33: 3 451-457<br/>

http://publicationslist.org/Lachenmeier/refid30 2008-02-24T15:40:05Z

The main components of the Southern German specialty black forest gateau (black forest cherry cake) are pastry base, filling with whipped cream or butter cream, cherries and cherry spirit as well as chocolate shavings for decoration. The cherry spirit is often added to the cream, may be contained in the filling, or is sometimes used to saturate the pastry base. The cake should contain so much cher...<br/><br/>D W Lachenmeier, E M Sohnius, K Zipfel (2007) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 103: 12 557-561<br/>

http://publicationslist.org/Lachenmeier/refid72 2008-02-24T16:00:59Z

Robert Baan, Kurt Straif, Yann Grosse, Béatrice Secretan, Fatiha El Ghissassi, Véronique Bouvard, Andrea Altieri, Vincent Cogliano, WHO International Agency for Research on Cancer Monograph Working Group (2007) <i>Lancet Oncol</i> 8: 4 292-293<br/>

http://publicationslist.org/Lachenmeier/refid10 2008-02-24T16:13:28Z

ABSTRACT : Absinthe, a bitter spirit containing wormwood (Artemisia absinthium L.), was banned at the beginning of the 20th century as consequence of its supposed unique adverse effects. After nearly century-long prohibition, absinthe has seen a resurgence after recent de-restriction in many European countries. This review provides information on the history of absinthe and one of its constituent,...<br/><br/>S Padosch, D Lachenmeier, L Kröner (2006) <i>Subst Abuse Treat Prev Policy</i> 1: 14 <br/>

http://publicationslist.org/Lachenmeier/refid11 2007-10-05T15:24:22Z

A large collection (n = 95) of Mexican Agave spirits with protected appellations of origin (Tequila, Mezcal, Sotol, and Bacanora) was analyzed using ion and gas chromatography. Because of their production from oxalate-containing plant material, all Agave spirits contained significant concentrations of oxalate (0.1-9.7 mg/L). The two Tequila categories ("100% Agave" and "mixed") showed differences ...<br/><br/>Dirk W Lachenmeier, Eva-Maria Sohnius, Rainer Attig, Mercedes G López (2006) <i>J Agric Food Chem</i> <i></i> <i></i> 54: 11 3911-3915<br/>

http://publicationslist.org/Lachenmeier/refid12 2007-10-05T15:24:22Z

A fully automated procedure using headspace solid-phase microextraction (HS-SPME) followed by gas chromatographic/tandem mass spectrometric (GC/MS/MS) detection was developed for the determination of the toxic contaminant ethyl carbamate (EC) in stone-fruit spirits. After addition of deuterated internal standard, the optimised HS-SPME extraction with carbowax/divinylbenzene fibres (30 min at 70 de...<br/><br/>Dirk W Lachenmeier, Uta Nerlich, Thomas Kuballa (2006) <i>J Chromatogr A</i> <i></i> <i></i> 1108: 1 116-120<br/>

http://publicationslist.org/Lachenmeier/refid17 2007-10-05T15:24:22Z

Habitual abuse of the wormwood spirit absinthe was described in the 19th and 20th centuries as a cause for the mental disorder "absinthism" including the symptoms hallucinations, sleeplessness and convulsions. A controversial discussion is going on if thujone, a characteristic component of the essential oil of the wormwood plant Artemisia absinthium L., is responsible for absinthism, or if it was ...<br/><br/>Dirk W Lachenmeier, J Emmert, T Kuballa, G Sartor (2006) <i>Forensic Sci Int</i> <i></i> <i></i> 158: 1 1-8<br/>

http://publicationslist.org/Lachenmeier/refid13 2007-10-05T15:24:22Z

Urine as well as head and pubic hair samples from drug abusers were analysed for opiates, cocaine and its metabolites, amphetamines, methadone and cannabinoids. Urine immunoassay results and the results of hair tests by means of gas chromatography-mass spectrometry were compared to the self-reported data of the patients in an interview protocol. With regard to the study group, opiate abuse was cla...<br/><br/>F Musshoff, F Driever, K Lachenmeier, D W Lachenmeier, M Banger, B Madea (2006) <i>Forensic Sci Int</i> <i></i> <i></i> 156: 2-3 118-123<br/>

http://publicationslist.org/Lachenmeier/refid44 2008-02-24T15:43:24Z

Two basic categories of the spirit drink Tequila can be distinguished according to Mexican law. For the high quality category "Tequila 100% de Agave" only pure agave juice is allowed to be fermented and distilled. Otherwise, the product is a "Mixto-Tequila", which is manufactured by adding up to 49% of sugar to the Agave wort. The sensory analysis using ranking methods showed significant differenc...<br/><br/>D W Lachenmeier (2006) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 102: 9 400-404<br/>

http://publicationslist.org/Lachenmeier/refid9 2007-10-05T15:24:22Z

The opiate alkaloids present in poppy seed intended for use in food recently have raised major concerns. An efficient method for routine analysis of morphine and codeine using liquid chromatography in combination with tandem mass spectrometry on a triple quadrupole instrument (LC/MS/MS) was therefore developed. The optimal sample preparation was found to be cold extraction of 10 g of unground popp...<br/><br/>Constanze Sproll, Roland C Perz, Dirk W Lachenmeier (2006) <i>J Agric Food Chem</i> <i></i> <i></i> 54: 15 5292-5298<br/>

http://publicationslist.org/Lachenmeier/refid8 2007-10-05T15:24:22Z

The alcoholic beverage absinthe is recently experiencing a revival after a yearlong prohibition. This review article provides information on all aspects of this bitter spirit and its major components, especially wormwood (Artemisia absinthium L.), which contains the toxic monoterpene thujone. Over 100 references on historic and current literature are provided. The topics comprise the history of th...<br/><br/>Dirk W Lachenmeier, Stephan G Walch, Stephan A Padosch, Lars U Kröner (2006) <i>Crit Rev Food Sci Nutr</i> <i></i> <i></i> 46: 5 365-377<br/>

http://publicationslist.org/Lachenmeier/refid48 2008-05-09T12:32:02Z

An experimental design, in combination with oscillation-type densimetry is introduced as a novel procedure to optimise steam distillation for the determination of alcoholic strength in different types of alcoholic beverages. A central composite design was chosen to study the effects of variation in levels of receiver volume (25 and 50 ml), steam power (30-100%), distillation time (20-140 s) and sa...<br/><br/>D W Lachenmeier, S G Walch, W Kessler (2006) <i>EUROPEAN FOOD RESEARCH AND TECHNOLOGY</i> 223: 2 261-266<br/>

http://publicationslist.org/Lachenmeier/refid53 2008-02-24T15:44:41Z

The Noni plant Morinda citrifolia L. (Rubiaceae) is sold for various conjectural nutritional and health benefits. Methods using high-performance thin-layer chromatography (HPTLC) and headspace-solid-phase microextraction/gas chromatography/mass spectrometry (HS-SPME/GC/MS) to assess the authenticity of commercial Noni juices were developed in this study, allowing differentiating between authentic ...<br/><br/>K Lachenmeier, F Musshoff, B Madea, H Reusch, D W Lachenmeier (2006) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 102: 2 58-61<br/>

http://publicationslist.org/Lachenmeier/refid50 2008-02-24T15:44:13Z

Ethyl carbamate (EC) is naturally found especially in stone-fruit spirits in relatively high concentrations and has genotoxic and carcinogenic characteristics. Due to these characteristics, its concentration in stone-fruit spirits has to be minimized. To identify factors being relevant to the formation of ethyl carbamate, questionnaires have been filled in at sampling in small distilleries in Bade...<br/><br/>A Weltring, M Rupp, U Arzberger, L Rothenbucher, H Koch, C Sproll, D W Lachenmeier (2006) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 102: 3 97-101<br/>

http://publicationslist.org/Lachenmeier/refid64 2008-05-09T12:34:02Z

High-resolution nuclear magnetic resonance ( NMR) spectroscopy is introduced for the quality control and authenticity assessment of beer in official food control. Measurements were performed using a 400-MHz NMR spectrometer using flow injection technology for automatic sample changing. Only degassing and addition of buffer ( pH 5.6 in D2O for locking and 0.1% TSP for referencing) is required to pr...<br/><br/>D W Lachenmeier, W Frank, E Humpfer, H Schafer, S Keller, M Mortter, M Spraul (2005) <i>EUROPEAN FOOD RESEARCH AND TECHNOLOGY</i> 220: 2 215-221<br/>

http://publicationslist.org/Lachenmeier/refid18 2007-10-05T15:24:22Z

Principal component analysis (PCA) was applied to the chromatographic and spectroscopic data of authentic Mexican tequilas (n = 14) and commercially available samples purchased in Mexico and Germany (n = 24). The scores scatter plot of the first two principal components (PC) of the anions chloride, nitrate, sulfate, acetate, and oxalate accounting for 78% of the variability allowed a classificatio...<br/><br/>Dirk W Lachenmeier, Elke Richling, Mercedes G López, Willi Frank, Peter Schreier (2005) <i>J Agric Food Chem</i> <i></i> <i></i> 53: 6 2151-2157<br/>

http://publicationslist.org/Lachenmeier/refid16 2007-10-05T15:24:22Z

Ethyl carbamate (EC, urethane, C2H5OCONH2) is a known genotoxic carcinogen of widespread occurrence in fermented food and beverages with the highest concentrations being found in stone-fruit spirits. Time-consuming procedures requiring extraction and gas chromatographic-mass spectrometric determination are regarded as reference procedures for the analysis of EC in alcoholic beverages. In this stud...<br/><br/>Dirk W Lachenmeier (2005) <i>Anal Bioanal Chem</i> <i></i> <i></i> 382: 6 1407-1412<br/>

http://publicationslist.org/Lachenmeier/refid15 2007-10-05T15:24:22Z

Ethyl carbamate (urethane, C(2)H(5)OCONH(2)) is a known genotoxic carcinogen of widespread occurrence in fermented food and beverages with highest concentrations found in stone-fruit spirits. Between 1986 and 2004, 631 cherry, plum or mirabelle (yellow plum) spirits were analysed for ethyl carbamate using gas chromatography in combination with mass spectrometry after extrelut extraction. The ethyl...<br/><br/>Dirk W Lachenmeier, Beatus Schehl, Thomas Kuballa, Willi Frank, Thomas Senn (2005) <i>Food Addit Contam</i> <i></i> <i></i> 22: 5 397-405<br/>

http://publicationslist.org/Lachenmeier/refid14 2007-10-05T15:24:22Z

Beside morphological signs of hypertonic dehydration as tinting of skin, sunken eyes, dry surface of the galea or dry cutting areas of organs, a chemical profile of vitreous humor was proposed as a diagnostic tool for the diagnosis of hypertonic dehydration. The profile consists of an elevation of sodium >155 mmol/l, chloride >135 mmol/l and urea >40 mg/dl. This profile was named dehydration patte...<br/><br/>Burkhard Madea, Dirk W Lachenmeier (2005) <i>Forensic Sci Int</i> <i></i> <i></i> 155: 1 1-6<br/>

http://publicationslist.org/Lachenmeier/refid118 2010-10-31T08:53:53Z

To evaluate the influence of stone content on spirit quality from stone fruit, cherry and plum mashes were prepared and fermented with a commercial and a diploid laboratory yeast strain. Fermentation parameters such as sugar content and ethanol production were followed. Despite an initial lag phase in cherry spirits, both yeast strains performed similarly, as substantiated by the determination of ...<br/><br/>Beatus Schehl, Dirk Lachenmeier, Thomas Senn, Jürgen J Heinisch (2005) <i>J Agric Food Chem</i> <i></i> <i></i> 53: 21 8230-8238<br/>

http://publicationslist.org/Lachenmeier/refid19 2007-10-05T15:24:22Z

BACKGROUND: Dopamine (DA)-derived tetrahydroisoquinolines (TIQs) are discussed as neurochemical factors of addiction processes in alcoholism. In a prospective study, the regional distribution of DA, (R)-salsolinol (SAL), and (S)-SAL, as well as norsalsolinol (NorSAL) was examined systematically in a large collective of human brain samples obtained by autopsy. METHODS: The material comprises 44 bra...<br/><br/>Frank Musshoff, Dirk W Lachenmeier, Peter Schmidt, Reinhard Dettmeyer, Burkhard Madea (2005) <i>Alcohol Clin Exp Res</i> <i></i> <i></i> 29: 1 46-52<br/>

http://publicationslist.org/Lachenmeier/refid20 2007-10-05T15:24:22Z

Gas chromatography (GC) coupled to mass spectrometry (MS) operated in selected ion monitoring (SIM) mode is currently the method of choice for the determination of the toxic contaminant ethyl carbamate in alcoholic beverages. However, even after extensive sample cleanup over diatomaceous earth columns, the identity of ethyl carbamate often cannot be ascertained with confidence, due to inconsistent...<br/><br/>Dirk W Lachenmeier, Willi Frank, Thomas Kuballa (2005) <i>Rapid Commun Mass Spectrom</i> <i></i> <i></i> 19: 2 108-112<br/>

http://publicationslist.org/Lachenmeier/refid63 2008-02-24T15:49:09Z

Absinthe is a spirit drink with a certain bitter taste, which should origin from the bitter substances of the wormwood plant (Artemisia absinthium L.). In this study, besides the principal component thujone, further characteristic components of the essential oil of wormwood are determined in absinthe and the analysis results are interpreted using multivariate statistics to authenticate the spirit ...<br/><br/>D W Lachenmeier, J Emmert, G Sartor (2005) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 101: 3 100-104<br/>

http://publicationslist.org/Lachenmeier/refid61 2008-02-24T15:32:02Z

This paper introduces a new method of determining alcoholic strength in highly viscous samples like egg liqueurs. The method relies on fully automated steam distillation in combination with oscillation-type densimetry and peristaltic pumping. The procedure is much faster (taking less than 8 min per sample) and easier than the conventional reference method (distillation, pycnometry). This makes it ...<br/><br/>D W Lachenmeier, P A Burri, T Fauser, W Frank, S G Walch (2005) <i>ANALYTICA CHIMICA ACTA</i> <i></i> <i></i> 537: 1-2 377-384<br/>

http://publicationslist.org/Lachenmeier/refid60 2008-02-24T15:48:35Z

In Commission Regulation (EC) No 2091/2002, an official reference method for the gas chromatographic determination of anethole in spirit drinks is given. For liqueurs that contain a large amount of sugars (e.g. Sambuca), a labour-intensive and time-consuming extraction procedure is required, because direct injection of the samples would contaminate the GC injection port. Therefore, in this study, ...<br/><br/>K Lachenmeier, F Musshoff, B Madea, E M Sohnius, W Frank, D W Lachenmeier (2005) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 101: 5 187-192<br/>

http://publicationslist.org/Lachenmeier/refid54 2008-02-24T15:47:07Z

A novel method combination using headspace solid-phase microextraction (HS-SPME) and gas chromatography (GC) was developed for the rapid determination of flavourings in sprit drinks. After addition of phosphate buffer (pH 7) and dicyclohexylmethanol as internal standard, the samples were thermically equilibrated (60 degrees C) and the analytes were extracted from the headspace for 5 min using SPME...<br/><br/>N Schafer, D W Lachenmeier (2005) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 101: 12 534-539<br/>

http://publicationslist.org/Lachenmeier/refid57 2008-02-24T15:48:04Z

To evade the new German fiscal legislation, issued to protect young people from the, dangers of alcohol consumption, novel instant beverages containing alcohol are recently sold. The food regulation of such alco-pops in powder form and the aspects regarding the law for the protection of the youth are discussed in this article. Besides deficiencies in the labeling and a significant deviation of the...<br/><br/>C Bauer-Christoph, D W Lachenmeier (2005) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 101: 9 389-391<br/>

http://publicationslist.org/Lachenmeier/refid68 2008-02-24T15:50:07Z

This review article provides information on all aspects of the bitter spirit, absinthe, and its major components, especially wormwood (Artemisia absinthium L.), which contains the monoterpene, thujone. In addition, the history of the alcoholic drink, from its invention in the 18th century until the recent annulment of its prohibition, is described. Historical and modern recipes are discussed in th...<br/><br/>D W Lachenmeier, W Frank, C Athanasakis, S A Padosch, B Madea, R A Rothschild, L U Kroner (2004) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 100: 4 117-129<br/>

http://publicationslist.org/Lachenmeier/refid21 2007-10-05T15:24:22Z

A fully automated procedure using alkaline hydrolysis and headspace solid-phase microextraction (HS-SPME), followed by on-fiber derivatization and gas chromatographic-mass spectrometric (GC-MS) detection has been developed for determination of cannabinoids in hemp food samples. After addition of a deuterated internal standard, the sample was hydrolyzed with sodium hydroxide and submitted to direct...<br/><br/>Dirk W Lachenmeier, Lars Kroener, Frank Musshoff, Burkhard Madea (2004) <i>Anal Bioanal Chem</i> <i></i> <i></i> 378: 1 183-189<br/>

http://publicationslist.org/Lachenmeier/refid67 2008-02-24T15:49:38Z

In 1996, the prohibition of the cultivation of plants of the species Cannabis sativa L. (so-called fibre hemp) with minor content of the psychoactive Delta(9)-tetrahydrocannabinol (THC) was lifted. Nowadays, a wide variety of hemp food products is offered on the market. As a help for evaluation of such products, this review article provides the official food control with information on all aspects...<br/><br/>D W Lachenmeier (2004) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 100: 12 481-490<br/>

http://publicationslist.org/Lachenmeier/refid69 2008-04-25T13:06:25Z

The use of ion chromatography to determine anions (chloride, nitrate, and sulphate) for the characterisation of colourless spirits, such as vodka or white rum, is presented. After evaporation to remove the volatiles, the sample was injected directly into the ion chromatograph. The assay showed good precision, never exceeding 1.6% RSD. The analytical results of 51 samples under study reveal that, i...<br/><br/>D W Lachenmeier, R Attig, W Frank, C Athanasakis (2003) <i>EUROPEAN FOOD RESEARCH AND TECHNOLOGY</i> 218: 1 105-110<br/>

http://publicationslist.org/Lachenmeier/refid22 2007-10-05T15:24:22Z

Using a solid-phase extraction procedure, an enantioselective derivatization and a gas chromatographic-mass spectrometric method, the levels of dopamine (DA) and of the dopamine-derived tetrahydroisoquinoline alkaloids (R)/(S)-salsolinol (SAL) and norsalsolinol (NorSAL) were determined in human brain samples. A complex pre-analytical synthesis of reference substances as well as deuterated internal...<br/><br/>F Musshoff, D W Lachenmeier, L Kroener, P Schmidt, R Dettmeyer, B Madea (2003) <i>Cell Mol Biol (Noisy-le-grand)</i> <i></i> <i></i> 49: 5 837-849<br/>

http://publicationslist.org/Lachenmeier/refid71 2008-02-24T15:50:51Z

This paper introduces a new method of determining ethanol in spirit drinks. The method relies on fully automated steam distillation in combination with densitometry. The procedure is much faster (taking less than 5 minutes per sample) and easier than the conventional reference method (distillation, pycnometry). This makes it possible to determine alcohol content efficiently and economically, both ...<br/><br/>D W Lachenmeier, O Sviridov, W Frank, C Athanasakis (2003) <i>DEUTSCHE LEBENSMITTEL-RUNDSCHAU</i> 99: 11 439-444<br/>

http://publicationslist.org/Lachenmeier/refid24 2007-10-05T15:24:22Z

This article describes a fully automated procedure for detecting cannabinoids in human hair samples. The procedure uses alkaline hydrolysis and headspace solid-phase dynamic extraction (HS-SPDE), followed by on-coating derivatization and gas chromatography-mass spectrometry (GC-MS). SPDE is a further development of solid-phase microextraction (SPME), based on an inside needle capillary absorption ...<br/><br/>Frank Musshoff, Dirk W Lachenmeier, Lars Kroener, Burkhard Madea (2003) <i>Forensic Sci Int</i> <i></i> <i></i> 133: 1-2 32-38<br/>

http://publicationslist.org/Lachenmeier/refid23 2007-10-05T15:24:22Z

In Germany, the substitution of methadone for heroin abusers has arisen recently and has resulted in various medicolegal problems. Normally, these concern methadone-associated deaths, or the prescription of methadone resulting in criminal prosecutions concerning physicians. Not to be forgotten is the problem of driving while taking methadone.In the years 1997-2001, we detected methadone in the blo...<br/><br/>Frank Musshoff, Dirk W Lachenmeier, Burkhard Madea (2003) <i>Forensic Sci Int</i> <i></i> <i></i> 133: 1-2 118-124<br/>

http://publicationslist.org/Lachenmeier/refid25 2007-10-05T15:24:22Z

A new method combination, headspace solid-phase dynamic extraction coupled with gas chromatography/tandem mass spectrometry (HS-SPDE/GC/MS/MS), is introduced to determine drugs of abuse in hair samples. This highly automated procedure utilizes SPDE for pre-concentration and on-coating derivatization as well as GC and triple quadrupole MS/MS for selective and sensitive detection. All these steps, a...<br/><br/>Dirk W Lachenmeier, Lars Kroener, Frank Musshoff, Burkhard Madea (2003) <i>Rapid Commun Mass Spectrom</i> <i></i> <i></i> 17: 5 472-478<br/>

http://publicationslist.org/Lachenmeier/refid28 2007-10-05T15:24:22Z

The technique of automated headspace solid-phase dynamic extraction (SPDE) coupled with gas chromatography-mass spectrometry was evaluated for the determination of amphetamines and synthetic designer drugs in hair samples. Headspace SPDE is a novel method for the solventless extraction of organic compounds in aqueous samples. In a so-called inside needle capillary absorption trap a hollow needle w...<br/><br/>Frank Musshoff, Dirk W Lachenmeier, Lars Kroener, Burkhard Madea (2002) <i>J Chromatogr A</i> <i></i> <i></i> 958: 1-2 231-238<br/>

http://publicationslist.org/Lachenmeier/refid26 2007-10-05T15:24:22Z

This paper describes a fully automated procedure using alkaline hydrolysis and headspace solid-phase microextraction (HS-SPME) followed by on-fiber derivatization and gas chromatographic-mass spectrometric (GC-MS) detection of cannabinoids in human hair samples. Ten milligrams of hair was washed with deionized water, petroleum ether, and dichloromethane. After the addition of deuterated internal s...<br/><br/>Frank Musshoff, Heike P Junker, Dirk W Lachenmeier, Lars Kroener, Burkhard Madea (2002) <i>J Anal Toxicol</i> <i></i> <i></i> 26: 8 554-560<br/>

http://publicationslist.org/Lachenmeier/refid27 2007-10-05T15:24:22Z

This study describes a fully automated procedure using alkaline hydrolysis and headspace (HS) solid-phase microextraction (SPME) followed by on-fiber derivatization and gas chromatographic (GC)-mass spectrometric (MS) detection of amphetamine, methamphetamine, methylendioxyamphetamine, methylendioxymethamphetamine, methylendioxyethylamphetamine, methylendioxyphenylbutanamine, and methylmethylendio...<br/><br/>Frank Musshoff, Heike P Junker, Dirk W Lachenmeier, Lars Kroener, Burkhard Madea (2002) <i>J Chromatogr Sci</i> <i></i> <i></i> 40: 6 359-364<br/>