http://publicationslist.org/data/Mallikarjuna.gu/atom.xml Mallikarjuna Guhttp://publicationslist.org/Mallikarjuna.gu$basepathfavicon.icoRecent additions to Mallikarjuna Gu's PublicationsList.org pagehttp://publicationslist.org/publications.png2010-06-22T14:19:02Z http://publicationslist.org/Mallikarjuna.gu/refid1 2010-06-22T14:18:36Z

Effective medical treatment and preventive measures for chemical warfare agent sulfur mustard (HD)-caused incapacitating skin toxicity are lacking, because of limited knowledge of its mechanism of action. The proliferating basal epidermal cells are primary major sites of attack during HD-caused skin injury. Therefore, employing mouse JB6 and human HaCaT epidermal cells, here, we investigated the m...<br/><br/>Neera Tewari-Singh, Mallikarjuna Gu, Chapla Agarwal, Carl W White, Rajesh Agarwal (2010) <i>Chem Res Toxicol</i> <i></i> <i></i> 23: 6 1034-1044<br/>

http://publicationslist.org/Mallikarjuna.gu/refid4 2010-06-22T14:18:36Z

Constitutively active mitogenic and prosurvival signaling cascades due to aberrant expression and interaction of growth factors and their receptors are well documented in human prostate cancer (PCa). Epidermal growth factor (EGF) and insulin-like growth factor-1 (IGF-1) are potent mitogens that regulate proliferation and survival of PCa cells via autocrine and paracrine loops involving both mitoge...<br/><br/>Mallikarjuna Gu, Komal Raina, Chapla Agarwal, Rajesh Agarwal (2010) <i>Mol Carcinog</i> <i></i> <i></i> 49: 1 1-12<br/>

http://publicationslist.org/Mallikarjuna.gu/refid6 2010-06-22T14:18:36Z

Sulfur mustard (HD) is an alkylating and cytotoxic chemical warfare agent, which inflicts severe skin toxicity and an inflammatory response. Effective medical countermeasures against HD-caused skin toxicity are lacking due to limited knowledge of related mechanisms, which is mainly attributed to the requirement of more applicable and efficient animal skin toxicity models. Using a less toxic analog...<br/><br/>Neera Tewari-Singh, Sumeet Rana, Mallikarjuna Gu, Arttatrana Pal, David J Orlicky, Carl W White, Rajesh Agarwal (2009) <i>Toxicol Sci</i> <i></i> <i></i> 108: 1 194-206<br/>

http://publicationslist.org/Mallikarjuna.gu/refid2 2010-06-22T14:18:36Z

Constitutive activation of phosphoinositide 3-kinase (PI3K)-Akt pathway transmits growth-regulatory signals that play a central role in promoting survival, proliferation, and angiogenesis in human prostate cancer cells. Here, we assessed the efficacy of inositol hexaphosphate (IP6) against invasive human prostate cancer PC-3 and C4-2B cells and regulation of PI3K-Akt pathway. IP6 treatment of cell...<br/><br/>Mallikarjuna Gu, Srirupa Roy, Komal Raina, Chapla Agarwal, Rajesh Agarwal (2009) <i>Cancer Res</i> <i></i> <i></i> 69: 24 9465-9472<br/>

http://publicationslist.org/Mallikarjuna.gu/refid5 2010-06-22T14:18:36Z

Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53. However, whether cyclin-dependent kinase inhibitor I induction by IP6 plays any role in its antitumor efficacy is unknown. Herein, we observed that either p21 or p27 knockdown by small interfering RN...<br/><br/>Srirupa Roy, Mallikarjuna Gu, Kumaraguruparan Ramasamy, Rana P Singh, Chapla Agarwal, Sunitha Siriwardana, Robert A Sclafani, Rajesh Agarwal (2009) <i>Cancer Res</i> <i></i> <i></i> 69: 3 1166-1173<br/>

http://publicationslist.org/Mallikarjuna.gu/refid3 2010-06-22T14:18:36Z

A monofunctional analog of the chemical warfare agent sulfur mustard (HD), 2-chloroethyl ethyl sulfide (CEES), induces tissue damage similar to HD. Herein we studied the molecular mechanisms associated with CEES-induced skin inflammation and toxicity in SKH-1 hairless mice. Topical CEES exposure caused an increase in oxidative stress as observed by enhanced 4-hydroxynonenal and 5,5-dimethyl-2-(8-o...<br/><br/>Arttatrana Pal, Neera Tewari-Singh, Mallikarjuna Gu, Chapla Agarwal, Jie Huang, Brian J Day, Carl W White, Rajesh Agarwal (2009) <i>Free Radic Biol Med</i> <i></i> <i></i> 47: 11 1640-1651<br/>

http://publicationslist.org/Mallikarjuna.gu/refid8 2010-06-22T14:18:36Z

UVB exposure of skin results in various biologic responses either through direct or indirect damage to DNA and non-DNA cellular targets via the formation of free radicals, reactive oxygen species (ROS) and inflammation. Bucillamine [N-(2-mercapto-2-methylpropionyl)-l-cysteine] is a cysteine-derived compound that can replenish endogenous glutathione due to its two donatable thiol groups, and functi...<br/><br/>Adil Anwar, Mallikarjuna Gu, Sara Brady, Lubna Qamar, Kian Behbakht, Yiqun G Shellman, Rajesh Agarwal, David A Norris, Lawrence D Horwitz, Mayumi Fujita (2008) <i>Photochem Photobiol</i> <i></i> <i></i> 84: 2 477-483<br/>

http://publicationslist.org/Mallikarjuna.gu/refid7 2010-06-22T14:18:36Z

Herein, for the first time, we investigated in vivo efficacy and associated molecular biomarkers and mechanisms of a chemopreventive agent, silibinin, against human colorectal carcinoma (CRC) HT29 xenograft growth. Nude mice were implanted with HT29 cells and fed with vehicle (carboxymethyl cellulose or phosphatidylcholine) or 200 mg/kg/d dose of silibinin or 100 and 200 mg/kg/d doses of silybin-p...<br/><br/>Rana P Singh, Mallikarjuna Gu, Rajesh Agarwal (2008) <i>Cancer Res</i> <i></i> <i></i> 68: 6 2043-2050<br/>

http://publicationslist.org/Mallikarjuna.gu/refid9 2010-06-22T14:18:36Z

Effective strategies are lacking for the management of urinary bladder cancer for which smoking is a potential risk factor. Herein, we evaluated chemoprevention of urinary bladder cancer by natural chemopreventive agents, silymarin and silibinin, in a preclinical animal (ICR mouse) model of bladder cancer induced by tobacco smoke carcinogen N-butyl-N-(4-hydroxybutyl) nitrosamine (OH-BBN). Mice wer...<br/><br/>Alpna Tyagi, Komal Raina, Rana P Singh, Mallikarjuna Gu, Chapla Agarwal, Gail Harrison, L Michael Glode, Rajesh Agarwal (2007) <i>Mol Cancer Ther</i> <i></i> <i></i> 6: 12 Pt 1 3248-3255<br/>

http://publicationslist.org/Mallikarjuna.gu/refid10 2010-06-22T14:18:36Z

Sunscreens partially filter UVB and, therefore, could partially prevent skin cancer; however, efficient approaches are desired to effectively prevent photocarcinogenesis. It is hypothesized that nontoxic pharmacologically active natural compounds can increase photoprotective effects. Our completed studies suggest that silibinin, a bioactive phytochemical, strongly prevents photocarcinogenesis; how...<br/><br/>Mallikarjuna Gu, Rana P Singh, Sivanandhan Dhanalakshmi, Chapla Agarwal, Rajesh Agarwal (2007) <i>Cancer Res</i> <i></i> <i></i> 67: 7 3483-3491<br/>

http://publicationslist.org/Mallikarjuna.gu/refid11 2010-06-22T14:18:36Z

PURPOSE: Accumulating evidences suggest the beneficial effects of fruit-and-vegetable consumption in lowering the risk of various cancers, including colorectal cancer. Herein, we investigated the in vitro and in vivo anticancer effects and associated mechanisms of grape seed extract (GSE), a rich source of proanthocyanidins, against colorectal cancer. EXPERIMENTAL DESIGN: Effects of GSE were exami...<br/><br/>Manjinder Kaur, Rana P Singh, Mallikarjuna Gu, Rajesh Agarwal, Chapla Agarwal (2006) <i>Clin Cancer Res</i> <i></i> <i></i> 12: 20 Pt 1 6194-6202<br/>

http://publicationslist.org/Mallikarjuna.gu/refid12 2010-06-22T14:18:36Z

UVB radiation-induced DNA damage in skin activates cellular pathways involved in DNA repair, cell cycle regulation, and apoptosis, important events that prevent conversion of damaged skin cells into cancer. We reported recently the efficacy of silibinin against photocarcinogenesis along with altered molecular events in tumors (Cancer Research, 64:6349-56, 2004). The molecular and biological events...<br/><br/>Mallikarjuna Gu, Rana P Singh, Sivanandhan Dhanalakshmi, Sarumathi Mohan, Rajesh Agarwal (2006) <i>Mol Cancer Ther</i> <i></i> <i></i> 5: 8 2121-2129<br/>

http://publicationslist.org/Mallikarjuna.gu/refid14 2010-06-22T14:18:36Z

Ultraviolet B (UVB) radiation is a complete skin carcinogen causing DNA damage as a tumor-initiating event and activating signaling cascades that play a critical role in its tumor-promoting potential. Recently we reported that a naturally occurring flavonoid, silibinin, protects UVB-induced skin damages and prevents photocarcinogenesis. Here we examined silibinin efficacy on acute and chronic UVB-...<br/><br/>Mallikarjuna Gu, Sivanandhan Dhanalakshmi, Sarumathi Mohan, Rana P Singh, Rajesh Agarwal (2005) <i>Carcinogenesis</i> <i></i> <i></i> 26: 8 1404-1413<br/>

http://publicationslist.org/Mallikarjuna.gu/refid13 2010-06-22T14:18:36Z

Solar radiation is the causal etiologic factor in the development of nonmelanoma skin cancer (NMSC). Depletion of the stratospheric ozone layer leads to an increase in ambient UV radiation loads, which are expected to further raise skin cancer incidence in many temperate parts of the world, including the United States, suggesting that skin cancer chemopreventive approaches via biomarker efficacy s...<br/><br/>Mallikarjuna Gu, Sivanandhan Dhanalakshmi, Rana P Singh, Rajesh Agarwal (2005) <i>Cancer Epidemiol Biomarkers Prev</i> <i></i> <i></i> 14: 5 1344-1349<br/>

http://publicationslist.org/Mallikarjuna.gu/refid19 2010-06-22T14:18:36Z

PURPOSE: Diet composition is an important etiologic factor in prostate cancer (PCA) growth and has significant impact on clinical PCA appearance. Because inositol hexaphosphate (IP6) is a dietary phytochemical present in cereals, soy, legumes, and fiber-rich foods, we evaluated efficacy of IP6 against PCA growth and associated molecular events. EXPERIMENTAL DESIGN: DU145 cells were injected into n...<br/><br/>Rana P Singh, Girish Sharma, G U Mallikarjuna, Sivanandhan Dhanalakshmi, Chapla Agarwal, Rajesh Agarwal (2004) <i>Clin Cancer Res</i> <i></i> <i></i> 10: 1 Pt 1 244-250<br/>

http://publicationslist.org/Mallikarjuna.gu/refid20 2010-06-22T14:18:36Z

An increasing incidence of human skin cancer and other adverse effects of solar ultraviolet (UV) radiation enhance the need for novel chemoprevention strategies. Here, we have studied the effect of silibinin on UVB-induced apoptosis in HaCaT cells. Silibinin strongly prevented lower doses (15 and 30 mJ/cm2) of UVB-induced apoptosis, as observed by a reversal in UVB-caused poly(ADP-ribose) polymera...<br/><br/>Sivanandhan Dhanalakshmi, G U Mallikarjuna, Rana P Singh, Rajesh Agarwal (2004) <i>Carcinogenesis</i> <i></i> <i></i> 25: 1 99-106<br/>

http://publicationslist.org/Mallikarjuna.gu/refid18 2010-06-22T14:18:36Z

Non-melanoma skin cancer (NMSC) accounts for >1 million new cases each year in the US alone suggesting that more approaches are needed for its prevention and control. Earlier studies by us have shown that silymarin (a crude form of biologically active silibinin with some other isomers), isolated from milk thistle, affords strong protection against ultraviolet (UV) radiation-induced NMSC in SKH-1 h...<br/><br/>Sivanandhan Dhanalakshmi, G U Mallikarjuna, Rana P Singh, Rajesh Agarwal (2004) <i>Carcinogenesis</i> <i></i> <i></i> 25: 8 1459-1465<br/>

http://publicationslist.org/Mallikarjuna.gu/refid15 2010-06-22T14:18:36Z

The acute and cumulative dose-related toxicity and drug resistance, mediated via nuclear factor kappaB (NFkappaB), of anthracycline anticancer drugs pose a major problem in cancer chemotherapy. Here, we report that oral silibinin (a flavanone) suppresses human non-small-cell lung carcinoma A549 xenograft growth (P = 0.003) and enhances the therapeutic response (P < 0.05) of doxorubicin in athymic ...<br/><br/>Rana P Singh, G U Mallikarjuna, Girish Sharma, Sivanandhan Dhanalakshmi, Anil K Tyagi, Daniel C F Chan, Chapla Agarwal, Rajesh Agarwal (2004) <i>Clin Cancer Res</i> <i></i> <i></i> 10: 24 8641-8647<br/>

http://publicationslist.org/Mallikarjuna.gu/refid17 2010-06-22T14:18:36Z

Several recent studies by us have shown the strong chemopreventive efficacy of silibinin against both ultraviolet B (UVB) radiation and chemical carcinogen-induced tumorigenesis in mouse skin models. The molecular mechanisms underlying silibinin protective efficacy, however, are not completely known. Here, we examined the effect of silibinin on UVB-caused apoptosis in human epidermoid carcinoma A4...<br/><br/>Sarumathi Mohan, Sivanandhan Dhanalakshmi, G U Mallikarjuna, Rana P Singh, Rajesh Agarwal (2004) <i>Biochem Biophys Res Commun</i> <i></i> <i></i> 320: 1 183-189<br/>

http://publicationslist.org/Mallikarjuna.gu/refid16 2010-06-22T14:18:36Z

Here, we assessed the protective effect of silibinin on UVB-induced skin carcinogenesis in SKH-1 hairless mice. Topical application of silibinin before or immediately after UVB exposure or its dietary feeding resulted in a strong protection against photocarcinogenesis, in terms of tumor multiplicity (60-66%; P < 0.001), tumor volume per mouse (93-97%; P < 0.001) and tumor volume per tumor (80-91%;...<br/><br/>Gu Mallikarjuna, Sivanandhan Dhanalakshmi, Rana P Singh, Chapla Agarwal, Rajesh Agarwal (2004) <i>Cancer Res</i> <i></i> <i></i> 64: 17 6349-6356<br/>

http://publicationslist.org/Mallikarjuna.gu/refid21 2010-06-22T14:18:36Z

The present study was conducted to ascertain the modulatory influences of Ferula asafoetida L. (asafoetida, flavoring agent) on the mammary epithelial tissue differentiation, hepatic drug metabolizing enzymes, antioxidant profiles and N-methyl-N-nitrosourea (MNU)-induced mammary carcinogenesis in Sprague-Dawley rats. Feeding with two doses of asafoetida (1.25 and 2.5% w/w in diet) showed a remarka...<br/><br/>G U Mallikarjuna, S Dhanalakshmi, S Raisuddin, A Ramesha Rao (2003) <i>Breast Cancer Res Treat</i> <i></i> <i></i> 81: 1 1-10<br/>