http://publicationslist.org/data/SC.Cheong/atom.xml Siew Chiat Cheonghttp://publicationslist.org/SC.Cheong$basepathfavicon.icoRecent additions to Siew Chiat Cheong's PublicationsList.org pagehttp://publicationslist.org/publications.png2011-11-25T08:57:03Z http://publicationslist.org/SC.Cheong/refid9 2011-11-25T08:51:30Z

Inositol Inpp5k (or Pps, SKIP) is a member of the inositol polyphosphate 5-phosphatases family with a poorly characterized function in vivo. In this study, we explored the function of this inositol 5-phosphatase in mice and cells overexpressing the 42-kDa mouse Inpp5k protein. Inpp5k transgenic mice present defects in water metabolism characterized by a reduced plasma osmolality at baseline, a del...<br/><br/>Pernot E, Terryn S, Cheong SC, Markadieu N, Janas S, Blockmans M, Jacoby M, Pouillon V, Gayral S, Rossier BC, Beauwens R, Erneux C, Devuyst O, Schurmans S. (2011) <i>Pflugers Arch</i> 462: 6 871-83<br/>

http://publicationslist.org/SC.Cheong/refid5 2010-02-03T19:30:03Z

The majority of clinical trials evaluating replication-selective oncolytic adenoviruses utilized mutants with immunomodulatory E3B genes deleted, likely contributing to the attenuated efficacy. We investigated whether an intact immune response could contribute to the observed improved efficacy in response to combinations with chemotherapeutics. Seven carcinoma cell lines were evaluated by combinin...<br/><br/>S C Cheong, Y Wang, J-H Meng, R Hill, K Sweeney, D Kirn, N R Lemoine, G Halldén (2008) <i>Cancer Gene Ther</i> <i></i> <i></i> 15: 1 40-50<br/>

http://publicationslist.org/SC.Cheong/refid6 2010-02-03T19:30:03Z

BACKGROUND: Hybrids obtained by fusion between tumour cells (TC) and dendritic cells (DC) have been proposed as anti-tumour vaccines because of their potential to combine the expression of tumour-associated antigens with efficient antigen presentation. The classical methods used for fusion, polyethylene glycol (PEG) and electrofusion, are cytotoxic and generate cell debris that can be taken up by ...<br/><br/>Siew Chiat Cheong, Isabelle Blangenois, Jean-Denis Franssen, Charlotte Servais, Vy Phan, Myrto Trakatelli, Catherine Bruyns, Richard Vile, Thierry Velu, Annick Brandenburger (2006) <i>J Gene Med</i> <i></i> <i></i> 8: 7 919-928<br/>

http://publicationslist.org/SC.Cheong/refid1 2010-02-03T19:29:25Z

BACKGROUND: The natural oncotropism and oncotoxicity of vectors derived from the autonomous parvovirus, minute virus of mice (prototype strain) [MVM(p)], combined with the immunotherapeutic properties of cytokine transgenes, make them interesting candidates for cancer gene therapy. METHODS: The in vivo anti-tumour activity of a recombinant parvoviral vector, MVM-IL2, was evaluated in a syngeneic m...<br/><br/>Karim El Bakkouri, Charlotte Servais, Nathalie Clément, Siew Chiat Cheong, Jean-Denis Franssen, Thierry Velu, Annick Brandenburger (2005) <i>J Gene Med</i> <i></i> <i></i> 7: 2 189-197<br/>

http://publicationslist.org/SC.Cheong/refid2 2010-02-03T19:29:25Z

Fusion of tumor cells with antigen-presenting cells (APCs) has been proposed for the preparation of cancer vaccines. However, generation of these hybrids, using physical or chemical methods such as electrofusion or polyethylene glycol (PEG), has been difficult to standardize. Characterization of cell fusion has also been problematic because of difficulties in differentiating fusion from cell aggre...<br/><br/>Vy Phan, Fiona Errington, S Chiat Cheong, Tim Kottke, Michael Gough, Sharon Altmann, Annick Brandenburger, Steve Emery, Scott Strome, Andrew Bateman, Bernard Bonnotte, Alan Melcher, Richard Vile (2003) <i>Nat Med</i> <i></i> <i></i> 9: 9 1215-1219<br/>

http://publicationslist.org/SC.Cheong/refid3 2011-11-25T08:42:28Z

The development of vectors for gene therapy requires the definition of quality control parameters such as titration, contamination, transduction efficiency and biological effects in defined model systems. For most viral vectors, the classical titration by plaque formation is not applicable, because vectors are defective for replication and packaging cell lines are not always available. In particul...<br/><br/>Siew Chiat Cheong, Nathalie Clément, Thierry Velu, Annick Brandenburger (2003) <i>J Virol Methods</i> <i></i> <i></i> 109: 2 119-124<br/>

http://publicationslist.org/SC.Cheong/refid7 2010-02-03T19:31:06Z

The objective of the present study was to evaluate the antitumor effect of a defective adenovirus expressing a secretable angiostatin-like molecule (AdK3) in combination with radiotherapy in rat C6 gliomas s.c. preestablished into athymic mice. In vitro, the combination regimen was significantly (P < 0.001) more cytotoxic for human microcapillary endothelial cells than either treatment alone, wher...<br/><br/>F Griscelli, H Li, C Cheong, P Opolon, A Bennaceur-Griscelli, G Vassal, J Soria, C Soria, H Lu, M Perricaudet, P Yeh (2000) <i>Proc Natl Acad Sci U S A</i> 97: 12 6698-6703<br/>

http://publicationslist.org/SC.Cheong/refid4 2010-02-03T19:29:25Z

Recombinant adenovirus vectors are popular tools for gene transfer and gene therapy. However biosafety constraints require that all handling of the vectors and vector-containing samples is restricted to dedicated containment laboratories, unless they had undergone a validated virus-inactivation procedure, which decontaminates the samples from any active virus. In this study we evaluated the feasib...<br/><br/>F H Schagen, A C Moor, S C Cheong, S J Cramer, H van Ormondt, A J van der Eb, T M Dubbelman, R C Hoeben (1999) <i>Gene Ther</i> <i></i> <i></i> 6: 5 873-881<br/>

http://publicationslist.org/SC.Cheong/refid8 2010-02-03T19:32:04Z

S J Gobin, V Keijsers, C Cheong, M van Zutphen, P J Van den Elsen (1999) <i>Transplant Proc</i> 31: 4 1857-1859<br/>