http://publicationslist.org/data/a.ganci/atom.xml Antonella Gancihttp://publicationslist.org/a.ganci$basepathfavicon.icoRecent additions to Antonella Ganci's PublicationsList.org pagehttp://publicationslist.org/publications.png2010-01-27T14:35:13Z http://publicationslist.org/a.ganci/refid1 2010-01-25T13:26:03Z

Summary Background: Chronic hyperglycemia is a major contributor to in vivo platelet activation in diabetes mellitus. Objectives: We aimed at evaluating the effects of acarbose, an alpha-glucosidase inhibitor, on platelet activation and its determinants in newly-diagnosed type 2 diabetic patients. Methods: Forty-eight subjects (26 M, aged 61+/-8 yr) with early type 2 diabetes (baseline HbA(1c)</= ...<br/><br/>F Santilli, G Formoso, P Sbraccia, M Averna, R Miccoli, P Di Fulvio, A Ganci, N Pulizzi, S Lattanzio, G Ciabattoni, A Consoli, R Lauro, C Patrono, G Davì (2010) <i>J Thromb Haemost</i> <i></i> <i></i> : <br/>

http://publicationslist.org/a.ganci/refid2 2010-01-25T13:26:03Z

Relapses of hyperthyroidism after treatment with radioiodine for uni- or multi-nodular goiter may be accompanied by the appearance of TSAb. However, this phenomenon has only emerged from one retrospective study on Northern European patients, in which it was not possible to determine whether TSAb also appeared in treated patients who did not relapse. The present study aimed to assess the appearance...<br/><br/>N Custro, A Ganci, V Scafidi (2003) <i>J Endocrinol Invest</i> <i></i> <i></i> 26: 2 106-110<br/>

http://publicationslist.org/a.ganci/refid3 2010-01-25T13:26:03Z

BACKGROUND: The evidence that inflammation plays a pivotal role in the pathophysiology of acute coronary syndromes prompted us to investigate the effects of glucocorticoid treatment on leukotriene (LT) C4 and thromboxane (TX) A2 biosynthesis in unstable angina. METHODS AND RESULTS: Urinary LTE4 and 11-dehydro-TXB2 were significantly higher in 12 patients with unstable angina than in 12 patients wi...<br/><br/>Francesco Cipollone, Antonina Ganci, Anita Greco, Maria Rosaria Panara, Massimo Pasquale, Domenico Di Gregorio, Ettore Porreca, Andrea Mezzetti, Franco Cuccurullo, Paola Patrignani (2003) <i>Circulation</i> <i></i> <i></i> 107: 1 55-61<br/>

http://publicationslist.org/a.ganci/refid5 2010-01-25T13:26:03Z

BACKGROUND: Despite great improvement in patient and graft survival, the long-term morbidity and mortality in renal transplant recipients (RTRs) are still significant, with a high incidence of cardiovascular disease-related deaths. METHODS: We investigated thromboxane (TXA2) biosynthesis and endothelial and coagulative activation in 65 patients who received a renal transplant. RESULTS: The rate of...<br/><br/>M Averna, C M Barbagallo, A Ganci, C Giammarresi, A B Cefalù, V Sparacino, F Caputo, S Basili, A Notarbartolo, G Davì (2001) <i>Kidney Int</i> <i></i> <i></i> 59: 4 1574-1579<br/>

http://publicationslist.org/a.ganci/refid4 2010-01-25T13:26:03Z

OBJECTIVES: This study aimed at investigating the respective impacts of virus-related chronic hepatitis (CH) and liver cirrhosis (LC) on glycemic homeostasis, with reference to grading and/or staging of liver disease and to contribution of the two main responsible viruses. MATERIAL AND METHODS: The glycometabolic features of 82 patients with CH (B-related 16, and C-related 66) and 145 with LC (B-r...<br/><br/>N Custro, A Carroccio, A Ganci, V Scafidi, P Campagna, L Di Prima, G Montalto (2001) <i>Diabetes Metab</i> <i></i> <i></i> 27: 4 Pt 1 476-481<br/>

http://publicationslist.org/a.ganci/refid6 2010-01-25T13:26:03Z

F(2)-isoprostanes are bioactive peroxidation products of arachidonic acid whose urinary excretion provides an index of lipid peroxidation in vivo. We tested the hypothesis that formation of F(2)-isoprostanes is altered in patients with cystic fibrosis and contributes to platelet activation and pulmonary dysfunction in this setting. The urinary excretion of immunoreactive 8-iso-prostaglandin F(2alp...<br/><br/>G Ciabattoni, G Davì, M Collura, L Iapichino, F Pardo, A Ganci, R Romagnoli, J Maclouf, C Patrono (2000) <i>Am J Respir Crit Care Med</i> <i></i> <i></i> 162: 4 Pt 1 1195-1201<br/>

http://publicationslist.org/a.ganci/refid7 2010-01-25T13:26:03Z

Thromboxane (Tx) A2 biosynthesis is enhanced in the majority of patients with type IIa hypercholesterolemia. Because blood clotting activation is an important component of the inflammatory response, involved in the initiation and progression of atherosclerotic plaques, we have investigated TxA2 biosynthesis, neutrophil activation and thrombin generation in 24 patients with type IIa hypercholestero...<br/><br/>G Davì, A Ganci, M Averna, C Giammarresi, C Barbagallo, I Catalano, A Calà, A Notarbartolo (1995) <i>Thromb Haemost</i> <i></i> <i></i> 74: 4 1015-1019<br/>

http://publicationslist.org/a.ganci/refid8 2010-01-25T13:27:15Z

BACKGROUND: The active metabolite of the anti-inflammatory drug nabumetone has been characterized as a selective inhibitor of the inducible prostaglandin H synthase (PGHS). The aim of this study was to investigate the rate of eicosanoid biosynthesis after oral dosing with nabumetone in nine healthy subjects. METHODS: We measured the urinary excretion of products of platelet (11-dehydro-thromboxane...<br/><br/>F Cipollone, A Ganci, M R Panara, A Greco, F Cuccurullo, C Patrono, P Patrignani (1995) <i>Clin Pharmacol Ther</i> <i></i> <i></i> 58: 3 335-341<br/>

http://publicationslist.org/a.ganci/refid12 2010-01-25T13:27:15Z

P Patrignani, M R Panara, A Greco, O Fusco, C Natoli, S Iacobelli, F Cipollone, A Ganci, C Créminon, J Maclouf (1995) <i>Adv Prostaglandin Thromboxane Leukot Res</i> <i></i> <i></i> 23: 129-131<br/>

http://publicationslist.org/a.ganci/refid10 2010-01-25T13:27:15Z

Thromboxane A2 (TXA2) biosynthesis is enhanced in the majority of patients with type IIa hypercholesterolemia. Because simvastatin (a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor) was previously shown to reduce platelet aggregation and TXB2 production ex vivo, we investigated TXA2 biosynthesis and platelet function in 24 patients with type IIa hypercholesterolemia randomized to receiv...<br/><br/>A Notarbartolo, G Davì, M Averna, C M Barbagallo, A Ganci, C Giammarresi, F P La Placa, C Patrono (1995) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 15: 2 247-251<br/>

http://publicationslist.org/a.ganci/refid11 2010-01-25T13:27:15Z

G Davì, L Iapichino, V Balsamo, A Ganci, C Giammarresi, P Patrignani, C Patrono (1995) <i>Adv Prostaglandin Thromboxane Leukot Res</i> <i></i> <i></i> 23: 369-371<br/>

http://publicationslist.org/a.ganci/refid9 2010-01-25T13:27:15Z

Endothelial injury in vivo induced by Rickettsia Conorii, the etiologic agent of Mediterranean Spotted Fever (MSF) has been recently demonstrated. We sought to determine whether platelet and/or coagulative activation in vivo can be demonstrated in the acute phase of MSF, through measurements of a major metabolite of thromboxane (TX) in the urine (11-dehydro-TXB2) and of plasma prothrombin fragment...<br/><br/>G Davì, C Giammarresi, S Vigneri, A Ganci, C Ferri, L Di Francesco, G Vitale, S Mansueto (1995) <i>Thromb Haemost</i> <i></i> <i></i> 74: 2 631-634<br/>

http://publicationslist.org/a.ganci/refid13 2010-01-25T13:27:15Z

The aim of our study was to characterize a model of human prostaglandin endoperoxide synthase-2 (PGHS-2) expression allowing the assessment of pharmacological inhibition in vitro and ex vivo. Heparinized human whole blood samples were incubated with lipopolysaccharide (LPS, 0.1-50 micrograms/ml) for 0 to 24 hr at 37 degrees C. The contribution of platelet PGHS-1 was suppressed by either pretreatin...<br/><br/>P Patrignani, M R Panara, A Greco, O Fusco, C Natoli, S Iacobelli, F Cipollone, A Ganci, C Créminon, J Maclouf (1994) <i>J Pharmacol Exp Ther</i> <i></i> <i></i> 271: 3 1705-1712<br/>

http://publicationslist.org/a.ganci/refid14 2010-01-25T13:27:15Z

Indobufen is a reversible inhibitor of platelet prostaglandin G/H-synthase. To verify the dose dependence of the antiplatelet effect of indobufen on ex vivo and in vivo indexes of thromboxane (TX) biosynthesis and TXA2-dependent platelet function, we studied nine patients with non-insulin-dependent diabetes mellitus (NIDDM). This was a randomized, double-blind, crossover study in which each patien...<br/><br/>G Davì, C Patrono, I Catalano, N Custro, C Giammarresi, A Ganci, F Cosentino, A Notarbartolo (1993) <i>Arterioscler Thromb</i> <i></i> <i></i> 13: 9 1346-1349<br/>

http://publicationslist.org/a.ganci/refid15 2010-01-25T13:27:15Z

BACKGROUND. Increased platelet thromboxane (TX)A2 production has been described in type IIa hypercholesterolemia. To verify the relevance of these capacity-related measurements to the actual rate of TXA2 biosynthesis in vivo, we studied the urinary excretion of its major enzymatic metabolites in 46 patients with type IIa hypercholesterolemia and 20 age-matched controls. METHODS AND RESULTS. Urinar...<br/><br/>G Davì, M Averna, I Catalano, C Barbagallo, A Ganci, A Notarbartolo, G Ciabattoni, C Patrono (1992) <i>Circulation</i> <i></i> <i></i> 85: 5 1792-1798<br/>