http://publicationslist.org/data/a.riutta/atom.xml Asko Riuttahttp://publicationslist.org/a.riutta$basepathfavicon.icoRecent additions to Asko Riutta's PublicationsList.org pagehttp://publicationslist.org/publications.png2009-10-01T10:39:46Z http://publicationslist.org/a.riutta/refid2 2009-10-01T09:36:33Z

BACKGROUND: Hyperuricemia may play a role in the pathogenesis of cardiovascular disease, but uric acid is also a significant antioxidant. We investigated the effects of oxonic acid-induced hyperuricemia on carotid artery tone in experimental renal insufficiency. METHODS: Three weeks after 5/6 nephrectomy (NX) or Sham operation, male Sprague-Dawley rats were allocated to 2.0% oxonic acid or control...<br/><br/>Venla Kurra, Arttu Eräranta, Pasi Jolma, Tuija I Vehmas, Asko Riutta, Eeva Moilanen, Anna Tahvanainen, Jarkko Kalliovalkama, Onni Niemelä, Juhani Myllymäki, Jukka Mustonen, Ilkka Pörsti (2009) <i>Am J Hypertens</i> <i></i> <i></i> 22: 9 964-970<br/>

http://publicationslist.org/a.riutta/refid1 2009-10-01T09:36:33Z

OBJECTIVE: To study the diurnal variation of melatonin and cortisol in critically ill patients and to assess whether the severity of organ dysfunction, sedation and sympathetic activity correlate with the production of these hormones. DESIGN: Prospective clinical study. SETTING: Surgical intensive care unit in a university hospital. PATIENTS: Forty non-septic patients without brain injury and trea...<br/><br/>Asko Riutta, Pauli Ylitalo, Seppo Kaukinen (2009) <i>Intensive Care Med</i> <i></i> <i></i> 35: 10 1720-1727<br/>

http://publicationslist.org/a.riutta/refid50 2009-10-01T10:10:35Z

RSK Takala, V-M Karjalainen, MS Salo, O Kirvelä, P Kääpä, A Riutta, R Aantaa. (2009) <i>Open Inflammatory J</i> 2: 1-8<br/>

http://publicationslist.org/a.riutta/refid3 2009-10-01T09:36:33Z

Cyclooxygenase-2 (COX-2) is expressed in rheumatoid and osteoarthritic cartilage and produces pro-inflammatory prostanoids in the joint. In the present study, we investigated the effects of disease modifying anti-rheumatic drugs on COX-2 expression in chondrocytes. Unlike the other tested drugs, aurothiomalate was found to inhibit COX-2 expression in chondrocytes. In the further studies, effects a...<br/><br/>Riina Nieminen, Katriina Vuolteenaho, Asko Riutta, Hannu Kankaanranta, Peter M van der Kraan, Teemu Moilanen, Eeva Moilanen (2008) <i>Eur J Pharmacol</i> <i></i> <i></i> 587: 1-3 309-316<br/>

http://publicationslist.org/a.riutta/refid5 2009-10-01T09:36:33Z

Bisphosphonates are antiatherosclerotic, suppress monocyte-macrophages, and modulate proinflammatory mediators. Prostaglandin (PG) E(2), thromboxane (TX) A(2), and cyclooxygenase-2 (COX-2) enzyme are involved in inflammation and atherosclerosis. We studied the effects of four bisphosphonates (etidronate, clodronate, tiludronate, and alendronate) on PGE(2) and TXB(2) production in human whole blood...<br/><br/>O-M Tuominen, R Ylitalo-Heikkala, T I Vehmas, I Mucha, P Ylitalo, A Riutta (2006) <i>Methods Find Exp Clin Pharmacol</i> <i></i> <i></i> 28: 6 361-367<br/>

http://publicationslist.org/a.riutta/refid4 2009-10-01T09:36:33Z

The metabolism of melatonin to 6-sulphatoxymelatonin (aMT6S) and N-acetylserotonin (NAS) is catalyzed by cytochrome-P450 (CYP) isozymes CYP1A2 and CYP2C19 respectively. We studied the in vivo effect of CYP2C19 substrate (citalopram, omepratzole, or lansopratzole) on the metabolism of endogenous and exogenous melatonin by measuring the excretion of urinary aMT6S, the main metabolite of melatonin, a...<br/><br/>K Huuhka, A Riutta, R Haataja, P Ylitalo, E Leinonen (2006) <i>Methods Find Exp Clin Pharmacol</i> <i></i> <i></i> 28: 7 447-450<br/>

http://publicationslist.org/a.riutta/refid6 2009-10-01T09:36:33Z

OBJECTIVE: Elevated levels of 11-dehydrothromboxane B2 (11-dehydro-TXB2) excreted in urine have been observed in acute ischemic stroke. This marker of platelet activation has not been investigated in patients with acute spontaneous intracerebral hemorrhage (ICH). METHODS: We examined 43 patients with spontaneous ICH and 23 controls. Urinary excretion rates of 11-dehydro-TXB2, 2,3-dinor-thromboxane...<br/><br/>Pertti Saloheimo, Seppo Juvela, Asko Riutta, Juhani Pyhtinen, Matti Hillbom (2005) <i>Thromb Res</i> <i></i> <i></i> 115: 5 367-373<br/>

http://publicationslist.org/a.riutta/refid55 2009-10-01T10:35:38Z

M Vainio, A Riutta, AM Koivisto, J Mäenpää (2005) <i>Obstet Gynecol Surv</i> 60: 281-282<br/>

http://publicationslist.org/a.riutta/refid7 2009-10-01T09:36:33Z

BACKGROUND: The aim of this study was to investigate the prostanoid production in pregnancies at high risk for hypertensive disorders, and the effect of low-dose acetylsalicylic acid (ASA) on prostanoids. MATERIAL AND METHODS: Ninety women with a bilateral notching in uterine arteries screened by Doppler ultrasound at 12-14 gestational weeks were randomized to the ASA (0.5 mg/kg/day) or placebo gr...<br/><br/>Merja Vainio, Asko Riutta, Anna-Maija Koivisto, Johanna Mäenpää (2004) <i>Acta Obstet Gynecol Scand</i> <i></i> <i></i> 83: 12 1119-1123<br/>

http://publicationslist.org/a.riutta/refid9 2009-10-01T09:36:33Z

BACKGROUND: Volatile anaesthetics have been shown to affect the release of pulmonary inflammatory mediators and exacerbate pulmonary injury after experimental aspiration. Thus, in theory, volatile anaesthetics may worsen inflammatory pulmonary injury and disease. We have previously described that no significant changes in alveolar ultrastructure are seen after sevoflurane anaesthesia. However, thi...<br/><br/>R S K Takala, H R Soukka, M S Salo, O A Kirvelä, P O Kääpä, A A Rajamäki, A Riutta, R E Aantaa (2004) <i>Acta Anaesthesiol Scand</i> <i></i> <i></i> 48: 1 40-45<br/>

http://publicationslist.org/a.riutta/refid8 2009-10-01T09:36:33Z

8-Isoprostaglandin F2alpha is one of a series of isoprostanes formed by free radical catalysed peroxidation of arachidonic acid. Urinary 8-isoprostaglandin F2alpha is a new marker which reflects oxidative stress in vivo and can be utilized as a diagnostic tool to assess the extent of oxidative stress in various disease states associated with lipid peroxidation. Increased levels of 8-isoprostagland...<br/><br/>P Rossi, A Riutta, P Kuukasjärvi, T Vehmas, I Mucha, J P Salenius (2004) <i>Prostaglandins Leukot Essent Fatty Acids</i> <i></i> <i></i> 71: 2 97-101<br/>

http://publicationslist.org/a.riutta/refid11 2009-10-01T09:36:33Z

Our purpose was to determine urinary 9 alpha,11 beta-prostaglandin F2, the primary metabolite of prostaglandin D2, in pregnancies at high risk for hypertensive disorders and the effect of acetylsalicylic acid on 9 alpha,11 beta-prostaglandin F2. Ninety high risk women were randomised to acetylsalicylic acid and placebo groups at 12-14 weeks of gestation, with 43 women in both groups followed up su...<br/><br/>Merja Vainio, Asko Riutta, Anna-Maija Koivisto, Johanna Mäenpää (2003) <i>Prostaglandins Leukot Essent Fatty Acids</i> <i></i> <i></i> 69: 1 79-83<br/>

http://publicationslist.org/a.riutta/refid10 2009-10-01T09:36:33Z

The effects of chronic nitric oxide deficiency on prostacyclin and thromboxane A(2) production in vivo are unknown. Therefore, we treated rats with N(G)-nitro-L-arginine methyl ester (L-NAME), and used losartan and high calcium diet as antihypertensive treatments. Forty eight Wistar rats were divided into six groups: control; losartan (20mgkg(-1)day(-1)); high calcium diet (dietary calcium elevate...<br/><br/>Juha Alanko, Pasi Jolma, Peeter Kööbi, Asko Riutta, Jarkko Kalliovalkama, Jari Petteri Tolvanen, Ilkka Pörsti (2003) <i>Prostaglandins Leukot Essent Fatty Acids</i> <i></i> <i></i> 69: 5 345-350<br/>

http://publicationslist.org/a.riutta/refid12 2009-10-01T09:36:33Z

The effects of nicotinic acid (2500 mg orally during 12 hr) and pyridoxine (300 mg orally twice daily for seven days) on the excretion of urinary 2,3-dinor-6-ketoprostaglandin F1alpha, 11-dehydrothromboxane B2 and leukotriene E4, the markers of systemic prostacyclin, thromboxane A2 and cysteinyl leukotriene production, respectively, were investigated in healthy male volunteers (n=6-8). Nicotinic a...<br/><br/>Virpi Saareks, Pauli Ylitalo, István Mucha, Asko Riutta (2002) <i>Pharmacol Toxicol</i> <i></i> <i></i> 90: 6 338-342<br/>

http://publicationslist.org/a.riutta/refid15 2009-10-01T09:36:33Z

It has previously been shown that leukotriene E4 production is increased both in acute and chronic lower limb ischaemia. The aim of this study was to measure the effect of revascularisation on leuktriene E4 excretion in chronic lower limb ischaemia. Revascularisation did not affect significantly on leukotriene E4 excretion (preop. 34.9+/-7.1 pg/mg creatinine, postop. 24.5+/-4.7 pg/mg creatinine, n...<br/><br/>P Rossi, P Kuukasjärvi, J P Salenius, A Riutta (2001) <i>Prostaglandins Leukot Essent Fatty Acids</i> <i></i> <i></i> 64: 6 289-290<br/>

http://publicationslist.org/a.riutta/refid17 2009-10-01T09:36:33Z

Functional and morphological changes of blood vessels in cyclosporine A (CsA)-induced hypertension and nephrotoxicity were studied in spontaneously hypertensive rats (SHR). The role of the L-arginine-nitric oxide (NO) pathway and the importance of oxidative stress in CsA toxicity were also assessed. SHR (7-8 week old) on a high-sodium diet were treated with CsA (5 mg kg(-1) d(-1) s.c.) for 6 weeks...<br/><br/>M Lassila, J Santisteban, P Finckenberg, P Salmenperä, A Riutta, E Moilanen, I Virtanen, H Vapaatalo, M L Nurminen (2001) <i>J Physiol Pharmacol</i> <i></i> <i></i> 52: 1 21-38<br/>

http://publicationslist.org/a.riutta/refid14 2009-10-01T09:36:33Z

Cysteinyl leukotrienes play a part in inflammatory reactions such as inflammatory bowel diseases. The aim of the present study was to evaluate the acute effects of a cys-leukotriene-1 receptor antagonist, montelukast, on trinitrobenzene sulphonic acid (TNBS)-induced colitis in rats. Montelukast (5, 10 or 20 mg kg(-1) day(-1)), a 5-lipoxygenase inhibitor, zileuton (50 or 100 mg kg(-1) day(-1), a po...<br/><br/>R Holma, P Salmenperä, A Riutta, I Virtanen, R Korpela, H Vapaatalo (2001) <i>Eur J Pharmacol</i> <i></i> <i></i> 429: 1-3 309-318<br/>

http://publicationslist.org/a.riutta/refid16 2009-10-01T09:36:33Z

This study investigated the effects of smoking cessation with and without nicotine substitution on the excretion of major urinary metabolites of thromboxane A2 and prostacyclin, 11-dehydrothromboxane B2 and 2,3-dinor-6-ketoprostaglandin F1alpha, respectively, as well as on the excretion of leukotriene E4 in man. Urine samples were obtained from 20 healthy non-smoking controls and from 60 healthy s...<br/><br/>V Saareks, P Ylitalo, J Alanko, I Mucha, A Riutta (2001) <i>Naunyn Schmiedebergs Arch Pharmacol</i> <i></i> <i></i> 363: 5 556-561<br/>

http://publicationslist.org/a.riutta/refid13 2009-10-01T09:36:33Z

This paper describes a new iodine-125 radioimmunoassay of 9alpha ,11beta-PGF2, and its use for the determination of urinary 9alpha,11beta-prostaglandin F2 after a selective one-step solid-phase extraction. The newly reported immunoassay is based on the use of 125I-tyrosyl methyl ester derivative of 9alpha,11beta-PGF2 and specific polyclonal antibody raised in rabbits.The assay detected as lowas 0....<br/><br/> Mucha, A Riutta (2001) <i>Prostaglandins Leukot Essent Fatty Acids</i> <i></i> <i></i> 65: 5-6 271-280<br/>

http://publicationslist.org/a.riutta/refid18 2009-10-01T09:36:33Z

Smoking is an important risk factor for respiratory and cardiovascular diseases. The role of numerous chemical, partly uncharacterised compounds existing in tobacco smoke is not known. (-)-Nicotine, its stereoisomer (+)-nicotine and main metabolite cotinine are biologically active compounds influencing e.g. catecholamine and eicosanoid systems. The precise mechanisms are not well known. The purpos...<br/><br/>V Saareks, A Riutta, J Alanko, P Ylitalo, M Parviainen, I Mucha, E Sievi, H Vapaatalo (2000) <i>J Physiol Pharmacol</i> <i></i> <i></i> 51: 4 Pt 1 631-642<br/>

http://publicationslist.org/a.riutta/refid54 2009-10-01T10:32:50Z

H Numminen, M Kobayashi, S Uchiyama, M Iwata, Y Takeda, A Riutta, M Syrjälä, M Kekomäki, M Hillbom (2000) <i>Alcohol Alcohol. </i> 35: 594-600<br/>

http://publicationslist.org/a.riutta/refid52 2009-10-01T10:17:41Z

Ilari Paakkari, Asko Riutta (2000) <i></i> 327-348<br/>

http://publicationslist.org/a.riutta/refid22 2009-10-01T09:36:33Z

Amrinone-a phosphodiesterase III inhibitor-is used in the treatment of acute heart failure. In addition to its hemodynamic effects, amrinone has been shown to inhibit thromboxane synthesis in vitro. We investigated the effects of amrinone on thromboxane, prostaglandin, and leukotriene synthesis in humans. Eight healthy male volunteers took part in this single-blind study in which either amrinone (...<br/><br/>T Kerttula, J Alanko, E Seppälä, A Riutta, I Mucha, E Sievi, S Kaukinen (1999) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 33: 1 140-143<br/>

http://publicationslist.org/a.riutta/refid21 2009-10-01T09:36:33Z

The effects of substituted catechols (3-methylcatechol, 4-methylcatechol, 4-nitrocatechol, and guaiacol) and trihydroxybenzenes (pyrogallol, propyl gallate, 1,2,4-trihydroxybenzene, and 1,3,5-trihydroxybenzene) on the synthesis of prostaglandin (PG)E2 and leukotriene (LT)B4 were tested in human A23187-stimulated polymorphonuclear leukocytes. The effects were related to their peroxyl-radical-scaven...<br/><br/>J Alanko, A Riutta, P Holm, I Mucha, H Vapaatalo, T Metsä-Ketelä (1999) <i>Free Radic Biol Med</i> <i></i> <i></i> 26: 1-2 193-201<br/>

http://publicationslist.org/a.riutta/refid19 2009-10-01T09:36:33Z

The in vitro effects of nicotinic acid (10-1000 microM), pyridoxine (0.1-500 microM) and pyridoxal-5'-phosphate (0.1-500 microM) and the ex vivo effects of nicotinic acid (2500 mg orally during 12 h) and pyridoxine (600 mg orally daily for seven days) on arachidonic acid metabolism were investigated in calcium ionophore A23187 (calcimycin)-stimulated human whole blood. In vitro nicotinic acid stim...<br/><br/>V Saareks, I Mucha, E Sievi, A Riutta (1999) <i>Pharmacol Toxicol</i> <i></i> <i></i> 84: 6 274-280<br/>

http://publicationslist.org/a.riutta/refid53 2009-10-01T10:29:05Z

P Arvola, X Wu, M Kähonen M, H Mäkynen, A Riutta, I Mucha, T Solakivi, H Kainulainen, I Pörsti (1999) <i>Cardiovasc Res</i> 43: 992-1002<br/>

http://publicationslist.org/a.riutta/refid20 2009-10-01T09:36:33Z

OBJECTIVE: To determine the dose of acetylsalicylic acid (ASA), that inhibits the production of the vasoconstrictive, aggregatory thromboxane A2 while sparing the production of the vasodilatory antiaggregatory prostacyclin. DESIGN: A controlled study comparing the effects of three doses of ASA on the production of thromboxane A2 and prostacyclin. METHODS: Seven pregnant hypertensive patients and f...<br/><br/>M Vainio, J Mäenpää, A Riutta, P Ylitalo, S L Ala-Fossi, R Tuimala (1999) <i>Acta Obstet Gynecol Scand</i> <i></i> <i></i> 78: 2 82-88<br/>

http://publicationslist.org/a.riutta/refid23 2009-10-01T09:36:33Z

OBJECTIVE: To compare the effects of unreamed and reamed intramedullary nailing on the systemic production of prostacyclin and thromboxane A2 as assessed, respectively, by determinations of urinary 2,3-dinor-6-ketoprostaglandin F1alpha and 11-dehydrothromboxane B2 excretion. METHODS: Ten otherwise healthy patients with closed and simple tibial shaft fractures were treated with unreamed intramedull...<br/><br/>T Lindström, E Gullichsen, A Riutta (1998) <i>J Trauma</i> <i></i> <i></i> 45: 4 743-746<br/>

http://publicationslist.org/a.riutta/refid24 2009-10-01T09:36:33Z

The effects of (-)-nicotine (0.0005-500 microM), (+)-nicotine (0.0005-50 microM) and (-)-cotinine (0.0005-500 microM) on arachidonic acid metabolism were investigated in Ca2+ ionophore A23187 (calcimycin)-stimulated human whole blood in vitro. (-)-Nicotine and (-)-cotinine stimulated prostaglandin E2 but inhibited thromboxane B2 synthesis, as has been observed previously in A23187-stimulated polym...<br/><br/>V Saareks, I Mucha, E Sievi, H Vapaatalo, A Riutta (1998) <i>Eur J Pharmacol</i> <i></i> <i></i> 353: 1 87-92<br/>

http://publicationslist.org/a.riutta/refid27 2009-10-01T09:36:33Z

Percutaneous transluminal angioplasty is an acute, local stimulus to platelets which activation is regarded as an important factor for a later restenosis. The balance between the production of prostacyclin and thromboxane A2 is of (patho)physiological importance due to their opposite actions on vascular tone and platelet reactivity. In this study we investigated the influence of percutaneous trans...<br/><br/>P Rossi, P Kuukasjärvi, J P Salenius, M Tarkka, T Kerttula, J Alanko, I Mucha, A Riutta (1997) <i>Prostaglandins Leukot Essent Fatty Acids</i> <i></i> <i></i> 56: 5 369-372<br/>

http://publicationslist.org/a.riutta/refid26 2009-10-01T09:36:33Z

OBJECTIVE: To evaluate the in vivo production of prostacyclin and thromboxane A2 during the initial phase of experimental fat embolism as assessed, respectively, by determinations of urine 2,3-dinor-6-ketoprostaglandin F1alpha and 11-dehydrothromboxane B2 excretion. DESIGN: Randomized, controlled trial. SETTING: Animal laboratory. SUBJECTS: Twenty seven domestic pigs, weighing 24 to 31 kg. INTERVE...<br/><br/>M Rautanen, E Gullichsen, A Riutta, K Kuttila, I Mucha, O Nelimarkka, J Niinikoski (1997) <i>Crit Care Med</i> <i></i> <i></i> 25: 7 1215-1221<br/>

http://publicationslist.org/a.riutta/refid25 2009-10-01T09:36:33Z

Although theophylline has been used in the treatment of asthma for decades, it is not a first line choice any more. It is a well-known bronchodilator, but was recently discovered also to be an anti-inflammatory, immunomodulatory and bronchoprotective agent. Therefore we wanted to establish the role of theophylline on prostaglandin and leukotriene production, which plays a part in the pathogenesis ...<br/><br/>T Kerttula, S Kaukinen, E Seppälä, A Riutta, I Mucha, P Ylitalo, J Alanko (1997) <i>Prostaglandins Leukot Essent Fatty Acids</i> <i></i> <i></i> 57: 6 555-560<br/>

http://publicationslist.org/a.riutta/refid28 2009-10-01T09:36:33Z

Prostacyclin (PGI2) and thromboxane A2 (TXA2) play an important role in the pathophysiology of various cardiovascular diseases. The balance between PGI2 and TXA2 regulates the interaction between platelets and the vessel wall in vivo. In this study we measured PGI2 and TXA2 synthesis by analysing their urinary index metabolites 2,3-dinor-6-keto-PGF1 alpha and 11-dehydro-TXB2, respectively, in acut...<br/><br/>P Rossi, P Kuukasjärvi, A Riutta, J P Salenius, M Tarkka, I Mucha, T Kerttula, J Alanko (1996) <i>Prostaglandins Leukot Essent Fatty Acids</i> <i></i> <i></i> 55: 6 433-436<br/>

http://publicationslist.org/a.riutta/refid34 2009-10-01T09:36:33Z

The aim of the present study was to investigate, whether nitric oxide (NO) modifies prostacyclin synthesis in endothelial cells. Two different NO-donors: SIN-1 (3-morpholino sydnonimine) and GEA 3175 (4-aryl-substituted oxatriazol derivative), and the NO-synthesis inhibitor; L-NAME were used. Endothelial cells were incubated with the tested compounds with or without Ca ionophore A23187 stimulation...<br/><br/>J Alanko, E Sievi, T Lähteenmäki, I Mucha, A Riutta, H Vapaatalo (1995) <i>Agents Actions Suppl</i> <i></i> <i></i> 45: 195-199<br/>

http://publicationslist.org/a.riutta/refid33 2009-10-01T09:36:33Z

The present study evaluated the effects of propofol and its solvent Intralipid on the immune response and in vivo prostaglandin E2 production in patients during induction of anaesthesia and in healthy volunteers after Intralipid injection. Fifteen female patients (median age 48 years, ASA 1-2) scheduled for uterine dilatation and curettage were randomly assigned to two groups. In group 1 propofol ...<br/><br/>C O Pirttikangas, M Salo, A Riutta, J Perttilä, O Peltola, O Kirvela (1995) <i>Anaesthesia</i> <i></i> <i></i> 50: 4 317-321<br/>

http://publicationslist.org/a.riutta/refid48 2009-10-01T10:05:24Z

Asko Riutta (1995) <br/>

http://publicationslist.org/a.riutta/refid30 2009-10-01T09:36:33Z

We have previously demonstrated that adrenaline infusion increases the thromboxane/leukotriene (TX/LT) ratio in whole blood in healthy volunteers. The aim of the present study was to see whether other catecholamines--noradrenaline and dopamine--are also capable of modulating arachidonic acid (AA) metabolism in man. Low doses of noradrenaline (0.025 microgram/kg/min) and dopamine (3.0 micrograms/kg...<br/><br/>T Kerttula, A Riutta, S Kaukinen, T Metsä-Ketelä, E Seppälä, H Vapaatalo, J Alanko (1995) <i>Prostaglandins Leukot Essent Fatty Acids</i> <i></i> <i></i> 53: 1 47-52<br/>

http://publicationslist.org/a.riutta/refid29 2009-10-01T09:36:33Z

We infused noradrenaline (0.025 micrograms/kg/min for 60 min, n=7) and dopamine (3.0 micrograms/kg/min for 60 min, n=6) into healthy male volunteers to study the effects of these catecholamines on in vivo thromboxane A2, prostacyclin and leukotriene E4 production measured as urinary excretions of 11-dehydro-thromboxane (TX) B2, 2,3-dinor-6-keto-prostaglandin (PG) F1alpha and leukotriene (LT) E4, r...<br/><br/>T Kerttula, S Kaukinen, A Riutta, E Seppälä, I Mucha, H Vapaatalo, J Alanko (1995) <i>Thromb Res</i> <i></i> <i></i> 80: 2 169-178<br/>

http://publicationslist.org/a.riutta/refid31 2009-10-01T09:36:33Z

The effects of smoking cessation with and without nicotine substitution on prostaglandin E2, leukotriene B4, leukotriene E4, and thromboxane B2 synthesis ex vivo in man were investigated. Blood samples were obtained from 20 healthy non-smoking controls and from 30 healthy smoking volunteers before and 3, 7 and 14 days after smoking cessation. Half of the smokers used nicotine chewing gum as a subs...<br/><br/>A Riutta, V Saareks, I Mucha, J Alanko, M Parviainen, H Vapaatalo (1995) <i>Naunyn Schmiedebergs Arch Pharmacol</i> <i></i> <i></i> 352: 1 102-107<br/>

http://publicationslist.org/a.riutta/refid32 2009-10-01T09:36:33Z

We have previously demonstrated that the phenolic compounds catechol, hydroquinone, and phenol increase the prostaglandin (PG) E2/leukotriene (LT) B4 ratio in human polymorphonuclear leukocytes (PMNs), while resorcinol has the opposite effect. However, in human whole blood phenols have a different effect on the thromboxane (TX) B2/LT ratio than in PMNs on the PGE2/LTB4 ratio. To establish whether ...<br/><br/>J Alanko, A Riutta, H Vapaatalo (1995) <i>Prostaglandins Leukot Essent Fatty Acids</i> <i></i> <i></i> 52: 5 299-301<br/>

http://publicationslist.org/a.riutta/refid37 2009-10-01T09:36:33Z

We have previously shown that adrenaline infusion induces an almost twofold increase in systemic thromboxane synthesis, measured as urinary 11-dehydrothromboxane B2. The purpose of the present study was to investigate whether high levels of adrenaline, found e.g. in heavy physical exercise and myocardial infarction are involved in the regulation of prostacyclin synthesis. To this end the effect of...<br/><br/>A Riutta, T Kerttula, E Sievi, J Alanko (1994) <i>Prostaglandins</i> <i></i> <i></i> 48: 1 43-51<br/>

http://publicationslist.org/a.riutta/refid36 2009-10-01T09:36:33Z

This paper describes a method for selective two-step solid-phase extraction of urinary 2,3-dinor-6-ketoprostaglandin F1 alpha for reliable determination with radioimmunoassay. In the immunoreactivity profile of non-selectively extracted urine after HPLC separation, over 90% of the total 2,3-dinor-6-ketoprostaglandin F1 alpha immunoreactivity consisted of interfering material coeluting with 6-ketop...<br/><br/>A Riutta, E Nurmi, C Weber, G Hansson, H Vapaatalo, I Mucha (1994) <i>Anal Biochem</i> <i></i> <i></i> 220: 2 351-359<br/>

http://publicationslist.org/a.riutta/refid35 2009-10-01T09:36:33Z

The effects of Trolox C (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid), a vitamin E analogue, (60-900 microM) and SIN-1 (3-morpholino sydnonimine), a nitric oxide donor, (30-3000 microM) on arachidonic acid metabolism and on cyclic GMP formation in calcium ionophore A23187 (calcimycin)-stimulated human polymorphonuclear leukocytes were investigated. Trolox C elicited a dose dependent dec...<br/><br/>A Riutta, J Alanko, I Mucha, H Vapaatalo (1994) <i>Eur J Pharmacol</i> <i></i> <i></i> 262: 3 217-222<br/>

http://publicationslist.org/a.riutta/refid38 2009-10-01T09:36:33Z

We investigated the effects of nicotine and cotinine (0.5 nM-0.5 mM) on prostaglandin E2 and leukotriene B4 production in human polymorphonuclear leukocytes and on thromboxane B2 formation in human platelet-rich plasma, stimulated by calcium ionophore A23187. Nicotine and cotinine dose-dependently increased prostaglandin E2 synthesis in polymorphonuclear leukocytes from 25% (0.5 nM) up to nearly f...<br/><br/>V Saareks, A Riutta, I Mucha, J Alanko, H Vapaatalo (1993) <i>Eur J Pharmacol</i> <i></i> <i></i> 248: 4 345-349<br/>

http://publicationslist.org/a.riutta/refid39 2009-10-01T09:36:33Z

We have shown earlier that catecholamines have opposite regulative effects on prostaglandin (PG)E2 and leukotriene (LT)B4 formation with a receptor-independent mechanism in human polymorphonuclear leukocytes (PMNs) and whole blood. To shed further light on the mechanisms involved and structure-action relationship, we tested the effects of phenols (catechol, hydroquinone, phenol, and resorcinol) on...<br/><br/>J Alanko, A Riutta, I Mucha, H Vapaatalo, T Metsä-Ketelä (1993) <i>Free Radic Biol Med</i> <i></i> <i></i> 14: 1 19-25<br/>

http://publicationslist.org/a.riutta/refid42 2009-10-01T09:36:33Z

Catecholamines and other catecholic compounds have opposite effects on the cyclooxygenase and 5-lipoxygenase pathways of arachidonic acid metabolism in human polymorphonuclear leukocytes and whole blood in vitro. The hypothesis that high levels of adrenaline, found e.g. in myocardial infarction, are involved in the regulation of arachidonic acid metabolism was tested. Adrenaline (0.1 micrograms/kg...<br/><br/>J Alanko, A Riutta, I Mucha, T Kerttula, S Kaukinen, H Vapaatalo, T Metsä-Ketelä, E Seppälä (1992) <i>Eicosanoids</i> <i></i> <i></i> 5: 3-4 169-175<br/>

http://publicationslist.org/a.riutta/refid41 2009-10-01T09:36:33Z

In this paper we elaborate a one-step procedure for the selective extraction of urinary 11-dehydrothromboxane B2 on octylsilyl silica cartridges for reliable determination with radioimmunoassay. The immunoreactivity profile of nonselectively extracted urine after HPLC separation showed that as much as 70% of the total 11-dehydrothromboxane B2 immunoreactivity comigrates with polar interfering mate...<br/><br/>A Riutta, I Mucha, H Vapaatalo (1992) <i>Anal Biochem</i> <i></i> <i></i> 202: 2 299-305<br/>

http://publicationslist.org/a.riutta/refid40 2009-10-01T09:36:33Z

Catecholamines (adrenaline, dopamine, and noradrenaline) stimulate prostanoid synthesis by acting as "cosubstrates." On the other hand, many inhibitors of leukotriene synthesis, such as nordihydroguaiaretic acid and caffeic acid, have a catecholic structure. Catecholamines have opposite effects on prostanoid and leukotriene synthesis in human polymorphonuclear leukocytes and whole blood. Basic phe...<br/><br/>J Alanko, A Riutta, H Vapaatalo (1992) <i>Free Radic Biol Med</i> <i></i> <i></i> 13: 6 677-688<br/>

http://publicationslist.org/a.riutta/refid47 2009-10-01T10:01:31Z

Istvan Mucha, Asko Riutta, Heikki Vapaatalo (1991) <i>Eicosanoids</i> 4: 1-7<br/>

http://publicationslist.org/a.riutta/refid44 2009-10-01T09:36:33Z

The determination of 11-dehydrothromboxane B2 (11-dehydro-TXB2) from unextracted human urine was studied by means of a specific radioimmunoassay based on the use of the 125I-labelled tyrosine methyl ester derivative of 11-dehydro-TXB2 as radioligand. The assay was evaluated in various incubation media by either dextran-coated charcoal (DCC) or polyethylene glycol (PEG) separation. Both the non-spe...<br/><br/>I Mucha, A Riutta, H Vapaatalo (1991) <i>Eicosanoids</i> <i></i> <i></i> 4: 1 1-7<br/>

http://publicationslist.org/a.riutta/refid43 2009-10-01T09:36:33Z

Catecholamines (adrenaline, dopamine, isoprenaline, noradrenaline) and caffeic acid (catecholic compound without adrenergic receptor activity) decreased leukotriene (LT)B4 synthesis in A23187-stimulated human whole blood. Salbutamol, a non-catecholic beta 2-adrenergic agonist, did not influence LTB4 synthesis. Catecholamines stimulated thromboxane (TX)B2 synthesis with a concomitant inhibition of ...<br/><br/>J Alanko, A Riutta, H Vapaatalo, I Mucha (1991) <i>Prostaglandins</i> <i></i> <i></i> 42: 3 279-287<br/>

http://publicationslist.org/a.riutta/refid51 2009-10-01T10:14:14Z

Asko Riutta (1983) <i>Duodecim</i> 99: 1254-1255<br/>

http://publicationslist.org/a.riutta/refid46 2009-10-01T09:59:18Z

Asko Riutta, Erkki Seppälä, Heikki Vapaatalo (1983) <i>J Chromatogr</i> 307: 185-189<br/>