http://publicationslist.org/data/alain.simon/atom.xml alain simonhttp://publicationslist.org/alain.simon$basepathfavicon.icoRecent additions to alain simon's PublicationsList.org pagehttp://publicationslist.org/publications.png2013-02-09T13:59:16Z http://publicationslist.org/alain.simon/refid331 2013-02-09T13:57:38Z

Gilles Chironi, Alain Simon (2013) <i>Arch Cardiovasc Dis</i> <i></i> <i></i> 106: 1 1-3<br/>

http://publicationslist.org/alain.simon/refid333 2013-02-09T13:57:38Z

Aging produces a simultaneous thoracic aorta (TA) enlargement and unfolding. We sought to analyze the impact of hypertension on these geometric changes. Non-contrast computed tomography images were obtained from coronary artery calcium scans, including the entire aortic arch, in 200 normotensive and 200 hypertensive asymptomatic men. An automated algorithm reconstructed the vessel in three-dimensi...<br/><br/>D Craiem, G Chironi, M E Casciaro, A Redheuil, E Mousseaux, A Simon (2013) <i>J Hum Hypertens</i> <i></i> <i></i> : <br/>

http://publicationslist.org/alain.simon/refid335 2013-02-09T13:57:38Z

An increasing number of intermediate risk asymptomatic subjects benefit from measures of atherosclerosis burden like coronary artery calcification studies with non-contrast heart computed tomography (CT). However, additional information can be derived from these studies, looking beyond the coronary arteries and without exposing the patients to further radiation. We report a semi-automatic method t...<br/><br/>Damian Craiem, Gilles Chironi, Alban Redheuil, Mariano Casciaro, Elie Mousseaux, Alain Simon, Ricardo L Armentano (2012) <i>Ann Biomed Eng</i> <i></i> <i></i> 40: 5 1028-1038<br/>

http://publicationslist.org/alain.simon/refid332 2013-02-09T13:57:38Z

Measures of atherosclerosis burden like coronary artery calcification are performed using non-contrast heart CT. However, additional information can be derived from these studies, looking beyond the coronary arteries without exposing the patients to further radiation. We present a semi-automated method to assess ascending, arch and descending aorta geometry from non-contrast CT datasets in 250 nor...<br/><br/>Damian Craiem, Mariano E Casciaro, Sebastian Graf, Gilles Chironi, Alain Simon, Ricardo L Armentano (2012) <i>Conf Proc IEEE Eng Med Biol Soc</i> <i></i> <i></i> 2012: 4986-4989<br/>

http://publicationslist.org/alain.simon/refid334 2013-02-09T13:57:38Z

To assess the influence of cardiovascular risk factors on arterial wall growth and the remodeling process.<br/><br/>Plamen Bokov, Gilles Chironi, Ludmila Orobinskaia, Patrice Flaud, Alain Simon (2012) <i>J Clin Ultrasound</i> <i></i> <i></i> 40: 8 486-494<br/>

http://publicationslist.org/alain.simon/refid336 2013-02-09T13:57:38Z

Membrane-shed submicron microparticles (MPs) are released after cell activation or apoptosis. High levels of MPs circulate in the blood of patients with atherothrombotic diseases, where they could serve as a useful biomarker of vascular injury and a potential predictor of cardiovascular mortality and major adverse cardiovascular events. Atherosclerotic lesions also accumulate large numbers of MPs ...<br/><br/>Pierre-Emmanuel Rautou, Anne-Clémence Vion, Nicolas Amabile, Gilles Chironi, Alain Simon, Alain Tedgui, Chantal M Boulanger (2011) <i>Circ Res</i> <i></i> <i></i> 109: 5 593-606<br/>

http://publicationslist.org/alain.simon/refid325 2011-01-01T08:59:52Z

To test associations of circulating microparticles with large artery remodeling before atherosclerosis is detectable.<br/><br/>Gilles N Chironi, Alain Simon, Chantal M Boulanger, Françoise Dignat-George, Bénédicte Hugel, Jean-Louis Megnien, Muriel Lefort, Jean-Marie Freyssinet, Alain Tedgui (2010) <i>J Hypertens</i> <i></i> <i></i> 28: 4 789-796<br/>

http://publicationslist.org/alain.simon/refid337 2013-02-09T13:57:38Z

Gilles Chironi, Alain Simon (2010) <i>Rev Prat</i> <i></i> <i></i> 60: 9 1303-1309<br/>

http://publicationslist.org/alain.simon/refid323 2010-02-21T09:47:14Z

We reviewed prospective epidemiological data in the general population, mostly middle-aged to older persons, to determine the association of carotid intima-media thickness (CIMT) (assessed by B-mode ultrasonography) with cardiovascular risk. Reported risks were expressed as absolute (event risk per persons-years in subjects with a high CIMT) and relative (hazard ratio of high vs low CIMT). They we...<br/><br/>Alain Simon, Jean-Louis Megnien, Gilles Chironi (2010) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 30: 2 182-185<br/>

http://publicationslist.org/alain.simon/refid326 2010-04-10T09:36:47Z

Alain Simon, Gilles Chironi, Jean-Louis Megnien (2010) <i>Hypertension</i> <i></i> <i></i> 55: 4 840-841<br/>

http://publicationslist.org/alain.simon/refid329 2013-02-09T13:57:38Z

Epidemiological studies suggest that apple consumption is associated with a reduction in cardiovascular disease risk. Apple polyphenols may contribute to explain these effects. Endothelial dysfunction has been associated with early stage of atherosclerosis and polyphenols from various dietary sources have been shown to reverse it. The aim of the present study was to investigate the effect of the c...<br/><br/>S Auclair, G Chironi, D Milenkovic, P C H Hollman, C M G C Renard, J-L Mégnien, J Gariepy, J-L Paul, A Simon, A Scalbert (2010) <i>Eur J Clin Nutr</i> <i></i> <i></i> 64: 10 1158-1165<br/>

http://publicationslist.org/alain.simon/refid330 2013-02-09T13:57:38Z

We analyzed, in above-average risk asymptomatic individuals, the factors determining early thoracic aorta enlargement.<br/><br/>Gilles Chironi, Ludmila Orobinskaia, Jean-Louis Mégnien, Marie-Emmanuelle Sirieix, Stéphanie Clément-Guinaudeau, Mourad Bensalah, Arshid Azarine, Elie Mousseaux, Alain Simon (2010) <i>J Hypertens</i> <i></i> <i></i> 28: 10 2134-2138<br/>

http://publicationslist.org/alain.simon/refid327 2013-02-09T13:57:38Z

The ambulatory arterial stiffness index (AASI) is claimed to be a new estimator for arterial rigidity. It was recently defined as one minus the slope of the linear regression of systolic to diastolic ambulatory pressure during 24 h. Although several reports testify its clinical relevance, the explanation of how this new index is conceptually associated with arterial stiffness remains controversial...<br/><br/>Damian Craiem, Sebastian Graf, Fernando Salvucci, Gilles Chironi, Jean-Louis Megnien, Alain Simon, Ricardo L Armentano (2010) <i>Physiol Meas</i> <i></i> <i></i> 31: 7 1037-1046<br/>

http://publicationslist.org/alain.simon/refid328 2011-01-01T09:02:17Z

BACKGROUND: Application of coronary artery calcium (CAC) for stratifying coronary heart disease (CHD) risk may change the proportion of subjects eligible for risk reduction treatment and decrease cost-effectiveness of primary prevention. We therefore aimed to analyze the impact of CAC on CHD risk categorization. METHODS: We measured CAC with electron beam computed tomography in 500 asymptomatic un...<br/><br/>Gilles Chironi, Alain Simon, Jean-Louis Megnien, Marie-Emmanuelle Sirieix, Elie Mousseaux, Franco Pessana, Ricardo Armentano (2010) <i>Int J Cardiol</i> <i></i> <i></i> : <br/>

http://publicationslist.org/alain.simon/refid318 2009-09-05T06:41:18Z

PURPOSE: Early artery wall-thickening detected by ultrasound-assessed increased carotid intima-media thickness (IMT) may reflect atherosclerosis or represent an adaptive response to keep homeostasis tensile stress that is related inversely to wall thickness by Laplace's equation. We attempted to discriminate between both mechanisms by correcting IMT for its inverse association with tensile stress....<br/><br/>Gilles N Chironi, Alain Simon, Plamen Bokov, Jaime Levenson (2009) <i>J Clin Ultrasound</i> <i></i> <i></i> 37: 5 270-275<br/>

http://publicationslist.org/alain.simon/refid320 2009-06-13T06:07:20Z

BACKGROUND: Patients with type IIb, or mixed, dyslipidemia have high levels of low-density lipoprotein cholesterol (LDL-C) with predominance of small dense LDL particles, high levels of triglycerides (TG), and low levels of high-density lipoprotein cholesterol (HDL-C). Fenofibrate significantly reduces TG and, more moderately, LDL-C, increases HDL-C and produces a shift from small to large LDL par...<br/><br/>Jean-Claude Ansquer, Ivan Bekaert, Martine Guy, Markolf Hanefeld, Alain Simon (2009) <i>Am J Cardiovasc Drugs</i> 9: 2 91-101<br/>

http://publicationslist.org/alain.simon/refid317 2010-02-21T09:47:14Z

In symptom-free subjects, exercise tolerance testing (ETT) has a doubtful utility for detecting latent coronary heart disease (CHD) because of frequent false positives, but it may be valuable for predicting future CHD. To clarify the latter question, we calculated CHD incidence associated with presence or absence of ETT-induced abnormalities of ST-segment depression, exercise capacity, and heart r...<br/><br/>Jean-Louis Mégnien, Alain Simon (2009) <i>Atherosclerosis</i> <i></i> <i></i> 205: 2 579-583<br/>

http://publicationslist.org/alain.simon/refid316 2009-09-05T06:44:23Z

Microparticles are submicron vesicles shed from plasma membranes in response to cell activation, injury, and/or apoptosis. The measurement of the phospholipid content (mainly phosphatidylserine; PSer) of microparticles and the detection of proteins specific for the cells from which they are derived has allowed their quantification and characterization. Microparticles of various cellular origin (pl...<br/><br/>Gilles N Chironi, Chantal M Boulanger, Alain Simon, Françoise Dignat-George, Jean-Marie Freyssinet, Alain Tedgui (2009) <i>Cell Tissue Res</i> <i></i> <i></i> 335: 1 143-151<br/>

http://publicationslist.org/alain.simon/refid324 2010-05-15T08:55:12Z

Medical prevention consists to identify as soon as possible apparently healthy individuals who develop a disease and to engage them for active preventive treatment. Several cross-sectional studies of general populations or high cardiovascular risk have shown that coronary calcium score (coronary artery calcium, CAC) was positively associated with traditional risk factors (hypertension, dyslipidemi...<br/><br/>F Pessana, R Armentano, G Chironi, J L Megnien, E Mousseaux, A Simon (2009) <i>Conf Proc IEEE Eng Med Biol Soc</i> <i></i> <i></i> 2009: 5348-5351<br/>

http://publicationslist.org/alain.simon/refid321 2009-09-05T06:41:18Z

INTRODUCTION AND OBJECTIVES: Echographic studies of the composition of atheromatous plaque make use of the median gray level, which provides an overall measure of echogenicity. We propose adding an additional dimension to this approach by dividing the lesion into layers and generating a curve that shows the variation in echolucency with depth. METHODS: Femoral and carotid plaque in asymptomatic pa...<br/><br/> Craiem, Chironi, Graf, Denarié, Armentano, Simon (2009) <i>Rev Esp Cardiol</i> <i></i> <i></i> 62: 9 984-991<br/>

http://publicationslist.org/alain.simon/refid322 2010-05-15T08:55:12Z

BACKGROUND: Postulating that serotonin (5-HT), released from smoking-activated platelets could be involved in smoking-induced vascular modifications, we studied its catabolism in a series of 115 men distributed as current smokers (S), never smokers (NS) and former smokers (FS) who had stopped smoking for a mean of 13 years. METHODOLOGY/PRINCIPAL FINDINGS: 5-HT, monoamine oxidase (MAO-B) activities...<br/><br/>Jean-Marie Launay, Muriel Del Pino, Gilles Chironi, Jacques Callebert, Katell Peoc'h, Jean-Louis Mégnien, Jacques Mallet, Alain Simon, Francine Rendu (2009) <i>PLoS One</i> <i></i> <i></i> 4: 11 <br/>

http://publicationslist.org/alain.simon/refid307 2009-08-28T15:38:19Z

BACKGROUND: Obesity increases the risk of cardiovascular diseases and diabetes. OBJECTIVE: To determine which measure of adiposity, body mass index (BMI), waist circumference (WC) or body fat mass (BFM) is the most predictive of the coronary heart disease (CHD) risk and of the presence of the metabolic syndrome. METHODS: A cross-sectional study of 649 consecutive men and women aged 22-79 years, in...<br/><br/>Nathalie Dervaux, Murine Wubuli, Jean-Louis Megnien, Gilles Chironi, Alain Simon (2008) <i>Atherosclerosis</i> <i></i> <i></i> 201: 2 413-417<br/>

http://publicationslist.org/alain.simon/refid304 2008-12-27T10:28:43Z

Hypertriglyceridemia being an independent cardiovascular risk factor, we have compared the potential of sera from asymptomatic hypertriglyceridemic (HTG) type IIb, type IV or normolipidemic (NLP) subjects to promote both fractional cholesterol efflux and cellular cholesterol mass changes using macrophage foam cells. The J774 cells loaded with cholesterol by incubation with acetylated LDL were incu...<br/><br/>Nesrine Attia, Angela Ramaharo, Jean-Louis Paul, Michèle Cambillau, Philippe Beaune, Alain Grynberg, Alain Simon, Natalie Fournier (2008) <i>Atherosclerosis</i> 198: 1 49-56<br/>

http://publicationslist.org/alain.simon/refid313 2008-04-26T08:32:24Z

OBJECTIVES: Our aim was to analyze flow-mediated dilation (FMD) time-course in response to forearm occlusion in the clinical setting. METHODS AND RESULTS: In 50 asymptomatic subjects, monitoring software measuring continuous beat-to-beat change in brachial artery diameter was used to determine FMD magnitude in percentage change in peak diameter from baseline (FMD-DeltaD), time to peak diameter aft...<br/><br/>Gilles Chironi, Damian Craiem, Janiffer Miranda-Lacet, Jaime Levenson, Alain Simon (2008) <i>J Hypertens</i> 26: 3 508-515<br/>

http://publicationslist.org/alain.simon/refid315 2008-09-21T14:09:21Z

The vascular endothelium plays an important role in the regulation of vascular tone, cell growth, inflammation, and thrombogenicity. Endothelium dysfunction, then, is considered to promote several disorders that initiate the atherosclerosis process. Vascular tone dysfunction can be determined by high-resolution ultrasonographic imaging of the brachial artery, enabling one to assess endothelium-dep...<br/><br/>Damian Craiem, Gilles Chironi, Alain Simon, Jaime Levenson (2008) <i>Am J Ther</i> 15: 4 340-344<br/>

http://publicationslist.org/alain.simon/refid314 2009-03-21T06:52:41Z

In this study we evaluate early atherosclerotic changes and determine whether anti-HSP-60, anti-HSP-65 and anti-oxLDL autoantibodies are elevated in systemic necrotizing vasculitis. Thirty-two patients having systemic necrotizing vasculitis were compared with normal controls and patients with systemic lupus erythematosus (SLE). The antibodies against human HSP-60, HSP-65 and oxLDL were measured by...<br/><br/>Yaniv Sherer, Christian Pagnoux, Gilles Chironi, Alain Simon, Loïc Guillevin, Luc Mouthon, Boris Gilburd, Yehuda Shoenfeld (2008) <i>Rheumatol Int</i> <i></i> <i></i> 28: 11 1099-1103<br/>

http://publicationslist.org/alain.simon/refid3 2008-02-23T18:06:18Z

BACKGROUND: Enhanced external counterpulsation (EECP) is a noninvasive method previously shown to improve measures of myocardial ischemia in patients with coronary artery disease. However, the concomitant effects of EECP on large and small arterial properties have been poorly examined. In a randomized controlled study, we investigated whether arterial stiffness and resistance of the carotid circul...<br/><br/>Jaime Levenson, Alain Simon, Jean L Megnien, Gilles Chironi, Jerome Gariepy, Marie G Pernollet, Damian Craiem, Marie C Iliou (2007) <i>Cardiology</i> <i></i> <i></i> 108: 2 104-110<br/>

http://publicationslist.org/alain.simon/refid302 2008-02-23T18:06:18Z

It is currently accepted that atherosclerosis is rather, or also, an inflammatory disease and, indeed, vasculitis is defined by inflammatory infiltrates in blood vessel walls, albeit initially by different predominant cell populations and in arteries of different calibers. As for other chronic systemic inflammatory diseases, premature and accelerated atherosclerosis has emerged during the last 5-1...<br/><br/>Christian Pagnoux, Gilles Chironi, Alain Simon, Loïc Guillevin (2007) <i>Ann N Y Acad Sci</i> <i></i> <i></i> 1107: 11-21<br/>

http://publicationslist.org/alain.simon/refid301 2008-09-15T14:50:32Z

Alain Simon, Gilles Chironi (2007) <i>Eur Heart J</i> <i></i> <i></i> 28: 17 2049-2050<br/>

http://publicationslist.org/alain.simon/refid303 2008-04-12T16:25:46Z

The prognostic performance of subclinical atherosclerosis in predicting coronary heart disease (CHD) needs to be clarified because of the existence of many non-invasive tests available for its detection in the clinical setting: ultrasound measurement of carotid intima-media thickness (IMT) and plaque, cardiac computed tomography assessment of coronary artery calcium, Doppler stethoscope measuremen...<br/><br/>Alain Simon, Gilles Chironi, Jaime Levenson (2007) <i>Eur Heart J</i> 28: 24 2967-2971<br/>

http://publicationslist.org/alain.simon/refid1 2008-02-23T18:06:18Z

BACKGROUND: The reproducibility of brachial artery flow-mediated vasodilatation (FMD) is limited by the operator dependence of most measurement methods. METHODS: A new automated computerized analysis of brachial artery ultrasound scan providing a continuous evolution of the diameter during acute hyperemia, reactive to short hyperemia of the forearm and hand, was tested in 10 normal volunteers and ...<br/><br/>Damian Craiem, Gilles Chironi, Jerome Gariepy, Jennifer Miranda-Lacet, Jaime Levenson, Alain Simon (2007) <i>J Hypertens</i> <i></i> <i></i> 25: 1 133-140<br/>

http://publicationslist.org/alain.simon/refid241 2008-02-02T11:58:39Z

AIMS: Measurement of change in carotid intima-media thickness (CIMT) has been proposed as an alternative for the occurrence of cardiovascular (CV) events in the assessment of therapeutic interventions. Nevertheless, criticism has been voiced based on observations indicating a weak relation between CIMT and coronary atherosclerosis as well as on the virtual absence of data showing that progression ...<br/><br/>Michiel L Bots, Damiano Baldassarre, Alain Simon, Eric de Groot, Daniel H O'Leary, Ward Riley, John J Kastelein, Diederick E Grobbee (2007) <i>Eur Heart J</i> <i></i> <i></i> 28: 4 398-406<br/>

http://publicationslist.org/alain.simon/refid6 2008-02-23T18:06:18Z

OBJECTIVES: To assess whether circulating endothelial progenitor cells (CEPCs) can be considered as a cardiovascular risk marker before event has occurred, that is less firmly established than in clinically overt atherosclerosis. METHODS: Number of CD34+KDR+ cell number per ml blood was measured by flow cytometry in 84 untreated subjects without cardiovascular disease. Atherosclerotic plaque was d...<br/><br/>Gilles Chironi, Laurence Walch, Marie-Gabrielle Pernollet, Jérôme Gariepy, Jaime Levenson, Francine Rendu, Alain Simon (2007) <i>Atherosclerosis</i> <i></i> <i></i> 191: 1 115-120<br/>

http://publicationslist.org/alain.simon/refid237 2008-02-23T18:06:18Z

BACKGROUND AND OBJECTIVE: Although changes in smaller vessels is the hallmark of medium-sized and small-vessel vasculitis, it has been suggested that large arteries of such patients may also be affected by the early atherosclerotic process because of coexisting risk factors or systemic inflammation. This study aimed to bring additional arguments supporting this hypothesis. DESIGN, SETTING AND PATI...<br/><br/>G Chironi, C Pagnoux, A Simon, M Pasquinelli-Balice, M Del-Pino, J Gariepy, L Guillevin (2007) <i>Heart</i> <i></i> <i></i> 93: 1 96-99<br/>

http://publicationslist.org/alain.simon/refid7 2008-02-23T18:06:18Z

Current possibilities for better detecting high risk of coronary heart disease (CHD) and stroke and peripheral arterial disease are described in this review. A first step is based on risk factors assessment that allows establishing high-risk diagnostic, either by detecting a condition termed as "CHD risk equivalent" and defined by one or more severe major risk factor, or by calculating multifactor...<br/><br/>Alain Simon, Wuliya Mijiti, Jerome Gariepy, Jaime Levenson (2006) <i>Int J Cardiol</i> <i></i> <i></i> 110: 2 146-152<br/>

http://publicationslist.org/alain.simon/refid5 2008-02-23T18:06:18Z

BACKGROUND: Enhanced external counterpulsation (EECP) is a noninvasive, pneumatic technique that provides favorable effects in patients with coronary artery disease and heart failure. The mechanisms by which EECP exerts its beneficial effects remain poorly understood. Cyclic GMP (cGMP) regulates vascular smooth muscle tone that may improve arterial function. We investigated the effect of a single ...<br/><br/>Jaime Levenson, Marie G Pernollet, Marie C Iliou, Marie A Devynck, Alain Simon (2006) <i>Am J Hypertens</i> <i></i> <i></i> 19: 8 867-872<br/>

http://publicationslist.org/alain.simon/refid4 2008-02-23T18:06:18Z

Traditional risk factors are poor screening tests for coronary heart disease, whereas clinical arterial disease represents its strongest predictor. This raises the question whether subclinical arterial disease may also predict coronary disease. Using published data of prospective studies of subclinical arterial disease, we calculated the incidence of coronary event associated with the absence or p...<br/><br/>Alain Simon, Gilles Chironi, Jaime Levenson (2006) <i>Hypertension</i> <i></i> <i></i> 48: 3 392-396<br/>

http://publicationslist.org/alain.simon/refid236 2008-02-23T18:06:18Z

OBJECTIVE: To clarify circulating microparticles (MP) relationships with preclinical atherosclerosis. METHODS AND RESULTS: In 216 subjects without cardiovascular disease, we assessed: (1) annexin V-positive, platelet-derived, endothelium-derived and leukocyte-derived circulating MP by capture on annexin V, anti-GPIb, anti-CD105, and anti-CD11a antibody-coated wells, respectively; (2) Framingham ri...<br/><br/>Gilles Chironi, Alain Simon, Bénédicte Hugel, Muriel Del Pino, Jérôme Gariepy, Jean-Marie Freyssinet, Alain Tedgui (2006) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 26: 12 2775-2780<br/>

http://publicationslist.org/alain.simon/refid2 2008-02-23T18:06:18Z

BACKGROUND: Relations of mediators of inflammation and hemostasis with preclinical atherosclerosis have been poorly analyzed. The aim of this study was to test potential associations of these blood markers with indicators of cardiovascular risk and atherosclerotic burden in asymptomatic, nonsmoking, hypercholesterolemic men. METHODS: A total of 87 men underwent cardiovascular risk assessment by me...<br/><br/>Gilles Chironi, Christine Dosquet, Muriel Del-Pino, Nicolas Denarie, Jean-Louis Megnien, Ludovic Drouet, Claire Bal dit Sollier, Jaime Levenson, Alain Simon (2006) <i>Am J Hypertens</i> <i></i> <i></i> 19: 10 1025-1031<br/>

http://publicationslist.org/alain.simon/refid305 2007-12-22T16:14:48Z

BACKGROUND: Fu5AH rat hepatoma cells and cAMP (cyclic AMP)-pretreated J774 mouse macrophages are commonly used as models for SR-BI (scavenger receptor class B type I) and ABCA1 (ATP binding cassette transporter 1)-mediated free cholesterol efflux to whole serum, respectively. However, the responsiveness of Fu5AH, control or cAMP pretreated J774 cells to the various lipids and HDL (high-density lip...<br/><br/>S Mweva, J L Paul, M Cambillau, D Goudouneche, P Beaune, A Simon, N Fournier (2006) <i>Eur J Clin Invest</i> <i></i> <i></i> 36: 8 552-559<br/>

http://publicationslist.org/alain.simon/refid9 2008-02-23T18:06:18Z

The diagnosis of high risk of cardiovascular disease (CVD) in subjects without clinically overt CVD has been somewhat improved by integrating multiple traditional risk factors via appropriate risk score programs. Nevertheless, novel measures of CVD risk are being proposed and debated to further improve high-risk detection by their addition to, or their use in place of, traditional risk factors. Am...<br/><br/>Alain Simon, Jaime Levenson (2005) <i>J Hypertens</i> <i></i> <i></i> 23: 11 1939-1945<br/>

http://publicationslist.org/alain.simon/refid10 2008-02-23T18:06:18Z

OBJECTIVE: As main markers of atherogenic lipoproteins, apolipoprotein B (apoB), non-HDL cholesterol (non-HDLC), and LDL cholesterol (LDLC) do not seem equipotent to predict cardiovascular complications, we have compared simultaneously their capacity to predict high cardiovascular risk and subclinical atherosclerosis in a primary prevention population. METHODS: In 723 asymptomatic men, we measured...<br/><br/>Alain Simon, Gilles Chironi, Jerome Gariepy, Muriel Del Pino, Jaime Levenson (2005) <i>Atherosclerosis</i> <i></i> <i></i> 179: 2 339-344<br/>

http://publicationslist.org/alain.simon/refid8 2008-02-23T18:06:18Z

BACKGROUND: The effects of statins on intima-media thickness (IMT) are well documented, whereas those of fibrates are unknown. Therefore we compared IMT under treatment with each class of drugs. METHODS: We studied a cohort of consecutive dyslipidemic subjects treated with statin (n = 291) or fibrate (n = 82) drugs. Fibrate-treated subjects were matched with the same number of statin-treated subje...<br/><br/>Gilles Chironi, Alain Simon, Jérome Gariepy, Maria Balice, Muriel Del-Pino, Jaime Levenson (2005) <i>Am J Hypertens</i> <i></i> <i></i> 18: 11 1476-1481<br/>

http://publicationslist.org/alain.simon/refid12 2008-02-23T18:06:18Z

AIM: We determined the wall mechanical response of the pulmonary artery (PA) to acute pulmonary hypertension induced pharmacologically and by an occlusion maneuver, to study the vascular response of the local segment and its influence in the whole pulmonary circulation. METHODS: Pulmonary pressure and diameter were measured in six anaesthetized sheep under steady-state conditions. Transient hypert...<br/><br/>D Bia, R Armentano, D Craiem, J Grignola, F Ginés, A Simon, J Levenson (2004) <i>Acta Physiol Scand</i> <i></i> <i></i> 181: 3 359-366<br/>

http://publicationslist.org/alain.simon/refid11 2008-02-23T18:06:18Z

cGMP regulates vascular smooth muscle tone and arterial wall response to proliferative signals. We determined plasma cGMP and carotid artery intima-media thickness (IMT) and diameter in 84 asymptomatic men submitted to investigation of their cardiovascular risk profiles. Plasma cGMP was positively associated with IMT (P<0.01) and diameter (P<0.05), independently of coexisting risk factors. These a...<br/><br/>Marie-Aude Devynck, Alain Simon, Marie-Gabrielle Pernollet, Gilles Chironi, Jérôme Gariepy, Francine Rendu, Jaime Levenson (2004) <i>Hypertension</i> <i></i> <i></i> 44: 6 919-923<br/>

http://publicationslist.org/alain.simon/refid279 2007-07-14T07:34:23Z

BACKGROUND AND PURPOSE: Several epidemiological studies have suggested a U-shaped association between alcohol consumption and cardiovascular risk. However, the modifications of vascular structure associated with alcohol consumption are largely unknown. METHODS: The study population sample comprised 6216 subjects (3780 women and 2436 men) aged 65 years or older who were recruited from 3 French citi...<br/><br/>Mahmoud Zureik, Jérôme Gariépy, Dominique Courbon, Jean-François Dartigues, Karen Ritchie, Christophe Tzourio, Annick Alpérovitch, Alain Simon, Pierre Ducimetière (2004) <i>Stroke</i> <i></i> <i></i> 35: 12 2770-2775<br/>

http://publicationslist.org/alain.simon/refid13 2008-02-23T18:06:18Z

BACKGROUND: Calcium antagonists retard progression of intima-media thickness (IMT), but whether this retardation covers heterogeneous individual patient responses of IMT change is unknown. METHODS: Hypertensive patients treated for 4 years with nifedipine (n = 115) or coamilozide (n = 127) underwent ultrasound measurements of carotid IMT at baseline, 4 months later, and then every year. RESULTS: A...<br/><br/>Jerome Gariepy, Alain Simon, Gilles Chironi, Dominique Moyse, Jaime Levenson (2004) <i>J Hypertens</i> <i></i> <i></i> 22: 1 137-143<br/>

http://publicationslist.org/alain.simon/refid15 2008-02-23T18:06:18Z

The authors used ultrasonography to measure carotid artery intima-media thickness (IMT) in 36 HIV-infected patients taking highly active antiretroviral therapy (cases) and in two control groups without (control group 1) or with (control group 2) blood lipid and glucose disturbances similar to those of the patients. Case IMT values were 8% higher than control group 1 IMT values (p <.05) but not dif...<br/><br/>Gilles Chironi, Lelia Escaut, Jerome Gariepy, Anne Cogny, Elina Teicher, Jean-Jacques Monsuez, Jaime Levenson, Alain Simon, Daniel Vittecoq (2003) <i>J Acquir Immune Defic Syndr</i> <i></i> <i></i> 32: 5 490-493<br/>

http://publicationslist.org/alain.simon/refid240 2008-02-23T18:06:18Z

OBJECTIVE: To assess the incidence, clinical features, treatment, and follow-up of coronary events in HIV-infected patients over a period of 5 years. PATIENTS AND PARTICIPANTS: A cohort of 840 patients. MEASUREMENTS AND RESULTS: A coronary event occurred in 17 patients (5.9/1000 persons-years). Sixteen of them were exposed to highly active antiretroviral therapy (HAART). Patients with coronary eve...<br/><br/>Lelia Escaut, Jean Jacques Monsuez, Gilles Chironi, Mansouriah Merad, Elina Teicher, Denis Smadja, Alain Simon, Daniel Vittecoq (2003) <i>Intensive Care Med</i> <i></i> <i></i> 29: 6 969-973<br/>

http://publicationslist.org/alain.simon/refid16 2008-02-23T18:06:18Z

Given the major role of elevated blood pressure in the pathogenesis of both stroke and coronary heart disease, one of the biggest challenges facing public health authorities and medical practitioners is the control of hypertension worldwide, both in individual patients and at the population level. The prevalence of hypertension increases with age and is nearly 60% in people aged 65 - 74 years. Wit...<br/><br/>Alain Simon, Jaime Levenson (2003) <i>Expert Opin Pharmacother</i> <i></i> <i></i> 4: 1 95-106<br/>

http://publicationslist.org/alain.simon/refid238 2008-02-23T18:06:18Z

OBJECTIVES: To assess the incidence and the clinical features of coronary heart disease in HIV-infected patients. To assess atherosclerosis risk factors in this population. METHODS: A review of our experience consisting of 16 patients with acute myocardial infarction (AMI) was the basis of our retrospective analysis of two cohorts in France. Incidence was compared with the national database on the...<br/><br/>Daniel Vittecoq, Lelia Escaut, Gilles Chironi, Elina Teicher, Jean Jacques Monsuez, Michel Andrejak, Alain Simon (2003) <i>AIDS</i> <i></i> <i></i> 17 Suppl 1: S70-S76<br/>

http://publicationslist.org/alain.simon/refid306 2008-02-23T18:06:18Z

Since elevated plasma triglycerides (TGs) are an independent cardiovascular risk factor, we have compared the cholesterol efflux potential of sera from asymptomatic hypertriglyceridemic (HTG) type IIb, type IV or normolipidemic (NLP) individuals using two different cell systems. In both type IIb and IV HTG, the efflux of cholesterol from SR-BI-rich Fu5AH cells was similar to that obtained with NLP...<br/><br/>Natalie Fournier, Omar Francone, George Rothblat, Dominique Goudouneche, Michèle Cambillau, Ginny Kellner-Weibel, Peggy Robinet, Lori Royer, Nicole Moatti, Alain Simon, Jean-Louis Paul (2003) <i>Atherosclerosis</i> <i></i> <i></i> 171: 2 287-293<br/>

http://publicationslist.org/alain.simon/refid14 2008-02-23T18:06:18Z

OBJECTIVE: We aimed to analyze the influence of hypertension on early large artery remodeling. METHODS AND RESULTS: Carotid intima-media thickness (IMT) and diameter were measured ultrasonographically in 394 normotensive subjects and 327 untreated and 528 treated hypertensive patients. IMT and diameter were increased in hypertensive groups, treated or untreated, compared with the normotensive grou...<br/><br/>Gilles Chironi, Jerome Gariepy, Nicolas Denarie, Maria Balice, Jean-Louis Megnien, Jaime Levenson, Alain Simon (2003) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 23: 8 1460-1464<br/>

http://publicationslist.org/alain.simon/refid239 2008-02-23T18:06:18Z

Sterol regulatory element binding proteins (SREBPs) are membrane-bound transcription factors that control the metabolism of cholesterol and fatty acids in mammalian cells. We postulated that polymorphisms (SNPs) in SREBP-2 gene might influence lipid parameters and the risk of coronary atherosclerosis. PCR-SSCP analysis and direct sequencing of DNA from 64 asymptomatic hypercholesterolemic men reve...<br/><br/>Peggy Robinet, Benoit Védie, Gilles Chironi, Jérôme Gariépy, Alain Simon, Nicole Moatti, Jean Louis Paul (2003) <i>Atherosclerosis</i> <i></i> <i></i> 168: 2 381-387<br/>

http://publicationslist.org/alain.simon/refid18 2008-02-23T18:06:18Z

Atherosclerotic disease is the most frequent cause of death in the western world.The key role of calcium ions in atherogenesis has created interest in the antiatherogenic potential of calcium channel blockers. Nifedipine, administered in a long-acting gastrointestinal transport system (GITS) formulation, was shown to have similar efficacy to the diuretic co-amilozide in the International Nifedipin...<br/><br/>Alain Simon, Jaime Levenson (2002) <i>Acta Cardiol</i> <i></i> <i></i> 57: 4 249-255<br/>

http://publicationslist.org/alain.simon/refid20 2008-02-23T18:06:18Z

The role of blood viscosity on arterial wall elasticity before and after deendothelization (DE) was studied. Seven ovine brachiocephalic arteries were studied in vitro under physiological pulsatile flow conditions achieved by a mock circulation loop. Instantaneous pressure and diameter signals were assessed in each arterial segment. Incremental elastic modulus (E(inc)) was calculated using the slo...<br/><br/>Edmundo I Cabrera Fischer, Ricardo L Armentano, Franco M Pessana, Sebastián Graf, Luis Romero, Alejandra I Christen, Alain Simon, Jaime Levenson (2002) <i>Am J Physiol Heart Circ Physiol</i> <i></i> <i></i> 282: 2 H389-H394<br/>

http://publicationslist.org/alain.simon/refid17 2008-02-23T18:06:18Z

Extended coronary artery calcifications (CAC) are predictive for cardiovascular complications but little is known about factors likely to influence CAC deposit. An analysis was undertaken to assess the cardiovascular risk factors that are capable of predicting CAC change over time. A retrospective analysis of CAC change was carried out in 55 asymptomatic men who underwent sequential electron beam ...<br/><br/>Gilles Chironi, Alain Simon, Nicolas Denarié, Benoit Védie, Valérie Séné, Jean-Louis Mégnien, Jaime Levenson (2002) <i>Angiology</i> <i></i> <i></i> 53: 6 677-683<br/>

http://publicationslist.org/alain.simon/refid19 2008-02-23T18:06:18Z

Increased intima-media thickness (IMT) is a non-invasive marker of early arterial wall alteration, which is easily assessed in the carotid artery by B-mode ultrasound, and more and more widely used in clinical research. Methods of IMT measurement can be categorized by two approaches: (i) measurement at multiple extracranial carotid sites in near and far walls and (ii) computerized measurement rest...<br/><br/>Alain Simon, Jérôme Gariepy, Gilles Chironi, Jean-Louis Megnien, Jaime Levenson (2002) <i>J Hypertens</i> <i></i> <i></i> 20: 2 159-169<br/>

http://publicationslist.org/alain.simon/refid23 2008-02-23T18:06:18Z

BACKGROUND AND PURPOSE: We attempted to detect a group-specific north-south difference in carotid artery intima-media thickness (IMT), a marker of subsequent cardiovascular complication, by means of a case (high risk)-control (low risk) study in French and Swedish men. METHODS: The selection of high-risk and low-risk subjects was performed within the lower and upper percentiles of the Framingham r...<br/><br/>N Denarié, A Simon, G Chironi, J Gariepy, L Kumlin, M Massonneau, C Lanoiselée, L Dimberg, J Levenson (2001) <i>Stroke</i> <i></i> <i></i> 32: 8 1775-1779<br/>

http://publicationslist.org/alain.simon/refid22 2008-02-23T18:06:18Z

Effects of antihypertensive treatment on large arteries may be influenced by the type of drug and concomitant risk factors such as blood cholesterol. To explore these possibilities we investigated the common carotid artery of 20 subjects with low cholesterol and 19 subjects with high cholesterol, all with essential hypertension, randomly allocated to 3 months of treatment with nitrendipine (20 mg/...<br/><br/>J L Megnien, A Simon, E Mikaberidze, N Denarie, G Chironi, J Barra, R Armentano, J Levenson (2001) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 38: 4 520-528<br/>

http://publicationslist.org/alain.simon/refid24 2008-02-23T18:06:18Z

Viscoelastic properties determine the dynamic behaviour of the arterial wall under pulsatile pressure and flow, suggesting time- or frequency-dependent responses to changes in wall stress and strain. The objectives of the present study were: (i) to develop a simplified model to derive simultaneously the elastic, viscous and inertial wall moduli; (ii) to assess Young's modulus as a function of freq...<br/><br/>L G Gamero, R L Armentano, J G Barra, A Simon, J Levenson (2001) <i>Exp Physiol</i> <i></i> <i></i> 86: 4 519-528<br/>

http://publicationslist.org/alain.simon/refid25 2008-02-23T18:06:18Z

BACKGROUND: Common carotid artery intima-media thickness (IMT) progression was compared between 4 years of treatment with nifedipine and diuretic. METHODS AND RESULTS: This study, ancillary to the International Nifedipine GITS Study: Intervention as a Goal in Hypertension Treatment (INSIGHT), involved nifedipine 30 mg or co-amilozide (hydrochlorothiazide 25 mg and amiloride 2.5 mg) with optional s...<br/><br/>A Simon, J Gariépy, D Moyse, J Levenson (2001) <i>Circulation</i> <i></i> <i></i> 103: 24 2949-2954<br/>

http://publicationslist.org/alain.simon/refid26 2008-02-23T18:06:18Z

Two traditional methodologic approaches, the analysis of the arterial pressure waveform in the time domain and the measurement of pulse wave velocity along the arterial tree, have been extensively used to determine the distensibility of large arteries in humans. They have shown that large artery walls are stiffened in the presence of hypertension. However, several methodologic limitations, especia...<br/><br/>A Simon, J Levenson (2001) <i>Curr Hypertens Rep</i> <i></i> <i></i> 3: 1 74-79<br/>

http://publicationslist.org/alain.simon/refid21 2008-02-23T18:06:18Z

OBJECTIVES: We sought to investigate wall shear rate (WSR) and brachial artery diameter (BAD) changes simultaneously and to determine whether any gender differences exist in arterial reactivity. BACKGROUND: Wall shear rate/stress and arterial reactivity are rarely assessed at the same time. Furthermore, flow-mediated vasoconstriction has received less attention than flow-mediated vasodilation in h...<br/><br/>J Levenson, F Pessana, J Gariepy, R Armentano, A Simon (2001) <i>J Am Coll Cardiol</i> <i></i> <i></i> 38: 6 1668-1674<br/>

http://publicationslist.org/alain.simon/refid310 2008-02-23T18:06:18Z

The high triglyceride/low HDL-cholesterol trait is a common finding in the general population. The aim of the present study was to analyze and interpret the relationships between triglycerides (TG), HDL-related parameters and serum cholesterol efflux potential in an asymptomatic population including both normo- and hyperlipidemic individuals. In a large sample (n = 1143) of this population, there ...<br/><br/>N Fournier, V Atger, A Cogny, B Vedie, P Giral, A Simon, N Moatti, J L Paul (2001) <i>Atherosclerosis</i> <i></i> <i></i> 157: 2 315-323<br/>

http://publicationslist.org/alain.simon/refid281 2007-07-14T07:34:23Z

BACKGROUND: Haemochromatosis is a common genetic disorder, inherited as an autosomal recessive trait that results in a progressive accumulation of iron in most tissues of the body. Positive association studies have been recently published between cardiovascular diseases and heterozygosity for the major mutation C282Y in the haemochromatosis gene HFE. METHODS: In the present work, we have determine...<br/><br/>G Hetet, A Elbaz, J Gariepy, V Nicaud, D Arveiler, C Morrison, F Kee, A Evans, A Simon, P Amarenco, F Cambien, B Grandchamp (2001) <i>Eur J Clin Invest</i> <i></i> <i></i> 31: 5 382-388<br/>

http://publicationslist.org/alain.simon/refid280 2008-02-23T18:06:18Z

Epidemiological data regarding the preventive role of vitamin E in the pathogenesis of atherosclerosis have yielded conflicting results, possibly because endpoints considered were clinical events but not detection of atherosclerosis per se. Otherwise, it has been suggested that the measure of the erythrocyte alpha-tocopherol level may be more suitable to assess the human tocopherol status than its...<br/><br/>E Simon, J Gariepy, A Cogny, N Moatti, A Simon, J L Paul (2001) <i>Atherosclerosis</i> <i></i> <i></i> 159: 1 193-200<br/>

http://publicationslist.org/alain.simon/refid283 2008-02-23T18:06:18Z

Sterol-regulatory element binding proteins (SREBPs) are ubiquitous transcription factors that regulate the genes encoding key proteins in the control of cholesterol homeostasis. We looked for mutations or polymorphisms within the sequences of the SREBP-1a gene critical for the synthesis and/or activity of the protein in 204 asymptomatic men. A single G deletion at base pair -36 of the translation ...<br/><br/>B Védie, X Jeunemaitre, J L Mégnien, V Atger, A Simon, N Moatti (2001) <i>Atherosclerosis</i> <i></i> <i></i> 154: 3 589-597<br/>

http://publicationslist.org/alain.simon/refid32 2008-02-23T18:06:18Z

Our objective was to provide a description of 'normal' carotid artery dimensions which are increasingly used for detecting early atherosclerosis and predicting clinical complications. Far wall intima-media thickness (IMT), lumen diameter and cross-sectional area intima-media thickness (CSA-IMT) were measured on 1 cm-distal common carotid artery segments on both sides by B-mode ultrasound, using an...<br/><br/>N Denarié, J Gariepy, G Chironi, M Massonneau, F Laskri, J Salomon, J Levenson, A Simon (2000) <i>Atherosclerosis</i> <i></i> <i></i> 148: 2 297-302<br/>

http://publicationslist.org/alain.simon/refid30 2008-02-23T18:06:18Z

Despite its potential usefulness for assessing preclinical atherosclerosis and cardiovascular risk, the ankle/arm blood pressure index (AAI) has not yet been the matter of study evaluating its feasibility and reliability by nonspecialist doctors in a general population. This study was planned for two steps. In step 1, the measurement of AAI, (ratio between Doppler systolic pressure at the ankle fo...<br/><br/>A Simon, L Papoz, A Ponton, P Segond, F Becker, L Drouet, J Levenson, M Marazanof, Y Sentou, E Chollet, J Etiemble (2000) <i>Angiology</i> <i></i> <i></i> 51: 6 463-471<br/>

http://publicationslist.org/alain.simon/refid29 2008-02-23T18:06:18Z

Plasma viscosity and intima-media thickness (IMT) are frequently associated with cardiovascular disease and its risk factors. We evaluated the association of rheologic and vascular factors in asymptomatic subjects. Plasma viscosity (coaxial cylinder viscometry) and both preintrusive and intrusive atherosclerosis in the carotid arteries (ultrasonography) were investigated in 246 men and 337 women a...<br/><br/>J Levenson, J Gariepy, M Del-Pino, J Salomon, N Denarie, A Simon (2000) <i>Am J Hypertens</i> <i></i> <i></i> 13: 7 753-758<br/>

http://publicationslist.org/alain.simon/refid28 2008-02-23T18:06:18Z

BACKGROUND: We hypothesized that arterial wall thickening, an early atherogenic alteration, might be associated with smoking differently according to gender, considering the cardiovascular protection of female sex hormones. METHODS AND RESULTS: We measured ultrasonographically carotid and femoral intima-media thickness (IMT) in 194 men and 330 women without risk factors other than smoking. In men:...<br/><br/>J Gariepy, N Denarie, G Chironi, J Salomon, J Levenson, A Simon (2000) <i>Atherosclerosis</i> <i></i> <i></i> 153: 1 139-145<br/>

http://publicationslist.org/alain.simon/refid27 2008-02-23T18:06:18Z

The vascular endothelium and circulating blood cells are exposed to a hemodynamic environment related to the pulsatile nature of the pressure and blood flow which influence the morphology, the physical properties and the metabolism of the cells. Among these mechanical forces, shear stresses, related to the speed gradients and to the blood viscosity, control vascular vasomotor tone and thrombogenec...<br/><br/>J Levenson, M Del-Pino, A Simon (2000) <i>J Mal Vasc</i> <i></i> <i></i> 25: 4 237-240<br/>

http://publicationslist.org/alain.simon/refid282 2007-07-14T07:34:23Z

The matrix Gla protein (MGP) is an important inhibitor of vessel and cartilage calcification that is strongly expressed in human calcified, atherosclerotic plaques and could modulate plaque calcification and coronary heart disease risk. Using a genetic approach, we explored this possibility by identifying polymorphisms of the MGP gene and testing their possible association with myocardial infarcti...<br/><br/>S M Herrmann, C Whatling, E Brand, V Nicaud, J Gariepy, A Simon, A Evans, J B Ruidavets, D Arveiler, G Luc, L Tiret, A Henney, F Cambien (2000) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 20: 11 2386-2393<br/>

http://publicationslist.org/alain.simon/refid311 2008-02-23T18:06:18Z

We previously showed that hypercholesterolemic asymptomatic men had lower erythrocyte vitamin E content, despite normal plasma concentrations compared to normocholesterolemic men. We hypothesized that the reduced erythrocyte vitamin E concentration could be due to an impairment of transfer of vitamin E from plasma lipoproteins. We first developed a model for testing the ability of erythrocytes to ...<br/><br/>E Simon, J L Paul, V Atger, A Simon, N Moatti (2000) <i>Free Radic Biol Med</i> <i></i> <i></i> 28: 5 815-823<br/>

http://publicationslist.org/alain.simon/refid37 2008-02-23T18:06:18Z

BACKGROUND: A central distribution of adipose tissue is frequently associated with cardiovascular disease (CVD) and its risk factors. METHODS: Clinical usefulness of waist-to-hip ratio (WHR) for predicting the risk of cardiovascular events, estimated with models based on data from the Framingham and Prospective Cardiovascular Münster (PROCAM) studies was evaluated. SUBJECTS: These were 552 men an...<br/><br/>J L Megnien, N Denarie, M Cocaul, A Simon, J Levenson (1999) <i>Int J Obes Relat Metab Disord</i> <i></i> <i></i> 23: 1 90-97<br/>

http://publicationslist.org/alain.simon/refid36 2008-02-23T18:06:18Z

Shear forces induce platelet aggregation and stimulate the endothelial production of anti-aggregatory factors. Among them, endothelin-3 (ET-3) has been reported to reduce aggregation and to increase platelet cyclic GMP (cGMP) content. Since hypercholesterolemia modifies both platelet aggregability and endothelial function, we compared in 14 hypercholesterolemic and 15 normocholesterolemic subjects...<br/><br/>C Gagnet, M A Devynck, A Simon, J Levenson (1999) <i>Atherosclerosis</i> <i></i> <i></i> 143: 1 91-97<br/>

http://publicationslist.org/alain.simon/refid33 2008-02-23T18:06:18Z

A new automated computerized system (IôTEC) that assesses concomitantly the instantaneous temporal arterial diameter and intimal media thickness (IMT) obtained from B-mode ultrasound (US) images was validated by sonomicrometry in sheep, by an echo-tracking system in humans, and by a Lucite phantom in vitro. Differences between methods for diameter measurements did not vary in any systematic way, ...<br/><br/>S Graf, J Gariepy, M Massonneau, R L Armentano, S Mansour, J G Barra, A Simon, J Levenson (1999) <i>Ultrasound Med Biol</i> <i></i> <i></i> 25: 9 1353-1363<br/>

http://publicationslist.org/alain.simon/refid34 2008-02-23T18:06:18Z

A Simon, J Gariepy, J Levenson (1999) <i>Presse Med</i> <i></i> <i></i> 28: 19 1021-1022<br/>

http://publicationslist.org/alain.simon/refid31 2008-02-23T18:06:18Z

OBJECTIVE: The aim of this study is to evaluate the relationship between carotid intima-media thickness (IMT) and arterial wall inertial behaviour. METHODS: The simultaneous and noninvasive assessment of the intima-media complex and arterial diameter waveform was performed using high-resolution ultrasonography. The common carotid artery of eleven normotensive subjects (NTA) and eleven mild-to-mode...<br/><br/>L Gamero, J Levenson, R Armentano, S Graf, L Brandani, A Simon, H Baglivo, R Sánchez (1999) <i>J Hypertens</i> <i></i> <i></i> 17: 12 Pt 2 1825-1829<br/>

http://publicationslist.org/alain.simon/refid286 2007-07-14T07:38:51Z

Several markers of preclinical atherosclerosis are currently available, such as: wall thickening and stiffening and endothelial dysfunction of large peripheral arteries detected by ultrasonography, or coronary calcification detected by ultrafast computed tomography. They reflect the integrated effects over time of multiple risk factors, traditional and emerging, and some of them (wall thickening a...<br/><br/>A Simon (1999) <i>Rev Prat</i> <i></i> <i></i> 49: 19 2104-2109<br/>

http://publicationslist.org/alain.simon/refid44 2008-02-23T18:06:18Z

Previous reports have investigated associations between carotid intima-media thickness (IMT) and cardiovascular risk factors. Our objective was to investigate this question in greater depth by measuring both femoral and carotid IMT in relation to sex and multifactorial coronary risk. We investigated carotid and femoral artery IMT by using ultrasonography in 326 men and 462 women, 17 to 65 years ol...<br/><br/>J Gariepy, J Salomon, N Denarié, F Laskri, J L Mégnien, J Levenson, A Simon (1998) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 18: 4 584-590<br/>

http://publicationslist.org/alain.simon/refid43 2008-02-23T18:06:18Z

J Levenson, A Simon (1998) <i>Am J Cardiol</i> <i></i> <i></i> 81: 8A 67F-68F<br/>

http://publicationslist.org/alain.simon/refid45 2008-02-23T18:06:18Z

Stiffness of aortic walls has been shown to be a marker of coronary and cerebrovascular diseases in patients with myocardial infarction or stroke. However, its value for predicting preclinical atherosclerosis has not been demonstrated. Therefore, this study tested the association of aortic wall stiffness and coronary and extracoronary atherosclerosis in the absence of clinical cardiovascular disea...<br/><br/>J L Megnien, A Simon, N Denarie, M Del-Pino, J Gariepy, P Segond, J Levenson (1998) <i>Am J Hypertens</i> <i></i> <i></i> 11: 3 Pt 1 293-301<br/>

http://publicationslist.org/alain.simon/refid46 2008-02-23T18:06:18Z

BACKGROUND: Carotid artery structure change was associated with coronary artery stenosis by angiography of subjects who were for the most part symptomatic. OBJECTIVE: To determine whether structural changes at multiple extracoronary sites were associated with noninvasively detected coronary calcium for 94 asymptomatic high-risk men. METHODS AND RESULTS: B-mode ultrasonography allowed us to detect ...<br/><br/>J L Megnien, A Simon, J Gariepy, N Denarie, M Cocaul, A Linhart, J Levenson (1998) <i>J Hypertens</i> <i></i> <i></i> 16: 2 157-163<br/>

http://publicationslist.org/alain.simon/refid42 2008-02-23T18:06:18Z

The objective of this study was to test the value of electrocardiogram for predicting left ventricular mass (LVM), assessed echographically in 136 asymptomatic men with at least one major cardiovascular risk factor. We measured the Sokolow-Lyon and Cornell voltages, as well as the ratio of Cornell voltage to QRS voltage in lead II. The prevalence of left ventricular hypertrophy (LVH), defined as L...<br/><br/>N Denarié, A Linhart, J Levenson, A Simon (1998) <i>Am J Hypertens</i> <i></i> <i></i> 11: 7 861-865<br/>

http://publicationslist.org/alain.simon/refid48 2008-02-23T18:06:18Z

Increases in arterial wall viscosity and intima-media thickness (IMT) were found in hypertensive patients. Because smooth muscle cells are responsible for the viscous behavior of the arterial wall and they are involved in the process of thickening of the intima-media complex, this study evaluates the relationship between carotid thickness and wall viscosity. The simultaneous and noninvasive assess...<br/><br/>R L Armentano, S Graf, J G Barra, G Velikovsky, H Baglivo, R Sánchez, A Simon, R H Pichel, J Levenson (1998) <i>Hypertension</i> <i></i> <i></i> 31: 1 Pt 2 534-539<br/>

http://publicationslist.org/alain.simon/refid40 2008-02-23T18:06:18Z

A Simon, J Levenson (1998) <i>Lancet</i> <i></i> <i></i> 352: 9127 571; author reply 574-571; author reply 575<br/>

http://publicationslist.org/alain.simon/refid285 2008-02-23T18:06:18Z

This study was carried out to examine the relationship between the charge on low density lipoproteins (LDLs) and lipid and clinical parameters in 104 asymptomatic dyslipidemic men and to identify biochemical and genetic factors that could contribute to the charge variability of LDL. LDL charge heterogeneity was evaluated by relative electrophoretic mobility (REM) on preformed 0.5% agarose gels and...<br/><br/>B Védie, X Jeunemaitre, J L Mégnien, I Myara, H Trébeden, A Simon, N Moatti (1998) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 18: 11 1780-1789<br/>

http://publicationslist.org/alain.simon/refid41 2008-02-23T18:06:18Z

The detection of preclinical atherosclerosis may contribute to better identifying hypertensive subjects at high risk of complications. Three alterations can be diagnosed noninvasively: calcification, thickening, and stiffening of the arterial wall. Their prevalence is increased in asymptomatic hypertensives and their presence may have important prognostic significance, especially with respect to c...<br/><br/>A Simon, J L Megnien, J Gariepy, J Levenson (1998) <i>Am J Hypertens</i> <i></i> <i></i> 11: 7 882-883<br/>

http://publicationslist.org/alain.simon/refid284 2008-02-23T18:06:18Z

FUNDAMENTAL PRINCIPLES: Therapeutic management of hypercholesterolemia requires information on two fundamental aspects: the patient's lipid profile and his/her risk of coronary artery disease. RISK EVALUATION: The latest therapeutic trials have partially confirmed the LDL-cholesterol levels retained for the different guidelines, including those proposed by the ANDEM. It is clear however, that the ...<br/><br/>J L Mégnien, A Simon (1998) <i>Presse Med</i> <i></i> <i></i> 27: 39 2056-2061<br/>

http://publicationslist.org/alain.simon/refid35 2008-02-23T18:06:18Z

BACKGROUND AND AIMS: One-third of acromegalic patients have hypertension. Acromegaly is also associated with intrinsic cardiac abnormalities known collectively as a hyperkinetic heart syndrome, which is characterized by an increased cardiac index and decreased systemic vascular resistance. As a result, blood flow should be increased in the regional vascular beds of acromegalic patients. The aim of...<br/><br/>P Chanson, J L Megnien, M del Pino, C Coirault, I Merli, L Houdouin, A G Harris, J Levenson, Y Lecarpentier, A Simon, D Chemla (1998) <i>Clin Endocrinol (Oxf)</i> <i></i> <i></i> 49: 6 725-731<br/>

http://publicationslist.org/alain.simon/refid312 2008-02-23T18:06:18Z

An imbalance between antioxidant and oxidant-generating systems leading to an oxidative stress has already been proposed in the pathogenesis of atherosclerosis. In the present study we investigated the antioxidant status in 60 asymptomatic hypercholesterolemic (HC) men compared with 48 normocholesterolemic (NC) men. Hypercholesterolemic subjects had a significantly lower red blood cell vitamin E (...<br/><br/>E Simon, J L Paul, V Atger, A Simon, N Moatti (1998) <i>Atherosclerosis</i> <i></i> <i></i> 138: 2 375-381<br/>

http://publicationslist.org/alain.simon/refid38 2008-02-23T18:06:18Z

BACKGROUND: We aimed to determine whether intima-media thickness (IMT) was increased in the carotid artery of subjects with homocystinuria to better understand the in vivo contribution of homocysteine to early atherogenesis. METHODS AND RESULTS: We investigated ultrasonographically the right common carotid artery in 14 subjects with homozygous homocystinuria aged 3 to 34 years (mean, 13 years) and...<br/><br/>J L Megnien, J Gariepy, J M Saudubray, J M Nuoffer, N Denarie, J Levenson, A Simon (1998) <i>Circulation</i> <i></i> <i></i> 98: 21 2276-2281<br/>

http://publicationslist.org/alain.simon/refid39 2008-02-23T18:06:18Z

Erythrocyte aggregation, which plays an important role in the physiological behavior of blood fluidity, was found to be enhanced in hypertension and hypercholesterolemia. While the role of macromolecule bridging force has been widely described, cellular factors related to membrane sialic acid content, which might contribute to the negative charge of cell surface causing the repulsion of erythrocyt...<br/><br/>A L Hadengue, M Del-Pino, A Simon, J Levenson (1998) <i>Hypertension</i> <i></i> <i></i> 32: 2 324-330<br/>

http://publicationslist.org/alain.simon/refid50 2008-02-23T18:06:18Z

Because of the limited ability of blood pressure elevation to predict risk, the mass drug treatment of hypertension above an arbitrary threshold may result in many subjects being overtreated. One potential way to overcome this problem is to noninvasively detect preclinical atherosclerosis. Hypertension has been shown to be associated with 1) increased intima-media thickness and more frequent plaqu...<br/><br/>A Simon, J L Megnien, J Levenson (1997) <i>Am J Hypertens</i> <i></i> <i></i> 10: 7 Pt 1 813-824<br/>

http://publicationslist.org/alain.simon/refid51 2008-02-23T18:06:18Z

Ultrasonography of the arterial wall allows detection of structural (thickening, plaque) and/or functional (rigidity, reactivity) changes associated with preclinical atherosclerosis. Thickening of the arterial wall may be observed by measuring the intima-media thickness of the posterior wall of the common carotid or superficial femoral arteries. Hypertension, hypercholesterolaemia, diabetes and ci...<br/><br/>A Simon, J Gariepy, J Levenson (1997) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 90 Spec No 2: 7-10<br/>

http://publicationslist.org/alain.simon/refid49 2008-02-23T18:06:18Z

BACKGROUND: Evidence-based treatment of hypercholesterolemia currently recommended for rationalizing drug prescription requires justification of treatment by randomized trials, such as the West of Scotland Coronary Prevention Study (WOSCOPS) or the Scandinavian Simvastatin Survival Study (4S), and evaluation of its benefit from the estimation of the coronary risk of each patient. METHODS AND RESUL...<br/><br/>A Simon, J L Megnien, J Levenson (1997) <i>Circulation</i> <i></i> <i></i> 96: 7 2449-2452<br/>

http://publicationslist.org/alain.simon/refid52 2008-02-23T18:06:18Z

The influence of the renin-angiotensin system (RAS) on the aortic wall mechanical properties under angiotensin I converting enzyme inhibition (enalaprilat, 0.3 mg/kg iv) or angiotensin II receptor (AT1) blockade (E-3174, 1 mg/kg iv) was examined in eight normotensive and eight renovascular hypertensive conscious dogs. Aortic diameter (D; sonomicrometry)-pressure (P; microtransducer) hysteresis loo...<br/><br/>J G Barra, J Levenson, R L Armentano, E I Cabrera Fischer, R H Pichel, A Simon (1997) <i>Am J Physiol</i> <i></i> <i></i> 272: 2 Pt 2 H859-H868<br/>

http://publicationslist.org/alain.simon/refid53 2008-02-23T18:06:18Z

The association between plasma fibrinogen and the presence of carotid, femoral, and aortic plaque (high-resolution B-mode ultrasonography) and coronary calcium deposit (ultrafast computed tomography scanner) was determined in 693 hypercholesterolemic, never-treated men free of previous or current clinical symptoms of cardiovascular disease. The number of subjects with extracoronary disease sites a...<br/><br/>J Levenson, P Giral, J L Megnien, J Gariepy, M C Plainfosse, A Simon (1997) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 17: 1 45-50<br/>

http://publicationslist.org/alain.simon/refid288 2008-02-23T18:06:18Z

The present study was designed to assess plasma and erythrocyte vitamin E concentrations in 57 asymptomatic hypercholesterolemic (HC) men compared with 56 normocholesterolemic (NC) men. Vitamin E concentrations were determined by using a reversed-phase HPLC method. Compared with NC subjects, HC men had a significantly lower red blood cell (RBC) vitamin E content in spite of their normal plasma vit...<br/><br/>E Simon, J L Paul, T Soni, A Simon, N Moatti (1997) <i>Clin Chem</i> <i></i> <i></i> 43: 2 285-289<br/>

http://publicationslist.org/alain.simon/refid47 2008-02-23T18:06:18Z

To determine whether or not the lower rate of coronary disease in France, in comparison with Sweden, might be explained by different cardiovascular risk profiles, a cross-sectional analysis (first step of a longitudinal study) of comparable samples of automotive workers was carried out in corporate occupational health clinics of Renault and Volvo. Traditional cardiovascular risk factors were evalu...<br/><br/>A Simon, L Dimberg, J Levenson, C Lanoiselée, M Massonneau, B Eriksson, S Jern, L Kumlin, P Marin, B Dahlöf, L Hansson, P Björntorp (1997) <i>Eur J Epidemiol</i> <i></i> <i></i> 13: 8 885-891<br/>

http://publicationslist.org/alain.simon/refid287 2007-07-14T07:38:51Z

The detection of early atherosclerosis, accelerated by the presence of diabetes mellitus, is of major importance for improving the prediction and the prevention of subsequent clinical events. Three markers of atherosclerosis can be detected non invasively: arterial wall thickening, coronary calcification and arterial wall stiffening. Intima-media thickness can be measured by B-mode ultrasonography...<br/><br/>A Simon (1997) <i>Therapie</i> <i></i> <i></i> 52: 5 423-428<br/>

http://publicationslist.org/alain.simon/refid58 2008-02-23T18:06:18Z

Despite its important role in coronary disease, coronary atherosclerosis has been poorly investigated in uncomplicated hypertension. Therefore, we evaluated the presence and amount (score) of coronary calcium with ultrafast computed tomography in 73 pairs of age-matched asymptomatic hypertensive or normotensive men. We also estimated the extent of peripheral atherosclerosis as the number of arteri...<br/><br/>J L Megnien, A Simon, M Lemariey, M C Plainfossé, J Levenson (1996) <i>Hypertension</i> <i></i> <i></i> 27: 4 949-954<br/>

http://publicationslist.org/alain.simon/refid59 2008-02-23T18:06:18Z

J L Megnien, J Levenson, A Simon (1996) <i>Lancet</i> <i></i> <i></i> 347: 8999 468; author reply 468-468; author reply 469<br/>

http://publicationslist.org/alain.simon/refid61 2008-02-23T18:06:18Z

Extracoronary in vivo structural arterial changes were studied in asymptomatic essential hypertension. Carotid and femoral arteries were examined with B-mode echography for the presence or absence of plaque (the whole vascular segments of each vessel in the both sides) and for automated measurement of the far wall intima-media thickness (the vascular segment of each vessel proximal to the bifurcat...<br/><br/>J Gariepy, A Simon, M Massonneau, A Linhart, P Segond, J Levenson (1996) <i>Am J Hypertens</i> <i></i> <i></i> 9: 2 126-136<br/>

http://publicationslist.org/alain.simon/refid60 2008-02-23T18:06:18Z

OBJECTIVES: Hyperlipidemia is a feature of liver glycogen storage disease (GSD). Recent studies have suggested that rheological mechanisms such as elevated erythrocyte aggregation may be involved in the pathogenesis of ischemic syndromes associated with hyperlipidemia. DESIGN AND METHODS: We investigated erythrocyte aggregation, lipids, and circulatory proteins in the blood of 24 patients affected...<br/><br/>K Keddad, S M Razavian, C Baussan, J Chalas, A Abella, J Levenson, A Simon, N Moatti, A Legrand (1996) <i>Clin Biochem</i> <i></i> <i></i> 29: 1 73-78<br/>

http://publicationslist.org/alain.simon/refid57 2008-02-23T18:06:18Z

Liver glycogen storage diseases (GSD) are disorders associated with severe dyslipidaemia which can induce cell membrane alterations and possibly reduced cell deformability. Since decreased erythrocyte deformability is known to disturb blood flow in capillaries and may promote ischaemic diseases, this study was designed to investigate erythrocyte deformability using a new filtration system, the Cel...<br/><br/>K Keddad, S M Razavian, C Baussan, A Abella, J Chalas, J Levenson, A Simon, N Moatti, A Legrand (1996) <i>Thromb Res</i> <i></i> <i></i> 82: 2 159-168<br/>

http://publicationslist.org/alain.simon/refid56 2008-02-23T18:06:18Z

1. We tested whether lipid lowering treatment with HMG CoA reductase inhibitor modified the flow mediated large artery reactivity in primary pure hypercholesterolaemia. 2. Abnormalities in arterial reactivity have been described in the presence of high blood cholesterol, in particular an enhanced constriction of the brachial artery in response to acute induction of a low flow state. 3. Using pulse...<br/><br/>J L Megnien, A Simon, A Andriani, P Segond, S Jeannin, J Levenson (1996) <i>Br J Clin Pharmacol</i> <i></i> <i></i> 42: 2 187-193<br/>

http://publicationslist.org/alain.simon/refid54 2008-02-23T18:06:18Z

The respective role of adhesive forces induced by fibrinogen and repulsive forces induced by erythrocyte sialic acid content on erythrocyte aggregation, was investigated in hypercholesterolemic and control subjects. Aggregation index (AI) and disaggregation shear rate threshold (gamma t) were determined in the presence of either autologous plasma or dextran. Compared with controls, fibrinogen (p <...<br/><br/>A Hadengue, S M Razavian, M Del-Pino, A Simon, J Levenson (1996) <i>Thromb Haemost</i> <i></i> <i></i> 76: 6 944-949<br/>

http://publicationslist.org/alain.simon/refid55 2008-02-23T18:06:18Z

To determine whether a relationship between echographically assessed carotid artery and left ventricular (LV) structures existed in asymptomatic men at risk for cardiovascular disease, we evaluated carotid and LV parameters in 69 subjects (23-62 years) without LV hypertrophy. The right common carotid far wall intima-media thickness (IMT) was measured using an automated technique and the cross-sect...<br/><br/>A Linhart, J Gariepy, P Giral, J Levenson, A Simon (1996) <i>Atherosclerosis</i> <i></i> <i></i> 127: 1 103-112<br/>

http://publicationslist.org/alain.simon/refid70 2008-02-23T18:06:18Z

1. The objectives of this study were to study the flow-dependent arterial reactivity and pressure-independent arterial compliance of the calcium antagonist amlodipine in hypertensive men. 2. Twenty-one hypertensive patients were randomized to receive 2 months treatment with placebo (n = 10) or 5-10 mg amlodipine (n = 11) once a day. Non-invasive measurement of brachial artery mean blood pressure, ...<br/><br/>J L Megnien, J Levenson, M Del-Pino, A Simon (1995) <i>Br J Clin Pharmacol</i> <i></i> <i></i> 39: 6 641-649<br/>

http://publicationslist.org/alain.simon/refid69 2008-02-23T18:06:18Z

This study was designed to evaluate the relationships between platelet cytosolic Ca2+ concentration ([Ca2+]i) and plasma lipids in patients with primary hypercholesterolemia. In a double-blind, placebo-controlled trial, we determined platelet [Ca2+]i in the presence and virtual absence of extracellular Ca2+ and the effects of prolonged treatment with pravastatin, a selective inhibitor of 3-hydroxy...<br/><br/>K H Le Quan Sang, J Levenson, J L Megnien, A Simon, M A Devynck (1995) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 15: 6 759-764<br/>

http://publicationslist.org/alain.simon/refid71 2008-02-23T18:06:18Z

Elevated concentration of plasma homocyst(e)ine is an independent risk factor for clinical atherosclerosis. In this study, the concentration of plasma homocyst(e)ine in men who lacked a history of atherosclerotic disease was correlated with hemodynamic, rheological and biochemical parameters. Hypertensive subjects had higher concentrations of plasma homocyst(e)ine than normotensive subjects. Posit...<br/><br/>M R Malinow, J Levenson, P Giral, F J Nieto, M Razavian, P Segond, A Simon (1995) <i>Atherosclerosis</i> <i></i> <i></i> 114: 2 175-183<br/>

http://publicationslist.org/alain.simon/refid73 2008-02-23T18:06:18Z

Recent studies have shown that the sialic acid content of LDL isolated from patients with angiographically demonstrated advanced coronary atherosclerosis is lower than that of LDL isolated from healthy subjects. These observations raise the question as to whether LDL sialic acid content could be used as an early marker of atherosclerosis. We screened for carotid, aortic, and femoral plaques by ult...<br/><br/>B Chappey, I Myara, P Giral, G Kerharo, M C Plainfosse, J Levenson, A Simon, N Moatti (1995) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 15: 3 334-339<br/>

http://publicationslist.org/alain.simon/refid75 2008-02-23T18:06:18Z

Although the inverse relation between high-density lipoprotein (HDL) cholesterol concentration and the risk of ischemic heart disease is well established, little is known about the relation of HDL subfractions HDL2 and HDL3 or lipoprotein A-I and A-I-A-II to extracoronary disease, particularly at its silent phase before the appearance of clinical lesions. We investigated the potential influence of...<br/><br/>V Atger, P Giral, A Simon, M Cambillau, J Levenson, J Gariepy, J L Megnien, N Moatti (1995) <i>Am J Cardiol</i> <i></i> <i></i> 75: 2 127-131<br/>

http://publicationslist.org/alain.simon/refid74 2008-02-23T18:06:18Z

This study was performed to determine whether hypercholesterolemic men had increased large artery intima-media thickness (IMT), a potential surrogate measure of atherosclerosis, compared to normocholesterolemic controls. The measurements were performed in the far walls of common carotid and femoral arteries with non-invasive automatic computerized ultrasonic technique in 101 asymptomatic men (28-6...<br/><br/>J Gariepy, A Simon, M Massonneau, A Linhart, J Levenson (1995) <i>Atherosclerosis</i> <i></i> <i></i> 113: 2 141-151<br/>

http://publicationslist.org/alain.simon/refid68 2008-02-23T18:06:18Z

We compared the properties of common carotid and femoral arteries of 16 normotensive and 14 hypertensive men. Arterial pressure and diameter were recorded noninvasively in each vessel by tonometric and echotracking devices. The x-y composition of pressure and diameter waves provided the diameter-pressure hysteresis loop. The elastic diameter-pressure curve and wall viscosity index were deduced aft...<br/><br/>R Armentano, J L Megnien, A Simon, F Bellenfant, J Barra, J Levenson (1995) <i>Hypertension</i> <i></i> <i></i> 26: 1 48-54<br/>

http://publicationslist.org/alain.simon/refid72 2008-02-23T18:06:18Z

To evaluate arterial physiopathology, complete arterial wall mechanical characterization is necessary. This study presents a model for determining the elastic response of elastin (sigma E, where sigma is stress), collagen (sigma C), and smooth muscle (sigma SM) fibers and viscous (sigma eta) and inertial (sigma M) aortic wall behaviors. Our work assumes that the total stress developed by the wall ...<br/><br/>R L Armentano, J G Barra, J Levenson, A Simon, R H Pichel (1995) <i>Circ Res</i> <i></i> <i></i> 76: 3 468-478<br/>

http://publicationslist.org/alain.simon/refid67 2008-02-23T18:06:18Z

To evaluate changes in distal cutaneous arteries during hypertension, we used a noninvasive method to assess the compliance and vascular resistance of the hand radial arteries, mainly distributed to the skin, in 10 normotensive and 10 hypertensive (HT) men. Radial artery diameter and blood velocity were measured by means of pulsed Doppler concomitantly with measurements of finger arterial pressure...<br/><br/>E Heron, D Chemla, J L Megnien, J C Pourny, J Levenson, Y Lecarpentier, A Simon (1995) <i>J Appl Physiol</i> <i></i> <i></i> 79: 2 498-505<br/>

http://publicationslist.org/alain.simon/refid66 2008-02-23T18:06:18Z

Many techniques were proposed to assess erythrocyte aggregation in clinical and experimental investigations in view of in vitro determination. However no methodology until now is available to measure erythrocyte aggregation in flowing blood in vivo. High resolution ultrasonography provides an original way to quantify erythrocyte aggregation using the echogenicity of blood. We have developed and A-...<br/><br/>S M Razavian, J Levenson, P Peronneau, A Simon (1995) <i>J Cardiovasc Surg (Torino)</i> <i></i> <i></i> 36: 4 375-377<br/>

http://publicationslist.org/alain.simon/refid289 2007-07-14T07:38:51Z

Several non-pharmacological interventions such as weight reduction in obese subjects or diet alteration in subjects having hypercholesterolemia have been shown to be effective in therapeutic trials. Our aim was to test the value of two different ways of teaching patients about their diet. From March 1, 1993, to May 30, 1994, 300 consecutive patients seen in a one-day care hospital were randomised ...<br/><br/>A Massari, C Point, P Truffe, G Chatellier, A Simon, J Ménard (1995) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 88: 8 1101-1104<br/>

http://publicationslist.org/alain.simon/refid63 2008-02-23T18:06:18Z

Hypertension is a major risk factor for cardiovascular disease and atherosclerosis is the cause of most hypertensive complications. Therefore the detection of preclinical atherosclerosis may contribute to the better identification of hypertensive subjects at high risk of complications. Three main alterations are currently able to be diagnosed noninvasively: calcification, thickening, and stiffenin...<br/><br/>A Simon, J Levenson (1995) <i>Am J Hypertens</i> <i></i> <i></i> 8: 10 Pt 2 45S-48S<br/>

http://publicationslist.org/alain.simon/refid62 2008-02-23T18:06:18Z

OBJECTIVE: To study the relationship between high blood pressure and hyperlipidaemia and the cytosolic calcium concentration in unstimulated platelets, focusing on the effects of an alteration in membrane dynamics. MATERIALS AND METHODS: Basal cytosolic calcium concentrations were determined in the presence and the absence of a significant calcium influx in platelets of 47 untreated hypertensive p...<br/><br/>K H Le Quan Sang, J Levenson, A Simon, M A Devynck (1995) <i>J Hypertens</i> <i></i> <i></i> 13: 12 Pt 2 1575-1580<br/>

http://publicationslist.org/alain.simon/refid64 2008-02-23T18:06:18Z

BACKGROUND: Recent studies have suggested that knowledge of the extent of subclinical atherosclerosis may improve prognostic information in subjects at risk of cardiovascular disease. Therefore, we tested the value of extracoronary plaque detected with echography at multiple sites and that of total coronary calcification deposit evaluated with ultrafast computed tomography for predicting the risk ...<br/><br/>A Simon, P Giral, J Levenson (1995) <i>Circulation</i> <i></i> <i></i> 92: 6 1414-1421<br/>

http://publicationslist.org/alain.simon/refid65 2008-02-23T18:06:18Z

Fibrinogen may play an active role in the development and progression of atherosclerotic plaques. We assessed the association between fibrinogen levels and atherosclerotic plaques over three different arterial sites in an asymptomatic never-treated male population with increased cardiovascular risk. We included 652 men aged 40 to 60 years old with at least one of the following cardiovascular risk ...<br/><br/>J Levenson, P Giral, M Razavian, J Gariepy, A Simon (1995) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 15: 9 1263-1268<br/>

http://publicationslist.org/alain.simon/refid79 2008-02-23T18:06:18Z

A Simon, J Levenson (1994) <i>Atherosclerosis</i> <i></i> <i></i> 105: 2 245-249<br/>

http://publicationslist.org/alain.simon/refid81 2008-02-23T18:06:18Z

A description of the arterial wall elastic properties comprehends both collagen and elastin, clearly shown in a biphasic stress-strain relationship. From chronically instrumented conscious dogs, aortic pressure-diameter curves can be obtained in a single beat, which is impossible to perform in human beings. In control conditions, the collagen fibers are almost not distended and the resistance to s...<br/><br/>R L Armentano, E I Cabrera Fischer, J G Barra, J A Levenson, A C Simon, R H Pichel (1994) <i>Med Prog Technol</i> <i></i> <i></i> 20: 1-2 91-99<br/>

http://publicationslist.org/alain.simon/refid80 2008-02-23T18:06:18Z

Haemodynamic shear forces have been reported to exert direct and indirect effects on platelet reactivity. In vitro, they activate platelets leading to spontaneous or facilitated aggregation. In vivo, they stimulate the production of endothelium-derived anti-aggregatory agents. This study was designed to evaluate in hypertensive patients, before and after antihypertensive treatment, the possible ro...<br/><br/>M M Mazeaud, J Levenson, K H Le Quan Sang, A Simon, M A Devynck (1994) <i>Thromb Haemost</i> <i></i> <i></i> 71: 1 26-31<br/>

http://publicationslist.org/alain.simon/refid78 2008-02-23T18:06:18Z

Recent studies have suggested that rheological mechanisms may be involved in the pathogenesis of ischemic syndromes in hyperlipidemias. We investigated the association between erythrocyte aggregation and components of lipoproteins in the blood of 60 normotensive, hypercholesterolemic men aged 45 +/- 8 years. The rheological parameters assessed were aggregation index (AI) and disaggregation shear r...<br/><br/>S M Razavian, V Atger, P Giral, M Cambillau, M Del-Pino, A C Simon, N Moatti, J Levenson (1994) <i>Arterioscler Thromb</i> <i></i> <i></i> 14: 3 361-366<br/>

http://publicationslist.org/alain.simon/refid290 2007-07-14T07:38:51Z

Coronary calcifications (CC) are the witness of atheromatous disease because they lies in intima. This is a best stamp of coronary atheromatosis than all the well know risk factors. CC scores is perfectly estimated by EBT. The reproductibility expressed in logarithm data is 7.2% in inter-examination, 1.3% in inter-observers, 2% in intra-observers [4]. CC detection is more specific in young populat...<br/><br/>M C Plainfossé, J C Boudeville, V Sene, A Hernigou, P Challandre, A Simon (1994) <i>J Radiol</i> <i></i> <i></i> 75: 12 693-699<br/>

http://publicationslist.org/alain.simon/refid77 2008-02-23T18:06:18Z

The effects of isradipine (Lomir, CAS 75695-93-1) and metoprolol (CAS 37350-58-6) on geometry and arterial compliance of the arteria brachialis of 14 patients each with essential hypertension were compared acutely and after three months of therapy by means of pulsed Doppler sonography and the determination of pulse wave velocity. A calculation model was used that allowed to determine the drug-spec...<br/><br/>A Simon, I Merli, M Del Pino, M Bräutigam, D Welzel, K J Burger, J Levenson (1994) <i>Arzneimittelforschung</i> <i></i> <i></i> 44: 3 305-309<br/>

http://publicationslist.org/alain.simon/refid76 2008-02-23T18:06:18Z

OBJECTIVE: We set out to evaluate the relationship between aortic stiffness and serum lipids and lipoprotein fractions, including high-density-lipoprotein (HDL) cholesterol subfractions. METHODS: One hundred and five asymptomatic, normotensive, untreated, hypercholesterolaemic men underwent measurement of aortic pulse-wave velocity (PWV) by mecanography and assay of total cholesterol, triglyceride...<br/><br/>P Giral, V Atger, J Amar, M Cambillau, M Del Pino, J L Megnien, J Levenson, N Moatti, A Simon (1994) <i>J Cardiovasc Risk</i> <i></i> <i></i> 1: 1 53-58<br/>

http://publicationslist.org/alain.simon/refid89 2008-02-23T18:06:18Z

OBJECTIVE: The aim was to assess the influence of the renin-angiotensin system on the geometrical and elastic properties of the aorta in conscious dogs, using a model of renovascular hypertension, and to examine the effects of inhibition of the system by the angiotensin converting enzyme inhibitor spirapril. METHODS: The aortic elastic behaviour in response to renovascular hypertension was studied...<br/><br/>E I Fischer, J Levenson, J G Barra, R L Armentano, R H Pichel, A Simon (1993) <i>Cardiovasc Res</i> <i></i> <i></i> 27: 6 1039-1044<br/>

http://publicationslist.org/alain.simon/refid90 2008-02-23T18:06:18Z

Cross-sectional associations between aortic elasticity assessed by carotid to femoral pulse wave velocity (PWV) and cardiovascular risk factors were examined in 429 apparently healthy middle-aged women. PWV was strongly and positively related to blood pressure and hypertension. Weak but significant positive associations were also found between PWV and age, heart rate, some lipids and lipoproteins,...<br/><br/>A Taquet, C Bonithon-Kopp, A Simon, J Levenson, Y Scarabin, A Malmejac, P Ducimetiere, L Guize (1993) <i>Eur J Epidemiol</i> <i></i> <i></i> 9: 3 298-306<br/>

http://publicationslist.org/alain.simon/refid91 2008-02-23T18:06:18Z

To determine the effects of female hormones on peripheral vasculature we studied the brachial artery circulation. Nine young women (27-37 yrs) having inactive ovaries received transdermal estradiol (E2) (0.1-0.4 mg/d) and vaginal progesterone (P) (300 mg/d) to duplicate the menstrual cycle levels of E2 and P. Brachial artery diameter, blood velocity and flow were measured by bidimensional pulsed D...<br/><br/>J L Megnien, D de Ziegler, J Levenson, R Frydman, A Simon (1993) <i>Contracept Fertil Sex</i> <i></i> <i></i> 21: 4 313-316<br/>

http://publicationslist.org/alain.simon/refid87 2008-02-23T18:06:18Z

Little is known of the in vivo structural changes of large arteries in uncomplicated hypertension. Therefore, we measured the intima-media thickness and lumen diameter of common carotid and femoral arteries by a computerized ultrasonographic technique in 25 normotensive and 25 never treated hypertensive men of similar age (from 25 to 72 years). The intraobserver variability of carotid and femoral ...<br/><br/>J Gariepy, M Massonneau, J Levenson, D Heudes, A Simon (1993) <i>Hypertension</i> <i></i> <i></i> 22: 1 111-118<br/>

http://publicationslist.org/alain.simon/refid88 2008-02-23T18:06:18Z

The authors present a new strategy for cardiovascular disease prevention based on risk factor detection in occupational medicine and silent atherosclerosis detection in a specialized investigation centre. Employees from several firms in the Paris region were searched, in their working place, for cardiovascular risk factors, including blood cholesterol measurement. The subjects at risk thus selecte...<br/><br/>A Simon, P Segond, A M Giard, B Demure, R Gitel, J Levenson (1993) <i>Presse Med</i> <i></i> <i></i> 22: 22 1033-1038<br/>

http://publicationslist.org/alain.simon/refid86 2008-02-23T18:06:18Z

The effects of isradipine and metoprolol were studied on the brachial arteries of two groups of 14 patients with hypertension, 90 minutes after the first dose and after 3 months of treatment. Diameter (pulsed Doppler) and compliance (pulse-wave velocity) were measured and calculated in isobaric conditions by way of a model that allowed discrimination of the active intrinsic drug action. Isradipine...<br/><br/>I Merli, A Simon, M Del Pino, M Brautigam, D Welzel, J Levenson (1993) <i>Clin Pharmacol Ther</i> <i></i> <i></i> 54: 1 76-83<br/>

http://publicationslist.org/alain.simon/refid83 2008-02-23T18:06:18Z

K H Le Quan Sang, M Del Pino, J Levenson, A Simon, M A Devynck (1993) <i>J Hypertens Suppl</i> <i></i> <i></i> 11: 5 S260-S261<br/>

http://publicationslist.org/alain.simon/refid84 2008-02-23T18:06:18Z

1. To evaluate the response of red blood cells subjected to the shear flow in hypertension, the relationships between wall shear phenomena determined in vivo in the brachial artery of hypertensive patients and the modifications of the membrane dynamics measured in vitro in erythrocyte ghosts of 32 patients were investigated. 2. Two fluorescent probes, diphenylhexatriene (DPH) and its trimethylamin...<br/><br/>K H Le Sang Quan, J Levenson, M Del Pino, A Simon, M A Devynck (1993) <i>Br J Clin Pharmacol</i> <i></i> <i></i> 36: 5 437-443<br/>

http://publicationslist.org/alain.simon/refid82 2008-02-23T18:06:18Z

Early investigators found contradictory evidence that vascular smooth muscle activation reduces the elastic modulus of the arterial wall under isotonic conditions but increases it under isometric conditions, concomitant with increased pulse-wave velocity. We examined the individual contributions of aortic constituents to the elastic modulus of the aortic wall to determine if isobaric analysis prod...<br/><br/>J G Barra, R L Armentano, J Levenson, E I Fischer, R H Pichel, A Simon (1993) <i>Circ Res</i> <i></i> <i></i> 73: 6 1040-1050<br/>

http://publicationslist.org/alain.simon/refid85 2008-02-23T18:06:18Z

Subclinical atherosclerosis can be non-invasively detected via calcifications, thickening and stiffening of arteries. Coronary calcifications seen with ultrafast computed tomography are frequent in hypertension or hypercholesterolemia and synonymous of coronary atherosis but not of coronary stenosis. Wall thickening detectable by extracoronary ultrasonography may be characterized by an intimamedia...<br/><br/>A Simon, J Levenson (1993) <i>Clin Exp Hypertens</i> <i></i> <i></i> 15: 6 1069-1076<br/>

http://publicationslist.org/alain.simon/refid100 2008-02-23T18:06:18Z

Hypercholesterolemia and hypertension are two of the major risk factors associated with increased atherosclerotic vascular disease. An abnormal platelet function is one of the mechanisms proposed to participate in atherogenesis. This study was undertaken to find out whether hypercholesterolemia in hypertensive patients can change platelet lipid composition and reactivity. Twenty-nine untreated hyp...<br/><br/>M M Mazeaud, F Driss, K H Le Quan Sang, V Duranthon, J Levenson, A Simon, M A Devynck (1992) <i>Atherosclerosis</i> <i></i> <i></i> 94: 2-3 201-211<br/>

http://publicationslist.org/alain.simon/refid146 2008-02-23T18:06:18Z

BACKGROUND. The prevalence of coronary calcifications and extracoronary plaques was studied in patients with asymptomatic hypercholesterolemia. METHODS AND RESULTS. Ultrafast computed tomography for coronary calcification (presence or absence: calcium score) and echographic assessment of carotid, aortic, and femoral plaques were performed in 111 hypercholesterolemic men: 65% had coronary calcifica...<br/><br/>J L Megnien, V Sene, S Jeannin, A Hernigou, M C Plainfosse, I Merli, V Atger, N Moatti, J Levenson, A Simon (1992) <i>Circulation</i> <i></i> <i></i> 85: 5 1799-1807<br/>

http://publicationslist.org/alain.simon/refid149 2008-02-23T18:06:18Z

The effects of antihypertensive drugs on the large arteries consist of two parts: the passive effect due to the change in pressure and the active effect, the drug action per se. This study proposes a method of dissociating the passive effect from the active effect. The diameter of the arterial artery was determined by the pulsed Doppler method and the pulse wave velocity of the brachioradial arter...<br/><br/>N P Chau, A Simon, J Vilar, E Cabrera-Fischer, I Pithois-Merli, J Levenson (1992) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 19: 1 78-85<br/>

http://publicationslist.org/alain.simon/refid98 2008-02-23T18:06:18Z

Since calcium in coronary artery walls is considered as an indicator for atherosclerosis, we used ultrafast computed tomography to quantify it non invasively in 111 hypercholesterolemic men. They were selected at worksite by a cholesterol screening program, had total cholesterol (TC) above 5.2 (6.88 +/- 0.82, SD) mmol/l, were aged from 30 to 63 (46 +/- 5 years), had never been treated with lipid l...<br/><br/>J L Megnien, S Jeannin, V Sene, I Merli, V Atger, A Hernigou, M C Plainfosse, N Moatti, J Levenson, A Simon (1992) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 85: 8 1127-1129<br/>

http://publicationslist.org/alain.simon/refid148 2008-02-23T18:06:18Z

Arterial compliance in humans is generally measured by modeling analysis of pulse tracing or of pulse wave propagation in the arterial tree. It is decreased in hypertension in part because elevation of blood pressure stiffens the arteries by stretching the rigid collagen fibres of their walls. Using a modeling evaluation of the compliance-pressure relationship in large arteries, it is possible to ...<br/><br/>A C Simon, J Levenson, N P Chau, I Pithois-Merli (1992) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 19 Suppl 5: S11-S20<br/>

http://publicationslist.org/alain.simon/refid147 2008-02-23T18:06:18Z

Since Ca2+ ions seem to directly participate in the control of erythrocyte membrane structure and deformability and because cell Ca2+ metabolism has been repeatedly proposed to be modified in hypertension, the intracellular calcium ion concentration ([Ca2+]i) was investigated in red blood cells from hypertensive and normotensive subjects. [Ca2+]i was measured by using the fluorescent Ca2+ chelator...<br/><br/>M David-Dufilho, C Astarie, M G Pernollet, M Del Pino, J Levenson, A Simon, M A Devynck (1992) <i>Hypertension</i> <i></i> <i></i> 19: 2 167-174<br/>

http://publicationslist.org/alain.simon/refid99 2008-02-23T18:06:18Z

To evaluate the influence of hypercholesterolaemia on arterial and blood factors related to cardiovascular disease in hypertension, 20 normocholesterolaemic and 31 hypercholesterolaemic hypertensive patients underwent determinations of whole blood filterability (WBF), plasma fibrinogen concentration (PF) and aortic pulse wave velocity (PWV). Both of the groups had similar age, body mass index, cum...<br/><br/>J Levenson, M Del Pino, M Razavian, I Merli, V Filitti, A Simon (1992) <i>Atherosclerosis</i> <i></i> <i></i> 95: 2-3 171-179<br/>

http://publicationslist.org/alain.simon/refid92 2008-02-23T18:06:18Z

Differences exist between short- and long-term haemodynamic effects of diuretics. In the short term, plasma volume depletion is accompanied by increased peripheral vascular resistance and decreased cardiac output. In the long term cardiac output returns toward normal, peripheral resistance falls to below pretreatment values and blood volume remains lower than before therapy. This long-term decreas...<br/><br/>J Levenson, J Gariepy, J L Megnien, I P Merli, A Simon (1992) <i>Eur Heart J</i> <i></i> <i></i> 13 Suppl G: 48-52<br/>

http://publicationslist.org/alain.simon/refid97 2008-02-23T18:06:18Z

We have already reported that erythrocyte aggregation (EA) is increased in hypertensive subjects. To study the influence of other risk factors in EA, we have measured aggregation index IA and disaggregation shear rate threshold (gamma c) by a laser technique and the biochemical parameters in 16 normotensive normocholesterolemic subjects (NT/NCT) and 45 hypertensive subjects where 17 were normochol...<br/><br/>S M Razavian, M Del-Pino, C Duché, A Simon, J Levenson (1992) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 85: 8 1197-1199<br/>

http://publicationslist.org/alain.simon/refid94 2008-02-23T18:06:18Z

Systolic time intervals and brachial circulation, evaluated by pulsed Doppler in terms of arterial diameter, blood velocity and flow, and vascular resistance, were studied in 12 hyperthyroid patients and in 12 normal controls. In patients, arterial circulation was studied before and during mechanical exclusion of the hand, and hemodynamic measurements were repeated after beta-blocker treatment and...<br/><br/>P Valensi, A Simon, I Pithois-Merli, J Levenson (1992) <i>Angiology</i> <i></i> <i></i> 43: 12 996-1007<br/>

http://publicationslist.org/alain.simon/refid93 2008-02-23T18:06:18Z

OBJECTIVES. The effects of hypertension and diabetes on the physical properties of large arteries were compared in men. BACKGROUND. Although these two diseases are linked to vascular stiffening, no study has analyzed whether the arterial rigidity in diabetes is as substantial as in hypertension. METHODS. Noninvasive measurements of brachial artery mean pressure, diameter (pulsed Doppler study) and...<br/><br/>J L Megnien, A Simon, P Valensi, P Flaud, I Merli, J Levenson (1992) <i>J Am Coll Cardiol</i> <i></i> <i></i> 20: 7 1562-1568<br/>

http://publicationslist.org/alain.simon/refid96 2008-02-23T18:06:18Z

The aggregation and disaggregation behaviors of red blood cells were investigated in 17 normotensive and 21 hypertensive subjects with a laser reflectometry technique, and simultaneous measurements were taken of blood viscosity with a coaxial viscometer. Increased red blood cell aggregation (26%, p less than 0.001) and disaggregation shear rate (20%, p less than 0.01) and shear stress (18%, p less...<br/><br/>S M Razavian, M Del Pino, A Simon, J Levenson (1992) <i>Hypertension</i> <i></i> <i></i> 20: 2 247-252<br/>

http://publicationslist.org/alain.simon/refid95 2008-02-23T18:06:18Z

To investigate the role of lipoprotein (a) (Lp[a]) as an atherogenic condition related to hypercholesterolemia, we studied the serum concentration of Lp(a) as measured by immunonephelometry in relation to the presence of asymptomatic echographic plaques in the peripheral arteries of 103 untreated hypercholesterolemic, normotensive, middle-aged men. Plaque was found at carotid, aortic, and femoral ...<br/><br/>M Cambillau, A Simon, J Amar, P Giral, V Atger, P Segond, J Levenson, I Merli, J L Megnien, M C Plainfosse (1992) <i>Arterioscler Thromb</i> <i></i> <i></i> 12: 11 1346-1352<br/>

http://publicationslist.org/alain.simon/refid159 2008-02-23T18:06:18Z

Ultrasonic detection of atherosclerotic plaque of carotid abdominal aortic and femoral arteries and evaluation of risk factors were performed in 208 hypercholesterolemic men without cardiovascular disease. Twenty-six percent of them had no plaque. Plaque at the carotid, aortic, and femoral sites was found in 37%, 48%, and 53% of subjects, respectively. Plaque was associated (1) in carotid arteries...<br/><br/>P Giral, I Pithois-Merli, V Filitti, J Levenson, M C Plainfosse, C Mainardi, A C Simon (1991) <i>Arch Intern Med</i> <i></i> <i></i> 151: 5 950-956<br/>

http://publicationslist.org/alain.simon/refid158 2008-02-23T18:06:18Z

We studied the aortic elastic behavior in response to vitamin D3-induced accelerated calcinosis in conscious dogs chronically instrumented with a pressure microtransducer and a pair of ultrasonic diameter dimension gauges in the upper descending thoracic aorta. The two functional phases of the elastic segmental properties of the aorta in vivo were discriminated by computation on a beat-by-beat bas...<br/><br/>E I Cabrera Fischer, R L Armentano, J Levenson, J G Barra, M C Morales, G J Breitbart, R H Pichel, A Simon (1991) <i>Circ Res</i> <i></i> <i></i> 68: 6 1549-1559<br/>

http://publicationslist.org/alain.simon/refid160 2008-02-23T18:06:18Z

The effects of short-term administration of indomethacin and propranolol were studied in two groups of patients with borderline hypertension and both central and peripheral hyperkinesia. Indomethacin and propranolol both significantly increased total peripheral resistance (respectively +32 +/- 3%, +59 +/- 7%, p less than 0.001). The increase in blood pressure after administrating propranolol was n...<br/><br/>J L Megnien, J Levenson, A Simon (1991) <i>Therapie</i> <i></i> <i></i> 46: 3 223-225<br/>

http://publicationslist.org/alain.simon/refid163 2008-02-23T18:06:18Z

Both marked hypercholesterolemia and severe hypertension have been reported to be associated with an enhanced sensitivity of blood platelets to activating agents. To investigate a possible mutual synergistic effect of moderate hypercholesterolemia and mild hypertension on platelet reactivity, we studied in 29 patients the response to aggregating agents, ADP and collagen, and the intracellular cycl...<br/><br/>M M Mazeaud, K H Sang, C Astarie, J Levenson, A Simon, M A Devynck (1991) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 18 Suppl 10: S46-S51<br/>

http://publicationslist.org/alain.simon/refid157 2008-02-23T18:06:18Z

A Simon, I Merli, V Filitti, J Levenson (1991) <i>Ann Cardiol Angeiol (Paris)</i> <i></i> <i></i> 40: 6 329-334<br/>

http://publicationslist.org/alain.simon/refid162 2008-02-23T18:06:18Z

The diameter, blood velocity, and blood flow of the brachial artery were evaluated with a pulsed-Doppler apparatus before and after wrist occlusion in 16 normocholesterolemic and 27 hypercholesterolemic male subjects of similar age and body mass index. Before occlusion, no hemodynamic differences were observed between the two groups. Occlusion significantly reduced blood velocity and blood flow in...<br/><br/>V Filitti, P Giral, A Simon, I Merli, M Del Pino, J Levenson (1991) <i>Arterioscler Thromb</i> <i></i> <i></i> 11: 1 161-166<br/>

http://publicationslist.org/alain.simon/refid161 2008-02-23T18:06:18Z

Arterial compliance describes a change in the volume of arteries following a change in blood pressure. The physical basis of the compliance concept and experimental procedures in animals both indicate that the relation between arterial compliance and blood pressure pattern is often unclear. Compliance is pressure-dependent because of the biphasic elastin and collagen composition of arteries and, h...<br/><br/>A Simon, J Levenson (1991) <i>Am J Hypertens</i> <i></i> <i></i> 4: 1 Pt 1 97-105<br/>

http://publicationslist.org/alain.simon/refid154 2008-02-23T18:06:18Z

The purpose of this study was to estimate the effect of hypertension on the visco-elastic properties of the brachial artery in man. Seventy-five subjects including 23 with normal blood pressure (group N, PN = 95 +/- 7 mmHg, P designates the arterial mean pressure, P = DBP + (SBP-DBP)/3) and 52 with essential hypertension (group H, PH = 122 +/- 12 mmHg) participated to this study. We measured the d...<br/><br/>N P Chau, A Simon, P Flaud, J Vilar, J Levenson (1991) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 84: 8 1053-1055<br/>

http://publicationslist.org/alain.simon/refid152 2008-02-23T18:06:18Z

Hypertensive and diabetic mellitus diseases are known to increase stiffness of the arterial wall. However these alterations probably involve different mechanisms. To this end, we compared the effect of hypertension and diabetes on large artery caliber and elasticity at real pressure conditions and at the same level of pressure. Nine poorly controlled non insulino-dependent diabetic men without hyp...<br/><br/>J L Mégnien, A Simon, P Valensi, I Pithois-Merli, N Assad, J Attali, J Levenson (1991) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 84: 8 1101-1103<br/>

http://publicationslist.org/alain.simon/refid151 2008-02-23T18:06:18Z

Brachial artery diameter and compliance were measured in 23 normotensive control subjects and 49 hypertensive patients. The results were compared in isobaric conditions by a modeling analysis extrapolating from the measured data a short segment of the pressure-diameter and pressure-compliance curves in the artery. A logarithmic diameter-pressure function was used as well as measurements of brachia...<br/><br/>R Armentano, A Simon, J Levenson, N P Chau, J L Megnien, R Pichel (1991) <i>Hypertension</i> <i></i> <i></i> 18: 5 657-664<br/>

http://publicationslist.org/alain.simon/refid156 2008-02-23T18:06:18Z

The elastic behavior of total elastin (EE) and collagen (EC) and the recruitment of collagen fibers (FC) supporting wall stress at a given transmural pressure level were assessed in seven conscious dogs using descending thoracic aortic pressure (microtransducer) and diameter (sonomicrometer) measurements. Stress-strain relationships values calculated at control and during bolus administration of a...<br/><br/>R L Armentano, J Levenson, J G Barra, E I Fischer, G J Breitbart, R H Pichel, A Simon (1991) <i>Am J Physiol</i> <i></i> <i></i> 260: 6 Pt 2 H1870-H1877<br/>

http://publicationslist.org/alain.simon/refid153 2008-02-23T18:06:18Z

Aggregation index and critical disaggregation shear rate (which represent the minimum shear rate necessary to break up the aggregates) have been measured for 21 hypertensive and 17 normotensive subjects by a laser technique (erythro-aggregameter SEFAM). A simultaneous measurement of blood viscosity by a Couette viscometer with coaxial cylinders at different shear rate allowed the calculation of cr...<br/><br/>S M Razavian, M Del-Pino, A Chabanel, A Simon, J Levenson (1991) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 84: 8 1081-1083<br/>

http://publicationslist.org/alain.simon/refid155 2008-02-23T18:06:18Z

Hypertension may influence the atherosclerotic process of large arteries via pressure and shear forces. The pressure force dilates and stiffens arteries because of the non-linear elastic behaviour of arterial walls. This partly explains the increased diameter and decreased compliance of the brachial artery in hypertensive subjects compared with normotensive controls. However, pressure lowering by ...<br/><br/>A C Simon, I Pithois-Merli, J Levenson (1991) <i>J Hum Hypertens</i> <i></i> <i></i> 5 Suppl 1: 15-21<br/>

http://publicationslist.org/alain.simon/refid150 2008-02-23T18:06:18Z

K H Le Quan Sang, M Mazeaud, J Levenson, M Del Pino, I Pithois-Merli, A Simon, M A Devynck (1991) <i>J Hypertens Suppl</i> <i></i> <i></i> 9: 6 S410-S411<br/>

http://publicationslist.org/alain.simon/refid164 2008-02-23T18:06:18Z

1. Blood cells and vascular endothelial cells are subjected to a wide range of haemodynamically generated shear stress forces. In vitro, membrane stretching or shear stress have been observed to activate ion channels and cell metabolism and to facilitate erythrocyte and platelet aggregation. 2. The present study was designed to evaluate the participation of shear stresses in the control of apparen...<br/><br/>J Levenson, M A Devynck, I Pithois-Merli, K H Le Quan Sang, V Filitti, A Simon (1990) <i>Clin Sci (Lond)</i> <i></i> <i></i> 79: 6 613-618<br/>

http://publicationslist.org/alain.simon/refid168 2008-02-23T18:06:18Z

STUDY OBJECTIVE--The aim of the study was to evaluate in hypertensive subjects the longitudinal pressure drop and segmental resistance in a large artery in relation to shearing forces of the circulating blood column at the arterial wall. DESIGN--Arterial diameter, blood velocity, and flow were measured in the brachial artery using pulsed Doppler apparatus. Blood viscosity was measured at 96 s-1 wi...<br/><br/>A C Simon, P Flaud, J Levenson (1990) <i>Cardiovasc Res</i> <i></i> <i></i> 24: 8 623-626<br/>

http://publicationslist.org/alain.simon/refid174 2008-02-23T18:06:18Z

STUDY OBJECTIVE - The aim of the study was to examine oscillating arterial wall shear stress in hypertension. DESIGN - Pulsatile flow and oscillating wall shear stress were measured in brachial artery in hypertensive v normotensive subjects using pulsed Doppler apparatus. Methods were tested in four subjects using a micrometric procedure of Doppler probe displacement providing instantaneous real t...<br/><br/>A C Simon, J Levenson, P Flaud (1990) <i>Cardiovasc Res</i> <i></i> <i></i> 24: 2 129-136<br/>

http://publicationslist.org/alain.simon/refid175 2008-02-23T18:06:18Z

Brachial artery wall shear phenomena were studied in 20 untreated essential hypertensive patients and in 11 normotensive controls of similar age. A pulsed-Doppler velocimeter was used to measure brachial artery internal diameter and mean cross-sectional and systolic centreline blood velocities. A coaxial-cylinder viscometer was used to measure blood viscosity at a shear rate of 96 s-1. A Poiseuill...<br/><br/>A C Simon, J Levenson (1990) <i>J Hypertens</i> <i></i> <i></i> 8: 2 109-114<br/>

http://publicationslist.org/alain.simon/refid176 2008-02-23T18:06:18Z

A new geometric procedure determination of velocity profiles inside large human arteries, such as the brachial and femoral, has been developed. The procedure requires the use of two crystal element Doppler probes and a highly precise micromanipulator with three degrees of freedom. Precise positioning is needed to obtain the required high degree of parallelism between the vessel axis and the plane ...<br/><br/>P Flaud, A Bensalah, J L Counord, J Levenson, A Simon (1990) <i>Ann Biomed Eng</i> <i></i> <i></i> 18: 5 519-531<br/>

http://publicationslist.org/alain.simon/refid165 2008-02-23T18:06:18Z

The relations between carotid arteries and/or abdominal aortic plaque and cardiovascular risk factors were investigated by ultrasonography in 161 untreated hypercholesterolemic normotensive men. Of them, 58 had no plaque (NP group), 34 had carotid but not aortic plaque (CP group), 34 had aortic but not carotid plaque (AP group) and 35 had both carotid and aortic plaques (CAP group). Groups signifi...<br/><br/>P Giral, V Filitti, J Levenson, I Pithois-Merli, M C Plainfosse, C Mainardi, A Gold, A Simon (1990) <i>Atherosclerosis</i> <i></i> <i></i> 85: 2-3 151-159<br/>

http://publicationslist.org/alain.simon/refid172 2008-02-23T18:06:18Z

Brachial and carotid artery diameters, blood velocities and blood flows were determined by a pulsed-Doppler flowmeter in 22 normotensive and 74 mild to moderate essential hypertensive subjects, aged 46 +/- 8 years. The product age x MAP/1000 (where MAP is mean arterial blood pressure), called 'arterial age' (expressed in years x mmHg/1000), was used to assess the progress of age and blood pressure...<br/><br/>P C Nguyen, J Levenson, A Simon (1990) <i>J Hypertens</i> <i></i> <i></i> 8: 5 449-455<br/>

http://publicationslist.org/alain.simon/refid173 2008-02-23T18:06:18Z

Brachial artery flow patterns were studied in 10 hyperthyroid and 10 normal subjects. Mean blood velocity and flow were evaluated by pulsed Doppler, and peak systolic acceleration was calculated by computer-assisted digitization of the instantaneous velocity curve. Compared to control subjects, hyperthyroid patients had higher velocity and flow (p less than 0.01, p less than 0.02) and higher peak ...<br/><br/>D Chemla, J Levenson, P Valensi, Y LeCarpentier, J C Pourny, I Pithois-Merli, A Simon (1990) <i>Am J Cardiol</i> <i></i> <i></i> 65: 7 494-500<br/>

http://publicationslist.org/alain.simon/refid171 2008-02-23T18:06:18Z

To determine the effects of parasympathetic blockade and beta-blockade on the elastic response of aortic stiffness to vasopressive interventions, we studied 5 unanesthetised adult mongrel dogs by means of a pressure microtransducer and two ultrasonic crystals positioned at opposing sites in the proximal descending thoracic aorta which were used for diameter measurements. Systolic and diastolic cha...<br/><br/>R Armentano, E Cabrera, J Levenson, J Barra, G Breitbart, R Pichel, A Simon (1990) <i>Am J Hypertens</i> <i></i> <i></i> 3: 6 Pt 1 476-481<br/>

http://publicationslist.org/alain.simon/refid166 2008-02-23T18:06:18Z

Since resistance to flow is theoretically determined by arteriolar geometry and blood viscosity, we studied these two factors in 44 normal and 106 hypertensive subjects. Brachial bed vascular resistance was calculated as the ratio between mean pressure and brachial artery flow. Systemic blood viscosity in vitro was determined at 96 per s, while microvessel blood viscosity in vivo was estimated fro...<br/><br/>J Levenson, P Flaud, M Del Pino, A Simon (1990) <i>J Hypertens</i> <i></i> <i></i> 8: 11 1049-1055<br/>

http://publicationslist.org/alain.simon/refid169 2008-02-23T18:06:18Z

A new non-invasive methodology of measurement of pulsatile wall shear in superficial large arteries in man is presented from simple determinations of internal diameter of large artery and centerline instantaneous blood velocity (pulsed Doppler apparatus) and asymptotic blood viscosity (coaxial cylinder viscometer). Pulsatile distribution of velocity across the arterial lumen has been represented b...<br/><br/>J M Colin, M Del-Pino, J P Aouate, P Flaud, J Levenson, A Simon (1990) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 83: 8 1201-1203<br/>

http://publicationslist.org/alain.simon/refid167 2008-02-23T18:06:18Z

Hypertension may induce early alterations in large arteries by 2 mechanical stresses: one related to intravascular pressure, the other to blood flow dynamics. Distending pressure force acts in a circumferential direction, inducing decreased arterial distensibility. Arterial distensibility can be evaluated in humans by measurement of arterial compliance and pulse-wave velocity. It is well establish...<br/><br/>J Levenson, I Pithois-Merli, A Simon (1990) <i>Am J Cardiol</i> <i></i> <i></i> 66: 9 39C-42C<br/>

http://publicationslist.org/alain.simon/refid170 2008-02-23T18:06:18Z

Systolic wall shear conditions were studied in the brachial artery of 4 groups of subjects including 11 non-smokers normotensives (NSNT), 25 non smokers hypertensives (NSHT), 21 smokers normotensives (SNT) and 10 smokers hypertensives (SHT). Brachial artery diameter (D) and systolic centerline blood velocity (VCLS) were measured with a pulsed Doppler device and blood viscosity at 96 sec-1 was meas...<br/><br/>A Simon, M Del Pino, P Flaud, V Filitti, J Levenson (1990) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 83: 8 1081-1084<br/>

http://publicationslist.org/alain.simon/refid183 2008-02-23T18:06:18Z

Pulsatile wall shear conditions close to the brachial artery were evaluated in 11 normotensive and in 19 hypertensive patients of similar age by determining arterial diameter and centerline blood velocity with a pulsed Doppler and blood viscosity at 96 sec-1 with a coaxial cylinder viscometer. A Womersley model of intraluminal distribution of blood velocities enabled to determine from unsteadiness...<br/><br/>P Flaud, A Simon, I Pithois-Merli, J Levenson (1989) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 82: 7 1073-1075<br/>

http://publicationslist.org/alain.simon/refid185 2008-02-23T18:06:18Z

Alterations in the metabolism of intracellular messengers, such as calcium and cyclic adenosine 5'-phosphate (cAMP), have been reported in essential hypertension. Since intracellular pH (pHi) participates in the control of fundamental cell functions, we looked for changes in platelet cytosolic H+ concentration [( H+]i) in hypertension and investigated whether or not its impaired metabolism is link...<br/><br/>C Astarie, J Levenson, A Simon, P Meyer, M A Devynck (1989) <i>J Hypertens</i> <i></i> <i></i> 7: 6 485-491<br/>

http://publicationslist.org/alain.simon/refid184 2008-02-23T18:06:18Z

The effects of a single oral dose of 20 mg of nicorandil were evaluated in 12 untreated patients with mild to moderate essential hypertension. Serial measurements of arterial pressures were obtained by means of an automatic device (Dynamap) up to 120 minutes after drug administration. Forearm hemodynamics were determined with a pulsed Doppler velocimeter, or strain gauge mecanography and plethysmo...<br/><br/>J Levenson, J Bouthier, N P Chau, E Roland, A C Simon (1989) <i>Am J Cardiol</i> <i></i> <i></i> 63: 21 40J-43J<br/>

http://publicationslist.org/alain.simon/refid182 2008-02-23T18:06:18Z

Essential hypertension is associated with various cell abnormalities, including alterations in the metabolism of intracellular messengers, such as cytosolic free Ca2+ and cyclic AMP or IP3. Intracellular pH is implicated in the regulation of number vital functions, including cell metabolism, division and response to various stimuli. We have measured cytosolic H+ concentration ([H+]i) in human plat...<br/><br/>C Astarie, J Levenson, A Simon, P Meyer, M A Devynck (1989) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 82: 7 1173-1176<br/>

http://publicationslist.org/alain.simon/refid186 2008-02-23T18:06:18Z

The effects of ketanserin (40 mg p.o.) on blood pressure and brachial haemodynamics (brachial artery diameter, brachial blood velocity and blood flow) have been compared in a double-blind study with those of ritanserin (10 mg p.o.) and placebo. Haemodynamic parameters were measured before and 1 h after treatment. Patients with mild to moderate essential hypertension participated in this study, 6 e...<br/><br/>N P Chau, I Pithois-Merli, J Levenson, A C Simon (1989) <i>Eur J Clin Pharmacol</i> <i></i> <i></i> 37: 3 215-220<br/>

http://publicationslist.org/alain.simon/refid181 2008-02-23T18:06:18Z

Arteriolar geometry and blood viscosity, the two main factors determining vascular resistance were studied in 44 normotensive subjects and 106 hypertensive patients at the brachial circulation level. Vascular resistance was calculated as the ratio between mean blood pressure and mean arterial flow determined by pulsed Doppler. Blood viscosity at 240 sec-1 was measured with a coaxial cylinder visco...<br/><br/>J Levenson, I Merli, P Flaud, A Simon (1989) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 82: 7 1177-1179<br/>

http://publicationslist.org/alain.simon/refid178 2008-02-23T18:06:18Z

Aortic compliance is a major determinant of systolic blood pressure and of impedance to left ventricular ejection. However, little is known about its regulating factors. To assess the effects of preload and adrenergic activity on aortic compliance, we studied 10 normal subjects and nine untreated hypertensive patients at rest and during lower body negative pressure. Aortic compliance was measured ...<br/><br/>M A Madkour, J Levenson, E L Bravo, A Simon, F M Fouad-Tarazi (1989) <i>Am Heart J</i> <i></i> <i></i> 118: 6 1243-1247<br/>

http://publicationslist.org/alain.simon/refid177 2008-02-23T18:06:18Z

The long-term effects of selective (atenolol) and nonselective (carteolol) beta-blockers on brachial artery diameter velocity and flow and on vascular resistance (pulsed Doppler) were compared in two groups of 10 hypertensive patients at respective daily doses of 100 and 20 mg. The drugs decreased mean blood pressure (p less than 0.01) with similar magnitude, although systolic blood pressure was d...<br/><br/>I P Merli, J Levenson, V Filitti, A Simon (1989) <i>Clin Pharmacol Ther</i> <i></i> <i></i> 46: 6 686-692<br/>

http://publicationslist.org/alain.simon/refid179 2008-02-23T18:06:18Z

Effects of experimental calcinosis induced by daily overdose of 500.000 IU Vit D3 during 10 days were studied in 6 mongrel conscious dogs chronically instrumented with intra-aortic Konigsberg microtransducer and two ultrasonic piezo-electric crystals diametrically opposed in the adventitia of the descending thoracic aorta. Simultaneous recording of instantaneous aortic pressure and diameter waves ...<br/><br/>R Armentano, J Levenson, E Cabrera, R Pichel, A Simon (1989) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 82: 7 1159-1162<br/>

http://publicationslist.org/alain.simon/refid180 2008-02-23T18:06:18Z

Segmental pressure drop and longitudinal resistance of brachial artery were evaluated in 11 normotensive (NT) and 19 hypertensive (HT) subjects of similar age by measuring arterial diameter (D), blood velocity (V) and flow (Q) with pulsed Doppler and blood viscosity (mu) at 96 sec-1 with a coaxial cylinder viscometer. Mean pressure drop (delta P) per unit of length of artery was calculated accordi...<br/><br/>A Simon, P Flaud, I Pithois-Merli, J Levenson (1989) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 82: 7 1181-1183<br/>

http://publicationslist.org/alain.simon/refid192 2008-02-23T18:06:18Z

The simultaneous acute effects of converting enzyme inhibition by intravenous enalaprilat on the circulating renin-angiotensin system and on the brachial artery were studied in 12 hypertensive patients by a double-blind comparison with saline effects in 14 hypertensive patients. The brachial artery was investigated in terms of arterial section (measured by pulsed Doppler technique) and wall rigidi...<br/><br/>J Levenson, N P Chau, E Billaud, A Simon (1988) <i>Am J Cardiol</i> <i></i> <i></i> 61: 13 1056-1060<br/>

http://publicationslist.org/alain.simon/refid193 2008-02-23T18:06:18Z

The effects of sex, hypertension, morphologic status, and heart rate were assessed on the large arteries of 46 normotensive subjects (23 men and 23 women) and 50 hypertensive patients (25 men and 25 women) by means of pulsed Doppler determination of diameter and blood velocity of the brachial artery. Compared to men, women had lower height, weight, and forearm volume (P less than 0.001), higher he...<br/><br/>A C Simon, J Levenson, F Cambien, J Bouthier (1988) <i>Am J Hypertens</i> <i></i> <i></i> 1: 2 119-123<br/>

http://publicationslist.org/alain.simon/refid195 2008-02-23T18:06:18Z

The vascular impact of different antihypertensive drugs was assessed in patients with mild to moderate essential hypertension by the use of the forearm circulation as a simple model to characterise the geometrical and distensible properties of the arterial system. The acute and chronic responses of the forearm arteries, expressed in terms of geometry (vasodilatation or vasoconstriction) and disten...<br/><br/>J Levenson, A Simon (1988) <i>Drugs</i> <i></i> <i></i> 35 Suppl 5: 34-39<br/>

http://publicationslist.org/alain.simon/refid194 2008-02-23T18:06:18Z

The elasticity of the thoracic aorta was studied in nine dogs instrumented with a pressure microtransducer and two ultrasonic crystals diametrically fixed in the adventitia. Systolic and diastolic changes in pressure and diameter were used to calculate Peterson and incremental elastic moduli. Acute hypertension was induced by infusions of angiotensin performed 1) during the control period, 2) afte...<br/><br/>E Cabrera, J Levenson, R Armentano, J Barra, R Pichel, A Simon (1988) <i>Hypertension</i> <i></i> <i></i> 11: 2 Pt 2 I103-I107<br/>

http://publicationslist.org/alain.simon/refid189 2008-02-23T18:06:18Z

Right brachial artery and common carotid artery haemodynamic parameters were studied using pulsed Doppler velocimetry enabling non invasive measurements of their internal diameters and blood velocities in 74 untreated essential hypertensive patients subdivided in two groups of younger than (33 patients) and older than 45 years (41 patients). There were no significant differences in the haemodynami...<br/><br/>J Bouthier, N P Chau, R Gitel, J Levenson, A C Simon (1988) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 81 Spec No: 59-63<br/>

http://publicationslist.org/alain.simon/refid187 2008-02-23T18:06:18Z

Wall shear phenomena were studied in the brachial artery in non-smoking and smoking normotensive and hypertensive subjects of similar age. Pulsed Doppler investigation revealed brachial artery diameter, and mean and systolic blood velocities (at the centerline of the vessel). A Poiseuillean blood velocity distribution was used to determine the wall shear rate and stress from velocity, diameter and...<br/><br/>J Levenson, A Simon (1988) <i>J Hypertens Suppl</i> <i></i> <i></i> 6: 4 S176-S178<br/>

http://publicationslist.org/alain.simon/refid188 2008-02-23T18:06:18Z

The aortic elastic behavior has been studied in conscious dogs chronically instrumented with a pressure microtransducer and two ultrasonic crystals. Pressure and diameter measurements were analyzed in terms of their mean values and systolic-diastolic variations, enabling calculation of Peterson elastic modulus, and were displayed in the x-y form to obtain pressure diameter hysteresis loops. After ...<br/><br/>E Cabrera, J Levenson, R Armentano, J Barra, R Pichel, A C Simon (1988) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 12: 6 643-649<br/>

http://publicationslist.org/alain.simon/refid196 2008-02-23T18:06:18Z

To assess the vascular involvement of renin-angiotensin system inhibition in human hypertension, acute effects of intravenous enalaprilat on brachial artery diameter, blood flow, and blood velocity were investigated in hypertensive patients by pulsed Doppler technique and compared with effects of saline vehicle. Compared with saline vehicle, enalaprilat reduced blood pressure (P less than 0.001) a...<br/><br/>A C Simon, N P Chau, J Levenson (1988) <i>Clin Pharmacol Ther</i> <i></i> <i></i> 43: 1 49-54<br/>

http://publicationslist.org/alain.simon/refid190 2008-02-23T18:06:18Z

Brachial artery wall shear rate and stress were studied in 20 untreated hypertensive patients and 11 normotensive controls of similar age. A pulsed Doppler velocimeter enabled to determine the internal diameter, the mean cross-sectional blood velocity and the systolic centerline blood velocity of the brachial artery. A coaxial cylinder viscosimeter provided blood viscosity at a shear rate of 96 s-...<br/><br/>A Simon, J Levenson (1988) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 81 Spec No: 51-54<br/>

http://publicationslist.org/alain.simon/refid191 2008-02-23T18:06:18Z

The elastic response of the thoracic aorta to increasing steps of angiotensin was studied in chronic instrumented conscious dogs with and without parasympathetic blockade by atropine. A pressure microtransducer and two ultrasonic crystals diametrically opposed and fixed in the adventitia enabled to determine the mean and systolic-diastolic changes of pressure (P) and diameter (D). By computing the...<br/><br/>E Cabrera, J Levenson, R Armentano, I Pithois-Merli, J Barra, R Pichel, A Simon (1988) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 81 Spec No: 129-132<br/>

http://publicationslist.org/alain.simon/refid207 2008-02-23T18:06:18Z

A cross-sectional study of 85 patients with poorly controlled treated hypertension was performed to detect, by means of aortic pulse wave velocity measurement and ultrasonic examinations, subclinical alterations of arteries. Pulse wave velocity was related to the product of age and diastolic blood pressure (BP) according to a nomogram obtained from normotensive subjects, and was found inside the n...<br/><br/>B Maarek, A C Simon, J Levenson, I Pithois-Merli, J Bouthier (1987) <i>Am J Cardiol</i> <i></i> <i></i> 59: 5 414-417<br/>

http://publicationslist.org/alain.simon/refid206 2008-02-23T18:06:18Z

Quantitative evaluation of brachial artery diameter, blood velocity and flow (pulsed Doppler velocimetry) and of forearm arterial compliance (FAC)--mathematical analysis of the simultaneous diastolic pressure and flow according to a first-order arterial model--was carried out in 10 normotensive controls, and in 23 borderline hypertensive patients, of the same age. Using a value of 2 standard devia...<br/><br/>A Simon, J Levenson, J Bouthier, B Maarek (1987) <i>J Hypertens</i> <i></i> <i></i> 5: 2 179-184<br/>

http://publicationslist.org/alain.simon/refid205 2008-02-23T18:06:18Z

The brachial artery diameter and blood flow rate were measured by pulsed Doppler velocimetry in 9 healthy subjects and 24 patients of the same age group with borderline hypertension. To evaluate the results, the patients were divided into two groups according to their cardiac output: high cardiac output group (i.e. patients whose cardiac output was superior to the mean +/- 2 S.D. value in the cont...<br/><br/>J D Bouthier, A C Simon, J Levenson (1987) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 80: 6 771-775<br/>

http://publicationslist.org/alain.simon/refid208 2008-02-23T18:06:18Z

We have studied the efficacy of clonidine hydrochloride administered transdermally once a week for 9 to 15 weeks in 12 patients with mild to moderate hypertension. Clonidine reduced both supine and standing blood pressures on average, but only 8 subjects were responders, i.e. had a decrease in supine diastolic blood pressure to below 90 mm Hg or more than 10% from baseline. Supine heart rate was u...<br/><br/>A Achimastos, X Girerd, A C Simon, I Pithois-Merli, J Levenson (1987) <i>Eur J Clin Pharmacol</i> <i></i> <i></i> 33: 2 111-114<br/>

http://publicationslist.org/alain.simon/refid209 2008-02-23T18:06:18Z

The relationship between cardiac hypertrophy, ventricular function, and aortic volume distensibility was studied in men with sustained essential hypertension by echocardiography and determination of pulse-wave velocity. The more reduced the aortic distensibility, the higher was the blood pressure response to exercise and the greater were the degree of cardiac hypertrophy and the modifications in s...<br/><br/>M E Safar, J J Toto-Moukouo, J A Bouthier, R E Asmar, J A Levenson, A C Simon, G M London (1987) <i>Circulation</i> <i></i> <i></i> 75: 1 Pt 2 I156-I161<br/>

http://publicationslist.org/alain.simon/refid210 2008-02-23T18:06:18Z

1. Hypertension is associated with a distension of the large arteries and consequently a marked reduction in arterial compliance, which does not result merely from the mechanical effects of elevated arterial pressure but also from early functional and/or structural changes in the arterial walls. This suggests that one of the aims of antihypertensive therapy should be to reverse these arterial abno...<br/><br/>A C Simon, J Levenson, I Pithois-Merli (1987) <i>Br J Clin Pharmacol</i> <i></i> <i></i> 24 Suppl 1: 45S-49S<br/>

http://publicationslist.org/alain.simon/refid204 2008-02-23T18:06:18Z

The viscoelastic behaviour of the aorta has been studied in 7 adult non-anesthesized mongrel dogs, chronically instrumented with a microtransducer pressure (Konigsberg P7) implanted inside the aortic lumen, and 2 ultrasonic crystals diametrically opposed and fixed in the adventitia of the thoracic aorta. Pressure and diameter were analysed in terms of mean values and of systolic diastolic variatio...<br/><br/>E Cabrera, J Levenson, R Armentano, J C Barra, R Pichel, A Simon (1987) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 80: 6 789-793<br/>

http://publicationslist.org/alain.simon/refid203 2008-02-23T18:06:18Z

The purpose of the study was to assess whether cigarettes smoking could induce blood hyperviscosity and arterial rigidity in 30 normotensive and 70 hypertensive men aged from 24 to 65 years. Of those, 20 normotensive and 20 hypertensive were cigarettes smokers, while the remaining subjects were non smokers. Age and weight were similar in the 4 groups of subjects. A couette viscometer with coaxial ...<br/><br/>J Levenson, A C Simon, F Cambien, C Beretti (1987) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 80: 6 794-798<br/>

http://publicationslist.org/alain.simon/refid198 2008-02-23T18:06:18Z

The effects of sex, hypertension, morphological status, and heart rate were assessed on the large arteries of 46 normotensive subjects (23 men and 23 women) and 50 hypertensive patients (25 men and 25 women) by means of pulsed Doppler determination of diameter and blood velocity of the brachial artery. Compared with men, women had lower height, weight, and forearm volume (p less than 0.001), highe...<br/><br/>A C Simon, J Levenson, F Cambien, J Bouthier (1987) <i>J Clin Hypertens</i> <i></i> <i></i> 3: 4 617-623<br/>

http://publicationslist.org/alain.simon/refid199 2008-02-23T18:06:18Z

The effects of cigarette smoking and hypertension on hemorheological variables (blood viscosity over a wide range of shear rates, plasma viscosity, microhematocrit, and plasma protein concentration) and on arterial stiffness (pulse wave velocity) were investigated in 33 normotensive men and 81 mild to moderately hypertensive men. Of these, 22 normotensive and 24 hypertensive subjects were cigarett...<br/><br/>J Levenson, A C Simon, F A Cambien, C Beretti (1987) <i>Arteriosclerosis</i> <i></i> <i></i> 7: 6 572-577<br/>

http://publicationslist.org/alain.simon/refid200 2008-02-23T18:06:18Z

Studies in humans have shown that chronic elevation of blood pressure induces early alterations in the large arteries, consisting mainly of increased diameter, increased pulse wave velocity, and decreased arterial compliance. Acute reduction of blood pressure, per se, does not necessarily correct these alterations homogeneously. For instance, cadralazine reduced brachial artery diameter and urapid...<br/><br/>J Levenson, K H Le Quan Sang, M A Devynck, R Gitel, A Simon (1987) <i>Am Heart J</i> <i></i> <i></i> 114: 4 Pt 2 992-997<br/>

http://publicationslist.org/alain.simon/refid201 2008-02-23T18:06:18Z

Diameter, blood velocity, and flow of the brachial artery and vascular resistance of the brachial circulation were evaluated with a pulsed Doppler velocimeter before and after wrist occlusion in 8 younger and 8 older normotensive subjects and in 11 younger and 11 older hypertensive patients. Before occlusion, no differences existed between younger and older normotensives. However, in hypertensives...<br/><br/>J Levenson, A Simon, I Pithois-Merli (1987) <i>Am J Physiol</i> <i></i> <i></i> 253: 2 Pt 2 H217-H224<br/>

http://publicationslist.org/alain.simon/refid197 2008-02-23T18:06:18Z

It has been proposed that plasma cholesterol, a major risk factor for atherosclerosis, may modify cellular Ca2+. In particular, higher membrane cholesterol contents induce higher Ca2+ influx and decrease the activity of the Ca2+ pumps. Cellular Ca2+ may also control the number of accessible low density lipoprotein receptors. We investigated the question of whether plasma cholesterol influences cel...<br/><br/>K H Le Quan-Sang, J Levenson, A Simon, P Meyer, M A Devynck (1987) <i>J Hypertens Suppl</i> <i></i> <i></i> 5: 5 S251-S254<br/>

http://publicationslist.org/alain.simon/refid202 2008-02-23T18:06:18Z

Hypertension in older atherosclerotic patients is characterised by a disproportionate elevation of systolic and pulse pressure contrasting with a subnormal diastolic level. Increased systolic pressure is strongly related to the excess of cerebrovascular complications and congestive heart failure observed in these patients. The physiopathological pattern is marked by a strong reduction in complianc...<br/><br/>A Simon, J Levenson (1987) <i>Int J Cardiol</i> <i></i> <i></i> 16: 1 1-18<br/>

http://publicationslist.org/alain.simon/refid218 2008-02-23T18:06:19Z

The effect of beta-blockade was studied in 3 different kinds of human hypertension: borderline, sustained and isolated systolic hypertension. Young patients with borderline hypertension had a similar decrease in cardiac output with both nonselective and selective beta-blockade. Only nonselective beta-blockade decreased brachial artery blood flow and increased forearm vascular resistance. In patien...<br/><br/>J A Levenson, A C Simon, J E Zabludowski, M E Safar (1986) <i>Am J Nephrol</i> <i></i> <i></i> 6 Suppl 2: 88-93<br/>

http://publicationslist.org/alain.simon/refid217 2008-02-23T18:06:19Z

Forearm venous tone and brachial artery hemodynamics, including determinations of the arterial diameter and compliance by the use of pulsed Doppler systems, were measured in 16 patients with sustained essential hypertension before and after acute oral cadralazine dosing. Systolic and diastolic blood pressures significantly decreased, whereas heart rate increased. Brachial artery diameter and vascu...<br/><br/>J A Bouthier, M E Safar, N D Curien, G M London, J A Levenson, A C Simon (1986) <i>Clin Pharmacol Ther</i> <i></i> <i></i> 39: 1 82-88<br/>

http://publicationslist.org/alain.simon/refid219 2008-02-23T18:06:19Z

Quantitative evaluation of brachial artery diameter and blood flow (pulsed Doppler velocimetry) was carried out in nine normal subjects and 24 borderline hypertensive patients of the same age. The analysis of patients according to their value of cardiac index compared with the normal mean value plus 2 SD (standard deviation) enabled us to subdivide the patients into those with normal cardiac outpu...<br/><br/>A C Simon, J Levenson, B Maarek, J Bouthier, M E Safar (1986) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 8 Suppl 5: S36-S38<br/>

http://publicationslist.org/alain.simon/refid220 2008-02-23T18:06:19Z

Brachial artery diameter (pulsed Doppler method), forearm vascular resistance, and venous tone (plethysmographic method) were studied in 18 patients with sustained essential hypertension. Hemodynamic parameters were reevaluated after 3 months of treatment by propranolol (9 patients) or pindolol (9 patients). For the same decrease in pressure, propranolol decreased heart rate significantly while pi...<br/><br/>B L Maarek, J A Bouthier, A C Simon, J A Levenson, M E Safar (1986) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 8 Suppl 4: S61-S66<br/>

http://publicationslist.org/alain.simon/refid211 2008-02-23T18:06:18Z

The buffering function of arteries consists of damping down cardiac pulsatility. This function can be evaluated by measuring arterial compliance using pulsed Doppler and pulse wave velocity measurements and analysis of pressure and flow waves in arteries. In human hypertension, the reduction of arterial compliance is well-documented; it is not only due to increased stretching of the arteries conse...<br/><br/>A Simon, J Levenson (1986) <i>Presse Med</i> <i></i> <i></i> 15: 45 2243-2246<br/>

http://publicationslist.org/alain.simon/refid215 2008-02-23T18:06:18Z

The effects of pindolol were studied on the large arteries, arterioles, and veins of the forearm in 13 patients with essential hypertension after 12 weeks of dosing. The methods used were pulsed Doppler velocimetry of the brachial artery and strain gauge mercury-in-silicone rubber plethysmography of the forearm. Compared with placebo baseline values, chronic pindolol significantly decreased systol...<br/><br/>B Maarek, A C Simon, J Levenson, I Merli, J Bouthier (1986) <i>Clin Pharmacol Ther</i> <i></i> <i></i> 39: 4 403-408<br/>

http://publicationslist.org/alain.simon/refid216 2008-02-23T18:06:19Z

The haemodynamic pattern of the common carotid artery was studied in men with sustained essential hypertension using pulsed Doppler methods before and after administration of vasodilating drugs. Captopril produced both a fall in vascular resistance and an increase in arterial diameter of the common carotid artery. Isosorbide dinitrate increased markedly the arterial diameter but did not change vas...<br/><br/>J D Bouthier, M E Safar, A Benetos, A C Simon, J A Levenson, C M Hugues (1986) <i>Br J Clin Pharmacol</i> <i></i> <i></i> 21: 2 137-142<br/>

http://publicationslist.org/alain.simon/refid212 2008-02-23T18:06:18Z

The effect of a sustained-release oral isosorbide dinitrate (ISDN) preparation on cerebral and forearm circulation was determined in 16 patients with mild to moderate essential hypertension. Measurements were made by pulsed Doppler velocimetry in the common carotid and the brachial arteries. Pulse wave velocity of the forearm was simultaneously recorded by means of strain gauge arterial mechanogra...<br/><br/>J Levenson, A Simon, J Bouthier, A Benetos, M E Safar (1986) <i>Eur Heart J</i> <i></i> <i></i> 7: 10 898-903<br/>

http://publicationslist.org/alain.simon/refid213 2008-02-23T18:06:18Z

Pharmacokinetics of isosorbide dinitrate (ISDN) and brachial arterial hemodynamics have been studied in 15 patients with sustained essential hypertension. The hemodynamic study was performed by using a pulsed Doppler device enabling evaluation of the diameter of the brachial artery with an error of less than 10%. After intravenous administration until plateau concentrations were reached, the ISDN ...<br/><br/>A M Frydman, M E Safar, A C Simon, J A Levenson, J Gaillot, E Roland (1986) <i>Angiology</i> <i></i> <i></i> 37: 8 581-591<br/>

http://publicationslist.org/alain.simon/refid214 2008-02-23T18:06:18Z

The effects of medroxalol, a new beta-blocking drug, were simultaneously studied on the brachial artery, the arterioles and the veins of the forearm in 15 patients with mild to moderate essential hypertension after administration of a single oral dose of 200 mg, by means of pulsed Doppler velocimetry of the brachial artery and strain gauge mercury-in silastic plethysmography of the forearm. In add...<br/><br/>A Simon, J Levenson, J Bouthier, I Merli (1986) <i>J Pharmacol</i> <i></i> <i></i> 17: 3 331-337<br/>

http://publicationslist.org/alain.simon/refid242 2008-02-23T18:06:19Z

Fluid volumes and cardiac and renal hemodynamics were investigated in 44 obese men, 22 with normal blood pressure and 22 with sustained essential hypertension. For the same degree of obesity hypertensive patients had a higher value in extracellular (p less than 0.05) and interstitial fluid (p less than 0.01) volumes than normotensive subjects, while plasma volume, total body water, body cellular w...<br/><br/>J Raison, A Achimastos, R Asmar, A Simon, M Safar (1986) <i>Am J Cardiol</i> <i></i> <i></i> 57: 4 223-226<br/>

http://publicationslist.org/alain.simon/refid243 2008-02-23T18:06:19Z

The haemodynamic pattern of the common carotid artery was studied before and after administration of captopril isosorbide dinitrate and nitrendipine, in men with sustained essential hypertension. Pulsed Doppler methods were used. Captopril produced both a fall in vascular resistance and an increase in the arterial diameter of the common carotid artery. Thus, in the common carotid artery circulatio...<br/><br/>M E Safar, J A Bouthier, S M Laurent, A C Simon (1986) <i>Postgrad Med J</i> <i></i> <i></i> 62 Suppl 1: 31-33<br/>

http://publicationslist.org/alain.simon/refid222 2008-02-23T18:06:19Z

Arterial diameter, blood velocity and blood flow of both common carotid arteries were studied in 24 patients with isolated unilateral internal carotid artery stenosis, without any other significant lesion of the carotid system. The methodology used a pulsed Doppler system with two original characteristics: an adjustable range-gated system and a double transducer probe enabling both the arterial di...<br/><br/>A Benetos, A Simon, J Levenson, P Lagneau, J Bouthier, M Safar (1985) <i>Stroke</i> <i></i> <i></i> 16: 6 969-972<br/>

http://publicationslist.org/alain.simon/refid221 2008-02-23T18:06:19Z

The central and peripheral haemodynamic effects of the administration of 10 mg nifedipine sublingually in 6 patients with essential hypertension were compared with those observed after the administration of one 20 mg slow release tablet of nifedipine in 7 other hypertensive patients of the same age. The circulatory effects in the forearm were studied by pulsed Doppler velocimetry which allowed sim...<br/><br/>J Levenson, A C Simon, J D Bouthier, B C Maarek, M E Safar (1985) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 78 Spec No: 33-39<br/>

http://publicationslist.org/alain.simon/refid223 2008-02-23T18:06:19Z

A Simon, J Levenson, J Bouthier, M Safar (1985) <i>Therapie</i> <i></i> <i></i> 40: 6 397-401<br/>

http://publicationslist.org/alain.simon/refid226 2008-02-23T17:58:42Z

The forearm arterial effects of enalapril and propranolol were compared by means of pulsed Doppler velocimetry in 28 patients with hypertension after treatment for 3-6 months. Enalapril decreased blood pressure, increased both brachial artery diameter and blood flow, decreased vascular resistance, and increased the arterial compliance of the forearm. Propranolol also decreased blood pressure but d...<br/><br/>A C Simon, J Levenson, J D Bouthier, M E Safar (1985) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 7: 5 856-861<br/>

http://publicationslist.org/alain.simon/refid233 2008-02-23T17:58:42Z

In patients with essential hypertension, vasodilating antihypertensive drugs act differently on small and large arteries. For similar blood pressure reductions, the diameter of the brachial artery may be unchanged (alpha- and beta-blocking drugs), decreased (dihydralazine), or increased (nitrates, renin-angiotensin and calcium-entry inhibitors). Increase in blood flow is due preferentially to an i...<br/><br/>J A Levenson, A C Simon, M E Safar (1985) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 7 Suppl 2: S115-S120<br/>

http://publicationslist.org/alain.simon/refid244 2008-02-23T18:06:19Z

The large arteries are impaired in uncomplicated, permanent, essential arterial hypertension. The peripheral arteries such as the humeral artery or the common carotid artery have a normal or increased diameter, reduced blood flow and, especially, reduced compliance. Reduction of the arterial compliance reflects an impairment peculiar to the large blood vessels, independent of the pressure. Antihyp...<br/><br/>J Bouthier, C Hugue, R Asmar, A Simon, M Safar (1985) <i>Ann Cardiol Angeiol (Paris)</i> <i></i> <i></i> 34: 10 693-696<br/>

http://publicationslist.org/alain.simon/refid245 2008-02-23T17:58:42Z

Determinations of central venous pressure, cardiac haemodynamics and rapid volume expansion using iso-oncotic dextran were made in 49 men with sustained, uncomplicated essential hypertension and compared with those in 27 normotensive subjects of the same age and sex. In the hypertensives, central venous pressure was significantly increased in basal conditions while the cardiac index was normal and...<br/><br/>G M London, M E Safar, A L Safar, A C Simon (1985) <i>J Hypertens</i> <i></i> <i></i> 3: 4 337-342<br/>

http://publicationslist.org/alain.simon/refid246 2008-02-23T17:58:42Z

Echocardiographic determinations, left ventricular mass-volume ratio (M/V), left ventricular end-systolic stress (ESS), carotidofemoral pulse wave velocity (PWV), and brachial artery compliance (BAC), deduced from pulsed Doppler measurements and from the Bramwell-Hill equation, were evaluated in 20 patients with sustained essential hypertension in comparison with 20 control subjects of the same ag...<br/><br/>J D Bouthier, N De Luca, M E Safar, A C Simon (1985) <i>Am Heart J</i> <i></i> <i></i> 109: 6 1345-1352<br/>

http://publicationslist.org/alain.simon/refid232 2008-02-23T17:58:42Z

Using noninvasive measurements of arterial diameter, compliance, and distensibility permits the mechanisms of increased systolic pressure in hypertensive humans to be better understood. Reduced arterial compliance causing a disproportionate increase in systolic pressure is a characteristic feature not only of pure systolic hypertension in the elderly but also of sustained essential systolodiastoli...<br/><br/>A C Simon, J A Levenson, M E Safar (1985) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 7 Suppl 2: S22-S27<br/>

http://publicationslist.org/alain.simon/refid231 2008-02-23T17:58:42Z

Diameter, blood flow velocity, and volumic flow of the common carotid artery were measured in 38 patients with sustained essential hypertension and compared with those of 38 age-matched normal subjects. Both hypertensive and control subjects were classified according to age into those younger and those older than 45 years. For the determinations, a pulsed Doppler velocimeter with an adjustable ran...<br/><br/>J Bouthier, A Benetos, A Simon, J Levenson, M Safar (1985) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 7 Suppl 2: S99-104<br/>

http://publicationslist.org/alain.simon/refid227 2008-02-23T17:58:42Z

Simultaneous determinations of cardiac output and brachial arterial blood flow were performed in patients with hypertension and high cardiac output in comparison with normal subjects of the same age. Brachial arterial blood flow was measured with a previously described pulsed Doppler apparatus that permitted the noninvasive determination of arterial diameter and blood flow velocity. In patients wi...<br/><br/>J Levenson, A C Simon, M E Safar, J D Bouthier, G M London (1985) <i>Circulation</i> <i></i> <i></i> 71: 4 663-668<br/>

http://publicationslist.org/alain.simon/refid228 2008-02-23T17:58:42Z

By using simultaneous recording curves obtained with pulsed Doppler velocimetry and strain gauge mechanography, forearm arterial haemodynamics were studied in 26 patients with mild to moderate essential hypertension. Fifteen patients received a single oral dose of nicardipine 40 mg, and 11 patients were treated with nicardipine 30 mg three times daily for 3 months. In both groups of patients there...<br/><br/>J Levenson, A C Simon, J Bouthier, B C Maarek, M E Safar (1985) <i>Br J Clin Pharmacol</i> <i></i> <i></i> 20 Suppl 1: 107S-113S<br/>

http://publicationslist.org/alain.simon/refid229 2008-02-23T17:58:42Z

Simultaneous brachial artery pressure and blood flow measurements were made in 15 patients with arteriosclerosis of the lower limbs (AOLL) and in controls of the same age and sex. Blood flow was evaluated by a pulsed Doppler device with a double-transducer probe. From analysis of the pressure-flow curves during diastole, regional arterial compliance (RAC) was determined by using as a model of the ...<br/><br/>J A Levenson, A C Simon, B E Maarek, R J Gitelman, J N Fiessinger, M E Safar (1985) <i>Arteriosclerosis</i> <i></i> <i></i> 5: 1 80-87<br/>

http://publicationslist.org/alain.simon/refid230 2008-02-23T17:58:42Z

The effects of angiotensin-converting enzyme inhibition on large arteries have been examined in uncomplicated essential hypertensive patients (grade 1-2 WHO). These effects were determined from (a) changes in arterial compliance as measured from the slope of the decline in arterial pressure during diastole and (b) alterations in diameter of the brachial artery and blood flow velocity within its lu...<br/><br/>A C Simon, J A Levenson, J Bouthier, B Maarek, M E Safar (1985) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 7 Suppl 1: S45-S51<br/>

http://publicationslist.org/alain.simon/refid225 2008-02-23T17:58:42Z

Noninvasive evaluation of brachial artery diameter (pulsed Doppler velocimetry) and pulse wave velocity (strain gauge mechanography) was performed in 23 normal subjects and 49 patients with uncomplicated essential hypertension. Pulsatile arterial function was described in terms of derived characteristic impedance and arterial compliance. Compared with normal controls, hypertensive patients had gre...<br/><br/>A C Simon, J Levenson, J Bouthier, M E Safar, A P Avolio (1985) <i>Hypertension</i> <i></i> <i></i> 7: 5 675-680<br/>

http://publicationslist.org/alain.simon/refid224 2008-02-23T18:06:19Z

The non invasive investigation of the brachial artery was performed in 51 mild to moderate essential hypertensive patients and 23 normal subjects of similar age. It included quantitative evaluation of arterial diameter (pulsed Doppler velocimetry), pulse wave velocity (strain gauge mechanography) and arterial compliance deduced from the former indices. Hypertensive patients exhibited higher pulse ...<br/><br/>A Simon, J Levenson, J Bouthier, B Maarek, M Safar (1985) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 78: 11 1720-1724<br/>

http://publicationslist.org/alain.simon/refid292 2008-02-23T17:58:42Z

Extracellular fluid volume (ECF), plasma volume (PV), glomerular filtration rate (GFR), renal plasma flow (RPF), efferent arteriolar oncotic pressure (pi E), sodium output (UNaV), and sodium clearance (CNa) were determined in 150 men including 50 normal controls (NC) and 100 sustained essential hypertensive patients (EH). Total effective vascular compliance (TEVC) and central venous pressure (CVP)...<br/><br/>G M London, J A Levenson, A M London, A C Simon, M E Safar (1984) <i>Kidney Int</i> <i></i> <i></i> 26: 3 342-350<br/>

http://publicationslist.org/alain.simon/refid293 2008-02-23T17:58:42Z

Arterial compliance was determined in eight normal subjects and 23 patients with hypertension and vascular disease by two independent techniques: (a) with a plethysmographic strain gauge (to measure pulsatile forearm volume changes as representing intra-arterial volume changes) and an automated sphygmomanometric system (to measure pulse pressure) and (b) calculation from the local pulse wave veloc...<br/><br/>D Fitchett, J D Bouthier, A C Simon, J A Levenson, M E Safar (1984) <i>Clin Sci (Lond)</i> <i></i> <i></i> 67: 1 69-72<br/>

http://publicationslist.org/alain.simon/refid291 2008-02-23T17:58:42Z

Cardiac output (CO), renal blood flow (RBF), calf blood flow (CBF), and hepatic blood flow (HBF), glomerular filtration rate (GFR), and dopamine beta hydroxylase (D beta H) activity were studied in 198 men (67 normotensive controls and 131 hypertensive patients) of the same age with sustained uncomplicated essential hypertension. In the hypertensive men, the RBF and the RBF/CO ratio were significa...<br/><br/>G M London, M E Safar, J E Sassard, J A Levenson, A C Simon (1984) <i>Hypertension</i> <i></i> <i></i> 6: 5 743-754<br/>

http://publicationslist.org/alain.simon/refid234 2008-02-23T17:58:42Z

The physical properties of intact superficial arteries can be studied in humans by using original pulsed Doppler systems. Measurements of the diameter, blood flow velocity, volumic flow, and compliance of the brachial artery can be obtained in hypertensive humans in comparison with controls of the same age. In sustained essential hypertension, arterial compliance is decreased, in a manner that is ...<br/><br/>M E Safar, A C Simon, J A Levenson (1984) <i>Hypertension</i> <i></i> <i></i> 6: 6 Pt 2 III117-III121<br/>

http://publicationslist.org/alain.simon/refid235 2008-02-23T17:58:42Z

A study of forearm arterial and venous hemodynamics by pulsed Doppler velocimetry and plethysmography was performed in 21 patients with essential hypertension, aged 16 to 54 years, before and after short-term nadolol administration at a dose of 0.05 mg/kg. Because of a large intersubject variability in the responses of the hemodynamic parameters to nadolol, an unconventional statistic approach was...<br/><br/>J Levenson, A C Simon, D Moyse, J Bouthier, M E Safar (1984) <i>Am Heart J</i> <i></i> <i></i> 108: 4 Pt 2 1177-1182<br/>

http://publicationslist.org/alain.simon/refid295 2008-02-23T17:58:42Z

The efficacy of MK 421 and propranolol was compared in 48 patients with mild to moderate hypertension. Each patient was randomly assigned to receive 1 of the drugs for 12 weeks. Additionally, a subgroup of 28 patients underwent studies of forearm arterial and venous circulation by means of pulsed Doppler and mercury-in-silastic plethysmography. Both drugs reduced supine and standing blood pressure...<br/><br/>A C Simon, J A Levenson, J D Bouthier, A Benetos, A Achimastos, M Fouchard, B C Maarek, M E Safar (1984) <i>Am J Cardiol</i> <i></i> <i></i> 53: 6 781-785<br/>

http://publicationslist.org/alain.simon/refid294 2008-02-23T17:58:42Z

The effect on large arteries of the converting enzyme inhibitor captopril was studied in men with sustained essential hypertension with two different hemodynamic parameters: (1) systemic arterial compliance and (2) brachial artery diameter. After captopril administration, a 20 percent increase in arterial compliance was observed. The same increase was obtained with a 5 percent (acute experiment) a...<br/><br/>A C Simon, J A Levenson, J L Bouthier, M E Safar (1984) <i>Am J Med</i> <i></i> <i></i> 76: 5B 71-75<br/>

http://publicationslist.org/alain.simon/refid298 2008-02-23T17:58:42Z

Brachial artery haemodynamics, including arterial diameter, blood flow velocity, blood flow and compliance of the brachial artery may be evaluated non-invasively in man, using pulsed Doppler methods. In patients with sustained untreated essential hypertension, brachial artery diameter is increased, blood flow is normal and arterial compliance is reduced independently of the level of blood pressure...<br/><br/>A C Simon, J A Levenson, A M Safar, J D Bouthier, M E Safar (1984) <i>Br J Clin Pharmacol</i> <i></i> <i></i> 18 Suppl 2: 243S-247S<br/>

http://publicationslist.org/alain.simon/refid299 2008-02-23T17:58:42Z

Acute effects of a new calcium entry blocker, nitrendipine, on large arteries of the forearm were studied by using arterial pulse strain gauge mecanography and pulsed Doppler velocimetry of the brachial artery in 13 mild to moderate essential hypertensive patients. Ninety minutes after nitrendipine ingestion, patients exhibited significant decreases in blood pressure without changes in heart rate;...<br/><br/>J Levenson, A C Simon, M E Safar, J Bouthier, B C Maarek (1984) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 6 Suppl 7: S1006-S1010<br/>

http://publicationslist.org/alain.simon/refid297 2008-02-23T17:58:42Z

G L London, J A Levenson, A C Simon, A M London, M E Safar (1984) <i>Neth J Med</i> <i></i> <i></i> 27: 4 112-116<br/>

http://publicationslist.org/alain.simon/refid296 2008-02-23T17:58:42Z

Central (six patients) and brachial (12 patients) haemodynamics were studied in men with sustained essential hypertension before and after intravenous administration of an alpha post-synaptic adrenergic blocking drug, urapidil. Brachial arterial compliance was evaluated non-invasively from the simultaneous measurement of pulse wave velocity and arterial diameter. In basal conditions, arterial comp...<br/><br/>J Levenson, A C Simon, J D Bouthier, A Benetos, M E Safar (1984) <i>J Hypertens</i> <i></i> <i></i> 2: 1 37-41<br/>

http://publicationslist.org/alain.simon/refid110 2008-02-23T17:58:42Z

Thromboxane B2 (TxB2) was measured in the venous and arterial plasma and in the urine of 15 borderline and 15 sustained essential hypertensive patients, and in the plasma and urine of 12 control normotensive age-matched subjects. Plasma and urine thromboxane B2 were significantly higher in both the borderline and sustained hypertensives than in the control normotensives. There was a significant po...<br/><br/>A Hornych, M Safar, J Bariéty, A Simon, G London, J Levenson (1983) <i>Prostaglandins Leukot Med</i> <i></i> <i></i> 10: 2 145-155<br/>

http://publicationslist.org/alain.simon/refid101 2008-02-23T17:58:42Z

Arteriovenous fistula (AVF) blood flow was evaluated in 32 dialysis patients using a pulsed Doppler velocimeter with two dominant features: a range-gated time system and a double transducer probe. With the proposed apparatus, the observation angle between the ultrasound beam and the vessel axis was known. In radial AVF, blood flow was 728 +/- 53 ml/min and was negatively correlated with the age of...<br/><br/>J D Bouthier, J A Levenson, A C Simon, J M Bariety, P E Bourquelot, M E Safar (1983) <i>Artif Organs</i> <i></i> <i></i> 7: 4 404-409<br/>

http://publicationslist.org/alain.simon/refid108 2008-02-23T17:58:42Z

Cardiac hemodynamics, diameter, blood flow velocity, and volumic flow of the brachial artery were studied before and after diltiazem administration in 11 patients with sustained essential hypertension. The study was compared with the hemodynamic effects of dihydralazine. The caliber of the brachial artery was evaluated with a pulsed Doppler velocimeter enabling the determination of the angle betwe...<br/><br/>M E Safar, A C Simon, J A Levenson, J L Cazor (1983) <i>Circ Res</i> <i></i> <i></i> 52: 2 Pt 2 I169-I173<br/>

http://publicationslist.org/alain.simon/refid102 2008-02-23T17:58:42Z

Hemodynamic variables were measured in 34 patients with isolated systolic hypertension before and after acute administration of propranolol. The patients were separated into two groups, those younger than and those older than 45 years of age, respectively. After drug administration, systolic pressure decreased significantly (P less than 0.001) in younger subjects with a concomitant increase in rap...<br/><br/>J Levenson, A Simon, B Maarek, J Totomoukouo, R Gitelman, J Bouthier, M Safar (1983) <i>Eur Heart J</i> <i></i> <i></i> 4 Suppl G: 51-54<br/>

http://publicationslist.org/alain.simon/refid107 2008-02-23T17:58:42Z

Simultaneous brachial artery pressure and blood flow measurements were made in 45 men. Blood flow was evaluated by means of a pulsed Doppler device with a double transducer probe. From analysis of the pressure-flow curves during diastole, forearm arterial compliance (FAC) was determined by using the model of the forearm arterial tree as a system of tubes, each with a storage capacitance, in series...<br/><br/>A C Simon, S Laurent, J A Levenson, J E Bouthier, M E Safar (1983) <i>Cardiovasc Res</i> <i></i> <i></i> 17: 6 331-338<br/>

http://publicationslist.org/alain.simon/refid104 2008-02-23T17:58:42Z

Since systolic pressure is governed by the rate of ventricular ejection and the rigidity of the aortic wall, antihypertensive agents may have different effects on systolic and diastolic pressure. Despite an adequate decrease in diastolic pressure, systolic pressure may remain elevated due to structural alterations of large arteries. In the present study, a procedure is described to distinguish the...<br/><br/>M E Safar, J A Bouthier, J A Levenson, A C Simon (1983) <i>Hypertension</i> <i></i> <i></i> 5: 5 Pt 2 III63-III68<br/>

http://publicationslist.org/alain.simon/refid109 2008-02-23T17:58:42Z

Blood pressure, heart rate, and arterial diameter of the brachial artery were studied in patients with sustained essential hypertension before and after administration of three vasodilating drugs: dihydralazine, diltiazem, and dinitrate isosorbide (ISDN). The diameter of the brachial artery was measured using a pulsed Doppler device, enabling the angle between the ultrasound beam and the vessel ax...<br/><br/>J A Levenson, M E Safar, J E Bouthier, A M Benetos, A C Simon (1983) <i>Chest</i> <i></i> <i></i> 83: 2 Suppl 325-327<br/>

http://publicationslist.org/alain.simon/refid300 2008-02-23T17:58:42Z

Systemic and arterial hemodynamic effects of the new 20 mg tablet of nifedipine were studied in seven patients with mild-to-moderate essential hypertension. Hemodynamics of the forearm arterial circulation were investigated using a new pulsed Doppler system, enabling the simultaneous determination of the brachial artery diameter and the arterial blood flow velocity. After nifedipine administration...<br/><br/>J A Levenson, M E Safar, A C Simon, J A Boutier, L Griener (1983) <i>Hypertension</i> <i></i> <i></i> 5: 6 Pt 3 V57-V60<br/>

http://publicationslist.org/alain.simon/refid106 2008-02-23T17:58:42Z

We studied blood pressure, arterial diameter, and blood flow of the brachial artery in patients with sustained essential hypertension before and after administration of the vasodilating drugs nitroglycerin, captopril, dihydralazine, diltiazem, and isosorbide dinitrate (ISDN). The diameter and the blood flow of the brachial artery were measured with a pulsed Doppler device which allowed the angle b...<br/><br/>A C Simon, M E Safar, J A Levenson, J E Bouthier, A Benetos (1983) <i>J Cardiovasc Pharmacol</i> <i></i> <i></i> 5: 4 626-631<br/>

http://publicationslist.org/alain.simon/refid248 2008-02-23T17:58:42Z

A Hornych, M Safar, A Simon, J Bariéty (1983) <i>Adv Prostaglandin Thromboxane Leukot Res</i> <i></i> <i></i> 11: 417-422<br/>

http://publicationslist.org/alain.simon/refid105 2008-02-23T17:58:42Z

Central and forearm arterial and venous hemodynamics, arterial baroreflex sensitivity, plasma renin activity, and catecholamines were studied in supine position and after -10 degrees head-down tilt in 29 patients with sustained essential hypertension and in 29 normotensive controls of the same age and sex. In both populations, blood pressure, heart rate, and arterial baroreflex sensitivity did not...<br/><br/>G M London, J A Levenson, M E Safar, A C Simon, A P Guerin, D Payen (1983) <i>Am J Physiol</i> <i></i> <i></i> 245: 2 H194-H202<br/>

http://publicationslist.org/alain.simon/refid247 2008-02-23T17:58:42Z

A Simon, M Safar, J Labouret, J N Fiessinger (1983) <i>Rev Med Interne</i> <i></i> <i></i> 4: 1 7-9<br/>

http://publicationslist.org/alain.simon/refid103 2008-02-23T17:58:42Z

The efficacy of MK-421 was compared with that of propranolol in patients with mild to moderate essential hypertension, using a placebo-controlled double-blind randomized protocol. The two drugs reduced supine and standing blood pressures, but propranolol, unlike MK-421, reduced heart rate. Using a pulsed Doppler method, brachial artery diameter, blood velocity and blood flow were measured during t...<br/><br/>J A Levenson, M E Safar, A C Simon, B E Maarek (1983) <i>J Hypertens Suppl</i> <i></i> <i></i> 1: 1 101-102<br/>

http://publicationslist.org/alain.simon/refid117 2008-02-23T17:58:42Z

The antihypertensive, renal and hormonal effects of captopril were studied in 10 patients with essential hypertension. Captopril significantly decreased arterial blood pressure with a concomitant increase in glomerular filtration rate, natriuresis and kaliuresis and a significant selective increase in urinary (renal) prostaglandin E2; other plasma and urinary prostaglandin (F2 alpha, 6-keto-prosta...<br/><br/>A Hornych, M Safar, A Simon, J Levenson, J Bariety, P Milliez (1982) <i>Am J Cardiol</i> <i></i> <i></i> 49: 6 1524-1526<br/>

http://publicationslist.org/alain.simon/refid249 2008-02-23T17:58:42Z

Thromboxane A2 (TxA2) is a vasoconstrictor synthetized by the kidney. Its role in hypertension is unknown. We measured urinary TxB2 (the metabolite of renal TxA2) by radioimmunoassay and studied renal functions in 15 borderline, 15 sustained essential hypertensive patients and 12 age-matched normotensive subjects (6 young and 6 older adults). Results were as follows: Normotensive subjects: Mean ar...<br/><br/>A Hornych, M Safar, J Bariéty, A Simon, C Krief, P Milliez (1982) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 75 Spec No: 109-113<br/>

http://publicationslist.org/alain.simon/refid250 2008-02-23T17:58:42Z

Plasma aldosterone (PA), plasma renin activity (PRA), extracellular fluid volume (EFV) and hepatic blood flow were measured in forty-four patients with sustained essential hypertension and compared with forty-two normotensive controls of same age and sex. All patient had inulin clearances within the normal range and balanced sodium intake and urinary output. In hypertensives, PA, PRA, EFV and hepa...<br/><br/>M E Safar, A C Simon, S A Dard, H R Parlier, N E Pauleau, M L Vincent, J E Sassard (1982) <i>Clin Endocrinol (Oxf)</i> <i></i> <i></i> 16: 1 77-88<br/>

http://publicationslist.org/alain.simon/refid116 2008-02-23T17:58:42Z

Hemodynamic parameters and systemic arterial compliance were measured in patients with arteriosclerosis obliterans of the lower limbs before and after acute administration of propranolol. Arterial compliance was evaluated from a simple viscoelastic model, enabling the calculation of diastolic drainage and diastolic blood flow as indices of the reservoir role of the larger arteries in overall circu...<br/><br/>J A Levenson, A C Simon, J N Fiessinger, M E Safar, G M London, E M Housset (1982) <i>Arteriosclerosis</i> <i></i> <i></i> 2: 3 266-271<br/>

http://publicationslist.org/alain.simon/refid114 2008-02-23T17:58:42Z

Cardiac hemodynamic and diameter, blood flow velocity, volumic flow of the brachial artery measured by pulsed Doppler, were studied before and after diltiazem administration in comparison with dihydralazine in hypertensive patients. After diltiazem administration, blood pressure and total peripheral resistance significantly decreased (P less than 0.001) while cardiac index and heart rate increased...<br/><br/>J Levenson, A Simon, A Achimastos, M Temmar, M Safar (1982) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 75 Spec No: 167-170<br/>

http://publicationslist.org/alain.simon/refid112 2008-02-23T17:58:42Z

1 Blood pressure, systemic arterial compliance, and diameter, blood flow velocity, volumic flow and impedance of the brachial artery were measured before and after intravenous administration of nitroglycerin (15 micrograms/min during 15 min) in 11 patients with sustained essential hypertension. 2 For the evaluation of the diameter of the brachial artery, a bidimensional pulsed Doppler was used, en...<br/><br/>A C Simon, J A Levenson, B Y Levy, J E Bouthier, P P Peronneau, M E Safar (1982) <i>Br J Clin Pharmacol</i> <i></i> <i></i> 14: 2 241-246<br/>

http://publicationslist.org/alain.simon/refid113 2008-02-23T17:58:42Z

The pharmacokinetics of intravenous isosorbide dinitrate was investigated in 11 patients with labile hypertension and with normal renal and hepatic functions. The mode of administration (constant rate infusion without loading dose) was chosen in order to minimize side-effects and to approximate clinical conditions. Isosorbide dinitrate levels were measured by electron-capture gas chromatography. T...<br/><br/>A Frydman, J Levenson, A Simon, M Safar, A Bieder, J Bertharion, J Gaillot (1982) <i>Nouv Presse Med</i> <i></i> <i></i> 11: 27 2049-2056<br/>

http://publicationslist.org/alain.simon/refid111 2008-02-23T17:58:42Z

A C Simon, J A Levenson, M E Safar (1982) <i>Eur Heart J</i> <i></i> <i></i> 3 Suppl C: 65-69<br/>

http://publicationslist.org/alain.simon/refid115 2008-02-23T17:58:42Z

Hemodynamic parameters were measured in 24 patients with arteriosclerosis obliterans of the lower limbs, in comparison with 16 normal subjects of same age. Systemic arterial compliance was estimated from a simple visco-elastic model. In patients with arteriosclerosis obliterans, systolic pressure was significantly increased (P less than 0.001) while diastolic pressure remained within normal ranges...<br/><br/>M Temmar, A Benetos, A Simon, J N Fiessinger, J Levenson, M Safar (1982) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 75 Spec No: 163-166<br/>

http://publicationslist.org/alain.simon/refid119 2008-02-23T17:58:42Z

Hemodynamic parameters were measured in 24 patients with arteriosclerosis obliterans of the lower limbs (AOLL) in comparison with 16 normal subjects of same age. Systemic artérial compliance was estimated from a simple visco-elastic model. In patients with (AOLL), systolic pressure was significantly increased (P less than 0.001) while diastolic pressure remained within normal ranges. Arterial com...<br/><br/>J A Levenson, A C Simon, M E Safar, J N Fiessinger, E M Housset (1982) <i>Clin Exp Hypertens A</i> <i></i> <i></i> 4: 7 1059-1072<br/>

http://publicationslist.org/alain.simon/refid118 2008-02-23T17:58:42Z

Plasma prostaglandins PGE2 and PGF2 alpha, cardiac hemodynamics, total effective vascular compliance, plasma (PV), interstitial (IFV) and extracellular fluid volumes, and renal indices were determined in 13 men with either borderline or sustained essential hypertension. PGE2 measured in the central venous blood was increased in borderline and in sustained hypertensives (p less than 0.01), while PG...<br/><br/>G M London, A Hornych, M E Safar, J A Levenson, A C Simon (1982) <i>Nephron</i> <i></i> <i></i> 32: 2 118-124<br/>

http://publicationslist.org/alain.simon/refid125 2008-02-23T17:58:42Z

M E Safar, P A Peronneau, J A Levenson, J A Toto-Moukouo, A C Simon (1981) <i>Circulation</i> <i></i> <i></i> 63: 2 393-400<br/>

http://publicationslist.org/alain.simon/refid126 2008-02-23T17:58:42Z

M E Safar, A C Simon, J A Levenson (1981) <i>Acquis Med Recent</i> <i></i> <i></i> 198: 223-226<br/>

http://publicationslist.org/alain.simon/refid123 2008-02-23T17:58:42Z

Systemic arterial compliance was estimated in 31 men, including 15 patients with sustained essential hypertension and 16 normal subjects of the same age. Values were derived from analysis of the monoexponential blood pressure-time curve during diastole, according to a simple viscoelastic model. In normal subjects, baseline arterial compliance was 2.56 +/- 0.18 ml/mm Hg. A significant decrease (1.8...<br/><br/>J A Levenson, M E Safar, A C Simon, A I Kheder, J N Daou, B I Levy (1981) <i>Angiology</i> <i></i> <i></i> 32: 6 402-413<br/>

http://publicationslist.org/alain.simon/refid124 2008-02-23T17:58:42Z

A pulsed Doppler velocimeter suitable for the determination of blood flow velocity and volumic flow in peripheral arteries is described. The apparatus has two main characteristics: an adjustable range-gated time system and a double transducer probe. The error in the determination of the angle between the ultrasound beam and flow of blood with this apparatus was less than 2%, and overestimation of ...<br/><br/>J A Levenson, P A Peronneau, A Simon, M E Safar (1981) <i>Cardiovasc Res</i> <i></i> <i></i> 15: 3 164-170<br/>

http://publicationslist.org/alain.simon/refid121 2008-02-23T17:58:42Z

Extracellular fluid volume, hemodynamic parameters, total effective compliance, and renal indices were measured in 58 patients with sustained essential hypertensive in comparison with 56 normotensive subjects of the same age and sex. All subjects had a balanced sodium intake and urinary output with inulin clearance and extracellular fluid volume within normal ranges. In patients with hypertension,...<br/><br/>G M London, M E Safar, J A Levenson, A C Simon, M A Temmar (1981) <i>Kidney Int</i> <i></i> <i></i> 20: 1 97-103<br/>

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1. In basal conditions, plasma arterial prostaglandin (PG) E2 was significantly increased in borderline hypertensive patients (BH) (28.5 +/- 6.7 pg/ml) in comparison with sustained essential hypertensive patients (EH) (11.6 +/- 3.2 pg/ml) and in comparison with control normotensive subjects (NTS) (5.8 +/- 1.4 pg/ml). 2. Plasma arterial PGE2 was positively significantly correlated with cardiac inde...<br/><br/>M E Safar, A F Hornych, J A Levenson, A C Simon, G M London, J L Bariéty, P L Milliez (1981) <i>Clin Sci (Lond)</i> <i></i> <i></i> 61 Suppl 7: 323s-325s<br/>

http://publicationslist.org/alain.simon/refid122 2008-02-23T17:58:42Z

1. Cardiac output, lower-limb blood flow, hepatic and renal blood flows were studied in 16 patients with borderline and 16 patients with sustained essential hypertension and compared with 16 age-matched control subjects. 2. In borderline hypertension cardiac output and lower-limb blood flow were significantly elevated, while hepatic and renal blood flows were within the normal range. Cardiac outpu...<br/><br/>M M Temmar, M E Safar, J A Levenson, J M Totomoukouo, A C Simon (1981) <i>Clin Sci (Lond)</i> <i></i> <i></i> 60: 6 653-658<br/>

http://publicationslist.org/alain.simon/refid132 2008-02-23T17:58:42Z

Plasma renin activity and extracellular fluid volume were determined in 34 normotensive and in 35 sustained essential hypertensive patients with normal renal function, balanced sodium intake and urinary output. In normotensives, plasma renin activity was negatively correlated to extracellular fluid volume (r = 0.54; p = 0.001). The 95% confidence limits of the normotensive curve was used as nomogr...<br/><br/>J A Levenson, M E Safar, J E Sassard, A C Simon, M L Vincent, J L Temmar, J M Alexandre (1980) <i>Nephron</i> <i></i> <i></i> 25: 5 238-242<br/>

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M Safar, A Simon, A Pipeau (1980) <i>Nouv Presse Med</i> <i></i> <i></i> 9: 10 677-679<br/>

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A Hornych, G London, M Safar, Y Weiss, A Simon, T T Guyene, J Bariéty, P Milliez (1980) <i>Adv Prostaglandin Thromboxane Res</i> <i></i> <i></i> 7: 1119-1122<br/>

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M Safar, A C Simon, J A Levenson (1980) <i>Acquis Med Recent</i> <i></i> <i></i> : 155-160<br/>

http://publicationslist.org/alain.simon/refid131 2008-02-23T17:58:42Z

J A Levenson, E Roland, J Toto Mou Kouo, A Simon, M Safar (1980) <i>Rev Med Interne</i> <i></i> <i></i> 1: 1 123-126<br/>

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Hemodynamic parameters were studied before and after administration of SQ 14 225, an orally active converting enzyme inhibitor, in 6 sustained essential hypertensive patients. Blood pressure and total peripheral resistance significantly decreased while cardiac output and heart rate remained unchanged. Systolic time intervals and plasma volume were not modified. No correlation was observed between ...<br/><br/>J Levenson, A Simon, M Temmar, M Safar (1980) <i>Nouv Presse Med</i> <i></i> <i></i> 9: 9 617-619<br/>

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1. Cardiac haemodynamics were studied in 14 male patients with phaeochromocytoma, in comparison with 33 normal male subjects and 65 males with essential hypertension. 2. At the time of investigation, seven patients with phaeochromocytoma were hypertensive and seven were normotensive. Cardiac output was within normal limits. Total peripheral resistance was elevated in the hypertensive patients. Hea...<br/><br/>J A Levenson, M E Safar, G M London, A C Simon (1980) <i>Clin Sci (Lond)</i> <i></i> <i></i> 58: 5 349-356<br/>

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A methodology for the determination of arterial compliance in men was developped. Arterial compliance was estimated from analysis of the monoexponential blood pressure-time curve during diastole, according to a simple visco-elastic model. Arterial compliance and indices of ventricular ejection were measured in patients with systolic hypertension. In the younger patients, arterial compliance and st...<br/><br/>M E Safar, J A Levenson, A M Kheder, A C Simon (1980) <i>Arch Int Pharmacodyn Ther</i> <i></i> <i></i> Suppl: 233-240<br/>

http://publicationslist.org/alain.simon/refid135 2008-02-23T17:58:42Z

Arterial compliance and indexes of ventricular ejection were measured in 27 men with systolic hypertension. The patients were separated into two age groups, younger or older than age 35 years, and matched with normotensive control subjects. Arterial compliance was estimated from analysis of the monoexponential blood pressure-time curve during diastole, according to a simple viscoelastic model. In ...<br/><br/>A C Simon, M A Safar, J A Levenson, A M Kheder, B I Levy (1979) <i>Am J Cardiol</i> <i></i> <i></i> 44: 3 505-511<br/>

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M Safar, A Simon, C Tzincoca, N Aboras, P Milliez (1979) <i>Ann Cardiol Angeiol (Paris)</i> <i></i> <i></i> 28: 1 31-34<br/>

http://publicationslist.org/alain.simon/refid136 2008-02-23T17:58:42Z

Hemodynamic and blood volume changes, systolic time intervals, and baroreflex mechanisms were studied in 20 patients with hypertension after methyldopa (12 +/- 0.9 mg/kg/day). The drug was administered orally during 7 days' hospitalization on a normal sodium diet (110 mEq/day). There was a fall in blood pressure and in total peripheral resistance, without significant change in cardiac index, heart...<br/><br/>M E Safar, G M London, J A Levenson, M A Kheder, N E Aboras, A C Simon (1979) <i>Clin Pharmacol Ther</i> <i></i> <i></i> 25: 3 266-272<br/>

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A Simon, J Levenson, A Kheder, M Safar (1979) <i>Acquis Med Recent</i> <i></i> <i></i> : 169-178<br/>

http://publicationslist.org/alain.simon/refid256 2008-02-23T17:58:42Z

Electrocardiographic finding were studied in 34 severe hypertensions submitted to antihypertensive therapy. The duration of the survey was between 2 and 6 years. No significant correlation was observed between the changes in pressure and the changes in electrocardiogramm: normalisation of blood pressure could be associated with abnormalities in the electrocardiogramm, concerning especially ST segm...<br/><br/>J F Blancher, H Ben-Mais, A Simon, N Aboras, A Kheder, M Safar (1979) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 72: 3 296-300<br/>

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Extracellular fluid volume (EFV), total blood volume (TBV), and renal indices were determined in 53 permanent essential hypertensive patients with normal renal function and balanced sodium intake and urinary output. In comparison with normal subjects, hypertensives had normal EFV values while TBV and the TBV/EFV ratio were significantly reduced (p less than 0.001). In hypertensives, a significant ...<br/><br/>A C Simon, M E Safar, J A Levenson, N E Aboras, J M Alexandre, N F Pauleau (1979) <i>Clin Exp Hypertens</i> <i></i> <i></i> 1: 5 557-576<br/>

http://publicationslist.org/alain.simon/refid254 2008-02-23T17:58:42Z

Systolic time intervals, echocardiographic dimensions and hemodynamic parameters were determined in 42 borderline hypertensive patients with high cardiac output and 33 normal subjects. In borderline hypertensive patients, the preejection period was significantly reduced (P less than 0.001) and was negatively correlated to cardiac index (P less than 0.001). The interventricular septum thickness (IV...<br/><br/>J P Lehner, M E Safar, V M Dimitriu, A C Simon, J P Carrez, M T Plainfosse (1979) <i>Eur J Cardiol</i> <i></i> <i></i> 9: 4 319-331<br/>

http://publicationslist.org/alain.simon/refid133 2008-02-23T17:58:42Z

Cardiac output, blood pressure, and the characteristics of diastolic pressure decay were studied in 12 normal subjects and 23 sustained hypertensive patients of the same age. In normal subjects and in hypertensives, analysis of the diastolic decay showed that i) the form of the decay approximated a simple monoexponential curve during the last two-thirds of the diastolic segment, and ii) the time c...<br/><br/>A C Simon, M E Safar, J A Levenson, G M London, B I Levy, N P Chau (1979) <i>Am J Physiol</i> <i></i> <i></i> 237: 5 H550-H554<br/>

http://publicationslist.org/alain.simon/refid134 2008-02-23T17:58:42Z

Hemodynamic parameters were studied before and after rapid dextran infusion in 34 men including 17 patients with sustained essential hypertension and 17 normotensive controls. In both groups of patients, dextran infusion induced a significant increase (p less than 0.001) in central venous pressure (CVP), cardiac output (CO), and stroke volume. The percent change in stroke volume was significantly ...<br/><br/>M E Safar, G M London, J A Levenson, A C Simon, N P Chau (1979) <i>Hypertension</i> <i></i> <i></i> 1: 6 615-623<br/>

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Echocardiographic dimensions and hemodynamic indexes were determined in 42 patients with borderline hypertension and in 22 with sustained hypertension and the results were compared with findings in 33 normal subjects. In patients with borderline hypertension the thickness of the interventricular septum (IVS) was significantly increased (P less than 0.001), whereas the posterior wall PW) thickness ...<br/><br/>M E Safar, J P Lehner, M I Vincent, M T Plainfosse, A C Simon (1979) <i>Am J Cardiol</i> <i></i> <i></i> 44: 5 930-935<br/>

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Guanfacine kinetics were studied in 19 patients with hypertension after single and repeated oral doses. The single-dose study was performed in two homogeneous groups who received 2 mg (n = 9) and 4 mg (n = 10). The plasma concentrations were fitted in a two-compartment open model with first-order absorption. After a lag time of 0.8 hr, the absorption occurred rapidly (t 1/2 congruent to 0.53 hr). ...<br/><br/>Y A Weiss, D L Lavene, M E Safar, A C Simon, Y Loria, D R Georges, P L Milliez (1979) <i>Clin Pharmacol Ther</i> <i></i> <i></i> 25: 3 283-293<br/>

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Total effective vascular compliance, hemodynamic parameters, cardiopulmonary (CPBV) and total blood volumes (TBV) were determined in 31 men, including nine normotensive controls and 22 permanent essential hypertensive patients. The effective compliance was calculated from the changes in central venous pressure recorded simultaneously with the changes in blood volume obtained after a rapid dextran ...<br/><br/>G M London, M E Safar, Y A Weiss, C A Simon (1978) <i>Am Heart J</i> <i></i> <i></i> 95: 3 325-330<br/>

http://publicationslist.org/alain.simon/refid139 2008-02-23T17:58:42Z

1. The pharmacokinetics of intravenous and oral pindolol were determined in 24 hypertensive patients with normal or impaired renal function. 2. In patients with normal renal function, the total clearance of the drug was the sum of both the renal and non-renal clearances in equal parts. The non-renal clearance was found to equal the hepatic clearance directly measured from the hepatic extraction ra...<br/><br/>M E Safar, N P Chau, J A Levenson, A C Simon, Y A Weiss (1978) <i>Clin Sci Mol Med Suppl</i> <i></i> <i></i> 4: 275s-277s<br/>

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N P Chau, M E Safar, Y A Weiss, G M London, A C Simon, P L Milliez (1978) <i>Clin Sci Mol Med</i> <i></i> <i></i> 54: 2 175-180<br/>

http://publicationslist.org/alain.simon/refid143 2008-02-23T17:58:42Z

Repeat hemodynamic determinations were performed in 37 young men with borderline hypertension. The duration of the follow up study was 47 +/- three months. At each determination, those with borderline hypertension were compared to a group of matched normal subjects. Blood pressure increased from the first to the second determination, but the increase was significant only for systolic (P less than ...<br/><br/>Y A Weiss, M E Safar, G M London, A C Simon, J A Levenson, P M Milliez (1978) <i>Am J Med</i> <i></i> <i></i> 64: 3 382-387<br/>

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A Hornych, G London, M Safar, Y Weiss, A Simon, T T Guyene, J Bariéty, P Milliez (1978) <i>J Urol Nephrol (Paris)</i> <i></i> <i></i> 84: 12 843-849<br/>

http://publicationslist.org/alain.simon/refid140 2008-02-23T17:58:42Z

1 Hepatic blood flow was determined before and during (+)- and (+/-)-propranolol plasma concentration plateaus in 19 patients with suspected renal hypertension and normal liver function. 2 Hepatic blood flow significantly decreased (P less than 0.001) during (+/-)-propranolol administration and remained unchanged during (+)-propranolol administration. 3 Hepatic extraction ratio was 74 +/- 1% (+/-)...<br/><br/>Y A Weiss, M E Safar, J P Lehner, J A Levenson, A Simon, J M Alexandre (1978) <i>Br J Clin Pharmacol</i> <i></i> <i></i> 5: 5 457-460<br/>

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J P Lehner, A Kheder, J Levenson, A Simon, N Cadre, Y Weiss, M Safar (1978) <i>Coeur Med Interne</i> <i></i> <i></i> 17: 1 89-94<br/>

http://publicationslist.org/alain.simon/refid144 2008-02-23T17:58:42Z

The long terme hemodynamic effect of cyclothiazide 3 mg-triamterene 150 mg was studied in 10 patients with permanent essential hypertension. Diuretic therapy induced a significant fall in blood pressure (p less than 0.001) and total peripheral resistance (p less than 0.01), without significant change in cardiac index or blood volume. The result suggests that adaptative mechanisms of the circulator...<br/><br/>A Simon, M Safar, N Aboras, A Kheder, J Levenson, P Milliez (1978) <i>Nouv Presse Med</i> <i></i> <i></i> 7: 5 349-350<br/>

http://publicationslist.org/alain.simon/refid260 2008-02-23T17:58:42Z

Cardiac output (isotopic dilution method) and systolic time intervals were studied in 11 sustained and 8 borderline essential hypertensive patients, before and after intravenous administration of atenolol, a potent beta-blocking agent. Atenolol decreased significantly (p less than 0.01) cardiac output and heart rate. In borderline hypertensives, the preejection periods were significantly reduced. ...<br/><br/>J P Lehner, A Simon, A Kehder, Y Weiss, C Tzincoca, M Safar (1978) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 71: 10 1107-1112<br/>

http://publicationslist.org/alain.simon/refid262 2008-02-23T17:58:42Z

Hepatic blood flow and peripheral plasma renin activity were determined in 15 true renovascular hypertensive patients and in 13 patients with essential hypertension. In the renovascular hypertensives, plasma renin activity and hepatic blood flow were negatively correlated ( p less than 0.01). In contrast, no relationship was observed in the essential hypertensives. The study suggests that hyperact...<br/><br/>M E Safar, Y A Weiss, F M Fontaliran, A C Simon, N F Pauleau (1978) <i>Nephron</i> <i></i> <i></i> 20: 2 119-123<br/>

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E Roland, Y Weiss, A Simon, M Safar (1978) <i>Coeur Med Interne</i> <i></i> <i></i> 17: 4 585-603<br/>

http://publicationslist.org/alain.simon/refid141 2008-02-23T17:58:42Z

Systemic arterial compliance was measured in 22 patients with permanent essential hypertension and compared with 11 sex- and age-matched normal normal subjects. Determinations were made from analysis of the monoexponential blood pressure-time curve during diastole, according to a simple visco-elastic model. Arterial compliance was significantly decreased (P less than 0.001) in hypertensives. In th...<br/><br/>A C Simon, B I Levy, Y A Weiss, M A Kheder, J M Levenson, M E Safar (1978) <i>Angiology</i> <i></i> <i></i> 29: 5 402-409<br/>

http://publicationslist.org/alain.simon/refid142 2008-02-23T17:58:42Z

Total effective compliance, hemodynamic parameters, extracellular fluid volume, cardiopulmonary (CPBV) and total blood (TBV) volumes were determined in 32 men, including 14 normotensive controls and 18 sustained essential hypertensive patients. The effective compliance was calculated from the changes in central venous pressure recorded simultaneously with the changes in blood volume obtained after...<br/><br/>G M London, M E Safar, A C Simon, J M Alexandre, J A Levenson, Y A Weiss (1978) <i>Circulation</i> <i></i> <i></i> 57: 5 995-1000<br/>

http://publicationslist.org/alain.simon/refid263 2008-02-23T17:58:42Z

The decrease of sympathetic activity by the beta-blocking drug, as demonstrated by the decreased electric activity of the splanchnic nerve and by the decreased urinary catecholamine reponse to tilt as well as by the decreased levels of plasma dopamine beta-hydroxylase exists not only in hypertension with elevated PRA but also in hypertension with normal or low PRA. In these latter cases the antihy...<br/><br/>M Andrejak, J M Hardin, J M Alexandre, A Simon, A Fournier, M Safar, J Quichaud (1977) <i>Nouv Presse Med</i> <i></i> <i></i> 6: 44 4133-4137<br/>

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Baroreflex sensitivity and cardiopulmonary blood volume were determined in 95 men, including normotensive and hypertensive subjects with normal renal function and balanced sodium intake and urinary output. Baroreflex sensitivity was estimated by determining the slope of the regression line relating the increase of systolic pressure to the cardiac slowing after transient rises of arterial pressure....<br/><br/>A C Simon, M E Safar, Y A Weiss, G M London, P L Milliez (1977) <i>Br Heart J</i> <i></i> <i></i> 39: 7 799-805<br/>

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Correlates of plasma renin activity and plasma aldosterone levels with hemodynamic functions were studied in 47 male patients with untreated, permanent essential hypertension. All subjects had a normal creatinine clearance and received a diet of 110 mEq/day of sodium. Supine plasma renin activity was directly correlated with cardiac index (P less than.01) and cardiopulmonary blood volume (P=.01).P...<br/><br/>G M London, M E Safar, Y A Weiss, P L Corvol, J E Menard, A C Simon, P L Milliez (1977) <i>Arch Intern Med</i> <i></i> <i></i> 137: 8 1042-1047<br/>

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A study of 100 men with arterial hypertension showed that: 1) hypertension was predominantly moderate with 14% index of placebo reactivity; 2) only 3 patients had a surgically curable etiologic factor; 3) frequent associated findings were hereditary factors (60%), overweight and metabolic disorders (30 to 40%). Such results suggest that: a) hypertension could be treated, in the majority of patient...<br/><br/>Y A Weiss, M E Safar, N Aboras, A C Simon, P Milliez (1977) <i>Nouv Presse Med</i> <i></i> <i></i> 6: 21 1833-1836<br/>

http://publicationslist.org/alain.simon/refid268 2008-02-23T17:58:42Z

Blood pressure, renal blood flow, total blood volume (TBV), plasma renin activity, and vascular reactivities to angiotensin and norepinephrine were studied in 48 normotensive subjects and 106 essential, sustained, hypertensive patients with normal renal function, balanced sodium intake, and urinary output. A significant negative pressure-volume relationship was observed in normal subjects. Among t...<br/><br/>G M London, M E Safar, Y A Weiss, P L Corvol, J P Lehner, J M Menard, A C Simon, P L Milliez (1977) <i>Kidney Int</i> <i></i> <i></i> 11: 3 204-208<br/>

http://publicationslist.org/alain.simon/refid270 2008-02-23T17:58:42Z

Central hemodynamics were determined in 202 men including 101 normotensive and 101 permanent essential hypertensive patients of the same age. Cardiac output was identical in the two groups while blood pressure and total peripheral resistance were significantly different. Strong differences between the two groups are revealed by a systematic correlation study: (i) correlations of blood pressure (wi...<br/><br/>N P Chau, M E Safar, Y A Weiss, G M London, A C Simon, J P Lehner, P L Milliez (1977) <i>Contrib Nephrol</i> <i></i> <i></i> 8: 109-106<br/>

http://publicationslist.org/alain.simon/refid269 2008-02-23T17:58:42Z

Y A Weiss, M E Safar, N Aboras, A C Simon, P L Milliez (1977) <i>Acquis Med Recent</i> <i></i> <i></i> : 201-206<br/>

http://publicationslist.org/alain.simon/refid264 2008-02-23T17:58:42Z

Role of the clinical and experimental data suggesting the role of the sympathetic nervous system in some essential hypertension are reviewed: increase in heart rate and diastolic blood pressure during orthostatism, increase in cardiac output resulting from increase in cardiopulmonary blood volume and/or in myocardial contractility, increase in peripheral resistances, elevated plasma catecholamines...<br/><br/>M Andrejak, A Simon, J M Hardin, A Fournier, M Safar, J Quichaud (1977) <i>Nouv Presse Med</i> <i></i> <i></i> 6: 42 3963-3967<br/>

http://publicationslist.org/alain.simon/refid275 2008-02-23T17:58:42Z

In borderline and permanent hypertensives after rapid i.v. injection of dl-propranolol 0.2 mg/kg plasma levels were measured and were fitted to a two-compartment open-model. In borderline patients, characterized by a high basal cardiac output (CO), plasma levels were always lower than in permanent hypertensives. The biological half-life was reduced and the central volume of distribution, volume of...<br/><br/>Y A Weiss, M E Safar, C Chevillard, A Frydman, A Simon, P Lemaire, J M Alexandre (1976) <i>Eur J Clin Pharmacol</i> <i></i> <i></i> 10: 6 387-393<br/>

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Cardiac output, cardiopulmonary (CPBV) and total (TBV) blood volumes, vascular reactivity to norepinephrine and dopamine B hydroxylase (DBH) were determined in 41 borderline hypertensives patients in comparison with 28 normal subjects. Cardiac output (P less than 0.001) and CPBV/TBV ratio (P less than 0.01) were significantly increased. The ratio was directly correlated to the pressor-response to ...<br/><br/>A Simon, J P Lehner, M Safar, J M Alexandre, Y Weiss, P Milliez (1976) <i>Arch Mal Coeur Vaiss</i> <i></i> <i></i> 69: 12 1305-1309<br/>

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M Safar, Y Weiss, A Simon, P Milliez (1976) <i>Sem Hop Ther</i> <i></i> <i></i> 52: 7-8 355-359<br/>

http://publicationslist.org/alain.simon/refid273 2008-02-23T17:58:42Z

The pressor-response to norepinephrine was determined in the whole body circulation of 15 normal subjects and 86 untreated essential hypertensive patients. The slope, the threshold-dose and the critical-dose were calculated from the log dose-response curve. In the overall population (101 subjects) a slight correlation (r = +0.20 less than 0.05) was observed between the basal diastolic arterial pre...<br/><br/>G M London, M E Safar, Y A Weiss, A Simon, J P Lehner, P L Milliez (1976) <i>Biomedicine</i> <i></i> <i></i> 24: 3 178-182<br/>

http://publicationslist.org/alain.simon/refid274 2008-02-23T17:58:42Z

1. Blood pressure, blood volume and renal blood flow were determined in 101 men; forty-three were normal subjects and fifty-eight were untreated permanent essential hypertensive patients with normal renal function and equilibrated sodium balance. 2. A significant negative pressure-volume relationship was observed overall. The relationship could be expressed as a hyperbola whose slope expressed the...<br/><br/>M E Safar, N P Chau, Y A Weiss, G M London, A C Simon, P P Milliez (1976) <i>Clin Sci Mol Med</i> <i></i> <i></i> 50: 3 207-212<br/>

http://publicationslist.org/alain.simon/refid276 2008-02-23T17:58:42Z

The anti-hypertensive effect of propranolol is studied in 35 essential permanent hypertensive patients. The decrease in blood pressure in higher in the presence (p is less than 0.01) than in the absence of diuretic therapy. The anti-hypertensive effect is higher in severe than in moderate hypertension. No side effect was observed except the decrease in heart rate (p is less than 0.001). Dihydralaz...<br/><br/>M Safar, Y Weiss, A Simon, J P Lehner, P Milliez (1975) <i>Ann Med Interne (Paris)</i> <i></i> <i></i> 126: 11 737-743<br/>

http://publicationslist.org/alain.simon/refid277 2008-02-23T17:58:42Z

Antihypertensive therapy was performed in 47 patients having severe or malignant hypertension. The duration of the survey was two years. A highly significant decrease in blood pressure was observed. The decrease was not dependent on the type of antihypertensive treatment. Renal function was reduced at the beginning of the treatment. The renal insufficiency partly or totally diminished in course of...<br/><br/>M Safar, A Simon, B Maiz, Y Weiss, P Milliez (1975) <i>Nouv Presse Med</i> <i></i> <i></i> 4: 19 1403-1406<br/>

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M Safar, G London, Y Weiss, A Simon, P Milliez (1974) <i>Biomedicine</i> <i></i> <i></i> 21: 12 491-494<br/>