http://publicationslist.org/data/andrea.mele/atom.xml Andrea Melehttp://publicationslist.org/andrea.mele$basepathfavicon.icoRecent additions to Andrea Mele's PublicationsList.org pagehttp://publicationslist.org/publications.png2011-01-14T14:57:47Z http://publicationslist.org/andrea.mele/refid4 2011-01-14T14:50:45Z

Several studies have demonstrated that exposure to both acute and chronic aversive stimuli can affect neural activity in different brain areas. In particular it has been shown that stressful events can induce not only short-term changes in neural transmission and gene regulation, but also long-term changes that can lead to structural modification. In this study we investigated, in CD1 mice, the ef...<br/><br/>Arianna Rinaldi, Sara Vincenti, Francesca De Vito, Irene Bozzoni, Alberto Oliverio, Carlo Presutti, Paola Fragapane, Andrea Mele (2010) <i>Behav Brain Res</i> <i></i> <i></i> 208: 1 265-269<br/>

http://publicationslist.org/andrea.mele/refid3 2011-01-14T14:50:45Z

In this study the immediate-early gene Fos was used to investigate the response to different novel stimuli in a wide array of brain regions including the hippocampus, the rhinal cortex, the frontal cortex and different components of the striatal complex. Independent groups of CD-1 mice were exposed to three different novelty conditions: (1) novel environment (empty open field); (2) complex novel e...<br/><br/>A Rinaldi, S Romeo, C Agustín-Pavón, A Oliverio, A Mele (2010) <i>Neurobiol Learn Mem</i> <i></i> <i></i> 94: 3 373-381<br/>

http://publicationslist.org/andrea.mele/refid2 2011-01-14T14:47:03Z

Spatial memory formation is a dynamic process requiring a series of cellular and molecular steps, such as gene expression and protein translation, leading to morphological changes that have been envisaged as the structural bases for the engram. Despite the role suggested for medial temporal lobe plasticity in spatial memory, recent behavioral observations implicate specific components of the stria...<br/><br/>Valentina Ferretti, Pascal Roullet, Francesca Sargolini, Arianna Rinaldi, Valentina Perri, Martina Del Fabbro, Vivian J A Costantini, Valentina Annese, Gianluigi Scesa, Maria Egle De Stefano, Alberto Oliverio, Andrea Mele (2010) <i>Proc Natl Acad Sci U S A</i> <i></i> <i></i> 107: 17 7945-7950<br/>

http://publicationslist.org/andrea.mele/refid1 2011-01-14T14:47:03Z

Transcription factors with gradients of expression in neocortical progenitors give rise to distinct motor and sensory cortical areas by controlling the area-specific differentiation of distinct neuronal subtypes. However, the molecular mechanisms underlying this area-restricted control are still unclear. Here, we show that COUP-TFI controls the timing of birth and specification of corticospinal mo...<br/><br/>Giulio Srubek Tomassy, Elvira De Leonibus, Denis Jabaudon, Simona Lodato, Christian Alfano, Andrea Mele, Jeffrey D Macklis, Michèle Studer (2010) <i>Proc Natl Acad Sci U S A</i> <i></i> <i></i> 107: 8 3576-3581<br/>

http://publicationslist.org/andrea.mele/refid28 2011-01-14T14:53:19Z

Visuo-spatial deficits are the most consistently reported cognitive abnormalities in Parkinson's disease (PD), and they are frequently associated to motor symptoms in the early stages of the disease when dopamine loss is moderate and still restricted to the caudate-putamen. The metabotropic glutamate receptor 5 (mGluR5) antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP), has beneficial effects...<br/><br/>Elvira De Leonibus, Francesca Managò, Francesco Giordani, Francesco Petrosino, Sebastien Lopez, Alberto Oliverio, Marianne Amalric, Andrea Mele (2009) <i>Neuropsychopharmacology</i> <i></i> <i></i> 34: 3 729-738<br/>

http://publicationslist.org/andrea.mele/refid5 2011-01-14T14:50:45Z

Recent evidence demonstrated that dopamine within the nucleus accumbens mediates consolidation of both associative and nonassociative memories. However, the specific contribution of the nucleus accumbens subregions, core and shell, and of D1 and D2 receptors subtypes has not been yet clarified. The aim of this study was, therefore, to directly compare the effect of D1 and D2 dopamine receptor bloc...<br/><br/>Francesca Managò, Claudio Castellano, Alberto Oliverio, Andrea Mele, Elvira De Leonibus (2009) <i>Learn Mem</i> <i></i> <i></i> 16: 1 46-52<br/>

http://publicationslist.org/andrea.mele/refid9 2011-01-14T14:50:45Z

Glutamatergic transmission within the nucleus accumbens (Nac) is considered to subserve the transfer of different types of information from the cortical and limbic regions. In particular, it has been suggested that glutamatergic afferences from the hippocampus and the prefrontal cortex provide the main source of contextual information to the Nac. Accordingly, several authors have demonstrated that...<br/><br/>Valentina Ferretti, Francesca Sargolini, Alberto Oliverio, Andrea Mele, Pascal Roullet (2007) <i>Behav Brain Res</i> <i></i> <i></i> 179: 1 43-49<br/>

http://publicationslist.org/andrea.mele/refid6 2011-01-14T14:50:45Z

Accumulating evidence in humans demonstrated that visuo-spatial deficits are the most consistently reported cognitive abnormalities in Parkinson disease (PD). These deficits have been generally attributed to cortical dopamine degeneration. However, more recent evidence suggests that dopamine loss in the striatum is responsible for the visuo-spatial abnormalities in PD. Studies based on animal mode...<br/><br/>Elvira De Leonibus, Tiziana Pascucci, Sebastien Lopez, Alberto Oliverio, Marianne Amalric, Andrea Mele (2007) <i>Psychopharmacology (Berl)</i> <i></i> <i></i> 194: 4 517-525<br/>

http://publicationslist.org/andrea.mele/refid8 2011-01-14T14:50:45Z

Profilins are actin binding proteins essential for regulating cytoskeletal dynamics, however, their function in the mammalian nervous system is unknown. Here, we provide evidence that in mouse brain profilin1 and profilin2 have distinct roles in regulating synaptic actin polymerization with profilin2 preferring a WAVE-complex-mediated pathway. Mice lacking profilin2 show a block in synaptic actin ...<br/><br/>Pietro Pilo Boyl, Alessia Di Nardo, Christophe Mulle, Marco Sassoè-Pognetto, Patrizia Panzanelli, Andrea Mele, Matthias Kneussel, Vivian Costantini, Emerald Perlas, Marzia Massimi, Hugo Vara, Maurizio Giustetto, Walter Witke (2007) <i>EMBO J</i> <i></i> <i></i> 26: 12 2991-3002<br/>

http://publicationslist.org/andrea.mele/refid7 2011-01-14T14:50:45Z

Drugs activating group III metabotropic glutamate receptors (mGluRs) represent therapeutic alternatives to L-DOPA (L-3,4-dihydroxyphenylalanine) for the treatment of Parkinson's disease (PD). Their presynaptic location at GABAergic and glutamatergic synapses within basal ganglia nuclei provide a critical target to reduce abnormal activities associated with PD. The effects of selective group III mG...<br/><br/>Sebastien Lopez, Nathalie Turle-Lorenzo, Francine Acher, Elvira De Leonibus, Andrea Mele, Marianne Amalric (2007) <i>J Neurosci</i> <i></i> <i></i> 27: 25 6701-6711<br/>

http://publicationslist.org/andrea.mele/refid10 2011-01-14T14:50:45Z

Behaviourally relevant novel stimuli are known to activate the mesocorticolimbic dopaminergic (DAergic) system. In this study we tested the reactivity of this system in response to distinct kinds of novelty processing. Using the in vivo microdialysis technique, we measured extracellular amounts of dopamine (DA) in different DAergic terminal regions during a social learning task in rats. In the fir...<br/><br/>Elvira De Leonibus, Michel M M Verheij, Andrea Mele, Alexander Cools (2006) <i>Eur J Neurosci</i> <i></i> <i></i> 23: 5 1332-1340<br/>

http://publicationslist.org/andrea.mele/refid12 2011-01-14T14:50:45Z

The nucleus accumbens receives glutamatergic and dopaminergic inputs converging onto common dendrites. Recent behavioral data demonstrated that intra-accumbens administrations of either glutamate or dopamine (DA) antagonist impair spatial memory consolidation. Thus, also based on the biochemical and molecular findings demonstrating interactions among the different receptors subtypes for glutamate ...<br/><br/>Valentina Ferretti, Cédrick Florian, Vivian J A Costantini, Pascal Roullet, Arianna Rinaldi, Elvira De Leonibus, Alberto Oliverio, Andrea Mele (2005) <i>Psychopharmacology (Berl)</i> <i></i> <i></i> 179: 1 108-116<br/>

http://publicationslist.org/andrea.mele/refid11 2011-01-14T14:50:45Z

There is now accumulating evidence that the striatal complex in its two major components, the dorsal striatum and the nucleus accumbens, contributes to spatial memory. However, the possibility that different striatal subregions might modulate specific aspects of spatial navigation has not been completely elucidated. Therefore, in this study, two different learning procedures were used to determine...<br/><br/>Elvira De Leonibus, Alberto Oliverio, Andrea Mele (2005) <i>Learn Mem</i> <i></i> <i></i> 12: 5 491-503<br/>

http://publicationslist.org/andrea.mele/refid14 2011-01-14T14:50:45Z

We used the cDNA microarray technique to monitor simultaneously possible changes induced by hypergravity in the expression level of thousands of hippocampal genes. We tested the mRNA level of about 5000 genes in the hippocampus of mice subjected to 1.09 g (1g) or to 1.85 g (2g) for five repeated 1-h daily rotations in a centrifuge (g = 9.81 m/s2). Data were compared with those obtained for mice ke...<br/><br/>A Del Signore, S Mandillo, A Rizzo, E Di Mauro, A Mele, R Negri, A Oliverio, P Paggi (2004) <i>Eur J Neurosci</i> <i></i> <i></i> 19: 3 667-677<br/>

http://publicationslist.org/andrea.mele/refid13 2011-01-14T14:50:45Z

Nucleus accumbens dopamine is known to play an important role in motor activity and in behaviours governed by drugs and natural reinforcers, as well as in non-associative forms of learning. At the same time, activation of D1 and D2 dopamine receptors has been suggested to promote intracellular events related to neural plasticity. Therefore, in this study we wished to investigate the role of the tw...<br/><br/>A Mele, M Avena, P Roullet, E De Leonibus, S Mandillo, F Sargolini, R Coccurello, A Oliverio (2004) <i>Behav Pharmacol</i> <i></i> <i></i> 15: 5-6 423-431<br/>

http://publicationslist.org/andrea.mele/refid20 2011-01-14T14:50:45Z

Studies in humans have revealed that exposure to altered gravity may lead to impairments in cognitive functions. The objective of this study was to test whether mice exposed to hypergravity using a centrifuge apparatus showed learning impairments in a spatial learning task. Mice rotating at 1G or at 2G acceleration gravity and non-rotating controls were tested for reactivity to a spatial change af...<br/><br/>Silvia Mandillo, Arianna Del Signore, Paola Paggi, Nadia Francia, Daniela Santucci, Andrea Mele, Alberto Oliverio (2003) <i>Neurosci Lett</i> <i></i> <i></i> 336: 3 147-150<br/>

http://publicationslist.org/andrea.mele/refid19 2011-01-14T14:50:45Z

Generally recognition memory is distinguished into spatial and object memories that have been suggested to relay at a cortical level on different neural substrates. Recent studies point to a possible involvement of the nucleus accumbens (Nac) in spatial memory, demonstrating that blockade of glutamate antagonists within this structure impairs acquisition and consolidation of spatial information, w...<br/><br/>Francesca Sargolini, Pascal Roullet, Alberto Oliverio, Andrea Mele (2003) <i>Behav Brain Res</i> <i></i> <i></i> 138: 2 153-163<br/>

http://publicationslist.org/andrea.mele/refid18 2011-01-14T14:50:45Z

Recent evidence now points to a role of glutamate transmission within the nucleus accumbens (Nacc) in spatial learning and memory. Unfortunately, the role of the distinct classes of glutamate receptors within this structure in mediating the different steps of the memorization process is not clear. The aim of this study therefore was to further investigate this issue, trying to assess the involveme...<br/><br/>Francesca Sargolini, Cédrick Florian, Alberto Oliverio, Andrea Mele, Pascal Roullet (2003) <i>Learn Mem</i> <i></i> <i></i> 10: 4 285-292<br/>

http://publicationslist.org/andrea.mele/refid15 2011-01-14T14:50:45Z

Research on the role of the nucleus accumbens in behaviour has been largely focused on the functions of this structure in conditioning to appetitive stimuli. It has been suggested that a network comprising the nucleus accumbens and its convergent inputs might mediate dissociable functions in the acquisition, the consolidation and the retrieval of information. However, findings related to a role of...<br/><br/>Elvira De Leonibus, Vivian J A Costantini, Claudio Castellano, Valentina Ferretti, Alberto Oliverio, Andrea Mele (2003) <i>Eur J Neurosci</i> <i></i> <i></i> 18: 8 2365-2373<br/>

http://publicationslist.org/andrea.mele/refid16 2011-01-14T14:50:45Z

Cognitive deficits are a key feature of schizophrenia. N-Methyl-D-aspartate (NMDA) receptor antagonists and amphetamine are known to induce psychotic behaviors and cognitive deficits in animals and humans, often affecting visuo-spatial abilities. Phencyclidine (PCP), MK-801 and amphetamine (AMPH) have been used in pharmacological animal models of schizophrenia, but none of these models has focused...<br/><br/>S Mandillo, A Rinaldi, A Oliverio, A Mele (2003) <i>Behav Pharmacol</i> <i></i> <i></i> 14: 7 533-544<br/>

http://publicationslist.org/andrea.mele/refid17 2011-01-14T14:50:45Z

This study investigated the role of dorsal striatum in spatial memory in mice. The mice were tested for their ability to detect a spatial displacement 24 hr after training. In order to manipulate the dorsal striatum, focal administrations of the N-methyl-D-aspartate (NMDA) antagonist D-2-amino-5 phosphonopentanoic acid (AP-5) were performed immediately after training. AP-5 impaired the mice's abil...<br/><br/>Elvira De Leonibus, Pauline Lafenetre, Alberto Oliverio, Andrea Mele (2003) <i>Behav Neurosci</i> <i></i> <i></i> 117: 4 685-694<br/>

http://publicationslist.org/andrea.mele/refid22 2011-01-14T14:50:45Z

mdx mice are considered as a genetic homologous of human Duchenne muscular dystrophy. Recent evidence demonstrates that in mouse sympathetic ganglion dystrophin is involved in the stabilization of nicotinic acetylcholine receptor clusters. The purpose of this study was to verify possible effects of dystrophin alterations at the central level. This was assessed by evaluating the response to nicotin...<br/><br/>Roberto Coccurello, Claudio Castellano, Paola Paggi, Andrea Mele, Alberto Oliverio (2002) <i>Neuroreport</i> <i></i> <i></i> 13: 9 1219-1222<br/>

http://publicationslist.org/andrea.mele/refid21 2011-01-14T14:50:45Z

Pharmacological manipulation of both dopamine and glutamate systems affects motor responses in laboratory animals. The two systems, however, seem to act in opposite ways, since direct or indirect activation of dopamine receptors induces similar stimulatory effects to those seen following blockade of N-methyl-D-aspartate receptors. In the present study we compared the pattern of c-fos activation in...<br/><br/>E De Leonibus, A Mele, A Oliverio, A Pert (2002) <i>Neuroscience</i> <i></i> <i></i> 115: 1 67-78<br/>

http://publicationslist.org/andrea.mele/refid24 2011-01-14T14:50:45Z

Most of the research on ventral striatal functions has been focused on their role in modulating reward and motivation. More recently, a possible role of this structure in cognitive functions has been suggested. However, very little information is available on the involvement of the nucleus accumbens in the different stages of the consolidation process. In this study, the effect of focal injections...<br/><br/>P Roullet, F Sargolini, A Oliverio, A Mele (2001) <i>J Neurosci</i> <i></i> <i></i> 21: 6 2143-2149<br/>

http://publicationslist.org/andrea.mele/refid23 2011-01-14T14:50:45Z

We have recently shown that focal administration of dizocilpine hydrogen maleate (MK-801, a non-competitive N-methyl-D-aspartate antagonist) within the nucleus accumbens increases locomotor activity in a dopamine-independent manner. The purpose of this study was to investigate the neural network underlying locomotor stimulation induced by N-methyl-D-aspartate receptor blockade in the accumbens. In...<br/><br/>E De Leonibus, A Mele, A Oliverio, A Pert (2001) <i>Neuroscience</i> <i></i> <i></i> 104: 1 105-116<br/>

http://publicationslist.org/andrea.mele/refid25 2011-01-14T14:50:45Z

Some evidence suggests an involvement of nucleus accumbens in spatial learning. However, it is controversial whether the mesoaccumbens dopaminergic pathways play a specific role in the acquisition of spatial information.<br/><br/>R Coccurello, W Adriani, A Oliverio, A Mele (2000) <i>Psychopharmacology (Berl)</i> <i></i> <i></i> 152: 2 189-199<br/>

http://publicationslist.org/andrea.mele/refid26 2011-01-14T14:50:45Z

While experimental evidence shows that dopamine (DA) systems have an important role in locomotor function and in motivation, their role in the reactivity to spatial and non-spatial novelty is less well established.<br/><br/>W Adriani, F Sargolini, R Coccurello, A Oliverio, A Mele (2000) <i>Psychopharmacology (Berl)</i> <i></i> <i></i> 150: 1 67-76<br/>

http://publicationslist.org/andrea.mele/refid27 2011-01-14T14:50:45Z

The purpose of this study was to compare the effects of selective lesions of the three main sources of limbic afferents to the nucleus accumbens-fornix, prelimbic cortex and amygdala-with those induced by N-methyl-D-aspartate receptor blockage in this structure, in a non-associative task designed to estimate the ability of rodents to encode spatial and non-spatial relationships between discrete st...<br/><br/>F Sargolini, P Roullet, A Oliverio, A Mele (1999) <i>Neuroscience</i> <i></i> <i></i> 93: 3 855-867<br/>

http://publicationslist.org/andrea.mele/refid31 2011-01-14T14:56:54Z

Phencyclidine (PCP) and phencyclidine-like drugs (TCP, dexoxadrol, MK-801, and SKF 10,047) were evaluated for their ability to induce rotational behavior in rats with unilateral 6-OHDA lesions of the medial forebrain bundle and for their ability to alter striatal dopamine (DA) overflow with microdialysis procedures. All of the compounds tested produced rotational behavior ipsilateral to the lesion...<br/><br/>A Mele, K M Wozniak, F S Hall, A Pert (1998) <i>Psychopharmacology (Berl)</i> <i></i> <i></i> 135: 2 107-118<br/>

http://publicationslist.org/andrea.mele/refid30 2011-01-14T14:56:54Z

This study investigated the effects of stress on brain dopamine receptor densities in two inbred strains of mice. Analysis of [3H]SCH23390 binding by quantitative autoradiography revealed that repeated restraint stress significantly increases D1-like receptor density in the nucleus accumbens of mice of the DBA/2 strain whist reducing it in the caudate-putamen of C57BL/6 mice. No significant change...<br/><br/>S Cabib, L Giardino, L Calzá, M Zanni, A Mele, S Puglisi-Allegra (1998) <i>Neuroscience</i> <i></i> <i></i> 84: 1 193-200<br/>

http://publicationslist.org/andrea.mele/refid32 2011-01-14T14:56:54Z

This study evaluated and compared the role of mesoaccumbens dopamine and the ventral pallidal region in the locomotor stimulatory action of the non-competitive N-methyl-D-aspartate antagonist dizocilpine maleate and dopamine agonists. Intra-accumbens injections of both amphetamine (1, 5 and 25 nmol) and dizocilpine maleate (1, 5, 25 and 50 nmol) induced a dose-dependent increase in locomotor activ...<br/><br/>A Mele, D N Thomas, A Pert (1998) <i>Neuroscience</i> <i></i> <i></i> 82: 1 43-58<br/>

http://publicationslist.org/andrea.mele/refid29 2011-01-14T14:56:54Z

The aim of this study was to investigate the role played by intra-accumbens N-methyl-D-aspartate (NMDA) receptors in spatial information encoding. For this purpose, the effect of local administration of both competitive (AP-5) and non-competitive (MK-801) NMDA antagonists was assessed in a task designed to estimate the ability of rodents to encode spatial relationships between discrete stimuli. Th...<br/><br/>A Usiello, F Sargolini, P Roullet, M Ammassari-Teule, E Passino, A Oliverio, A Mele (1998) <i>Psychopharmacology (Berl)</i> <i></i> <i></i> 137: 2 175-183<br/>

http://publicationslist.org/andrea.mele/refid33 2011-01-14T14:56:54Z

The role of the nucleus accumbens (NA) in forming spatial representations was investigated in C57BL/6 (C57) and DBA/2 (DBA) inbred mice. One week before testing, bilateral excitotoxic lesions were performed in the NA using ibotenic acid. Testing consisted of placing mice in an arena containing 5 objects at a fixed location and, after habituation to the object configuration, examining their reactiv...<br/><br/>P Roullet, A Mele, M Ammassari-Teule (1997) <i>Behav Neurosci</i> <i></i> <i></i> 111: 5 976-984<br/>

http://publicationslist.org/andrea.mele/refid34 2011-01-14T14:56:54Z

Rats lesioned unilaterally in the medial forebrain bundle with 6-OHDA rotated ipsilateral to the lesion following injections of amphetamine, phencyclidine (PCP), and MK-801. Concurrent measurement of striatal dopamine (DA) in the intact striatum with in vivo microdialysis revealed a dissociation between rotational behavior and alterations in DA overflow induced by the three drugs. Amphetamine prod...<br/><br/>A Mele, D Fontana, A Pert (1997) <i>Synapse</i> <i></i> <i></i> 26: 3 218-224<br/>

http://publicationslist.org/andrea.mele/refid37 2011-01-14T14:56:54Z

Injections of glutamatergic NMDA as well as dopaminergic antagonists produce selective place- but not cue-learning deficits in associative spatial tasks. The present work was aimed at examining if the blockade of NMDA and dopaminergic receptors interferes with the encoding of spatial information in a non-associative task specifically designed for rodents. CD1 mice injected with MK-801 (0.1 and 0.2...<br/><br/>P Roullet, A Mele, M Ammassari-Teule (1996) <i>Psychopharmacology (Berl)</i> <i></i> <i></i> 126: 1 55-61<br/>

http://publicationslist.org/andrea.mele/refid36 2011-01-14T14:56:54Z

This study explores the functional interaction between glutamatergic and dopaminergic systems in the modulation of two behavioral responses: locomotor activity and memory consolidation assessed with one-trial inhibitory avoidance. In agreement with previous reports, the NMDA receptor antagonist, (+)-MK-801 ((+)-5-methyl-10,11-dihydro(a,d) cyclohepten-5,10-imine hydrogen maleate), dose dependently ...<br/><br/>A Mele, C Castellano, A Felici, S Cabib, S Caccia, A Oliverio (1996) <i>Eur J Pharmacol</i> <i></i> <i></i> 308: 1 1-12<br/>

http://publicationslist.org/andrea.mele/refid35 2011-01-14T14:56:54Z

The effect of the administration of the muscarinic cholinergic agonist oxotremorine on locomotor activity was investigated in DBA/2 mice subjected to chronic restraint stress of different durations (120 min daily for 10, 14 or 18 days). Oxotremorine induced a depressant effect on locomotion, which was reduced after 10 and 14 days of restraint, but not after a 18-day restraint stress. Acetylcholine...<br/><br/>D Pullia, F R D'Amato, A Mele, A Oliverio, A Zocchi, F Pavone (1996) <i>Brain Res</i> <i></i> <i></i> 743: 1-2 333-336<br/>

http://publicationslist.org/andrea.mele/refid40 2011-01-14T14:56:54Z

The effects of pretreatment with the non-competitive NMDA antagonist (+)MK-801 on the behavioral alterations induced by repeated restraint stress were investigated. Repeatedly stressed (restraint stress 2 h a day x 10 days) mice showed enhanced sensitivity to the inhibitory effects of a low dose of direct dopamine agonist, apomorphine (0.25 mg/kg), on climbing behavior. On the other hand, no chang...<br/><br/>A Mele, S Cabib, A Oliverio (1995) <i>Psychopharmacology (Berl)</i> <i></i> <i></i> 117: 3 313-317<br/>

http://publicationslist.org/andrea.mele/refid39 2011-01-14T14:56:54Z

Post-training administration of the N-methyl-D-aspartate (NMDA) receptors antagonist CPP, at doses of 0.5 and 1.0 mg/kg, impaired, in dose-dependent fashion, retention of the inhibitory avoidance response in C57BL/6J (C57) mice. Post-training subeffective doses of selective D1 and D2 dopamine receptor agonists, were able to antagonize the action of CPP, while subeffective doses of SCH 23390 and (-...<br/><br/>A Mele, C Castellano, V Cestari, A Oliverio (1995) <i>Neurobiol Learn Mem</i> <i></i> <i></i> 63: 2 143-148<br/>

http://publicationslist.org/andrea.mele/refid38 2011-01-14T14:56:54Z

Post-training administration of the N-methyl-D-aspartate (NMDA) antagonists CPP (0.5 and 1.0 mg/kg) and MK-801 (0.25 and 0.5 mg/kg) impaired, in a dose dependent fashion, the one-trial inhibitory avoidance response in NMRI mice. The D1 dopamine (DA) agonist SKF 38393 (10 and 20 mg/kg) and the D2 agonist quinpirole (0.5 and 1.0 mg/kg) instead facilitate the response in the same behavioral paradigm....<br/><br/>A Mele, C Castellano, A Oliverio (1995) <i>Psychopharmacology (Berl)</i> <i></i> <i></i> 121: 3 401-405<br/>

http://publicationslist.org/andrea.mele/refid41 2011-01-14T14:56:54Z

The non-competitive N-methyl-D-aspartate (NMDA) antagonist MK-801 (dizocilpine) was tested, alone or in combination with chlorpromazine, in mice previously trained in the shuttlebox. The lowest doses of dizocilpine (0.02 and 0.04 mg kg-1) attenuated the disrupting action of the neuroleptic (1.5 mg kg-1) on avoidance-performance, while avoidance depression induced by 1.5 and 2 mg kg-1 chlorpromazin...<br/><br/>A Mele, M Battaglia, M Sansone (1994) <i>J Pharm Pharmacol</i> <i></i> <i></i> 46: 5 390-392<br/>

http://publicationslist.org/andrea.mele/refid43 2011-01-14T14:56:54Z

The extracellular concentration of dopamine in the ventral striatum was measured daily by means of brain microdialysis. Chronic cocaine (10 mg/kg twice daily) altered the dopamine output compared to that in vehicle-injected rats, inducing a pronounced increase in the first 3 days followed by a clear-cut decrease. This reduction in the output of dopamine during chronic cocaine as well as during wit...<br/><br/>A Imperato, A Mele, M G Scrocco, S Puglisi-Allegra (1992) <i>Eur J Pharmacol</i> <i></i> <i></i> 212: 2-3 299-300<br/>

http://publicationslist.org/andrea.mele/refid42 2011-01-14T14:56:54Z

Many investigations using the microdialysis technique have been performed in anesthetized animals, both in this laboratory and elsewhere. Concern arises with this preparation that the anesthetic may compromise neuronal function, or that it may interact with test drugs affecting neurotransmitter overflow. In addition, in these studies the microdialysis probe typically is introduced into the brain o...<br/><br/>M E Hamilton, A Mele, A Pert (1992) <i>Brain Res</i> <i></i> <i></i> 597: 1 1-7<br/>

http://publicationslist.org/andrea.mele/refid44 2011-01-14T14:56:54Z

Rats were administered various IP doses of the high-affinity dopamine (DA) reuptake inhibitor 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-[3-phenylpropyl]piperazine (GBR12909). The caudate nuclei were removed 60 min after drug administration and stored at -70 degrees C. Striatal membranes were prepared later. The results demonstrated that GBR12909 produced a dose-dependent decrease in the binding of...<br/><br/>R B Rothman, A Mele, A A Reid, H C Akunne, N Greig, A Thurkauf, B R de Costa, K C Rice, A Pert (1991) <i>Pharmacol Biochem Behav</i> <i></i> <i></i> 40: 2 387-397<br/>

http://publicationslist.org/andrea.mele/refid45 2011-01-14T14:56:54Z

Dopaminergic systems are thought to play a major role in the stimulant and reinforcing properties of drugs of abuse, including ethanol. The present study describes the effects of local perfusion with ethanol (and other alcohols) on extracellular dopamine in the striatum and nucleus accumbens. Following the establishment of basal dopamine levels (2-3 h), various concentrations of ethanol in artific...<br/><br/>K M Wozniak, A Pert, A Mele, M Linnoila (1991) <i>Brain Res</i> <i></i> <i></i> 540: 1-2 31-40<br/>

http://publicationslist.org/andrea.mele/refid46 2011-01-14T14:56:54Z

R B Rothman, A Mele, A A Reid, H Akunne, N Grieg, A Thurkauf, B R deCosta, K C Rice, A Pert (1990) <i>NIDA Res Monogr</i> <i></i> <i></i> 105: 359-360<br/>

http://publicationslist.org/andrea.mele/refid47 2011-01-14T14:56:54Z

Regional neurotransmitter changes after acute and chronic electroconvulsive shock (ECS) were studied using the technique of repeated microdialysis. Microdialysis was carried out on alternate sides of the brains of anaesthetised rats before and during the first and the eighth ECS or sham (control) treatments. Extracellular fluid release of monoamines and their metabolites was measured in the fronta...<br/><br/>P Glue, M J Costello, A Pert, A Mele, D J Nutt (1990) <i>Psychopharmacology (Berl)</i> <i></i> <i></i> 100: 1 60-65<br/>

http://publicationslist.org/andrea.mele/refid48 2011-01-14T14:56:54Z

The experiments reported in this study tested the hypothesis that tight binding dopamine (DA) reuptake inhibitors might act as cocaine antagonists. Binding studies demonstrated that the high affinity dopamine reuptake inhibitor, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-[3-phenylpropyl]piperazine (GBR12909) produced a wash-resistant inhibition of the DA transporter in rat striatal membranes as lab...<br/><br/>R B Rothman, A Mele, A A Reid, H Akunne, N Greig, A Thurkauf, K C Rice, A Pert (1989) <i>FEBS Lett</i> <i></i> <i></i> 257: 2 341-344<br/>

http://publicationslist.org/andrea.mele/refid49 2011-01-14T14:56:54Z

After two hours of immobilization stress, C57BL/6 mice presented a significant reduction of spontaneous locomotion and a slight reduction of spontaneous climbing. The effect of stress on locomotor activity disappeared after ten daily sessions of immobilization while this chronic treatment increased the effect of stress on spontaneous climbing. Twenty-four hr after the last stressful experience the...<br/><br/>S Cabib, E Kempf, C Schleef, A Mele, S Puglisi-Allegra (1988) <i>Physiol Behav</i> <i></i> <i></i> 43: 2 223-227<br/>

http://publicationslist.org/andrea.mele/refid50 2011-01-14T14:56:54Z

Corticotropin releasing factor (CRF) and sauvagine (SVG) when injected ICV both reduced aggressive behavior and sociability while increasing defensive behavior in isolated DBA/2 mice interacting with a group-housed intruder. SVG was more effective than CRF in producing such behavioral effects. These results add further evidence to the similarity between CRF and SVG, and are discussed in terms of t...<br/><br/>A Mele, S Cabib, A Oliverio, P Melchiorri, S Puglisi-Allegra (1987) <i>Peptides</i> <i></i> <i></i> 8: 5 935-938<br/>

http://publicationslist.org/andrea.mele/refid51 2011-01-14T14:56:54Z

S Puglisi-Allegra, A Mele, S Cabib (1984) <i>Prog Clin Biol Res</i> <i></i> <i></i> 167: 209-225<br/>