Anna Czarnecka's Publications List

Mitochondrial NADH-dehydrogenase subunit 3 (ND3) polymorphism (A10398G) and sporadic breast cancer in Poland.

2010-08-05T13:58:48Z

Mitochondria are subcellular organelles that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). As suggested over 70 years ago by Otto Warburg and recently confirmed with molecular techniques, alterations in respiratory activity and mitochondrial DNA (mtDNA) appear to be common features of malignant cells. Somatic mtDNA mutations have been reported in many types of ca...

Anna M Czarnecka, Tomasz Krawczyk, Marek Zdrozny, Jan Lubiński, Rebecca S Arnold, Wojciech Kukwa, Anna Scińska, Paweł Golik, Ewa Bartnik, John A Petros (2010) Breast Cancer Res Treat 121: 2 511-518

Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor.

2010-08-05T13:58:48Z

Breast cancer is the most frequently diagnosed female cancer all over the world. Although the molecular genetics of this disease has been the focus of many projects for over 20 years, the number of prognostic markers used in clinics is still unsatisfactory. Mitochondrial DNA mutations have been reported in many breast cancer studies. To investigate the possible role of mitochondrial inherited poly...

Anna M Czarnecka, Aleksandra Klemba, Tomasz Krawczyk, Marek Zdrozny, Rebecca S Arnold, Ewa Bartnik, John A Petros (2010) Oncol Rep 23: 2 531-535

Molecular oncology focus - Is carcinogenesis a 'mitochondriopathy'?

2010-08-05T13:58:48Z

Mitochondria are sub-cellular organelles that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). As suggested over 70 years ago by Otto Warburg and recently confirmed with molecular techniques, alterations in respiratory activity and in mitochondrial DNA (mtDNA) appear to be common features of malignant cells. Somatic mtDNA mutations have been reported in many types o...

Anna M Czarnecka, Jerzy S Czarnecki, Wojciech Kukwa, Francesco Cappello, Anna Scińska, Andrzej Kukwa (2010) J Biomed Sci 17:

Mitochondrial DNA mutations in cancer--from bench to bedside.

2010-08-05T13:58:48Z

Mitochondria are cell organelles mostly known for their production of ATP through oxidative phosphorylation. As suggested over 70 years ago by O. Warburg and recently confirmed with molecular techniques, alterations in respiratory activity and mitochondrial DNA appear to be a common feature of malignant cells. Somatic mtDNA mutations have been reported in many types of cancer cells. MtDNA mutation...

Anna Malgorzata Czarnecka, Wojciech Kukwa, Tomasz Krawczyk, Anna Scinska, Andrzej Kukwa, Francesco Cappello (2010) Front Biosci 15: 437-460

Mitochondrial DNA Mutations in Tumors

2009-02-22T13:16:10Z

Mitochondria are subcellular organelles with the most well-known and best-characterized function of adenosine triphosphate (ATP) production through oxidative phosphorylation (OXPHOS). Mitochondria play an important role in apoptosis, a fundamental biological process by which cells die in a programmed manner and are the strategic point in the cell death cascade. Alterations in respiratory activity ...

Anna Czarnecka, Ewa Bartnik (2009) Cellular Respiration and Carcinogenesis 1-12

Breast cancer as a mitochondrial disorder

2009-03-17T20:27:33Z

Mitochondria have been implicated in cell transformation since Otto Warburg considered ‘respiration damage’ to be a pivotal feature of cancer cells. Numerous somatic mitochondrial DNA (mtDNA) mutations have been found in various types of neoplasms, including breast cancer. Establishing the mtDNA mutation pattern in breast cancer cells may enhance the specificity of cancer diagnostics, detectio...

Katarzyna Plak, Anna M. Czarnecka, Tomasz Krawczyk, Pawel Golik, Ewa Bartnik (2009) Oncology Reports 21: 4 845-851

Common mitochondrial polymorphisms as risk factor for endometrial cancer.

2010-08-05T13:58:48Z

Endometrial carcinoma is the most commonly diagnosed gynaecological cancer in developed countries. Although the molecular genetics of this disease has been in the focus of many research laboratories for the last 20 years, relevant prognostic and diagnostic markers are still missing. At the same time mitochondrial DNA mutations have been reported in many types of cancer during the last two decades....

Anna M Czarnecka, Aleksandra Klemba, Andrzej Semczuk, Katarzyna Plak, Barbara Marzec, Tomasz Krawczyk, Barbara Kofler, Pawel Golik, Ewa Bartnik (2009) Int Arch Med 2: 1

Metabolic markers of the head and neck cancers--clinical applications and the biochemical background

2010-08-05T13:58:48Z

The problem of diagnosis in the field of head and neck region is still valid. Specific diagnosis and precise estimation of the tumor's size with the use of CT and MRI imaging is generally unsatisfactory. The Positron Emission Tomography (PET) supports this process with additional information about the tumor's metabolism. Numerous publications show that PET-CT has a great influence on the evaluatio...

Anna M Czarnecka, Wojciech Kukwa, Anna Scińska, Andrzej Kukwa (2009) Otolaryngol Pol 63: 6 478-484

Breast cancer as a mitochondrial disorder (Review).

2010-08-05T13:58:48Z

Mitochondria have been implicated in cell transformation since Otto Warburg considered 'respiration damage' to be a pivotal feature of cancer cells. Numerous somatic mitochondrial DNA (mtDNA) mutations have been found in various types of neoplasms, including breast cancer. Establishing the mtDNA mutation pattern in breast cancer cells may enhance the specificity of cancer diagnostics, detection an...

Katarzyna Plak, Anna M Czarnecka, Tomasz Krawczyk, Pawel Golik, Ewa Bartnik (2009) Oncol Rep 21: 4 845-851

Molecular biology of endometrial carcinoma

2010-08-05T13:58:48Z

Endometrial carcinoma is among the most frequently diagnosed gynecological malignancies in highly developed countries. Research has been conducted for 20 years to define the molecular pathology of this disease and much is already known, but adequate prognostic, diagnostic, and monitoring markers are still missing. Recently, mitochondrial research opened a new perspective. The participation of abno...

Aleksandra Klemba, Wojciech Kukwa, Ewa Bartnik, Tomasz Krawczyk, Anna Scińska, Paweł Golik, Anna M Czarnecka (2008) Postepy Hig Med Dosw (Online) 62: 420-432

CD1a down-regulation in primary invasive ductal breast carcinoma may predict regional lymph node invasion and patient outcome.

2008-12-10T13:33:17Z

AIMS: CD1a is a molecule belonging to the highly conserved group of CD1 proteins. Its expression in dendritic cells is related to the presentation of tumour-derived glycolipid antigens to T cells and, consequently, the development of a successful antitumour response. The aim was to investigate the presence of CD1a+ cells in both primary tumours and lymph nodes (LN) of a series of 35 invasive ducta...

G La Rocca, R Anzalone, S Corrao, F Magno, F Rappa, S Marasà, A M Czarnecka, L Marasà, C Sergi, G Zummo, F Cappello (2008) Histopathology 52: 2 203-212

Mitochondrial DNA mutations in the pathogenesis in the head and neck squamous cell carcinoma

2008-12-10T15:52:18Z

Data reported until today suggested a pivotal role of nuclear DNA mutations in the process of carcinogenesis. Recently more and more authors claim that disruption of mitochondrial DNA should not be excluded from this analysis. mtDNA have been reported in many cancers of head and neck region. Mitochondrial D-loop has been proven to be mutation hot - spot with majority of mutations in the positions ...

Grzegorz Pietka, Wojciech Kukwa, Ewa Bartnik, Anna Scińska, Anna M Czarnecka (2008) Otolaryngol Pol 62: 2 158-164

The impact of mtDNA mutations on proteins structure in selected types of cancer

2010-08-05T13:58:48Z

Recently published papers report a large number of mitochondrial DNA mutations in many different cancer types, but their significance for electron transport chain proteins remains unknown. This review covers structural mutations of mitochondrial genes, choosing prostate cancer, esophageal cancer and epithelioma as research models. As all mitochondrial genes encode subunits of the electron transpor...

Katarzyna Plak, Wojciech Kukwa, Ewa Bartnik, Paweł Golik, Anna Scińska, Tomasz Krawczyk, Anna M Czarnecka (2008) Postepy Biochem 54: 2 151-160

Multi-Chaperones-Interactors Network in Mitochondria (MtCIN): Its Role in Carcinogenesis and Methodology of Analysis

2008-12-10T13:35:40Z

In human mitochondria, the characterization of multiple functional and structural interactions of mitochondrial chaperones is needed for the understanding of the cellular protein biogenesis as well as of the process of carcinogenesis. In light of current available data, we propose that mitochondrial Hsp70, Hsp60/10, DnaJ-like proteins, GrpE-like proteins, Clp/Hsp100, and Hsp90 families should be ...

Anna M. Czarnecka, Jerzy S. Czarnecki, Anna Ribbene, and Francesco Cappello (2008) J. Cancer Mol. 4: 99-108

Methodology For Mitochondrial DNA Research In Oncology: Goals And Pitfalls

2008-12-10T15:49:34Z

ABSTRACT. Mitochondrial DNA has been described as veritable Pandora’s box of pathogenic mutations associated with a wide variety of clinical syndromes including cancer. Nevertheless careful reanalysis of methodological and methodical criteria used in experiments shows that numerous papers could not be used as relevant source of clinically applicative data. It has been shown that much noise has b...

Anna M. Czarnecka, T. Krawczyk, J. S. Czarnecki, W. Kukwa, Anna Ścińska, Anna Ribbene, Rosaria Lo Verde, Annalisa Sunseri, Giovanni Peri (2008) ARS Medica Tomitana XIV: 1 48-64

Występowanie mutacji w mtDNA i ich potencjalny wpływ na strukturę białek w wybranych typach nowotworów

2009-05-16T16:32:33Z

Badania ostatnich lat wskazują na występowanie w wielu typach nowotworów zwiększonej częstości mutacji w mitochondrialnym DNA, jednak ich znaczenie dla struktury i funkcji systemu fosforylacji oksydacyjnej nie zostało dotychczas podsumowane. W niniejszej pracy omówiono mutacje genów mitochondrialnych kodujących białka w raku prostaty, przełyku oraz w nabłoniaku rdzeniastym. Ze względ...

Katarzyna Plak, Wojciech Kukwa,, Ewa Bartnik, Paweł Golik, Anna Ścińska, Tomasz Krawczyk, Anna M. Czarnecka (2008) Postępy Biochemii 54: 2 151-160

Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells.

2010-08-05T13:58:48Z

Hsp60, a mitochondrial chaperonin highly conserved during evolution, has been found elevated in the cytosol of cancer cells, both in vivo and in vitro, but its role in determining apoptosis during oxidative stress (OS) has not yet been fully elucidated. The aim of the present work was to study the effects of OS on Hsp60 levels and its interactions with procaspase- 3 (p-C3) and p53 in tumor cells. ...

C Campanella, F Bucchieri, N M Ardizzone, A Marino Gammazza, A Montalbano, A Ribbene, V Di Felice, M Bellafiore, S David, F Rappa, M Marasà, G Peri, F Farina, A M Czarnecka, E Conway de Macario, A J L Macario, G Zummo, F Cappello (2008) Eur J Histochem 52: 4 221-228

Cancer as a “Mitochondriopathy”

2008-12-10T15:39:28Z

Mitochondria are subcellular organelles, whose well-known function is to produce ATP through the oxidative phosphorylation system. Alterations in respiratory activity and mitochondrial DNA (mtDNA) appear to be a general feature of malignant cells. The presence of mtDNA mutations has been reported in various cancer cells, and the abundance of mtDNA damage is consistent with the intrinsic suscepti...

Anna M Czarnecka, Antonella Marino Gammazza, Valentina Di Felice, Giovanni Zummo, and Francesco Cappello (2007) J. Cancer Mol. 3: 71-79

Hsp60 and Hspl0 as antitumor molecular agents.

2008-12-10T13:33:17Z

The molecular chaperones Hsp60 and Hsp10 are, according to recent reports, involved in cancer development and progression. We, for instance, have found that their expression varies with distinctive patterns in different malignancies: they are overexpressed in colorectal, exocervical and prostate carcinogenesis, and colorectal cancer progression, but they are downregulated during bronchial carcinog...

Francesco Cappello, Anna M Czarnecka, Giampiero La Rocca, Antonino Di Stefano, Giovanni Zummo, Alberto J L Macario (2007) Cancer Biol Ther 6: 4 487-489

Heat shock protein 10 and signal transduction: a "capsula eburnea" of carcinogenesis?

2007-09-10T13:27:41Z

To date, little is known either about the physical interactions of heat shock protein 10 (Hsp10) with other proteins within the cell or its involvement in signal transduction pathways. Hsp10 has been considered mainly as a partner of Hsp60 in the Hsp60/10 protein folding machine. Only recently, Hsp10 was reported to interact with proteins involved in deoxyribonucleic acid checkpoint inactivation, ...

Anna M Czarnecka, Claudia Campanella, Giovanni Zummo, Francesco Cappello (2006) Cell Stress Chaperones 11: 4 287-294

Mitochondrial chaperones in cancer: from molecular biology to clinical diagnostics.

2007-09-10T13:27:41Z

Mitochondria are cell organelles involved in processes of cell life and death, and therefore also in tumoral transformation. Indeed, mitochondria dysfunction is a prominent feature of cancer cells. Mitochondrial proteins and DNA have also been previously studied as markers of tumorigenesis. Heat shock proteins (HSPs) are ubiquitous evolutionary conserved proteins. HSPs enhance their expression in ...

Anna M Czarnecka, Claudia Campanella, Giovanni Zummo, Francesco Cappello (2006) Cancer Biol Ther 5: 7 714-720

Balance between transcription and RNA degradation is vital for Saccharomyces cerevisiae mitochondria: reduced transcription rescues the phenotype of deficient RNA degradation.

2007-09-10T13:27:41Z

The Saccharomyces cerevisiae SUV3 gene encodes the helicase component of the mitochondrial degradosome (mtEXO), the principal 3'-to-5' exoribonuclease of yeast mitochondria responsible for RNA turnover and surveillance. Inactivation of SUV3 (suv3Delta) causes multiple defects related to overaccumulation of aberrant transcripts and precursors, leading to a disruption of mitochondrial gene expressio...

Agata T Rogowska, Olga Puchta, Anna M Czarnecka, Aneta Kaniak, Piotr P Stepien, Pawel Golik (2006) Mol Biol Cell 17: 3 1184-1193

Mitochondria Jako Integratory Apoptozy

2008-12-10T16:01:29Z

Supernumerary, old or damaged cells of multicellular organisms are eliminated by apoptosis - programmed cell death. Apoptosis is accompanied by series of characteristic morphological and biochemical events. The cell activates a cascade of cysteine proteases, caspases, that digest target proteins. Nucleases are also activated, which together leads to irreversible cell damage within few hours. Mitoc...

AM Czarnecka, P Golik , E Bartnik (2006) Postepy Biologii Komorki 33: 3 525-542

Mitochondrial DNA mutations in human neoplasia.

2007-09-10T13:27:41Z

Many models of tumour formation have been put forth so far. In general they involve mutations in at least three elements within the cell: oncogenes, tumour suppressors and regulators of telomere replication. Recently numerous mutations in mitochondria have been found in many tumours, whereas they were absent in normal tissues from the same individual. The presence of mutations, of course, does not...

Anna M Czarnecka, Pawel Golik, Ewa Bartnik (2006) J Appl Genet 47: 1 67-78

The value of immunohistochemical research on PCNA, p53 and heat shock proteins in prostate cancer management: a review.

2007-09-10T13:27:41Z

This review addresses the significance of the expression of proliferating cell nuclear antigen (PCNA), p53 and some heat shock proteins (Hsps) in prostate carcinoma (PC). In fact, PCNA and p53 are two widely discussed tools in PC diagnosis, mainly because of the controversy regarding the significance of their expression during prostate cancer development and progression. At the same time, only few...

F Cappello, A Ribbene, C Campanella, A M Czarnecka, R Anzalone, F Bucchieri, A Palma, G Zummo (2006) Eur J Histochem 50: 1 25-34