http://publicationslist.org/data/anna.solini/atom.xml Anna Solinihttp://publicationslist.org/anna.solini$basepathfavicon.icoRecent additions to Anna Solini's PublicationsList.org pagehttp://publicationslist.org/publications.png2010-02-23T15:11:40Z http://publicationslist.org/anna.solini/refid5 2010-02-23T15:10:46Z

Some cytokines and proinflammatory mediators are considered markers of increased atherothrombotic risk. Few information is available on the effects of acute glucose and insulin variations on these markers of atherosclerosis. We assessed the acute effect of glucose and insulin on soluble CD40 ligand (sCD40L), IL-6, and P-selectin levels, evaluating their relationship with insulin sensitivity in nor...<br/><br/>E Muscelli, S Camastra, E Santini, A Casolaro, S Pinnola, B D Astiarraga, A Solini (2009) <i>Horm Metab Res</i> <i></i> <i></i> 41: 7 568-572<br/>

http://publicationslist.org/anna.solini/refid7 2010-02-23T15:10:46Z

INTRODUCTION: The modulation of the purinergic receptor P2X7 may be implicated in human carcinogenesis. The 1513A>C and 489C>T polymorphisms of P2X7R gene induce loss of function and gain of function, respectively. AIM: The aim of the study was to assess the frequency of both 1513A>C and 489C>T polymorphisms in patients with papillary thyroid carcinoma (PTC) and to evaluate the possible associatio...<br/><br/>Angela Dardano, Simonetta Falzoni, Nadia Caraccio, Antonio Polini, Sara Tognini, Anna Solini, Piero Berti, Francesco Di Virgilio, Fabio Monzani (2009) <i>J Clin Endocrinol Metab</i> <i></i> <i></i> 94: 2 695-698<br/>

http://publicationslist.org/anna.solini/refid4 2010-02-23T15:10:46Z

The predisposition to thrombogenesis is increased in essential hypertension, and hypertensive patients are prone to develop more vulnerable atherosclerotic plaques. To evaluate the possible influence of family history of hypertension on some indicators of early atherosclerosis, we studied eighty-five healthy normotensive individuals with (FH+) or without (FH-) family history of essential hypertens...<br/><br/>A Solini, E Santini, A Passaro, S Madec, E Ferrannini (2009) <i>J Hum Hypertens</i> <i></i> <i></i> 23: 12 801-807<br/>

http://publicationslist.org/anna.solini/refid6 2010-02-23T15:10:46Z

Extracellular nucleotides modulate several cell functions via specific receptors, P2X and P2Y. We explored the differential role of these receptors in the control of insulin secretion (InSec). In INS-1e cells grown in 11 mm glucose and then acutely exposed to 3.3, 7.5, 11, or 20 mm, coincubation with ATP, the global agonist of both P2X and P2Y receptors, induced a dose-dependent (P < 0.0001) reduc...<br/><br/>Eleonora Santini, Sabina Cuccato, Stephanie Madec, Daniele Chimenti, Ele Ferrannini, Anna Solini (2009) <i>Endocrinology</i> <i></i> <i></i> 150: 6 2596-2602<br/>

http://publicationslist.org/anna.solini/refid1 2010-02-23T15:10:46Z

BACKGROUND: Elevated levels of the proinflammatory cytokine soluble CD40 ligand (sCD40L) were reported in subjects with diabetes, impaired glucose tolerance, metabolic syndrome (MS), obesity, and insulin resistance. Metabolic abnormalities might also account for increased sCD40L in subjects with essential hypertension. METHODS: Several metabolic and vascular correlates of sCD40L levels have been i...<br/><br/>Giuseppe Penno, Laura Pucci, Giulia Dell'Omo, Daniela Lucchesi, Roberto Miccoli, Stefano Del Prato, Anna Solini, Roberto Pedrinelli (2009) <i>Am J Hypertens</i> <i></i> <i></i> 22: 9 1007-1013<br/>

http://publicationslist.org/anna.solini/refid2 2010-02-23T15:10:46Z

OBJECTIVE: Atherosclerosis is accelerated in subjects with type 2 diabetes by unknown mechanisms. We identified tissue inhibitor of metalloproteinase 3 (TIMP3), the endogenous inhibitor of A disintegrin and metalloprotease domain 17 (ADAM17) and other matrix metalloproteinases (MMPs), as a gene modifier for insulin resistance and vascular inflammation in mice. We tested its association with athero...<br/><br/>Marina Cardellini, Rossella Menghini, Eugenio Martelli, Viviana Casagrande, Arianna Marino, Stefano Rizza, Ottavia Porzio, Alessandro Mauriello, Anna Solini, Arnaldo Ippoliti, Renato Lauro, Franco Folli, Massimo Federici (2009) <i>Diabetes</i> <i></i> <i></i> 58: 10 2396-2401<br/>

http://publicationslist.org/anna.solini/refid3 2010-02-23T15:10:46Z

BACKGROUND: Retinol-binding protein-4 (RBP4) is a novel adipokine able to modulate the action of insulin in several tissues. A variable degree of insulin resistance characterizes the vast majority of hypertensive (HYP) patients. The aim of this study was to evaluate the relationship between RBP4 and essential hypertension, exploring potential links between RBP4 and other adipokines with some proxi...<br/><br/>Anna Solini, Eleonora Santini, Stephanie Madec, Chiara Rossi, Elza Muscelli (2009) <i>Am J Hypertens</i> <i></i> <i></i> 22: 9 1001-1006<br/>

http://publicationslist.org/anna.solini/refid12 2010-02-23T15:10:46Z

Nucleotides are increasingly recognized as nonredundant extracellular signals for chemotaxis, cell growth, and cytokine release. Effects of extracellular nucleotides are mediated by P2 receptors, among which the P2X(7) subtype is attracting increasing attention for its involvement in apoptosis, cell growth, and cytokine release. Recent studies showed that P2X(7) is overexpressed in chronic lymphoc...<br/><br/>Anna Solini, Sabina Cuccato, Davide Ferrari, Eleonora Santini, Sara Gulinelli, Maria Giulia Callegari, Angela Dardano, Pinuccia Faviana, Stephanie Madec, Francesco Di Virgilio, Fabio Monzani (2008) <i>Endocrinology</i> <i></i> <i></i> 149: 1 389-396<br/>

http://publicationslist.org/anna.solini/refid13 2010-02-23T15:10:46Z

BACKGROUND: Type 2 diabetes (T2D) is characterized by an accelerated atherogenesis, a process to which both proliferative and inflammatory responses contribute. Peroxisome proliferator-activated receptors-gamma (PPARgamma) agonists have both anti-proliferative and anti-inflammatory properties. We tested the effect of therapeutic doses of rosiglitazone on proliferative and inflammatory pathways in ...<br/><br/>Anna Solini, Eleonora Santini, Stephanie Madec, Monica Nannipieri, Alessandra Bonotti, Sabina Cuccato, Ele Ferrannini (2008) <i>Diabetes Metab Res Rev</i> <i></i> <i></i> 24: 3 197-204<br/>

http://publicationslist.org/anna.solini/refid11 2010-02-23T15:10:46Z

BACKGROUND AND AIMS: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. METHODS AND RESULTS: A database of non-diabetic Italian subjects has recently been set up using data from hyperinsulinemic euglycemic clamp studies carried out using the standard technique (40 mU per min per squ...<br/><br/>Enzo Bonora, Brunella Capaldo, Paolo Cavallo Perin, Stefano Del Prato, Giancarlo De Mattia, Lucia Frittitta, Simona Frontoni, Frida Leonetti, Livio Luzi, Giulio Marchesini, Maria Adelaide Marini, Andrea Natali, Giuseppe Paolisso, Pier Marco Piatti, Arturo Pujia, Anna Solini, Roberto Vettor, Riccardo C Bonadonna (2008) <i>Nutr Metab Cardiovasc Dis</i> <i></i> <i></i> 18: 9 624-631<br/>

http://publicationslist.org/anna.solini/refid8 2010-02-23T15:10:46Z

Hypercholesterolemia and Type 2 diabetes are well-recognized risk factors for cardiovascular disease, promoted by a condition of subclinical inflammation and a hypercoagulable state. Soluble CD40 ligand (sCD40L), a marker of vascular inflammation, seems to predict vascular damage in patients with Type 2 diabetes. Beside the lipid-lowering effect, statins seem to slow the progression of atheroscler...<br/><br/>E Santini, S Madec, V Corretti, E Ferrannini, A Solini (2008) <i>J Endocrinol Invest</i> <i></i> <i></i> 31: 7 660-665<br/>

http://publicationslist.org/anna.solini/refid9 2010-02-23T15:10:46Z

AIMS/HYPOTHESIS: Inflammation is a mechanism of glomerular damage in chronic glomerulopathies. LDL may increase the production of inflammatory cytokines in renal tissues. However, the relative role of native, oxidised and glycated LDL in promoting this process has been only partially elucidated. METHODS: We tested the inflammatory and proapoptotic effects of native, oxidised and glycated LDL in hu...<br/><br/>E Santini, R Lupi, S Baldi, S Madec, D Chimenti, E Ferrannini, A Solini (2008) <i>Diabetologia</i> <i></i> <i></i> 51: 11 2117-2125<br/>

http://publicationslist.org/anna.solini/refid16 2010-02-23T15:10:46Z

Elevated intraocular pressure may lead to retinal ganglion cell injury and consequent visual deficits. Chronic intraocular pressure increase is a major risk factor for glaucoma, a leading blinding disease, and permanent visual deficits can also occur following acute pressure increments due to trauma, acute glaucoma or refractive surgery. How pressure affects retinal neurons is not firmly establish...<br/><br/>Valentina Resta, Elena Novelli, Giovanni Vozzi, Cristiano Scarpa, Matteo Caleo, Arti Ahluwalia, Anna Solini, Eleonora Santini, Vincenzo Parisi, Francesco Di Virgilio, Lucia Galli-Resta (2007) <i>Eur J Neurosci</i> <i></i> <i></i> 25: 9 2741-2754<br/>

http://publicationslist.org/anna.solini/refid17 2010-02-23T15:10:46Z

Apoptosis, a normal event in renal tissue homeostasis, has been considered as a major mechanism for either resolution of glomerular hypercellularity in glomerulonephritis or loss of cellularity and progression to glomerulosclerosis in chronic renal disease. This study was aimed at investigating the role of extracellular ATP (eATP) in mediating apoptosis in human mesangial cells (HMC) and identifyi...<br/><br/>Anna Solini, Eleonora Santini, Daniele Chimenti, Paola Chiozzi, Federico Pratesi, Sabina Cuccato, Simonetta Falzoni, Roberto Lupi, Ele Ferrannini, Giuseppe Pugliese, Francesco Di Virgilio (2007) <i>Am J Physiol Renal Physiol</i> <i></i> <i></i> 292: 5 F1537-F1547<br/>

http://publicationslist.org/anna.solini/refid15 2010-02-23T15:10:46Z

Andrea Lo Monaco, Sara Gulinelli, Gabriella Castellino, Anna Solini, Davide Ferrari, Renato La Corte, Francesco Trotta, Francesco Di Virgilio (2007) <i>Ann Rheum Dis</i> <i></i> <i></i> 66: 8 1124-1125<br/>

http://publicationslist.org/anna.solini/refid10 2010-02-23T15:10:46Z

Endothelin-1 (ET-1) promotes the contractile ability of fibroblasts, essential for wound closure and reconstitution of the dermis. Wound healing is impaired in type 2 diabetic patients (D). We compared the effect of ET-1 on proliferative transforming growth factor (TGFbeta(1)) expression, fibronectin and laminin release), differentiative [alpha-smooth muscle actin (alpha-SMA) expression] and infla...<br/><br/>Anna Solini, Eleonora Santini, Stephanie Madec, Sabina Cuccato, Ele Ferrannini (2007) <i>Growth Factors</i> <i></i> <i></i> 25: 6 392-399<br/>

http://publicationslist.org/anna.solini/refid14 2010-02-23T15:10:46Z

Giorgio Sesti, Brunella Capaldo, Paolo Cavallo Perin, Stefano Del Prato, Lucia Frittitta, Simona Frontoni, Marta Letizia Hribal, Giulio Marchesini, Giuseppe Paolisso, Pier Marco Piatti, Anna Solini, Enzo Bonora (2007) <i>Diabetes Care</i> <i></i> <i></i> 30: 5 <br/>

http://publicationslist.org/anna.solini/refid20 2010-02-23T15:10:46Z

OBJECTIVE: Inflammation plays a pivotal role in the atherosclerotic process, and some chemokines seem to be crucial in the pathogenesis of vascular damage. High-serum homocysteine, recently recognized as an independent risk factor for vascular disease might increase cytokine and chemokine levels, thus amplifying endothelial damage; moreover, it might worse insulin resistance, thus further contribu...<br/><br/>A Solini, E Santini, E Ferrannini (2006) <i>Int J Obes (Lond)</i> <i></i> <i></i> 30: 8 1197-1202<br/>

http://publicationslist.org/anna.solini/refid19 2010-02-23T15:10:46Z

Alterations in electrolyte balance have been claimed to play a role in the pathophysiology of coronary heart disease; however, the relationship between the electrolyte pattern and other clinical variables immediately after an acute vascular event is unclear. The aim of the present study was to test whether electrolyte and microelement changes characterize the acute phase in patients with different...<br/><br/>A Solini, P Zamboni, A Passaro, R Fellin, E Ferrannini (2006) <i>Horm Metab Res</i> <i></i> <i></i> 38: 3 197-202<br/>

http://publicationslist.org/anna.solini/refid18 2010-02-23T15:10:46Z

AIMS/HYPOTHESIS: Atherosclerosis is particularly aggressive in patients with diabetes. Hyperhomocysteinaemia causes oxidative stress and cytokine secretion: its atherogenic effect is mediated by an enhanced inflammatory response. Matrix metalloproteinases (MMPs) regulate extracellular matrix degradation and remodelling, and contribute to the vulnerability of the atherosclerotic lesion. Fibroblasts...<br/><br/>A Solini, E Santini, M Nannipieri, E Ferrannini (2006) <i>Diabetologia</i> <i></i> <i></i> 49: 10 2499-2506<br/>

http://publicationslist.org/anna.solini/refid25 2010-02-23T15:10:46Z

OBJECTIVE: Familial hypercholesterolemia (FH) is characterized by a high incidence of coronary heart disease. Evidence suggests an important role for angiotensin II (AngII) in the fibrotic response to tissue injury, and in promoting myocardial hypertrophy via paracrine mechanisms mediated by fibroblasts. We sought to determine whether AngII promotes proliferative and pro-atherogenic responses in F...<br/><br/>Anna Solini, Eleonora Santini, Ele Ferrannini (2005) <i>J Hypertens</i> <i></i> <i></i> 23: 2 367-374<br/>

http://publicationslist.org/anna.solini/refid24 2010-02-23T15:10:46Z

BACKGROUND: Extracellular adenosine triphosphate (ATP) (eATP) mediates several biologic activities via purinergic P2 receptors (P2Rs). This study aimed at (1) evaluating the role of the purinergic system in modulating mesangial extracellular matrix (ECM) and transforming growth factor-beta (TGF-beta) production and (2) its contribution to diabetes-induced mesangial ECM accumulation. METHODS: Rat m...<br/><br/>Anna Solini, Carla Iacobini, Carlo Ricci, Paola Chiozzi, Lorena Amadio, Flavia Pricci, Umberto Di Mario, Francesco Di Virgilio, Giuseppe Pugliese (2005) <i>Kidney Int</i> <i></i> <i></i> 67: 3 875-885<br/>

http://publicationslist.org/anna.solini/refid23 2010-02-23T15:10:46Z

We investigated the presence of P2 receptors (P2Rs) in human thyrocytes and their possible involvement in the modulation of cytokine release. P2Rs expression was assessed by RT-PCR and, when possible, by immunoblotting. Human primary thyrocytes express the mRNA for the following P2X and P2Y subtypes: P2X(3), P2X(5), P2X(6), P2X(7), and P2Y(1), P2Y(2), P2Y(4), and P2Y(11). Stimulation with extracel...<br/><br/>Nadia Caraccio, Fabio Monzani, Eleonora Santini, Sabina Cuccato, Davide Ferrari, Maria Giulia Callegari, Sara Gulinelli, Cinzia Pizzirani, Francesco Di Virgilio, Ele Ferrannini, Anna Solini (2005) <i>Endocrinology</i> <i></i> <i></i> 146: 7 3172-3178<br/>

http://publicationslist.org/anna.solini/refid21 2010-02-23T15:10:46Z

Type 2 diabetes is reaching epidemic proportions throughout the world, representing the most common cause of ESRD. Early identification of renal impairment associated with diabetes and initiation of renoprotective therapy are imperative. High BP, dyslipidemia, long duration of diabetes, and poor glycemic control are important risk factors; their modification, renal function monitoring, and combine...<br/><br/>Paola Fioretto, Anna Solini (2005) <i>J Am Soc Nephrol</i> <i></i> <i></i> 16 Suppl 1: S18-S21<br/>

http://publicationslist.org/anna.solini/refid22 2010-02-23T15:10:46Z

OBJECTIVE: Insulin activates several processes potentially dangerous for the arterial wall and hyperinsulinemia might be atherogenic. However, other insulin effects are protective for the vessel wall and thus anti-atherogenic. Aim of this study was to investigate whether insulin effects on potentially pro-atherogenic and anti-atherogenic processes were differently affected in cells from insulin-re...<br/><br/>Assunta Pandolfi, Anna Solini, Giuliana Pellegrini, Gabriella Mincione, Sara Di Silvestre, Paola Chiozzi, Annalisa Giardinelli, Maria Carmela Di Marcantonio, Alessandro Piccirelli, Fabio Capani, Agostino Consoli (2005) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 25: 11 2392-2397<br/>

http://publicationslist.org/anna.solini/refid26 2010-02-23T15:10:46Z

OBJECTIVE: Recent prospective studies have identified hyperlipidaemia as an independent determinant of diabetic nephropathy. Lipoprotein lipase (LPL) is a key enzyme in the postprandial processing of triglycerides and VLDL. Among a number of common sequence variants of the LPL, HindIII has been associated with coronary heart disease and, more recently, with microalbuminuria in type 2 diabetes. We ...<br/><br/>A Solini, A Passaro, P Fioretto, M Nannipieri, E Ferrannini (2004) <i>J Intern Med</i> <i></i> <i></i> 256: 1 30-36<br/>

http://publicationslist.org/anna.solini/refid27 2010-02-23T15:10:46Z

OBJECTIVE: We have investigated expression and function of the P2X7 receptor in fibroblasts from healthy subjects and patients with type 2 diabetes. METHODS AND RESULTS: Fibroblasts were isolated from skin biopsies. P2X7 receptor expression in both cell populations was measured by functional assays, RT-PCR, fluorescence-activated cell sorter, and immunoblotting. We found that fibroblasts from diab...<br/><br/>Anna Solini, Paola Chiozzi, Anna Morelli, Elena Adinolfi, Roberta Rizzo, Olavio R Baricordi, Francesco Di Virgilio (2004) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 24: 7 1240-1245<br/>

http://publicationslist.org/anna.solini/refid31 2010-02-23T15:10:46Z

Familial predisposition together with several environmental factors may be involved in the pathogenesis of common prostate disease such as benign hypertrophy or prostate neoplasm. A higher incidence of both these conditions has been described in some insulin-resistant states such as obesity, but not much information is available on the effect of metabolic profile on gland morphology. The aim of th...<br/><br/>P F Zamboni, M Simone, A Passaro, E Doh Dalla Nora, R Fellin, A Solini (2003) <i>Horm Metab Res</i> <i></i> <i></i> 35: 5 296-300<br/>

http://publicationslist.org/anna.solini/refid30 2010-02-23T15:10:46Z

OBJECTIVES: Hyperhomocysteinaemia has emerged as a novel risk factor for cardiovascular disease. The determinants of total homocysteine (tHcy) levels in type 2 diabetic patients (D2p) have not been studied in detail. We examined prospectively the effect of different degrees of metabolic control on plasma tHcy in D2p with preserved kidney function. SUBJECTS AND MAIN OUTCOME MEASUREMENTS: Ninety-fiv...<br/><br/>A Passaro, F Calzoni, S Volpato, E Dalla Nora, P L Pareschi, P F Zamboni, R Fellin, A Solini (2003) <i>J Intern Med</i> <i></i> <i></i> 254: 3 264-271<br/>

http://publicationslist.org/anna.solini/refid29 2010-02-23T15:10:46Z

OBJECTIVE: To study the relationships between the PC-1 K121Q variant and diabetic nephropathy (DN) in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A total of 125 patients with type 2 diabetes and abnormal albumin excretion rate (AER) (range 20-5416 microg/min) were followed up for 4 years with repeated measurements of glomerular filtration rate (GFR). Genomic DNA was extracted from ...<br/><br/>Salvatore De Cosmo, Roberto Trevisan, Michele Dalla Vestra, Monica Vedovato, Alessandra Argiolas, Anna Solini, Alois Saller, Francesco Damone, Antonio Tiengo, Vincenzo Trischitta, Paola Fioretto (2003) <i>Diabetes Care</i> <i></i> <i></i> 26: 10 2898-2902<br/>

http://publicationslist.org/anna.solini/refid28 2010-02-23T15:10:46Z

Extracellular ATP is an ubiquitous mediator that regulates several cellular functions via specific P2 plasma membrane receptors (P2Rs), for which a role in modulating intracellular glucose metabolism has been recently suggested. We have investigated glucose uptake in response to P2Rs stimulation in fibroblasts from type 2 diabetic (T2D) patients and control subjects. P2Rs expression was evaluated ...<br/><br/>Anna Solini, Paola Chiozzi, Anna Morelli, Angela Passaro, Renato Fellin, Francesco Di Virgilio (2003) <i>J Cell Physiol</i> <i></i> <i></i> 197: 3 435-444<br/>

http://publicationslist.org/anna.solini/refid32 2010-02-23T15:10:46Z

Several pieces of evidence support a role of inflammatory processes in the pathogenesis of atherosclerosis; it is also known that endothelial dysfunction is the initial lesion of the atherosclerotic process. Among other markers of endothelial dysfunction, some adhesion molecules seem to play an interesting role. The aim of the present study was to evaluate the effect of atorvastatin vs placebo on ...<br/><br/>E Dalla Nora, A Passaro, P F Zamboni, F Calzoni, R Fellin, A Solini (2003) <i>J Endocrinol Invest</i> <i></i> <i></i> 26: 1 73-78<br/>

http://publicationslist.org/anna.solini/refid33 2010-02-23T15:10:46Z

Atherosclerosis is a focal inflammatory disease of the arterial wall. It starts with the formation of fatty streaks on the arterial wall that evolve to form a raised plaque made of smooth muscle cells (SMCs), and infiltrating leukocytes surrounding a necrotic core. The pathogenesis of the atherosclerotic lesion is incompletely understood, but it is clear that a dysfunction of the endothelium, recr...<br/><br/>Francesco Di Virgilio, Anna Solini (2002) <i>Br J Pharmacol</i> <i></i> <i></i> 135: 4 831-842<br/>

http://publicationslist.org/anna.solini/refid34 2010-02-23T15:10:46Z

Genetic factors are important in conferring diabetic nephropathy (DN) risk. The insertion/deletion (I/D) polymorphism of the ACE gene has been described to be associated with DN risk and progression. The renal lesions underlying DN in type 2 diabetes are heterogeneous; only a subset of patients, characterized by a faster decline of renal function, have diabetic glomerulopathy. This study explored ...<br/><br/>Anna Solini, M Dalla Vestra, Alois Saller, Romano Nosadini, Gaetano Crepaldi, Paola Fioretto (2002) <i>Diabetes</i> <i></i> <i></i> 51: 1 251-255<br/>

http://publicationslist.org/anna.solini/refid38 2010-02-23T15:10:46Z

A subgroup of patients with type 2 diabetes shows a clustering of abnormalities such as peripheral insulin resistance, hypertension, and microalbuminuria. To evaluate whether these traits reflect intrinsic disorders of cell function rather than in vivo environmental effects, we studied a group of 7 nondiabetic hypertensive subjects with an altered albumin excretion rate (AER) (HyMA+) and 3 groups ...<br/><br/>A Solini, F Di Virgilio, P Chiozzi, P Fioretto, A Passaro, R Fellin (2001) <i>Hypertension</i> <i></i> <i></i> 37: 6 1492-1496<br/>

http://publicationslist.org/anna.solini/refid37 2010-02-23T15:10:46Z

Plasma homocysteine (Hcy) is an independent vascular risk factor. Its remethylation to methionine is regulated by the activity of the enzyme 5,10-methylene tetrahydrofolate reductase (MTHFR). A C-to-T substitution at nucleotide 677 of the MTHFR gene is frequently associated to hyperhomocysteinemia. In this study, we evaluated the relationship among MTHFR C677T polymorphism, Hcy and some ultrasonog...<br/><br/>A Passaro, A Vanini, F Calzoni, L Alberti, P F Zamboni, R Fellin, A Solini (2001) <i>Atherosclerosis</i> <i></i> <i></i> 157: 1 175-180<br/>

http://publicationslist.org/anna.solini/refid36 2010-02-23T15:10:46Z

BACKGROUND: Leptin, the product of the ob gene, could have a significant role in the pathogenesis of obesity and non-insulin-dependent diabetes mellitus. However, it is still debated whether different degrees of glucose tolerance may affect plasma leptin concentrations in obese patients. OBJECTIVE: To investigate whether diabetes might influence leptin concentrations in obese patients. METHODS: We...<br/><br/>A Passaro, F Calzoni, P F Zamboni, D Manservigi, L Alberti, E Dalla Nora, R Fellin, A Solini (2001) <i>Eur J Endocrinol</i> <i></i> <i></i> 145: 2 173-179<br/>

http://publicationslist.org/anna.solini/refid35 2010-02-23T15:10:46Z

The ACE gene is a candidate gene for cardiovascular disease. Endothelial dysfunction is considered an intermediate phenotype in the pathogenesis of hypertension and atherosclerosis. We evaluated the role of ACE gene polymorphism in endothelial function of young healthy humans. We assessed ACE genotype (deletion [D]/insertion [I] polymorphism) in 92 young healthy individuals. In 88 of them, endothe...<br/><br/>G Arcaro, A Solini, T Monauni, A Cretti, B Brunato, A Lechi, R Fellin, M Caputo, C Cocco, E Bonora, M Muggeo, R C Bonadonna (2001) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 21: 8 1313-1319<br/>

http://publicationslist.org/anna.solini/refid41 2010-02-23T15:10:46Z

A Passaro, K D'Elia, P L Pareschi, F Calzoni, M Carantoni, R Fellin, A Solini (2000) <i>Diabetes Care</i> <i></i> <i></i> 23: 3 420-421<br/>

http://publicationslist.org/anna.solini/refid40 2010-02-23T15:10:46Z

Plasma glucose has been regarded as a risk factor for macrovascular complications in diabetes, but less is known about its role in the development of cardiac impairment other than coronary heart disease (CHD). The aim of our study was to determine the relationship between basal and post-OGTT (Oral Glucose Tolerance Test) plasma glucose levels and some ECG parameters in a group of elderly women wit...<br/><br/>A Solini, A Passaro, K D'Elia, F Calzoni, L Alberti, R Fellin (2000) <i>Aging (Milano)</i> <i></i> <i></i> 12: 4 249-255<br/>

http://publicationslist.org/anna.solini/refid39 2010-02-23T15:10:46Z

AIMS/HYPOTHESIS: Purinergic receptors are a family of newly characterized plasma membrane molecules involved in several and as yet only partially known cellular functions such as vascular reactivity, apoptosis and cytokine secretion. Little is known about the effect extracellular microenvironment has on their function. Fibroblasts share several features with smooth muscle cells and are an importan...<br/><br/>A Solini, P Chiozzi, S Falzoni, A Morelli, R Fellin, F Di Virgilio (2000) <i>Diabetologia</i> <i></i> <i></i> 43: 10 1248-1256<br/>

http://publicationslist.org/anna.solini/refid42 2010-02-23T15:10:46Z

Familial clustering of altered albumin excretion and nephropathy risk has been described in both type 1 and type 2 diabetes; moreover, an association of micro-macroalbuminuria and diabetic retinopathy has been recently reported in a large number of white families with type 2 diabetes. Conflicting reports, mainly comparing affected with unaffected unrelated subjects, have suggested a possible role ...<br/><br/>A Solini, G Giacchetti, A Sfriso, P Fioretto, C Sardu, A Saller, G Tonolo, M Maioli, F Mantero, R Nosadini (1999) <i>Am J Kidney Dis</i> <i></i> <i></i> 34: 6 1002-1009<br/>

http://publicationslist.org/anna.solini/refid43 2010-02-23T15:10:46Z

We have investigated reponses to extracellular ATP in human fibroblasts obtained by skin biopsies. Our data show that these cells express a P2X7 purinergic receptor, as judged by (1) RT-PCR with specific primers, (2) reactivity with a specific anti-P2X7 antiserum, (3) activation by the selective P2X agonist benzoylbenzoylATP and (4) stimulation of transmembrane ion fluxes. Stimulation with benzoyl...<br/><br/>A Solini, P Chiozzi, A Morelli, R Fellin, F Di Virgilio (1999) <i>J Cell Sci</i> <i></i> <i></i> 112 ( Pt 3): 297-305<br/>

http://publicationslist.org/anna.solini/refid45 2010-02-23T15:10:46Z

In poorly controlled diabetics, the whole-body protein flux is increased by 20-30% in comparison to well-controlled type I diabetes (IDDM) and normal subjects. Intensive insulin administration completely reverses these abnormalities. In poorly controlled IDDM, the primary effect of insulin administration is to reduce the increased protein catabolic rate by suppressing the accelerated rate of prote...<br/><br/>P Castellino, M Giordano, E de Pascale, A Solini (1998) <i>Miner Electrolyte Metab</i> <i></i> <i></i> 24: 1 41-46<br/>

http://publicationslist.org/anna.solini/refid44 2010-02-23T15:10:46Z

Membrane glycoprotein PC-1 inhibits insulin receptor (IR) tyrosine kinase activity and subsequent cellular signaling. PC-1 content is elevated in muscle and adipose tissue from insulin-resistant subjects, and its elevation correlates with in vivo insulin resistance. To determine whether elevated PC-1 content is a primary cause of insulin resistance, we have now measured PC-1 content in cultured sk...<br/><br/>L Frittitta, D Spampinato, A Solini, R Nosadini, I D Goldfine, R Vigneri, V Trischitta (1998) <i>Diabetes</i> <i></i> <i></i> 47: 7 1095-1100<br/>

http://publicationslist.org/anna.solini/refid47 2010-02-23T15:10:46Z

It is controversial whether metabolic disorders of human obesity include protein metabolism. Even less information is available concerning the effect of fat distribution on protein metabolism. Therefore, a comprehensive evaluation of glucose, lipid, and protein metabolism was performed in 11 obese nondiabetic and 9 normal women whose body composition and regional fat distribution were determined. ...<br/><br/>A Solini, E Bonora, R Bonadonna, P Castellino, R A DeFronzo (1997) <i>J Clin Endocrinol Metab</i> <i></i> <i></i> 82: 8 2552-2558<br/>

http://publicationslist.org/anna.solini/refid48 2010-02-23T15:10:46Z

OBJECTIVE: To determine the effect of oral administration of glycosaminoglycans on metabolic control and albumin excretion rate (AER) in NIDDM patients with increased urinary albumin excretion. RESEARCH DESIGN AND METHODS: Twelve NIDDM hypertensive patients (age 52 +/- 3 years, HbA1c 7.7 +/- 0.2%) on antihypertensive treatment were enrolled in a double-blind placebo-controlled study, assuming eith...<br/><br/>A Solini, L Vergnani, F Ricci, G Crepaldi (1997) <i>Diabetes Care</i> <i></i> <i></i> 20: 5 819-823<br/>

http://publicationslist.org/anna.solini/refid46 2010-02-23T15:10:46Z

We measured erythrocyte Na+/Li+ and Na+/H+ countertransport (CT) activity (millimoles per liter per cell per hour) in 10 healthy control subjects (age, 38 +/- 4 years; body mass index, 25 +/- 1 kg/m2) and in 25 hypertensive patients with non-insulin-dependent diabetes mellitus ([NIDDM] age, 49 +/- 3 years; body mass index, 29 +/- 1 kg/m2; fasting plasma glucose, 157 +/- 12 mg/dL) 4 weeks after dis...<br/><br/>M Giordano, P Castellino, A Solini, M L Canessa, R A DeFronzo (1997) <i>Metabolism</i> <i></i> <i></i> 46: 11 1316-1323<br/>

http://publicationslist.org/anna.solini/refid49 2010-02-23T15:10:46Z

Intracellular calcium ([(Ca2+)i]) plays a role in many cellular functions, and is involved in the pathogenesis of some conditions observed in non-insulin dependent diabetic patients (NIDDM), such as hypertension and insulin resistance. Hyperinsulinemia and hyperglycemia are also implicated in the pathogenesis of chronic diabetes complications. It is not clear whether disturbances in [(Ca2+)i] are ...<br/><br/>A Solini, F Di Virgilio, A Sfriso, M Bruseghin, G Crepaldi, R Nosadini (1996) <i>Kidney Int</i> <i></i> <i></i> 50: 2 618-626<br/>

http://publicationslist.org/anna.solini/refid50 2010-02-23T15:10:46Z

OBJECTIVE--The purpose of this research was to compare insulin sensitivity in Mexican-Americans and non-Hispanic whites without a family history of diabetes to establish whether insulin resistance is a defect intrinsically related to subjects of Mexican origin. RESEARCH DESIGN AND METHODS--In study A, we compared insulin sensitivity in 12 Mexican-American and 12 non-Hispanic white women with norma...<br/><br/>E Bonora, G Gulli, R Bonadonna, S Del Prato, A Solini, R A DeFronzo (1995) <i>Diabetes Care</i> <i></i> <i></i> 18: 6 825-833<br/>

http://publicationslist.org/anna.solini/refid53 2010-02-23T15:10:46Z

Insulin resistance may be a mechanism linking non-insulin-dependent diabetes mellitus (NIDDM) to hypertension and cardiovascular mortality. Microalbuminuria also is an independent risk factor of cardiovascular mortality and of hypertension. Little information is available in the literature on the relationship between microalbuminuria and insulin action. This study investigated the relationships be...<br/><br/>R Nosadini, A Solini, M Velussi, B Muollo, F Frigato, M Sambataro, M R Cipollina, F De Riva, E Brocco, G Crepaldi (1994) <i>Diabetes</i> <i></i> <i></i> 43: 3 491-499<br/>

http://publicationslist.org/anna.solini/refid52 2010-02-23T15:10:46Z

Microalbuminuria, hypertension and hyperinsulinaemia are three independent risk factors for cardiac disease in non insulin-dependent diabetes (NIDDM). However, it is unknown to what extent hyperinsulinaemia reflects resistance to insulin action at hepatic, extrahepatic or at both sites. A cross-sectional study from our Department showed that peripheral insulin resistance, hypertension, microalbumi...<br/><br/>R Nosadini, E Manzato, A Solini, P Fioretto, E Brocco, S Zambon, A Morocutti, M Sambataro, M Velussi, M R Cipollina (1994) <i>Eur J Clin Invest</i> <i></i> <i></i> 24: 4 258-266<br/>

http://publicationslist.org/anna.solini/refid51 2010-02-23T15:10:46Z

We investigated whether specific lipoprotein abnormalities are present in non-insulin-dependent diabetes mellitus (NIDDM) patients with hypertension and/or microalbuminuria. Fifteen normotensive normoalbuminuric (H-M-), 32 hypertensive normoalbuminuric (H+M-), and 22 hypertensive microalbuminuric (H+M+) NIDDM patients and 20 sex-, age-, and weight-matched nondiabetic control subjects were studied....<br/><br/>S Zambon, E Manzato, A Solini, M Sambataro, E Brocco, G Sartore, G Crepaldi, R Nosadini (1994) <i>Arterioscler Thromb</i> <i></i> <i></i> 14: 6 911-916<br/>

http://publicationslist.org/anna.solini/refid56 2010-02-23T15:10:46Z

This study examined whether the presence of hypertension, an insulin-resistant condition, exacerbates the defect in insulin action observed in obesity and type II diabetes mellitus. Glucose metabolism in the basal state and in response to insulin was quantitated by using the euglycemic insulin (20 mU.min-1 x m-2) clamp in combination with 3-[3H]glucose infusion and indirect calorimetry in 20 obese...<br/><br/>E Bonora, R C Bonadonna, S Del Prato, G Gulli, A Solini, M Matsuda, R A DeFronzo (1993) <i>Diabetes</i> <i></i> <i></i> 42: 5 764-772<br/>

http://publicationslist.org/anna.solini/refid57 2010-02-23T15:10:46Z

Seven non-insulin-dependent diabetes mellitus (NIDDM) patients participated in three clamp studies performed with [3-3H]- and [U-14C]glucose and indirect calorimetry: study I, euglycemic (5.2 +/- 0.1 mM) insulin (269 +/- 39 pM) clamp; study II, hyperglycemic (14.9 +/- 1.2 mM) insulin (259 +/- 19 pM) clamp; study III, euglycemic (5.5 +/- 0.3 mM) hyperinsulinemic (1650 +/- 529 pM) clamp. Seven contr...<br/><br/>S Del Prato, R C Bonadonna, E Bonora, G Gulli, A Solini, M Shank, R A DeFronzo (1993) <i>J Clin Invest</i> <i></i> <i></i> 91: 2 484-494<br/>

http://publicationslist.org/anna.solini/refid55 2010-02-23T15:10:46Z

Sodium retention has been advocated to give rise to hypertension in humans. Increases in blood glucose and insulin concentrations ensue in the stimulation of sodium reabsorption by the kidney. Although the combined occurrence of hyperglycemia and hyperinsulinemia, frequently secondary to insulin resistance with regard to carbohydrate metabolism, is a hallmark of non-insulin dependent diabetes (NID...<br/><br/>R Nosadini, M Sambataro, K Thomaseth, G Pacini, M R Cipollina, E Brocco, A Solini, A Carraro, M Velussi, F Frigato (1993) <i>Kidney Int</i> <i></i> <i></i> 44: 1 139-146<br/>

http://publicationslist.org/anna.solini/refid54 2010-02-23T15:10:46Z

Methodology for assessing the glycolytic and oxidative fluxes from plasma glucose, by measuring 3H2O and 14CO2 rates of production during [3-3H]- and [U-14C]glucose infusion, was tested in healthy subjects. In study 1, during staircase 3H2O infusion in six subjects, calculated rates of 3H2O appearance agreed closely with 3H2O infusion rates. In study 2, when [2-3H]glucose and NaH14CO3 were infused...<br/><br/>R C Bonadonna, S del Prato, E Bonora, G Gulli, A Solini, R A DeFronzo (1993) <i>Am J Physiol</i> <i></i> <i></i> 265: 6 Pt 1 E943-E953<br/>

http://publicationslist.org/anna.solini/refid60 2010-02-23T15:10:46Z

We have quantitatively assessed the percentage of lower limb arterio-venous (a-v) shunting using a radioisotopic technique and correlated it with autonomic neuropathy evaluated by cardiovascular tests. We have studied three groups of diabetic patients: Group A, 12 non-neuropathic subjects without foot lesions; Group B, 12 neuropathic subjects without foot lesions; Group C, 12 neuropathic subjects ...<br/><br/>L Uccioli, L Mancini, A Giordano, A Solini, P Magnani, A Manto, P Cotroneo, A V Greco, G Ghirlanda (1992) <i>Diabetes Res Clin Pract</i> <i></i> <i></i> 16: 2 123-130<br/>

http://publicationslist.org/anna.solini/refid61 2010-02-23T15:10:46Z

The effects of hyperinsulinemia and hyperaminoacidemia on glucose and amino acid metabolism were examined in 16 control and 13 chronic renal failure (CRF) patients under two conditions: 1) euglycemic hyperinsulinemia and 2) amino acid infusion. All studies were performed with continuous indirect calorimetry and [1-14C]leucine infusion. In CRF patients insulin-mediated whole body glucose metabolism...<br/><br/>P Castellino, A Solini, L Luzi, J G Barr, D J Smith, A Petrides, M Giordano, C Carroll, R A DeFronzo (1992) <i>Am J Physiol</i> <i></i> <i></i> 262: 2 Pt 2 F168-F176<br/>

http://publicationslist.org/anna.solini/refid59 2010-02-23T15:10:46Z

In this study, total body fat content and fat topography were related to glucose metabolism in the basal and insulin-stimulated states in 18 nonobese and 18 obese premenopausal nondiabetic women. All subjects received a euglycemic insulin (20 mU.min-1.m2) clamp study in combination with [3-3H]-D-glucose infusion and indirect calorimetry to quantitate total body glucose uptake, glucose oxidation, a...<br/><br/>E Bonora, S Del Prato, R C Bonadonna, G Gulli, A Solini, M L Shank, A A Ghiatas, J L Lancaster, R F Kilcoyne, A M Alyassin (1992) <i>Diabetes</i> <i></i> <i></i> 41: 9 1151-1159<br/>

http://publicationslist.org/anna.solini/refid58 2010-02-23T15:10:46Z

The aim of this study was to investigate the relationships among insulin resistance and albumin excretion rate in 25 nondiabetic patients with essential hypertension and in 28 patients with non-insulin dependent diabetes mellitus (NIDDM). Two groups of healthy subjects matched for age, sex, and weight served as controls. Patients with essential hypertension were divided into two subgroups: without...<br/><br/>R Nosadini, M R Cipollina, A Solini, M Sambataro, A Morocutti, A Doria, P Fioretto, E Brocco, B Muollo, F Frigato (1992) <i>J Am Soc Nephrol</i> <i></i> <i></i> 3: 4 Suppl S56-S63<br/>

http://publicationslist.org/anna.solini/refid62 2010-02-23T15:10:46Z

G Nanni, A Solini, P Cotroneo, G Ghirlanda, A Scotti, M Castagneto (1990) <i>Transplant Proc</i> <i></i> <i></i> 22: 5 2280-2281<br/>

http://publicationslist.org/anna.solini/refid63 2010-02-23T15:10:46Z

The rate at which somatostatin appears in the circulation after subcutaneous bolus injection and continuous administration by pump was determined in normal subjects by serial radioimmunoassays of immunoreactive somatostatin. Following a single subcutaneous injection of 250 micrograms, the somatostatin peak in plasma appeared after 5 min and had only a transient effect on insulin levels. During con...<br/><br/>L Uccioli, G Ghirlanda, P Cotroneo, A Manto, A Solini, A V Greco (1986) <i>Acta Endocrinol (Copenh)</i> <i></i> <i></i> 113: 4 465-470<br/>

http://publicationslist.org/anna.solini/refid64 2010-02-23T15:10:46Z

Somatostatin has been proposed as a regulatory peptide of nutrient entry and fuel homeostasis because of its ability to inhibit the release of substances involved in food digestion and metabolism. The aim of the study was to evaluate the somatostatin response to a test meal in type I diabetics at the clinical onset of the disease and after two months of intensive insulin therapy. Normal subjects a...<br/><br/>L Uccioli, G Ghirlanda, P Cotroneo, G Bianchini, A Manto, A Solini, V Annese, A V Greco (1986) <i>Peptides</i> <i></i> <i></i> 7 Suppl 1: 287-291<br/>