Annika Jögi's Publications List

HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells.

2016-05-16T18:09:36Z

The majority of breast cancers express estrogen receptor α (ERα), and most patients with ERα-positive breast cancer benefit from antiestrogen therapy. The ERα-modulator tamoxifen and ERα-downregulator fulvestrant are commonly employed antiestrogens. Antiestrogen resistance remains a clinical challenge, with few effective treatments available for patients with antiestrogen-resistant breast can...

Muhammad Wasi Alam, Camilla Ulrika Persson, Susann Reinbothe, Julhash U Kazi, Lars Rönnstrand, Caroline Wigerup, Henrik Jorn Ditzel, Anne E Lykkesfeldt, Sven Påhlman, Annika Jögi (2016) Oncotarget 7: 10 11238-11250

Hypoxia down-regulates expression of Secretory Leukocyte Protease Inhibitor in bronchial epithelial cells via TGF-beta1

2015-02-05T13:56:42Z

L I Påhlman, A JÖgi, M Gram, M Mori, A Egesten (2015) BMC Pulmonary Medicine :

Spontaneous lung and lymph node metastasis in transgenic breast cancer is independent of the urokinase receptor uPAR.

2016-05-16T18:08:26Z

Urokinase-type plasminogen activator (uPA) is an extracellular protease that plays a pivotal role in tumor progression. uPA activity is spatially restricted by its anchorage to high-affinity uPA receptors (uPAR) at the cell surface. High tumor tissue expression of uPA and uPAR is associated with poor prognosis in lung, breast, and colon cancer patients in clinical studies. Genetic deficiency of uP...

Kasper Almholt, Ole Didrik Lærum, Boye Schnack Nielsen, Ida Katrine Lund, Leif Røge Lund, John Rømer, Annika Jögi (2015) Clinical & experimental metastasis 32: 6 543-554

Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution.

2016-05-16T18:08:26Z

The development and functional cycle of the mammary gland involves a number of processes that are caricatured by breast cancer cells during invasion and metastasis. Expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 has been associated with metastatic, poor prognosis, and high-grade breast cancers. Since hypoxia affects normal epithelial differentiation, we hypothesise that ...

Sven Påhlman, Leif R Lund, Annika Jögi (2015) PloS one 10: 5

EPO-independent functional EPO receptor in breast cancer enhances estrogen receptor activity and promotes cell proliferation.

2014-07-10T09:25:40Z

The main function of Erythropoietin (EPO) and its receptor (EPOR) is the stimulation of erythropoiesis. Recombinant human EPO (rhEPO) is therefore used to treat anemia in cancer patients. However, clinical trials have indicated that rhEPO treatment might promote tumor progression and has a negative effect on patient survival. In addition, EPOR expression has been detected in several cancer forms. ...

Susann Reinbothe, Anna-Maria Larsson, Marica Vaapil, Caroline Wigerup, Jianmin Sun, Annika Jögi, Drorit Neumann, Lars Rönnstrand, Sven Påhlman (2014) Biochemical and biophysical research communications 445: 1 163-169

Tumour hypoxia and the hypoxia inducible transcription factors, key players in in cancer progression and metastasis.

2014-07-10T09:30:44Z

Annika Jögi (2014) Tumor Cell Metabolism – Pathways, Regulation and Biology

Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells

2013-02-28T10:00:58Z

Abstract INTRODUCTION: Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. Less is known about effects of hypoxia on non-malignant cells. Here we address ...

Marica Vaapil, Karolina Helczynska, Rene Villadsen, Ole William Petersen, Elisabet Johansson, Siv Beckman, Christer Larsson, Sven Påhlman, Annika Jögi (2012) PLoS ONE 7: 9 e46543

Cancer cell differentiation heterogeneity and aggressive behavior in solid tumors.

2012-04-11T20:30:44Z

Abstract The differentiation stage of tumors is a central aspect in the histopathological classification of solid malignancies. The differentiation stage is strongly associated with tumor behavior, and generally an immature tumor is more aggressive than the more differentiated counterpart. While this is common knowledge in surgical pathology, the contribution of differentiation-related gene expres...

Annika Jögi, Marica Vaapil, Martin Johansson, Sven Påhlman (2012) Ups J Med Sci :

Protein kinase Cα suppresses the expression of STC1 in MDA-MB-231 breast cancer cells.

2011-11-15T16:13:18Z

Several protein kinase C (PKC) isoforms have been shown to influence different cellular processes that may contribute to the malignancy of breast cancer cells. To obtain insight into mechanisms mediating the PKC effects, global gene expression was analyzed in MDA-MB-231 breast cancer cells in which PKCα, PKCδ or PKCε had been down-regulated with siRNA. Gene set enrichment analyses revealed that...

Louise Cornmark, Gry Kalstad Lønne, Annika Jögi, Christer Larsson (2011) Tumour Biol 32: 5 1023-1030

Neuroblastoma: Role of hypoxia and hypoxia inducible factors in tumor progression

2011-11-15T16:15:55Z

E Fredlund, A Pietras, A Jögi, S Påhlman (2011) Tumors of the central nervous system

Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice.

2011-01-12T08:30:22Z

BACKGROUND: Proteolytic degradation by plasmin and metalloproteinases is essential for epidermal regeneration in skin wound healing. Plasminogen deficient mice have severely delayed wound closure as have mice simultaneously lacking the two plasminogen activators, urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA). In contrast, individual genetic deficiencies in ...

Jögi A, Rønø B, Lund IK, Nielsen BS, Ploug M, Høyer-Hansen G, Rømer J, Lund LR. (2010) PLoS One 5: 9 e12746

Nuclear expression of the RNA-binding protein RBM3 is associated with an improved clinical outcome in breast cancer.

2010-08-17T08:03:16Z

Single-strand RNA-binding proteins (RBPs) are involved in many aspects of RNA metabolism and in the regulation of gene transcription. The RBP RBM3 was recently suggested to be a proto-oncogene in colorectal cancer; however, such a role has not been corroborated by previous studies in the colon or other tumor types, and the prognostic implications of tumor-specific RBM3 expression remain unclear. M...

Annika Jögi, Donal J Brennan, Lisa Rydén, Kristina Magnusson, Mårten Fernö, Olle Stål, Signe Borgquist, Mathias Uhlen, Göran Landberg, Sven Påhlman, Fredrik Pontén, Karin Jirström (2009) Mod Pathol 22: 12 1564-1574

Antibody-mediated targeting of the urokinase-type plasminogen activator proteolytic function neutralizes fibrinolysis in vivo.

2010-08-17T08:03:16Z

Urokinase-type plasminogen activator (uPA) plays a central role in tissue remodeling processes. Most of our understanding of the role of uPA in vivo is derived from studies using gene-targeted uPA-deficient mice. To enable in vivo studies on the specific interference with uPA functionality in mouse models, we have now developed murine monoclonal antibodies (mAbs) directed against murine uPA by imm...

Ida K Lund, Annika Jögi, Birgitte Rønø, Morten G Rasch, Leif R Lund, Kasper Almholt, Henrik Gårdsvoll, Niels Behrendt, John Rømer, Gunilla Høyer-Hansen (2008) J Biol Chem 283: 47 32506-32515

Prognostic impact of tumour-specific HMG-CoA reductase expression in primary breast cancer.

2010-08-17T08:03:16Z

INTRODUCTION: We have previously reported that tumour-specific expression of the rate-limiting enzyme, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR), in the mevalonate pathway is associated with more favourable tumour parameters in breast cancer. In the present study, we examined the prognostic value of HMG-CoAR expression in a large cohort of primary breast cancer patients with long...

Signe Borgquist, Annika Jögi, Fredrik Pontén, Lisa Rydén, Donal J Brennan, Karin Jirström (2008) Breast Cancer Res 10: 5

Murine monoclonal antibodies against murine uPA receptor produced in gene-deficient mice: inhibitory effects on receptor-mediated uPA activity in vitro and in vivo.

2010-08-17T08:03:16Z

Binding of urokinase plasminogen activator (uPA) to its cellular receptor, uPAR, potentiates plasminogen activation and localizes it to the cell surface. Focal plasminogen activation is involved in both normal and pathological tissue remodeling processes including cancer invasion. The interaction between uPA and uPAR therefore represents a potential target for anti-invasive cancer therapy. Inhibit...

Jesper Pass, Annika Jögi, Ida K Lund, Birgitte Rønø, Morten G Rasch, Henrik Gårdsvoll, Leif R Lund, Michael Ploug, John Rømer, Keld Danø, Gunilla Høyer-Hansen (2007) Thromb Haemost 97: 6 1013-1022

Systemic administration of anti-urokinase plasminogen activator receptor monoclonal antibodies induces hepatic fibrin deposition in tissue-type plasminogen activator deficient mice.

2010-08-17T08:03:16Z

BACKGROUND: Degradation of extracellular matrix proteins, such as fibrin, is pivotal to tumor invasion. Inhibition of the interaction between urokinase plasminogen activator (u-PA) and its receptor (u-PAR), and hence pro-u-PA activation, is an attractive approach to anti-invasive cancer therapy. A number of inhibitors exist for the human system, but because of species specificity none of these are...

A Jögi, J Pass, G Høyer-Hansen, L R Lund, B S Nielsen, K Danø, J Rømer (2007) J Thromb Haemost 5: 9 1936-1944

HIF-2alpha expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia.

2010-08-17T08:03:16Z

Solid tumors are frequently necrotic and hypoxic due to poor vascularization. Tumor cells adapt to hypoxia by modulating their phenotype. Key players in this process are the hypoxia-inducible factors (HIF-1alpha to 3alpha). HIFs are also expressed during normal development; for example, HIF-2alpha is specifically expressed and appears to be involved in the development of the murine sympathetic ner...

Helén Nilsson, Annika Jögi, Siv Beckman, Adrian L Harris, Lorenz Poellinger, Sven Påhlman (2005) Exp Cell Res 303: 2 447-456

Phenotypic persistence after reoxygenation of hypoxic neuroblastoma cells.

2010-08-17T08:03:16Z

Fast-growing solid tumors are usually insufficiently vascularized, leading to areas with necrosis and/or poorly oxygenated cells. Tumor cells adapt to acute hypoxic stress. Central to this adaptation are the hypoxia-inducible transcription factors (HIFs), which are degraded at normoxic but become stabilized at hypoxic conditions. Hypoxic (1% O2) neuroblastoma cells downregulate sympathetic nervous...

Linda Holmquist, Annika Jögi, Sven Påhlman (2005) Int J Cancer 116: 2 218-225

Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells.

2010-08-17T08:03:16Z

ID (inhibitor of differentiation/DNA binding) proteins, frequently deregulated in advanced human malignancies, can participate in multiple fundamental traits of cancer, such as block of differentiation, increased proliferation, tissue invasiveness, and angiogenesis. We have previously demonstrated that hypoxia decreases expression of neuronal marker genes in neuroblastoma, but induces genes expres...

Tobias Löfstedt, Annika Jögi, Mikael Sigvardsson, Katarina Gradin, Lorenz Poellinger, Sven Påhlman, Håkan Axelson (2004) J Biol Chem 279: 38 39223-39231

Human neuroblastoma cells exposed to hypoxia: induction of genes associated with growth, survival, and aggressive behavior.

2010-08-17T08:03:16Z

We have recently found that cells derived from human neuroblastoma, a sympathetic nervous system (SNS) tumor, dedifferentiate and acquire a neural crest-like phenotype when exposed to hypoxia. In the present study, global analysis of gene expression and quantitative PCR of relevant genes showed that hypoxia provokes a general adaptive response in neuroblastoma cells and confirm loss of the neurona...

Annika Jögi, Johan Vallon-Christersson, Linda Holmquist, Håkan Axelson, Ake Borg, Sven Påhlman (2004) Exp Cell Res 295: 2 469-487

Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ.

2010-08-17T08:02:26Z

In cultured neuroblastoma cells, hypoxia induces a dedifferentiated phenotype. We tested whether hypoxia-induced dedifferentiation also occurs in vivo in mammary ductal carcinoma in situ with its well-defined lesions and distinct areas of necrosis. Ductal carcinoma in situ cells surrounding the central necrosis have high hypoxia inducible factor-1alpha protein levels, down-regulated estrogen recep...

Karolina Helczynska, Asa Kronblad, Annika Jögi, Elise Nilsson, Siv Beckman, Göran Landberg, Sven Påhlman (2003) Cancer Res 63: 7 1441-1444

Hypoxia-induced dedifferentiation in neuroblastoma cells.

2010-08-17T08:02:26Z

Hypoxia in solid tumors is associated with aggressive behavior and poor outcome. We recently discovered that hypoxia alters the expression of differentiation marker genes in neuroblastoma cells, in that the tumor cells adjust to the hypoxic environment by down-regulating genes associated with a neuronal and upregulating genes associated with a neural crest-like phenotype. As there is a correlation...

Annika Jögi, Ingrid Øra, Helen Nilsson, Lorenz Poellinger, Håkan Axelson, Sven Påhlman (2003) Cancer Lett 197: 1-2 145-150

Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype.

2010-08-17T08:02:26Z

Insufficient oxygen and nutrient supply often restrain solid tumor growth, and the hypoxia-inducible factors (HIF) 1 alpha and HIF-2 alpha are key transcription regulators of phenotypic adaptation to low oxygen levels. Moreover, mouse gene disruption studies have implicated HIF-2 alpha in embryonic regulation of tyrosine hydroxylase, a hallmark gene of the sympathetic nervous system. Neuroblastoma...

Annika Jögi, Ingrid Øra, Helén Nilsson, Asa Lindeheim, Yuichi Makino, Lorenz Poellinger, Håkan Axelson, Sven Påhlman (2002) Proc Natl Acad Sci U S A 99: 10 7021-7026

Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation.

2010-08-17T08:02:26Z

It is assumed that the Id helix-loop-helix (HLH) proteins act by associating with ubiquitously expressed basic HLH (bHLH) transcription factors, such as E47 and E2-2, which prevents these factors from forming functional hetero- or homodimeric DNA binding complexes. Several tissue-specific bHLH proteins, including HASH-1, dHAND, and HES-1, are important for development of the nervous system. Neurob...

Annika Jögi, Paula Persson, Anna Grynfeld, Sven Påhlman, Håkan Axelson (2002) J Biol Chem 277: 11 9118-9126

Patched 2, located in 1p32-34, is not mutated in high stage neuroblastoma tumors.

2010-08-17T08:02:26Z

Neuroblastoma is a childhood malignancy originating from cells of the sympathetic nervous system, exhibiting a marked diversity in outcome, with spontaneous regression at one end of the spectrum and severe disease and death at the other end. Features associated with frequent recurrence, a poor prognosis, and high tumor stage are loss of heterozygosity in the distal region of chromosome 1p and ampl...

A Jögi, F Abel, R M Sjöberg, R Toftgård, P G Zaphiropoulos, S Påhlman, T Martinsson, H Axelson (2000) Int J Oncol 16: 5 943-949

HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex.

2010-08-17T08:02:26Z

The basic helix-loop-helix (bHLH) transcription factor mammalian achaete-scute homolog-1 (MASH-1 in mouse and HASH-1 in human) is essential for proper development of olfactory and most peripheral autonomic neurons, and for the formation of distinct neuronal circuits within the central nervous system. We have previously shown that HASH-1 is expressed in neuroblastoma tumors and cell lines, and in t...

P Persson, A Jögi, A Grynfeld, S Påhlman, H Axelson (2000) Biochem Biophys Res Commun 274: 1 22-31