http://publicationslist.org/data/ashish.baldi/atom.xml Ashish Baldihttp://publicationslist.org/ashish.baldi$basepathfavicon.icoRecent additions to Ashish Baldi's PublicationsList.org pagehttp://publicationslist.org/publications.png2010-02-06T12:16:26Z http://publicationslist.org/ashish.baldi/refid11 2010-02-06T11:01:44Z

To investigate the plant growth-promoting effect and stimulation of lignan biosynthesis, the effect of culture filtrates/live co-culture of two arbuscular mycorrhizae-like fungi, Piriformospora indica and Sebacina vermifera, on growth of Linum album cells and on production of podophyllotoxin (PT) and 6-methoxypodophyllotoxin (6-MPT) was studied. For elicitation studies, different volumes of cultur...<br/><br/>Ashish Baldi, Sunita Farkya, Abhishek Jain, Nishant Gupta, Rahul Mehra, Vatsala Datta, Ashok Kumar Srivastava and Virendra Swarup Bisaria (2010) <i>Pure and Applied Chemistry</i> 82: 1 227-241<br/>

http://publicationslist.org/ashish.baldi/refid6 2010-02-06T10:26:50Z

The process of drug discovery is very complex and requires an interdisciplinary effort to design effective and commercially feasible drugs. The objective of drug design is to find a chemical compound that can fit to a specific cavity on a protein target both geometrically and chemically. After passing the animal tests and human clinical trials, this compound becomes a drug available to patient...<br/><br/>A Baldi (2010) <i>Systematic Reviews in Pharmacy</i> 1: 1 99<br/>

http://publicationslist.org/ashish.baldi/refid9 2010-02-06T10:53:49Z

Withania somnifera (Solanaceae), commonly known as ashwagandha, is known to have antiinflammatory, antitumor, anticonvulsive and immunosuppressive properties. In the present study, antioxidant potential of in vitro cultured cells and roots of W. somnifera was evaluated within the concentration range of 5-100 μg/ml using in vitro studies viz. free radical scavenging capacity on 1, 1-diphen...<br/><br/>Ashish Baldi, Wazid Hussain, Yogendra Tailor (2010) <i>Current Trends in Biotechnology and Pharmacy</i> 4: 1 589<br/>

http://publicationslist.org/ashish.baldi/refid8 2010-02-06T10:42:49Z

Pharmacogenomics is derived from integration of genomics, medical, pharmacological and biotechnological principles to develop ideal, safe, efficacious drugs with personalized approach based on the genetic variations that exist in all human beings. It plays an important role in design and discovery of “future pharmaceuticals” through understanding of newer and specific target identification, be...<br/><br/>A. Baldi, Y. Tailor (2009) <i>Journal of Global Pharma Technology</i> 1: 1 26<br/>

http://publicationslist.org/ashish.baldi/refid12 2010-02-06T11:14:01Z

Biotechnological production of plant-based secondary metabolites by a cell culture-based bioprocess generally suffers from an inherent disadvantage of low yield. In order to overcome this, elicitation is one of the most promising yield-enhancement strategies. Biotic elicitors, especially those of a fungal origin, are known to increase the production of secondary metabolites in plant cell suspensio...<br/><br/>A. Baldi, A. K. Srivastava, V. S. Bisaria (2009) <i>Soil Biology: Symbiotic Fungi Principles and Practice; Vol. 18</i> 373-380<br/>

http://publicationslist.org/ashish.baldi/refid13 2010-02-06T11:18:04Z

Inability of arbuscular mycorrhizal fungi to grow in pure cultures without living host roots is one of the most challenging hurdles to studying their symbiotic relationship with plants and their effect on cell growth and secondary metabolite production. In this regard, Piriformospora indica, an arbuscular mycorrhiza-like fungus, can be used as a very promising tool, due to its phytopromotional eff...<br/><br/>A. Baldi, A. Jain, N. Gupta, A. K. Srivastava, V. S. Bisaria (2009) <i>Soil Biology: Symbiotic Fungi Principles and Practice; Vol. 18</i> 361-372<br/>

http://publicationslist.org/ashish.baldi/refid20 2010-02-06T11:49:23Z

Erectile dysfunction or impotence is emerging as one of the mostserious life style and stress related disease. Over exertion, physiologicaldisturbances, lowered level of hormones and strained relationship with partner arethe main causes for this disease. Apart from drug therapy and diet control regime,Ayurveda offers natural drugs with proven efficacy for treatment of erectiledysfunction. Ancient ...<br/><br/>A. Baldi (2009) <i>Journal of Research and Education in Indian Medicine</i> XIV: 15-24<br/>

http://publicationslist.org/ashish.baldi/refid4 2010-02-06T10:02:28Z

Cell suspension cultures of Linum album were developed from internode portions of in vitro germinated plant in Gamborg's B5 medium supplemented with 0.4 mg naphthalene acetic acid/l. The highest biomass was 8.5 g/l with podophyllotoxin and 6-methoxypodophyllotoxin at 29 and 1.9 mg/l, respectively after 12 d cultivation. Co-cultures of L. album cells with axenically cultivable arbuscular mycorrhiza...<br/><br/>Ashish Baldi, Abhishek Jain, Nishant Gupta, A K Srivastava, V S Bisaria (2008) <i>Biotechnol Lett</i> <i></i> <i></i> 30: 9 1671-1677<br/>

http://publicationslist.org/ashish.baldi/refid5 2010-02-06T10:16:30Z

Artemisinin, isolated from the shrub-Artemisia annua, is a sesquiterpene lactone used to treat multi-drug resistant strains of falciparum malaria. It is also effective against a wide variety of cancers such as leukemia and colon cancer. To counter the present low content in leaves and uneconomical chemical synthesis, alternate ways to produce artemisinin have been sought. But this compound remains...<br/><br/>Ashish Baldi, V K Dixit (2008) <i>Bioresour Technol</i> 99: 11 4609-4614<br/>

http://publicationslist.org/ashish.baldi/refid24 2010-02-06T12:11:25Z

V.S. Bisaria, A. Baldi, V. Kumar, N. Gupta, A. Jain, S. Farkya, A.K. Srivastava (2008) <i>Journal of Biotechnology</i> 136S: S11<br/>

http://publicationslist.org/ashish.baldi/refid14 2010-02-06T11:20:52Z

A Baldi (2008) <br/>

http://publicationslist.org/ashish.baldi/refid1 2010-02-06T10:02:28Z

Various cell and hairy root cultures of L. album were developed and analyzed for podophyllotoxin content. Transformed callus and hairy root cultures developed from infection of stem portions of in vitro-germinated L. album plant with Agrobacterium rhizogenes NCIM 5140 strain were selected on the basis of high podophyllotoxin content and growth. Based on the integration of Ri T(L)-DNA and T(R)-DNA,...<br/><br/>Ashish Baldi, Ashok K Srivastava, Virendra S Bisaria (2008) <i>Biotechnol J</i> <i></i> <i></i> 3: 9-10 1256-1263<br/>

http://publicationslist.org/ashish.baldi/refid2 2010-02-06T10:02:28Z

The effects of aeration within the range of 0.2-0.5 vvm on transformed and high yielding cell cultures of Linum album were investigated in a 5-L stirred tank bioreactor equipped with low shear Setric impeller. The kinetics of cell growth, substrate utilization, and production of lignans, namely, podophyllotoxin and 6-methoxypodophyllotoxin, were established. Maximum biomass of 23.2 g/L and lignan ...<br/><br/>Ashish Baldi, Ashok K Srivastava, Virendra S Bisaria (2008) <i>Appl Biochem Biotechnol</i> <i></i> <i></i> 151: 2-3 547-555<br/>

http://publicationslist.org/ashish.baldi/refid3 2010-02-06T10:02:28Z

High yielding transformed callus culture of W. somnifera was established by infecting hypocotyls with Agrobacterium tumefaciens MTCC-2250. Maximum withaferin A content of 0.0875 mg/g dry cell weight and transformation efficiency of 80% were obtained. Confirmation of transformation was done on the basis of the presence of the ags gene by using polymerase chain reaction. Various abiotic elicitors (a...<br/><br/>A Baldi, D Singh, Vinod K Dixit (2008) <i>Appl Biochem Biotechnol</i> <i></i> <i></i> 151: 2-3 556-564<br/>

http://publicationslist.org/ashish.baldi/refid7 2010-02-06T10:32:47Z

Artemisinin, an endoperoxide containing sesquiterpene lactone from Artemisia annua, has proven very effective in treating drug resistant cases of malaria and cancer. To counter the present low content in leaves and uneconomical chemical synthesis, alternate ways to produce artemisinin have been sought. Inspite of extensive work in this area, artemisinin remains elusive in dedifferentiated ...<br/><br/>A. Baldi, V.K. Dixit (2008) <i>Current Trends in Biotechnology and Pharmacy</i> 2: 2 341<br/>

http://publicationslist.org/ashish.baldi/refid21 2010-02-06T11:58:41Z

Natural products from plants are providing better templates for design of potential chemotherapeutic agents than synthetic drugs. Taxol, podophyllotoxin and camptothecin are some lead molecules, which has proved to be nature’s boon in the treatment of cancer. To meet their ever-increasing demands, biotechnological methods offer an excellent alternative but the economy of such a production is the...<br/><br/>Ashish Baldi, V.S. Bisaria, A.K. Srivastava (2007) <i>Medicinal Plant Biotechnology: From basic research to industrial applications</i> 117-156<br/>

http://publicationslist.org/ashish.baldi/refid17 2010-02-06T11:35:49Z

This invention provides a process for enhanced production of bioactive compound using co-culturing of biological materials complementary to each other and that grow in synergism. Particularly the invention illustrates a high yielding process for podophyllotoxin, comprising inoculating sterile Linum album plant cells into liquid plant cell culture media to generate suspension culture and coculturin...<br/><br/>V.S. Bisaria, A.K. Srivastava, A. Baldi, A. Jain, N. Gupta (2007) <i>1266/DEL/2007 </i><br/>

http://publicationslist.org/ashish.baldi/refid16 2010-02-06T11:29:09Z

A. Baldi (2007) <i>Indian Journal of Science Communication</i> 6: 2 31-33<br/>

http://publicationslist.org/ashish.baldi/refid22 2010-02-06T12:02:32Z

Artemisinin, an endoperoxide containing sesquiterpene lactone from Artemisia annua, has proven very effective in treating drug resistant cases of malaria. Due to limited availability and variation in artemisinin content from plant, use of high yielding in-vitro cultures would prove useful in meeting the demand for this important therapeutics. Inspite of extensive work in this area, artemisinin rem...<br/><br/>Baldi A, Dixit VK (2006) <i>JNPA</i> XXIV: 1 27-38<br/>

http://publicationslist.org/ashish.baldi/refid23 2010-02-06T12:06:13Z

A. Baldi (2006) <i>JNPA</i> XXIV: 1 1-16<br/>

http://publicationslist.org/ashish.baldi/refid18 2010-02-06T11:38:02Z

Baldi A., Pandey R.S., Madan J., (2002) <i>Journal of Science and Pharmacy</i> 3: 2 62-65<br/>

http://publicationslist.org/ashish.baldi/refid15 2010-02-06T11:26:31Z

A Baldi (2002) <br/>

http://publicationslist.org/ashish.baldi/refid19 2010-02-06T11:40:45Z

Baldi A., Saraf S. (2001) <i>The Eastern Pharmacist</i> XLIV: 519 35-38<br/>