http://publicationslist.org/data/bjhjansen/atom.xml Bastiaan Jansenhttp://publicationslist.org/bjhjansen$basepathfavicon.icoRecent additions to Bastiaan Jansen's PublicationsList.org pagehttp://publicationslist.org/publications.png2012-02-21T09:40:40Z http://publicationslist.org/bjhjansen/refid27 2012-02-21T09:40:00Z

Dendritic cells (DCs) are professional antigen presenting cells of the immune system that play a crucial role in initiating immune responses and maintaining self tolerance. Better understanding of the molecular basis of DC immunobiology is required to improve DC-based immunotherapies. We previously described the interaction of transcription factor LUMAN (also known as CREB3 or LZIP) with the DC-sp...<br/><br/>Anna Sanecka, Marleen Ansems, Maaike A van Hout-Kuijer, Maaike W G Looman, Amy C Prosser, Suzanne Welten, Christian Gilissen, Iziah E Sama, Martijn A Huynen, Joris A Veltman, Bastiaan J H Jansen, Dagmar Eleveld-Trancikova, Gosse J Adema (2012) <i>Mol Immunol</i> <i></i> <i></i> 50: 1-2 66-73<br/>

http://publicationslist.org/bjhjansen/refid22 2012-01-10T15:34:53Z

Mesenchymal Stem Cells (MSC) are quiescent and located in several vascular niches where they serve as a stem cell reservoir. When MSC are mobilized into peripheral tissues they are able to differentiate into various mesodermal cell lineages such as osteocytes, chondrocytes, and adipocytes, depending on the local micro-milieu. MSC can be tremendously expanded in vitro. This prompted us to compare t...<br/><br/>L C J van den Berk, B J H Jansen, K G C Siebers-Vermeulen, T Huijsi, H Roelofs, G Kogler, C G Figdor, R Torensma (2011) <i>Tissue Engineering and Regenerative Medicine</i> <i></i> <i><Go to ISI>://000286951500013</i> 8: 1 96-105<br/>

http://publicationslist.org/bjhjansen/refid23 2011-10-27T12:30:47Z

ABSTRACT: BACKGROUND: MicroRNAs (miRNAs) play a fundamental role in the regulation of gene expression by translational repression or target mRNA degradation. Regulatory elements in miRNA promoters are less well studied, but may reveal a link between their expression and a specific cell type. RESULTS: To explore this link in myeloid cells, miRNA expression profiles were generated from monocytes and...<br/><br/>B J H Jansen, I E Sama, D Eleveld-Trancikova, M A van Hout-Kuijer, J H Jansen, M A Huynen, G J Adema (2011) <i>BMC Genomics</i> <i></i> <i>http://www.ncbi.nlm.nih.gov/pubmed/21708028</i> 12: 330<br/>

http://publicationslist.org/bjhjansen/refid26 2011-10-27T12:30:24Z

ABSTRACT:<br/><br/>A Sanecka, M Ansems, A C Prosser, K Danielski, K Warner, M H den Brok, B J H Jansen, D Eleveld-Trancikova, G J Adema (2011) <i>BMC Immunol</i> <i></i> <i></i> 12: 57<br/>

http://publicationslist.org/bjhjansen/refid25 2011-10-27T12:33:28Z

Tumor microenvironments feature immune inhibitory mechanisms that prevent T cells from generating effective antitumor immune responses. Therapeutic interventions aimed at disrupting these inhibitory mechanisms have been shown to enhance antitumor immunity, but they lack direct cytotoxic effects. Here, we investigated the effect of cytotoxic cancer chemotherapeutics on immune inhibitory pathways. W...<br/><br/>W Joost Lesterhuis, Cornelis J A Punt, Stanleyson V Hato, Dagmar Eleveld-Trancikova, Bastiaan J H Jansen, Stefan Nierkens, Gerty Schreibelt, Annemiek de Boer, Carla M L Van Herpen, Johannes H Kaanders, Johan H J M van Krieken, Gosse J Adema, Carl G Figdor, I Jolanda M de Vries (2011) <i>J Clin Invest</i> <i></i> <i></i> 121: 8 3100-3108<br/>

http://publicationslist.org/bjhjansen/refid15 2011-10-27T12:49:53Z

Previously, we demonstrated that several TLRs are expressed on cord blood-derived USSC. Stimulation of USSC with TLR agonists resulted in a marked increase of IL-6 and IL-8 production. Interestingly, TNF was undetectable after TLR stimulation, which appeared to be a result of an inactivated TNF promoter in USSC. Here, we elaborate this study by demonstrating that although USSC do not produce TNF, ...<br/><br/>L C J van den Berk, B J H Jansen, K G C Siebers-Vermeulen, H Roelofs, C G Figdor, G J Adema, R Torensma (2010) <i>J Leukoc Biol</i> 87: 2 283-9<br/>

http://publicationslist.org/bjhjansen/refid17 2011-10-27T12:49:08Z

Dendritic cells (DCs) are professional antigen-presenting cells that provide a link between innate and adaptive immunity. Multiple DC subsets exist and their activation by microorganisms occurs through binding of conserved pathogen-derived structures to so-called pattern recognition receptors (PRRs). In this study we analyzed the expression of PRRs responding to viral RNA in human monocyte-derived...<br/><br/>M Kramer, B M Schulte, D Eleveld-Trancikova, M van Hout-Kuijer, L W J Toonen, J Tel, I J M de Vries, F J M van Kuppeveld, B J H Jansen, G J Adema (2010) <i>J Innate Immun</i> 2: 4 360-70<br/>

http://publicationslist.org/bjhjansen/refid13 2011-10-27T12:50:24Z

Unrestricted somatic stem cells (USSCs) have been recently identified in human umbilical cord blood and have been shown to differentiate into lineages representing all 3 germ layers. To characterize microRNAs that may regulate osteogenic differentiation of USSCs, we carried out expression analysis for 157 microRNAs using quantitative RT-PCR before and after osteogenic induction (t = 0.5, 24, 72, 1...<br/><br/>A Schaap-Oziemlak, R A Raymakers, S M Bergevoet, C Gilissen, B J H Jansen, G J Adema, G Kögler, C le Sage, R Agami, B A van der Reijden, J H Jansen (2010) <i>Stem Cells Dev</i> 19: 6 877-85<br/>

http://publicationslist.org/bjhjansen/refid19 2011-10-27T12:48:40Z

Stem cells are widely studied to enable their use in tissue repair. However, differences in function and differentiation potential exist between distinct stem cell populations. Whether those differences are due to donor variation, cell culture, or intrinsic properties remains elusive. Therefore, we compared 3 cell lines isolated from 3 different niches using the Affymetrix Exon Array platform: the...<br/><br/>B J H Jansen, C Gilissen, H Roelofs, A Schaap-Oziemlak, J A Veltman, R A P Raymakers, J H Jansen, G Kögler, C G Figdor, R Torensma, G J Adema (2010) <i> Stem Cells Dev</i> <i></i> <i></i> 19: 4 481-90<br/>

http://publicationslist.org/bjhjansen/refid20 2011-10-27T12:47:48Z

D Eleveld-Trancikova, A Sanecka, M A van Hout-Kuijer, M G W Looman, I A M Hendriks, B J H Jansen, G J Adema (2010) <i>Mol Immunol</i> <i></i> <i></i> 47: 11-12 1963-73<br/>

http://publicationslist.org/bjhjansen/refid16 2011-10-27T12:46:08Z

Recently, the antagonizing effect on the differentiation of mesenchymal stem cells (MSCs) by toll-like receptor (TLR) ligands, was described. Our study shows that on more primitive cord blood derived MSCs, the expression of TLRs and ligand-induced triggering differs from that of bone marrow derived MSCs. At the RNA level, cord blood MSCs (unrestricted somatic stem cells; USSCs) express low levels ...<br/><br/>L C J van den Berk, B J H Jansen, K G C Siebers-Vermeulen, M G Netea, T Latuhihin, S Bergevoet, R A Raymakers, G Kögler, C G Figdor, G J Adema, R Torensma (2009) <i>J Cell Mol Med</i> <i></i> <i>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20196781 </i> 13: 9B 3415-26<br/>

http://publicationslist.org/bjhjansen/refid11 2011-10-27T12:46:48Z

Dendritic cell-specific transmembrane protein (DC-STAMP) has been first identified as an EST in a cDNA library of human monocyte-derived dendritic cells (DC). DC-STAMP is a multimembrane spanning protein that has been implicated in skewing haematopoietic differentiation of bone marrow cells towards the myeloid lineage, and in cell fusion during osteoclastogenesis and giant cell formation. To gain ...<br/><br/>B J H Jansen, D Eleveld-Trancikova, A Sanecka, M van Hout-Kuijer, I A M Hendriks, M G W Looman, J H Leusen, G J Adema (2009) <i>Mol Immunol</i> 46: 4 505-15<br/>

http://publicationslist.org/bjhjansen/refid10 2011-10-27T12:43:43Z

D Eleveld-Trancikova, R A J Janssen, I A M Hendriks, M G W Looman, V Moulin, B J H Jansen, J H Jansen, C G Figdor, G J Adema (2008) <i>Leukemia</i> 22: 2 455-9<br/>

http://publicationslist.org/bjhjansen/refid9 2011-11-17T15:46:37Z

The demand for large-scale gene expression analysis tools is on the rise now that several genomes have been sequenced. One of these tools, serial analysis of gene expression (SAGE), allows the qualitative as well as quantitative analysis of a large number of genes in a defined tissue or culture model. SAGE has already been successfully used to identify differentially expressed genes in normal phys...<br/><br/>B J H Jansen, G J de Jongh, J Schalkwijk, F van Ruissen (2005) <i>Methods Mol Biol</i> <i>Epidermal Cells</i> 289: 383-98<br/>

http://publicationslist.org/bjhjansen/refid8 2011-10-27T12:42:52Z

P M Steijlen, M A M van Steensel, B J H Jansen, W Blokx, P C M van de Kerkhof, R Happle, M van Geel (2004) <i>J Invest Dermatol</i> 122: 5 1321-4<br/>

http://publicationslist.org/bjhjansen/refid6 2011-10-27T12:42:26Z

The epidermis protects the organism against physical, chemical and biological challenges, and it acts as a signalling interface between the environment and the body. In order to perform these functions, the epidermal keratinocytes express a wide range of genes, several of which have been characterised previously. Recently, significant progress has been made in the large-scale analysis of keratinoc...<br/><br/>B J H Jansen, J Schalkwijk (2003) <i>Brief Funct Genomic Proteomic</i> 1: 4 326-41<br/>

http://publicationslist.org/bjhjansen/refid7 2011-10-27T12:34:36Z

Using serial analysis of gene expression we have previously identified the expression of several pro-apoptotic and anti-apoptotic genes in cultured human primary epidermal keratinocytes, including tumor necrosis factor related apoptosis inducing ligand (TRAIL). TRAIL is a potent inducer of apoptosis in transformed and tumor cell lines, but usually not in other cells. Here we present a study on the...<br/><br/>B J H Jansen, F van Ruissen, S Cerneus, W Cloin, M Bergers, P E J van Erp, J Schalkwijk (2003) <i>J Invest Dermatol</i> 121: 6 1433-9<br/>

http://publicationslist.org/bjhjansen/refid4 2011-10-27T12:35:21Z

Serial analysis of gene expression (SAGE) has been used for quantitative analysis of gene expression. We applied cluster analysis on multiple SAGE libraries derived from premalignant epidermal tissue (actinic keratosis), normal human epidermis, and cultured keratinocytes. The samples were obtained from skin biopsies without contamination by dermal tissue or blood. A total of 60,000 transcripts (ta...<br/><br/>F van Ruissen, B J H Jansen, G J de Jongh, I M J J van Vlijmen-Willems, J Schalkwijk (2002) <i>Faseb J</i> 16: 2 246-8<br/>

http://publicationslist.org/bjhjansen/refid5 2011-10-27T12:36:04Z

Serial analysis of gene expression (SAGE) is a powerful technique for global expression profiling without prior knowledge of the genes of interest. We carried out SAGE analysis of purified keratinocytes derived from human skin biopsy specimens, resulting in a partial transcriptome of human epidermis. We identified 7645 unique SAGE tags with quantitative information from 15,131 collected SAGE tags ...<br/><br/>F van Ruissen, B J H Jansen, G J de Jongh, P L J M Zeeuwen, J Schalkwijk (2002) <i>Genomics</i> 79: 5 671-8<br/>

http://publicationslist.org/bjhjansen/refid2 2011-10-27T12:38:49Z

Keratinocyte gene expression was surveyed more comprehensively than before, by means of serial analysis of gene expression. A total of 25,694 tags derived from expressed mRNA, were analyzed in a model for normal differentiation and in a model where cultured keratinocytes were stimulated for a prolonged period of time with tumor necrosis factor-alpha, thus mimicking aberrant differentiation in the ...<br/><br/>B J H Jansen, F van Ruissen, G J de Jongh, P L J M Zeeuwen, J Schalkwijk (2001) <i>J Invest Dermatol</i> 116: 1 12-22<br/>

http://publicationslist.org/bjhjansen/refid3 2011-10-27T12:40:03Z

Using serial analysis of gene expression on cultured human keratinocytes we found high expression levels of genes putatively involved in host protection and defense, such as proteinase inhibitors and antimicrobial proteins. One of these expressed genes was the recently discovered cysteine proteinase inhibitor cystatin M/E that has not been characterized so far at the protein level with respect to ...<br/><br/>P L J M Zeeuwen, I M J J van Vlijmen-Willems, B J H Jansen, G Sotiropoulou, J H Curfs, J F G M Meis, J J M Janssen, F van Ruissen, J Schalkwijk (2001) <i>J Invest Dermatol</i> 116: 5 693-701<br/>

http://publicationslist.org/bjhjansen/refid1 2011-11-25T14:24:48Z

The nucleotide sequence of a 1200 bp DNA fragment of Spodoptera exigua nucleopolyhedrovirus (SeMNPV) was determined. This sequence contained a cluster of two open reding frames (ORFs), one coding for a viral ubiquitin (v-ubi) and another with homology to orf2 of Autographa californica (Ac) MNPV and Orgyia pseudotsugata (Op) MNPV. The vubi ORF is 240 nucleotides (nt) long, potentially encoding a pr...<br/><br/>E A van Strien, B J H Jansen, R M W Mans, D Zuidema, J M Vlak (1996) <i>J Gen Virol</i> 77 ( Pt 9): 2311-9<br/>