Brock Tice's Publications List

Image-based models of cardiac structure with applications in arrhythmia and defibrillation studies

2009-04-23T19:12:49Z

The objective of this article is to present a set of methods for constructing realistic computational models of cardiac structure from high-resolution structural and diffusion tensor magnetic resonance images and to demonstrate the applicability of the models in simulation studies. The structural image is segmented to identify various regions such as normal myocardium, ventricles, and infarct. A f...

F Vadakkumpadan, L J Rantner, B Tice, P Boyle, A J Prassl, E Vigmond, G Plank, N Trayanova (2009) J Electrocardiol 42: 2 1-10

Mechanistic investigation into the arrhythmogenic role of transmural heterogeneities in regional ischaemia phase 1A.

2008-02-12T21:11:21Z

AIMS: Studies of arrhythmogenesis during ischemia have focused primarily on reentrant mechanisms manifested on the epicardial surface. The goal of this study was to use a physiologically-accurate model of acute regional ischemia phase 1A to determine the contribution of ischaemia-induced transmural electrophysiological heterogeneities to arrhythmogenesis following left anterior descending artery o...

Brock M Tice, Blanca Rodríguez, James Eason, Natalia Trayanova (2007) Europace 9 Suppl 6: vi46-vi58

Vulnerability to electric shocks in the regionally-ischemic ventricles

2007-09-29T21:18:12Z

B Rodriguez, B Tice, R Blake, D Gavaghan, N Trayanova (2006) Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE 2280-2283

P4-24 : Vulnerability to electric shocks in regional ischemia

2007-09-29T21:18:43Z

Blanca Rodriguez, Brock Tice, Robert C Blake III, James Eason, David Gavaghan, Natalia A Trayanova (2006) Heart Rhythm 3: 5, Supplement 1

Arrthythmogenicity of transmural heterogeneities in a realistic model of regional ischemia

2007-09-29T21:19:01Z

Brock M Tice, Blanca Rodriguez, Natalia A Trayanova (2005) Heart Rhythm 2: 5, Supplement 1

Cardiac vulnerability to electric shocks during phase 1A of acute global ischemia.

2007-10-03T15:43:32Z

OBJECTIVES: The purpose of this study is to characterize the changes in vulnerability to electric shocks during phase 1A of global ischemia in the rabbit ventricles and to determine the mechanisms responsible for these changes. BACKGROUND: Mechanisms responsible for the changes in cardiac vulnerability over the course of ischemia phase 1A remain poorly understood. The lack of understanding results...

Blanca Rodríguez, Brock M Tice, James C Eason, Felipe Aguel, Natalia Trayanova (2004) Heart Rhythm 1: 6 695-703

Effect of acute global ischemia on the upper limit of vulnerability: a simulation study.

2007-09-29T21:12:47Z

The goal of this modeling research is to provide mechanistic insight into the effect of altered membrane kinetics associated with 5-12 min of acute global ischemia on the upper limit of cardiac vulnerability (ULV) to electric shocks. We simulate electrical activity in a finite-element bidomain model of a 4-mm-thick slice through the canine ventricles that incorporates realistic geometry and fiber ...

Blanca Rodríguez, Brock M Tice, James C Eason, Felipe Aguel, José M Ferrero, Natalia Trayanova (2004) Am J Physiol Heart Circ Physiol 286: 6 H2078-H2088

Effect of acute global ischemia on cardiac vulnerability to electrical shocks

2007-09-29T21:18:28Z

B Rodriguez, J C Eason, B Tice, J M , Jr. Ferrero, N Trayanova (2003) Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE 151-154 Vol.1