http://publicationslist.org/data/carine.nizard/atom.xml carine nizardhttp://publicationslist.org/carine.nizard$basepathfavicon.icoRecent additions to carine nizard's PublicationsList.org pagehttp://publicationslist.org/publications.png2015-03-18T16:16:20Z http://publicationslist.org/carine.nizard/refid67 2014-08-12T09:55:59Z

Radjei S, Friguet B, Nizard C, Petropoulos I. (2014) <i>Biochem Soc Trans. </i> 42: 2 518-22<br/>

http://publicationslist.org/carine.nizard/refid68 2015-03-18T16:04:46Z

Repeated exposure to mild heat shock (HS) has been shown to induce a wide range of health promoting hormetic effects in various biological systems, including human cells undergoing aging in vitro. In order to understand how cells distinguish between mild and severe stress, we have investigated the extent of early and immediate HS response by analyzing the nuclear translocation of the transcription...<br/><br/>Dino Demirovic, Irene Martinez de Toda, Carine Nizard, Suresh I S Rattan (2014) <i>Journal of cell communication and signaling</i> <i></i> <i></i> 8: 4 333-339<br/>

http://publicationslist.org/carine.nizard/refid66 2013-10-18T07:25:10Z

Human cysteine cathepsin S (catS) participates in distinct physiological and pathophysiological cellular processes and is considered as a valuable therapeutic target in autoimmune diseases, cancer, atherosclerosis, and asthma. We evaluated the capacity of negatively charged glycosaminoglycans (heparin, heparan sulfate, chondroitin 4/6-sulfates, dermatan sulfate, and hyaluronic acid) to modulate th...<br/><br/>Juliette Sage, Florian Mallèvre, Fabien Barbarin-Costes, Sergey A Samsonov, Jan-Philip Gehrcke, Maria Teresa Pisabarro, Eric Perrier, Sylvianne Schnebert, André Roget, Thierry Livache, Carine Nizard, Gilles Lalmanach, Fabien Lecaille (2013) <i>Biochemistry</i> <i></i> <i></i> 52: 37 6487-6498<br/>

http://publicationslist.org/carine.nizard/refid61 2013-08-19T15:23:08Z

Application of hormesis in aging research and interventions is becoming increasingly attractive and successful. The reason for this is the realization that mild stress-induced activation of one or more stress response (SR) pathways, and its consequent stimulation of repair mechanisms, is effective in reducing the age-related accumulation of molecular damage. For example, repeated heat stress-induc...<br/><br/>Suresh I S Rattan, Valérie Kryzch, Sylvianne Schnebert, Eric Perrier, Carine Nizard (2013) <i>Dose-response : a publication of International Hormesis Society</i> <i></i> <i></i> 11: 1 99-108<br/>

http://publicationslist.org/carine.nizard/refid62 2013-08-19T15:23:14Z

Cutaneous aging translates drastic structural and functional alterations in the extracellular matrix (ECM). Multiple mechanisms are involved, including changes in protease levels. We investigated the age-related protein expression and activity of cysteine cathepsins and the expression of two endogenous protein inhibitors in young and aged Caucasian women skin epidermis. Immunofluorescence studies ...<br/><br/>Juliette Sage, Delphine De Quéral, Emmanuelle Leblanc-Noblesse, Robin Kurfurst, Sylvianne Schnebert, Eric Perrier, Carine Nizard, Gilles Lalmanach, Fabien Lecaille (2013) <i>Matrix biology : journal of the International Society for Matrix Biology</i> <i></i> <i></i> : <br/>

http://publicationslist.org/carine.nizard/refid59 2013-08-19T15:23:20Z

Skin acts as a barrier between the environment and internal organs and performs functions that are critical for the preservation of body homeostasis. In mammals, a complex network of circadian clocks and oscillators adapts physiology and behavior to environmental changes by generating circadian rhythms. These rhythms are induced in the central pacemaker and peripheral tissues by similar transcript...<br/><br/>Cristina Sandu, Marc Dumas, André Malan, Diariétou Sambakhe, Clarisse Marteau, Carine Nizard, Sylvianne Schnebert, Eric Perrier, Etienne Challet, Paul Pévet, Marie-Paule Felder-Schmittbuhl (2012) <i>Cellular and molecular life sciences : CMLS</i> <i></i> <i></i> 69: 19 3329-3339<br/>

http://publicationslist.org/carine.nizard/refid60 2013-08-19T15:08:30Z

Cathepsin S (catS), which is expressed in normal human keratinocytes and localized close to the dermal-epidermal junction (DEJ) degrades some of major basement membrane (BM) constituents. Among them, catS readily hydrolyzed in a time and dose dependent manner human nidogen-1 (nid-1) and nidogen-2, which are key proteins in the BM structure. CatS preferentially cleaved nid-1 at both acid and neutra...<br/><br/>Juliette Sage, Emmanuelle Leblanc-Noblesse, Carine Nizard, Takako Sasaki, Sylvianne Schnebert, Eric Perrier, Robin Kurfurst, Dieter Brömme, Gilles Lalmanach, Fabien Lecaille (2012) <i>PloS one</i> <i></i> <i></i> 7: 8 <br/>

http://publicationslist.org/carine.nizard/refid58 2013-08-19T15:19:24Z

Transfer of the melanocyte-specific and lysosome-related organelle, the melanosome, from melanocytes to keratinocytes is crucial for the protection of the skin against harmful ultraviolet radiation (UVR)--our main physiological cutaneous stressor. However, this commonplace event remains a most enigmatic process despite several early hypotheses. Recently, we and others have proposed a role for filo...<br/><br/>Suman K Singh, Robin Kurfurst, Carine Nizard, Sylvianne Schnebert, Eric Perrier, Desmond J Tobin (2010) <i>FASEB journal : official publication of the Federation of American Societies for Experimental Biology</i> <i></i> <i></i> 24: 10 3756-3769<br/>

http://publicationslist.org/carine.nizard/refid55 2013-08-19T15:19:24Z

Melanosomes are melanocyte-specific lysosome-related organelles that are transferred to keratinocytes of the epidermis and anagen hair bulb. Transferred melanin forms supra-nuclear caps that protect epidermal keratinocytes against UV irradiation. The mechanism(s) responsible for melanosome transfer into keratinocytes and their subsequent intra-keratinocyte distribution has long remained one of the...<br/><br/>Suman K Singh, Carine Nizard, Robin Kurfurst, Frederic Bonte, Sylvianne Schnebert, Desmond J Tobin (2008) <i>Experimental dermatology</i> <i></i> <i></i> 17: 5 418-426<br/>

http://publicationslist.org/carine.nizard/refid19 2008-01-16T13:51:26Z

Issa Tapsoba , Marielle Moreau , Catherine Heusele , Nadège Lachmann-Weber , Christian Amatore ,Sylvianne Schnebert , Carine Nizard , Stéphane Arbault . (2007) <i>Congrès Cosminnov, Orléans Octobre 2007</i> <br/>

http://publicationslist.org/carine.nizard/refid21 2008-01-16T13:52:51Z

Anne-Laure Bulteau, Marielle Moreau, Slahedine Zidi, Monique Gareil, Cécile Lamy, Robin Kurfurst, Carine Nizard and Bertrand Friguet (2007) <i>Proteolyse Seillac Mars 2007</i> <br/>

http://publicationslist.org/carine.nizard/refid20 2008-01-16T13:50:45Z

Anne-Laure Bulteau, Marielle Moreau, Slahedine Zidi, Monique Gareil, Cécile Lamy, Robin Kurfurst, Carine Nizard and Bertrand Friguet (2007) <i>Congrès Nutrition et antioxydants Paris Avril 2007</i> <br/>

http://publicationslist.org/carine.nizard/refid4 2013-08-19T15:19:23Z

During chronic UV irradiation, which is part of the skin aging process, proteins are damaged by reactive oxygen species resulting in the accumulation of oxidatively modified protein. UV irradiation generates irreversible oxidation of the side chains of certain amino acids resulting in the formation of carbonyl groups on proteins. Nevertheless, certain amino acid oxidation products such as methioni...<br/><br/>Cédric R Picot, Marielle Moreau, Mylène Juan, Emmanuelle Noblesse, Carine Nizard, Isabelle Petropoulos, Bertrand Friguet (2007) <i>Experimental gerontology</i> <i></i> <i></i> 42: 9 859-863<br/>

http://publicationslist.org/carine.nizard/refid2 2008-01-16T13:24:38Z

BACKGROUND AND OBJECTIVES: Skin without significant dyschromia is an aesthetic goal of people worldwide. Current options for lightening skin could have significant drawbacks. The antisense strategy may be a viable alternative. The reactions in melanogenesis are catalyzed mainly by tyrosinase, tyrosinase-related protein 1 (TRP-1), and TRP-2. Activation of tyrosinase is associated with phosphorylati...<br/><br/>Kristell Lazou, Neil S Sadick, Robin Kurfurst, Mathilde Bonnet-Duquennoy, Michèle Neveu, Carine Nizard, Catherine Heusele, Sylvianne Schnebert, Eric Perrier (2007) <i>J Drugs Dermatol</i> <i></i> <i></i> 6: 6 Suppl s2-s7<br/>

http://publicationslist.org/carine.nizard/refid1 2008-01-16T13:24:38Z

BACKGROUND AND OBJECTIVES: Cell longevity is linked to sirtuins (silent information regulators), which belong to a family of enzymes implicated in gene silencing, apoptosis, fatty acid metabolism, and regulation of cellular life spans of organisms. Sirtuins are associated with genes that coordinate and optimize the functions of cells as cells struggle to survive in a stressful environment, as it i...<br/><br/>Marielle Moreau, Michèle Neveu, Sandrine Stéphan, Emmanuelle Noblesse, Carine Nizard, Neil S Sadick, Sylvianne Schnebert, Frédéric Bonté, Marc Dumas, Patrice Andre, Eric Perrier (2007) <i>J Drugs Dermatol</i> <i></i> <i></i> 6: 6 Suppl s14-s19<br/>

http://publicationslist.org/carine.nizard/refid3 2008-01-16T13:24:38Z

Cellular aging is characterized by the accumulation of oxidatively modified proteins that result, at least in part, from impaired degradation of abnormal proteins. The proteasome is the major intracellular proteolytic system implicated in the removal of abnormal and oxidized proteins. In human epidermal cells, previous studies have evidenced that proteasome function is decreased during aging as we...<br/><br/>Anne-Laure Bulteau, Marielle Moreau, Carine Nizard, Bertrand Friguet (2007) <i>Ann N Y Acad Sci</i> <i></i> <i></i> 1100: 280-290<br/>

http://publicationslist.org/carine.nizard/refid57 2008-06-02T11:13:32Z

(2007) <i></i><br/>

http://publicationslist.org/carine.nizard/refid23 2008-01-17T09:13:16Z

Issa TAPSOBA , Marielle MOREAU , Catherine HEUSELE , Nadège LACHMANN-WEBER , Christian AMATORE , Carine NIZARD , Stéphane ARBAULT (2006) <i>ESDR 2006</i> <br/>

http://publicationslist.org/carine.nizard/refid5 2008-01-16T13:24:38Z

Senile lentigo is a common component of photoaged skin. It is characterized by hyperpigmented macules which affect chronically irradiated skin mostly after the age of 50. This study was undertaken to assess the morphology of senile lentigo on the dorsum of the hands. A systematic comparison between lesional and perilesional skin using histology and transmission electron microscopy was done to dete...<br/><br/>E Noblesse, C Nizard, M Cario-André, S Lepreux, C Pain, S Schnebert, A Taïeb, R Kurfurst (2006) <i>Skin Pharmacol Physiol</i> <i></i> <i></i> 19: 2 95-100<br/>

http://publicationslist.org/carine.nizard/refid6 2008-01-16T13:24:38Z

Sun exposure is the major environmental influence for epidermal cells; the harmful effect of UV radiation on skin is related to the generation of reactive oxygen species that alter cellular components including proteins. It is now well established that the proteasome is responsible for the degradation of most of oxidized proteins and that impairment of proteasome function is a hallmark of cellular...<br/><br/>Anne-Laure Bulteau, Marielle Moreau, Alex Saunois, Carine Nizard, Bertrand Friguet (2006) <i>Antioxid Redox Signal</i> <i></i> <i></i> 8: 1-2 136-143<br/>

http://publicationslist.org/carine.nizard/refid28 2008-01-16T14:15:56Z

O. Duverger, M. Moreau, S. Schnebert, C. Nizard (2005) <i>ASCB 45th Annual Meeting Dec 10-14, 2005, San Francisco, CA</i> <br/>

http://publicationslist.org/carine.nizard/refid27 2008-01-16T14:14:55Z

O. Duverger, M. Moreau, M. Bonnet-Duquennoy, S. Schnebert, C. Nizard (2005) <i>ASCB 45th Annual Meeting Dec 10-14, 2005, San Francisco, CA</i> <br/>

http://publicationslist.org/carine.nizard/refid29 2008-01-16T14:17:41Z

C. Nizard, M. Cario-André, S. Lepreux, C. Pain, E. Noblesse, S. Schnebert, C. Mahé, A. Taïeb. (2005) <i>International Journal of Cosmetic Science, Vol. 27, n° 1, Fev. 2005</i> : <br/>

http://publicationslist.org/carine.nizard/refid26 2008-01-16T14:12:26Z

Anne Laure Bulteau, Marielle Moreau, Alex Saunois, Carine Nizard, Bertrand Friguet (2005) <i>Quatrième colloque « Proteolyse cellulaire de la SFBBM », 12-14 décembre 2005, Aussois.</i> <br/>

http://publicationslist.org/carine.nizard/refid30 2008-01-16T14:18:58Z

E. Noblesse, C. Nizard, M. Cario-André, S. Lepreux, C. Pain, S. Schnebert, A. Taïeb, R. Kurfurst (2005) <i>32nd Annual Meeting of the SCUR June 1-4th, 2005 HAMBURG</i> <br/>

http://publicationslist.org/carine.nizard/refid31 2008-01-17T09:40:57Z

C. Marteau, E. Noblesse, S.Talbourdet , C.Duquesne, C. Nizard, M. Cario-André, A.Taïeb, R.Kurfurst and S.Schnebert (2005) <i>35th Annual Meeting of the European Society for Dermatological Research (ESDR) in Tübingen, Germany, 22-24 September 2005.</i> <br/>

http://publicationslist.org/carine.nizard/refid7 2008-01-16T13:24:38Z

Proteins are modified by reactive oxygen species, and oxidation of specific amino acid residues can impair their biological functions, leading to an alteration in cellular homeostasis. Oxidized proteins can be eliminated through either degradation or repair. Repair is limited to the reversion of a few modifications such as the reduction of methionine oxidation by the methionine sulfoxide reductase...<br/><br/>Cédric R Picot, Isabelle Petropoulos, Martine Perichon, Marielle Moreau, Carine Nizard, Bertrand Friguet (2005) <i>Free Radic Biol Med</i> <i></i> <i></i> 39: 10 1332-1341<br/>

http://publicationslist.org/carine.nizard/refid25 2008-01-16T14:10:07Z

CR. Picot, I. Petropoulos, M. Perichon, M. Moreau, C. Nizard and B. Friguet (2005) <i>Congres of the Society for Free Radical Research-Europe. 2005, Leicester, Angleterre</i> <br/>

http://publicationslist.org/carine.nizard/refid24 2008-01-16T14:07:55Z

CR. Picot, I. Petropoulos, M. Perichon, C. Nizard and B. Friguet. (2005) <i>Free Radical School 2004, Spetses, Grèce</i> <br/>

http://publicationslist.org/carine.nizard/refid32 2008-01-17T14:43:30Z

Proteins are modified by reactive oxygen species and oxidation of specific aminoacid residues can impair their biological functions leading to an alteration of cellular homeostasis. Oxidized proteins can be rapidly eliminated through either degradation or repair. Degradation of oxidized proteins is achieved by the proteasome, a multicatalytic proteolytic system, while repair is limited to few modi...<br/><br/>Cedric Picot ,Carine Nizard, Isabelle Petropoulos, Martine Perichon, Sylvianne Schnebert, Bertrand Friguet. (2004) <i>Journal of Investigative Dermatology. 2004 Vol. 122 n° 3 pA30 SID Providence Avril </i> <br/>

http://publicationslist.org/carine.nizard/refid8 2008-01-16T13:24:38Z

Heat shock protein (HSP) 47 is a specific chaperone of procollagen. This heat shock protein is responsible for the correct three-dimensional organization of procollagen and its control-quality prior secretion. The aim of the study is to evaluate the level of HSP 47 in aged, photoaged, and senescent fibroblasts and its modulation by a plant extract (Salix alba). The level of HSP 47 and/or procollag...<br/><br/>Carine Nizard, Emmanuelle Noblesse, Cécille Boisdé, Marielle Moreau, Anne-Marie Faussat, Sylvianne Schnebert, Christian Mahé (2004) <i>Ann N Y Acad Sci</i> <i></i> <i></i> 1019: 223-227<br/>

http://publicationslist.org/carine.nizard/refid10 2008-01-16T13:24:38Z

BACKGROUND: Senile lentigo (SL) is a common component of photoaged skin. It is characterized by hyperpigmented macules which affect chronically irradiated skin mostly after 50 years of age. This study was undertaken to assess the basic morphology of SL on dorsum of hands. METHODS: A systematic comparison between lesional vs. perilesional skin using immunohistochemistry and electron microscopy was ...<br/><br/>Muriel Cario-Andre, Sebastien Lepreux, Catherine Pain, Carine Nizard, Emmanuelle Noblesse, Alain Taïeb (2004) <i>J Cutan Pathol</i> <i></i> <i></i> 31: 6 441-447<br/>

http://publicationslist.org/carine.nizard/refid9 2008-01-16T13:24:38Z

Modification of proteins by reactive oxygen species is implicated in different disorders. The proteasome is a multicatalytic proteinase in charge of intracellular protein turnover and of oxidized proteins degradation. Consequently, proteasome function is very important in controlling the level of altered proteins in eukaryotic cells. Evidence for a decline in proteasome activity during skin photo-...<br/><br/>Carine Nizard, Sylvie Poggioli, Catherine Heusèle, Anne-Laure Bulteau, Marielle Moreau, Alex Saunois, Sylvianne Schnebert, Christian Mahé, Bertrand Friguet (2004) <i>Ann N Y Acad Sci</i> <i></i> <i></i> 1019: 219-222<br/>

http://publicationslist.org/carine.nizard/refid36 2008-01-16T14:37:41Z

Muriel Cario-André, ., Sébastien Lepreux, ., Catherine Pain, Carine Nizard, Emmanuelle Noblesse , Sylvianne Schnebert, Christian Mahé, Alain Taïeb (2004) <i>Journal of Investigative Dermatology. 2004 Vol. 122 n° 3 pA42</i> <br/>

http://publicationslist.org/carine.nizard/refid33 2008-01-16T14:31:33Z

CR. Picot, I. Petropoulos, M. Perichon, C. Nizard and B. Friguet. (2004) <i>Free Radical School 2004, Spetses, Grèce</i> <br/>

http://publicationslist.org/carine.nizard/refid38 2008-01-16T14:40:27Z

R. Kurfurst, K. Lazou, M. Bonnet-Duquennoy, L. Decup, C. Nizard, S. Schnebert, C. Mahé (2004) <i>Pigment Cell Research Vol. 17 n° 5 Oct. 2004, p 595</i> <br/>

http://publicationslist.org/carine.nizard/refid37 2008-01-16T14:39:16Z

Carine Nizard, Muriel Cario-André, ., Sébastien Lepreux, ., Catherine Pain, Emmanuelle Noblesse , Sylvianne Schnebert, Christian Mahé, Alain Taïeb (2004) <i>Pigment Cell Research Vol. 17 n° 5 Oct. 2004, p 592</i> <br/>

http://publicationslist.org/carine.nizard/refid34 2008-01-16T14:34:12Z

I. Petropoulos , CR. Picot, M. Perichon, C. Nizard and B. Friguet. (2004) <i>4th European Congress of biogerontology 2004, Newcastle. </i> <br/>

http://publicationslist.org/carine.nizard/refid35 2008-01-16T14:35:47Z

C Nizard, S.Poggioli, C. Heusele, AL Bulteau, M Moreau, C. Mahe, S Schnebert, B Friguet (2004) <i>Journal of Investigative Dermatology. 2004 Vol. 122 n° 3 pA41</i> <br/>

http://publicationslist.org/carine.nizard/refid42 2008-01-17T14:30:42Z

Proteins are modified by reactive oxygen species and oxidation of specific aminoacid residues can impair their biological functions leading to an alteration of cellular homeostasis. Oxidized proteins can be rapidly eliminated through either degradation or repair. Degradation of oxidized proteins is achieved by the proteasome, a multicatalytic proteolytic system, while repair is limited to fe...<br/><br/>Cedric Picot, Isabelle Petropoulos, Martine Perichon, Sylvianne Schnebert, Christian Mahé, Carine Nizard, and Bertrand Friguet (2003) <i>SFFRBM ,Vol 35, suppl 1, 2003, poster 342, pS109 Society for Free Radical Biology & Medecine 21-24 Nov 2003 Seatlle USA</i> <br/>

http://publicationslist.org/carine.nizard/refid13 2008-01-16T13:25:37Z

Ultraviolet A (UVA) (320-400 nm) radiation is known to cause cutaneous aging and skin cancer. We studied the effect of UVA (365 nm) radiation on the human epidermis by focusing on keratinocyte gap junction-mediated intercellular communication (GJIC). We observed a dose-dependent 10-fold decrease in GJIC induced by UVA in normal human keratinocytes. This decrease in GJIC was associated with time-de...<br/><br/>Nicolas Provost, Marielle Moreau, Armelle Leturque, Carine Nizard (2003) <i>Am J Physiol Cell Physiol</i> <i></i> <i></i> 284: 1 C51-C59<br/>

http://publicationslist.org/carine.nizard/refid41 2008-01-17T14:32:09Z

HSP 47 is a specific chaperone of pro-collagen. This heat shock protein is responsible for the correct 3-dimentional organization of pro-collagen and its control-quality prior secretion. The aim of the study is to evaluate the level of HSP47 in aged, photoaged and senescent fibroblasts and its modulation by a plant extract (Salix Alba). We measured the level of HSP47 and/or pro-collagen expressi...<br/><br/>C. Nizard, M. Moreau, E. Noblesse, A.M. Faussat, S. Schnebert. (2003) <i>Journal of Investigative Dermatology 2003, vol 121, n°1 ref: 1155 SID Miami Florida</i> <br/>

http://publicationslist.org/carine.nizard/refid40 2008-01-17T14:25:07Z

Modification of proteins by reactive oxygen species is implicated in different disorders. The proteasome is a multicatalytic proteinase in charge of intracellular protein turnover and of oxidized proteins degradation. Consequently, proteasome function is very important in controlling the level of altered proteins in eukaryotic cells. Evidence for a decline in proteasome activity during skin photo-...<br/><br/>Carine Nizard, Sylvie Poggioli , Catherine Heusèle, Anne-Laure Bulteau, Marielle Moreau, Alex Saunois, Sylvianne Schnebert, Christian Mahé and Bertrand Friguet. (2003) <i> Biogerontology 2003, Volume 4, supplement 1, p73 . The International Association of Biomedical Gerontology 19-23 Sept Cambridge UK</i> <br/>

http://publicationslist.org/carine.nizard/refid39 2008-01-17T14:23:30Z

HSP 47 is a specific chaperone of pro-collagen. This heat shock protein is responsible for the correct 3-dimentional organization of pro-collagen and its control-quality prior secretion. The aim of the study is to evaluate the level of HSP47 in aged, photoaged and senescent fibroblasts and its modulation by a plant extract (Salix Alba). We measured the level of HSP47 and/or pro-collagen expressi...<br/><br/> E. Noblesse, C. Boisdé, M. Moreau, A.M. Faussat, S. Schnebert, C.Mahé, and C. Nizard. (2003) <i>Biogerontology 2003, Volume 4, supplement 1, p73. The International Association of Biomedical Gerontology 19-23 Sept Cambridge UK</i> <br/>

http://publicationslist.org/carine.nizard/refid51 2008-01-17T14:01:12Z

L’influence environnementale majeure pour les cellules de l’épiderme est l’exposition au soleil et l’effet nocif de l’irradiation UV sur la peau est lié à la production d’espèces réactives de l’oxygène qui vont altérer tous les composants cellulaires notamment les protéines. Il est maintenant bien établi que le protéasome est responsable de la dégradation des protéines ox...<br/><br/>Friguet B, Bulteau AL , Moreau M , Nizard C (2002) <i>Symposium « Protéolyse cellulaire » de la Société Française de Biochimie et Biologie Moléculaire (SFBBM) 25-27 mars 2002 Montpellier</i> <br/>

http://publicationslist.org/carine.nizard/refid52 2008-01-17T14:06:12Z

The proteasome is a multicatalytic proteinase in charge of intracellular protein turnover and of oxidized proteins degradation. Consequently, proteasome function is very important in controlling the level of altered proteins in eukaryotic cells. Evidence for a decline in proteasome activity during aging and upon oxidative stress has been provided previously. However, no data are available on the s...<br/><br/>C Nizard, AL Bulteau, M Moreau,, A Saunois, B Friguet. (2002) <i>JID :Journal of Investigative Dermatology ; 2002 Vol 119 (1) p333SID ; Los Angeles, USA, 14 -18 Mai 2002 </i> <br/>

http://publicationslist.org/carine.nizard/refid54 2008-01-17T13:59:29Z

The major environmental influence for skin cells is sun exposure, and the combined effect of aging and sun damage has been referred as to photoaging. Photoaging induces morphological changes such as wrinkling and sagging due to general alteration of all the epidermal and dermal components of the skin including the cutaneous cells (Bisset et al., 1992). The harmful effect of UV radiation on skin is...<br/><br/>Bertrand Friguet, Anne-Laure Bulteau,, Marielle Moreau and Carine Nizard. (2002) <i> Wrinkle symposium, 15 Octobre 2002, Paris</i> <br/>

http://publicationslist.org/carine.nizard/refid53 2008-01-17T13:52:21Z

It is well established that the proteasome is responsible for the degradation of oxidized proteins. The effects of UV irradiation on proteasome has been investigated in human keratinocytes cultures. The effects of an apolar algae extract (Pht) on proteasome were performed. Human keratinocytes were irradiated by 10 J/cm2 of UVA and 0.05 J/cm2 of UVB. Proteasome peptidase activities and levels o...<br/><br/>Carine Nizard , Anne-Laure Bulteau, Marielle Moreau, Alex saunois et Bertrand Friguet (2002) <i>Congrès mondial de dermatologie, Juillet 2002</i> <br/>

http://publicationslist.org/carine.nizard/refid11 2008-01-16T13:25:37Z

Carine Nizard, Anne-Laure Bulteau, Marielle Moreau, Alex Saunois, Bertrand Friguet (2002) <i>Eur J Dermatol</i> <i></i> <i></i> 12: 6 XXVII-XXVIII<br/>

http://publicationslist.org/carine.nizard/refid14 2008-01-17T14:03:23Z

The major environmental influence for epidermal cells is sun exposure and the harmful effect of UV radiation on skin is related to the generation of reactive oxygen species that are altering cellular components including proteins. It is now well established that the proteasome is responsible for the degradation of oxidized proteins. Therefore, the effects of UV-irradiation on proteasome have been ...<br/><br/>Anne-Laure Bulteau, Marielle Moreau, Carine Nizard, Bertrand Friguet (2002) <i>Free Radic Biol Med</i> 32: 11 1157-1170<br/>

http://publicationslist.org/carine.nizard/refid12 2008-01-16T13:25:37Z

Bertrand Friguet, Anne-Laure Bulteau, Marielle Moreau, Carine Nizard (2002) <i>Eur J Dermatol</i> <i></i> <i></i> 12: 6 XVII-XVIII<br/>

http://publicationslist.org/carine.nizard/refid43 2008-01-17T13:24:31Z

Cellular aging is associated with the accumulation of modified macromolecules. The major environmental influence for epidermal cells is sun exposure, and the combined effect of aging and sun damage has been referred as photo-aging. The harmful effect of UV radiation on skin is related to the generation of reactive oxygen species that are altering cellular components including proteins. It is now w...<br/><br/>L. Bulteau, M. Moreau, C. Nizard and B. Friguet (2001) <i>Proteasome workshop, Clermont-Ferrand , 04/07 avril 2001</i> <br/>

http://publicationslist.org/carine.nizard/refid46 2008-01-17T13:29:57Z

Cellular aging is associated with the accumulation of modified macromolecules. The major environmental influence for epidermal cells is sun exposure, and the combined effect of aging and sun damage has been referred as photo-aging. The harmful effect of UV radiation on skin is related to the generation of reactive oxygen species that are altering cellular components including proteins. It is now w...<br/><br/>Bulteau, A. L. ; Moreau, M. ; Nizard, C.; Friguet, B. (2001) <i>Protein Biology : from synthesis to function and disease. EMBO lecture, 4-14 sept 2001, Grèce. </i> <br/>

http://publicationslist.org/carine.nizard/refid44 2008-01-17T13:27:37Z

Cellular aging is associated with the accumulation of modified macromolecules. The major environmental influence for epidermal cells is sun exposure, and the combined effect of aging and sun damage has been referred as photo-aging. The harmful effect of UV radiation on skin is related to the generation of reactive oxygen species that are altering cellular components including proteins. It is now w...<br/><br/>Bulteau, A. L. ; Moreau, M. ; Nizard, C.; Friguet, B. (2001) <i>European Journal of Biochemistry , vol 268, p122, 2001 FEBS Meeting, Lisbonne, Portugal , 30/6-5/7 2001 </i> <br/>

http://publicationslist.org/carine.nizard/refid50 2008-01-17T13:31:26Z

Skin aging is a multifactorial phenomenon involving programmed aging and oxidative stress which are linked to the darkening of skin tone and the appearance of fine lines and then wrinkles. The epidermis plays a central role in the skin and is mainly composed of keratinocytes. Keratinocyte communication plays an important part in maintaining epidermal homeostasis and functionality. Gap junctions ...<br/><br/>Frédéric Bonté, Carine Nizard, Nicolas Provost, Marc Dumas and Sylviane Schnebert (2001) <i>IFSCC, Taipeh, Taiwan, 17-19 Septembre 2001</i> <br/>

http://publicationslist.org/carine.nizard/refid45 2008-01-17T13:28:08Z

The proteasome is a multicatalytic proteinase in charge of intracellular protein turnover and of oxidized proteins degradation. Consequently, proteasome function is very important in controlling the level of altered proteins in eukaryotic cells. Evidence for a decline in proteasome activity during aging and upon oxidative stress has been provided previously. However, no data are available on the s...<br/><br/>Nizard, C.; Bulteau, A. L.; Moreau, M. ; Saunois, A. ; Friguet, B. (2001) <i> European Journal of Biochemistry , vol 268, p122, 2001. FEBS Meeting, Lisbonne, Portugal , 30/6-5/7 2001</i> <br/>

http://publicationslist.org/carine.nizard/refid63 2013-08-19T15:23:45Z

Initiated/selected (ISH) and normal (NH) rat hepatocytes were used to study cytoskeleton modifications induced by three liver acting chemicals: 2-AAF, a liver complete carcinogen; PB, a liver tumor promoter; and 4-AAF, a non-carcinogen analogue of 2-AAF. Cytoskeleton alterations were visualized by disappearance of F-actin fibers and tubulin depolymerization. The three drugs induced actin fragmenta...<br/><br/>C Nizard, M Martin, F Decloitre (1993) <i>Cell biology and toxicology</i> <i></i> <i></i> 9: 1 61-76<br/>

http://publicationslist.org/carine.nizard/refid64 2013-08-19T15:23:28Z

The induction of primary DNA damage by the non-carcinogen 4-AAF was reinvestigated in liver cells by comparison with the carcinogen 2-AAF. DNA alkaline elution showed the appearance of single-strand breaks in total liver DNA of rats 4 h after gavage with 200 mg/kg of 4-AAF. The decrease in hepatocyte viability and yield observed in these livers after collagenase perfusion indicated a cytotoxic eff...<br/><br/>C Nizard, F Decloître (1990) <i>Mutation research</i> <i></i> <i></i> 244: 3 245-250<br/>

http://publicationslist.org/carine.nizard/refid65 2013-08-19T15:23:36Z

Non transformed epithelial hepatic cells (established cell line and adult rat hepatocytes) treated by liver tumor promoters, phenobarbital and biliverdin, for 24 and 48 h showed a fragmentation and loss of F-actin and a depolymerisation of microtubules. This pattern closely resembles that of transformed cells which were not susceptible to the action of promoters. In liver preneoplastic nodules obt...<br/><br/>F Decloître, M Martin, M Ouldelhkim, C Nizard (1990) <i>Bulletin du cancer</i> <i></i> <i></i> 77: 5 479-483<br/>

http://publicationslist.org/carine.nizard/refid56 2008-06-02T11:05:52Z

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