http://publicationslist.org/data/christoph.harms/atom.xml Christoph Harmshttp://publicationslist.org/christoph.harms$basepathfavicon.icoRecent additions to Christoph Harms's PublicationsList.org pagehttp://publicationslist.org/publications.png2009-09-21T19:24:53Z http://publicationslist.org/christoph.harms/refid3 2009-09-21T19:20:53Z

Acetylation/deactylation of histones is an important mechanism to regulate gene expression and chromatin remodeling. We have previously demonstrated that the HDAC inhibitor trichostatin A (TSA) protects cortical neurons from oxygen/glucose deprivation in vitro which is mediated--at least in part--via the up regulation of gelsolin expression. Here, we demonstrate that TSA treatment dose-dependently...<br/><br/>Ferah Yildirim, Karen Gertz, Golo Kronenberg, Christoph Harms, Klaus B Fink, Andreas Meisel, Matthias Endres (2008) <i>Exp Neurol</i> <i></i> <i></i> 210: 2 531-542<br/>

http://publicationslist.org/christoph.harms/refid2 2009-09-21T19:20:53Z

Folate deficiency and resultant increased homocysteine levels have been linked experimentally and epidemiologically with neurodegenerative conditions like stroke and dementia. Moreover, folate deficiency has been implicated in the pathogenesis of psychiatric disorders, most notably depression. We hypothesized that the pathogenic mechanisms include uracil misincorporation and, therefore, analyzed t...<br/><br/>Golo Kronenberg, Christoph Harms, Robert W Sobol, Fernando Cardozo-Pelaez, Heinz Linhart, Benjamin Winter, Mustafa Balkaya, Karen Gertz, Shanna B Gay, David Cox, Sarah Eckart, Michael Ahmadi, Georg Juckel, Gerd Kempermann, Rainer Hellweg, Reinhard Sohr, Heide Hörtnagl, Samuel H Wilson, Rudolf Jaenisch, Matthias Endres (2008) <i>J Neurosci</i> <i></i> <i></i> 28: 28 7219-7230<br/>

http://publicationslist.org/christoph.harms/refid1 2009-09-21T19:20:53Z

BACKGROUND AND PURPOSE: Brain inflammation is a hallmark of stroke, where it has been implicated in tissue damage as well as in repair. Imaging technologies that specifically visualize these processes are highly desirable. In this study, we explored whether the inflammatory receptor CD40 can be noninvasively and specifically visualized in mice after cerebral ischemia using a fluorescent monoclonal...<br/><br/>Jan Klohs, Michael Gräfe, Kristof Graf, Jens Steinbrink, Thore Dietrich, Dietger Stibenz, Peyman Bahmani, Golo Kronenberg, Christoph Harms, Matthias Endres, Ute Lindauer, Klaus Greger, Ernst H K Stelzer, Ulrich Dirnagl, Andreas Wunder (2008) <i>Stroke</i> <i></i> <i></i> 39: 10 2845-2852<br/>

http://publicationslist.org/christoph.harms/refid21 2009-09-21T19:22:52Z

p27(Kip1) (p27) blocks cell proliferation through the inhibition of cyclin-dependent kinase-2 (Cdk2). Despite its robust expression in the heart, little is known about both the function and regulation of p27 in this and other nonproliferative tissues, in which the expression of its main target, cyclin E-Cdk2, is known to be very low. Here we show that angiotensin II, a major cardiac growth factor,...<br/><br/>Ludger Hauck, Christoph Harms, Junfeng An, Jens Rohne, Karen Gertz, Rainer Dietz, Matthias Endres, Rüdiger von Harsdorf (2008) <i>Nat Med</i> <i></i> <i></i> 14: 3 315-324<br/>

http://publicationslist.org/christoph.harms/refid22 2009-09-21T19:22:52Z

Statins are widely used clinical drugs that exert beneficial growth-suppressive effects in patients with cardiac hypertrophy. We investigated the role of the cell cycle inhibitor p21(CIP1/WAF1) (p21) in statin-dependent inhibition of hypertrophic growth in postmitotic cardiomyocytes. We demonstrate that lovastatin fails to inhibit cardiac hypertrophy to angiotensin II in p21(-/-) mice and that rec...<br/><br/>Ludger Hauck, Christoph Harms, Daniela Grothe, Junfeng An, Karen Gertz, Golo Kronenberg, Rainer Dietz, Matthias Endres, Rüdiger von Harsdorf (2007) <i>Circ Res</i> <i></i> <i></i> 100: 1 50-60<br/>

http://publicationslist.org/christoph.harms/refid5 2009-09-21T19:22:52Z

The role of glucocorticoids in the regulation of apoptosis remains incongruous. Here, we demonstrate that corticosterone protects neurons from apoptosis by a mechanism involving the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). In primary cortical neurons, corticosterone leads to a dose- and Akt-kinase-dependent upregulation with enhanced phosphorylation and cytoplasmic appearance of p21(Waf1/...<br/><br/>Christoph Harms, Katharina Albrecht, Ulrike Harms, Kerstin Seidel, Ludger Hauck, Tina Baldinger, Denise Hübner, Golo Kronenberg, Junfeng An, Karsten Ruscher, Andreas Meisel, Ulrich Dirnagl, Rüdiger von Harsdorf, Matthias Endres, Heide Hörtnagl (2007) <i>J Neurosci</i> <i></i> <i></i> 27: 17 4562-4571<br/>

http://publicationslist.org/christoph.harms/refid4 2009-09-21T19:20:53Z

Serum insulin-like growth factor I (IGF-I), which is mostly produced by the liver, has recently been shown to have the unexpected ability to modulate normal brain function as well as brain response to injury. Moreover, serum IGF-I levels are modified in many brain diseases, including stroke. However, whether these modifications are related to the disease process remains uncertain. We now examined ...<br/><br/>Matthias Endres, Joaquin Piriz, Karen Gertz, Christoph Harms, Andreas Meisel, Golo Kronenberg, Ignacio Torres-Aleman (2007) <i>Brain Res</i> <i></i> <i></i> 1185: 328-335<br/>

http://publicationslist.org/christoph.harms/refid7 2009-09-21T19:20:53Z

Histone acetylation and deacetylation participate in the epigenetic regulation of gene expression. In this paper, we demonstrate that pre-treatment with the histone deacetylation inhibitor trichostatin A (TSA) enhances histone acetylation in primary cortical neurons and protects against oxygen/glucose deprivation, a model for ischaemic cell death in vitro. The actin-binding protein gelsolin was id...<br/><br/>Andreas Meisel, Christoph Harms, Ferah Yildirim, Julian Bösel, Golo Kronenberg, Ulrike Harms, Klaus B Fink, Matthias Endres (2006) <i>J Neurochem</i> <i></i> <i></i> 98: 4 1019-1031<br/>

http://publicationslist.org/christoph.harms/refid6 2009-09-21T19:20:53Z

Physical activity upregulates endothelial nitric oxide synthase (eNOS), improves endothelium function, and protects from vascular disease. Here, we tested whether voluntary running would enhance neovascularization and long-term recovery following mild brain ischemia. Wild-type mice were exposed to 30 minutes of middle-cerebral artery occlusion (MCAo) and reperfusion. Continuous voluntary running o...<br/><br/>Karen Gertz, Josef Priller, Golo Kronenberg, Klaus B Fink, Benjamin Winter, Helmut Schröck, Shengbo Ji, Milan Milosevic, Christoph Harms, Michael Böhm, Ulrich Dirnagl, Ulrich Laufs, Matthias Endres (2006) <i>Circ Res</i> <i></i> <i></i> 99: 10 1132-1140<br/>

http://publicationslist.org/christoph.harms/refid8 2009-09-21T19:20:53Z

The intermediate filament nestin is upregulated in response to cerebral ischemia; the significance of this, however, is incompletely understood. Here, we used transgenic mice that express green fluorescent protein (GFP) under control of the nestin promotor to characterize the fate of nestin-expressing cells up to 8 weeks after 30 mins occlusion of the middle cerebral artery (MCAo) and reperfusion....<br/><br/>Golo Kronenberg, Li-Ping Wang, Michael Synowitz, Karen Gertz, Juri Katchanov, Rainer Glass, Christoph Harms, Gerd Kempermann, Helmut Kettenmann, Matthias Endres (2005) <i>J Cereb Blood Flow Metab</i> <i></i> <i></i> 25: 12 1613-1624<br/>

http://publicationslist.org/christoph.harms/refid9 2009-09-21T19:20:53Z

Statins [3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors] exert cholesterol-independent pleiotropic effects that include anti-thrombotic, anti-inflammatory, and anti-oxidative properties. Here, we examined direct protective effects of atorvastatin on neurones in different cell damage models in vitro. Primary cortical neurones were pre-treated with atorvastatin and then exposed...<br/><br/>Julian Bösel, Florin Gandor, Christoph Harms, Michael Synowitz, Ulrike Harms, Pierre Chryso Djoufack, Dirk Megow, Ulrich Dirnagl, Heide Hörtnagl, Klaus B Fink, Matthias Endres (2005) <i>J Neurochem</i> <i></i> <i></i> 92: 6 1386-1398<br/>

http://publicationslist.org/christoph.harms/refid10 2009-09-21T19:20:53Z

Uracil-DNA glycosylase (UNG) is involved in base excision repair of aberrant uracil residues in nuclear and mitochondrial DNA. Ung knockout mice generated by gene targeting are viable, fertile, and phenotypically normal and have regular mutation rates. However, when exposed to a nitric oxide donor, Ung(-/-) fibroblasts show an increase in the uracil/cytosine ratio in the genome and augmented cell ...<br/><br/>Matthias Endres, Detlev Biniszkiewicz, Robert W Sobol, Christoph Harms, Michael Ahmadi, Andreas Lipski, Juri Katchanov, Philipp Mergenthaler, Ulrich Dirnagl, Samuel H Wilson, Andreas Meisel, Rudolf Jaenisch (2004) <i>J Clin Invest</i> <i></i> <i></i> 113: 12 1711-1721<br/>

http://publicationslist.org/christoph.harms/refid11 2009-09-21T19:21:48Z

Gelsolin (gsn), an actin-severing protein, protects neurons from excitotoxic cell death via inactivation of membranous Ca(2+) channels. Its role during apoptotic cell death, however, has remained unclear. Using several models of neuronal cell death, we demonstrate that endogenous gelsolin has anti-apoptotic properties that correlate to its dynamic actions on the cytoskeleton. We show that neurons ...<br/><br/>Christoph Harms, Julian Bösel, Marion Lautenschlager, Ulrike Harms, Johann S Braun, Heide Hörtnagl, Ulrich Dirnagl, David J Kwiatkowski, Klaus Fink, Matthias Endres (2004) <i>Mol Cell Neurosci</i> <i></i> <i></i> 25: 1 69-82<br/>

http://publicationslist.org/christoph.harms/refid12 2009-09-21T19:21:48Z

A direct involvement of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO1) in neuroprotection has not yet been shown. The aim of this study was to examine changes, localization and role of NQO1 after different neuronal injury paradigms. In primary cultures of rat cortex the activity of NQO1 was measured after treatment with ethylcholine aziridinium (AF64A; 40 micro m), inducing mainly ap...<br/><br/>Krisztian J Kapinya, Ulrike Harms, Christoph Harms, Katharina Blei, Juri Katchanov, Ulrich Dirnagl, Heide Hörtnagl (2003) <i>J Neurochem</i> <i></i> <i></i> 84: 5 1028-1039<br/>

http://publicationslist.org/christoph.harms/refid13 2009-09-21T19:21:48Z

Since pharmacological interactions of the renin-angiotensin system appear to alter the neurological outcome of stroke patients significantly, we examined the effect of elevated levels of angiotensin II and the role of its receptor subtype AT1 in brain infarction in transgenic mice after focal cerebral ischemia. Angiotensinogen-overexpressing and angiotensin receptor AT1 knockout mice underwent 1 h...<br/><br/>Thomas Walther, Laszlo Olah, Christoph Harms, Bjoern Maul, Michael Bader, Heide Hörtnagl, Heinz-Peter Schultheiss, Günter Mies (2002) <i>FASEB J</i> <i></i> <i></i> 16: 2 169-176<br/>

http://publicationslist.org/christoph.harms/refid15 2009-09-21T19:22:52Z

After mild ischemic insults, many neurons undergo delayed neuronal death. Aberrant activation of the cell cycle machinery is thought to contribute to apoptosis in various conditions including ischemia. We demonstrate that loss of endogenous cyclin-dependent kinase (Cdk) inhibitor p16(INK4a) is an early and reliable indicator of delayed neuronal death in striatal neurons after mild cerebral ischemi...<br/><br/>J Katchanov, C Harms, K Gertz, L Hauck, C Waeber, L Hirt, J Priller, R von Harsdorf, W Bruck, H Hortnagl, U Dirnagl, P G Bhide, M Endres (2001) <i>J Neurosci</i> <i></i> <i></i> 21: 14 5045-5053<br/>

http://publicationslist.org/christoph.harms/refid16 2009-09-21T19:21:48Z

The major goal of this study was to compare mechanisms of the neuroprotective potential of 17 beta-estradiol in two models for oxidative stress-independent apoptotic neuronal cell death with that in necrotic neuronal cell death in primary neuronal cultures derived from rat hippocampus, septum, or cortex. Neuronal apoptosis was induced either by staurosporine or ethylcholine aziridinium (AF64A), as...<br/><br/>C Harms, M Lautenschlager, A Bergk, J Katchanov, D Freyer, K Kapinya, U Herwig, D Megow, U Dirnagl, J R Weber, H Hörtnagl (2001) <i>J Neurosci</i> <i></i> <i></i> 21: 8 2600-2609<br/>

http://publicationslist.org/christoph.harms/refid14 2009-09-21T19:21:48Z

Oxidative injury contributes to cellular damage during and after cerebral ischemia. However, the downstream catabolic pathways of damaged cellular components in neurons are largely unknown. In the current study, the authors examined the formation of oxidized proteins and their active degradation by the proteasome. In near-pure rat primary cortical neurons, it was found that protein-bound carbonyls...<br/><br/>M Weih, M Schmitt, J Gieche, C Harms, K Ruscher, U Dirnagl, T Grune (2001) <i>J Cereb Blood Flow Metab</i> <i></i> <i></i> 21: 9 1090-1096<br/>

http://publicationslist.org/christoph.harms/refid20 2009-09-21T19:21:48Z

The involvement of nitric oxide in neurodegenerative processes still remains incompletely characterized. Although nitric oxide has been reported to be an important mediator in neuronal degeneration in different models of cell death involving NMDA-receptor activation, increasing evidence for protective mechanisms has been obtained. In this study the role of nitric oxide was investigated in a model ...<br/><br/>M Lautenschlager, M V Onufriev, N V Gulyaeva, C Harms, D Freyer, U Sehmsdorf, K Ruscher, Y V Moiseeva, A Arnswald, I Victorov, U Dirnagl, J R Weber, H Hörtnagl (2000) <i>Neuroscience</i> <i></i> <i></i> 97: 2 383-393<br/>

http://publicationslist.org/christoph.harms/refid19 2009-09-21T19:21:48Z

SV129 or C57BL/6 mice were exposed to hyperbaric oxygenation (HBO, 5 days, 1 h every day, 100% O(2) at 3 atm absolute). One day after the 5th HBO session focal cerebral ischemia was induced. In SV129 mice, HBO induced tolerance against permanent focal cerebral ischemia (n=42, mean infarct volume reduction 27%, P=0.001), but not against transient (30 or 60 min) focal cerebral ischemia. In the C57BL...<br/><br/>K Prass, F Wiegand, P Schumann, M Ahrens, K Kapinya, C Harms, W Liao, G Trendelenburg, K Gertz, M A Moskowitz, F Knapp, I V Victorov, D Megow, U Dirnagl (2000) <i>Brain Res</i> <i></i> <i></i> 871: 1 146-150<br/>

http://publicationslist.org/christoph.harms/refid18 2009-09-21T19:21:48Z

To assess the neuroprotective potential of melatonin in apoptotic neuronal cell death, we investigated the efficacy of melatonin in serum-free primary neuronal cultures of rat cortex by using three different models of caspase-dependent apoptotic, excitotoxin-independent neurodegeneration and compared it to that in necrotic neuronal damage. Neuronal apoptosis was induced by either staurosporine or ...<br/><br/>C Harms, M Lautenschlager, A Bergk, D Freyer, M Weih, U Dirnagl, J R Weber, H Hörtnagl (2000) <i>FASEB J</i> <i></i> <i></i> 14: 12 1814-1824<br/>

http://publicationslist.org/christoph.harms/refid17 2009-09-21T19:21:48Z

The development of serotonergic neurons of the rat raphe was followed in primary neuronal cell cultures taken at embryonic days embryonic day 13 and embryonic day 14 from three different raphe sub-groups, topographically defined with respect to their position to the isthmus as rostral (R1), intermediate (R2) and caudal (R3). In neurons cultivated from embryonic day 13 raphe serotonin, immunoreacti...<br/><br/>M Lautenschlager, M Höltje, B von Jagow, R W Veh, C Harms, A Bergk, U Dirnagl, G Ahnert-Hilger, H Hörtnagl (2000) <i>Neuroscience</i> <i></i> <i></i> 99: 3 519-527<br/>