http://publicationslist.org/data/d.lison/atom.xml Dominique Lisonhttp://publicationslist.org/d.lison$basepathfavicon.icoRecent additions to Dominique Lison's PublicationsList.org pagehttp://publicationslist.org/publications.png2010-11-13T08:50:22Z http://publicationslist.org/d.lison/refid9 2010-11-13T08:46:46Z

OBJECTIVE: To conduct a systematic review and meta-analysis of published studies on the association between parental occupational exposure to pesticides and childhood leukaemia. METHODS: Studies were identified from a MEDLINE search through 31 July 2009 and from the reference lists of identified publications. Relative risk (RR) estimates were extracted from 25 studies published between 1985 and 20...<br/><br/>Geneviève Van Maele-Fabry, Anne-Catherine Lantin, Perrine Hoet, Dominique Lison (2010) <i>Cancer Causes Control</i> <i></i> <i></i> 21: 6 787-809<br/>

http://publicationslist.org/d.lison/refid7 2010-11-13T08:46:46Z

Dominique Lison, Monique Delos (2010) <i>Am J Respir Crit Care Med</i> <i></i> <i></i> 182: 4 578; author reply 578-578; author reply 579<br/>

http://publicationslist.org/d.lison/refid10 2010-11-13T08:46:46Z

IL-17-producing T lymphocytes play a crucial role in inflammation, but their possible implication in fibrosis remains to be explored. In this study, we examined the involvement of these cells in a mouse model of lung inflammation and fibrosis induced by silica particles. Upregulation of IL-17A was associated with the development of experimental silicosis, but this response was markedly reduced in ...<br/><br/>Sandra Lo Re, Laure Dumoutier, Isabelle Couillin, Charlotte Van Vyve, Yousof Yakoub, Francine Uwambayinema, Benoît Marien, Sybille van den Brûle, Jacques Van Snick, Catherine Uyttenhove, Bernard Ryffel, Jean-Christophe Renauld, Dominique Lison, François Huaux (2010) <i>J Immunol</i> <i></i> <i></i> 184: 11 6367-6377<br/>

http://publicationslist.org/d.lison/refid11 2010-11-13T08:46:46Z

PURPOSE: To evaluate the effectiveness of personal protective measures in a dismantling plant for chemical weapons from World War I of the Belgian Defence. METHODS: Seventeen NIOSH level B-equipped plant workers exposed to arsenic trichloride (AsCl(3)) in combination with phosgene or hydrogen cyanide (HCN) were compared to 24 NIOSH level C-protected field workers occasionally exposed to genotoxic ...<br/><br/>R A Mateuca, C Carton, M Roelants, S Roesems, D Lison, M Kirsch-Volders (2010) <i>Int Arch Occup Environ Health</i> <i></i> <i></i> 83: 5 483-495<br/>

http://publicationslist.org/d.lison/refid13 2010-11-13T08:46:46Z

For the investigation of the interaction of nanoparticles with biomolecules, cells, organs, and animal models there is a need for well-characterized nanoparticle suspensions. In this paper we report the preparation of monodisperse dense amorphous silica nanoparticles (SNP) suspended in physiological media that are sterile and sufficiently stable against aggregation. SNP sols with various particle ...<br/><br/>Leen C J Thomassen, Alexander Aerts, Virginie Rabolli, Dominique Lison, Laetitia Gonzalez, Micheline Kirsch-Volders, Dorota Napierska, Peter H Hoet, Christine E A Kirschhock, Johan A Martens (2010) <i>Langmuir</i> <i></i> <i></i> 26: 1 328-335<br/>

http://publicationslist.org/d.lison/refid6 2010-11-13T08:46:46Z

Prostaglandin (PG) D(2) exerts contrasting activities in the inflamed lung via two receptors, the D prostanoid receptor (DP) and the chemoattractant receptor-homologous molecule expressed on T helper 2 lymphocytes. DP activation is known mainly to inhibit proinflammatory cell functions. We tested the effect of a DP-specific agonist, (4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidaz...<br/><br/>Sybille van den Brule, Laurent Wallemme, Francine Uwambayinema, François Huaux, Dominique Lison (2010) <i>J Pharmacol Exp Ther</i> <i></i> <i></i> 335: 2 472-479<br/>

http://publicationslist.org/d.lison/refid8 2010-11-13T08:46:46Z

Lung disorders induced by inhaled inorganic particles such as crystalline silica are characterized by chronic inflammation and pulmonary fibrosis. Here, we demonstrate the importance of type I interferon (IFN) in the development of crystalline silica-induced lung inflammation in mice, revealing that viruses and inorganic particles share similar signaling pathways. We found that instillation of sil...<br/><br/>Giulia Giordano, Sybille van den Brûle, Sandra Lo Re, Perrine Triqueneaux, Francine Uwambayinema, Yousof Yakoub, Isabelle Couillin, Bernhard Ryffel, Thomas Michiels, Jean-Christophe Renauld, Dominique Lison, François Huaux (2010) <i>Toxicol Sci</i> <i></i> <i></i> 116: 2 682-692<br/>

http://publicationslist.org/d.lison/refid5 2010-11-13T08:46:46Z

Identifying the physico-chemical characteristics of nanoparticles (NPs) that drive their toxic activity is the key to conducting hazard assessment and guiding the design of safer nanomaterials. Here we used a set of 17 stable suspensions of monodisperse amorphous silica nanoparticles (SNPs) with selected variations in size (diameter, 2-335 nm), surface area (BET, 16-422 m(2)/g) and microporosity (...<br/><br/>Virginie Rabolli, Leen C J Thomassen, Catherine Princen, Dorota Napierska, Laetitia Gonzalez, Micheline Kirsch-Volders, Peter H Hoet, François Huaux, Christine E A Kirschhock, Johan A Martens, Dominique Lison (2010) <i>Nanotoxicology</i> <i></i> <i></i> 4: 3 307-318<br/>

http://publicationslist.org/d.lison/refid1 2010-11-13T08:46:46Z

We explored how to assess the genotoxic potential of nanosize particles with a well validated assay, the in vitro cytochalasin-B micronucleus assay, detecting both clastogens and aneugens. Monodisperse Stöber amorphous silica nanoparticles (SNPs) of three different sizes (16, 60 and 104 nm) and A549 lung carcinoma cells were selected as models. Cellular uptake of silica was monitored by ICP-MS. A...<br/><br/>Laetitia Gonzalez, Leen C J Thomassen, Gina Plas, Virginie Rabolli, Dorota Napierska, Ilse Decordier, Mathieu Roelants, Peter H Hoet, Christine E A Kirschhock, Johan A Martens, Dominique Lison, Micheline Kirsch-Volders (2010) <i>Nanotoxicology</i> <i></i> <i></i> 4: 382-395<br/>

http://publicationslist.org/d.lison/refid3 2010-11-13T08:46:46Z

BACKGROUND: Efavirenz (EFV) is characterized by interindividual pharmacokinetic variability causing inconsistent clinical responses. Previous studies have identified some possible genetic determinants of the variability in plasma concentrations. However, their impact on EFV intracellular pharmacokinetics remains mostly unexplored. AIMS: To confirm previous observations concerning the influence of ...<br/><br/>Laure Elens, Bernard Vandercam, Jean-Cyr Yombi, Dominique Lison, Pierre Wallemacq, Vincent Haufroid (2010) <i>Pharmacogenomics</i> <i></i> <i></i> 11: 9 1223-1234<br/>

http://publicationslist.org/d.lison/refid2 2010-11-13T08:46:46Z

OBJECTIVE: To conduct a systematic review of published studies on the association between residential/household/domestic exposure to pesticides and childhood leukaemia, and to provide a quantitative estimate of the risk. METHODS: Publications in English were searched in MEDLINE (1966-31 December 2009) and from the reference list of identified publications. Extraction of relative risk (RR) estimate...<br/><br/>Geneviève Van Maele-Fabry, Anne-Catherine Lantin, Perrine Hoet, Dominique Lison (2010) <i>Environ Int</i> <i></i> <i></i> : <br/>

http://publicationslist.org/d.lison/refid4 2010-11-13T08:46:46Z

The metabolome is the set of small molecular mass organic compounds found in a given biological media. It includes all organic substances naturally occurring from the metabolism of the studied living organism, except biological polymers, but also xenobiotics and their biotransformation products. The metabolic fingerprints of biofluids obtained by mass spectrometry (MS) or nuclear magnetic resonanc...<br/><br/>Aurélie Roux, Dominique Lison, Christophe Junot, Jean-François Heilier (2010) <i>Clin Biochem</i> <i></i> <i></i> : <br/>

http://publicationslist.org/d.lison/refid18 2010-11-13T08:46:46Z

The effect that monodisperse amorphous spherical silica particles of different sizes have on the viability of endothelial cells (EAHY926 cell line) is investigated. The results indicate that exposure to silica nanoparticles causes cytotoxic damage (as indicated by lactate dehydrogenase (LDH) release) and a decrease in cell survival (as determined by the tetrazolium reduction, MTT, assay) in the EA...<br/><br/>Dorota Napierska, Leen C J Thomassen, Virginie Rabolli, Dominique Lison, Laetitia Gonzalez, Micheline Kirsch-Volders, Johan A Martens, Peter H Hoet (2009) <i>Small</i> <i></i> <i></i> 5: 7 846-853<br/>

http://publicationslist.org/d.lison/refid19 2010-11-13T08:46:46Z

Macrophages phagocyte pathogenic microorganisms and orchestrate immune responses by producing a variety of inflammatory mediators. The cystic fibrosis (CF) transmembrane conductance regulator chloride channel has been reported to be of pivotal importance for macrophage functions. The exact phenotype and role of macrophages in CF is still unknown. Alveolar and peritoneal macrophages were monitored ...<br/><br/>Magali Meyer, François Huaux, Ximena Gavilanes, Sybille van den Brûle, Patrick Lebecque, Sandra Lo Re, Dominique Lison, Bob Scholte, Pierre Wallemacq, Teresinha Leal (2009) <i>Am J Respir Cell Mol Biol</i> <i></i> <i></i> 41: 5 590-602<br/>

http://publicationslist.org/d.lison/refid17 2010-11-13T08:46:46Z

BACKGROUND: Beneficial effects of azithromycin in cystic fibrosis (CF) have been reported, however, its mechanism of action remains unclear. The present study aimed at investigating the effect of azithromycin on CF airway epithelial cells. METHODS: Primary cultures of purified tracheal epithelial cells from F508del and normal homozygous mice were established. Responses to lipopolysaccharide from P...<br/><br/>Ximena Gavilanes, François Huaux, Magali Meyer, Patrick Lebecque, Etienne Marbaix, Dominique Lison, Bob Scholte, Pierre Wallemacq, Teresinha Leal (2009) <i>J Cyst Fibros</i> <i></i> <i></i> 8: 3 203-210<br/>

http://publicationslist.org/d.lison/refid22 2010-11-13T08:46:46Z

PURPOSE: trans,trans-Muconic acid (t,t-MA) is generally considered as a useful biomarker of exposure to benzene. However, because of its lack of specificity, concerns about its value at low level of exposure have recently been raised. The aim of this study was (a) to compare t,t-MA, S-phenylmercapturic acid (SPMA) and benzene (B-U) as urinary biomarkers of exposure to low levels of benzene in petr...<br/><br/>Perrine Hoet, Erika De Smedt, Massimo Ferrari, Marcello Imbriani, Luciano Maestri, Sara Negri, Peter De Wilde, Dominique Lison, Vincent Haufroid (2009) <i>Int Arch Occup Environ Health</i> <i></i> <i></i> 82: 8 985-995<br/>

http://publicationslist.org/d.lison/refid20 2010-11-13T08:46:46Z

BACKGROUND: False-negative responses to specific inhalation challenge (SIC) with occupational agents may occur. We explored whether assessing changes in sputum cell counts would help improve the identification of bronchial reactivity to occupational agents during SICs. METHODS: The predictive value of the changes in sputum cell counts after a negative FEV(1) response to a first challenge exposure ...<br/><br/>O Vandenplas, V D'Alpaos, J Heymans, J Jamart, J Thimpont, F Huaux, D Lison, J-C Renauld (2009) <i>Allergy</i> <i></i> <i></i> 64: 5 754-761<br/>

http://publicationslist.org/d.lison/refid21 2010-11-13T08:46:46Z

Indium-Tin-Oxide (ITO) is a sintered mixture of indium- (In(2)O(3)) and tin-oxide (SnO(2)) in a ratio of 90:10 (wt:wt) that is used for the manufacture of LCD screens and related high technology applications. Interstitial pulmonary diseases have recently been reported in workers from ITO producing plants. The present study was conducted to identify experimentally the exact chemical component respo...<br/><br/>Dominique Lison, Julie Laloy, Ingrid Corazzari, Julie Muller, Virginie Rabolli, Nadtha Panin, François Huaux, Ivana Fenoglio, Bice Fubini (2009) <i>Toxicol Sci</i> <i></i> <i></i> 108: 2 472-481<br/>

http://publicationslist.org/d.lison/refid16 2010-11-13T08:46:46Z

Toxicological investigations of carbon nanotubes have shown that they can induce pulmonary toxicity, and similarities with asbestos fibers have been suggested. We previously reported that multiwall carbon nanotubes (MWCNT) induced lung inflammation, granulomas and fibrotic reactions. The same MWCNT also caused mutations in epithelial cells in vitro and in vivo. These inflammatory and genotoxic act...<br/><br/>Julie Muller, Monique Delos, Nadtha Panin, Virginie Rabolli, François Huaux, Dominique Lison (2009) <i>Toxicol Sci</i> <i></i> <i></i> 110: 2 442-448<br/>

http://publicationslist.org/d.lison/refid14 2010-11-13T08:46:46Z

Serum Clara cell protein (CC16) and surfactant-associated protein D (SP-D) were measured in 161 workers exposed to sulphur dioxide (SO(2)) in a non-ferrous smelter. Seventy workers from a blanket manufacture served as referents. Exposure to SO(2) and tobacco smoking were associated with a decrease of CC16 and an increase of SP-D in serum. Tobacco smoking and exposure SO(2) interacted synergistical...<br/><br/>Nahida Haddam, Sekkal Samira, Xavier Dumont, Abdesselem Taleb, Vincent Haufroid, Dominique Lison, Alfred Bernard (2009) <i>Biomarkers</i> <i></i> <i></i> 14: 5 292-298<br/>

http://publicationslist.org/d.lison/refid12 2010-11-13T08:46:46Z

AIM: Lopinavir (LPV) is a potent protease inhibitor used in combination with low doses of ritonavir in the treatment of HIV-infected patients. LPV pharmacokinetics is characterized by a large interindividual variability requiring the use of therapeutic drug monitoring in different clinical situations. While the sources of this variability are still unknown, several genetic polymorphisms in biotran...<br/><br/>Laure Elens, Jean-Cyr Yombi, Dominique Lison, Pierre Wallemacq, Bernard Vandercam, Vincent Haufroid (2009) <i>Pharmacogenomics</i> <i></i> <i></i> 10: 10 1589-1597<br/>

http://publicationslist.org/d.lison/refid15 2010-11-13T08:46:46Z

This paper reports the validation of a liquid chromatography tandem mass spectrometry (LC-MS/MS) method that allows the quantification of 10 antiretroviral (ARV) drugs in peripheral blood mononuclear cells (PBMCs) using 6 different isotopic internal standards (IS) and its clinical application. PBMCs are isolated from blood by density gradient centrifugation and drugs are extracted with a 60% metha...<br/><br/>L Elens, S Veriter, J C Yombi, V Di Fazio, R Vanbinst, D Lison, P Wallemacq, B Vandercam, V Haufroid (2009) <i>J Chromatogr B Analyt Technol Biomed Life Sci</i> <i></i> <i></i> 877: 20-21 1805-1814<br/>

http://publicationslist.org/d.lison/refid29 2010-11-13T08:46:46Z

PURPOSE: The purpose of this paper is to review available cohort studies and to estimate quantitatively the association between occupational exposure in plants manufacturing pesticides and leukaemia. METHODS: Following a systematic literature search, relative risks were extracted from 14 studies published between 1984 and 2004. Fixed effect analyses were carried out as heterogeneity between studie...<br/><br/>Geneviève Van Maele-Fabry, Sophie Duhayon, Claire Mertens, Dominique Lison (2008) <i>Environ Res</i> <i></i> <i></i> 106: 1 121-137<br/>

http://publicationslist.org/d.lison/refid28 2010-11-13T08:46:46Z

Hard metals consist of tungsten carbide (WC) and metallic cobalt (Co) particles and are important industrial materials produced for their extreme hardness and high wear resistance properties. While occupational exposure to metallic Co alone is apparently not associated with an increased risk of cancer, the WC-Co particle mixture was shown to be carcinogenic in exposed workers. The in vitro mutagen...<br/><br/>Noömi Lombaert, Dominique Lison, Paul Van Hummelen, Micheline Kirsch-Volders (2008) <i>Toxicol Appl Pharmacol</i> <i></i> <i></i> 227: 2 299-312<br/>

http://publicationslist.org/d.lison/refid31 2010-11-13T08:46:46Z

OBJECTIVES: To review epidemiological studies which led to a change in the classification of formaldehyde by the International Agency for Research on Cancer (IARC) in 2004 as well as studies published thereafter, with the objective to examine whether occupational exposure levels for formaldehyde should be adapted. METHOD: Cohort and case-control studies investigating the association between occupa...<br/><br/>S Duhayon, P Hoet, G Van Maele-Fabry, D Lison (2008) <i>Int Arch Occup Environ Health</i> <i></i> <i></i> 81: 6 695-710<br/>

http://publicationslist.org/d.lison/refid27 2010-11-13T08:46:46Z

Information on the toxicity of carbon nanotubes is still fragmentary but indicates that these particles can induce adverse effects. We previously demonstrated in rats that, when purified multi-wall carbon nanotubes (MWCNT) reach the lung, they are biopersistent and induce lung inflammation as well as fibrosis. The present study was designed to address the genotoxic potential of this material in th...<br/><br/>Julie Muller, Ilse Decordier, Peter H Hoet, Noömi Lombaert, Leen Thomassen, François Huaux, Dominique Lison, Micheline Kirsch-Volders (2008) <i>Carcinogenesis</i> <i></i> <i></i> 29: 2 427-433<br/>

http://publicationslist.org/d.lison/refid32 2010-11-13T08:46:46Z

Dominique Lison, Julie Muller (2008) <i>Toxicol Sci</i> <i></i> <i></i> 101: 1 179-80; author reply 181-2<br/>

http://publicationslist.org/d.lison/refid30 2010-11-13T08:46:46Z

Organochlorines (polychlorinated biphenyls and dioxin-like compounds) are suspected to play a role in the etiopathogenesis of endometriosis. This hypothesis, based on experimental data, has been circulating for years in the scientific community and several epidemiologic surveys have attempted to obtain confirmatory human data. The purpose of this mini-review is to provide an overview of the twelve...<br/><br/>Jean-François Heilier, Jacques Donnez, Dominique Lison (2008) <i>Chemosphere</i> <i></i> <i></i> 71: 2 203-210<br/>

http://publicationslist.org/d.lison/refid26 2010-11-13T08:46:46Z

Noise is the most common preventable cause of irreversible sensorineural hearing loss. During recent years, the results of experimental and human investigations have raised the level of concern about the potential ototoxicity of chemical agents and their interaction with noise. European Directive 2003/10/EC on the minimum health and safety requirements regarding the exposure of workers to the risk...<br/><br/>Perrine Hoet, Dominique Lison (2008) <i>Crit Rev Toxicol</i> <i></i> <i></i> 38: 2 127-170<br/>

http://publicationslist.org/d.lison/refid24 2010-11-13T08:46:46Z

Carbon nanotubes (CNT) have been reported to elicit toxic responses in vitro and in vivo, ascribed so far to metal contamination, CNT length, degree of oxidation, or extent of hydrophilicity. To examine how structural properties may modulate the toxicity of CNT, one preparation of multiwall CNT has been modified (i) by grinding (introducing structural defects) and subsequently heating either in a ...<br/><br/>Ivana Fenoglio, Giovanna Greco, Maura Tomatis, Julie Muller, Encarnacion Raymundo-Piñero, François Béguin, Antonio Fonseca, Janos B Nagy, Dominique Lison, Bice Fubini (2008) <i>Chem Res Toxicol</i> <i></i> <i></i> 21: 9 1690-1697<br/>

http://publicationslist.org/d.lison/refid23 2010-11-13T08:46:46Z

Experimental studies indicate that carbon nanotubes (CNTs) have the potential to induce adverse pulmonary effects, including alveolitis, fibrosis, and genotoxicity in epithelial cells. Here, we explored the physicochemical determinants of these toxic responses with progressively and selectively modified CNTs: ground multiwall CNTs modified by heating at 600 degrees C (loss of oxygenated carbon fun...<br/><br/>Julie Muller, François Huaux, Antonio Fonseca, Janos B Nagy, Nicolas Moreau, Monique Delos, Encarnacion Raymundo-Piñero, François Béguin, Micheline Kirsch-Volders, Ivana Fenoglio, Bice Fubini, Dominique Lison (2008) <i>Chem Res Toxicol</i> <i></i> <i></i> 21: 9 1698-1705<br/>

http://publicationslist.org/d.lison/refid25 2010-11-13T08:46:46Z

Because of their small size and large specific surface area (SA), insoluble nanoparticles are almost not affected by the gravitational force and are generally formulated in stable suspensions or sols. This raises, however, a potential difficulty in in vitro assay systems in which cells adhering to the bottom of a culture vessel may not be exposed to the majority of nanoparticles in suspension. J. ...<br/><br/>Dominique Lison, Leen C J Thomassen, Virginie Rabolli, Laetitia Gonzalez, Dorota Napierska, Jin Won Seo, Micheline Kirsch-Volders, Peter Hoet, Christine E A Kirschhock, Johan A Martens (2008) <i>Toxicol Sci</i> <i></i> <i></i> 104: 1 155-162<br/>

http://publicationslist.org/d.lison/refid37 2010-11-13T08:46:46Z

Increased IL-9 expression, either systemically or under the control of lung-specific promoter, induces an asthma-like phenotype, including mucus overproduction, mastocytosis, lung eosinophilia, and airway hyperresponsiveness. These activities correlate with increased production of other Th2 cytokines such as IL-4, IL-5, and IL-13 in IL-9 Tg mice. To determine the exact role of IL-13 in this phenot...<br/><br/>Valérie Steenwinckel, Jamila Louahed, Ciriana Orabona, François Huaux, Guy Warnier, Andrew McKenzie, Dominique Lison, Roy Levitt, Jean-Christophe Renauld (2007) <i>J Immunol</i> <i></i> <i></i> 178: 5 3244-3251<br/>

http://publicationslist.org/d.lison/refid42 2010-11-13T08:46:46Z

It has been proposed that the development of lung fibrosis is associated with a T helper type 2 response, mainly characterized by IL-4 and IL-13 production. We investigated the potential role of type 2 immune polarization in the silicotic process and examined the pulmonary response to silica particles in mice genetically deficient for IL-4. We found that IL-4(-/-) mice were not protected against t...<br/><br/>Pierre Misson, Frank Brombacher, Monique Delos, Dominique Lison, Francois Huaux (2007) <i>Am J Physiol Lung Cell Mol Physiol</i> <i></i> <i></i> 292: 1 L107-L113<br/>

http://publicationslist.org/d.lison/refid43 2010-11-13T08:46:46Z

Peritoneal endometriosis (PE) and deep endometriotic nodules (DEN) are gynecological diseases recently shown to be associated with elevated serum concentrations of organochlorines. The objective of the present study was to compare risk factors associated with both forms of the disease, with a particular attention to potential sources of organochlorine exposure. This matched case-control study with...<br/><br/>Jean-François Heilier, Jacques Donnez, Fabienne Nackers, Réjane Rousseau, Violaine Verougstraete, Katrin Rosenkranz, Olivier Donnez, Frédéric Grandjean, Dominique Lison, René Tonglet (2007) <i>Environ Res</i> <i></i> <i></i> 103: 1 121-129<br/>

http://publicationslist.org/d.lison/refid36 2010-11-13T08:46:46Z

Ethylene oxide is considered as a human carcinogen. A biomarker of exposure would be a useful instrument to assess the risk in occupationally exposed workers. This cross-sectional study aimed at examining (a) whether the urinary excretion of a metabolite of ethylene oxide, 2-hydroxyethyl mercapturic acid (HEMA), could be used for monitoring occupational exposure and (b) whether glutathione S-trans...<br/><br/>Vincent Haufroid, Brigitte Merz, Annette Hofmann, Alois Tschopp, Dominique Lison, Philippe Hotz (2007) <i>Cancer Epidemiol Biomarkers Prev</i> <i></i> <i></i> 16: 4 796-802<br/>

http://publicationslist.org/d.lison/refid35 2010-11-13T08:46:46Z

OBJECTIVE: To conduct a systematic review and meta-analyses of published studies examining the association between myeloid leukemias (ML) and occupational pesticide exposure. METHODS: Studies were identified from a MEDLINE search through 31 May 2006 and from the reference lists of identified publications. Studies were summarized and evaluated for publication bias. Relative risk estimates for ML we...<br/><br/>Geneviève Van Maele-Fabry, Sophie Duhayon, Dominique Lison (2007) <i>Cancer Causes Control</i> <i></i> <i></i> 18: 5 457-478<br/>

http://publicationslist.org/d.lison/refid34 2010-11-13T08:46:46Z

IL-9 overexpression protects against alveolar fibrosis induced by crystalline silica particles. This cytokine is also involved in allergic asthma. In the present study, we examined the effect of IL-9 overexpression on the subepithelial fibrotic response, a feature of asthmatic remodeling, induced by chronic exposure to Alternaria alternata extract. IL-9-overexpressing mice (Tg5) and their wild-typ...<br/><br/>Sybille van den Brûle, Julie Heymans, Xavier Havaux, Jean-Christophe Renauld, Dominique Lison, François Huaux, Olivier Denis (2007) <i>Am J Respir Cell Mol Biol</i> <i></i> <i></i> 37: 2 202-209<br/>

http://publicationslist.org/d.lison/refid33 2010-11-13T08:46:46Z

OBJECTIVE: Tacrolimus is an immunosuppressive drug widely used in hepatic transplantation to avoid graft rejection. Its pharmacokinetics is characterized by a large interindividual variability requiring the use of therapeutic drug monitoring in daily clinical practice. Some genetic polymorphisms in biotransformation enzymes or transporter proteins, such as CYP3A5 and P-glycoprotein (ABCB1), in don...<br/><br/>Laure Elens, Arnaud Capron, Valérie Van Kerckhove, Jan Lerut, Michel Mourad, Dominique Lison, Pierre Wallemacq, Vincent Haufroid (2007) <i>Pharmacogenet Genomics</i> <i></i> <i></i> 17: 10 873-883<br/>

http://publicationslist.org/d.lison/refid46 2010-11-13T08:46:46Z

We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, ovarian endometriosis exhibits an 8-fold higher expression of aromatase, which sug...<br/><br/>Jean-François Heilier, Olivier Donnez, Valérie Van Kerckhove, Dominique Lison, Jacques Donnez (2006) <i>Fertil Steril</i> <i></i> <i></i> 85: 5 1516-1518<br/>

http://publicationslist.org/d.lison/refid47 2010-11-13T08:46:46Z

Carbon nanotubes (CNTs) currently attract intense research efforts because of their unique properties which make them suitable for many industrial applications. When inhaled, CNTs constitute a possible hazard to human health. Several studies have shown that when instilled in the lung of experimental animals, CNTs induced an inflammatory and fibrotic response similar to that caused by other toxic p...<br/><br/>Ivana Fenoglio, Maura Tomatis, Dominique Lison, Julie Muller, Antonio Fonseca, Janos B Nagy, Bice Fubini (2006) <i>Free Radic Biol Med</i> <i></i> <i></i> 40: 7 1227-1233<br/>

http://publicationslist.org/d.lison/refid48 2010-11-13T08:46:46Z

We previously showed that overexpression of IL-9 controls lung fibrosis induced by silica particles in mice (Arras and colleagues; Am J Respir Cell Mol Biol 2001;24:368-375). This protection was associated with an expansion of lung B lymphocytes. To explore the contribution of these cells in the protective effect of IL-9, we crossed IL-9 transgenic (IL-9+) and B-deficient (B-) mice. The antifibrot...<br/><br/>Mohammed Arras, Jamila Louahed, Vincent Simoen, Virginie Barbarin, Pierre Misson, Sybille van den Brûle, Monique Delos, Laurent Knoops, Jean-Christophe Renauld, Dominique Lison, François Huaux (2006) <i>Am J Respir Cell Mol Biol</i> <i></i> <i></i> 34: 5 573-580<br/>

http://publicationslist.org/d.lison/refid51 2010-11-13T08:46:46Z

BACKGROUND: The lead mobilization test reflects the mobilizable and likely toxicologically active fraction of the lead body burden. We propose a safe and convenient protocol for this test, to assess concomitant copper and zinc excretion and to determine the size of the chelatable lead pool in nonoccupationally exposed adults. METHODS: The study population included 80 white adults: 40 controls [med...<br/><br/>Perrine Hoet, Jean-Pierre Buchet, Laurence Decerf, Benoît Lavalleye, Vincent Haufroid, Dominique Lison (2006) <i>Clin Chem</i> <i></i> <i></i> 52: 1 88-96<br/>

http://publicationslist.org/d.lison/refid49 2010-11-13T08:46:46Z

Styrene oxide (SO), ethylene oxide (EO) and gamma-radiation (G) are agents with a well-described metabolism and genotoxicity. EPHX1 and GSTs play an important role in the detoxification of electrophiles and oxidative stress. Enzymes involved in base excision repair (hOGG1, XRCC1), in rejoining single strand breaks (XRCC1) and in repair of cross-links and chromosomal double strand breaks (XRCC3) mi...<br/><br/>Lode Godderis, Peter Aka, Raluca Mateuca, Micheline Kirsch-Volders, Dominique Lison, Hendrik Veulemans (2006) <i>Toxicology</i> <i></i> <i></i> 219: 1-3 220-229<br/>

http://publicationslist.org/d.lison/refid45 2010-11-13T08:46:46Z

PURPOSE: The purpose of the present paper is to review cohort studies that examined the occurrence of prostate cancer in pesticide manufacturing workers in order to undertake a qualitative and quantitative evaluation of the risk as well as to assess the level of epidemiological evidence for each class of chemical compounds. METHODS: Following a systematic literature search, relative risk (RR) esti...<br/><br/>Geneviève Van Maele-Fabry, Valérie Libotte, Jan Willems, Dominique Lison (2006) <i>Cancer Causes Control</i> <i></i> <i></i> 17: 4 353-373<br/>

http://publicationslist.org/d.lison/refid38 2010-11-13T08:46:46Z

Dioxin-like compounds (DLCs) are suspected etiological factors of endometriosis but their potential mechanisms of action remain elusive. Because endometriosis is an estrogen-dependent disease and since aromatase (CYP19), a key enzyme in estrogen biosynthesis, was recently demonstrated to be expressed in endometriotic lesions, we hypothesized that dioxin-like compounds could modulate local estrogen...<br/><br/>Jean-François Heilier, Jacques Donnez, Sylvie Defrere, Valérie Van Kerckhove, Olivier Donnez, Dominique Lison (2006) <i>Toxicol Lett</i> <i></i> <i></i> 167: 3 238-244<br/>

http://publicationslist.org/d.lison/refid39 2010-11-13T08:46:46Z

BACKGROUND: Inflammation plays a critical role in lung disease development and progression in cystic fibrosis. Azithromycin is used for the treatment of cystic fibrosis lung disease, although its mechanisms of action are poorly understood. We tested the hypothesis that azithromycin modulates lung inflammation in cystic fibrosis mice. METHODS: We monitored cellular and molecular inflammatory marker...<br/><br/>Rachida Legssyer, François Huaux, Jean Lebacq, Monique Delos, Etienne Marbaix, Patrick Lebecque, Dominique Lison, Bob J Scholte, Pierre Wallemacq, Teresinha Leal (2006) <i>Respir Res</i> <i></i> <i></i> 7: <br/>

http://publicationslist.org/d.lison/refid40 2010-11-13T08:46:46Z

Genetic polymorphisms in biotransformation enzyme CYP3A5 (6986G > A, CYP3A5*3; 14690A > G, CYP3A5*6) and drug transporter ABCB1 (1236C > T; 2677G > T/A; 3435C > T) are known to influence tacrolimus (Tac) dose requirements and trough blood levels in stable transplant patients. In a group of 19 volunteers selected with relevant genotypes among a list of 221 adult renal transplant candidates, we eval...<br/><br/>V Haufroid, P Wallemacq, V VanKerckhove, L Elens, M De Meyer, D C Eddour, J Malaise, D Lison, M Mourad (2006) <i>Am J Transplant</i> <i></i> <i></i> 6: 11 2706-2713<br/>

http://publicationslist.org/d.lison/refid44 2010-11-13T08:46:46Z

OBJECTIVES: Cadmium (Cd) and lead (Pb) have been demonstrated to exert endocrine disrupting activities. Their possible role in endometriosis, an oestrogen-dependent disease, is unknown. METHODS: We compared cadmium urinary excretion (CdU) and blood concentration of cadmium (CdB) and lead (PbB) in 119 patients with peritoneal endometriosis and/or deep endometriotic (adenomyotic) nodules of the rect...<br/><br/>J F Heilier, J Donnez, V Verougstraete, O Donnez, F Grandjean, V Haufroid, F Nackers, D Lison (2006) <i>Int Arch Occup Environ Health</i> <i></i> <i></i> 80: 2 149-153<br/>

http://publicationslist.org/d.lison/refid41 2010-11-13T08:46:46Z

BACKGROUND: Cytochrome P450 3A5 (CYP3A5) and ABCB1 polymorphisms have been shown to influence tacrolimus (Tc) blood concentrations in the stable phase after organ transplantation. We hypothesized that Tc pharmacokinetics may be affected by genetic mutations subsequent to starting doses. METHODS: We retrospectively analyzed data from a cohort of 59 kidney transplant recipients, in whom CYP3A5 (intr...<br/><br/>Michel Mourad, Pierre Wallemacq, Martine De Meyer, Dimitri Brandt, Valérie Van Kerkhove, Jacques Malaise, Djamila Chaïb Eddour, Dominique Lison, Vincent Haufroid (2006) <i>Clin Chem Lab Med</i> <i></i> <i></i> 44: 10 1192-1198<br/>

http://publicationslist.org/d.lison/refid60 2010-11-13T08:46:46Z

OBJECTIVE: Interpretation of urinary arsenic measurements is sometimes difficult because of the absorption of seafood that contains trimethylated arsenic forms (arsenobetaine and arsenocholine). The objective of this study was to develop a rapid and robust technique for the measurement of the sum of inorganic arsenic metabolites. METHODS: Measurement of arsenic was performed in urine after hydride...<br/><br/>Jean-François Heilier, Jean-Pierre Buchet, Vincent Haufroid, Dominique Lison (2005) <i>Int Arch Occup Environ Health</i> <i></i> <i></i> 78: 1 51-59<br/>

http://publicationslist.org/d.lison/refid59 2010-11-13T08:46:46Z

Identification of genetic polymorphisms responsible for reduced DNA repair capacity may allow better cancer prevention. We examined whether variations in genes involved in base-excision (hOGG1, XRCC1) and double strand break (XRCC3) DNA repair contribute to inter-individual differences in genotoxic effects induced in the lymphocytes of 21 cobalt (Co) exposed, 26 hard metal (WC-Co) exposed and 26 m...<br/><br/>R Mateuca, P V Aka, M De Boeck, R Hauspie, M Kirsch-Volders, D Lison (2005) <i>Toxicol Lett</i> <i></i> <i></i> 156: 2 277-288<br/>

http://publicationslist.org/d.lison/refid61 2010-11-13T08:46:46Z

V Verougstraete, D Lison (2005) <i>Toxicol Appl Pharmacol</i> <i></i> <i></i> 203: 1 88-9; author reply 89-90<br/>

http://publicationslist.org/d.lison/refid64 2010-11-13T08:46:46Z

The induction of cytochrome P4502E1 (CYP2E1) is believed to play a role in the development of fibrosis in hepatitis C patients. However, information about CYP2E1 activity in chronic hepatitis C patients is fragmentary and the relationship between CYP2E1 activity and mRNA expression is unknown in this disease. The purpose of this study was (a) to characterise CYP2E1 activity in those patients and (...<br/><br/>Vincent Haufroid, Danuta Ligocka, Pierre Wallemacq, Dominique Lison, Yves Horsmans (2005) <i>Toxicol Lett</i> <i></i> <i></i> 155: 1 171-177<br/>

http://publicationslist.org/d.lison/refid58 2010-11-13T08:46:46Z

Ph Hantson, O Van Caenegem, I Decordier, V Haufroid, D Lison (2005) <i>Clin Toxicol (Phila)</i> <i></i> <i></i> 43: 2 111-112<br/>

http://publicationslist.org/d.lison/refid63 2010-11-13T08:46:46Z

Chronic inflammation and proinflammatory cytokines as well as T helper type 2 (Th2) cytokines have been involved in the pathogenesis of pulmonary injury and lung fibrosis. The actual role of IL-10 in lung fibrosis is still unclear because this cytokine has been identified as Th2 but possesses strong anti-inflammatory properties. To better dissect the potential role of IL-10 in silica-induced lung ...<br/><br/>Virginie Barbarin, Zhou Xing, Monique Delos, Dominique Lison, Francois Huaux (2005) <i>Am J Physiol Lung Cell Mol Physiol</i> <i></i> <i></i> 288: 5 L841-L848<br/>

http://publicationslist.org/d.lison/refid62 2010-11-13T08:46:46Z

IL-9 is a Th2 cytokine that exerts pleiotropic activities, and might be involved in the regulation of lung inflammatory processes. To characterize the activity of IL-9 on lung injury, we compared the pulmonary responses to bleomycin (blm) in IL-9 transgenic (Tg5) and wild-type (FVB) mice. Following intratracheal instillation of lethal doses of blm, the mortality rate was markedly reduced in Tg5 mi...<br/><br/>Mohammed Arras, Jamila Louahed, Jean-François Heilier, Monique Delos, Frank Brombacher, Jean-Christophe Renauld, Dominique Lison, François Huaux (2005) <i>Am J Pathol</i> <i></i> <i></i> 166: 1 107-115<br/>

http://publicationslist.org/d.lison/refid56 2010-11-13T08:46:46Z

Toxic causes of seizures are numerous: alcohol and other substances of abuse, drugs, and industrial and household products. However, in the absence of a clearly suggestive history and/or associated symptoms and signs, identification of the toxic origin of new-onset seizures may be extremely difficult. We report here the case of a patient admitted in our hospital after a single generalized tonic-cl...<br/><br/>Roger Denays, Claudine Kumba, Dominique Lison, David De Bels (2005) <i>Epilepsia</i> <i></i> <i></i> 46: 6 961-962<br/>

http://publicationslist.org/d.lison/refid57 2010-11-13T08:46:46Z

A minireview is presented concerning the use of mercapturic acids as biological exposure index for electrophilic chemicals. Besides pure analytical aspects, this minireview considers possible issues in relation to (a) the added value of mercapturic acids as compared to other well validated biomarkers of exposure and (b) the high inter-individual variability in mercapturic acids excretion. Recent f...<br/><br/>V Haufroid, D Lison (2005) <i>Int Arch Occup Environ Health</i> <i></i> <i></i> 78: 5 343-354<br/>

http://publicationslist.org/d.lison/refid50 2010-11-13T08:46:46Z

BACKGROUND: CYP3A5 and MDR1 polymorphisms have been shown to influence tacrolimus blood concentrations and dose requirements. The aim is to determine whether these polymorphisms also affect sirolimus trough concentrations and dose requirements after kidney transplantation. METHODS: Eighty-five renal transplant recipients receiving sirolimus were included. Twenty-four were treated with a combined s...<br/><br/>Michel Mourad, Georges Mourad, Pierre Wallemacq, Valérie Garrigue, Christophe Van Bellingen, Valérie Van Kerckhove, Martine De Meyer, Jacques Malaise, Djamila Chaib Eddour, Dominique Lison, Jean Paul Squifflet, Vincent Haufroid (2005) <i>Transplantation</i> <i></i> <i></i> 80: 7 977-984<br/>

http://publicationslist.org/d.lison/refid53 2010-11-13T08:46:46Z

Carbon nanotubes focus the attention of many scientists because of their huge potential of industrial applications, but there is a paucity of information on the toxicological properties of this material. The aim of this experimental study was to characterize the biological reactivity of purified multi-wall carbon nanotubes in the rat lung and in vitro. Multi-wall carbon nanotubes (CNT) or ground C...<br/><br/>Julie Muller, François Huaux, Nicolas Moreau, Pierre Misson, Jean-François Heilier, Monique Delos, Mohammed Arras, Antonio Fonseca, Janos B Nagy, Dominique Lison (2005) <i>Toxicol Appl Pharmacol</i> <i></i> <i></i> 207: 3 221-231<br/>

http://publicationslist.org/d.lison/refid52 2010-11-13T08:46:46Z

BACKGROUND: It has been generally well accepted that chronic inflammation is a necessary component of lung fibrosis but this concept has recently been challenged. METHODS: Using biochemical, histological, immunohistochemistry, and cellular analyses, we compared the lung responses (inflammation and fibrosis) to fibrogenic silica particles (2.5 and 25 mg/g lung) in Sprague-Dawley rats and NMRI mice....<br/><br/>Virginie Barbarin, Aurélie Nihoul, Pierre Misson, Mohammed Arras, Monique Delos, Isabelle Leclercq, Dominique Lison, Francois Huaux (2005) <i>Respir Res</i> <i></i> <i></i> 6: <br/>

http://publicationslist.org/d.lison/refid54 2010-11-13T08:46:46Z

OBJECTIVE: To investigate the possible association between the body burden of dioxin-like compounds and endometriotic disease. DESIGN: Case-control study. SETTING: Gynecology ward in a university hospital. PATIENT(S): Seventy-one women with peritoneal endometriosis (n = 25) or deep endometriotic (adenomyotic) nodules (n = 25) and controls (n = 21). INTERVENTION(S): Collection of 200 mL of blood (f...<br/><br/>Jean-François Heilier, Fabienne Nackers, Violaine Verougstraete, René Tonglet, Dominique Lison, Jacques Donnez (2005) <i>Fertil Steril</i> <i></i> <i></i> 84: 2 305-312<br/>

http://publicationslist.org/d.lison/refid55 2010-11-13T08:46:46Z

BACKGROUND: Lung fibrosis is characterized by tissue remodeling resulting from an imbalance between synthesis and degradation of extracellular organic matrices. To examine whether cathepsin(s) (Cat) are important in the development of pulmonary fibrosis, we assessed the expression of four Cat known for their collagenolytic activity in a model of silica-induced lung fibrosis. METHODS: Different str...<br/><br/>Sybille van den Brûle, Pierre Misson, Frank Bühling, Dominique Lison, François Huaux (2005) <i>Respir Res</i> <i></i> <i></i> 6: <br/>

http://publicationslist.org/d.lison/refid71 2010-11-13T08:46:46Z

PURPOSE: The purpose of this study was to determine the immunization efficacy of antigen and DNA vaccines after delivery to the lung, to assess the integrity of the pulmonary tissue after vaccination, and to elucidate mechanisms involved in the induction of immunity. METHODS: Ovalbumin, the plasmid encoding ovalbumin, the hepatitis B surface antigen (HBsAg), or plasmid encoding HBsAg were intratra...<br/><br/>Catherine Lombry, Aline Marteleur, Mohammed Arras, Dominique Lison, Jamila Louahed, Jean-Christophe Renauld, Véronique Préat, Rita Vanbever (2004) <i>Pharm Res</i> <i></i> <i></i> 21: 1 127-135<br/>

http://publicationslist.org/d.lison/refid70 2010-11-13T08:46:46Z

The objective of the study was to examine the influence of cobalt exposure on lung function changes in workers from a cobalt-producing plant in a health monitoring program implemented between 1988 and 2001. A total of 122 male workers with at least 4 (median = 6) lung function tests (FEV(1) and FVC) during the follow-up period were assessed longitudinally. Cobalt exposure significantly decreased o...<br/><br/>Violaine Verougstraete, Alex Mallants, Jean-Pierre Buchet, Bert Swennen, Dominique Lison (2004) <i>Am J Respir Crit Care Med</i> <i></i> <i></i> 170: 2 162-166<br/>

http://publicationslist.org/d.lison/refid73 2010-11-13T08:46:46Z

The sum of bulk polychlorobiphenyl levels was significantly higher in women with rectovaginal adenomyosis than in women with endometriosis and controls.<br/><br/>Jean-François Heilier, Anh Thi Ha, Dominique Lison, Jacques Donnez, René Tonglet, Fabienne Nackers (2004) <i>Fertil Steril</i> <i></i> <i></i> 81: 2 456-458<br/>

http://publicationslist.org/d.lison/refid69 2010-11-13T08:46:46Z

Cyclosporine and tacrolimus are immunosuppressive drugs largely used in renal transplantation. They are characterized by a wide inter-individual variability in their pharmacokinetics with a potential impact on their therapeutic efficacy or induced toxicity. CYP3A5 and P-glycoprotein appear as important determinants of the metabolism of these drugs. The objective of this study was to investigate th...<br/><br/>Vincent Haufroid, Michel Mourad, Valérie Van Kerckhove, Jeremie Wawrzyniak, Martine De Meyer, Djamila Chaib Eddour, Jacques Malaise, Dominique Lison, Jean-Paul Squifflet, Pierre Wallemacq (2004) <i>Pharmacogenetics</i> <i></i> <i></i> 14: 3 147-154<br/>

http://publicationslist.org/d.lison/refid72 2010-11-13T08:46:46Z

We previously described a reduction of silica-induced lung fibrosis in interleukin-10-deficient mice (IL-10-/-) (Huaux and colleagues; Am. J. Respir. Cell Mol. Biol. 1998;18:51-59). In the present study, we further dissect the exact functions of IL-10 in experimental silicosis. The reduced lung fibrotic response to silica in IL-10-/- mice was accompanied by a marked recruitment of TH1 CD4+ lymphoc...<br/><br/>Virginie Barbarin, Mohammed Arras, Pierre Misson, Monique Delos, Bridget McGarry, Sem H Phan, Dominique Lison, François Huaux (2004) <i>Am J Respir Cell Mol Biol</i> <i></i> <i></i> 31: 1 78-85<br/>

http://publicationslist.org/d.lison/refid67 2010-11-13T08:46:46Z

A study on 44 workers exposed to styrene and 44 matched referents was performed in order to examine the influence of genetic polymorphisms in biotransformation and DNA repair enzymes on the levels of N-terminal hemoglobin adducts and genotoxicity biomarkers. Urinary mandelic acid concentration averaged 201.57 mg/g creatinine +/-148.32 in exposed workers, corresponding to a calculated average airbo...<br/><br/>Lode Godderis, Marlies De Boeck, Vincent Haufroid, Muriel Emmery, Raluca Mateuca, Sophie Gardinal, Micheline Kirsch-Volders, Hendrik Veulemans, Dominique Lison (2004) <i>Environ Mol Mutagen</i> <i></i> <i></i> 44: 4 293-303<br/>

http://publicationslist.org/d.lison/refid68 2010-11-13T08:46:46Z

Macrophages are characterized by a marked phenotypic heterogeneity depending on their microenvironmental stimulation. Beside classical activation (M1), it has been shown that macrophages could follow a different activation pathway after stimulation with interleukin (IL)-4 or IL-13 (M2). Recently, it has been postulated that those "alternatively activated" macrophages may be critical in the control...<br/><br/>Pierre Misson, Sybille van den Brûle, Virginie Barbarin, Dominique Lison, François Huaux (2004) <i>J Leukoc Biol</i> <i></i> <i></i> 76: 5 926-932<br/>

http://publicationslist.org/d.lison/refid66 2010-11-13T08:46:46Z

The present study aimed at comparing in vitro the apoptogenic properties of metallic cobalt (Co), tungsten carbide (WC) and tungsten carbide-cobalt (WC-Co) in conditions known to cause genotoxicity. Human peripheral blood mononucleated cells were incubated with 2.0-6.0 microg/ml of Co alone or mixed with WC particles and 33.3-100.0 microg/ml WC alone for up to 24 h. Under these culture conditions ...<br/><br/>Noömi Lombaert, Marlies De Boeck, Ilse Decordier, Enrico Cundari, Dominique Lison, Micheline Kirsch-Volders (2004) <i>Toxicol Lett</i> <i></i> <i></i> 154: 1-2 23-34<br/>

http://publicationslist.org/d.lison/refid65 2010-11-13T08:46:46Z

Environmental chemicals with oestrogen-like activity are suspected aetiological factors of endometriosis. In animal experiments, cadmium was recently shown to possess oestrogen-like properties. In the frame of a case-control study designed to investigate environmental risk factors for endometriosis, we compared cadmium urinary excretion (CdU) and blood concentration in 59 patients with peritoneal ...<br/><br/>Jean-François Heilier, Violaine Verougstraete, Fabienne Nackers, René Tonglet, Jacques Donnez, Dominique Lison (2004) <i>Toxicol Lett</i> <i></i> <i></i> 154: 1-2 89-93<br/>

http://publicationslist.org/d.lison/refid84 2010-11-13T08:46:46Z

Chromium-based catalysts are used for the synthesis of polyethylene, but little is known about the hazard and biomonitoring possibilities of this type of chromium for workers who may be occupationally exposed to such compounds. Therefore, the bioavailability and toxicokinetics of chromium were studied in male Wistar rats after a single intratracheal instillation (2 ml/kg body weight) of various do...<br/><br/>J A J Vanoirbeek, P H M Hoet, B Nemery, E K Verbeken, V Haufroid, D Lison, D Dinsdale (2003) <i>J Toxicol Environ Health A</i> <i></i> <i></i> 66: 4 393-409<br/>

http://publicationslist.org/d.lison/refid81 2010-11-13T08:46:46Z

OBJECTIVE: In mice, the renal toxicity of arsenic (As) and cadmium (Cd) has been shown to be exacerbated by the simultaneous administration of both elements. To verify the existence of such an interaction in humans, cohorts slightly (Belgian) and moderately (Chinese) exposed to both elements were examined. METHODS: Biological indicators of exposure (Cd in urine and in blood; As in urine) and renal...<br/><br/>Jean-Pierre Buchet, Jean-François Heilier, Alfred Bernard, Dominique Lison, Taiyi Jin, Xunwei Wu, Qinhu Kong, Gunnar Nordberg (2003) <i>Int Arch Occup Environ Health</i> <i></i> <i></i> 76: 2 111-120<br/>

http://publicationslist.org/d.lison/refid82 2010-11-13T08:46:46Z

The aim of this work was to prepare and characterize inhalation dry powders of human parathyroid hormone (PTH), as well as to assess their efficacy for systemic delivery of the peptide and safety in rats. The powders were prepared by spray-drying using PTH, sugars, dipalmitoylphosphatidylcholine, and/or albumin. They presented an average primary particle diameter of 4.5 microm and tap density of 0...<br/><br/>Valérie Codrons, Francis Vanderbist, Roger K Verbeeck, Mohammed Arras, Dominique Lison, Véronique Préat, Rita Vanbever (2003) <i>J Pharm Sci</i> <i></i> <i></i> 92: 5 938-950<br/>

http://publicationslist.org/d.lison/refid83 2010-11-13T08:46:46Z

Occupational exposure to hard metal dust, consisting of tungsten carbide (WC) and metallic cobalt particles (Co), is associated with an increased risk of lung cancer, while no increased risk was observed in workers exposed to Co alone. In vitro, in human peripheral blood mononucleated cells (PBMC), we previously demonstrated that WC-Co is more genotoxic than Co and WC alone. A possible mechanism u...<br/><br/>Marlies De Boeck, Noömi Lombaert, Sofie De Backer, Robert Finsy, Dominique Lison, Micheline Kirsch-Volders (2003) <i>Mutagenesis</i> <i></i> <i></i> 18: 2 177-186<br/>

http://publicationslist.org/d.lison/refid79 2010-11-13T08:46:46Z

OBJECTIVE: Cytochrome P4502E1 (CYP2E1) is expressed in human peripheral blood lymphocytes (PBLs), and previous reports have suggested the possibility of using this readily available tissue as a reporter of CYP2E1 status. To further explore the relevance of this approach we assessed CYP2E1 expression in PBLs in two contrasting conditions, chronic hepatitis C and insulin-dependent diabetes (IDD), il...<br/><br/>Vincent Haufroid, Danuta Ligocka, Martin Buysschaert, Yves Horsmans, Dominique Lison (2003) <i>Eur J Clin Pharmacol</i> <i></i> <i></i> 59: 1 29-33<br/>

http://publicationslist.org/d.lison/refid80 2010-11-13T08:46:46Z

The involvement of cytochrome P450 2E1 (CYP2E1) in the metabolism of N-methyl-2-pyrrolidone (NMP) was studied with three experimental approaches: in the rat, in vitro in human microsomes, and in human volunteers. NMP was administered dermally (40 mg/kg) to OFA rats to examine the influence of CYP2E1 inhibition (5 mg/kg diethyldithiocarbamate, DETC, 30 min before) and CYP2E1 induction (after 4 days...<br/><br/>Danuta Ligocka, Dominique Lison, Vincent Haufroid (2003) <i>Arch Toxicol</i> <i></i> <i></i> 77: 5 261-266<br/>

http://publicationslist.org/d.lison/refid78 2010-11-13T08:46:46Z

Cadmium (Cd) and its compounds were classified as "carcinogenic to humans (Group 1)" by IARC in 1993. The observation of an increased number of lung cancers in a U.S. cohort of cadmium-exposed workers and the finding of tumors in animals exposed to various cadmium compounds apparently played an important role in this assessment. Since this evaluation, several cohorts of cadmium exposed workers hav...<br/><br/>Violaine Verougstraete, Dominique Lison, Philippe Hotz (2003) <i>J Toxicol Environ Health B Crit Rev</i> <i></i> <i></i> 6: 3 227-255<br/>

http://publicationslist.org/d.lison/refid74 2010-11-13T08:46:46Z

The purpose of this review is to summarise the data concerning genotoxicity and carcinogenicity of Co and Sb. Both metals have multiple industrial and/or therapeutical applications, depending on the considered species. Cobalt is used for the production of alloys and hard metal (cemented carbide), diamond polishing, drying agents, pigments and catalysts. Occupational exposure to cobalt may result i...<br/><br/>Marlies De Boeck, Micheline Kirsch-Volders, Dominique Lison (2003) <i>Mutat Res</i> <i></i> <i></i> 533: 1-2 135-152<br/>

http://publicationslist.org/d.lison/refid75 2010-11-13T08:46:46Z

This study investigated cytokine protein levels (interleukin-12 p70 [IL-12p70], p40, and IL-10) in bronchoalveolar lavage fluid (BALF) from patients with pulmonary sarcoidosis (n = 59), healthy control subjects (n = 17), and patients with idiopathic pulmonary fibrosis (IPF) (n = 30). The relationship between cytokine levels and clinical course of sarcoidosis was also examined. Overall, p40 was far...<br/><br/>Virginie Barbarin, Martin Petrek, Vitezslav Kolek, Jacques Van Snick, François Huaux, Dominique Lison (2003) <i>J Interferon Cytokine Res</i> <i></i> <i></i> 23: 8 449-456<br/>

http://publicationslist.org/d.lison/refid76 2010-11-13T08:46:46Z

M Kirsch-Volders, D Lison (2003) <i>Carcinogenesis</i> <i></i> <i></i> 24: 11 1853-4; author reply 1855-7<br/>

http://publicationslist.org/d.lison/refid77 2010-11-13T08:46:46Z

Inhalation of hard metal dust (WC-Co particles) has been associated with an increased risk for lung cancer in occupational settings. In vitro, WC-Co was genotoxic in human lymphocytes producing DNA strand breaks and micronuclei. The aim of the present study was to evaluate the in vivo genotoxic effects of WC-Co dust in rat type II pneumocytes. DNA breaks/alkali-labile sites (alkaline comet assay) ...<br/><br/>Marlies De Boeck, Peter Hoet, Noömi Lombaert, Benoit Nemery, Micheline Kirsch-Volders, Dominique Lison (2003) <i>Carcinogenesis</i> <i></i> <i></i> 24: 11 1793-1800<br/>

http://publicationslist.org/d.lison/refid89 2010-11-13T08:46:46Z

The p40 subunit of IL-12 (IL-12p40), but not the heterodimeric form IL-12p70, is secreted during the development of silica-induced lung fibrosis in C57BL/6 mice. To delineate the contribution of IL-12p40 to the lung inflammatory and fibrotic processes, we compared the pulmonary responses with silica particles of IL-12p35-deficient mice (IL-12p35(-/-), able to produce IL-12p40) and IL-12p40-deficie...<br/><br/>Francois Huaux, Mohammed Arras, David Tomasi, Virginie Barbarin, Monique Delos, Jean-Paul Coutelier, Anne Vink, Sem H Phan, Jean-Christophe Renauld, Dominique Lison (2002) <i>J Immunol</i> <i></i> <i></i> 169: 5 2653-2661<br/>

http://publicationslist.org/d.lison/refid90 2010-11-13T08:46:46Z

The present paper describes the outbreak of health complaints that occurred in Belgium, in June 1999, among schoolchildren and members of the general public in relation to the consumption of Coca-Cola and other soft drinks. The outbreak took place in the wake of a major food crisis, caused by PCB/dioxin contamination of animal feed, that had erupted shortly before. The clinical features (absence o...<br/><br/>B Nemery, B Fischler, M Boogaerts, D Lison, J Willems (2002) <i>Food Chem Toxicol</i> <i></i> <i></i> 40: 11 1657-1667<br/>

http://publicationslist.org/d.lison/refid88 2010-11-13T08:46:46Z

The aim of this work was to validate a sensitive method for quantitative analysis of 5-hydroxy-N-methylpyrrolidone (5-HNMP) in urine. This compound has been recommended as a marker for biological monitoring of N-methylpyrrolidone (NMP) exposure. Different solvents and alternative methods of extraction including liquid-liquid extraction (LLE) on Chem Elut and solid-phase extraction (SPE) on Oasis H...<br/><br/>D Ligocka, D Lison, V Haufroid (2002) <i>J Chromatogr B Analyt Technol Biomed Life Sci</i> <i></i> <i></i> 778: 1-2 223-230<br/>

http://publicationslist.org/d.lison/refid91 2010-11-13T08:46:46Z

OBJECTIVES: To analyse the relationship between cytochrome P4502E1 (CYP2E1) activity as assessed by the chlorzoxazone metabolic ratio (CMR) and frequent CYP2E1 genotypes ( CYP2E1*5B, *6, *1B and *1D) and to assess the value of CMR in refining the biomonitoring of exposure to styrene. METHODS: Thirty-one workers from a fibreglass-reinforced plastics factory took part in the study. Ambient styrene c...<br/><br/>Vincent Haufroid, Jean-Pierre Buchet, Sophie Gardinal, Dominique Lison (2002) <i>Int Arch Occup Environ Health</i> <i></i> <i></i> 75: 7 453-458<br/>

http://publicationslist.org/d.lison/refid85 2010-11-13T08:46:46Z

Cytokines are important mediators of the pathogenesis of lung fibrosis. The experimental studies carried out in our laboratory have used a murine model of lung silicosis to explore the activity of interleukin-9, -10 and -12. The data presented in this short overview illustrate the pro-fibrotic activity of anti-inflammatory cytokines (IL-10), and the role of type 2 immune polarisation, as illustrat...<br/><br/>D Lison (2002) <i>Bull Mem Acad R Med Belg</i> <i></i> <i></i> 157: 3-4 205-11; discussion 211-3<br/>

http://publicationslist.org/d.lison/refid86 2010-11-13T08:46:46Z

In the field of occupational and/or environmental toxicology, the measurement of specific metabolites in urine may serve to assess exposure to the parent compounds (biological monitoring of exposure). Styrene is one of the chemicals for which biological monitoring programs have been validated and implemented in environmental and occupational medicine. However, inter-individual differences in the u...<br/><br/>Vincent Haufroid, Marek Jakubowski, Beata Janasik, Danuta Ligocka, Jean-Pierre Buchet, Enrico Bergamaschi, Paola Manini, Antonio Mutti, Sergio Ghittori, Michael Arand, Nina Hangen, Franz Oesch, Ari Hirvonen, Dominique Lison (2002) <i>Pharmacogenetics</i> <i></i> <i></i> 12: 9 691-702<br/>

http://publicationslist.org/d.lison/refid87 2010-11-13T08:46:46Z

HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane), a substitute for the banned chlorofluorocarbons (CFCs), is a structural analogue of the well-known hepatotoxicant halothane. The objectives of these experiments were to investigate (1) whether, like halothane, multiple exposure increases the risk of HCFC-123-induced liver toxicity, and (2) whether ethanol, a potent CYP2E1 inducer, potentiates the live...<br/><br/>Perrine Hoet, Jean-Pierre Buchet, Christine Sempoux, Vincent Haufroid, Jacques Rahier, Dominique Lison (2002) <i>Arch Toxicol</i> <i></i> <i></i> 76: 12 707-714<br/>

http://publicationslist.org/d.lison/refid92 2010-11-13T08:46:46Z

BACKGROUND: Exposure to cadmium fumes or dusts has been associated with an increased risk of lung cancer and the characterisation of the genotoxic potential of cadmium compounds is, among other possible mechanisms, an important element in the assessment of the carcinogenic hazard of the element. While there is some evidence that in experimental systems, cadmium compounds may exert genotoxic effect...<br/><br/>Violaine Verougstraete, Dominique Lison, Philippe Hotz (2002) <i>Mutat Res</i> <i></i> <i></i> 511: 1 15-43<br/>

http://publicationslist.org/d.lison/refid97 2010-11-13T08:46:46Z

V Haufroid, F Toubeau, A Clippe, M Buysschaert, J L Gala, D Lison (2001) <i>Clin Chem</i> <i></i> <i></i> 47: 6 1126-1129<br/>

http://publicationslist.org/d.lison/refid98 2010-11-13T08:46:46Z

We examined the effect of interleukin (IL)-9, a cytokine active on B and T lymphocytes and associated with bronchial asthma, on the development of lung fibrosis induced by crystalline silica particles. Therefore, we compared the response to silica (1 and 5 mg/animal, intratracheally) in transgenic mice that constitutively express high levels of IL-9 (Tg5) and their wild-type counterparts (FVB). At...<br/><br/>M Arras, F Huaux, A Vink, M Delos, J P Coutelier, M C Many, V Barbarin, J C Renauld, D Lison (2001) <i>Am J Respir Cell Mol Biol</i> <i></i> <i></i> 24: 4 368-375<br/>

http://publicationslist.org/d.lison/refid95 2010-11-13T08:46:46Z

OBJECTIVE: To integrate recent understandings of the mechanisms of genotoxicity and carcinogenicity of the different cobalt compounds. METHOD: A narrative review of the studies published since the last IARC assessment in 1991 (genotoxicity, experimental carcinogenesis, and epidemiology). RESULTS: Two different mechanisms of genotoxicity, DNA breakage induced by cobalt metal and especially hard met...<br/><br/>D Lison, M De Boeck, V Verougstraete, M Kirsch-Volders (2001) <i>Occup Environ Med</i> <i></i> <i></i> 58: 10 619-625<br/>

http://publicationslist.org/d.lison/refid96 2010-11-13T08:46:46Z

2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123) has been developed as a substitute for ozone-depleting chlorofluorocarbons (CFCs). It is a structural analogue of halothane and similarities in the metabolic pathways and liver toxicity of both compounds have been described. The present study was initiated after an accidental outbreak of hepatitis in an industrial setting to examine whether concomitant...<br/><br/>P Hoet, J P Buchet, C Sempoux, T Nomiyama, J Rahier, D Lison (2001) <i>Arch Toxicol</i> <i></i> <i></i> 75: 5 274-283<br/>

http://publicationslist.org/d.lison/refid94 2010-11-13T08:46:46Z

OBJECTIVES: This study examined whether consideration of the *1C/*1D CYP2E1 insertion polymorphism is important for interpreting the biological monitoring of exposure to N,N-dimethylformamide (DMF) in Japanese workers. METHODS: The insertion genotype, airborne DMF exposure on the last day of a work week, and NMF in urine sampled just after the last workshift of the week were determined in 44 male ...<br/><br/>T Nomiyama, V Haufroid, J P Buchet, H Miyauchi, S Tanaka, T Yamauchi, S Imamiya, Y Seki, K Omae, D Lison (2001) <i>Int Arch Occup Environ Health</i> <i></i> <i></i> 74: 7 519-522<br/>

http://publicationslist.org/d.lison/refid93 2010-11-13T08:46:46Z

The purpose of this review is to describe the present state of knowledge regarding host susceptibility factors that may determine the occurrence, development and severity of interstitial lung disease (ILD) caused by exogenous agents. First, host susceptibility may pertain to differences in the delivery and/or persistence of the noxious agent in the lung. The deposition and clearance of inhaled par...<br/><br/>B Nemery, A Bast, J Behr, P J Borm, S J Bourke, P H Camus, P De Vuyst, H M Jansen, V L Kinnula, D Lison, O Pelkonen, C Saltini (2001) <i>Eur Respir J Suppl</i> <i></i> <i></i> 32: 30s-42s<br/>

http://publicationslist.org/d.lison/refid103 2010-11-13T08:46:46Z

D Lison (2000) <i>AIHAJ</i> <i></i> <i></i> 61: 2 158-159<br/>

http://publicationslist.org/d.lison/refid104 2010-11-13T08:46:46Z

On the basis of studies of the prevalence of skin cancer among users of As-rich well water in Taiwan, WHO experts recommended in 1984 a maximum As concentration of 50 microg/litre in drinking water. Since that time, a plethora of non-cancer as well as cancer effects has been observed in several other populations sustaining a chronic exposure to various As concentrations in drinking water. This pro...<br/><br/>J Buchet, D Lison (2000) <i>Food Chem Toxicol</i> <i></i> <i></i> 38: 1 Suppl S81-S85<br/>

http://publicationslist.org/d.lison/refid102 2010-11-13T08:46:46Z

OBJECTIVES: To assess occupational exposure to inorganic germanium (Ge) in workers from a producing plant, and to assess the health of these workers, with a special focus on respiratory, kidney, and liver functions. METHODS: Cross sectional study of 75 workers exposed to Ge and 79 matched referents. Exposure was characterised by measuring air and urine concentrations of the element during a typica...<br/><br/>B Swennen, A Mallants, H A Roels, J P Buchet, A Bernard, R R Lauwerys, D Lison (2000) <i>Occup Environ Med</i> <i></i> <i></i> 57: 4 242-248<br/>

http://publicationslist.org/d.lison/refid100 2010-11-13T08:46:46Z

De Boeck M, Lardau, Buchet, Kirsch-Volders, Lison (2000) <i>Environ Mol Mutagen</i> <i></i> <i></i> 36: 2 <br/>

http://publicationslist.org/d.lison/refid101 2010-11-13T08:46:46Z

Mortality studies have shown that, in the past, lung cancer occurred after exposure to mixtures of cobalt metal and metallic carbide particles, the main constituents of hard metals, but apparently not when exposure was to cobalt alone. The major objective of this biomonitoring study was to assess genotoxic effects as a measure for carcinogenic risk in workers from cobalt refineries and hard metal ...<br/><br/>M De Boeck, S Lardau, J P Buchet, M Kirsch-Volders, D Lison (2000) <i>Environ Mol Mutagen</i> <i></i> <i></i> 36: 2 151-160<br/>

http://publicationslist.org/d.lison/refid99 2010-11-13T08:46:46Z

D Lison (2000) <i>Toxicol Appl Pharmacol</i> <i></i> <i></i> 168: 2 173-174<br/>

http://publicationslist.org/d.lison/refid113 2010-11-13T08:46:46Z

Interleukin (IL)-12 is a cytokine produced principally by activated macrophages which is involved in control of the T-helper 1/T-helper 2 cell (Th1/Th2) polarization of immune responses. To examine its potential involvement in the development of lung fibrosis, we examined the expression (protein, messenger RNA [mRNA]) of IL-12 (p70) and of its subunits (p40 and p35) in lung homogenates, bronchoalv...<br/><br/>F Huaux, C Lardot, M Arras, M Delos, M C Many, J P Coutelier, J P Buchet, J C Renauld, D Lison (1999) <i>Am J Respir Cell Mol Biol</i> <i></i> <i></i> 20: 4 561-572<br/>

http://publicationslist.org/d.lison/refid112 2010-11-13T08:46:46Z

We have found reduced activity of tumor necrosis factor (TNF)-alpha accompanying resolving and fibrosing alveolitis induced in NMRI mice by mineral particles (MnO2 and SiO2, respectively), which is in apparent contradiction to the well-recognized proinflammatory and profibrotic activities of this cytokine. The objective of this study was to examine the mechanisms involved in this paradoxical respo...<br/><br/>F Huaux, M Arras, A Vink, J C Renauld, D Lison (1999) <i>Am J Respir Cell Mol Biol</i> <i></i> <i></i> 21: 1 137-145<br/>

http://publicationslist.org/d.lison/refid114 2010-11-13T08:46:46Z

The objective of this study was to assess the effect of two arsenic-containing particles, coal fly ash (FA) and copper smelter dust (CU), on lung integrity and on the ex vivo release of tumor necrosis factor alpha (TNF-alpha) by alveolar phagocytes. Particle effects were compared in nonoverload condition on the basis of a low but identical volume load and arsenic content intratracheally instilled ...<br/><br/>F Broeckaert, J P Buchet, M Delos, J W Yager, D Lison (1999) <i>J Toxicol Environ Health A</i> <i></i> <i></i> 56: 5 343-360<br/>

http://publicationslist.org/d.lison/refid116 2010-11-13T08:46:46Z

BACKGROUND: On March 21, 1998, the Regional Health Authority of Bobo-Dioulasso, Burkina Faso, asked the Centre Muraz to investigate an unexplained outbreak of epidemic fatal encephalopathy (EFE). We aimed to identify the cause of this epidemic. METHODS: We identified cases retrospectively through review of health-service records and interviews of family members, village chiefs, and local healers. ...<br/><br/>H A Meda, B Diallo, J P Buchet, D Lison, H Barennes, A Ouangré, M Sanou, S Cousens, F Tall, P Van de Perre (1999) <i>Lancet</i> <i></i> <i></i> 353: 9152 536-540<br/>

http://publicationslist.org/d.lison/refid110 2010-11-13T08:46:46Z

B Nemery, B Fischler, M Boogaerts, D Lison (1999) <i>Lancet</i> <i></i> <i></i> 354: 9172 <br/>

http://publicationslist.org/d.lison/refid115 2010-11-13T08:46:46Z

Uncovering the exact cause of polyneuropathies seems to be impossible in up to 24% of the cases. Experimental studies have shown that cadmium (Cd), which is a well-known occupational and environmental hazard, can be a potent neurotoxicant for the peripheral nervous system. Moreover, Cd has a half-life of more than 15 years in humans. We hypothesize that older workers may be more susceptible to an ...<br/><br/>M K Viaene, H A Roels, J Leenders, M De Groof, L J Swerts, D Lison, R Masschelein (1999) <i>Neurotoxicology</i> <i></i> <i></i> 20: 1 7-16<br/>

http://publicationslist.org/d.lison/refid111 2010-11-13T08:46:46Z

In 1987, a cross-sectional study in a dry-alkaline battery plant in Belgium revealed subclinical neurobehavioral dysfunctions associated with inhalation exposure to manganese dioxide (MnO2) particulate. The overall geometric mean of the time-weighted average concentration of manganese (Mn) in "total" dust (MnT) amounted, at that time, to 1 mg Mn/m3 and the duration of exposure was 5.5 years on ave...<br/><br/>H A Roels, M I Ortega Eslava, E Ceulemans, A Robert, D Lison (1999) <i>Neurotoxicology</i> <i></i> <i></i> 20: 2-3 255-271<br/>

http://publicationslist.org/d.lison/refid106 2010-11-13T08:46:46Z

BACKGROUND: The clinical relevance of renal effects of cadmium in people exposed in the environment remains uncertain. This study examined the evolution of renal effects observed in a population exposed to cadmium in the environment. METHODS: 208 men and 385 women surveyed in 1985-89 (Cadmium in Belgium study [Cadmibel]; baseline) were re-examined on average 5 years later (Public health and enviro...<br/><br/>P Hotz, J P Buchet, A Bernard, D Lison, R Lauwerys (1999) <i>Lancet</i> <i></i> <i></i> 354: 9189 1508-1513<br/>

http://publicationslist.org/d.lison/refid107 2010-11-13T08:46:46Z

A detailed characterisation of the biotransformation pathways followed by the chemical of interest is, evidently, of primordial importance to design reliable biomonitoring programs. This short overview discusses some recent studies that are of potential interest for the development of new avenues of research. Four topics are addressed: tissue localisation of the metabolic process; importance of sp...<br/><br/>D Lison (1999) <i>Toxicol Lett</i> <i></i> <i></i> 108: 2-3 91-97<br/>

http://publicationslist.org/d.lison/refid105 2010-11-13T08:46:46Z

Although the morphological description of sulfur mustard (SM) injury is well characterised, little is known of the molecular mediators involved in cutaneous toxicity. Since infiltration by lymphocytes and PMNs represents one of the very first events observed in vivo upon exposure to SM, this study examined whether SM exposure can modify the expression by cultured human keratinocytes of interleukin...<br/><br/>C Lardot, V Dubois, D Lison (1999) <i>Toxicol Lett</i> <i></i> <i></i> 110: 1-2 29-33<br/>

http://publicationslist.org/d.lison/refid108 2010-11-13T08:46:46Z

A fibrogenic sample of cristobalite dust, CRIS (crystalline silica of mineral origin), was heated to 1300 degrees C (CRIS-1300) to relate induced physicochemical modifications to cytotoxicity. Heating did not affect dust micromorphology and crystallinity, except for limited sintering and decreased surface area of CRIS-1300. Thermal treatments deeply affected surface properties. Electron paramagnet...<br/><br/>B Fubini, G Zanetti, S Altilia, R Tiozzo, D Lison, U Saffiotti (1999) <i>Chem Res Toxicol</i> <i></i> <i></i> 12: 8 737-745<br/>

http://publicationslist.org/d.lison/refid109 2010-11-13T08:46:46Z

A successful prevention of renal diseases induced by occupational or environmental exposure to toxic metals such as mercury (Hg), lead (Pb), or cadmium (Cd) largely relies on the capability to detect nephrotoxic effects at a stage when they are still reversible or at least not yet compromising renal function. The knowledge of dose-effect/response relations has been useful to control nephrotoxic ef...<br/><br/>H A Roels, P Hoet, D Lison (1999) <i>Ren Fail</i> <i></i> <i></i> 21: 3-4 251-262<br/>

http://publicationslist.org/d.lison/refid124 2010-11-13T08:46:47Z

A minireview is presented concerning the use of cotinine as a tobacco-smoke exposure index. First, general considerations about methods for the determination of urinary cotinine are presented. Besides pure analytical aspects, this minireview considers major problems encountered in the establishment of threshold values that can be used to distinguish not only smokers from nonsmokers but also nonsmo...<br/><br/>V Haufroid, D Lison (1998) <i>Int Arch Occup Environ Health</i> <i></i> <i></i> 71: 3 162-168<br/>

http://publicationslist.org/d.lison/refid123 2010-11-13T08:46:47Z

Altered expression of plasminogen activator inhibitors (PAIs) is of potential relevance to the process of lung fibrosis. To clarify the involvement of PAIs in interstitial lung diseases, we examined whether alterations in PAI-1 and PAI-2 were induced in response to a single intratracheal administration of a fibrosing dose of crystalline silica in mice (5 mg x animal(-1)). The time course of change...<br/><br/>C Lardot, M Heusterpreute, P Mertens, M Philippe, D Lison (1998) <i>Eur Respir J</i> <i></i> <i></i> 11: 4 912-921<br/>

http://publicationslist.org/d.lison/refid125 2010-11-13T08:46:47Z

OBJECT: The dose-response relationship for lung carcinoma and other cancers at low doses of As is highly uncertain because it is based on modeling data collected in populations with a high daily intake of the element. The finding of a slightly increased exposure to arsenic in certain groups of the Belgian general population prompted us to examine whether this had repercussions on the causes of mor...<br/><br/>J P Buchet, D Lison (1998) <i>Int Arch Occup Environ Health</i> <i></i> <i></i> 71: 2 125-130<br/>

http://publicationslist.org/d.lison/refid127 2010-11-13T08:46:47Z

There is evidence that, following exposure to crystalline silica, the release of several proinflammatory cytokines contributes to the induction of unbalanced inflammatory reaction leading to lung fibrosis. We have examined the potential contribution of interleukin-10 (IL-10), an anti-inflammatory cytokine, in the development of silicosis. In a mouse model of inflammatory lung reaction induced by i...<br/><br/>F Huaux, J Louahed, B Hudspith, C Meredith, M Delos, J C Renauld, D Lison (1998) <i>Am J Respir Cell Mol Biol</i> <i></i> <i></i> 18: 1 51-59<br/>

http://publicationslist.org/d.lison/refid122 2010-11-13T08:46:47Z

Impaired fibrinolytic activity and persistent fibrin deposits in lung tissue have been associated with lung fibrotic disorders. The present study examined the sources of plaminogen activator (PA) changes induced by a single intratracheal administration of silica particles (5 mg) in the mouse lung. We found in both control and silica-treated animals that amiloride almost totally abolished PA activi...<br/><br/>C Lardot, M Delos, D Lison (1998) <i>Am J Physiol</i> <i></i> <i></i> 274: 6 Pt 1 L1040-L1048<br/>

http://publicationslist.org/d.lison/refid126 2010-11-13T08:46:47Z

The lung plasminogen activator (PA) response was examined in four different models of particle-induced pulmonary lesions in NMRI mice (single intratracheal administration, 0.75 to 5 mg/mouse). Sequential changes in cellular (total and differential counts) and biochemical markers of alveolitis (lactate dehydrogenase [LDH], total proteins) were monitored in bronchoalveolar fluid (BALF) and the fibro...<br/><br/>C G Lardot, F A Huaux, F R Broeckaert, P J Declerck, M Delos, B Fubini, D F Lison (1998) <i>Am J Respir Crit Care Med</i> <i></i> <i></i> 157: 2 617-628<br/>

http://publicationslist.org/d.lison/refid121 2010-11-13T08:46:47Z

P Y Van den Bergh, D F Lison (1998) <i>Adv Neurol</i> <i></i> <i></i> 78: 231-235<br/>

http://publicationslist.org/d.lison/refid118 2010-11-13T08:46:46Z

The mechanisms of cobalt-induced pulmonary interstitial fibrosis and cancer are incompletely understood. DNA damage, either induced by genotoxic (direct or via oxygen radicals) or co-genotoxic (e.g. inhibition of DNA repair) processes may play an important role in the initiation of cancer. The alkaline comet assay provides a sensitive tool to investigate these two processes. Cobalt metal, a mixtur...<br/><br/>M De Boeck, D Lison, M Kirsch-Volders (1998) <i>Carcinogenesis</i> <i></i> <i></i> 19: 11 2021-2029<br/>

http://publicationslist.org/d.lison/refid119 2010-11-13T08:46:46Z

Since tumor growth factor beta (TGF-beta) and its receptor are ubiquitously expressed and because latent TGF-beta cannot bind to the cell surface receptor, the ability of a cell to activate latent TGF-beta upon secretion represents an important regulatory mechanism of TGF-beta action. In vivo, the protease plasmin is considered to be one of the main enzymes operative in the proteolytic cleavage of...<br/><br/>M Matrat, C Lardot, F Huaux, F Broeckaert, D Lison (1998) <i>J Toxicol Environ Health A</i> <i></i> <i></i> 55: 5 359-371<br/>

http://publicationslist.org/d.lison/refid117 2010-11-13T08:46:46Z

Many organisms can easily dispose of toxic inorganic arsenic species through gradual methylation of the element and further urinary excretion. In order to clarify the urinary excretion of arsenobetaine observed in a human case of intoxication by arsine, the capacity of highly methylated arsenical synthesis has been investigated in rats acutely exposed during 1 h to increasing concentrations of the...<br/><br/>J P Buchet, P Apostoli, D Lison (1998) <i>Arch Toxicol</i> <i></i> <i></i> 72: 11 706-710<br/>

http://publicationslist.org/d.lison/refid120 2010-11-13T08:46:46Z

V Haufroid, A Clippe, B Knoops, A Bernard, D Lison (1998) <i>Clin Chem</i> <i></i> <i></i> 44: 10 2210-2211<br/>

http://publicationslist.org/d.lison/refid134 2010-11-13T08:46:47Z

The objective of this study was to examine the influence of specific surface area on the biological activity of insoluble manganese dioxide (MnO2) particles. The biological responses to various MnO2 dusts with different specific surface area (0.16, 0.5, 17 and 62 m2/g) were compared in vitro and in vivo. A mouse peritoneal macrophage model was used to evaluate the in vitro cytotoxic potential of t...<br/><br/>D Lison, C Lardot, F Huaux, G Zanetti, B Fubini (1997) <i>Arch Toxicol</i> <i></i> <i></i> 71: 12 725-729<br/>

http://publicationslist.org/d.lison/refid135 2010-11-13T08:46:47Z

OBJECTIVES: (1) To assess the value of urinary butoxyacetic acid (BAA) measurement for the monitoring of workers exposed to low concentration of 2-butoxyethanol (BE); (2) to evaluate the in vivo effect of low occupational BE exposure on the erythrocyte lineage; and (3) to test the possible influence of genetic polymorphism for cytochrome P450 2E1 (CYP 2E1) on urinary BAA excretion rate. METHODS: T...<br/><br/>V Haufroid, F Thirion, P Mertens, J P Buchet, D Lison (1997) <i>Int Arch Occup Environ Health</i> <i></i> <i></i> 70: 4 232-236<br/>

http://publicationslist.org/d.lison/refid138 2010-11-13T08:46:47Z

Hard metals (WC-Co) are made of a mixture of cobalt metal (Co, 5-10%) and tungsten carbide particles (WC, >80%). Excessive inhalation of WC-Co is associated with the occurrence of different lung diseases including an excess of lung cancers. The elective toxicity of hard metal is based on a physico-chemical interaction between cobalt metal and tungsten carbide particles to produce activated oxygen ...<br/><br/>D Anard, M Kirsch-Volders, A Elhajouji, K Belpaeme, D Lison (1997) <i>Carcinogenesis</i> <i></i> <i></i> 18: 1 177-184<br/>

http://publicationslist.org/d.lison/refid133 2010-11-13T08:46:47Z

D Lison, J P Buchet, P Hoet (1997) <i>Lancet</i> <i></i> <i></i> 349: 9044 58-59<br/>

http://publicationslist.org/d.lison/refid136 2010-11-13T08:46:47Z

The expression of plasminogen activator (PA), a serine proteinase involved in the degradation of extracellular matrix proteins, has been investigated in 3T3 fibroblasts after in vitro exposure to sulphur mustard (SM). Expression of the cell-associated enzyme has been assessed with a synthetic substrate assay and at the mRNA level. Twenty-four hours after 100 microM SM, cell viability (monitored by...<br/><br/>M Detheux, H Jijakli, D Lison (1997) <i>Arch Toxicol</i> <i></i> <i></i> 71: 4 243-249<br/>

http://publicationslist.org/d.lison/refid137 2010-11-13T08:46:47Z

The absorption and cerebral distribution of manganese (Mn) have been studied with respect to the route of administration and the chemical form of the Mn compound. Different groups of adult male rats received either MnCl2, 4H2O or MnO2 once a week for 4 weeks at a dose of 24.3 mg Mn/kg body wt. (b.w.) by oral gavage (g.) or 1.22 mg Mn/kg b.w. by intraperitoneal injection (i.p.) or intratracheal ins...<br/><br/>H Roels, G Meiers, M Delos, I Ortega, R Lauwerys, J P Buchet, D Lison (1997) <i>Arch Toxicol</i> <i></i> <i></i> 71: 4 223-230<br/>

http://publicationslist.org/d.lison/refid128 2010-11-13T08:46:47Z

BACKGROUND: Hydrochlorofluorocarbons (HCFCs) are used increasingly in industry as substitutes for ozone-depleting chlorofluorocarbons (CFCs). Limited studies in animals indicate potential hepatotoxicity of some of these compounds. We investigated an epidemic of liver disease in nine industrial workers who had had repeated accidental exposure to a mixture of 1,1-dichloro-2,2,2-trifluoroethane (HCFC...<br/><br/>P Hoet, M L Graf, M Bourdi, L R Pohl, P H Duray, W Chen, R M Peter, S D Nelson, N Verlinden, D Lison (1997) <i>Lancet</i> <i></i> <i></i> 350: 9077 556-559<br/>

http://publicationslist.org/d.lison/refid129 2010-11-13T08:46:47Z

Although it is well known that micronuclei may arise from either DNA breakage leading to acentric chromosome fragments or from chromosome/chromatid lagging in anaphase, the ratio between the amount of DNA breakage induced and the frequency of micronuclei expressed in the following interphase is unclear. With the development of the alkaline single cell gel electrophoresis assay, which measures sing...<br/><br/>F Van Goethem, D Lison, M Kirsch-Volders (1997) <i>Mutat Res</i> <i></i> <i></i> 392: 1-2 31-43<br/>

http://publicationslist.org/d.lison/refid132 2010-11-13T08:46:47Z

The study aimed at assessing the evolution of cadmium (Cd)-induced renal tubular dysfunction in Cd workers according to the severity of the microproteinuria observed at the time the exposure was substantially decreased. Male workers employed in the Cd production industry for whom formerly high exposure had markedly decreased by 1984 and for whom standardized medical data were available during two ...<br/><br/>H A Roels, F J Van Assche, M Oversteyns, M De Groof, R R Lauwerys, D Lison (1997) <i>Am J Ind Med</i> <i></i> <i></i> 31: 5 645-652<br/>

http://publicationslist.org/d.lison/refid130 2010-11-13T08:46:47Z

P Hoet, D Lison (1997) <i>Clin Chem</i> <i></i> <i></i> 43: 7 <br/>

http://publicationslist.org/d.lison/refid131 2010-11-13T08:46:47Z

We investigated the effect of intratracheally instilled coal fly ash (FA) and copper smelter dust (CU) on the lung integrity and on the ex vivo release of tumor necrosis factor alpha (TNF-alpha) by alveolar phagocytes. Groups of female NMRI mice received a single intratracheal administration of different particles normalized for the arsenic content (20 micrograms/kg body weight, i.e., 600 ng arsen...<br/><br/>F Broeckaert, J P Buchet, F Huaux, C Lardot, D Lison, J W Yager (1997) <i>J Toxicol Environ Health</i> <i></i> <i></i> 51: 2 189-202<br/>

http://publicationslist.org/d.lison/refid143 2010-11-13T08:46:47Z

Enhancement of lung antioxidant capacity has been proposed in the therapy of acute lung injuries involving local accumulation of reactive oxygen species (ROS). We have studied in the female Sprague-Dawley rat the effect of intratracheal administration of catalase (CAT) on the acute lung response induced by different ROS generating systems. The lung response was assessed at several time intervals (...<br/><br/>C Lardot, F Broeckaert, D Lison, J P Buchet, R Lauwerys (1996) <i>J Toxicol Environ Health</i> <i></i> <i></i> 47: 6 509-522<br/>

http://publicationslist.org/d.lison/refid144 2010-11-13T08:46:47Z

The aim of this study is to assess the ability of three methods, alkaline elution (AE), nick translation (NT), and single-cell gel electrophoresis (SCGE), to detect DNA single-strand breaks (ssb) in human peripheral blood lymphocytes (HPBL) exposed in vitro to three genotoxic agents; gamma-rays, ethyl methanesulfonate (EMS) and benzo[a]pyrene diol epoxide (BPDE). The ultimate objective is to selec...<br/><br/>T Leroy, P Van Hummelen, D Anard, P Castelain, M Kirsch-Volders, R Lauwerys, D Lison (1996) <i>J Toxicol Environ Health</i> <i></i> <i></i> 47: 5 409-422<br/>

http://publicationslist.org/d.lison/refid145 2010-11-13T08:46:47Z

Occupational medicine and occupational health regulations in Belgium are succinctly presented. Since 1970 a minimum level of appropriate training has been required for conferral of a certificate in occupational medicine. At some universities this training is integrated into a larger programme which meets the requirements of EEC Directive 89/594. The current Belgian legislation relating to the prev...<br/><br/>P Hoet, D Lison (1996) <i>Int Arch Occup Environ Health</i> <i></i> <i></i> 68: 3 137-140<br/>

http://publicationslist.org/d.lison/refid142 2010-11-13T08:46:47Z

The etiology of male infertilities is largely undetermined, and our knowledge of exogenous factors affecting the male reproductive system is still limited. In particular, the role of specific environmental and occupational factors is incompletely elucidated. Various occupational (physical and chemical) agents have been shown to affect male reproductive functions in animals, but large differences i...<br/><br/>S Tas, R Lauwerys, D Lison (1996) <i>Crit Rev Toxicol</i> <i></i> <i></i> 26: 3 261-307<br/>

http://publicationslist.org/d.lison/refid146 2010-11-13T08:46:47Z

To assess whether regular consumption of seafood, particularly fish and shellfish, by humans may lead to an overexposure to inorganic arsenic, a well-established human carcinogen, the urinary excretion of the relevant As metabolites (Asi, inorganic form; MMA, monomethylarsonic acid; DMA, dimethylarsinic acid) was compared in groups of subjects with different seafood consumption habits and in volun...<br/><br/>J P Buchet, D Lison, M Ruggeri, V Foa, G Elia (1996) <i>Arch Toxicol</i> <i></i> <i></i> 70: 11 773-778<br/>

http://publicationslist.org/d.lison/refid141 2010-11-13T08:46:47Z

In recent years, epidemiological evidence that exposure to toluene diisocyanate (TDI) is associated with adverse health effects has led to the development of useful analytical methods for the biological monitoring of TDI. In this paper, an HPLC method is presented that allows accurate determinations of toluenediamines (TDA), urinary metabolites of TDI, in hydrolysed human urine without complicated...<br/><br/>P Carbonnelle, S Boukortt, D Lison, J P Buchet (1996) <i>Analyst</i> <i></i> <i></i> 121: 5 663-669<br/>

http://publicationslist.org/d.lison/refid139 2010-11-13T08:46:47Z

In the industry, the potential for exposure to cobalt metal dust is particularly important during the production of cobalt powder and the processing and use of hard metals and other cobalt-containing alloys. The different adverse health effects reported in these workers are reviewed. One of the main target organs is the respiratory tract, and this article concentrates on the lung parenchymal react...<br/><br/>D Lison (1996) <i>Crit Rev Toxicol</i> <i></i> <i></i> 26: 6 585-616<br/>

http://publicationslist.org/d.lison/refid140 2010-11-13T08:46:47Z

In recent years clinical, epidemiological and experimental evidence has accumulated indicating that cobalt metal particles, when inhaled in association with other agents such as metallic carbides (hard metals) or diamond dust, may produce an interstitial lung disease termed "hard metal disease" or "cobalt lung". This article summarizes the progress accomplished in our two laboratories to understan...<br/><br/>D Lison, R Lauwerys, M Demedts, B Nemery (1996) <i>Eur Respir J</i> <i></i> <i></i> 9: 5 1024-1028<br/>

http://publicationslist.org/d.lison/refid152 2010-11-13T08:46:47Z

Decreased interleukin-1 (IL-1) production by mononuclear phagocytes has been shown to contribute to benzene myelotoxicity in animals. The study presented here was designed to examine the relevance of this mechanism in humans. Fresh human blood monocytes were exposed to 0.001-10 microM hydroquinone (HQ) and assessed for their ability to release IL-1 alpha and IL-1 beta in response to a stimulation ...<br/><br/>P Carbonnelle, D Lison, J Y Leroy, R Lauwerys (1995) <i>Toxicol Appl Pharmacol</i> <i></i> <i></i> 132: 2 220-226<br/>

http://publicationslist.org/d.lison/refid153 2010-11-13T08:46:47Z

Epidemiological and clinical studies suggest that inhalation of cobalt metal dust (Co) mixed with tungsten carbide particles (WC), but not of cobalt dust alone, may cause interstitial pulmonary lesions (hard metal disease). In previous experimental studies in the rat, we have demonstrated the greater acute pulmonary toxicity of a WC-Co mixture compared to Co or WC alone. The present study was unde...<br/><br/>G Lasfargues, C Lardot, M Delos, R Lauwerys, D Lison (1995) <i>Environ Res</i> <i></i> <i></i> 69: 2 108-121<br/>

http://publicationslist.org/d.lison/refid156 2010-11-13T08:46:47Z

1. Pyridostigmine (PYR) pretreatment is used by the military to obtain 20-30% whole blood acetylcholinesterase (AChE) inhibition in order to enhance the effectiveness of the standard therapeutic regimen for poisoning by an organophosphate anticholinesterase agent. The present study was undertaken to investigate in a rat model the potential muscle damage produced by this pretreatment when given alo...<br/><br/>M Hubert, D Lison (1995) <i>Hum Exp Toxicol</i> <i></i> <i></i> 14: 1 49-54<br/>

http://publicationslist.org/d.lison/refid155 2010-11-13T08:46:47Z

1. This in vitro study was undertaken as a preliminary approach before assessing whether the alkaline elution assay can be applied to peripheral blood lymphocytes (PBL) for the monitoring of humans exposed to genotoxic agents such as polycyclic aromatic hydrocarbons (PAH). We have compared in vitro, with the aid of the alkaline elution assay, the formation and the repair of DNA single-strand break...<br/><br/>T Leroy, D Lison, R Lauwerys (1995) <i>Hum Exp Toxicol</i> <i></i> <i></i> 14: 1 61-68<br/>

http://publicationslist.org/d.lison/refid154 2010-11-13T08:46:47Z

Hard metal alloys (WC-Co) are made of a mixture of cobalt (Co; 6%) and tungsten carbide (WC; 94%) particles. Chronic inhalation of hard metal dust can lead to the development of a fibrosing alveolitis, the pathogenesis of which is still undefined. The present investigation was undertaken to assess the effect of Co, WC, and WC-Co particles on the release by lung phagocytes of interleukin-1 (IL-1), ...<br/><br/>F Huaux, G Lasfargues, R Lauwerys, D Lison (1995) <i>Toxicol Appl Pharmacol</i> <i></i> <i></i> 132: 1 53-62<br/>

http://publicationslist.org/d.lison/refid151 2010-11-13T08:46:47Z

Hard metal alloys (or cemented carbides) are made of a mixture of tungsten carbide particles (WC, more than 80%) cemented in cobalt metal powder (Co, 5-10%). The inhalation of hard metal particles may cause an interstitial pulmonary disease, the mechanism of which involves an interaction between Co and WC particles. Some epidemiological data also suggest that hard metal dust can induce lung cancer...<br/><br/>D Lison, P Carbonnelle, L Mollo, R Lauwerys, B Fubini (1995) <i>Chem Res Toxicol</i> <i></i> <i></i> 8: 4 600-606<br/>

http://publicationslist.org/d.lison/refid150 2010-11-13T08:46:47Z

Chronic inhalation of hard metal particles can produce an interstitial lung disease (hard metal disease). Recent studies on rats and on isolated alveolar and peritoneal macrophages have demonstrated that this disorder can be explained by an interaction between cobalt metal (Co) and tungsten carbide (WC) particles, which represent the main constituents of hard metal. The exact mechanism of this int...<br/><br/>D Lison, R Lauwerys (1995) <i>Toxicol In Vitro</i> <i></i> <i></i> 9: 3 341-347<br/>

http://publicationslist.org/d.lison/refid148 2010-11-13T08:46:47Z

The oxygen dependence of ethane formation was investigated in rat lung and liver homogenates, incubated in sealed flasks, in which the peroxidation was stimulated by the addition of ferrous ions. For both tissues, the production of ethane was maximal under a 20% oxygenated gas phase, while hyperoxic conditions led to a decreased ethane in the gas phase. The formation of thiobarbituric acid-reactiv...<br/><br/>M D Schweich, J Gosselain, D Lison, R Lauwerys (1995) <i>J Toxicol Environ Health</i> <i></i> <i></i> 46: 1 23-29<br/>

http://publicationslist.org/d.lison/refid147 2010-11-13T08:46:47Z

D Lison (1995) <i>Hum Exp Toxicol</i> <i></i> <i></i> 14: 10 854-855<br/>

http://publicationslist.org/d.lison/refid149 2010-11-13T08:46:47Z

The production of thiobarbituric acid-reactive substances (TBA-RS) and ethane, two markers of the lipid peroxidation process, was evaluated in rat lung and liver microsomal membranes incubated in the presence of either ferrous ions or a mixture of ferric ions and ascorbate. Microsomal fractions isolated from lung tissue were more resistant than those isolated from the liver. Compared to Fe2+, the ...<br/><br/>M D Schweich, D Lison, R Lauwerys (1995) <i>Environ Res</i> <i></i> <i></i> 70: 1 62-69<br/>

http://publicationslist.org/d.lison/refid161 2010-11-13T08:46:47Z

The effect of the vesicating agent sulfur mustard (SM) has been investigated in vitro using murine peritoneal macrophages. The rationale for this study was three-fold: (1) the first symptoms after exposure to SM are mucous and cutaneous erythema, itching and oedema suggesting that inflammatory cells may represent an early target of SM toxicity; (2) it has been proposed that macrophages and their s...<br/><br/>E Pilatte, D Lison (1994) <i>Toxicol In Vitro</i> <i></i> <i></i> 8: 1 125-130<br/>

http://publicationslist.org/d.lison/refid162 2010-11-13T08:46:47Z

The intermediate syndrome in organophosphate poisoning is clinically characterized by weakness in the territory of cranial nerves, weakness of respiratory, neck and proximal limb muscles, and depressed deep tendon reflexes. It occurs between the acute cholinergic crisis and the usual onset of organophosphate-induced delayed neurotoxicity. The weakness has been ascribed to muscle fiber necrosis. Fe...<br/><br/>J De Bleecker, D Lison, K Van Den Abeele, J Willems, J De Reuck (1994) <i>Neurotoxicology</i> <i></i> <i></i> 15: 2 341-348<br/>

http://publicationslist.org/d.lison/refid163 2010-11-13T08:46:47Z

Hard metal is an alloy of tungsten carbide (WC) in a matrix of cobalt metal (Co). The inhalation of hard metal dust can cause an alveolitis which may progress to interstitial fibrosis. This study was undertaken to compare, both in vivo and in vitro, the bioavailability of cobalt metal when mixed or not with WC and to assess whether this factor had any influence on the cellular toxicity of hard met...<br/><br/>D Lison, R Lauwerys (1994) <i>Arch Toxicol</i> <i></i> <i></i> 68: 8 528-531<br/>

http://publicationslist.org/d.lison/refid160 2010-11-13T08:46:47Z

We report a case of organophosphate poisoning with a commercial preparation of malathion (deliberate ingestion of Malathane Garden Spray: malathion 15% in isopropyl alcohol) in which the initial cholinergic crisis was followed by cardiac, pulmonary, neurological and renal manifestations. They occurred when erythrocyte and plasma cholinesterases were reactivating. A chemical analysis of the pestici...<br/><br/>A Dive, P Mahieu, R Van Binst, A Hassoun, D Lison, H De Bisschop, B Nemery, R Lauwerys (1994) <i>Hum Exp Toxicol</i> <i></i> <i></i> 13: 4 271-274<br/>

http://publicationslist.org/d.lison/refid157 2010-11-13T08:46:47Z

OBJECTIVE: The aim was to examine the relation between environmental and biological (blood and urine) indices of exposure to different chemical forms of cobalt. METHODS: A cross sectional study was undertaken in workers exposed to cobalt metal, oxides, and salts in a refinery and to a mixture of cobalt and tungsten carbide in a hard metal producing plant. RESULTS AND CONCLUSION: Although biologica...<br/><br/>D Lison, J P Buchet, B Swennen, J Molders, R Lauwerys (1994) <i>Occup Environ Med</i> <i></i> <i></i> 51: 7 447-450<br/>

http://publicationslist.org/d.lison/refid159 2010-11-13T08:46:47Z

The lung thiobarbituric acid-reactive substances (TBA-RS) content and the amount of ethane exhaled, two potential markers of the lipid peroxidation process, were measured in rats following intratracheal administration of chemicals stimulating the production of free radicals, i.e. paraquat, phorbol myristate acetate and ferrous ions. Five hours after treatment, autopsy revealed gross pulmonary dama...<br/><br/>M D Schweich, D Lison, R Lauwerys (1994) <i>Biochem Pharmacol</i> <i></i> <i></i> 47: 8 1395-1400<br/>

http://publicationslist.org/d.lison/refid158 2010-11-13T08:46:47Z

Cobalt is an essential oligoelement which enters in the composition of vitamin B12. For the general population, food and beverages represent the main source of cobalt exposure. Traces of cobalt are also present in cement and various household products. In industry, the potential for exposure to cobalt is particularly important during the production of cobalt powder, the production, processing and ...<br/><br/>R Lauwerys, D Lison (1994) <i>Sci Total Environ</i> <i></i> <i></i> 150: 1-3 1-6<br/>

http://publicationslist.org/d.lison/refid168 2010-11-13T08:46:47Z

The lung toxicity of a carbide-cobalt mixture is more important than that of each individual component; the mechanism of this interaction is not understood. The capacity of cobalt metal particles alone and mixed with different carbides to generate hydroxyl radicals was examined with the deoxyribose assay. In a chemical system, cobalt ions and cobalt metal particles (Co) were found to catalyse the ...<br/><br/>D Lison, R Lauwerys (1993) <i>Arch Toxicol</i> <i></i> <i></i> 67: 5 347-351<br/>

http://publicationslist.org/d.lison/refid167 2010-11-13T08:46:47Z

Mature spermatozoa contain a number of proteases that are supposed to contribute to their fertilizing ability. The present study was directed at plasminogen activator (PA), a protease that belongs to the group of serine proteases and converts the zymogen plasminogen to the active broad-spectrum protease plasmin. To investigate the possible role of PA in the fertilization process, we have measured ...<br/><br/>D Lison, S Tas, J P Gennart, I Psalti, S De Cooman, R Lauwerys (1993) <i>Int J Androl</i> <i></i> <i></i> 16: 3 201-206<br/>

http://publicationslist.org/d.lison/refid166 2010-11-13T08:46:47Z

1. This study was initiated to ascertain the possibility of biochemically monitoring the rhabdomyonecrosis that occurs after organophosphate poisoning. The evolution of different parameters has been assessed in the rat 6, 16, 24 and 48 h following 0.67 x LD50 of soman. 2. Acetylcholinesterase (AChE) was inhibited to 60% of the control value in the diaphragm at 6 and 16 h and serum ChE levels inhib...<br/><br/>Y Vanneste, D Lison (1993) <i>Hum Exp Toxicol</i> <i></i> <i></i> 12: 5 365-370<br/>

http://publicationslist.org/d.lison/refid164 2010-11-13T08:46:47Z

Plasminogen activator (PA) activity has been suggested to be an important determinant of cell migration and tissue modelling during organogenesis. We have postulated that in the developing embryo, any abnormal modulation of this enzymatic activity may lead to the production of teratogenic effects. In the present study, we investigated the effect of teratogenic doses (inducing about 50% of malforme...<br/><br/>D Lison, G Van Maele-Fabry, F Gofflot, J J Picard, R Lauwerys (1993) <i>Toxicol In Vitro</i> <i></i> <i></i> 7: 6 751-755<br/>

http://publicationslist.org/d.lison/refid165 2010-11-13T08:46:47Z

Several organs (lung, skin, thyroid, heart, bone marrow) are potential targets of cobalt (Co). Whereas there is no doubt that inhalation of Co alone may cause bronchial asthma, its role in the occurrence of hard metal disease is still controversial because most cases were reported in workers exposed not only to Co but also to other substances such as tungsten carbide, titanium carbide, iron, silic...<br/><br/>B Swennen, J P Buchet, D Stánescu, D Lison, R Lauwerys (1993) <i>Br J Ind Med</i> <i></i> <i></i> 50: 9 835-842<br/>

http://publicationslist.org/d.lison/refid170 2010-11-13T08:46:47Z

Alveolitis progressing to lung fibrosis has been reported in workers exposed to cobalt containing dust (e.g., tungsten carbide-cobalt mixture as produced by the hard metal industry) but rarely following exposure to pure cobalt dust (e.g., in cobalt-producing factories). We have previously demonstrated that tungsten carbide-cobalt mixture is more toxic toward rat alveolar macrophages in vitro than ...<br/><br/>G Lasfargues, D Lison, P Maldague, R Lauwerys (1992) <i>Toxicol Appl Pharmacol</i> <i></i> <i></i> 112: 1 41-50<br/>

http://publicationslist.org/d.lison/refid169 2010-11-13T08:46:47Z

We have previously demonstrated that tungsten carbide-cobalt powder (WC-Co) is more toxic toward murine macrophages in vitro than pure cobalt metal particles and that the cellular uptake of cobalt is enhanced when the metal is present in the form of WC-Co mixture. The present study was undertaken to assess the possible mechanism(s) of this interaction. We found that solubilization of cobalt in the...<br/><br/>D Lison, R Lauwerys (1992) <i>Toxicol Lett</i> <i></i> <i></i> 60: 2 203-210<br/>

http://publicationslist.org/d.lison/refid174 2010-11-13T08:46:47Z

This study was undertaken to assess whether plasminogen activator (PA) induction in macrophages exposed to chrysotile fibers is mediated by protein kinase C (PKC) activation. In PKC depleted J774 cells, PA induction could be elicited by chrysotile whereas, as expected, the response to phorbol myristate acetate (PMA) was abolished. The effect of PMA and chrysotile on the distribution of PKC activit...<br/><br/>D Lison, F Raguzzi, R Lauwerys (1991) <i>Arch Toxicol</i> <i></i> <i></i> 65: 5 386-389<br/>

http://publicationslist.org/d.lison/refid175 2010-11-13T08:46:47Z

Time and dose dependency of paraoxon-induced myopathy in rats was studied in relation to esterase inhibition and clinical symptoms. High-dose poisoning resulted in a major cholinergic crisis with concomitant acetylcholinesterase inhibition in the first few hours with rapid restoration thereafter. Dose-dependent segmental muscle fiber necrosis occurred in clusters around the end-plates and was more...<br/><br/>J De Bleecker, J Willems, J De Reuck, P Santens, D Lison (1991) <i>Acta Neurol Belg</i> <i></i> <i></i> 91: 5 255-270<br/>

http://publicationslist.org/d.lison/refid173 2010-11-13T08:46:47Z

A previous study from this laboratory, using morphological and biochemical (LDH release) parameters, has shown that tungsten carbide-cobalt dust exhibits a greater cytotoxicity toward isolated macrophages than cobalt metal powder alone. The present study extends this comparison by examining additional biological parameters. Glucose uptake and superoxide anion production by isolated macrophages wer...<br/><br/>D Lison, R Lauwerys (1991) <i>Pharmacol Toxicol</i> <i></i> <i></i> 69: 4 282-285<br/>

http://publicationslist.org/d.lison/refid171 2010-11-13T08:46:47Z

A study was undertaken to assess the importance of systematically recording occupational histories of patients admitted to an internal medicine unit of a university hospital. Detailed information on current and past employment was obtained with questionnaires and in personal interviews from 200 inpatients over a 12-month period. Twenty-one patients (10.5%) were considered to have a "primary illnes...<br/><br/>J P Gennart, P Hoet, D Lison, R Lauwerys, E Coche, M Lambert (1991) <i>Scand J Work Environ Health</i> <i></i> <i></i> 17: 6 386-391<br/>

http://publicationslist.org/d.lison/refid172 2010-11-13T08:46:47Z

The effect on spleen cells of a single in vivo treatment with sulfur mustard was analyzed in mice 1 week after intoxication. A marked decrease in the number of total spleen cells was observed in mice receiving high doses of sulfur mustard. Flow cytometric analysis indicated that B-lymphocytes were relatively more affected than T-lymphocytes by this toxic compound. However, the function of remainin...<br/><br/>J P Coutelier, D Lison, O Simon, J Willems (1991) <i>Toxicol Lett</i> <i></i> <i></i> 58: 2 143-148<br/>

http://publicationslist.org/d.lison/refid179 2010-11-13T08:46:47Z

We report a patient in whom intoxication with a commercial preparation of malathion led to a severe acute cholinergic crisis, protracted cardiac arrhythmias, an acute respiratory distress syndrome, and an acute sensorimotor axonal polyneuropathy. The occurrence of the polyneuropathy was associated with a novel malathion transformation product, S-(1-ethoxycarbonyl, 2-isopropoxycarbonyl) ethyl 0,0-d...<br/><br/>A Monje Argiles, D Lison, R Lauwerys, P Mahieu, J M Brucher, P Van den Bergh (1990) <i>Acta Neurol Belg</i> <i></i> <i></i> 90: 4 190-199<br/>

http://publicationslist.org/d.lison/refid177 2010-11-13T08:46:47Z

"Hard metal disease" is a chronic lung disease characterized by the presence of interstitial fibrosis; the role of cobalt in the development of this entity is still debated. Indeed, most cases have been observed in some workplaces (grinding) of the hard metal industry and in the diamond polishing industry whereas no similar cases have been reported from workers exposed to pure cobalt powders in co...<br/><br/>D Lison, R Lauwerys (1990) <i>Environ Res</i> <i></i> <i></i> 52: 2 187-198<br/>

http://publicationslist.org/d.lison/refid178 2010-11-13T08:46:47Z

Urokinase-type plasminogen activator (uPA) has been implicated in cellular migration accompanying different biological phenomena including organogenesis. An increase in uPA activity was observed in mouse post-implantation embryos during the early organogenesis period. Since we have previously shown that all-trans retinoic acid (RA) prevented the induction of uPA in mouse peritoneal macrophages, we...<br/><br/>B Knoops, D Lison, C Collette, R Lauwerys, J J Picard (1990) <i>Biochem Pharmacol</i> <i></i> <i></i> 39: 10 1545-1548<br/>

http://publicationslist.org/d.lison/refid176 2010-11-13T08:46:47Z

The effect of auranofin (AF), retinoic acid (RA), and three heavy metals reacting with thiol groups (Hg, Cd, Pb) has been compared on a PKC mediated response of intact macrophages (i.e. plasminogen activator (PA) induction) and on purified PKC activity. AF, cadmium chloride, and lead nitrate directly inhibit PKC and hence prevent the induction of PA activity in macrophages stimulated with PMA. In ...<br/><br/>D Lison, F Raguzzi, R Lauwerys (1990) <i>Pharmacol Toxicol</i> <i></i> <i></i> 67: 3 239-242<br/>

http://publicationslist.org/d.lison/refid181 2010-11-13T08:46:47Z

Urokinase-type plasminogen activator, a neutral proteinase, seems to play a central role in the degradation of the extracellular matrix that accompanies a number of biological phenomena including inflammatory reactions and neoplasia. The effect of auranofin and retinoic acid on the plasminogen activator activity expressed by two cell types, i.e. murine macrophages and Lewis lung carcinoma cells, h...<br/><br/>D Lison, B Knoops, C Collette, R Lauwerys (1989) <i>Biochem Pharmacol</i> <i></i> <i></i> 38: 13 2107-2112<br/>

http://publicationslist.org/d.lison/refid180 2010-11-13T08:46:47Z

D Lison, B Knoops, R Lauwerys (1989) <i>Br J Ind Med</i> <i></i> <i></i> 46: 7 496-497<br/>

http://publicationslist.org/d.lison/refid182 2010-11-13T08:46:47Z

Casein-elicited mouse peritoneal macrophages cultured in the presence of phorbol 12-myristate 13-acetate (PMA) express u-PA. Induction is maximal after 4 hr of stimulation and u-PA activity is mainly recovered with the membrane fraction of the cellular lysate. This enzymatic activity is inhibited by isopropylmethylphosphonofluoridate after stimulation by PMA. The presence of the organophosphorus c...<br/><br/>P Dubois, D Lison, R Lauwerys (1988) <i>Biochem Pharmacol</i> <i></i> <i></i> 37: 11 2139-2143<br/>

http://publicationslist.org/d.lison/refid183 2010-11-13T08:46:47Z

The in vitro effects of mercuric chloride and vanadate were examined on two functions of mouse peritoneal macrophages, i.e., the superoxide anion production and the plasminogen activator (PA) activity. Vanadate, at concentrations which do not affect the viability of the cells, does not seriously alter any of these functions. High concentrations of mercury depress the respiratory burst; this effect...<br/><br/>D Lison, P Dubois, R Lauwerys (1988) <i>Toxicol Lett</i> <i></i> <i></i> 40: 1 29-36<br/>