http://publicationslist.org/data/david.goldsmith/atom.xml David Goldsmithhttp://publicationslist.org/david.goldsmith$basepathfavicon.icoRecent additions to David Goldsmith's PublicationsList.org pagehttp://publicationslist.org/publications.png2008-05-11T21:30:10Z http://publicationslist.org/david.goldsmith/refid6 2008-05-11T21:23:14Z

Chronic kidney disease-mineral bone disorder is a common clinical picture encountered in patients with end-stage renal disease and is the result of additive pathophysiological processes. Renal transplantation remains the treatment of choice for these patients, especially as advances in this field have allowed for enhanced allograft survival. However, with increasing success of renal transplantatio...<br/><br/>Hazim Sadideen, Adrian Covic, David Goldsmith (2008) <i>Int Urol Nephrol</i> <i></i> <i></i> 40: 1 171-184<br/>

http://publicationslist.org/david.goldsmith/refid8 2008-05-11T21:23:14Z

The mortality rates which we have seen now over several decades of routine provision of renal replacement therapy are truly remarkable - even if, with time, we have become familiar, if not comfortable, with them. The remarkable nature of this mortality issue is its severity, and persistence, despite numerous efforts to combat it with 'active interventions'. These have included, in no particular or...<br/><br/>David Goldsmith (2008) <i>Blood Purif</i> <i></i> <i></i> 26: 1 63-66<br/>

http://publicationslist.org/david.goldsmith/refid10 2008-05-11T21:23:14Z

Adrian Covic, Paul Gusbeth-Tatomir, David Goldsmith (2008) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 23: 1 56-61<br/>

http://publicationslist.org/david.goldsmith/refid4 2008-05-11T21:23:14Z

OBJECTIVE: The overall objective of this study was to estimate the costs and outcomes associated with treatment with sevelamer for hyperphosphataemia compared with calcium-based binders. METHODS: Using published data on mortality and hospitalisation rates, a Markov model was developed to predict health outcomes and associated costs for the treatment of hyperphosphataemia using either sevelamer or ...<br/><br/>Matthew J Taylor, Heba A Elgazzar, Stephen Chaplin, David Goldsmith, Donald A Molony (2008) <i>Curr Med Res Opin</i> <i></i> <i></i> 24: 2 601-608<br/>

http://publicationslist.org/david.goldsmith/refid7 2008-05-11T21:23:14Z

Sevelamer (Renagel), an orally administered metal-free cationic hydrogel polymer/resin that binds dietary phosphate in the gastrointestinal (GI) tract, is approved for use in the US, Europe and several other countries for the treatment of hyperphosphataemia in adult patients with end-stage renal disease (ESRD) on haemodialysis or peritoneal dialysis.Clinical evidence shows that sevelamer was at le...<br/><br/>David R Goldsmith, Lesley J Scott, Risto S Cvetković, Greg L Plosker (2008) <i>Drugs</i> <i></i> <i></i> 68: 1 85-104<br/>

http://publicationslist.org/david.goldsmith/refid2 2008-05-11T21:23:14Z

We report a case of post-transplantation lymphoproliferative disorder presenting as a symptomatic lymphocele 12 years after cadaveric renal transplantation for IgA nephropathy. The presentation, imaging, and management are discussed. We review current literature concerning PTLD, post-transplantation lymphoceles, and state-of-the-art imaging techniques.<br/><br/> Khan, Ahmed, Challacombe, Goldsmith, Steward (2008) <i>Int Urol Nephrol</i> <i></i> <i></i> : <br/>

http://publicationslist.org/david.goldsmith/refid1 2008-05-11T21:23:14Z

Richard Hull, David Goldsmith (2008) <i>Practitioner</i> <i></i> <i></i> 252: 1703 30, 32-34, 37<br/>

http://publicationslist.org/david.goldsmith/refid3 2008-05-11T21:23:14Z

Calciphylaxis-calcific uremic arteriolopathy, is a serious disorder of arteriolar calcification of the arteriole media and is associated with endovascular fibrosis and thrombosis in subcutaneous adipose tissue. It frequently results in severe ischemia, intense pain, and tissue necrosis with nonhealing skin ulcerations. It usually occurs in chronic kidney disease and especially in patients requirin...<br/><br/> Hayden, Goldsmith, Sowers, Khanna (2008) <i>Int Urol Nephrol</i> <i></i> <i></i> : <br/>

http://publicationslist.org/david.goldsmith/refid19 2008-05-11T21:23:14Z

CASE REPORT: Septic arthritis due to Klebsiella species is a rare but serious infection that may destroy a joint and cause serious immobility. This is a report of two immunocompromised adult patients presenting with acute septic arthritis due to extended spectrum beta lactamase producing Klebsiella pneumoniae. The infection was treated successfully with a course of meropenem and amikacin in combin...<br/><br/>Silke Schelenz, Kate Bramham, David Goldsmith (2007) <i>Joint Bone Spine</i> <i></i> <i></i> 74: 3 275-278<br/>

http://publicationslist.org/david.goldsmith/refid18 2008-05-11T21:23:14Z

David Goldsmith (2007) <i>Practitioner</i> <i></i> <i></i> 251: 1691 35-6, 38, 41-2<br/>

http://publicationslist.org/david.goldsmith/refid17 2008-05-11T21:23:14Z

Nigel Kendall, David Goldsmith (2007) <i>Practitioner</i> <i></i> <i></i> 251: 1691 <br/>

http://publicationslist.org/david.goldsmith/refid20 2008-05-11T21:23:14Z

Adrian Covic, David J A Goldsmith (2007) <i>Semin Dial</i> <i></i> <i></i> 20: 2 170-171<br/>

http://publicationslist.org/david.goldsmith/refid21 2008-05-11T21:23:14Z

Adrian Covic, Paul Gusbeth-Tatomir, David J A Goldsmith (2007) <i>Semin Dial</i> <i></i> <i></i> 20: 2 158-169<br/>

http://publicationslist.org/david.goldsmith/refid22 2008-05-11T21:23:14Z

Ashraf Mikhail, David Goldsmith (2007) <i>N Engl J Med</i> <i></i> <i></i> 356: 9 956-7; author reply 958-9<br/>

http://publicationslist.org/david.goldsmith/refid23 2008-05-11T21:23:14Z

Both chronic kidney disease (CKD) and type II diabetes mellitus (DM) are increasing in frequency among Western populations and both are potent risk factors for the development of anaemia. The presence of CKD and diabetes together represent the most important aetiopathogenic combination for the development of anaemia. New evidence has highlighted some of the underlying mechanisms which make diabeti...<br/><br/>S Al-Khoury, B Afzali, N Shah, S Thomas, P Gusbeth-Tatomir, D Goldsmith, A Covic (2007) <i>Int J Clin Pract</i> <i></i> <i></i> 61: 2 281-289<br/>

http://publicationslist.org/david.goldsmith/refid16 2008-05-11T21:23:14Z

For a long time, the inhibition of the renin-angiotensin-aldosterone (RAA) axis has been considered a must in almost all patients with progressive chronic kidney disease (CKD), with the aim of reducing the rate of progression to end-stage renal disease (ESRD). However, recent data from a meta-analysis, including the ALLHAT study, and a study in Canadian diabetic patients questioned the usefulness ...<br/><br/>Adrian Covic, Paul Gusbeth-Tatomir, David J A Goldsmith (2007) <i>Int Urol Nephrol</i> <i></i> <i></i> 39: 2 571-576<br/>

http://publicationslist.org/david.goldsmith/refid14 2008-05-11T21:23:14Z

Francesco Locatelli, David Goldsmith (2007) <i>J Nephrol</i> <i></i> <i></i> 20: 3 265-267<br/>

http://publicationslist.org/david.goldsmith/refid9 2008-05-11T21:23:14Z

Biopharmaceuticals have revolutionized the treatment and management of many diseases. The advent of recombinant erythropoietins has greatly benefited patients with anemia related to chronic kidney disease and cancer, virtually eliminating the need for blood transfusions. Currently, the patents for many biopharmaceutical molecules have expired or are approaching expiration and a number of biosimila...<br/><br/>David Goldsmith, Martin Kuhlmann, Adrian Covic (2007) <i>Clin Exp Nephrol</i> <i></i> <i></i> 11: 3 191-195<br/>

http://publicationslist.org/david.goldsmith/refid15 2008-05-11T21:23:14Z

Liviu Segall, Adrian Covic, David J A Goldsmith (2007) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 22: 9 2435-2439<br/>

http://publicationslist.org/david.goldsmith/refid11 2008-05-11T21:23:14Z

Renal dysfunction is uncommon in patients with leukemic infiltration of the kidney due to Chronic Lymphocytic Leukanemia (CLL). Granulomatous interstitial nephritis (GIN) is also rare, but a characteristic hallmark of certain diseases such as sarcoidosis and tuberculosis. GIN has been associated with medications, infections, inflammation, Wegener's granulomatosis, and jejuno-ileal bypass. GIN comb...<br/><br/>Anil V Kamat, David Goldsmith, Patrick O'Donnell, Jon van der Walt, Robert Carr (2007) <i>Ren Fail</i> <i></i> <i></i> 29: 6 763-765<br/>

http://publicationslist.org/david.goldsmith/refid5 2008-05-11T21:23:14Z

We recently identified an erythrocyte nucleotide accumulating in end-stage renal disease as 4-pyridone-3-carboxamide ribonucleotide triphosphate (4PYTP), a nucleotide never described previously. Plasma tryptophan concentration has been previously reported to be reduced in patients in chronic renal failure that is in turn associated with elevated precursors of tryptophan metabolism, including L -ky...<br/><br/>A Laurence, S M Edbury, A M Marinaki, R T Smolenski, D J A Goldsmith, H A Simmonds, E A Carrey (2007) <i>Clin Exp Med</i> <i></i> <i></i> 7: 4 135-141<br/>

http://publicationslist.org/david.goldsmith/refid12 2008-05-11T21:23:14Z

Behdad Afzali, David J A Goldsmith (2007) <i>Lancet</i> <i></i> <i></i> 370: 9586 482; author reply 482-482; author reply 483<br/>

http://publicationslist.org/david.goldsmith/refid13 2008-05-11T21:23:14Z

Kerem Atalar, Behdad Afzali, Boris Lams, M Fahim Tungekar, David J A Goldsmith (2007) <i>Lancet</i> <i></i> <i></i> 370: 9582 <br/>

http://publicationslist.org/david.goldsmith/refid35 2008-05-11T21:23:14Z

In renal transplantation the calcineurin inhibitors (CNIs) have played a crucial role in the reduction in acute rejection rates. Unfortunately this has not been matched by an improvement in long-term graft survival rate. The development of chronic allograft nephropathy (CAN) is the second most common cause of graft loss, after death from cardiovascular causes. CAN has a multifactorial aetiology th...<br/><br/>R W C Kingston, D J A Goldsmith (2006) <i>Minerva Urol Nefrol</i> <i></i> <i></i> 58: 1 23-28<br/>

http://publicationslist.org/david.goldsmith/refid34 2008-05-11T21:23:14Z

Improvements in patient care and longevity on dialysis programmes together with the increased numbers of patients referred for renal replacement therapy will inevitably result in enlarging numbers of subjects with functioning renal transplants. While this translates to a boon for the patients in terms of survival and quality of life, a very real problem has begun to emerge, that of post-transplant...<br/><br/>David Goldsmith, Salam Al-Khoury, Nilesh Shah, Adrian Covic (2006) <i>Nephron Clin Pract</i> <i></i> <i></i> 104: 2 c69-c74<br/>

http://publicationslist.org/david.goldsmith/refid36 2008-05-11T21:23:14Z

AIMS/HYPOTHESIS: We investigated the relationship between haemoglobin (Hb) and diabetes in patients with renal disease. SUBJECTS, MATERIALS AND METHODS: All adult patients with stable chronic kidney disease attending renal or diabetic outpatient clinics in a six-month period were identified. Patients' notes and electronic patient records were used to build a comprehensive biochemical and clinical ...<br/><br/>S Al-Khoury, B Afzali, N Shah, A Covic, S Thomas, D J Goldsmith (2006) <i>Diabetologia</i> <i></i> <i></i> 49: 6 1183-1189<br/>

http://publicationslist.org/david.goldsmith/refid39 2008-05-11T21:23:14Z

Adrian Covic, Paul Gusbeth-Tatomir, David J A Goldsmith (2006) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 21: 4 854-858<br/>

http://publicationslist.org/david.goldsmith/refid33 2008-05-11T21:23:14Z

Two organ recipients developed serologic evidence of syphilis infection after renal transplantation from a common deceased donor with a history of treated syphilis. Testing of donor serum for syphilis, which occurred after transplantation, gave results interpreted as consistent with past infection. However, subsequent serologic results in the recipients suggested transmission of infection at trans...<br/><br/>N J Cortes, B Afzali, D MacLean, D J A Goldsmith, H O'Sullivan, J Bingham, D A Lewis, E MacMahon, C Y W Tong, G Koffman (2006) <i>Am J Transplant</i> <i></i> <i></i> 6: 10 2497-2499<br/>

http://publicationslist.org/david.goldsmith/refid44 2008-05-11T21:23:14Z

BACKGROUND: Measures of aortic stiffness--aortic pulse wave velocity (PWV) and augmentation index (AIx)--have been shown to be powerful predictors of survival in adult haemodialysis (HD) patients. Very few data have been reported regarding arterial stiffness in paediatric renal populations. METHODS: PWV and aortic AIx were determined from contour analysis of arterial waveforms recorded by applanat...<br/><br/>Adrian Covic, Nicoleta Mardare, Paul Gusbeth-Tatomir, Ovidiu Brumaru, Cristina Gavrilovici, Mihaela Munteanu, Octavian Prisada, David J A Goldsmith (2006) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 21: 3 729-735<br/>

http://publicationslist.org/david.goldsmith/refid37 2008-05-11T21:23:14Z

BACKGROUND: The commonest cause of renal transplant loss is death with a functioning graft, usually from an excess of cardiovascular disease (CVD). Anaemia is becoming increasingly recognized as a reversible risk factor for the development of CVD. The purpose of this study was to estimate the prevalence of post-transplantation anaemia (PTA) in a large population of stable adult and paediatric rena...<br/><br/>Salam Al-Khoury, Nilesh Shah, Behdad Afzali, Adrian Covic, Judy Taylor, David Goldsmith (2006) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 21: 7 1974-1980<br/>

http://publicationslist.org/david.goldsmith/refid32 2008-05-11T21:23:14Z

BACKGROUND: Chronic kidney disease (CKD) patients have a 3-30-fold increased risk of death compared with the general population. This mortality difference is even more pronounced in younger subjects. Two markers of aortic stiffness--aortic pulse wave velocity (PWV) and augmentation index (AIx)--have been prospectively related to all-cause and cardiovascular (CV) mortality in end-stage renal diseas...<br/><br/>Adrian Covic, Nicoleta Mardare, Paul Gusbeth-Tatomir, Octavian Prisada, Radu Sascau, David J A Goldsmith (2006) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 21: 10 2859-2866<br/>

http://publicationslist.org/david.goldsmith/refid26 2008-05-11T21:23:14Z

BACKGROUND: Clopidogrel, in addition to aspirin, has become a common treatment of acute coronary syndrome and for stent thrombosis prevention, when given before percutaneous transluminal coronary angioplasty. However, some patients turn out to have surgical coronary artery disease and are sent for coronary artery bypass grafting (CABG) where the irreversible effect of aspirin and clopidogrel on pl...<br/><br/>Ali A Haydar, Antoine B Abchee, Ihab I El-Hajj, Nabil M A Hujairi, Amer S Tfaili, Tarek Hatoum, Ayman Quateen, Rashed Bakri, Behdad Afzali, David J A Goldsmith (2006) <i>J Med Liban</i> <i></i> <i></i> 54: 1 11-16<br/>

http://publicationslist.org/david.goldsmith/refid25 2008-05-11T21:23:14Z

Renal disease is rare today in classic adult gout, and gout is rare in renal disease--especially in the young. Here we summarise studies in 158 patients from 31 kindreds diagnosed with familial juvenile hyperuricaemic nephropathy FJHN from a total of 230 kindred members studied in Great Britain. Some patients have been followed for up to 30 years, and allopurinol has ameliorated the progression of...<br/><br/>H A Simmonds, J S Cameron, D J Goldsmith, L D Fairbanks, G Venkat Raman (2006) <i>Nucleosides Nucleotides Nucleic Acids</i> <i></i> <i></i> 25: 9-11 1071-1075<br/>

http://publicationslist.org/david.goldsmith/refid28 2008-05-11T21:23:14Z

Anemia in the setting of chronic kidney disease is a well-recognized phenomenon that is associated with decreasing renal function and deficiency of or resistance to erythropoietin. However, anemia in the post-renal transplantation setting has received comparatively less attention in the literature. In this review, we aim critically to appraise the available literature regarding posttransplantation...<br/><br/>Behdad Afzali, Salam Al-Khoury, Nilesh Shah, Ashraf Mikhail, Adrian Covic, David Goldsmith (2006) <i>Am J Kidney Dis</i> <i></i> <i></i> 48: 4 519-536<br/>

http://publicationslist.org/david.goldsmith/refid24 2008-05-11T21:23:14Z

BACKGROUND: Few studies have addressed the description of serial changes in left ventricular mass (LVM) and relevant risk factors. All these studies were initiated before the implementation of EBPG or K/DOQI guidelines. The aims of our study were to prospectively describe trends in left ventricular (LV) structure and function, evaluate risk factors for progression of LVM derived from serial echoca...<br/><br/>Adrian Covic, Nicoleta G I Mardare, Serban Ardeleanu, Octavian Prisada, Paul Gusbeth-Tatomir, David J A Goldsmith (2006) <i>J Nephrol</i> <i></i> <i></i> 19: 6 783-793<br/>

http://publicationslist.org/david.goldsmith/refid29 2008-05-11T21:23:14Z

The availability of biopharmaceuticals has been increasing over the past decade and as their patents expire, the emergence of biosimilar agents approaches. The primary issue of concern for the safety of these agents is the potential for immunogenicity. Both product- and host-related factors have documented impact on the immune response, but many factors are still unknown. Although in many cases th...<br/><br/>Michele Kessler, David Goldsmith, Huub Schellekens (2006) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 21 Suppl 5: v9-12<br/>

http://publicationslist.org/david.goldsmith/refid31 2008-05-11T21:23:14Z

There is increasing evidence that even mild renal dysfunction is a novel potent cardiovascular risk factor in the general elderly population. With more severe renal impairment, cardiovascular risk increases proportionately. This issue deserves attention, as chronic kidney disease (CKD) is predominantly a disease of the elderly, and the mean age of end-stage renal disease patients entering dialysis...<br/><br/>Adrian Covic, Paul Gusbeth-Tatomir, David J A Goldsmith (2006) <i>Int Urol Nephrol</i> <i></i> <i></i> 38: 2 371-379<br/>

http://publicationslist.org/david.goldsmith/refid30 2008-05-11T21:23:14Z

David Goldsmith (2006) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 21 Suppl 5: v1-v3<br/>

http://publicationslist.org/david.goldsmith/refid47 2008-05-11T21:23:14Z

According to recent data, arterial stiffness is a major independent risk factor for cardiovascular morbidity and mortality in both the general and renal populations. Because of several factors (vascular calcifications among them), large arteries are stiffer in patients with chronic kidney disease compared with the nonrenal population, contributing to the enormous cardiovascular mortality in renal ...<br/><br/>Adrian Covic, Paul Gusbeth-Tatomir, David J A Goldsmith (2005) <i>Am J Kidney Dis</i> <i></i> <i></i> 45: 6 965-977<br/>

http://publicationslist.org/david.goldsmith/refid49 2008-05-11T21:23:14Z

Development of microalbuminuria increases the risk for cardiovascular disease (CVD) in type 2 diabetes. The nature of this relationship is unclear but may involve arterial stiffness, an independent risk marker for CVD mortality. Aortic pulse wave velocity (Ao-PWV) and albumin creatinine ratio (ACR) were measured in 134 consecutive patients with type 2 diabetes without overt renal impairment (serum...<br/><br/>Andrew Smith, Janaka Karalliedde, Lorenita De Angelis, David Goldsmith, Giancarlo Viberti (2005) <i>J Am Soc Nephrol</i> <i></i> <i></i> 16: 4 1069-1075<br/>

http://publicationslist.org/david.goldsmith/refid50 2008-05-11T21:23:14Z

BACKGROUND: Chronic allograft nephropathy (CAN) is the most common cause of long-term renal-allograft dysfunction and the second most common cause of transplant loss. There are concerns that prolonged patient exposure to calcineurin inhibitors (CNIs) exacerbates or promotes the process of CAN. METHODS: In our unit, we carried out an observational study over the period 2000 to 2003 using low-dose m...<br/><br/>Behdad Afzali, Sapna Shah, Paramit Chowdhury, Helen O'sullivan, John Taylor, David Goldsmith (2005) <i>Transplantation</i> <i></i> <i></i> 79: 3 304-309<br/>

http://publicationslist.org/david.goldsmith/refid45 2008-05-11T21:23:14Z

Increased aortic stiffness-measured as aortic augmentation index (AIx), a global stiffness marker-has emerged as a powerful predictor of survival in hemodialysis (HD). A single HD session is known to produce considerable improvement in aortic stiffness. We set out, for the first time, to examine the relative contributions to the post-HD drastic improvement in aortic stiffness of ultrafiltration ra...<br/><br/>Nicoleta-Genoveva Mardare, David J A Goldsmith, Paul Gusbeth-Tatomir, Adrian Covic (2005) <i>Hemodial Int</i> <i></i> <i></i> 9: 4 376-382<br/>

http://publicationslist.org/david.goldsmith/refid51 2008-05-11T21:23:14Z

BACKGROUND: CyA A (CyA) may induce intrarenal vasoconstriction, endothelial dysfunction, and hypertension. There are only two contradictory reports describing the acute effect of CyA on renal resistances measured by color Doppler flowmetry. Therefore, we studied the acute influence of oral CyA on arterial haemodynamics by assessing simultaneous changes in blood pressure, applanation tonometry-deri...<br/><br/>Adrian Covic, Nicoleta Mardare, Paul Gusbeth-Tatomir, Irina Buhaescu, David J A Goldsmith (2005) <i>Kidney Int</i> <i></i> <i></i> 67: 2 732-737<br/>

http://publicationslist.org/david.goldsmith/refid46 2008-05-11T21:23:14Z

OBJECTIVE: To report the largest single series of renal transplant patients (adults and children) with urolithiasis, assess the risk factors associated with urolithiasis in renal transplant recipients, and report the outcome of the multimodal management by endourological and open procedures. PATIENTS AND METHODS: The records of all patients undergoing renal transplantation between 1977 and 2003 we...<br/><br/>Ben Challacombe, Prokar Dasgupta, Richard Tiptaft, Jonathan Glass, Geoff Koffman, David Goldsmith, Mohammed S Khan (2005) <i>BJU Int</i> <i></i> <i></i> 96: 3 385-389<br/>

http://publicationslist.org/david.goldsmith/refid41 2008-05-11T21:23:14Z

BACKGROUND: Abnormalities of diurnal blood pressure (BP) rhythm ("nondipping") are well-described in dialysis patients, and have prognostic importance. It is controversial whether successful renal transplantation (RTx) improves diurnal BP rhythm. To date, no study has attempted to define and model the evolution of diurnal BP rhythm profiles from dialysis to engraftment, focusing on the immediate (...<br/><br/>Adrian Covic, Paul Gusbeth-Tatomir, Nicoleta Mardare, Irina Buhaescu, David J A Goldsmith (2005) <i>Transplantation</i> <i></i> <i></i> 80: 9 1168-1173<br/>

http://publicationslist.org/david.goldsmith/refid42 2008-05-11T21:23:14Z

Emanuela Orlandi, Asif Butt, David Goldsmith, R Swaminathan (2005) <i>Clin Chem</i> <i></i> <i></i> 51: 10 1982-1983<br/>

http://publicationslist.org/david.goldsmith/refid40 2008-05-11T21:23:14Z

Given the potency of modern immunosuppressive agents, kidney transplantation across alloantingen barriers is a routine phenomenon with excellent 1-year graft survival in most centers. However, the improvement in 1-year graft survival has not been matched by improvements in long-term graft function and chronic allograft nephropathy (CAN) remains the second commonest cause of graft attrition over ti...<br/><br/>Behdad Afzali, Anna L Taylor, David J A Goldsmith (2005) <i>Kidney Int</i> <i></i> <i></i> 68: 6 2429-2443<br/>

http://publicationslist.org/david.goldsmith/refid43 2008-05-11T21:23:14Z

BACKGROUND: Increased aortic stiffness markers - aortic pulse wave velocity (PWV) and augmentation index (AIx) - are powerful predictors of survival in ESRD patients - well-recognized for the high prevalence of coronary artery disease (CAD) and unusually high PWV and AIx. Recently, decreased aortic compliance has been shown to be predictive of primary coronary events in hypertensive patients with ...<br/><br/>A Covic, A A Haydar, P Bhamra-Ariza, P Gusbeth-Tatomir, D J Goldsmith (2005) <i>J Nephrol</i> <i></i> <i></i> 18: 4 388-396<br/>

http://publicationslist.org/david.goldsmith/refid70 2008-05-11T21:23:14Z

BACKGROUND: Cardiovascular disease (CVD) is more common in patients with renal failure, even after renal transplantation. We wished to examine the relationship between markers of inflammation and CVD in stable renal transplant patients. METHODS: Ninety stable renal transplant outpatients with no recent illnesses or rejection were invited for study. Blood was drawn for a variety of inflammatory mar...<br/><br/>Rashed S Bakri, Behdad Afzali, Adrian Covic, Rajaventhan Sriskantharan, Paul Bharma-Ariza, Won-Ho Park, Mohanaluxmi Sriharan, Neil Dalton, Anthony S Wierzbicki, Martin A Crook, David J A Goldsmith (2004) <i>Clin Transplant</i> <i></i> <i></i> 18: 2 201-204<br/>

http://publicationslist.org/david.goldsmith/refid71 2008-05-11T21:23:14Z

BACKGROUND: Accurate diagnosis of hypertension is essential in chronic kidney disease patients, as it is linked to increased left ventricular mass, stroke, cardiovascular mortality and morbidity, and progression to end-stage renal disease. Elevated blood pressure (BP) detected by ambulatory BP monitoring (ABPM) has been shown to be predictive of worse outcome in chronic kidney disease patients. An...<br/><br/>Ali A Haydar, Adrian Covic, Satish Jayawardene, Mohsen Agharazii, Eilish Smith, Isabel Gordon, Helen O'Sullivan, David J A Goldsmith (2004) <i>Transplantation</i> <i></i> <i></i> 77: 6 849-853<br/>

http://publicationslist.org/david.goldsmith/refid72 2008-05-11T21:23:14Z

A patient with isolated severe epistaxis and non-specific history or examination findings was shown to have anaemia, raised erythrocyte sedimentation rate (ESR), renal impairment and raised total protein with hypercoagulable blood. Waldenstrom's macroglobulinaemia was diagnosed after serum electrophoresis and bone marrow studies. Urgent plasma exchange and chemotherapy were undertaken to good effe...<br/><br/>Karim Bakri, Ali A Haydar, Jeremy Davis, Jon Wan Der Walt, Majid Kazmi, David J A Goldsmith (2004) <i>Int J Clin Pract</i> <i></i> <i></i> 58: 1 81-82<br/>

http://publicationslist.org/david.goldsmith/refid69 2008-05-11T21:23:14Z

BACKGROUND: Patients with end-stage renal disease (ESRD) are at increased risk of cardiovascular mortality and morbidity. Many complications arise in ESRD patients as a result of the twin arterial pathologies of atherosclerosis and arteriosclerosis. Part of this latter process is calcification of the arterial media, which is thought significantly to increase vascular stiffness. The aim of our stud...<br/><br/>Ali A Haydar, Adrian Covic, Helen Colhoun, Michael Rubens, David J A Goldsmith (2004) <i>Kidney Int</i> <i></i> <i></i> 65: 5 1790-1794<br/>

http://publicationslist.org/david.goldsmith/refid68 2008-05-11T21:23:14Z

Ali A Haydar, Nabil Hujairi, Paramit Chowdhury, James Pattison, Allan Deacon, Robert Sarkany, David J A Goldsmith (2004) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 19: 5 1321-1322<br/>

http://publicationslist.org/david.goldsmith/refid73 2008-05-11T21:23:14Z

Behdad Afzali, Ali A Haydar, Katie Vinen, David J A Goldsmith (2004) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 19: 5 1032-1036<br/>

http://publicationslist.org/david.goldsmith/refid66 2008-05-11T21:23:14Z

Cardiovascular disease (CVD) is one of the major causes of mortality in patients with renal diseases, with increased odds ratio of mortality with risk factors as diverse as cholesterol, vascular stiffness, chronic inflammation and hyperhomocysteinemia. Several factors have been incriminated to explain the increase in coronary vascular calcification (CVC) in this particular population. Increased du...<br/><br/>Ophelia Dadzie, Nabil Ma Hujairi, Cliff Bucknall, Simon Redwood, Michael Rubens, David Goldsmith (2004) <i>J Nephrol</i> <i></i> <i></i> 17: 1 118-124<br/>

http://publicationslist.org/david.goldsmith/refid67 2008-05-11T21:23:14Z

Ali A Haydar, Nabil Hujairi, Bruce Kirkham, Robert Hangartner, David J A Goldsmith (2004) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 19: 5 1334-1335<br/>

http://publicationslist.org/david.goldsmith/refid83 2008-05-11T21:23:14Z

Ali A Haydar, David J A Goldsmith (2004) <i>J R Soc Med</i> <i></i> <i></i> 97: 1 27-28<br/>

http://publicationslist.org/david.goldsmith/refid65 2008-05-11T21:23:14Z

Rifampicin re-administration may cause immunologically mediated acute tubulo-interstitial injury. Retrospectively, 170 consecutive cases with acute renal failure (ARF) following re-treatment with rifampicin (71% males, 29% females, age 21 to 68 years) were analysed, which accounted for 12% of all ARF patients treated by two large dialysis referral centres in Romania, Timisoara and Iasi, between 19...<br/><br/>A Covic, O Golea, L Segall, Srinath Meadipudi, Liliana Munteanu, M Nicolicioiu, V Tudorache, Maria Covic, D J A Goldsmith (2004) <i>J Indian Med Assoc</i> <i></i> <i></i> 102: 1 20, 22-20, 25<br/>

http://publicationslist.org/david.goldsmith/refid86 2008-05-11T21:23:14Z

Interstitial pneumonitis is a rare disease that is seen in the context of some infections (e.g. PCP and CMV pneumonia), as side-effects of drugs (e.g. beta-blockers, amiodarone) and rarely in the context of renal transplantation. It manifests itself usually as a pneumonic illness; with symptoms of dyspnea, cough, fatigue and sometimes fever. Characteristic radiological changes are bilateral lower ...<br/><br/>Ali A Haydar, Mark Denton, Alex West, John Rees, David J A Goldsmith (2004) <i>Am J Transplant</i> <i></i> <i></i> 4: 1 137-139<br/>

http://publicationslist.org/david.goldsmith/refid80 2008-05-11T21:23:14Z

MMF (mycophenolate mofetil) has been proven to provide an effective immunosuppression by non-competitive selective reversible inhibition of IMPDH (inosine monophosphate dehydrogenase), the enzyme playing a crucial role in GTP biosynthesis. However, the exact metabolic changes induced by inhibition of IMPDH in target cells of the immune system have been the subject of recent debate. The aim of the ...<br/><br/>Piotr Jagodzinski, Slawomir Lizakowski, Ryszard T Smolenski, Ewa M Slominska, David Goldsmith, H Anne Simmonds, Boleslaw Rutkowski (2004) <i>Clin Sci (Lond)</i> <i></i> <i></i> 107: 1 69-74<br/>

http://publicationslist.org/david.goldsmith/refid79 2008-05-11T21:23:14Z

The immunosuppressant MMF (mycophenolate mofetil) has increasingly replaced AZA (azathioprine) in renal transplantation. MMF is a prodrug of MPA (mycophenolic acid), which inhibits lymphocyte IMPDH (inosine monophosphate dehydrogenase), thereby drastically decreasing GTP concentrations essential to lymphocyte proliferation in vitro and in vivo. Erythrocyte GTP concentrations are commonly elevated ...<br/><br/>David Goldsmith, Elizabeth A Carrey, Stephen Edbury, Ryszard T Smolenski, Piotr Jagodzinski, H Anne Simmonds (2004) <i>Clin Sci (Lond)</i> <i></i> <i></i> 107: 1 63-68<br/>

http://publicationslist.org/david.goldsmith/refid75 2008-05-11T21:23:14Z

BACKGROUND: Increased aortic stiffness markers--aortic pulse wave velocity (PWV) and augmentation index (AIx)--have emerged as powerful predictors of survival in haemodialysis (HD). Various and often contradictory abnormalities of endothelium-dependent (ED) and endothelium-independent (EID) vasomotor function, have been described in dialysis subjects, pre- and post-dialysis, using methods that are...<br/><br/>Adrian Covic, David J A Goldsmith, Paul Gusbeth-Tatomir, Maria Covic (2004) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 19: 3 637-643<br/>

http://publicationslist.org/david.goldsmith/refid78 2008-05-11T21:23:14Z

BACKGROUND: Coronary artery calcification measured by electron-beam computerized tomography (EBCT) correlates with plaque burden and vessel stenosis and is predictive of future cardiac events in the general population. Uremic vascular calcification is common and widespread, tends to be medial as well as intimal, and may not relate solely to atherosclerotic lesions. Despite this difference and in t...<br/><br/>Edward J Sharples, Divaka Pereira, Shaun Summers, John Cunningham, Michael Rubens, David Goldsmith, Muhammad M Yaqoob (2004) <i>Am J Kidney Dis</i> <i></i> <i></i> 43: 2 313-319<br/>

http://publicationslist.org/david.goldsmith/refid74 2008-05-11T21:23:14Z

Elevated blood pressure and diurnal blood pressure variation detected by ambulatory blood pressure monitoring has been shown to be predictive of worse outcome in end-stage renal disease patients in small studies. What has been lacking is a large study to determine whether these ambulatory blood pressure monitoring (ABPM)-derived variables are predictors of worse outcome in renal transplant recipie...<br/><br/>Ali A Haydar, Adrian Covic, Mohsen Agharazii, Satish Jayawardene, John Taylor, David J A Goldsmith (2004) <i>Am J Transplant</i> <i></i> <i></i> 4: 2 244-247<br/>

http://publicationslist.org/david.goldsmith/refid48 2008-05-11T21:23:14Z

Extensive evidence supports a pathogenic role for both local and systemic inflammation in acute coronary syndrome (ACS). The determination of inflammatory markers levels in combination with the new imaging modalities can be used to identify patients at high risk of future cardiovascular events. Interestingly, this inflammatory component is a novel therapeutic target in ACS.<br/><br/>Ihab I Elhajj, Ali A Haydar, Nabil M Hujairi, David J Goldsmith (2004) <i>J Med Liban</i> <i></i> <i></i> 52: 2 96-102<br/>

http://publicationslist.org/david.goldsmith/refid38 2008-05-11T21:23:14Z

Ali A Haydar, David J A Goldsmith (2004) <i>J Med Liban</i> <i></i> <i></i> 52: 3 156-159<br/>

http://publicationslist.org/david.goldsmith/refid55 2008-05-11T21:23:14Z

We have investigated an unusual nucleotide that accumulates, with precursors, in the erythrocytes of patients in uraemia. This nucleotide is related chemically to the NAD breakdown product, N1-methyl-2-pyridone-5-carboxamide (Me2Py), found in high concentrations in the plasma of uraemic patients. Both Me2Py and the nucleotide accumulate to high concentrations in the blood during uraemia: our inves...<br/><br/>E A Carrey, R T Smolenski, S M Edbury, A Laurence, A M Marinaki, J A Duley, L M Zhu, D J A Goldsmith, H A Simmonds (2004) <i>Nucleosides Nucleotides Nucleic Acids</i> <i></i> <i></i> 23: 8-9 1135-1139<br/>

http://publicationslist.org/david.goldsmith/refid54 2008-05-11T21:23:14Z

We show that GTP concentrations rise in the erythrocytes of renal transplant recipients receiving the immunosuppressant MMF, and demonstrate that this effect is not caused by poor renal function after engraftment. We propose a model that is consistent with our observations.<br/><br/>D J A Goldsmith, E A Carrey, S M Edbury, A M Marinaki, H A Simmonds (2004) <i>Nucleosides Nucleotides Nucleic Acids</i> <i></i> <i></i> 23: 8-9 1407-1409<br/>

http://publicationslist.org/david.goldsmith/refid53 2008-05-11T21:23:14Z

The case of a man with progressive breathlessness and pulmonary infiltration caused by AL amyloidosis associated with multiple myeloma is presented. There was a marked peripheral eosinophilia, which has not previously been described with amyloidosis.<br/><br/>A A Haydar, A Li, R Hilton, B Lams, R Hangartner, M Weber, D J A Goldsmith (2004) <i>Postgrad Med J</i> <i></i> <i></i> 80: 950 738-739<br/>

http://publicationslist.org/david.goldsmith/refid64 2008-05-11T21:23:14Z

BACKGROUND: Coronary artery calcification (CAC) measured by electron beam computed tomography (EBCT) correlates with plaque burden, vessel stenosis and is predictive of future cardiac events in the general population. Extensive CAC has been described recently in dialysis cohorts. For the first time we studied the relationship between CAC and coronary angiographic findings in patients with chronic ...<br/><br/>Ali A Haydar, Nabil M A Hujairi, Adrian A Covic, Divaka Pereira, Michael Rubens, David J A Goldsmith (2004) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 19: 9 2307-2312<br/>

http://publicationslist.org/david.goldsmith/refid52 2008-05-11T21:23:14Z

Ambulatory blood pressure monitoring (ABPM) has been developed to overcome recognized deficiencies and inaccuracies of classic (office) BP measurements in the diagnosis and management of hypertension (HTN). Although in adults it has become a valuable tool for the diagnosis and ongoing management of HTN, and its use has been documented in over 50 studies in children, few pediatric nephrologists sys...<br/><br/>Cristina Gavrilovici, David J A Goldsmith, Chris Reid, Paul Gubeth-Tatomir, Adrian Covic (2004) <i>J Nephrol</i> <i></i> <i></i> 17: 5 642-652<br/>

http://publicationslist.org/david.goldsmith/refid57 2008-05-11T21:23:14Z

There has been an explosion of interest in vascular calcification in the last 5 years. Four key "germinal" findings have fallen onto very fertile soil. First, on the background of an increasing cardiovascular disease burden it has been found that at least cross-sectionally, and in a limited fashion prospectively, achieved dialysis plasma phosphate levels are linked to all-cause and cardiovascular ...<br/><br/>David Goldsmith, Eberhard Ritz, Adrian Covic (2004) <i>Kidney Int</i> <i></i> <i></i> 66: 4 1315-1333<br/>

http://publicationslist.org/david.goldsmith/refid56 2008-05-11T21:23:14Z

Cytomegalovirus (CMV) is usually a complication of renal/solid organ or bone marrow transplantation. We describe three cases of severe CMV in the context of vasculitis immunosuppression.<br/><br/>A M Elsharkawy, F Perrin, C K T Farmer, I C Abbs, P Muir, L J Brown, E M E MacMahon, D J A Goldsmith (2004) <i>Clin Nephrol</i> <i></i> <i></i> 62: 4 319-326<br/>

http://publicationslist.org/david.goldsmith/refid62 2008-05-11T21:23:14Z

B Afzali, D J A Goldsmith (2004) <i>J Clin Pathol</i> <i></i> <i></i> 57: 7 673-674<br/>

http://publicationslist.org/david.goldsmith/refid63 2008-05-11T21:23:14Z

Ambulatory blood pressure (ABP) monitoring has been in use for nearly four decades. In that time, the advantages of using a more reproducible and accurate method to assess the true contribution of blood pressure to the cardiovascular risk profile of patients have steadily become more clearly established, balanced by the additional expense and expertise involved. In nephrology, and in particular in...<br/><br/>Adrian Covic, Ali A Haydar, David Goldsmith (2004) <i>Semin Dial</i> <i></i> <i></i> 17: 4 255-259<br/>

http://publicationslist.org/david.goldsmith/refid61 2008-05-11T21:23:14Z

Behdad Afzali, Ali A Haydar, Katie Vinen, David J A Goldsmith (2004) <i>J Am Soc Nephrol</i> <i></i> <i></i> 15: 8 2161-2168<br/>

http://publicationslist.org/david.goldsmith/refid60 2008-05-11T21:23:14Z

Urinary tract obstruction is a common problem associated with many complications. Decompression of an enlarged bladder has been associated with several complications, mainly vesicular bleeding. We report a case of a 42-year-old male patient who developed bilateral renal subcapsular hematomas secondary to relief of an extremely enlarged bladder.<br/><br/>Ali A Haydar, Nabil M Hujairi, Aiman Quateen, Tarek Hatoum, David J A Goldsmith (2004) <i>Int J Urol</i> <i></i> <i></i> 11: 8 663-665<br/>

http://publicationslist.org/david.goldsmith/refid58 2008-05-11T21:23:14Z

Anemia is a common feature of chronic renal dysfunction and is associated with significant morbidity and mortality. Although acquired insufficiency of erythropoietin is virtually universal, iron deficiency is also a common contributor to the development of anemia. Iron replacement, in particular via the intravenous route, has become commonplace and results in improved hematocrits either on its own...<br/><br/>Behdad Afzali, David J A Goldsmith (2004) <i>J Nephrol</i> <i></i> <i></i> 17: 4 487-495<br/>

http://publicationslist.org/david.goldsmith/refid59 2008-05-11T21:23:14Z

BACKGROUND: Measurements of aortic stiffness [aortic pulse wave velocity (PWV) and augmentation index (Alx)] have been established as powerful predictors of survival on hemodialysis (HD). Abnormal endothelial-dependent and endothelial-independent vascular reactivity and increased arterial stiffness are commonly described in HD patients. There is, however, a lack of information on the comparative i...<br/><br/>Adrian Covic, David J A Goldsmith, Laura Florea, Paul Gusbeth-Tatomir, Maria Covic (2004) <i>Perit Dial Int</i> <i></i> <i></i> 24: 4 365-372<br/>

http://publicationslist.org/david.goldsmith/refid91 2008-05-11T21:23:14Z

A man born in 1944 presented with an episode of macroscopic haematuria during a urinary tract infection in 1988. He was unusually tall at 2 metres. An intravenous pyelogram and an abdominal ultrasound disclosed the presence of bilaterally enlarged polycystic kidneys and a polycystic liver. There was a family history of renal disease. Plasma creatinine (180 micro mol/l) and blood pressure (150/100 ...<br/><br/>W Al-Hakim, D J A Goldsmith (2003) <i>Postgrad Med J</i> <i></i> <i></i> 79: 934 474-475<br/>

http://publicationslist.org/david.goldsmith/refid90 2008-05-11T21:23:14Z

A Slack, D J A Goldsmith (2003) <i>Postgrad Med J</i> <i></i> <i></i> 79: 934 477, 480-477, 481<br/>

http://publicationslist.org/david.goldsmith/refid92 2008-05-11T21:23:14Z

BACKGROUND: Acute liver failure (ALF) as a result of mushroom poisoning is associated with a high mortality (particularly in children), despite optimal medical therapy (OMT), including charcoal haemoperfusion and haemodiafiltration. MARS is a new, cell-free, extracorporeal liver assistance method utilizing an albumin dialysate for the removal of albumin-bound toxins. METHODS: We describe the first...<br/><br/>Adrian Covic, David J A Goldsmith, Paul Gusbeth-Tatomir, Carmen Volovat, Alexandru G Dimitriu, Florin Cristogel, Aurel Bizo (2003) <i>Liver Int</i> <i></i> <i></i> 23 Suppl 3: 21-27<br/>

http://publicationslist.org/david.goldsmith/refid96 2008-05-11T21:23:14Z

BACKGROUND: Since the 1960s chronic hemodialysis (HD) has been recognized as a risk factor for the development of infective endocarditis (IE). Historically, it has been particularly associated with vascular access via dual lumen catheters. We wished to examine the risk factors for, and consequences of, IE in the modern dialysis era. METHODS: Cases of IE (using the Duke criteria) at St. Thomas' Hos...<br/><br/>Timothy Doulton, Nikhant Sabharwal, Hugh S Cairns, Silke Schelenz, Susannah Eykyn, Patrick O'Donnell, John Chambers, Conell Austen, David J A Goldsmith (2003) <i>Kidney Int</i> <i></i> <i></i> 64: 2 720-727<br/>

http://publicationslist.org/david.goldsmith/refid89 2008-05-11T21:23:14Z

Statins are now widely prescribed and without doubt save many lives. However there are rare potentially serious side-effects, including acute renal failure. Patient education and physician vigilence are vital.<br/><br/>Rashed Bakri, Joe Wang, Anthony S Wierzbicki, David Goldsmith (2003) <i>Int J Cardiol</i> <i></i> <i></i> 91: 1 107-109<br/>

http://publicationslist.org/david.goldsmith/refid95 2008-05-11T21:23:14Z

INTRODUCTION: The aim of the present study is to understand the nature of acid-base disorders in critically ill patients with acute renal failure (ARF) using the biophysical principles described by Stewart and Figge. A retrospective controlled study was carried out in the intensive care unit of a tertiary hospital. MATERIALS AND METHODS: Forty patients with ARF, 40 patients matched for Acute Physi...<br/><br/>Jens Rocktaeschel, Hiroshi Morimatsu, Shigehiko Uchino, Donna Goldsmith, Stephanie Poustie, David Story, Geoffrey Gutteridge, Rinaldo Bellomo (2003) <i>Crit Care</i> <i></i> <i></i> 7: 4 <br/>

http://publicationslist.org/david.goldsmith/refid94 2008-05-11T21:23:14Z

Rashed S Bakri, Matthew Prime, Ali Haydar, Jonathan Glass, David J A Goldsmith (2003) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 18: 9 1917-1919<br/>

http://publicationslist.org/david.goldsmith/refid93 2008-05-11T21:23:14Z

Rachel Jones, Sapna Shah, Eithne E M MacMahon, David J A Goldsmith (2003) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 18: 9 1920-1922<br/>

http://publicationslist.org/david.goldsmith/refid81 2008-05-11T21:23:14Z

In renal transplant recipients, hypertension is common and associated with increased cardiovascular and allograft rejection risks. Ambulatory blood pressure monitoring is required for its accurate diagnosis and adequate treatment, as it clearly offers several advantages over office or casual blood pressure measurements. First, it correlates better with target-organ damage and with cardiovascular m...<br/><br/>Adrian Covic, Liviu Segall, David J A Goldsmith (2003) <i>Transplantation</i> <i></i> <i></i> 76: 11 1640-1642<br/>

http://publicationslist.org/david.goldsmith/refid82 2008-05-11T21:23:14Z

BACKGROUND: Patients with end-stage renal disease on dialysis have among the highest cardiovascular event rates documented. Abnormal nitric oxide (NO)-dependent endothelial reactivity and increased arterial stiffness are commonly described in hemodialysis (HD) patients. Measures of aortic stiffness--aortic pulse wave velocity (PWV) and augmentation index (AGI)--have been shown to be powerful predi...<br/><br/>A Covic, D J A Goldsmith, P Gusbeth-Tatomir, I Buhaescu, M Covic (2003) <i>Transplantation</i> <i></i> <i></i> 76: 11 1573-1577<br/>

http://publicationslist.org/david.goldsmith/refid77 2008-05-11T21:23:14Z

OBJECTIVE: To evaluate BP control, white coat hypertension (WCH) and abnormal circadian variability in a significant outpatient sample of renal transplant (RTx) subjects, normotensive at the last regular visit. METHODS: ABPM (Spacelab 90217) was performed every 15 min between 07:00-23:00 h and every 30 min between 23:01-06.59 h. in all patients (N = 68, 39M, S-Cr. = 153 +/- 49 mumol/l) normotensiv...<br/><br/>A Covic, D J Goldsmith, P Gusbeth-Tatomir, Anca Seica, S Jayawardene, M Agharazii, B Afzali (2003) <i>Rev Med Chir Soc Med Nat Iasi</i> <i></i> <i></i> 107: 1 89-97<br/>

http://publicationslist.org/david.goldsmith/refid76 2008-05-11T21:23:14Z

Hyperparathyroidism is an important sequela of chronic renal failure, remains a considerable challenge to nephrologists, and can be seen as inevitable in patients undergoing long-term renal replacement therapy. As time with renal disease increases then so does the cumulative risk of hyperparathyroidism, and the eventual need for surgical parathyroidectomy when hyperparathyroidism becomes refractor...<br/><br/>S A Jayawardene, A Covic, N Malikian, W J Owen, P O'Donnell, J Taylor, G C Koffman, D J Goldsmith (2003) <i>Rev Med Chir Soc Med Nat Iasi</i> <i></i> <i></i> 107: 3 636-640<br/>

http://publicationslist.org/david.goldsmith/refid97 2008-05-11T21:23:14Z

Karim Bakri, David J A Goldsmith (2003) <i>Nephron Clin Pract</i> <i></i> <i></i> 94: 2 c27-c28<br/>

http://publicationslist.org/david.goldsmith/refid84 2008-05-11T21:23:14Z

Cardiovascular disease (CVD) rates in dialysis patients are very high. One of the many associated risk factors is chronic inflammation. The relationship of baseline markers of chronic inflammation with the presence of CVD was assessed in a large cohort of stable dialysis patients. Median time (IQR) on dialysis treatment was 20(9-52) months. Forty-one patients had CVD (as defined by the history / c...<br/><br/>Behdad Afzali, Rached S Bakri, Paul Bharma-Ariza, Peter J Lumb, Neil Dalton, Neil C Turner, Anthony S Wierzbicki, Martin A Crook, David J Goldsmith (2003) <i>J Nephrol</i> <i></i> <i></i> 16: 4 540-545<br/>

http://publicationslist.org/david.goldsmith/refid87 2008-05-11T21:23:14Z

PURPOSE OF REVIEW: To identify and evaluate recent (2000-2003) published studies employing ambulatory blood pressure monitoring in patients with chronic renal failure, on dialysis, and after renal transplantation. RECENT FINDINGS: We discuss several studies that have employed ambulatory blood pressure monitoring to refine the analysis of the link between blood pressure levels, and diurnal alterati...<br/><br/>Adrian Covic, Ali A Haydar, David J A Goldsmith (2003) <i>Curr Opin Nephrol Hypertens</i> <i></i> <i></i> 12: 6 645-648<br/>

http://publicationslist.org/david.goldsmith/refid85 2008-05-11T21:23:14Z

Due to the impressive cardiovascular (CV) morbidity and mortality in uremic patients, assessment of CV risk factors in the dialysis population is a crucial challenge in nephrology. Cardiovascular risk factors in dialysis patients may have a different significance in ESRD patients compared to the general population. The Framingham risk equation seems not to be valid in chronic uremia. Furthermore, ...<br/><br/>Adrian Covic, Paul Gusbeth-Tatomir, David J A Goldsmith (2003) <i>J Nephrol</i> <i></i> <i></i> 16: 4 476-486<br/>

http://publicationslist.org/david.goldsmith/refid88 2008-05-11T21:23:14Z

Endogenous Aspergillus endophthalmitis (AE) is a rare complication of invasive aspergillosis (IA) in transplant patients. In this report, we describe two patients with polycystic kidney disease, who developed AE with cerebral involvement after renal transplantation. Both patients received intense immunosuppression with methyl prednisolone and mycophenolate mofitil (MMF) because of persistent rejec...<br/><br/>S Schelenz, D J A Goldsmith (2003) <i>J Infect</i> <i></i> <i></i> 47: 4 336-343<br/>

http://publicationslist.org/david.goldsmith/refid98 2008-05-11T21:23:14Z

Page kidney was first described in animal experiments in 1939. In the 1950s and 1960s the human counterpart became evident. In this review we examine the modest literature on this rare but important renal/urological complication, summarize the clinical features, and discuss the best approach to diagnosis and management.<br/><br/>Ali Haydar, Rashed S Bakri, Matthew Prime, David J A Goldsmith (2003) <i>J Nephrol</i> <i></i> <i></i> 16: 3 329-333<br/>

http://publicationslist.org/david.goldsmith/refid104 2008-05-11T21:23:14Z

Renal stones rarely complicate renal transplants. Their causation is diverse. We describe 2 patients with significant staghorn calculi caused by metabolic factors.<br/><br/>S A Jayawardene, D J A Goldsmith (2003) <i>Clin Nephrol</i> <i></i> <i></i> 59: 3 222-224<br/>

http://publicationslist.org/david.goldsmith/refid106 2008-05-11T21:23:14Z

Blood glucose monitoring is important in optimizing long-term outcomes in diabetic patients. Reliance on near-patient testing and the use of longer term measures of glycation are the current cornerstones. However, as this review details, there are significant problems using blood tests as measures of metabolic control in uremic diabetic patients.<br/><br/>Adeel Ansari, Stephen Thomas, David Goldsmith (2003) <i>Am J Kidney Dis</i> <i></i> <i></i> 41: 3 523-531<br/>

http://publicationslist.org/david.goldsmith/refid107 2008-05-11T21:23:14Z

An overweight 56-year-old type II diabetic on peritoneal dialysis (body mass index 35 kg/m(2)) was taking Orlistat for some months up until live-unrelated renal transplantation. Despite oral cyclosporin A (CyA) for 48 hours pretransplantation, it was very difficult to achieve adequate CyA blood levels for the first week postengraftment despite the use of much larger oral CyA doses. After opening h...<br/><br/>Sally Evans, Robson Michael, Hayley Wells, Douglas Maclean, Isabel Gordon, John Taylor, David Goldsmith (2003) <i>Am J Kidney Dis</i> <i></i> <i></i> 41: 2 493-496<br/>

http://publicationslist.org/david.goldsmith/refid103 2008-05-11T21:23:14Z

Posterior Leukoencephalopathy Syndrome (PLES) is a rare but serious neurological condition with many aetiologies. In the era of organ transplantation there have been sporadic reports of calcineurin-inhibitor associated PLES. We describe a case, with subsequent uneventful retransplantation using sirolimus.<br/><br/>B Afzali, D J A Goldsmith (2003) <i>Clin Nephrol</i> <i></i> <i></i> 59: 3 225-228<br/>

http://publicationslist.org/david.goldsmith/refid105 2008-05-11T21:23:14Z

Thrombotic microangiopathy is a rare but important finding in the context of organ transplantation. Acute renal insufficiency in the setting of hemolysis and thrombocytopenia, a triad that constitutes 'hemolytic uremic syndrome', can be associated with, or triggered by, conditions such as verocytotoxin-producing Escherichia coli, viral infections, malignant hypertension, scleroderma, allograft rej...<br/><br/>Michael Robson, Isabelle Côte, Ian Abbs, Geoffrey Koffman, David Goldsmith (2003) <i>Am J Transplant</i> <i></i> <i></i> 3: 3 324-327<br/>

http://publicationslist.org/david.goldsmith/refid102 2008-05-11T21:23:14Z

Cushing's syndrome is characterised by circulating steroid excess; the mainstay of treatment of systemic sarcoidosis is steroid therapy. We describe a case of sarcoidosis emerging after treatment for Cushing's syndrome.<br/><br/>S Holiday, D J A Goldsmith (2003) <i>Int J Clin Pract</i> <i></i> <i></i> 57: 3 241-242<br/>

http://publicationslist.org/david.goldsmith/refid99 2008-05-11T21:23:14Z

Rashed Bakri, Cormac Breen, Douglas Maclean, John Taylor, David Goldsmith (2003) <i>Transpl Int</i> <i></i> <i></i> 16: 6 441-443<br/>

http://publicationslist.org/david.goldsmith/refid100 2008-05-11T21:23:14Z

Acute muscle infarction in diabetic patients on dialysis has rarely been reported. We present a small case series of 4 patients with unusally "inflammatory" presentations that caused diagnostic challenges. Diabetic muscle infarction should be in the differential diagnosis of acutely swollen lower limbs in dialysis patients.<br/><br/>Narbeh Melikian, John Bingham, David J A Goldsmith (2003) <i>Am J Kidney Dis</i> <i></i> <i></i> 41: 6 1322-1326<br/>

http://publicationslist.org/david.goldsmith/refid101 2008-05-11T21:23:14Z

BACKGROUND: Renal involvement [as acute renal failure (ARF)] is a prominent feature of both mild and severe leptospirosis-a re-emerging infectious disease. Few large series describe in detail clinical and laboratory features of cases with ARF and their outcome. METHODS: We performed a retrospective analysis (1997-2001) of all consecutive, serological confirmed leptospirosis cases with ARF (n=58, 5...<br/><br/>Adrian Covic, David J A Goldsmith, Paul Gusbeth-Tatomir, Anca Seica, Maria Covic (2003) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 18: 6 1128-1134<br/>

http://publicationslist.org/david.goldsmith/refid116 2008-05-11T21:23:14Z

Ambulatory blood pressure monitoring has been steadily growing in popularity as equipment becomes more accurate, affordable, and patient-friendly. In addition, software packages are more powerful and physician-customizable, and more physicians are accepting of ambulatory blood pressure monitoring's advantages. Summarizing the studies that deal mainly with hemodialysis patients, there are clear adv...<br/><br/>Adrian Covic, David J A Goldsmith (2002) <i>Curr Hypertens Rep</i> <i></i> <i></i> 4: 5 369-376<br/>

http://publicationslist.org/david.goldsmith/refid115 2008-05-11T21:23:14Z

M Chak, M R Stanford, W Poon, E M Graham, M F Tungekar, D Goldsmith (2002) <i>Br J Ophthalmol</i> <i></i> <i></i> 86: 10 1188-1190<br/>

http://publicationslist.org/david.goldsmith/refid117 2008-05-11T21:23:14Z

BACKGROUND: The efficacy of allopurinol in autosomal dominant familial juvenile hyperuricaemic nephropathy (FJHN) has been disputed. AIM: To address this question, in the absence of controlled trials. DESIGN:Retrospective long-term follow-up study. METHODS: All kindreds were biochemically screened. Measurements included uric acid clearance, creatinine clearance, serum creatinine, and glomerular fi...<br/><br/>L D Fairbanks, J S Cameron, G Venkat-Raman, S P A Rigden, L Rees, W Van'T Hoff, M Mansell, J Pattison, D J A Goldsmith, H A Simmonds (2002) <i>QJM</i> <i></i> <i></i> 95: 9 597-607<br/>

http://publicationslist.org/david.goldsmith/refid120 2008-05-11T21:23:14Z

Microscopic polyangiitis (MPA), or microscopic polyarteritis, is an idiopathic small vessel vasculitis that frequently causes glomerular damage and renal failure and skin and lung damage in many cases. The renal lesions include focal necrotizing glomerulonephritis, extracapillary proliferative (crescentic) glomerulonephritis, and tubulointerstitial infiltration with polymorphonuclear leukocytes an...<br/><br/>Martin Plaisance, David J A Goldsmith (2002) <i>Am J Kidney Dis</i> <i></i> <i></i> 39: 5 1113-1117<br/>

http://publicationslist.org/david.goldsmith/refid114 2008-05-11T21:23:14Z

Adrian Covic, David Goldsmith (2002) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 17: 10 1737-1741<br/>

http://publicationslist.org/david.goldsmith/refid119 2008-05-11T21:23:14Z

David Goldsmith, Robert MacGinley, Andrew Smith, Adrian Covic (2002) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 17: 6 965-969<br/>

http://publicationslist.org/david.goldsmith/refid118 2008-05-11T21:23:14Z

Amyloidosis frequently affects the kidney leading to proteinuria and loss of function. In cases of AA (reactive/inflammatory) amyloidosis, it is sometimes possible to quench the stimulus to chronic inflammation and by so doing stop further elaboration and deposition of amyloid fibrils. We describe the case of a man with a long-standing empyema who developed nephrotic syndrome and renal impairment....<br/><br/>H Brown, P Luce, J Dussek, J E Scoble, D J A Goldsmith (2002) <i>Am J Nephrol</i> <i></i> <i></i> 22: 4 394-396<br/>

http://publicationslist.org/david.goldsmith/refid121 2008-05-11T21:23:14Z

Oedema is the commonest presenting symptom and sign in nephrotic syndrome. Hypercholesterolaemia, thromboembolic events, and infectious complications may also be features. Three patients are described, each of whose nephrotic syndrome presented with a less common symptom or sign--recurrent pleural effusion, hypercholesterolaemia and oedema, pulmonary embolism--and, as a result, experienced some di...<br/><br/>S A Jayawardene, J E Scoble, D J A Goldsmith (2002) <i>Int J Clin Pract</i> <i></i> <i></i> 56: 2 129-131<br/>

http://publicationslist.org/david.goldsmith/refid109 2008-05-11T21:23:14Z

Ronak Rajani, John Smyth, C Geoff Koffman, Ian Abbs, David J A Goldsmith (2002) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 17: 12 2278-2280<br/>

http://publicationslist.org/david.goldsmith/refid113 2008-05-11T21:23:14Z

Satishkumar A Jayawardene, David J A Goldsmith (2002) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 17: 10 1832-1835<br/>

http://publicationslist.org/david.goldsmith/refid110 2008-05-11T21:23:14Z

BACKGROUND: HD has been reported to determine an increase in QTc interval and QTc dispersion (QT(max)-QT(min))-risk factors that predispose to severe ventricular arrhythmias and sudden death. However, most studies have included end-stage renal disease (ESRD) patients with significant heart pathology. We therefore aimed to study the impact of a single HD session in subjects without manifest cardiac...<br/><br/>Adrian Covic, Mirela Diaconita, Paul Gusbeth-Tatomir, Maria Covic, Adrian Botezan, Gabriel Ungureanu, David J Goldsmith (2002) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 17: 12 2170-2177<br/>

http://publicationslist.org/david.goldsmith/refid108 2008-05-11T21:23:14Z

BACKGROUND: Diurnal BP rhythm is known to be abnormal (reduced BP fall with sleep) in chronic renal failure, dialysis and renal transplantation patients. In subjects with primary hypertension and with reduced diurnal BP fall with sleep there is consistent evidence of increased target-organ damage. However, the few studies that have addressed the reproducibility of diurnal rhythm in normal or hyper...<br/><br/>Adrian Covic, Irina Mititiuc, Paul Gusbeth-Tatomir, David J Goldsmith (2002) <i>J Nephrol</i> <i></i> <i></i> 15: 5 497-506<br/>

http://publicationslist.org/david.goldsmith/refid112 2008-05-11T21:23:14Z

Coronary artery disease is very frequent in dialysis patients, and influences their survival while on dialysis and even after renal transplantation. There are problems with screening tools in that they have reduced sensitivity and specificity in the uraemic individual. There is a real need for additional and complementary markers of coronary disease in these patients. We discuss some novel ideas f...<br/><br/>J Smyth, R S Bakri, A Covic, D J A Goldsmith (2002) <i>Minerva Urol Nefrol</i> <i></i> <i></i> 54: 3 157-162<br/>

http://publicationslist.org/david.goldsmith/refid111 2008-05-11T21:23:14Z

BACKGROUND: Icodextrin is a new peritoneal dialysis fluid, with maltose polymers providing the osmotic drive, that may extend time on peritoneal dialysis in situations in which use of conventional glucose-based peritoneal dialysis fluid (Dianeal) has led to loss of ultrafiltration. Although cutaneous reactions have been reported, we report a new phenomenon of aseptic peritonitis that has arisen in...<br/><br/>Robert MacGinley, Katrina Cooney, Geraldine Alexander, SueMien Cohen, David J A Goldsmith (2002) <i>Am J Kidney Dis</i> <i></i> <i></i> 40: 5 1030-1035<br/>

http://publicationslist.org/david.goldsmith/refid128 2008-05-11T21:28:44Z

Cardiovascular disease is prevalent in patients with advanced renal failure or on dialysis treatment, and after renal transplantation. The risk factors for the cardiovascular problems are a mixture of conventional and novel ones. Inflammation and oxidation may be especially important in the acceleration of atherosclerosis in chronic renal failure. This article discusses these factors and gathers t...<br/><br/>D J Goldsmith, A Covic (2001) <i>Int J Clin Pract</i> <i></i> <i></i> 55: 3 196-210<br/>

http://publicationslist.org/david.goldsmith/refid129 2008-05-11T21:28:44Z

Malignant mesothelioma can present insidiously with progressive breathlessness and chest pain. Paraneoplastic, or non-chest related, presentations are very rare. The case of an elderly man with occupational exposure to asbestos who presented with nephrotic syndrome due to minimal change nephropathy in the context of advanced pleural mesothelial malignancy is reported.<br/><br/>C K Farmer, D J Goldsmith (2001) <i>Postgrad Med J</i> <i></i> <i></i> 77: 907 333-334<br/>

http://publicationslist.org/david.goldsmith/refid132 2008-05-11T21:28:44Z

S Uppal, N Saravanappa, J P Davis, C K Farmer, D J Goldsmith (2001) <i>BMJ</i> <i></i> <i></i> 322: 7278 89-90<br/>

http://publicationslist.org/david.goldsmith/refid127 2008-05-11T21:28:44Z

R Masterson, N Sheerin, I Abbs, D Goldsmith (2001) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 16: 8 1705-1707<br/>

http://publicationslist.org/david.goldsmith/refid27 2008-05-11T21:23:14Z

Both rheumatoid vasculitis and amyloidosis in rheumatoid arthritis (RA) are uncommon. We describe a patient in whom they occurred together and were associated with fatal intra-abdominal hemorrhage. A 56-year-old Caucasian woman was referred because of increasing lethargy, edema, and proteinuria. She had suffered from seropositive, erosive, nodular RA for 14 years. Previously, she had undergone num...<br/><br/>S A Jayawardene, N Sheerin, J M Pattison, B Hartley, D J Goldsmith (2001) <i>J Clin Rheumatol</i> <i></i> <i></i> 7: 2 86-90<br/>

http://publicationslist.org/david.goldsmith/refid130 2008-05-11T21:28:44Z

D Goldsmith (2001) <i>J Hum Hypertens</i> <i></i> <i></i> 15: 3 147-151<br/>

http://publicationslist.org/david.goldsmith/refid126 2008-05-11T21:28:44Z

Hyperparathyroidism is a common problem for patients on renal replacement therapy programs. Many long-term dialysis patients require parathyroidectomy while on dialysis. Some patients, however, despite severe renal osteodystrophy, are transplanted, and in these a large proportion show a slow resolution of bony problems, in the context of the removal of the uremic stimulus to abnormal bone metaboli...<br/><br/>D Goldsmith, W J Owen (2001) <i>Nephron</i> <i></i> <i></i> 89: 1 105-107<br/>

http://publicationslist.org/david.goldsmith/refid123 2008-05-11T21:23:14Z

Cardiovascular disease is a major challenge to nephrologists, whether we deal with patients with pre-end-stage renal failure, on dialysis or after successful renal transplantation. It is the most common cause for death in patients with a functional allograft, and prevents many dialysis patients from being engrafted. Coronary artery disease is a diagnostic and therapeutic challenge, as it differs i...<br/><br/>D J Goldsmith, A Covic (2001) <i>Kidney Int</i> <i></i> <i></i> 60: 6 2059-2078<br/>

http://publicationslist.org/david.goldsmith/refid122 2008-05-11T21:23:14Z

D J Goldsmith, M M Black (2001) <i>J Eur Acad Dermatol Venereol</i> <i></i> <i></i> 15: 5 392-398<br/>

http://publicationslist.org/david.goldsmith/refid124 2008-05-11T21:23:14Z

A C Covic, D J Goldsmith, L Florea, P Gusbeth, C Volovat, T Taranu, N Suditu, C Novac, M Covic (2001) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 16: 10 1996-2001<br/>

http://publicationslist.org/david.goldsmith/refid125 2008-05-11T21:23:14Z

AIM: Diabetes is now the commonest cause of end-stage renal failure, so there are many diabetic patients receiving dialysis therapy. There are several important ways in which dialysis practice can impinge unfavourably on glucose control. This study focuses on the interaction between maltose-derived metabolites in a new peritoneal dialysis fluid and blood glucose measurements using reagent sticks t...<br/><br/>S Mehmet, G Quan, S Thomas, D Goldsmith (2001) <i>Diabet Med</i> <i></i> <i></i> 18: 8 679-682<br/>

http://publicationslist.org/david.goldsmith/refid139 2008-05-11T21:28:44Z

M Melzer, D Goldsmith, W Gransden (2000) <i>Clin Infect Dis</i> <i></i> <i></i> 31: 1 208-209<br/>

http://publicationslist.org/david.goldsmith/refid140 2008-05-11T21:28:44Z

BACKGROUND: Arterial stiffening is very pronounced in renal patients. Carotid artery stiffening is a powerful predictor of future cardiovascular mortality, and measures of arterial compliance correlate much better with left ventricular mass (LVM) in dialysis patients than does brachial artery blood pressure (BP). The aim of our study was to describe the influence of a hemodialysis (HD) session on ...<br/><br/>A Covic, D J Goldsmith, L Panaghiu, M Covic, J Sedor (2000) <i>Kidney Int</i> <i></i> <i></i> 57: 6 2634-2643<br/>

http://publicationslist.org/david.goldsmith/refid143 2008-05-11T21:28:44Z

D J Goldsmith, A Covic (2000) <i>Am J Kidney Dis</i> <i></i> <i></i> 35: 2 361-362<br/>

http://publicationslist.org/david.goldsmith/refid145 2008-05-11T21:28:44Z

D Goldsmith, A Cork (2000) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 15: 1 131-132<br/>

http://publicationslist.org/david.goldsmith/refid138 2008-05-11T21:28:44Z

D J Goldsmith, C K Farmer (2000) <i>J R Soc Med</i> <i></i> <i></i> 93: 7 377-378<br/>

http://publicationslist.org/david.goldsmith/refid142 2008-05-11T21:28:44Z

Cardiovascular mortality places a considerable burden on chronic renal replacement therapy programs. Left ventricular hypertrophy (LVH) increases the risk for cardiovascular mortality. Risk factors for LVH in the dialysis population are numerous and include arterial distensibility, hypertension, anemia, arteriovenous fistula, and hyperparathyroidism. An important factor to consider in the diagnosi...<br/><br/>A Covic, D J Goldsmith, M Covic (2000) <i>Am J Kidney Dis</i> <i></i> <i></i> 35: 4 617-623<br/>

http://publicationslist.org/david.goldsmith/refid136 2008-05-11T21:28:44Z

Atherosclerotic renal arterial disease (ARAD) is becoming a more important cause of end-stage renal failure. Diagnosis is more easily achieved because of greater clinical suspicion and more refined screening tools. However, the medical and interventional management of patients with ARAD is not well defined in the literature because there have been few randomized trials. Because the use of angioten...<br/><br/>D J Goldsmith, J Reidy, J Scoble (2000) <i>Am J Kidney Dis</i> <i></i> <i></i> 36: 4 837-843<br/>

http://publicationslist.org/david.goldsmith/refid133 2008-05-11T21:28:44Z

Emphysematous pyelonephritis most often presents as an acute medical emergency, typically in a septic diabetic patient with acute renal failure. The management of this condition has traditionally been surgical, with nephrectomy. However, some recent reports have described successful medical interventions. We describe a case of acute bilateral emphysematous pyelonephritis in a frail patient not sui...<br/><br/>H Tahir, G Thomas, N Sheerin, H Bettington, J M Pattison, D J Goldsmith (2000) <i>Am J Kidney Dis</i> <i></i> <i></i> 36: 6 1267-1270<br/>

http://publicationslist.org/david.goldsmith/refid131 2008-05-11T21:28:44Z

A new glucoee polymer, icodextrin, related to maltose, is in increasing use as a peritoneal dialysis fluid. We report on adverse events seen in our unit during a 12-month period after the introduction of this reagent.<br/><br/>D Goldsmith, S Jayawardene, N Sabharwal, K Cooney (2000) <i>Lancet</i> <i></i> <i></i> 355: 9207 <br/>

http://publicationslist.org/david.goldsmith/refid137 2008-05-11T21:28:44Z

D Goldsmith (2000) <i>Kidney Int</i> <i></i> <i></i> 58: 3 <br/>

http://publicationslist.org/david.goldsmith/refid134 2008-05-11T21:28:44Z

Spinal osteomyelitis is a recognized complication in dialysis patients related to hematogenous spread of infection during bacteremia-septicemia. These episodes are often associated with sepsis due to temporary dialysis access. We describe the case of an unfortunate man whose osteomyelitis was located in the posterior facet joints. Such infection is rare and in the reviewed literature is usually as...<br/><br/>M J Dayer, W Gransden, D J Goldsmith (2000) <i>Am J Kidney Dis</i> <i></i> <i></i> 36: 5 1041-1044<br/>

http://publicationslist.org/david.goldsmith/refid135 2008-05-11T21:28:44Z

A 75-year-old woman who had been receiving dialysis for 3 years and had a long history of chronic renal failure attributable to reflux nephropathy was investigated for progressive hypercalcemia in the context of very high intact parathormone (iPTH) levels. Imaging showed two functional parathyroid glands in the neck. At parathyroidectomy, four variously enlarged parathyroid glands were found and c...<br/><br/>S Jayawardene, W J Owen, D J Goldsmith (2000) <i>Am J Kidney Dis</i> <i></i> <i></i> 36: 4 <br/>

http://publicationslist.org/david.goldsmith/refid148 2008-05-11T21:28:44Z

D J Goldsmith, P Thomas (1999) <i>N Engl J Med</i> <i></i> <i></i> 340: 24 <br/>

http://publicationslist.org/david.goldsmith/refid147 2008-05-11T21:28:44Z

Bullous dermatoses (BD) are well recognized in patients with end-stage renal disease (ESRD). It is important to distinguish pseudoporphyria (porphyrin accumulation due to decreased clearance) from true porphyrias, particularly those in which acute neurological attacks may occur. Investigation of the dialysis patient poses practical diagnostic difficulties because urinary porphyrin profiles are not...<br/><br/>P Glynne, A Deacon, D Goldsmith, C Pusey, E Clutterbuck (1999) <i>Am J Kidney Dis</i> <i></i> <i></i> 34: 1 155-160<br/>

http://publicationslist.org/david.goldsmith/refid146 2008-05-11T21:28:44Z

As accurate assessment of hypertension in renal patients must be the cornerstone of better prevention of its deleterious effects, ambulatory blood pressure monitoring (ABPM) has become an essential clinical and research procedure in day to day nephrological practice. However, despite numerous studies in the renal literature, a consensus is needed for normal (desirable?!) ambulatory daytime and nig...<br/><br/>A Covic, D J Goldsmith (1999) <i>J Nephrol</i> <i></i> <i></i> 12: 4 220-229<br/>

http://publicationslist.org/david.goldsmith/refid144 2008-05-11T21:28:44Z

Two hundred and eighty-six patients (190 males and 96 females) with end-stage renal failure (ESRD) started haemodialysis (HD) at Withington Hospital between 1 January 1968 and 31 December 1986. Of these, 152 (53.1%) were successfully transplanted, while 134 had only HD or one transplant lasting < 3 months (i.e. total HD interruption < 3 months). For the whole group, the probabilities of being aliv...<br/><br/>A Covic, D J Goldsmith, M C Venning, P Ackrill (1999) <i>QJM</i> <i></i> <i></i> 92: 5 251-260<br/>

http://publicationslist.org/david.goldsmith/refid141 2008-05-11T21:28:44Z

Abnormalities (reduction in/absence of) in diurnal bp rhythm are much more commonly seen in patients with chronic uremia than in patients with primary hypertension or in normal subjects. Target-organ damage is greater in these patients. However, the extent to which these diurnal bp rhythm changes are consistent or variable is untested. We retrospectively examined 223 ambulatory blood pressure moni...<br/><br/>A Covic, D J Goldsmith, C K Farmer, J Cox, P Dallyn, P Sharpstone, J C Kingswood (1999) <i>Rev Med Chir Soc Med Nat Iasi</i> <i></i> <i></i> 103: 1-2 88-93<br/>

http://publicationslist.org/david.goldsmith/refid156 2008-05-11T21:28:44Z

BACKGROUND: Hypertensive non-diabetic patients who lack the normal nocturnal decline in blood pressure ('non-dippers') have an increased incidence of cardiovascular complications. Poor blood pressure control is known to exacerbate the decline in glomerular filtration rate in patients with diabetic nephropathy. METHODS: The aim of this study was to assess the contribution of abnormal blood pressure...<br/><br/>C K Farmer, D J Goldsmith, J D Quin, P Dallyn, J Cox, J C Kingswood, P Sharpstone (1998) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 13: 3 635-639<br/>

http://publicationslist.org/david.goldsmith/refid158 2008-05-11T21:28:44Z

A case report of a 50-year-old woman who has been treated with peritoneal dialysis for 9 years, with a short period off dialysis following transplantation. The patient had long-standing secondary hyperparathyroidism and had declined parathyroidectomy, she had had two episodes of peritonitis in the preceding eight years. She presented with blood-stained dialysate effluent and intermittent abdominal...<br/><br/>C K Farmer, D J Goldsmith, P Sharpstone, J C Kingswood (1998) <i>Clin Nephrol</i> <i></i> <i></i> 49: 1 55-58<br/>

http://publicationslist.org/david.goldsmith/refid159 2008-05-11T21:28:44Z

D J Goldsmith (1998) <i>Lancet</i> <i></i> <i></i> 351: 9100 447; author reply 447-447; author reply 448<br/>

http://publicationslist.org/david.goldsmith/refid154 2008-05-11T21:28:44Z

OBJECTIVE: Turner's syndrome (TS) is a disorder associated with characteristic defects in the X chromosome. Autoimmune conditions such as thyroiditis, inflammatory bowel diseases and diabetes have been described in association with TS. METHODS: We have studied the association between TS and juvenile arthritis (JA) by using a survey in which 28 pediatric rheumatology centers (15 in the USA, 10 in E...<br/><br/>F Zulian, H R Schumacher, A Calore, D P Goldsmith, B H Athreya (1998) <i>Clin Exp Rheumatol</i> <i></i> <i></i> 16: 4 489-494<br/>

http://publicationslist.org/david.goldsmith/refid155 2008-05-11T21:28:44Z

BACKGROUND: Since 1971, 55 case-reports of rifampicin-induced ARF have been published, but systematic data on this condition are not available, in view of the disparate nature of the observations. METHODS: We retrospectively assessed prevalence, clinical and biochemical features, and prognostic factors of 60 consecutive cases (41 males/19 females, age 22-68 years), who were admitted to the Iasi Di...<br/><br/>A Covic, D J Goldsmith, L Segall, C Stoicescu, S Lungu, C Volovat, M Covic (1998) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 13: 4 924-929<br/>

http://publicationslist.org/david.goldsmith/refid150 2008-05-11T21:28:44Z

BACKGROUND: Longevity on dialysis is determined by many factors. One of these has increasingly been seen to be 'dialysis dose'. There are several methods for calculating dialysis dose. We wanted prospectively to test 'gold-standard' UKM-Kt/V with various shortcut bedside formulae, to see whether reliance on the latter approach was likely to lead to errors in over- or underprescribing dialysis regi...<br/><br/>A Covic, D J Goldsmith, K Hill, M C Venning, P Ackrill (1998) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 13: 12 3138-3146<br/>

http://publicationslist.org/david.goldsmith/refid149 2008-05-11T21:28:44Z

D Goldsmith (1998) <i>J R Soc Med</i> <i></i> <i></i> 91: 11 <br/>

http://publicationslist.org/david.goldsmith/refid153 2008-05-11T21:28:44Z

D J Goldsmith, G Hamilton (1998) <i>Postgrad Med J</i> <i></i> <i></i> 74: 871 263-265<br/>

http://publicationslist.org/david.goldsmith/refid151 2008-05-11T21:28:44Z

Three out of four patients with primary (light chain) amyloid nephrotic syndrome treated with vincristine, doxorubicin and dexamethasone (VAD) induction obtained a partial response and are alive in continuing remission at 4.1, 6.5 and 9.3 years. These preliminary results are of considerable interest and suggest that prospective evaluation of this regimen is warranted in patients with this conditio...<br/><br/>A M Wardley, G C Jayson, D J Goldsmith, M C Venning, P Ackrill, J H Scarffe (1998) <i>Br J Cancer</i> <i></i> <i></i> 78: 6 774-776<br/>

http://publicationslist.org/david.goldsmith/refid152 2008-05-11T21:28:44Z

D J Goldsmith (1998) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 13: 8 2164-2166<br/>

http://publicationslist.org/david.goldsmith/refid166 2008-05-11T21:28:44Z

D J Goldsmith (1997) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 12: 5 1082-1083<br/>

http://publicationslist.org/david.goldsmith/refid167 2008-05-11T21:28:44Z

D J Goldsmith (1997) <i>Lancet</i> <i></i> <i></i> 349: 9060 <br/>

http://publicationslist.org/david.goldsmith/refid168 2008-05-11T21:28:44Z

Blood pressure (BP) elevation and left ventricular hypertrophy are important factors in the high cardiovascular mortality rate in patients on the renal replacement program. Ambulatory BP monitoring is widely regarded as superior to random BP monitoring in predicting end-organ damage from elevated BP. One hundred seventeen patients (60 on hemodialysis [35 with long sessions and 25 with short sessio...<br/><br/>D J Goldsmith, A C Covic, M C Venning, P Ackrill (1997) <i>Am J Kidney Dis</i> <i></i> <i></i> 29: 4 593-600<br/>

http://publicationslist.org/david.goldsmith/refid170 2008-05-11T21:28:44Z

Vascular calcification (VC), which is described in the elderly and in diabetics, is frequently seen in uraemia. It is usually regarded as having little significance. We studied the roentgenological appearance of VC in a homogeneous group of 38 long-hours haemodialysis patients whose longevity on dialysis allowed sustained (10-25 years) follow-up, including annual skeletal surveys and thrice-yearly...<br/><br/>D J Goldsmith, A Covic, P A Sambrook, P Ackrill (1997) <i>Nephron</i> <i></i> <i></i> 77: 1 37-43<br/>

http://publicationslist.org/david.goldsmith/refid165 2008-05-11T21:28:44Z

D J Goldsmith (1997) <i>Lancet</i> <i></i> <i></i> 350: 9080 <br/>

http://publicationslist.org/david.goldsmith/refid169 2008-05-11T21:28:44Z

A 56-year-old man who received a live-related renal transplant in 1988 was started in 1995 on the selective angiotensin II antagonist losartan (Dupont-Merke) to treat worsening hypertension. Two months later because of pulmonary oedema, loop diuretics were started. Within two weeks, serum creatinine had increased from 245 to 571 mumol/l, and the patient became oliguric. A systolic bruit was noted ...<br/><br/>M Ostermann, D J Goldsmith, T Doyle, J C Kingswood, P Sharpstone (1997) <i>Postgrad Med J</i> <i></i> <i></i> 73: 856 105-107<br/>

http://publicationslist.org/david.goldsmith/refid160 2008-05-11T21:28:44Z

D J Goldsmith (1997) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 12: 12 2793-2794<br/>

http://publicationslist.org/david.goldsmith/refid164 2008-05-11T21:28:44Z

OBJECTIVE: To determine the prevalence and outcome of chronic uveitis in patients with juvenile rheumatoid arthritis (JRA). METHODS: A retrospective analysis of 760 patients with JRA followed in 4 pediatric rheumatology centers. Patients with chronic uveitis were identified and their medical and ophthalmologic records were reviewed. RESULTS: Seventy-four patients with uveitis were identified. The ...<br/><br/>E C Chalom, D P Goldsmith, M A Koehler, B Bittar, C D Rose, B E Ostrov, G F Keenan (1997) <i>J Rheumatol</i> <i></i> <i></i> 24: 10 2031-2034<br/>

http://publicationslist.org/david.goldsmith/refid161 2008-05-11T21:28:44Z

D J Goldsmith (1997) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 12: 11 2463-2464<br/>

http://publicationslist.org/david.goldsmith/refid157 2008-05-11T21:28:44Z

1. The correction of metabolic acidosis with sodium bicarbonate remains controversial. Experiments in vitro have suggested possible deleterious effects after alkalinization of the extracellular fluid. Disequilibrium of carbon dioxide and bicarbonate across cell membranes after alkali administration, leading to the phenomenon of 'paradoxical' intracellular acidosis, has been held responsible for so...<br/><br/>D J Goldsmith, L G Forni, P J Hilton (1997) <i>Clin Sci (Lond)</i> <i></i> <i></i> 93: 6 593-598<br/>

http://publicationslist.org/david.goldsmith/refid162 2008-05-11T21:28:44Z

BACKGROUND: Ambulatory blood pressure recordings have been shown to correlate better with target organ damage than have isolated clinic blood pressure readings. There have been some small studies demonstrating that abnormal blood pressure diurnal rhythm is common in uraemia and in patients on renal replacement therapy. Abnormal blood pressure diurnal rhythm itself may be a risk factor for accelera...<br/><br/>C K Farmer, D J Goldsmith, J Cox, P Dallyn, J C Kingswood, P Sharpstone (1997) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 12: 11 2301-2307<br/>

http://publicationslist.org/david.goldsmith/refid163 2008-05-11T21:28:44Z

C K Farmer, E Greenwood, D J Goldsmith, J C Kingswood, P Sharpstone (1997) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 12: 9 <br/>

http://publicationslist.org/david.goldsmith/refid179 2008-05-11T21:28:44Z

This article describes the echocardiographic structural and functional findings in a cohort of 30 patients on ten or more years of uninterrupted long-hour (24 hours per week dialysis schedule) hemodialysis (mean duration 187.7 months, range 120 to 299 months). Cardiac structural analysis was remarkable for the prevalence of LVH (76%), very rarely asymmetric (3%). Hemoglobin and (log) plasma renin ...<br/><br/>A Covic, D J Goldsmith, G Georgescu, M C Venning, P Ackrill (1996) <i>Clin Nephrol</i> <i></i> <i></i> 45: 2 104-110<br/>

http://publicationslist.org/david.goldsmith/refid180 2008-05-11T21:28:44Z

D J Goldsmith, A Covic, P Ackrill (1996) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 11: 2 401-402<br/>

http://publicationslist.org/david.goldsmith/refid181 2008-05-11T21:28:44Z

This study was performed to evaluate prognostic factors in ADPKD progression to ERSF. Previously reported negative factors (male gender, age, hypertension, palpable kidneys and UTI) as well as the extra-renal presence of cysts and proteinuria, were analysed in a group of 45 ADPKD patients (Male/Female, 25/20; Age = 40.1 +/- 19.7 yrs, range 21-69). Palpable kidneys were associated with higher serum...<br/><br/>A Covic, I Mititiuc, D J Goldsmith, M Covic (1996) <i>Rev Med Chir Soc Med Nat Iasi</i> <i></i> <i></i> 100: 1-2 78-84<br/>

http://publicationslist.org/david.goldsmith/refid183 2008-05-11T21:28:44Z

A Covic, D J Goldsmith, P Sambrook, M C Venning, P Ackrill (1996) <i>Contrib Nephrol</i> <i></i> <i></i> 119: 157-160<br/>

http://publicationslist.org/david.goldsmith/refid185 2008-05-11T21:28:44Z

The proportion of patients with vasculitis and rapidly progressive nephritis aged 70 years or over has risen from about 10% in the 1980s to over 30% in series reported in the 1990s. This study was undertaken to examine the presentation and outcome of such older patients. Seventeen of 56 patients (30%) who presented at two renal units were aged 70 years or over. Mean creatinine level at presentatio...<br/><br/>R M Higgins, D J Goldsmith, J Connolly, J E Scoble, B M Hendry, P Ackrill, M C Venning (1996) <i>Postgrad Med J</i> <i></i> <i></i> 72: 843 41-44<br/>

http://publicationslist.org/david.goldsmith/refid184 2008-05-11T21:28:44Z

P Donohoe, D de Takats, N Bishop, R J Burwood, T Doyle, D Goldsmith, G Hamilton, I Kenney, J C Kingswood, P Sharpstone (1996) <i>Contrib Nephrol</i> <i></i> <i></i> 119: 78-82<br/>

http://publicationslist.org/david.goldsmith/refid182 2008-05-11T21:28:44Z

Systemic amyloidosis normally has a dismal prognosis. However, there are several case reports of protracted survival, usually as a response to measures designed to retard the further deposition of amyloid fibrils. In AA amyloid, most commonly associated with inflammatory rheumatological, bowel, and chest diseases, such interventions have had some success, but the dramatic response of complete reso...<br/><br/>D J Goldsmith, I S Roberts, C D Short, N P Mallick (1996) <i>Nephron</i> <i></i> <i></i> 74: 3 572-576<br/>

http://publicationslist.org/david.goldsmith/refid178 2008-05-11T21:28:44Z

D J Goldsmith (1996) <i>Am J Med</i> <i></i> <i></i> 100: 4 481-482<br/>

http://publicationslist.org/david.goldsmith/refid172 2008-05-11T21:28:44Z

AL-amyloidosis has a poor prognosis, typically with cardiac or renal failure ensuing some months after diagnosis. However, sporadically there have been reports of long-term survivors, either with unusual manifestations of amyloidosis, or after concerted chemotherapy to suppress the overt or occult pathological monoclonal plasma cell population responsible for the elaboration of immunoglobulin ligh...<br/><br/>D J Goldsmith, D Sandooran, C D Short, N P Mallick, R W Johnson (1996) <i>Am J Kidney Dis</i> <i></i> <i></i> 28: 2 278-282<br/>

http://publicationslist.org/david.goldsmith/refid171 2008-05-11T21:28:44Z

A Covic, I Mititiuc, L Caruntu, D J Goldsmith (1996) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 11: 10 2074-2076<br/>

http://publicationslist.org/david.goldsmith/refid173 2008-05-11T21:28:44Z

D J Goldsmith (1996) <i>Am J Med</i> <i></i> <i></i> 101: 2 230-231<br/>

http://publicationslist.org/david.goldsmith/refid177 2008-05-11T21:28:44Z

After serious paracetamol overdose, charcoal haemoperfusion was used to remove paracetamol from the circulation, aiming to reduce the severity of subsequent hepatic damage. Daily long-hours high-flux dialysis was given to patients with grade III-IV hepatic encephalopathy, and also to those at risk of developing encephalopathy. We reviewed patients treated in this manner who had not received N-acet...<br/><br/>R M Higgins, D J Goldsmith, A MacDiarmid-Gordon, D Taberner, M C Venning, P Ackrill (1996) <i>QJM</i> <i></i> <i></i> 89: 4 297-306<br/>

http://publicationslist.org/david.goldsmith/refid174 2008-05-11T21:28:44Z

D J Goldsmith, I S Roberts, N P Mallick (1996) <i>Postgrad Med J</i> <i></i> <i></i> 72: 848 380-382<br/>

http://publicationslist.org/david.goldsmith/refid176 2008-05-11T21:28:44Z

D J Goldsmith, A Covic, P Sambrook, P Ackrill (1996) <i>Am J Med</i> <i></i> <i></i> 100: 5 587-588<br/>

http://publicationslist.org/david.goldsmith/refid175 2008-05-11T21:28:44Z

A link between plasma calcium, dietary cations, and blood pressure has been suspected for some time, with human, experimental animal, and epidemiological data adduced to support this hypothesis. We identified 21 patients receiving regular maintenance hemodialysis, but not receiving any regular antihypertensive treatment, who had undergone 22 surgical removals of the parathyroid glands in the perio...<br/><br/>D J Goldsmith, A A Covic, M C Venning, P Ackrill (1996) <i>Am J Kidney Dis</i> <i></i> <i></i> 27: 6 819-825<br/>

http://publicationslist.org/david.goldsmith/refid186 2008-05-11T21:28:44Z

Theophylline poisoning with a blood level of 183 mg/l in a 38-year-old man was treated with activated charcoal by mouth, but despite this the blood level of theophylline rose and there was circulatory collapse with rhabdomyolysis, acute renal failure and hyperthermia. Treatment with charcoal haemoperfusion and simultaneous haemodialysis was given, followed by continuous arteriovenous haemodialysis...<br/><br/>R M Higgins, S Hearing, D J Goldsmith, B Keevil, M C Venning, P Ackrill (1995) <i>Postgrad Med J</i> <i></i> <i></i> 71: 834 224-226<br/>

http://publicationslist.org/david.goldsmith/refid187 2008-05-11T21:28:44Z

Based on correlation analysis with 24-h dialysis collections the peritoneal equilibration test (PET) has been promoted as an aid to prescribe and monitor dialysis dose. However correlation is an incorrect statistical technique to demonstrate the similarity of one measure to another. The closeness (or limits) of agreement should be measured using the technique of Bland and Altman. One hundred and n...<br/><br/>J C Harty, D J Goldsmith, H Boulton, N Heelis, L Uttley, J Morris, M C Venning, R Gokal (1995) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 10: 2 252-257<br/>

http://publicationslist.org/david.goldsmith/refid190 2008-05-11T21:28:44Z

D J Goldsmith (1994) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 9: 11 1698-1699<br/>

http://publicationslist.org/david.goldsmith/refid189 2008-05-11T21:28:44Z

A 30 year old man with a 20 year history of chronic renal failure who presented with a testicular lesion is described. The lesional pathology, secondary oxalosis, and associated sperm granuloma of the epididymis was clinically considered to be an intrascrotal tumour. The oxalate crystal deposition was present within the rete testis, the ductuli efferents, and the epididymis along with sperm granul...<br/><br/>J Coyne, L al-Nakib, D Goldsmith, K O'Flynn (1994) <i>J Clin Pathol</i> <i></i> <i></i> 47: 5 470-471<br/>

http://publicationslist.org/david.goldsmith/refid188 2008-05-11T21:28:44Z

R H Mallinson, D J Goldsmith, R M Higgins, M C Venning, P Ackrill (1994) <i>BMJ</i> <i></i> <i></i> 309: 6965 1361-1362<br/>

http://publicationslist.org/david.goldsmith/refid191 2008-05-11T21:28:44Z

D J Goldsmith (1992) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 7: 7 654-655<br/>

http://publicationslist.org/david.goldsmith/refid192 2008-05-11T21:28:44Z

The cellular basis for essential hypertension remains obscure. Abnormal ion transport has been demonstrated in both experimental and essential hypertension, raised levels of sodium-lithium (Na(+)-Li+) and sodium-proton (Na(+)-H+) exchange in blood cells being a consistent feature. However, Na(+)-H+ exchange is not the main regulator of intracellular pH at resting pH, while the importance of the co...<br/><br/>D J Goldsmith, R M Tribe, L Poston, F P Cappuccio, N D Markandu, G A MacGregor, P J Hilton (1991) <i>J Hypertens</i> <i></i> <i></i> 9: 7 645-653<br/>

http://publicationslist.org/david.goldsmith/refid193 2008-05-11T21:28:44Z

1. Leucocyte Na+/H+ exchange and intracellular pH were investigated in physiological buffer containing bicarbonate. 2. The amiloride analogue 5-(N,N-hexamethylene) amiloride (1 x 10(-5) mol/l), an inhibitor of Na+/H+ exchange, had no significant effect on resting leucocyte pH, Na+ influx or Na+ content. 3. Ammonium chloride washout induced a profound intracellular acidosis, stimulating Na+/H+ exch...<br/><br/>D J Goldsmith, L Poston, M Watson, J Morris, P J Hilton, E J Cragoe (1990) <i>Clin Sci (Lond)</i> <i></i> <i></i> 79: 4 357-364<br/>

http://publicationslist.org/david.goldsmith/refid194 2008-05-11T21:28:44Z

The role of Na-H exchange in endothelin-induced contraction of human peripheral resistance vessels was investigated. Endothelin produced a dose-dependent contraction which was greatly attenuated in the presence of a low extracellular sodium concentration. Inhibition of Na-H exchange by the amiloride analogue 5-(N,N-hexamethylene) amiloride (5-NNHA) resulted in a greater than 65% relaxation of a ma...<br/><br/>N T Richards, L Poston, D J Goldsmith, E J Cragoe, P J Hilton (1989) <i>J Hypertens</i> <i></i> <i></i> 7: 10 777-780<br/>