http://publicationslist.org/data/debasis.dash/atom.xml Debasis Dashhttp://publicationslist.org/debasis.dash$basepathfavicon.icoRecent additions to Debasis Dash's PublicationsList.org pagehttp://publicationslist.org/publications.png2013-05-01T11:09:44Z http://publicationslist.org/debasis.dash/refid32 2013-04-30T07:14:43Z

Intrinsic disorder in proteins has been explored to study lack of structure-function aspects of many proteins. The current study focuses on coiled coils which are often linked to intrinsic disorder. We present a sequence level analysis of human coiled coils to find out if this is universally true for all coiled coils. When annotated coiled-coil regions were collected from UniProt and investigated ...<br/><br/>Meenakshi Anurag, Gajinder Pal Singh, Debasis Dash (2012) <i>Mol Biosyst</i> <i></i> <i></i> 8: 1 346-352<br/>

http://publicationslist.org/debasis.dash/refid35 2013-04-30T07:17:19Z

The statistical validation of database search results is a complex issue in bottom-up proteomics. The correct and incorrect peptide spectrum match (PSM) scores overlap significantly, making an accurate assessment of true peptide matches challenging. Since the complete separation between the true and false hits is practically never achieved, there is need for better methods and rescoring algorithms...<br/><br/>Amit Kumar Yadav, Dhirendra Kumar, Debasis Dash (2012) <i>PLoS One</i> <i></i> <i></i> 7: 11 <br/>

http://publicationslist.org/debasis.dash/refid34 2013-04-30T07:15:20Z

A decade since the availability of Mycobacterium tuberculosis (Mtb) genome sequence, no promising drug has seen the light of the day. This not only indicates the challenges in discovering new drugs but also suggests a gap in our current understanding of Mtb biology. We attempt to bridge this gap by carrying out extensive re-annotation and constructing a systems level protein interaction map of Mtb...<br/><br/>Rohit Vashisht, Anupam Kumar Mondal, Akanksha Jain, Anup Shah, Priti Vishnoi, Priyanka Priyadarshini, Kausik Bhattacharyya, Harsha Rohira, Ashwini G Bhat, Anurag Passi, Keya Mukherjee, Kumari Sonal Choudhary, Vikas Kumar, Anshula Arora, Prabhakaran Munusamy, Ahalyaa Subramanian, Aparna Venkatachalam, S Gayathri, Sweety Raj, Vijaya Chitra, Kaveri Verma, Salman Zaheer, J Balaganesh, Malarvizhi Gurusamy, Mohammed Razeeth, Ilamathi Raja, Madhumohan Thandapani, Vishal Mevada, Raviraj Soni, Shruti Rana, Girish Muthagadhalli Ramanna, Swetha Raghavan, Sunil N Subramanya, Trupti Kholia, Rajesh Patel, Varsha Bhavnani, Lakavath Chiranjeevi, Soumi Sengupta, Pankaj Kumar Singh, Naresh Atray, Swati Gandhi, Tiruvayipati Suma Avasthi, Shefin Nisthar, Meenakshi Anurag, Pratibha Sharma, Yasha Hasija, Debasis Dash, Arun Sharma, Vinod Scaria, Zakir Thomas, Nagasuma Chandra, Samir K Brahmachari, Anshu Bhardwaj (2012) <i>PLoS One</i> <i></i> <i></i> 7: 7 <br/>

http://publicationslist.org/debasis.dash/refid37 2013-05-01T07:08:11Z

Despite vast amount of money and research being channeled toward biomedical research, relatively little impact has been made on routine clinical practice. At the heart of this failure is the information and communication technology "chasm" that exists between research and healthcare. A new focus on "knowledge engineering for health" is needed to facilitate knowledge transmission across the researc...<br/><br/>Tim Beck, Sirisha Gollapudi, Søren Brunak, Norbert Graf, Heinz U Lemke, Debasis Dash, Iain Buchan, Carlos Díaz, Ferran Sanz, Anthony J Brookes (2012) <i>Hum Mutat</i> <i></i> <i></i> 33: 5 797-802<br/>

http://publicationslist.org/debasis.dash/refid28 2011-07-30T14:56:16Z

Identification and study of genetic variation in recently admixed populations not only provides insight into historical population events but also is a powerful approach for mapping disease loci. We studied a population (OG-W-IP) that is of African-Indian origin and has resided in the western part of India for 500 years; members of this population are believed to be descendants of the Bantu-speaki...<br/><br/>Ankita Narang, Pankaj Jha, Vimal Rawat, Arijit Mukhopadhayay, Debasis Dash, Analabha Basu, Mitali Mukerji (2011) <i>Am J Hum Genet</i> <i></i> <i></i> 89: 1 111-120<br/>

http://publicationslist.org/debasis.dash/refid27 2011-07-30T14:56:16Z

ABSTRACT: BACKGROUND: The emergence of drug resistant tuberculosis poses a serious concern globally and researchers are in rigorous search for new drugs to fight against these dreadful bacteria. Recently, the bacterial GlmU protein, involved in peptidoglycan, lipopolysaccharide and techoic acid synthesis, has been identified as an important drug target. A unique C-terminal disordered tail, essenti...<br/><br/>Deepak Singla, Meenakshi Anurag, Debasis Dash, Gajendra P S Raghava (2011) <i>BMC Pharmacol</i> <i></i> <i></i> 11: 1 <br/>

http://publicationslist.org/debasis.dash/refid29 2011-07-30T14:56:16Z

Copy number variations (CNVs) have provided a dynamic aspect to the apparently static human genome. We have analyzed CNVs larger than 100 kb in 477 healthy individuals from 26 diverse Indian populations of different linguistic, ethnic and geographic backgrounds. These CNVRs were identified using the Affymetrix 50K Xba 240 Array. We observed 1,425 and 1,337 CNVRs in the deletion and amplification ...<br/><br/>Pramod Gautam, Pankaj Jha, Dhirendra Kumar, Shivani Tyagi, Binuja Varma, Debasis Dash, Arijit Mukhopadhyay, Mitali Mukerji (2011) <i>Hum Genet</i> <i></i> <i></i> : <br/>

http://publicationslist.org/debasis.dash/refid26 2011-07-30T14:56:16Z

Mass spectrometry has made rapid advances in the recent past and has become the preferred method for proteomics. Although many open source algorithms for peptide identification exist, such as X!Tandem and OMSSA, it has majorly been a domain of proprietary software. There is a need for better, freely available, and configurable algorithms that can help in identifying the correct peptides while keep...<br/><br/>Amit Kumar Yadav, Dhirendra Kumar, Debasis Dash (2011) <i>J Proteome Res</i> <i></i> <i></i> 10: 5 2154-2160<br/>

http://publicationslist.org/debasis.dash/refid30 2011-07-30T14:56:16Z

It is being realized that the traditional closed-door and market driven approaches for drug discovery may not be the best suited model for the diseases of the developing world such as tuberculosis and malaria, because most patients suffering from these diseases have poor paying capacity. To ensure that new drugs are created for patients suffering from these diseases, it is necessary to formulate a...<br/><br/>Anshu Bhardwaj, Vinod Scaria, Gajendra Pal Singh Raghava, Andrew Michael Lynn, Nagasuma Chandra, Sulagna Banerjee, Muthukurussi V Raghunandanan, Vikas Pandey, Bhupesh Taneja, Jyoti Yadav, Debasis Dash, Jaijit Bhattacharya, Amit Misra, Anil Kumar, Srinivasan Ramachandran, Zakir Thomas, Samir K Brahmachari (2011) <i>Tuberculosis (Edinb)</i> <i></i> <i></i> : <br/>

http://publicationslist.org/debasis.dash/refid33 2011-11-11T05:23:43Z

The genome sequencing of H37Rv strain of Mycobacterium tuberculosis was completed in 1998 followed by the whole genome sequencing of a clinical isolate, CDC1551 in 2002. Since then, the genomic sequences of a number of other strains have become available making it one of the better studied pathogenic bacterial species at the genomic level. However, annotation of its genome remains challenging beca...<br/><br/>Dhanashree S Kelkar, Dhirendra Kumar, Praveen Kumar, Lavanya Balakrishnan, Babylakshmi Muthusamy, Amit Kumar Yadav, Priyanka Shrivastava, Arivusudar Marimuthu, Sridhar Anand, Hema Sundaram, Reena Kingsbury, H C Harsha, Bipin Nair, T S Keshava Prasad, Devendra Singh Chauhan, Kiran Katoch, Vishwa Mohan Katoch, Prahlad Kumar, Raghothama Chaerkady, Srinivasan Ramachandran, Debasis Dash, Akhilesh Pandey (2011) <i>Mol Cell Proteomics</i> <i></i> <i></i> : <br/>

http://publicationslist.org/debasis.dash/refid31 2011-09-23T17:24:55Z

Plasma is the most easily accessible source for biomarker discovery in clinical proteomics. However, identifying potential biomarkers from plasma is a challenge given the large dynamic range of proteins. The potential biomarkers in plasma are generally present at very low abundance levels and hence identification of these low abundance proteins necessitates the depletion of highly abundant protein...<br/><br/>Amit Kumar Yadav, Gourav Bhardwaj, Trayambak Basak, Dhirendra Kumar, Shadab Ahmad, Ruby Priyadarshini, Ashish Kumar Singh, Debasis Dash, Shantanu Sengupta (2011) <i>PLoS One</i> <i></i> <i></i> 6: 9 <br/>

http://publicationslist.org/debasis.dash/refid24 2010-11-08T22:26:40Z

The Indian Genome Variation Consortium (IGVC) project, an initiative of the Council for Scientific and Industrial Research, has been the first large-scale comprehensive study of the Indian population. One of the major aims of the project is to study and catalog the variations in nearly thousand candidate genes related to diseases and drug response for predictive marker discovery, founder identific...<br/><br/>Ankita Narang, Rishi Das Roy, Amit Chaurasia, Arijit Mukhopadhyay, Mitali Mukerji, Debasis Dash (2010) <i>Database (Oxford)</i> <i></i> <i></i> 2010: <br/>

http://publicationslist.org/debasis.dash/refid23 2010-11-08T22:28:59Z

Torrents of genotype-phenotype data are being generated, all of which must be captured, processed, integrated, and exploited. To do this optimally requires the use of standard and interoperable "object models," providing a description of how to partition the total spectrum of information being dealt with into elemental "objects" (such as "alleles," "genotypes," "phenotype values," "methods") with ...<br/><br/>Anthony J Brookes, Heikki Lehvaslaiho, Juha Muilu, Yasumasa Shigemoto, Takashige Oroguchi, Takeshi Tomiki, Atsuhiro Mukaiyama, Akihiko Konagaya, Toshio Kojima, Ituro Inoue, Masako Kuroda, Hiroshi Mizushima, Gudmundur A Thorisson, Debasis Dash, Haseena Rajeevan, Matthew W Darlison, Mark Woon, David Fredman, Albert V Smith, Martin Senger, Kimitoshi Naito, Hideaki Sugawara (2009) <i>Hum Mutat</i> <i></i> <i></i> 30: 6 968-977<br/>

http://publicationslist.org/debasis.dash/refid25 2010-11-08T22:27:35Z

Many eukaryotic and prokaryotic proteins remain disordered under physiological conditions and often acquire a stable secondary structure on binding to their cellular targets. Though the process of binding is still under analysis, it has been found that the flexibility of proteins can add to their functionality. This motivated us to explore intrinsically disordered proteins (IDPs) as drug targets. ...<br/><br/>Meenakshi Anurag, Debasis Dash (2009) <i>Mol Biosyst</i> <i></i> <i></i> 5: 12 1752-1757<br/>

http://publicationslist.org/debasis.dash/refid1 2010-11-08T22:28:09Z

The Human Genome Variation database of Genotype to Phenotype information (HGVbaseG2P) is a new central database for summary-level findings produced by human genetic association studies, both large and small. Such a database is needed so that researchers have an easy way to access all the available association study data relevant to their genes, genome regions or diseases of interest. Such a deposi...<br/><br/>Gudmundur A Thorisson, Owen Lancaster, Robert C Free, Robert K Hastings, Pallavi Sarmah, Debasis Dash, Samir K Brahmachari, Anthony J Brookes (2009) <i>Nucleic Acids Res</i> <i></i> <i></i> 37: Database issue D797-D802<br/>

http://publicationslist.org/debasis.dash/refid2 2008-10-28T06:28:15Z

Intrinsically disordered proteins are very common in eukaryotes and thus understanding functional roles and factors which influence protein disorderness becomes very important. In this work, we ask whether global properties not directly related to the function of the proteins, like expression level and avoidance of aggregation, influence disorderness of proteins. We found that proteins expressed a...<br/><br/>Gajinder Pal Singh, Debasis Dash (2008) <i>Biochem Biophys Res Commun</i> <i></i> <i></i> 371: 3 401-404<br/>

http://publicationslist.org/debasis.dash/refid21 2008-10-28T06:39:42Z

Analyses of frequency profiles of markers on disease or drug-response related genes in diverse populations are important for the dissection of common diseases. We report the results of analyses of data on 405 SNPs from 75 such genes and a 5.2 Mb chromosome, 22 genomic region in 1871 individuals from diverse 55 endogamous Indian populations. These include 32 large (>10 million individuals) and 23 i...<br/><br/> (2008) <i>J Genet</i> 87: 1 3-20<br/>

http://publicationslist.org/debasis.dash/refid5 2008-10-28T06:28:15Z

Hubs in the protein-protein interaction network have been classified as "party" hubs, which are highly correlated in their mRNA expression with their partners while "date" hubs show lesser correlation. In this study, we explored the role of intrinsic disorder in date and party hub interactions. The data reveals that intrinsic disorder is significantly enriched in date hub proteins when compared wi...<br/><br/>Gajinder Pal Singh, Mythily Ganapathi, Debasis Dash (2007) <i>Proteins</i> <i></i> <i></i> 66: 4 761-765<br/>

http://publicationslist.org/debasis.dash/refid3 2008-10-28T06:28:15Z

Intrinsic disorder has been shown to be important in mediating protein-protein and protein-DNA interactions. Proteins involved in regulatory functions are particularly enriched in intrinsic disorder. In this study we explored the role of intrinsic disorder in transcriptional regulatory network of yeast. Using disorder prediction programs we show that transcription factors (TFs) regulating large nu...<br/><br/>Gajinder Pal Singh, Debasis Dash (2007) <i>Proteins</i> <i></i> <i></i> 68: 3 602-605<br/>

http://publicationslist.org/debasis.dash/refid22 2008-10-28T06:56:58Z

M. Vidyasagar, S, Mande, S. Rajgopal, B. Gopalkrishnan, S. T. P. T. Srinivas, C. Uma,Maheswara Rao, T. Kathiravan, K. Mastanarao, S. Narendranath, S.Rohini, A. Irshad, T. Murali, C. Subrahmanyam, T. Mona, S. Sankha, V. Priya, D. Suman, V. V. Raja Rao, P. Nageswara Rao, R. Issaac, H. Yashodeep, B. Arundhoti, G. Nishant, S Jignesh, K. S. Chaitanya, S. P.V. Prasad Reddy; P. Chakraborty; S. E. Hasnain, S. Mande, A. Nagarajaram, A. Ranjan, M. S. Acharya, M. Anwaruddin, S. K. Arun, Gyanrajkumar,D. Kumar, S. Priya, S. Ranjan, B. R. Reddi, J. Seshadri, P. SravanKumar, S. Swaminathan, P. Umadevi, V. Vindal, S. Vijaykrishnan; A. K. Saxena, A. Dixit, P. Prathipati,S. K. Kashaw; C. Mandal, S.Bag; N. Balakrishnan, M. Bansal, N. R.Chandra, M. R. N. Murthy, S. Ramakumar, K. Sekar, N. Srinivasan,K. Suguna, S. Vishveshwara, R. Anandhi, Bhadra, S. Das, P. Hansia,S. Hariharaputran, J. Jeyakani, R. Karthikeyan, R. K. Pandey, C. S.Swamy, B. Vasanthakumar, P. V. Balaji, R. Y. Patel, B. Jayaram, S. A. Shaikh,P. P. Chakrabarti, A. Banerjee, A. Chakrabarti,R. L. Karandikar, P. Chaudhuri, G. P. S. Raghava, A. Ghosh, M. Bansal, N. Paramsivam, S. K. Brahmachari, D.Dash, C. Balasubramaniam, A. Basu, P. Biswas, M. Hariharan, R.Mathur, K. S. Sandhu, V. Scaria, R. Shankar, P. J. Narayanan, V. Jain, Nirnimesh, S. Krishnaswamy, V. Alaguraj, R. Marikkannu, A. V. S. K. Mohan Katta, N. Krishnan, K. V. Srividhya, P. J. Eswari, P. V. Bharatam, P. Iqbal, D. Bhattacharyya, G. R. Desiraju, J. J. Kumar, M. Ravikumar; M. Gautham, P. A. Prasad, D. Bharanidharan (2007) <i>Current science</i> Vol. 92: NO. 1, 29 - 38<br/>

http://publicationslist.org/debasis.dash/refid4 2008-10-28T06:28:15Z

Structural transitions are important for the stability and function of proteins, but these phenomena are poorly understood. An extensive analysis of Protein Data Bank entries reveals 103 regions in proteins with a tendency to transform from helical to nonhelical conformation and vice versa. We find that these dynamic helices, unlike other helices, are depleted in hydrophobic residues. Furthermore,...<br/><br/>Kuljeet Singh Sandhu, Debasis Dash (2007) <i>Proteins</i> <i></i> <i></i> 68: 1 109-122<br/>

http://publicationslist.org/debasis.dash/refid7 2008-10-28T06:28:15Z

The study of unfolded protein regions has gained importance because of their prevalence and important roles in various cellular functions. These regions have characteristically high net charge and low hydrophobicity. The amino acid sequence determines the intrinsic unstructuredness of a region and, therefore, efforts are ongoing to delineate the sequence motifs, which might contribute to protein d...<br/><br/>Gajinder Pal Singh, Mythily Ganapathi, Kuljeet Singh Sandhu, Debasis Dash (2006) <i>Proteins</i> <i></i> <i></i> 62: 2 309-315<br/>

http://publicationslist.org/debasis.dash/refid6 2008-10-28T06:28:15Z

PEST sequences are one of the major motifs that serve as signal for the protein degradation and are also involved in various cellular processes such as phosphorylation and protein-protein interaction. In our earlier study, we found that these motifs contribute largely to eukaryotic protein disorder. This observation led us to evaluate their conformational variability in the nonredundant Protein Da...<br/><br/>Kuljeet Singh Sandhu, Debasis Dash (2006) <i>Proteins</i> <i></i> <i></i> 63: 4 727-732<br/>

http://publicationslist.org/debasis.dash/refid8 2008-10-28T06:28:15Z

The functional significance of evolutionarily conserved motifs/patterns of short regions in proteins is well documented. Although a large number of sequences are conserved, only a small fraction of these are invariant across several organisms. Here, we have examined the structural features of the functionally important peptide sequences, which have been found invariant across diverse bacterial gen...<br/><br/>Tulika Prakash, C Ramakrishnan, Debasis Dash, Samir K Brahmachari (2005) <i>J Mol Biol</i> <i></i> <i></i> 345: 5 937-955<br/>

http://publicationslist.org/debasis.dash/refid20 2008-10-28T06:36:36Z

Indian population, comprising of more than a billion people, consists of 4693 communities with several thousands of endogamous groups, 325 functioning languages and 25 scripts. To address the questions related to ethnic diversity, migrations, founder populations, predisposition to complex disorders or pharmacogenomics, one needs to understand the diversity and relatedness at the genetic level in s...<br/><br/> (2005) <i>Hum Genet</i> 118: 1 1-11<br/>

http://publicationslist.org/debasis.dash/refid9 2008-10-28T06:28:15Z

Absence of any regular structure is increasingly being observed in structural studies of proteins. These disordered regions or random coils, which have been observed under physiological conditions, are indicators of protein plasticity. The wide variety of interactions possible due to the flexibility of these 'natively disordered' regions confers functional advantage to the protein and the organism...<br/><br/>Neeraj Pandey, Mythily Ganapathi, Kaushal Kumar, Dipayan Dasgupta, Sushanta Kumar Das Sutar, Debasis Dash (2004) <i>Bioinformatics</i> <i></i> <i></i> 20: 17 2904-2910<br/>

http://publicationslist.org/debasis.dash/refid10 2008-10-28T06:28:15Z

Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The yeast Ino80, the catalytic ATPase subunit of the INO80 complex, is the most recently described member of the SNF2 family. Outside the conserved ATPase domain, it has very little similarity with other well-characteri...<br/><br/>Rachit Bakshi, Tulika Prakash, Debasis Dash, Vani Brahmachari (2004) <i>Biochem Biophys Res Commun</i> <i></i> <i></i> 320: 1 197-204<br/>

http://publicationslist.org/debasis.dash/refid12 2008-10-28T06:28:15Z

MOTIVATION: The recent outbreak of severe acute respiratory syndrome (SARS) caused by SARS coronavirus (SARS-CoV) has necessitated an in-depth molecular understanding of the virus to identify new drug targets. The availability of complete genome sequence of several strains of SARS virus provides the possibility of identification of protein-coding genes and defining their functions. Computational a...<br/><br/>Ramakant Sharma, Jitendra Kumar Maheshwari, Tulika Prakash, Debasis Dash, Samir K Brahmachari (2004) <i>Bioinformatics</i> <i></i> <i></i> 20: 7 1074-1080<br/>

http://publicationslist.org/debasis.dash/refid11 2008-10-28T06:28:15Z

We present the development of a Comprehensive database of 12 076 invariant Peptide Signatures (CoPS) derived from 52 bacterial genomes with a minimum occurrence in at least seven organisms. These peptides were observed in functionally similar proteins and are distributed over nearly 1250 different functional proteins. The database provides function, structure and occurrence in biochemical pathways...<br/><br/>Tulika Prakash, Mamta Khandelwal, Dipayan Dasgupta, Debasis Dash, Samir K Brahmachari (2004) <i>Bioinformatics</i> <i></i> <i></i> 20: 16 2886-2888<br/>

http://publicationslist.org/debasis.dash/refid13 2008-10-28T06:28:15Z

Polyglutamine expansions, leading to aggregation, have been implicated in various neurodegenerative disorders. The range of repeats observed in normal individuals in most of these diseases is 19-36, whereas mutant proteins carry 40-81 repeats. In one such disorder, spinocerebellar ataxia (SCA1), it has been reported that certain individuals with expanded polyglutamine repeats in the disease range ...<br/><br/>Somdutta Sen, Debasis Dash, Santosh Pasha, Samir K Brahmachari (2003) <i>Protein Sci</i> <i></i> <i></i> 12: 5 953-962<br/>

http://publicationslist.org/debasis.dash/refid14 2008-10-28T06:28:15Z

Analysis of sequence complexities of proteins is an important step in the characterization and classification of new genomes. A new measure has been proposed to compute sequence complexity in protein sequences based on linguistic complexity. The algorithm requires a single parameter, is computationally simple and provides a framework for comparative genomic analysis. Protein sequences were classif...<br/><br/>Tannistha Nandi, Debasis Dash, Rohit Ghai, Chandrika B-Rao, K Kannan, Samir K Brahmachari, C Ramakrishnan, Srinivasan Ramachandran (2003) <i>J Biomol Struct Dyn</i> <i></i> <i></i> 20: 5 657-668<br/>

http://publicationslist.org/debasis.dash/refid16 2008-10-28T06:28:15Z

In this report, the spectrum of beta-thalassemia mutations and genotype-to-phenotype correlations were defined in large number of patients (beta-thalassemia carriers and major) with varying disease severity in an Eastern Indian population mainly from the state of West Bengal. The five most common beta-thalassemia mutations were detected, which included IVS1-5 (G-->C), codon 15 (G-->A), codon 26 (G...<br/><br/>Ritushree Kukreti, Debasis Dash, Vineetha K E, Sanchita Chakravarty, Swapan Kr Das, Madhusnata De, Geeta Talukder (2002) <i>Am J Hematol</i> <i></i> <i></i> 70: 4 269-277<br/>

http://publicationslist.org/debasis.dash/refid15 2008-10-28T06:28:15Z

Expansion of GAA repeats in the intron of the frataxin gene is involved in the autosomal recessive Friedreich's ataxia (FRDA). The GAA repeats arise from a stretch of adenine residues of an Alu element. These repeats have a size ranging from 7- 38 in the normal population, and expand to thousands in the affected individuals. The mechanism of origin of GAA repeats, their polymorphism and stability ...<br/><br/>Chitra Chauhan, Debasis Dash, Deepak Grover, Jaya Rajamani, Mitali Mukerji (2002) <i>J Biomol Struct Dyn</i> <i></i> <i></i> 20: 2 253-263<br/>

http://publicationslist.org/debasis.dash/refid19 2009-07-08T08:49:27Z

Chromosome 22 has been implicated in schizophrenia and bipolar disorder in a number of linkage, association and cytogenetic studies. Recent evidence has also implicated CAG repeat tract expansion in these diseases. In order to explore the involvement of CAG repeats on chromosome 22 in these diseases, we have created an integrated map of all CAG repeats > or =5 on this chromosome together with micr...<br/><br/>Q Saleem, D Dash, C Gandhi, A Kishore, V Benegal, T Sherrin, O Mukherjee, S Jain, S K Brahmachari (2001) <i>Mol Psychiatry</i> 6: 6 694-700<br/>

http://publicationslist.org/debasis.dash/refid17 2008-10-28T06:28:15Z

The most common mutation associated with Progressive Myoclonus Epilepsy (EPM1) of Unverricht-Lundberg type is the expansion of a dodecamer repeat, d(CCCCGCCCCGCG)n. We show that the C-rich strand of this repeat (2-3 copies) forms intercalated i-motif structure at acidic pH as judged by CD spectroscopy and anomalous gel electrophoretic mobility. The stability of the structure increases with the inc...<br/><br/>S S Pataskar, D Dash, S K Brahmachari (2001) <i>J Biomol Struct Dyn</i> <i></i> <i></i> 19: 2 307-313<br/>

http://publicationslist.org/debasis.dash/refid18 2008-10-28T06:28:15Z

The secondary structure of DNA has been shown to be an important component in the mechanism of expansion of the trinucleotide repeats that are associated with many neurodegenerative disorders. Recently, expansion of a dodecamer repeat, (CCCCGCCCCGCG)n upstream of cystatin B gene has been shown to be the most common mutation associated with Progressive Myoclonus Epilepsy (EPM1) of Unverricht-Lundbo...<br/><br/>S S Pataskar, D Dash, S K Brahmachari (2001) <i>J Biomol Struct Dyn</i> <i></i> <i></i> 19: 2 293-305<br/>

http://publicationslist.org/debasis.dash/refid38 2013-05-01T10:45:22Z

() <i></i> : <br/>