http://publicationslist.org/data/devashish.das/atom.xml D Dashttp://publicationslist.org/devashish.das$basepathfavicon.icoRecent additions to D Das's PublicationsList.org pagehttp://publicationslist.org/publications.png2017-07-31T11:43:36Z http://publicationslist.org/devashish.das/refid20 2017-07-31T11:43:32Z

Leigh Disease is a progressive neurometabolic disorder for which a clinical effective treatment is currently still lacking. Here, we report on the therapeutic efficacy of KH176, a new chemical entity derivative of Trolox, in Ndufs4-/- mice, a mammalian model for Leigh Disease. Using in vivo brain diffusion tensor imaging, we show a loss of brain microstructural coherence in Ndufs4-/- mice in the c...<br/><br/>Ria Haas, Devashish Das, Alejandro Garanto, G. Herma Renkema, Rick Greupink, Petra van den Broek, Jeanne C Pertijs, Rob Collin, Peter Willems, Julien Beyrath, Arend Heerschap, Frans Russel, and Jan Smeitink (2017) <i>Scientific Reports</i> : <br/>

http://publicationslist.org/devashish.das/refid18 2017-02-17T12:29:36Z

Permissive hypercapnia is commonly used as vasodilatory challenge in clinical applications and basic research. During fMRI experiments, continuous exposure to mild (3-10%) CO2 can be applied to derive stimulus induced changes in the cerebral rate of oxygen consumption (CMRO2) by measuring cerebral blood flow and the blood oxygenation dependent (BOLD) signal. Previous data from anesthetized primate...<br/><br/>Devashish Das, Aneurin J Kennerley, Samuel Harris, Jason Berwick (2017) <i>Proc. Intl. Soc. Mag. Reson. Med. (2017).</i> <br/>

http://publicationslist.org/devashish.das/refid19 2017-02-17T12:32:39Z

This study uses multi-parametric MRI measures to further our understanding on the pathophysiology of migraine in a novel preclinical model of medication overuse headache. Rats undergo sustained triptan exposure inducing cutaneous allodynia. Following drug exposure, we perform ASL, NMR, connectivity and evoked response BOLD fMRI to investigate sustained neuronal adaptations/changes. We investigate ...<br/><br/>Aneurin James Kennerley, Devashish Das, Fiona Boissonade, Milena De-Felice (2017) <i>Proc. Intl. Soc. Mag. Reson. Med (2017)</i> <br/>

http://publicationslist.org/devashish.das/refid14 2016-02-10T14:11:11Z

In vivo assignment of lactate remains ambiguous. However, unambiguous visualization is necessary for understanding mechanisms associated with skeletal muscle ischemia in rodents, and for the assessment of treatment in the dysfunctional muscle of transgenic animals. In this study we address unambiguous detection of lactate methylene and methyl groups in the ischemic hindleg of mice, subjected to pr...<br/><br/>Devashish Das, Andor Veltien, and Arend Heerschap (2016) <i>ISMRM 2016</i> <br/>

http://publicationslist.org/devashish.das/refid15 2016-06-19T17:52:46Z

Abstract: In vivo assignment of lactate remains ambiguous. However, unambiguous visualization is necessary for understanding mechanisms associated with skeletal muscle ischemia in rodents, and for the assessment of treatment in the dysfunctional muscle of transgenic animals. In this study we address unambiguous detection of lactate methylene and methyl groups in the ischemic hindleg of mice, subje...<br/><br/>Devashish Das, Andor Veltien, Arend Heerschap (2016) <i>Proc. Intl. Soc. Mag. Reson. Med. 24 (2016)</i> 24: 4020<br/>

http://publicationslist.org/devashish.das/refid17 2017-01-10T21:56:20Z

At ultra-high field (11.7T) unambiguous detection of lactate resonances in the ischemic and/or hypoxic rodent muscle remains challenging, however, necessary for the assessment of treatment in the dysfunctional muscle of transgenic animals. In this study we address unambiguous detection of lactate methine and methyl groups in the ischemic hindleg of mice, subjected to prolong ischemia (~35min). U...<br/><br/>D Das, A Veltien, A.J Kennerley, A Heerschap (2016) <i>ISMRM British Chapter</i> <br/>

http://publicationslist.org/devashish.das/refid16 2017-02-16T10:15:50Z

The nucleotide excision repair protein complex ERCC1-XPF is required for incision of DNA upstream of the DNA damage. Functional studies have provided insight into the binding of ERCC1-XPF to various DNA substrates. However, since no structure for the ERCC1-XPF-DNA complex has been determined, the mechanism of substrate recognition remains elusive. Here we biochemically characterize the substrate p...<br/><br/>Devashish Das, Maryam Faridounnia, Lidija Kovacic, Robert Kaptein, Rolf Boelens and Gert E. Folkers (2016) <i></i> : <br/>

http://publicationslist.org/devashish.das/refid13 2017-01-10T22:16:12Z

Complex 1 mutations are the most common cause of mitochondrial diseases involving progressive encephalopathy (1–4). A hallmark imaging feature is the presence of white matter lesions (WMLs) in specific brain areas, such as the thalamus, on T2 MRI. As the assessment of new treatments in this relatively rare disease is problematic the use of animal models is desired. A mouse model with a com...<br/><br/>D. Das, R. Haas, A.Veltien,J. Smeitink, A.Heerschap (2015) <i>Magnetic Resonance Materials in Physics, Biology and Medicine</i> 28: 1 110-111<br/>

http://publicationslist.org/devashish.das/refid12 2016-06-19T17:45:37Z

X-linked creatine metabolism defect is a result of mutations in Slc6a8 gene (1). This gene encodes a transmembrane creatine transporter protein (CrT), which is highly expressed in brain and skeletal muscle cells with fluctuating energy demands. In male carriers creatine transporter deficiency severely affects brain structure and function. These patients experience growth and developmental dela...<br/><br/> Devashish Das, Chi-Un Choe, Malte Stockebrand, Andor Veltien, Houshang AmiriDoumari, Dirk Isbrandt, Arend Heerschap (2014) <i>Proc. Intl. Soc. Mag. Reson. Med. 22 (2014)</i> <i>ISMRM</i> 22: 3496 <br/>

http://publicationslist.org/devashish.das/refid11 2014-04-25T11:25:37Z

D Das, A Veltien, C.U Choe, M Stockebrand, D Isbrandt, A Heerschap (2013) <i>MAGMA</i> 26: 1 361<br/>

http://publicationslist.org/devashish.das/refid8 2012-04-04T13:08:12Z

Human XPF/ERCC1 is a structure specific DNA endonuclease that nicks the damaged DNA strand at the 5’ end during nucleotide excision repair. We determined the structure of the complex of C-terminal domain of XPF with 10 nt ssDNA. A positively charged region within the second helix of the first HhH motif contacts the ssDNA phosphate backbone. One guanine base is flipped out of register...<br/><br/>Devashish Das, Gert E .Folkers, Marc van Dijk, Nicolaas G.J. Jaspers, Jan H.J Hoeijmakers, Robert Kaptein, Rolf Boelens (2012) <i>Structure</i> 20: 4 667-675<br/>

http://publicationslist.org/devashish.das/refid7 2012-04-06T08:26:40Z

The human ubiquitin-conjugating enzyme Rad6 (E2), with ubiquitin ligase enzyme Rad18 (RING E3), monoubiquitinates proliferating cell nuclear antigen at stalled replication forks in DNA translesion synthesis. Here, we determine the structure of the homodimeric Rad18 RING domains by X-ray crystallography and classify it to RING-RING dimers that dimerize through helices adjacent to the RING domains a...<br/><br/>Anding Huang, Richard G Hibbert, Rob N de Jong, Devashish Das, Titia K Sixma, Rolf Boelens (2011) <i>J Mol Biol</i> <i></i> <i></i> 410: 3 424-435<br/>

http://publicationslist.org/devashish.das/refid10 2013-01-21T13:48:57Z

Fibulin-4 is a glycoprotein, expressed in medial layers of arteries, heart valves and the myocardium. Mice homozygous for the fibulin-4 reduced expression allele (Fibulin-4R/R) show severe dilation of the ascending aorta resulting from disorganized elastic fibers and excessive TGFβ signaling. Strikingly, even a modest reduction in the Fibulin-4+/R mice results in mild abnormalities. We used these...<br/><br/>Els Moltzer, Devashish Das, Paula M van Heijningen, Dick H Dekkers, Marcel Vermeij, Miranda Harteveld, Wim Sluiter, Richard van Veghel, Lambert Speelman, Ivo Que, Eric Kaijzel, Clemens Lowik, A. H. Jan Danser, Jeroen A Demmers, Roland Kanaar, Jeroen Essers (2011) <i>Circulation</i> 124: 21 A15331<br/>

http://publicationslist.org/devashish.das/refid6 2011-05-25T22:34:49Z

Fibulin-4 is a secreted glycoprotein, which is expressed in medial layers of blood vessels. All six reported fibulin-4 patients suffer from cardiovascular complications including aortic aneurysms, arterial tortuosity and stenosis and elastin abnormalities. We have engineered fibulin-4 mouse models that express reduced levels of the fibulin-4 protein and develop aortic abnormalities similar to fibu...<br/><br/>Devashish Das; Paula M van Heijningen; Dick H Dekkers; Marcel Vermeij; Wim Sluiter; Roland Kanaar; Jeroen Demmers; Jeroen Essers (2010) <i>Circulation</i> <i></i> 122: A15787 <br/>

http://publicationslist.org/devashish.das/refid1 2008-11-07T15:49:50Z

The human XPF-ERCC1 protein complex plays an essential role in nucleotide excision repair by catalysing positioned nicking of a DNA strand at the 5' side of the damage. We have recently solved the structure of the heterodimeric complex of the C-terminal domains of XPF and ERCC1 (Tripsianes et al., Structure 2005;13:1849-1858). We found that this complex comprises a pseudo twofold symmetry axis and...<br/><br/>Devashish Das, Konstantinos Tripsianes, Nicolaas G J Jaspers, Jan H J Hoeijmakers, Robert Kaptein, Rolf Boelens, Gert E Folkers (2008) <i>Proteins</i> <i></i> <i></i> 70: 4 1551-1563<br/>

http://publicationslist.org/devashish.das/refid2 2008-11-07T15:49:50Z

Human ERCC1/XPF is a structure-specific endonuclease involved in multiple DNA repair pathways. We present the solution structure of the non-catalytic ERCC1 central domain. Although this domain shows structural homology with the catalytically active XPF nuclease domain, functional investigation reveals a completely distinct function for the ERCC1 central domain by performing interactions with both ...<br/><br/>Konstantinos Tripsianes, Gert E Folkers, Chao Zheng, Devashish Das, Jeffrey S Grinstead, Robert Kaptein, Rolf Boelens (2007) <i>Nucleic Acids Res</i> <i></i> <i></i> 35: 17 5789-5798<br/>

http://publicationslist.org/devashish.das/refid3 2008-11-07T15:49:50Z

The human ERCC1/XPF complex is a structure-specific endonuclease with defined polarity that participates in multiple DNA repair pathways. We report the heterodimeric structure of the C-terminal domains of both proteins responsible for ERCC1/XPF complex formation. Both domains exhibit the double helix-hairpin-helix motif (HhH)2, and they are related by a pseudo-2-fold symmetry axis. In the XPF doma...<br/><br/>Konstantinos Tripsianes, Gert Folkers, Eiso Ab, Devashish Das, Hanny Odijk, Nicolaas G J Jaspers, Jan H J Hoeijmakers, Robert Kaptein, Rolf Boelens (2005) <i>Structure</i> <i></i> <i></i> 13: 12 1849-1858<br/>

http://publicationslist.org/devashish.das/refid4 2008-11-07T15:49:50Z

Recognition of the lac operator by the lac repressor involves specific interactions between residues in the repressor's recognition helix and bases in the DNA major groove. Tyr17 and Gln18, at positions 1 and 2 in the lac repressor recognition helix, can be exchanged for other amino acids to generate mutant repressors that display altered specificity. We have solved the solution structure of a pro...<br/><br/>Roberto Kopke Salinas, Gert E Folkers, Alexandre M J J Bonvin, Devashish Das, Rolf Boelens, Robert Kaptein (2005) <i>Chembiochem</i> <i></i> <i></i> 6: 9 1628-1637<br/>