http://publicationslist.org/data/dhanas.muthu/atom.xml Dhanasekaran Muthuhttp://publicationslist.org/dhanas.muthu$basepathfavicon.icoRecent additions to Dhanasekaran Muthu's PublicationsList.org pagehttp://publicationslist.org/publications.png2008-06-17T22:37:27Z http://publicationslist.org/dhanas.muthu/refid1 2008-06-17T22:34:10Z

The GAGA factor of Drosophila melanogaster uses a single Cys2-His2-type zinc finger for specific DNA binding. Comparative sequence alignment of the GAGA zinc finger core with other structurally characterized zinc fingers reveals that the beta-hairpin of the GAGA zinc finger prefers amino acids with an aliphatic side-chain different from those of other zinc fingers. To probe the substitution effect...<br/><br/>Muthu Dhanasekaran, Shigeru Negi, Miki Imanishi, Yukio Sugiura (2007) <i>Biochemistry</i> <i></i> <i></i> 46: 25 7506-7513<br/>

http://publicationslist.org/dhanas.muthu/refid3 2008-06-17T22:34:10Z

The design of artificial functional DNA-binding proteins has long been a goal for several research laboratories. The zinc finger proteins, which typically contain many fingers linked in tandem fashion, are some of the most studied DNA-binding proteins. The zinc finger protein's tandem arrangement and its the ability to recognize a wide variety of DNA sequences make it an attractive framework to de...<br/><br/>Muthu Dhanasekaran, Shigeru Negi, Yukio Sugiura (2006) <i>Acc Chem Res</i> <i></i> <i></i> 39: 1 45-52<br/>

http://publicationslist.org/dhanas.muthu/refid2 2008-06-17T22:34:10Z

To experimentally demonstrate the mirror-image recognition in protein and DNA interaction, we have designed a small DNA-binding peptide based on the zinc-finger domain of GAGA transcription factor. Circular dichroism data suggest that the conformations of peptide enantiomers as well as the DNA enantiomers have a mirror-image relationship. The gel mobility shift assay showed that the synthetic enan...<br/><br/>Shigeru Negi, Muthu Dhanasekaran, Tsuyoshi Hirata, Hidehito Urata, Yukio Sugiura (2006) <i>Chirality</i> <i></i> <i></i> 18: 4 254-258<br/>

http://publicationslist.org/dhanas.muthu/refid4 2008-06-17T22:34:10Z

Antinociceptive effects and BBB transport properties of glycosylated enkephalin derivatives are reviewed. Previously, the application of enkephalins as analgesics has been retarded by their poor stability in vivo and by their inability to effectively penetrate the blood brain barrier. This shortcoming has been overcome by glycosylation, paradoxically leading to enhanced BBB transport via transcyto...<br/><br/>Muthu Dhanasekaran, Robin Polt (2005) <i>Curr Drug Deliv</i> <i></i> <i></i> 2: 1 59-73<br/>

http://publicationslist.org/dhanas.muthu/refid5 2008-06-17T22:34:10Z

The application of endogenous neuropeptides (e.g., enkephalins) as analgesics has been retarded by their poor stability in vivo and by their inability to effectively penetrate the blood-brain barrier (BBB). Effective BBB transport of glycosylated enkephalins has been demonstrated in several labs now. Analgesia (antinociception) levels greater than morphine, and with reduced side effects have been ...<br/><br/>Robin Polt, Muthu Dhanasekaran, Charles M Keyari (2005) <i>Med Res Rev</i> <i></i> <i></i> 25: 5 557-585<br/>

http://publicationslist.org/dhanas.muthu/refid6 2008-06-17T22:34:10Z

A series of glycosylated endorphin analogues designed to penetrate the blood-brain barrier (BBB) have been studied by circular dichroism and by 2D-NMR in the presence of water; TFE/water; SDS micelles; and in the presence of both neutral and anionic bicelles. In water, the glycopeptides showed only nascent helix behavior and random coil conformations. Chemical shift indices and nuclear Overhauser ...<br/><br/>Muthu Dhanasekaran, Michael M Palian, Isabel Alves, Larisa Yeomans, Charles M Keyari, Peg Davis, Edward J Bilsky, Richard D Egleton, Henry I Yamamura, Neil E Jacobsen, Gordon Tollin, Victor J Hruby, Frank Porreca, Robin Polt (2005) <i>J Am Chem Soc</i> <i></i> <i></i> 127: 15 5435-5448<br/>

http://publicationslist.org/dhanas.muthu/refid8 2008-06-17T22:34:10Z

Development of opioid peptides as therapeutic agents has historically been limited due to pharmacokinetic issues including stability and blood-brain barrier (BBB) permeability. Glycosylation of opioid peptides can increase peptide serum stability and BBB penetration. To further define the requirements for optimizing in vivo antinociceptive potency following intravenous administration, we synthesiz...<br/><br/>Nura O Elmagbari, Richard D Egleton, Michael M Palian, John J Lowery, Wendi R Schmid, Peg Davis, Edita Navratilova, Muthu Dhanasekaran, Charles M Keyari, Henry I Yamamura, Frank Porreca, Victor J Hruby, Robin Polt, Edward J Bilsky (2004) <i>J Pharmacol Exp Ther</i> <i></i> <i></i> 311: 1 290-297<br/>

http://publicationslist.org/dhanas.muthu/refid7 2008-06-17T22:34:10Z

A model beta-hairpin dodecapeptide [EFGWVpGKWTIK] was designed by including a favorable D-ProGly Type II' beta-turn sequence and a Trp-zip interaction, while also incorporating a beta-strand unfavorable glycine residue in the N-terminal strand. This peptide is highly folded and monomeric in aqueous solution as determined by combined analysis with circular dichroism and 1H NMR spectroscopy. A pepti...<br/><br/>Muthu Dhanasekaran, Om Prakash, Yu Xi Gong, Paul W Baures (2004) <i>Org Biomol Chem</i> <i></i> <i></i> 2: 14 2071-2082<br/>

http://publicationslist.org/dhanas.muthu/refid9 2008-06-17T22:34:10Z

The hepatitis C virus (HCV) is a causal agent of chronic liver infection, cirrhosis, and hepatocellular carcinoma infecting more than 170 million people. CD81 is a receptor for HCV envelope glycoprotein E2. Although the binding of HCV-E2 with CD81 is well documented the role of this interaction in the viral life cycle remains unclear. Host specificity and mutagenesis studies suggest that the helix...<br/><br/>Scott E VanCompernolle, Alexander V Wiznycia, Jeremy R Rush, Muthu Dhanasekaran, Paul W Baures, Scott C Todd (2003) <i>Virology</i> <i></i> <i></i> 314: 1 371-380<br/>

http://publicationslist.org/dhanas.muthu/refid10 2008-06-17T22:34:10Z

Fumaramide derivatives were analyzed in solution by (1)H NMR spectroscopy and in the solid state by X-ray crystallography in order to characterize the formation of CH...O interactions under each condition and to thereby serve as models for these interactions in peptide and protein structure. Solutions of fumaramides at 10 mM in CDCl(3) were titrated with DMSO-d(6), resulting in chemical shifts tha...<br/><br/>Paul W Baures, Alicia M Beatty, Muthu Dhanasekaran, Brian A Helfrich, Waleska Pérez-Segarra, John Desper (2002) <i>J Am Chem Soc</i> <i></i> <i></i> 124: 38 11315-11323<br/>