http://publicationslist.org/data/dimitar.sajkov/atom.xml Dimitar Sajkovhttp://publicationslist.org/dimitar.sajkov$basepathfavicon.icoRecent additions to Dimitar Sajkov's PublicationsList.org pagehttp://publicationslist.org/publications.png2007-08-30T00:56:34Z http://publicationslist.org/dimitar.sajkov/refid1 2007-08-30T00:45:13Z

Daytime pulmonary hypertension (PH) is relatively common in obstructive sleep apnea (OSA) and is thought to be associated with pulmonary vascular remodeling (PRm). The extent to which PH is reversible with treatment is uncertain. To study this, we measured pulmonary hemodynamics (Doppler echocardiography) in 20 patients with OSA (apnea-hypopnea index [AHI] 48.6 +/- 5.2/h, mean +/- SEM) before and ...<br/><br/>Dimitar Sajkov, Tingting Wang, Nicholas A Saunders, Alexandra J Bune, R Douglas Mcevoy (2002) <i>Am J Respir Crit Care Med</i> <i></i> <i></i> 165: 2 152-158<br/>

http://publicationslist.org/dimitar.sajkov/refid3 2007-08-30T00:45:13Z

STUDY OBJECTIVE: We compared the validity of a new portable polysomnographic recorder against a laboratory-based polysomnographic system from the same manufacturer. DESIGN AND PATIENTS: Simultaneous, full polysomnographic recordings from the portable device (PSGP) and the laboratory-based system (PSGL) were obtained using separate sets of sensors on 20 patients referred for investigation of sleep ...<br/><br/>I J Mykytyn, D Sajkov, A M Neill, R D McEvoy (1999) <i>Chest</i> <i></i> <i></i> 115: 1 114-122<br/>

http://publicationslist.org/dimitar.sajkov/refid2 2007-08-30T00:45:13Z

It is controversial whether obstructive sleep apnea (OSA) causes pulmonary hypertension (PH) in the absence of hypoxemic lung disease. To investigate this further we measured awake pulmonary hemodynamics, pulmonary gas exchange, and small airways function in 32 patients with OSA (apnea- hypopnea index, mean +/- SE, 46.2 +/- 3. 9/h) who had normal screening lung function. Pulmonary artery pressure ...<br/><br/>D Sajkov, T Wang, N A Saunders, A J Bune, A M Neill, R Douglas Mcevoy (1999) <i>Am J Respir Crit Care Med</i> <i></i> <i></i> 159: 5 Pt 1 1518-1526<br/>

http://publicationslist.org/dimitar.sajkov/refid4 2007-08-30T00:45:13Z

Sleep disordered breathing is common in patients with tetraplegia. Nocturnal arterial hypoxemia and sleep fragmentation due to sleep apnoea may be associated with cognitive dysfunction. We therefore studied the influence of sleep disordered breathing on neuropsychological function in 37 representative tetraplegic patients (mean age 34 +/- 9.7 years). Thirty percent (11 of 37 patients) had clinical...<br/><br/>D Sajkov, R Marshall, P Walker, I Mykytyn, R D McEvoy, J Wale, H Flavell, A T Thornton, R Antic (1998) <i>Spinal Cord</i> <i></i> <i></i> 36: 4 231-239<br/>

http://publicationslist.org/dimitar.sajkov/refid5 2007-08-30T00:45:13Z

Sleep-related respiratory disturbances are more common in men than in premenopausal women. This might, in part, be due to different susceptibilities to the respiratory depressant effects of hypoxia. Therefore, we compared ventilation during 10 min of baseline room-air breathing and 20-min sustained isocapnic hypoxia (fractional inspired O2 = 11%, arterial saturation of O2 approximately 80%) follow...<br/><br/>D Sajkov, A Neill, N A Saunders, R D McEvoy (1997) <i>J Appl Physiol</i> <i></i> <i></i> 83: 2 599-607<br/>

http://publicationslist.org/dimitar.sajkov/refid6 2007-08-30T00:45:13Z

STUDY OBJECTIVES AND PATIENTS: Pulmonary hypertension (PH) is common in COPD and may predict mortality in this disorder. We have compared the pulmonary vasodilator effects, dose-response characteristics, and tolerability of two calcium channel blockers, amlodipine and extended-release (ER) felodipine, in 10 patients (seven men, age 68+/-4.8 [SD] years) with clinically stable COPD and PH. DESIGN: D...<br/><br/>D Sajkov, T Wang, P A Frith, A J Bune, J A Alpers, R D McEvoy (1997) <i>Chest</i> <i></i> <i></i> 111: 6 1622-1630<br/>

http://publicationslist.org/dimitar.sajkov/refid8 2007-08-30T00:45:13Z

D Sajkov, R D McEvoy (1997) <i>Chest</i> <i></i> <i></i> 111: 1 256-257<br/>

http://publicationslist.org/dimitar.sajkov/refid7 2007-08-30T00:45:13Z

Changes in sleep posture have been shown to improve obstructive sleep apnea (OSA). To investigate the mechanisms by which this occurs we assessed upper airway stability in eight patients with severe OSA in three postures (supine, elevated to 30 degrees, and lateral). We used a specially adapted nasal continuous positive airway pressure (nCPAP) mask to measure upper airway closing pressure (UACP) a...<br/><br/>A M Neill, S M Angus, D Sajkov, R D McEvoy (1997) <i>Am J Respir Crit Care Med</i> <i></i> <i></i> 155: 1 199-204<br/>

http://publicationslist.org/dimitar.sajkov/refid9 2007-08-30T00:45:13Z

BACKGROUND--This study was undertaken to establish the prevalence of, and the factors contributing towards, sleep disordered breathing in patients with quadriplegia. METHODS--Forty representative quadriplegic patients (time since injury > 6 months, injury level C8 and above, Frankel category A, B, or C; mean (SE) age 35.0 (1.7) years) had home sleep studies in which EEG, EOG, submental EMG, body m...<br/><br/>R D McEvoy, I Mykytyn, D Sajkov, H Flavell, R Marshall, R Antic, A T Thornton (1995) <i>Thorax</i> <i></i> <i></i> 50: 6 613-619<br/>

http://publicationslist.org/dimitar.sajkov/refid10 2007-08-30T00:45:13Z

The gamma aminobutyric acid (GABA)-B agonist, baclofen, is a centrally-acting, anti-spasmodic agent and muscle relaxant used in spinal cord lesions, multiple sclerosis and other neurological disorders. In a previous pilot study of quadriplegic patients, 75% of whom were treated with baclofen, we found a high prevalence of sleep-disordered breathing. Because of the depressant effects of GABA on the...<br/><br/>A J Finnimore, M Roebuck, D Sajkov, R D McEvoy (1995) <i>Eur Respir J</i> <i></i> <i></i> 8: 2 230-234<br/>