http://publicationslist.org/data/ededkov/atom.xml Eduard Dedkovhttp://publicationslist.org/ededkov$basepathfavicon.icoRecent additions to Eduard Dedkov's PublicationsList.org pagehttp://publicationslist.org/publications.png2023-08-04T14:57:52Z http://publicationslist.org/ededkov/refid98 2023-08-04T14:57:24Z

Introduction: Infarcted myocardium follows a well-established sequence of reparative events resolving with scar formation. Several populations of resident and circulating cells as well as a range of signaling and regulatory molecules are implicated in this process, some of which are still not fully elucidated. Recently, much research has been done to develop therapies capable of modifying scar for...<br/><br/>Daniel Schneider, Eduard I Dedkov (2023) <i>Developmental Dynamics, 252 (7), Abstracts: 893</i><br/>

http://publicationslist.org/ededkov/refid97 2022-05-13T16:16:16Z

Introduction: A proper management of central blood pressure (cBP) has been recently recognized as a novel therapeutic target to reduce cardiovascular risks among hypertensive (HT) patients. Considering that the hypotensive action of most antihypertensive drugs does not persist after treatment interruption, the search for compounds which would permanently reduce the level of cBP remains vital. It h...<br/><br/>Eduard I Dedkov (2022) <i>The FASEB Journal, 36 (Supplement_1): R079</i><br/>

http://publicationslist.org/ededkov/refid95 2021-05-19T12:24:16Z

Introduction: Hypertension‐induced left ventricular (LV) hypertrophy and myocardial fibrosis provide structural basis for diastolic dysfunction. It has been previously reported that aldosterone receptor antagonist spironolactone (SL) can prevent myocardial fibrosis and, hence, alleviate hypertension‐induced diastolic dysfunction, whereas treatment with heart rate lowering drug ivabradine (IVA...<br/><br/>Eduard I Dedkov, Andrew T Milcarek (2021) <i>The FASEB Journal, 35 (Supplement_1): 1538</i><br/>

http://publicationslist.org/ededkov/refid94 2021-04-28T15:52:41Z

This study aimed to investigate the structural integrity and dynamic changes in chronically occluded residual arteries found in post–myocardial infarction (MI) scar. A transmural MI was induced in middle-aged, male Sprague-Dawley rats by left coronary artery ligation. The rats were euthanized 3 days and 1, 2, 4, 8, and 12 weeks after MI, and their hearts were processed into paraffin for histolog...<br/><br/>Eduard I Dedkov (2021) <i>Journal of Histochemistry & Cytochemistry </i> 69: 5 321-338<br/>

http://publicationslist.org/ededkov/refid96 2021-09-28T17:07:24Z

Background: Hypertension (HT)-induced accumulation of myocardial collagen stiffens the left ventricular (LV) wall and, hence, promotes diastolic dysfunction. Considering that a competitive aldosterone receptor antagonist spironolactone (SL) as well as a “pure” heart rate-lowering drug ivabradine (IVA) have both been proven to exert an anti-fibrotic effect during cardiac remodeling, we hypothes...<br/><br/>Eduard I Dedkov, Andrew T Milcarek (2021) <i>Hypertension. 2021;78 (Supplement_1): AP104</i><br/>

http://publicationslist.org/ededkov/refid92 2020-11-04T15:30:30Z

Introduction: Whereas considerable effort has been devoted to identify a suitable source of contractile cells to be used for replacement of a post‐myocardial infarction (MI) scar with the newly‐formed cardiac muscle tissue, an exploration for the viable routes of arterial blood supply to the sites of regenerating myocardium remained mostly neglected. However, the presence of a sustainable bloo...<br/><br/>Eduard I Dedkov (2020) <i>The FASEB Journal, 2020; 34, (1_Supplement): 87.2.</i><br/>

http://publicationslist.org/ededkov/refid93 2020-11-04T15:29:21Z

Background: Gamma-enolase, or neuron-specific enolase, is a multifunctional protein which is primarily found in neurons and neuroendocrine cells. Although the main role of gamma-enolase is associated with enzymatic activity during aerobic glycolysis, recently, it has been implicated in a variety of pathophysiological processes including inflammation, extracellular matrix degradation and cell survi...<br/><br/>Andrew T Milcarek, Eduard I Dedkov (2020) <i>Circulation Research, 2020; 127, Supplement_1: A323</i><br/>

http://publicationslist.org/ededkov/refid90 2019-03-27T18:41:35Z

Current understanding of the rewarding and addictive effects of opioids involves mu-opioid receptor (MOR) binding within the nucleus accumbens (NAcc), a region of the ventral striatum. GABAergic neurotransmission in the NAcc potentiates the rewarding response to opioids, and in fact, drugs that stimulate GABAergic activity are also addictive, a phenomenon mediated in part by endogenous opioids. Ho...<br/><br/>Chad Hinkle, Eduard Dedkov, Russell Buono, Thomas Ferraro (2019) <i>BioRxiv: 574434 </i><br/>

http://publicationslist.org/ededkov/refid91 2019-04-01T22:19:20Z

We have reported previously that local, patent microvascular networks support long-term survival of adult cardiac myocytes in subendocardial and subepicardial regions of large transmural post-myocardial infarction (MI) scars induced by left coronary artery ligation in middle-aged rats. According to our findings, such microvascular beds become perfused retrogradely from the left ventricular chamber...<br/><br/>Eduard I Dedkov (2019) <i>The FASEB Journal, 2019, 33 (1_Supplement): 770.3.</i><br/>

http://publicationslist.org/ededkov/refid86 2018-01-30T13:28:06Z

This study was aimed to understand the mechanism of persistent cardiac myocyte (CM) survival in myocardial infarction (MI) scars. A transmural MI was induced in 12-month-old Sprague-Dawley rats by permanent coronary artery ligation. The hearts were collected 3 days, 1, 2, 4, 8, and 12 weeks after MI and evaluated with histology, immunohistochemistry, and quantitative morphometry. Vasculature paten...<br/><br/>Colleen Nofi, Yevgen Bogatyryov, Eduard I Dedkov (2018) <i>Journal of Histochemistry and Cytochemistry</i> 66 (2): 99-120 <br/>

http://publicationslist.org/ededkov/refid87 2018-04-26T12:17:30Z

The presence of surviving cardiac myocytes in post-myocardial infarction (MI) scars has been repeatedly documented in humans as well as in various laboratory animals, particularly in rats. In the majority of cases, the long-term survival of cardiac myocytes in post-MI scars has been attributed either to continuing arterial blood supply from the bordering noninfarcted myocardium or to a rapid reest...<br/><br/>Colleen Nofi, and Eduard I. Dedkov (2018) <i>The FASEB Journal 2018, 32 (1_Supplement): 517.2.</i><br/>

http://publicationslist.org/ededkov/refid89 2018-11-05T19:01:13Z

Current understanding of the rewarding and addictive effects of opioids involves mu-opioid receptor (MOR) binding within the nucleus accumbens (NAcc), a region of the basal forebrain. GABA neurons in the NAcc are thought to function to potentiate the rewarding response to opioids, and in fact, drugs that generally stimulate GABAergic activity are also addictive, a phenomenon mediated in part by en...<br/><br/>Chad Hinkle, Thomas N. Ferraro, Eduard I. Dedkov, Russell J Buono (2018) <i>2018 Neuroscience Meeting Planner, Program No. 556.10. San Diego, CA: Society for Neuroscience </i><br/>

http://publicationslist.org/ededkov/refid88 2018-04-26T12:22:13Z

Introduction Chronic cervical vagus nerve stimulation has been introduced as a novel therapy for various diseases, including refractory epilepsy and chronic heart failure. Although it has been shown that the cervical vagus nerve contains sympathetic fibers, whether or not these sympathetic fibers innervate the heart is a subject of debate. Methods DiI, a plasma membrane lipophilic fluorescent...<br/><br/>Allan Migirov, John Siano, Eduard I. Dedkov, and Youhua Zhang (2018) <i>The FASEB Journal, 2018, 32 (1_Suppliment): 593.4. </i><br/>

http://publicationslist.org/ededkov/refid82 2016-11-29T13:35:57Z

Background Autonomic remodeling, characterized by sympathetic activation and vagal withdrawal, contributes to heart failure (HF) progression. However, the exact mechanism(s) responsible for vagal withdrawal in HF remain(s) unclear, and whether HF causes epicardial autonomic nerve remodeling is unknown. Methods and results Myocardial infarction (MI) was produced in 14 Sprague–Dawley rats, an...<br/><br/>Matthew S. Delfiner, John Siano, Ying Li, Eduard I. Dedkov, Youhua Zhang (2017) <i>Cardiovascular Pathology</i> 26: 21-29<br/>

http://publicationslist.org/ededkov/refid84 2018-01-23T14:06:38Z

A large myocardial infarction (MI) triggers progressive cardiac remodeling which results in left ventricular (LV) chamber dilatation and, as a consequence, in greater wall tension, particularly in the area of scar formation. Chronically elevated mechanical stress applied to fibroblasts and myofibroblasts within the scar has been known to stimulate the production of extracellular matrix proteins, p...<br/><br/>Eduard I. Dedkov, Robert J. Tomanek. (2017) <i>The FASEB Journal, 2017; 31 (1_Suppliment): 586.9.</i><br/>

http://publicationslist.org/ededkov/refid85 2018-01-23T14:08:09Z

Introduction: Heart failure (HF) results in autonomic dysfunction, characterized by sympathetic activation and vagal withdrawal, which in turn contributes to HF progression. The cardiac afferent sensory nerves play a critical role in mediating cardiovascular reflexes and in the neural regulation of cardiovascular function. However, the role of cardiac sensory nerves in mediating autonomic dysfunct...<br/><br/>John Siano, Ying Li, Eduard Dedkov, Youhua Zhang (2017) <i>The FASEB Journal, 2017, 31 (1_Suppliment): 844.7. </i><br/>

http://publicationslist.org/ededkov/refid79 2018-01-23T14:10:39Z

Heart rate reduction (HRR) induced in post-myocardial infarction (MI) rats by ivabradine, a selective inhibitor of the pacemaker If current, has been shown to attenuate left ventricular (LV) systolic dysfunction without affecting global cardiac remodeling. The functional improvement in post-MI hearts was associated with a marked inhibition of interstitial and perivascular fibrosis, and a significa...<br/><br/> Iosif Kandinov, Robert J Tomanek and Eduard I Dedkov (2016) <i>The FASEB Journal 2016; 30 (1_Supplement): 939.1. </i><br/>

http://publicationslist.org/ededkov/refid80 2018-01-23T14:09:40Z

Over the last several decades, a number of experimental studies have demonstrated that a large transmural post-myocardial infarction (MI) scar, primarily in rats, contains areas with surviving cardiac myocytes which are remotely separated from the remaining non-infarcted myocardium of the left ventricular (LV) free wall. However, until now, a little attention was paid to the condition of such card...<br/><br/>Colleen Nofi, Yevgen Bogatyryov and Eduard I Dedkov (2016) <i>The FASEB Journal 2016; 30 (1_Supplement): 1178.10.</i><br/>

http://publicationslist.org/ededkov/refid81 2016-11-29T13:36:52Z

We previously determined that residual left ventricular (LV) myocardium of middle-aged rats had sex-related differences in regional tissue properties 4 weeks after a large myocardial infarction (MI). However, the impact of such differences on cardiac performance remained unclear. Therefore, our current study aimed to elucidate whether sex-related changes in MI-induced myocardial remodeling can inf...<br/><br/>Eduard I. Dedkov, Yevgen Bogatyryov, Kristina Pavliak, Adora T. Santos, Yue-Feng Chen, Youhua Zhang, Alessandro Pingitore (2016) <i>Physiological Reports</i> 4(11): e12822<br/>

http://publicationslist.org/ededkov/refid83 2017-03-27T15:03:19Z

Introduction: Calcification of atherosclerotic plaques is associated with different histopathological and clinical manifestations. Microcalcification promotes inflammation and increases plaque instability, whereas macrocalcification is associated with stable fibroatheroma. The mechanisms of initiation and progression of calcification in atherosclerosis are not completely understood. Hypothesis: U...<br/><br/>Anthony Marco Corbo, Filippo Romanelli, Yuan Huang, Eduard I Dedkov, Jose Luis Millan, Alexei Y Savinov, Olga V Savinova (2016) <i> Arteriosclerosis, Thrombosis, and Vascular Biology 2016; 36 (1_Supplement): A462.</i><br/>

http://publicationslist.org/ededkov/refid75 2016-11-29T13:38:28Z

Background: A large myocardial infarction (MI) initiates progressive cardiac remodeling that leads to systolic heart failure (HF). Long-term heart rate reduction (HRR) induced by the I f current inhibitor ivabradine (IVA) ameliorates left ventricular (LV) remodeling and improves systolic performance in young post-MI rats. However, the beneficial effects of chronic IVA treatment in middle-aged rats...<br/><br/>Eduard I Dedkov, Yevgen Bogatyryov, Daniela Scaldaferri McCooey, Lance P. Christensen, Robert M. Weiss, Robert J. Tomanek (2015) <i>Journal of Cardiovascular Pharmacology and Therapeutics</i> 20 (3): 299-312<br/>

http://publicationslist.org/ededkov/refid77 2018-01-23T14:11:58Z

Our previous study on post-MI male and female middle-aged rats has revealed that although both sexes had a similar scale of LV remodeling, the females showed a greater density of cardiac myocytes in the epimyocardium. However, the mechanism of this structural alteration, as well as its impact on LV function, remained unclear. Our current study was aimed at determining whether the sex-specific diff...<br/><br/> Kristina Pavliak, Yue-Feng Chen, Alessandro Pingitore, Eduard I Dedkov (2015) <i>The FASEB Journal 2015; 29 (1_Supplement): 555.1. </i><br/>

http://publicationslist.org/ededkov/refid78 2015-09-16T17:34:43Z

Background: Cardiac autonomic dysfunction, characterized by sympathetic activation and vagal withdrawal, contributes to heart failure (HF) progression. However, the exact mechanism(s) responsible for vagal withdrawal in HF remain(s) unclear, and whether HF affects intrinsic epicardial autonomic innervation is unknown. The aim of the study is to investigate the intrinsic epicardial autonomic nerve ...<br/><br/>Matthew Delfiner, Eduard Dedkov, Ying Li, Youhua Zhang. (2015) <i>Autonomic Neuroscience: Basic and Clinical 2015; 192: 74-75. </i><br/>

http://publicationslist.org/ededkov/refid74 2018-01-23T14:12:43Z

Our previous study on post-MI male and female middle-aged rats has revealed the regional sex-specific differences in the adaptive changes of the left ventricular (LV) cardiac myocytes and coronary vessels. However, the impact of such structural alterations on LV systolic properties remained unclear. Therefore, our current study is aimed to determine whether post-MI cardiac remodeling in middle-age...<br/><br/>Eduard Dedkov, Adora Tricia Santos, Yevgen Bogatyryov, Yue-Feng Chen, Alessandro Pingitore (2014) <i>The FASEB Journal 2014, 28 (1_Supplement): 680.1</i><br/>

http://publicationslist.org/ededkov/refid73 2015-04-16T13:18:50Z

Background An increasing body of evidence indicates that left ventricular (LV) remodeling, especially the degree of reactive myocardial hypertrophy after myocardial infarction (MI), differs in males and females. Surprisingly, to date, the sex-specific post-MI alterations of the coronary vasculature remain undetermined. Therefore, we tested the hypothesis that adaptive coronary arteriolar and c...<br/><br/>Eduard I Dedkov, Kunal Oak, Lance P Christensen and Robert J Tomanek (2014) <i>Biology of Sex Differences </i> 5 (1): 1<br/>

http://publicationslist.org/ededkov/refid76 2016-11-29T13:39:08Z

Introduction: Heart failure (HF) is associated with increased atrial fibrillation (AF) risk. Accumulating evidence suggests the presence of myocardial tissue hypothyroidism in HF, which may contribute to HF development. Our recent report demonstrated that hypothyroidism, like hyperthyroidism, leads to increased AF inducibility. This study was designed to investigate the effect of thyroid hormone ...<br/><br/>Youhua Zhang, Eduard I. Dedkov, Bianca Lee, Ying Li, Khusbu Pun, A. Martin Gerdes (2014) <i>Journal of Cardiac Failure</i> 20 (12): 1012-1019<br/>

http://publicationslist.org/ededkov/refid67 2018-01-23T14:14:43Z

The current study investigates the spatio-temporal pattern of neuropeptide Y protein expression in coronary vessels and cardiac nerves during development of the mouse heart. The hearts of the C57BL/6 mice were collected on embryonic days 16 to 19 and on postnatal days 3 to 21. They were immersion-fixed with 4% PFA/PBS and processed for cryo-sectioning. The serial histological cross-sections t...<br/><br/>Anna Sverkunova, Eduard I Dedkov (2013) <i>The FASEB Journal 2013; 27: 529.6</i><br/>

http://publicationslist.org/ededkov/refid68 2018-01-23T14:14:13Z

Heart rate reduction (HRR) by ivabradine (IVA), a selective inhibitor of the pacemaker If current, for 4 weeks after myocardial infarction (MI) was associated with the reduced collagen accumulation in surviving left ventricular (LV) myocardium. Although this effect is considered to benefit LV performance, the decrease in fibrillar collagen (FC) can diminish a tensile strength of the scar. The...<br/><br/>Yevgen Bogatyryov, Daniela McCooey, Robert J Tomanek and Eduard I Dedkov (2013) <i>The FASEB Journal 2013; 27: 528.4</i><br/>

http://publicationslist.org/ededkov/refid69 2018-01-23T14:13:31Z

A large myocardial infarction (MI) initiates progressive structural remodeling that leads to a decline in left ventricular (LV) performance. Four weeks of heart rate reduction (HRR) in post-MI rats by ivabradine (IVA), a selective inhibitor of the pacemaker If current, attenuated LV systolic dysfunction without modifying cardiac remodeling. However, continuation of this beneficial effect after...<br/><br/>Daniela McCooey, Yevgen Bogatyryov, Robert J Tomanek and Eduard I Dedkov (2013) <i>The FASEB Journal 2013; 27: 528.5</i><br/>

http://publicationslist.org/ededkov/refid72 2015-04-16T13:19:02Z

BACKGROUND: -Evidence indicates that cardiac hypothyroidism may contribute to heart failure (HF) progression. It is also known that HF is associated with an increased risk of atrial fibrillation (AF). While it is established that hyperthyroidism increases AF incidence, the effect of hypothyroidism on AF is unclear. This study investigated the effects of different thyroid hormone levels, ranging...<br/><br/>Youhua Zhang, Eduard I. Dedkov, Diana Teplitsky, Nathan Y. Weltman, Christine J. Pol, Viswanathan Rajagopalan, Bianca Lee, A. Martin Gerdes (2013) <i>Circulation: Arrhythmia and Electrophysiology </i> 6: 952-959<br/>

http://publicationslist.org/ededkov/refid71 2016-11-29T13:40:17Z

The present study was designed to determine whether the structural composition of the scar in middle-aged post-myocardial infraction (MI) rats is affected by the biological sex of the animals. A large MI was induced in 12-month-old male (M-MI) and female (F-MI) Sprague-Dawley rats by ligation of the left coronary artery. Four weeks after the MI, rats with transmural infarctions, greater than 50% o...<br/><br/>Yevgen Bogatyryov, Robert J. Tomanek, Eduard I. Dedkov. (2013) <i>Journal of Histochemistry and Cytochemistry </i> 61 (11): 833-848<br/>

http://publicationslist.org/ededkov/refid70 2013-09-06T19:26:37Z

Background: We have previously shown that 1-month treatment with ivabradine (IVA), the selective cardiac pacemaker If current inhibitor, preserved myocardial perfusion and coronary perfusion reserve in post-MI middle-aged rats. However, the persistence of this cardioprotective effect after a prolonged period of IVA treatment remains to be determined. Methods: Acute MI was induced in 12-month-o...<br/><br/>Eduard I Dedkov, Yevgen Bogatyryov, Daniela McCooey, Lance P Christensen, Robert J Tomanek (2013) <i>Circulation Research 2013; 113 (4 Supplement): A067</i><br/>

http://publicationslist.org/ededkov/refid63 2018-01-23T14:15:24Z

A number of studies indicate that females have a better reparative response in earlier stages of myocardial infarction (MI) compared to males. Nevertheless, little is known concerning the sex-related differences in a later stage of MI healing (i.e. scar formation). Accordingly, we designed our study to determine whether the composition of the scar is affected by the biological sex of post-MI anima...<br/><br/>Yevgen Bogatyryov, Molly Kelly, Lance P Christensen, Robert J Tomanek, Eduard I Dedkov (2012) <i>FASEB J 2012; 26: 527.1.</i><br/>

http://publicationslist.org/ededkov/refid64 2012-08-30T16:15:36Z

Alessandro Pingitore, Eduard I Dedkov (2012) <i>Circulation Research 2012;111 (4): A269</i><br/>

http://publicationslist.org/ededkov/refid65 2012-08-30T16:15:50Z

Eduard I. Dedkov, Yevgen Bogatyryov, Kunal Oak, Lance P. Christensen, Robert J. Tomanek (2012) <i>Circulation Research 2012;111 (4): A240</i><br/>

http://publicationslist.org/ededkov/refid66 2015-04-16T13:19:50Z

D-dopachrome tautomerase is an enzyme related by amino acid sequence and catalytic activity to macrophage migration inhibitory factor. Both of these small molecules are pro-inflammatory cytokines mediating broad innate immune responses. Although it is well established that the gene product of D-dopachrome tautomerase is widely expressed in liver and kidney cells, no study has mapped the distributi...<br/><br/>Jared S. Honigman, Kristin M. DiGregorio, Eduard I. Dedkov, Joerg R. Leheste, Lin Leng, Richard Bucala, German Torres (2012) <i>Neuroscience</i> 226: 382-387<br/>

http://publicationslist.org/ededkov/refid29 2018-01-23T14:16:08Z

This study tested the hypothesis that selective blockade of neuropeptide Y (NPY) receptors Y1 and/or Y2 will affect the embryonic formation of coronary vessels induced by VEGF using an in vitro heart explant model. The ventricular apices from the hearts of C57BL/6 mouse embryos (E13) were placed on collagen I gel and cultured for 96 hrs in medium with 10% FBS. For the next 72 hrs the explants were...<br/><br/>Diana Teplitsky, Eduard I Dedkov (2011) <i>FASEB J 2011; 25: 684.3. </i><br/>

http://publicationslist.org/ededkov/refid28 2018-01-23T14:16:53Z

The current study investigates the expression patterns of the NPY-Y1 receptor (R)/Y2R system and VIP-VPAC1R/VPAC2R system in the developing coronary vessels of the quail embryonic heart. The hearts were collected from embryonic day (ED) 8 to ED16, fixed in 4% PFA/PBS and processed for cryosectioning. The serial histological cross-sections of the hearts were immunostained with rabbit polyclonal ant...<br/><br/>Molly Kelly, Eduard I. Dedkov (2011) <i>FASEB J 2011; 25: 684.4. </i><br/>

http://publicationslist.org/ededkov/refid31 2018-01-23T14:17:28Z

Increasing evidence indicates that sex can influence left ventricular (LV) remodeling after myocardial infarction (MI). The current study addressed coronary vasculature adaptations during post-infarction LV remodeling in 12-month-old female rats (MI-F) and compared the data with previous findings on age-matched males (MI-M). MI was induced by left coronary artery ligation and sham-operated rats se...<br/><br/>Eduard I Dedkov, Kunal Oak, Lance P Christensen, Robert J Tomanek (2010) <i>FASEB J 2010; 24: 1031.2.</i><br/>

http://publicationslist.org/ededkov/refid30 2012-03-14T13:26:17Z

Background: Cardiac remodeling after MI is associated with an increased incidence of heart failure. A number of previous animal studies have established that sex influences the severity of LV remodeling, suggesting a cardioprotective role of female sex hormones. Because most of these studies employed young or youngadult animals the data obtained may not be relevant to humans in which MI occu...<br/><br/>Eduard I Dedkov, Kunal Oak, Lance P Christensen, Robert J Tomanek (2010) <i>Basic Cardiovascular Sciences (BCVS) 2010 Scientific Sessions - Technological and Conceptual Advances in Cardiovascular Disease. Abstract Presentations: P21</i><br/>

http://publicationslist.org/ededkov/refid33 2018-01-23T14:18:08Z

We have previously demonstrated that VIP receptors are morphogenic modulators of embryonic coronary vessel tube formation in vitro. This study tested the hypothesis that a selective blockade of VIP receptors will affect formation and development of the coronary vessels in vivo. At embryonic day (ED) 5, 6, 7, and 8, a selective VIP receptor antagonist, VIP (6-28), was injected in ovo into the vitel...<br/><br/>Tatyana Krieger, Eduard I Dedkov (2009) <i>FASEB J 2009; 23: 642.4.</i><br/>

http://publicationslist.org/ededkov/refid32 2011-04-22T15:02:59Z

Background: We have previously demonstrated that long-term heart rate reduction (HRR) with ivabradine, a selective cardiac pacemaker I f current inhibitor, prevents myocardial fibrosis in post-infarcted middle-aged rats via limitation of the renin-angiotensin system (RAS). However, the effect of the more commonly used HRR drug atenolol on fibrosis and activity of the RAS in post-MI middle-aged...<br/><br/>Eduard I Dedkov, Joseph J Campanelli, Lance P Christensen, Robert J Tomanek (2009) <i>Circulation Research 2009; 105 (7): e22 (P63)</i><br/>

http://publicationslist.org/ededkov/refid1 2015-04-16T13:20:08Z

We compared the effects of heart rate reduction (HRR) by the hyperpolarization-activated pacemaker current (I(f)) channel inhibitor ivabradine (MI+Iva) and the beta(1)-blocker atenolol (MI+Aten) on ventricular remodeling and perfusion after myocardial infarction (MI) in middle-aged (12 mo) Sprague-Dawley rats. Mean HRR was virtually identical in the two treated groups (19%). Four weeks after coron...<br/><br/>Lance P Christensen, Ron-Ling Zhang, Wei Zheng, Joseph J Campanelli, Eduard I Dedkov, Robert M Weiss, Robert J Tomanek (2009) <i>Am J Physiol Heart Circ Physiol</i> <i></i> <i></i> 297 (1): H322-H330<br/>

http://publicationslist.org/ededkov/refid36 2011-04-22T15:22:16Z

We tested the hypothesis that VIP receptors, VPAC1 and VPAC2, are involved in morphogenic modulation of embryonic coronary vessel tube formation. Fertile Japanese quail eggs were used. At the developmental stage HH29, the hearts were excised and the ventricular apices were placed on collagen I gels in a 10% FBS medium. After 2 days, the explants were treated with VIP receptor selective agoni...<br/><br/>Eduard I DedkovI, Lance P Christensen, Robert J Tomanek (2008) <i>Angiogenesis 2008; 11 (2): 209 (067)</i><br/>

http://publicationslist.org/ededkov/refid35 2018-01-23T14:18:54Z

The inadequate growth of coronary resistance vessels (arterioles) during compensatory hypertrophy has been commonly considered the prime cause of impaired maximal perfusion in the LV myocardium after MI. However, our previous studies have shown that maximal coronary conductance (flow/pressure) was also reduced in the remote region of post-MI hearts that did not undergo compensatory hypertrophy. Ac...<br/><br/>Eduard I Dedkov, Wei Zheng, Lance P Christensen and Robert J Tomanek (2008) <i>FASEB J 2008; 22: 1152.1.</i><br/>

http://publicationslist.org/ededkov/refid34 2011-04-22T15:13:34Z

We compared the effects of heart rate reduction (HRR) by the If channel inhibitor, ivabradine (MI+IVA) and the β-blocker, atenolol (MI+ATEN) on ventricular remodeling and perfusion after myocardial infarction (MI). MI was induced in 12-mo.-old male Sprague-Dawley rats by left coronary artery ligation. Sham-operated rats (Sham) served as age-matched controls. Rats were treated for 1-4 weeks and th...<br/><br/>Robert J Tomanek, Lance P Christensen, R-L Zhang, Eduard Dedkov, Robert M Weiss (2008) <i>AHA Scientific Sessions 2008, e-Posters Archive: #1591 </i><br/>

http://publicationslist.org/ededkov/refid38 2011-04-22T15:36:54Z

This study assessed the impact of pure heart rate reduction (HRR) induced with ivabradine (IVA), a selective inhibitor of cardiac pacemaker If current, on left ventricular (LV) function, angiogenesis and coronary perfusion, in middle-aged postmyocardial infarction rats. MI was induced in 12-month-old male Sprague–Dawley rats by left coronary artery ligation. Post-MI rats received IVA (10.5...<br/><br/>Eduard I Dedkov, Wei Zheng, Lance P Christensen, Robert M Weiss, Robert J Tomanek (2007) <i>J Mol Cell Cardiol 2007; 42 (6), Suppl. 1: S206. </i><br/>

http://publicationslist.org/ededkov/refid39 2018-01-23T14:20:35Z

We tested the hypothesis that heart rate reduction induced in middle-aged post-MI rats can improve perfusion in the surviving LV myocardium by attenuating periarteriolar fibrosis. MI was induced in 12-month-old Sprague-Dawley rats, which were then treated either with ivabradine (MI+IVA) or placebo (MI) via osmotic pumps for 4 weeks. In addition, blood and tissue samples were obtained at 3, 7 and 1...<br/><br/>Eduard I Dedkov, Wei Zheng, Lance P Christensen, Robert M Weiss, Florence Mahlberg-Gaudin and Robert J Tomanek (2007) <i>FASEB J 2007; 21 (6) Part II: A973 (778.3). </i><br/>

http://publicationslist.org/ededkov/refid26 2015-04-16T19:12:01Z

The field of angiogenesis continues to rapidly evolve in many different directions. Initial discoveries of a few angiogenic growth factors, such as vascular endothelial growth factors (VEGF), fibroblast growth factors (FGF) and angiopoietins, gave an impression of a relatively uncomplicated system with a few straightforward regulatory mechanisms revolving around hypoxia and inflammation. However, ...<br/><br/>Robert J Tomanek, Eduard I Dedkov (2007) <i>Modern Concepts in Angiogenesis.</i> 253-280<br/>

http://publicationslist.org/ededkov/refid40 2018-01-23T14:20:01Z

In order to maintain a normal coronary reserve following a myocardial infarction, the surviving hypertropic myocardium must undergo vascular growth. This response requires upregulation of multiple growth factors. Although gene therapy has some promise in this regard, this approach usually focuses on a single growth factor. This presentation reviews the evidence that mechanical factors are key prim...<br/><br/>Robert J. Tomanek, Eduard Dedkov and Wei Zheng (2007) <i>FASEB J 2007; 21 (5) Part I: A80 (184.3).</i><br/>

http://publicationslist.org/ededkov/refid37 2011-04-22T15:29:59Z

Background: Heart rate reduction (HRR) after myocardial infarction (MI) in young rats stimulates angiogenesis, attenuates the decline in left ventricular (LV) function and coronary perfusion. However, the impact of lowering heart rate on older rats needs to be clarified. Accordingly, we tested the hypothesis that HRR in middle-aged post-MI rats induced with ivabradine (IVA), the first and sele...<br/><br/>Eduard I Dedkov, Wei Zheng, Lance P Christensen, Robert M Weiss, Florence Mahlberg-Gaudin, Robert J Tomanek (2007) <i>Eur Heart J 2007; 28 (Suppl. 1): 670-671 (P4023).</i><br/>

http://publicationslist.org/ededkov/refid2 2015-04-16T13:20:53Z

Syndecan-4 and its cytoplasmic binding partner, synectin, are known to play a role in FGF-2 signaling and vascular growth. To determine their roles in coronary artery/arteriolar formation and growth, we compared syndecan-4 and synectin null mice with their wild-type counterparts. Image analysis of arterioles visualized by smooth muscle alpha-actin immunostaining revealed that synectin (-/-) mice h...<br/><br/>Eduard I Dedkov, Mathew T Thomas, Milan Sonka, Fuxing Yang, Thomas W Chittenden, John M Rhodes, Michael Simons, Erik L Ritman, Robert J Tomanek (2007) <i>Dev Dyn</i> <i></i> <i></i> 236 (7): 2004-2010<br/>

http://publicationslist.org/ededkov/refid3 2015-04-16T13:20:38Z

We tested the hypothesis that chronically reducing the heart rate in infarcted middle-aged rats using ivabradine (IVA) would induce arteriolar growth and attenuate perivascular collagen and, thereby, improve maximal perfusion and coronary reserve in the surviving myocardium. Myocardial infarction (MI) was induced in 12-mo-old male Sprague-Dawley rats, which were then treated with either IVA (10.5 ...<br/><br/>Eduard I Dedkov, Wei Zheng, Lance P Christensen, Robert M Weiss, Florence Mahlberg-Gaudin, Robert J Tomanek (2007) <i>Am J Physiol Heart Circ Physiol</i> <i></i> <i></i> 293 (1): H590-H598<br/>

http://publicationslist.org/ededkov/refid4 2015-04-16T13:20:22Z

Leptofibrils, or leptomeres, remain the least studied cytoskeletal structures in muscle cells, and their function and mechanism of assembly are still poorly understood. Our ultrastructural study of the surviving cardiac myocytes located in the perinecrotic border zone of the infarcted left ventricle in rats revealed intense formation of leptofibrils and leptofibrillar clusters during 4-15 days fol...<br/><br/>Eduard I Dedkov, Alexander A Stadnikov, Mark W Russell, Andrei B Borisov (2007) <i>Micron</i> <i></i> <i></i> 38 (6): 659-667<br/>

http://publicationslist.org/ededkov/refid7 2015-04-16T13:21:36Z

Branching morphogenesis is a key process in the formation of vascular networks. To date, little is known regarding the molecular events regulating this process. We investigated the involvement of synectin in this process. In zebrafish embryos, synectin knockdown resulted in a hypoplastic dorsal aorta and hypobranched, stunted, and thin intersomitic vessels due to impaired migration and proliferati...<br/><br/>Thomas W Chittenden, Filip Claes, Anthony A Lanahan, Monica Autiero, Robert T Palac, Eugene V Tkachenko, Arye Elfenbein, Carmen Ruiz de Almodovar, Eduard Dedkov, Robert Tomanek, Weiming Li, Michael Westmore, Jai Pal Singh, Arie Horowitz, Mary Jo Mulligan-Kehoe, Karen L Moodie, Zhen W Zhuang, Peter Carmeliet, Michael Simons (2006) <i>Dev Cell</i> <i></i> <i></i> 10 (6): 783-795<br/>

http://publicationslist.org/ededkov/refid6 2015-04-16T13:21:49Z

BACKGROUND: Despite an appreciable increase in basal coronary blood flow in cyanotic congenital heart disease, flow reserve remains normal. We hypothesized that preservation of flow reserve resides in remodeling of the coronary microcirculation. Microcirculatory morphometric analyses were performed to test this hypothesis. METHODS AND RESULTS: Necropsy specimens from 4 sources were studied: (1) he...<br/><br/>Eduard I Dedkov, Joseph K Perloff, Robert J Tomanek, Michael C Fishbein, David D Gutterman (2006) <i>Circulation</i> <i></i> <i></i> 114 (3): 196-200<br/>

http://publicationslist.org/ededkov/refid5 2015-04-16T13:22:01Z

Recent studies have provided insights into specific events that contribute to vasculogenesis and angiogenesis in the developing coronary vasculature. This study focused on the developmental progression of coronary vascularization beginning with tube formation and ending with the establishment of a coronary arterial tree. We used electron microscopy, histology of serial sections, and immunohistoche...<br/><br/>Robert J Tomanek, Heidi K Hansen, Eduard I Dedkov (2006) <i>Anat Rec A Discov Mol Cell Evol Biol</i> <i></i> <i></i> 288 (9): 989-999<br/>

http://publicationslist.org/ededkov/refid8 2015-04-16T13:21:21Z

Previous studies have not addressed regional differences in adaptive arteriolar growth in the surviving left ventricular (LV) myocardium after infarction in appropriately aged animals, namely middle-aged or older. Accordingly, we examined the adaptive postinfarction growth of arterioles in two distinct regions, i.e., the LV free wall (LVFW) and septum, of middle-aged rats. We induced a myocardial ...<br/><br/>Eduard I Dedkov, Wei Zheng, Robert J Tomanek (2006) <i>Am J Physiol Heart Circ Physiol</i> <i></i> <i></i> 291 (4): H1686-H1693<br/>

http://publicationslist.org/ededkov/refid9 2015-04-16T13:21:08Z

OBJECTIVE: Peripheral blood contains primitive (stem cell-like) and monocytic-like endothelial cell progenitors. Diabetes apparently converts these primitive progenitors, from a pro-angiogenic to anti-angiogenic phenotype. Monocytic progenitors seem to be less affected by diabetes, but potential pro-angiogenic activities of freshly isolated monocytic progenitors remain unexplored. We compared the ...<br/><br/>Ola Awad, Eduard I Dedkov, Chunhua Jiao, Steven Bloomer, Robert J Tomanek, Gina C Schatteman (2006) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 26 (4): 758-764<br/>

http://publicationslist.org/ededkov/refid42 2018-01-23T14:21:17Z

This study tested the hypothesis that selective activation or blockade of VIP1 and VIP2 receptors will affect embryonic coronary vessel tube formation. The in vitro quail heart explant model was used. The ventricular apices from the hearts (stage HH29) were placed on collagen I gel and cultured for 48 hr in the medium with 10% FBS. For the next 48 hr, the explants were treated with the VIP recepto...<br/><br/>Eduard I Dedkov , Lance P Christensen and Robert J Tomanek (2006) <i>FASEB J 2006; 20 (4) Part I: A440 (303.7).</i><br/>

http://publicationslist.org/ededkov/refid41 2016-01-26T14:08:49Z

Background: Basal coronary blood flow is increased in adults with cyanotic congenital heart disease (CCHD), but hyperemic flow and flow reserve remain normal. Since the extramural coronary arteries in CCHD are maximally dilated, we hypothesized that preservation of hyperemic flow and flow reserve resides in the coronary microvasculature. Methods: To distinguish coronary microvascular adaptive resp...<br/><br/>Eduard I Dedkov; Joseph K Perloff; Robert J Tomanek; Michael C Fishbein; David D Gutterman (2006) <i>Circulation 2006; 114 (18), Suppl. II: II-384 (1928).</i><br/>

http://publicationslist.org/ededkov/refid43 2011-04-22T15:55:38Z

Chittenden TW, Claes F, Lanahan AA, Autiero M, Palac RT, Elfenbein A, Drinane M, Dedkov E, Tomanek R, Singh JP, Zhuang ZW, Carmeliet P, Simons M. (2005) <i>Circulation 2005; 112 (17), Suppl. II: II-135 (733)</i><br/>

http://publicationslist.org/ededkov/refid44 2018-01-23T14:22:02Z

This study tested the hypothesis that long-term heart-rate reduction induced by Ivabradine (IVA) promotes growth of coronary resistance vessels after experimental myocardial infarction (MI) in middle-aged rats. Three groups of 12-month-old Sprague- Dawley rats were used: 1) Sham (SH), 2) MI, 3) MI+IVA. Antero-apical MI of the left ventricle (LV) was induced by proximal occlusion of the LAD art...<br/><br/>Eduard I DedkovI, Lance P Christensen, Florence Mahlberg-Gaudin, Robert J Tomanek (2005) <i>FASEB J 2005; 19 (4) Part I: A235 (194.8)</i><br/>

http://publicationslist.org/ededkov/refid11 2015-04-16T19:08:08Z

Little is known about the biological properties of myogenic satellite cells during post-denervation muscle atrophy. The present study investigated the differentiative capacity of satellite cells and their involvement in the compensatory regenerative process in long-term denervated rat muscle. Electron microscopy and immunocytochemical labeling of muscle tissue 1-18 months following denervation dem...<br/><br/>Andrei B Borisov, Eduard I Dedkov, Bruce M Carlson (2005) <i>Anat Embryol (Berl)</i> <i></i> <i></i> 209 (4): 269-279<br/>

http://publicationslist.org/ededkov/refid12 2015-04-16T13:22:21Z

Adequate growth of coronary vasculature in the remaining left ventricular (LV) myocardium after myocardial infarction (post-MI) is a crucial factor for myocyte survival and performance. We previously demonstrated that post-MI coronary angiogenesis can be stimulated by bradycardia induced with the ATP-sensitive K(+) channel antagonist alinidine. In this study, we tested the hypothesis that heart ra...<br/><br/>Eduard I Dedkov, Lance P Christensen, Robert M Weiss, Robert J Tomanek (2005) <i>Am J Physiol Heart Circ Physiol</i> <i></i> <i></i> 288 (6): H2684-H2693<br/>

http://publicationslist.org/ededkov/refid10 2015-04-16T19:08:23Z

Satellite cells represent a cellular source of regeneration in adult skeletal muscle. It remains unclear why a large pool of stem myoblasts in denervated muscle does not compensate for the loss of muscle mass during post-denervation atrophy. In this study, we present evidence that satellite cells in long-term denervated rat muscle are able to activate synthesis of contractile proteins after single...<br/><br/>Andrei B Borisov, Eduard I Dedkov, Bruce M Carlson (2005) <i>Histochem Cell Biol</i> <i></i> <i></i> 124 (1): 13-23<br/>

http://publicationslist.org/ededkov/refid48 2011-04-22T16:07:50Z

To elucidate function of synectin (PDZ2 scaffold protein) in vivo, we have generated synectin-/- mice using an exon trap approach. The synectin-/- mice are viable, but are significantly smaller than wild type controls (Table). Coronary angiography demonstrated reduced branching of epicardial coronary arteries in the synectin-/- mice compared to wild type (WT). To further address the issues of intr...<br/><br/>T. Chittenden, E. DeMunick, A. Lanahan, R. Palac, E. Dedkov, R. Tomanek and M. Simons (2004) <i>FASEB J 2004; 18 (5): A1014 (672.12)</i><br/>

http://publicationslist.org/ededkov/refid46 2011-04-22T16:03:24Z

Chittenden TW, Lanahan A, Drinane M, Zhuang ZW, Moodie K, deMuinck ED, Helisch A, Palac RT, Mulligan-Kehoe MJ, Dedkov E, Tomanek R, Simons M. (2004) <i>Circulation 2004; 110 (17), Suppl. S: 172</i><br/>

http://publicationslist.org/ededkov/refid45 2011-04-22T16:03:54Z

Chittenden T, DeMuinck E, Palac R, Dedkov E, Tomanek R, Simons M. (2004) <i>J Mol Cell Cardiol 2004; 37 (1): 356</i><br/>

http://publicationslist.org/ededkov/refid47 2011-04-22T16:06:17Z

This study tested the hypothesis that chronic bradycardia induced by Atenolol (AT) may trigger compensatory coronary angiogenesis after acute experimental myocardial infarction (MI). Three groups of adult Sprague-Dawley rats were used: 1) control, 2) MI, 3) MI/AT-treated. MI was induced by surgical occlusion of the anterior descending branch of left coronary artery. AT was administered in drinking...<br/><br/>Eduard I Dedkov, Lance P Christensen, Robert J Tomanek (2004) <i>FASEB J 2004; 18 (5): A777 (533.7)</i><br/>

http://publicationslist.org/ededkov/refid16 2015-04-16T19:08:52Z

PURPOSE: This study was designed to determine whether the quantitative relationship between the levels of the eEF1A-1(developmental) and eEF1A-2/S1 (adult) isoforms of peptide elongation factor remains stable after denervation of skeletal muscle or whether in response to denervation the relative amount of the developmental form would increase. In normal postnatal rat muscle, eEF1A-2/S1 is the domi...<br/><br/>Abdelnaby Khalyfa, Bruce M Carlson, Eduard I Dedkov, Eugenia Wang (2003) <i>Restor Neurol Neurosci</i> <i></i> <i></i> 21 (1-2): 47-53<br/>

http://publicationslist.org/ededkov/refid15 2015-04-16T19:09:10Z

Satellite cells (SCs) are the main source of new fibers in regenerating skeletal muscles and the key contributor to extra nuclei in growing fibers during postnatal development. Aging results in depletion of the SC population and in the reduction of its proliferative activity. Although it has been previously determined that under conditions of massive fiber death in vivo the regenerative potential ...<br/><br/>Eduard I Dedkov, Andrei B Borisov, Anton Wernig, Bruce M Carlson (2003) <i>J Histochem Cytochem</i> <i></i> <i></i> 51 (7): 853-863<br/>

http://publicationslist.org/ededkov/refid13 2015-04-16T19:09:35Z

We investigated the dynamics of muscle fiber atrophy in denervated fast and slow muscles of young and old rats. Hind limbs of 4-month-old and 24-month-old male rats were denervated, and soleus and tibialis anterior muscles were examined morphometrically 1 and 2 months after denervation. In all denervated muscles, type II muscle fibers underwent rapid atrophy, although muscle-specific differences i...<br/><br/>Eduard I Dedkov, Andrei B Borisov, Bruce M Carlson (2003) <i>J Gerontol A Biol Sci Med Sci</i> <i></i> <i></i> 58 (11): 984-991<br/>

http://publicationslist.org/ededkov/refid17 2015-04-16T19:08:40Z

We analyzed the level of protein expression of two myogenic regulatory factors (MRFs), MyoD and myogenin, in senile skeletal muscles and determined the cellular source of their production in young adult (4 months old), old (24, 26, and 28 months old), and senile (32 months old) male rats. Immunoblotting demonstrated levels of myogenin approximately 3.2, approximately 4.0, and approximately 5.5 tim...<br/><br/>Eduard I Dedkov, Tatiana Y Kostrominova, Andrei B Borisov, Bruce M Carlson (2003) <i>Cell Tissue Res</i> <i></i> <i></i> 311 (3): 401-416<br/>

http://publicationslist.org/ededkov/refid14 2015-04-16T19:09:22Z

Caveolin-3, a muscle-specific member of the caveolin family, is strongly localized to the neuromuscular junction (NMJ) in adult rat muscle fibers, where it co-localizes with alpha-bungarotoxin staining. In 24-month-old rats, less distinct staining corresponds with the normal aging changes in the NMJ. After denervation, the pattern and intensity of staining begin to break up as early as 3 days, and...<br/><br/>Bruce M Carlson, Jean A Carlson, Eduard I Dedkov, Ian S McLennan (2003) <i>J Histochem Cytochem</i> <i></i> <i></i> 51 (9): 1113-1118<br/>

http://publicationslist.org/ededkov/refid49 2011-04-22T16:10:44Z

The aim of our study was to determine the effect of innervation on the mitotic activity in uMPCs associated with new fibers in the regenerating EDL muscles. Two groups of 4-month-old rats were used. In both groups, muscle regeneration was induced by the injection of Marcaine. In one group, muscle regeneration was combined with denervation caused by transection of the sciatic nerve. Innervated and ...<br/><br/>Eduard I Dedkov, Bruce M Carlson (2003) <i>FASEB J 2003: 17 (5), Part II: A781 (468.21)</i><br/>

http://publicationslist.org/ededkov/refid50 2011-04-22T16:13:28Z

The aims of our study were to determine a cellular source of elevated MyoD and myogenin protein expression in senile skeletal muscles and to provide a potential explanation for this phenomenon. Our research was conducted on WI/HicksCar rats 4 (young), 24 (old), and 32 (senile) months of age. Compared to young animals, protein levels of MyoD and myogenin are increased in gastrocnemius muscles of ol...<br/><br/>Eduard I Dedkov, Tatiana Y Kostrominova, Andrei B Borisov, Bruce M Carlson (2002) <i>FASEB J 2002; 16 (4), Part I: A390</i><br/>

http://publicationslist.org/ededkov/refid56 2011-04-22T16:27:38Z

Bruce M Carlson, Andrei Borisov, Eduard Dedkov, Tatiana Kostrominova (2002) <i>Proceedings of the Georgian Academy of Sciences, Biological series A </i> S51-S55<br/>

http://publicationslist.org/ededkov/refid27 2015-04-16T19:09:44Z

Mammalian skeletal muscle undergoes profound atrophy after denervation. The functional restoration of denervated muscle is a significant clinical problem, and the success of restorative attempts decreases substantially after several months of denervation. Rat extensor digitorum longus muscles are capable of excellent restoration for the first 2-3 months after denervation, but after that time...<br/><br/> Bruce M. Carlson, Andrei B. Borisov, Eduard I Dedkov, Douglas Dow, Tatiana Y Kostrominova (2002) <i>Basic and Applied Myology </i> 12 (6): 247-254<br/>

http://publicationslist.org/ededkov/refid52 2011-04-22T16:16:38Z

Kostrominova TY, Macpherson PCD, Dedkov EI, Carlson BM, Goldman D. (2002) <i>FASEB J 2002: 16 (4), Part I: A390</i><br/>

http://publicationslist.org/ededkov/refid20 2015-04-16T19:09:57Z

In denervated skeletal muscles, atrophy of muscle fibers and interstitial fibrosis are associated with alterations within the vascular bed. Our study has placed particular emphasis on changes occurring in resistance vessels and the microcirculatory bed of rat hindlimb skeletal muscles that had been denervated for 25 months. We found that the tunica media of the majority of long-term denervated res...<br/><br/>Eduard I Dedkov, Tatiana Y Kostrominova, Andrei B Borisov, Bruce M Carlson (2002) <i>Microvasc Res</i> <i></i> <i></i> 63 (1): 96-114<br/>

http://publicationslist.org/ededkov/refid18 2015-04-16T19:10:23Z

We compared the reactions to denervation of limb muscles between young adult and old rats. After denervation for up to 4 months in 24-month-old rats, limb muscles were removed and analyzed for contractile properties, morphology, and levels of several key molecules, including the peptide elongation factors eEF1A-1 and eEF1A-2/S1, myogenin, gamma-subunit of the acetylcholine receptor, and cyclin D3....<br/><br/>Bruce M Carlson, Andrei B Borisov, Eduard I Dedkov, Abdelnaby Khalyfa, Tatiana Y Kostrominova, Peter C D Macpherson, Eugenia Wang, John A Faulkner (2002) <i>J Gerontol A Biol Sci Med Sci</i> <i></i> <i></i> 57 (10): B366-B374<br/>

http://publicationslist.org/ededkov/refid19 2015-04-16T19:10:11Z

It is well established that over time Schwann cells disappear from the endoneurial space of the distal stump of a chronically transected sciatic nerve trunk. Nevertheless, the status of the Schwann cells within terminal branches of the transected sciatic nerve remains poorly understood. To elucidate this issue we examined the endoneurial space of the intramuscular nerves in rat hindlimb skeletal m...<br/><br/>Eduard I Dedkov, Tatiana Y Kostrominova, Andrei B Borisov, Bruce M Carlson (2002) <i>Acta Neuropathol</i> <i></i> <i></i> 103 (6): 565-574<br/>

http://publicationslist.org/ededkov/refid21 2015-04-16T19:11:01Z

Little is known concerning the time-course and structural dynamics of reactivation of compensatory myogenesis in denervated muscle, its initiating cellular mechanisms, and the relationship between this process and the progression of postdenervation atrophy. The purpose of this study was to investigate the interrelations between temporal and spatial patterns of the myogenic response in denervated m...<br/><br/>Andrei B Borisov, Eduard I Dedkov, Bruce M Carlson (2001) <i>Anat Rec</i> <i></i> <i></i> 264 (2): 203-218<br/>

http://publicationslist.org/ededkov/refid22 2015-04-16T19:10:50Z

This study, conducted on 25-month denervated rat hindlimb muscles, was directed toward elucidating the basis for the poor regeneration that is observed in long-term denervated muscles. Despite a approximately 97.6% loss in mean cross-sectional area of muscle fibers, the muscles retained their fascicular arrangement, with the fascicles containing approximately 1.5 times more fibers than age-matched...<br/><br/>Eduard I Dedkov, Tatiana Y Kostrominova, Andrei B Borisov, Bruce M Carlson (2001) <i>Anat Rec</i> <i></i> <i></i> 263 (2): 139-154<br/>

http://publicationslist.org/ededkov/refid23 2015-04-16T19:10:37Z

This study was undertaken to assess the regenerative capacity of skeletal muscle in rats near the end of their normal life span. Two experiments were performed. In the first, extensor digitorum longus (EDL) muscles were cross-age transplanted from 32-month-old male inbred Wistar (WI/HicksCar) rats in place of an EDL muscle in 4-month-old hosts. The other EDL muscle in the hosts was autotransplante...<br/><br/>Bruce M Carlson, Eduard I Dedkov, Andrei B Borisov, John A Faulkner (2001) <i>J Gerontol A Biol Sci Med Sci</i> <i></i> <i></i> 56 (5): B224-B233<br/>

http://publicationslist.org/ededkov/refid53 2011-04-22T16:18:48Z

Eduard I Dedkov, Andrei B Borisov, Bruce M Carlson (2001) <i>FASEB J 2001; 15 (4), Part I: A420</i><br/>

http://publicationslist.org/ededkov/refid55 2011-04-22T16:24:29Z

Bruce M Carlson, Andrei B Borisov, Jean A Carlson, Eduard Dedkov, John A Faulkner, Tatiana Y Kostrominova (2000) <i> The Proceedings of 5th International Muscle Symposium.</i> 93-95<br/>

http://publicationslist.org/ededkov/refid54 2018-08-23T19:33:51Z

Eduard I Dedkov, Tatiana Y Kostrominova, Andrei B Borisov, Bruce M Carlson (2000) <i>FASEB J 2000; 14 (4), Part I: A281</i><br/>

http://publicationslist.org/ededkov/refid57 2011-04-22T16:29:11Z

Andrei B Borisov, Eduard I Dedkov, Bruce M Carlson (1999) <i>FASEB J 1999; 13 (4), Part I: A409</i><br/>

http://publicationslist.org/ededkov/refid58 2011-04-22T16:31:44Z

Bruce M Carlson, Eduard Dedkov, John A Faulkner (1999) <i>FASEB 1999 meeting; Late-Breaking Abstracts: LB73</i><br/>

http://publicationslist.org/ededkov/refid61 2011-04-22T16:43:42Z

Bruce M Carlson, Andrei B Borisov, Eduard Dedkov, Joseph O Nnodim (1998) <i>Postnatal Myogenesis: Satellite Cells in Action! </i> 32<br/>

http://publicationslist.org/ededkov/refid60 2011-04-22T16:36:01Z

Eduard I Dedkov, Andrei B Borisov, Bruce M Carlson (1998) <i>FASEB J 1998; 12 (5), Part II: A666</i><br/>

http://publicationslist.org/ededkov/refid59 2011-04-22T16:34:04Z

The purpose of the present study was to investigate the dependence of remodeling of intercalated discs (ID) and assembly of myofibrils (AM) in cardiac muscle on the presence of myocyte-myocyte contacts. We studied these processes in two experimental models: (1) long-term cell cultures of neonatal and adult rat cardiomyocytes plated at densities that ensured or prevented the formation of contacts b...<br/><br/>Andrei B Borisov, Eduard I Dedkov (1998) <i>FASEB J 1998; 12 (4), Part I: A72</i><br/>

http://publicationslist.org/ededkov/refid62 2011-04-22T16:45:21Z

Stadnikov AA, Dedkov EI, Kovbyk LV, Kozlova AN, Zavershinskaya LI. (1997) <i>The Society for Neuroscience 27th Annual Meeting Abstracts 1997; 23, Part II: 1453.</i><br/>

http://publicationslist.org/ededkov/refid24 2015-04-16T19:11:11Z

Morpho-functional changes of left ventricle myocardium were studied in 30 adult male rats by the method of subcutaneous implantation of diffusion chambers. The transplants were examined in 1, 3, 6, 8 and 10 days after the beginning of cultivation. The method of light microscopy at the 1-2 microm sections was used after histological processing of specimens for the identification of muscle and non-m...<br/><br/>Eduard I Dedkov (1995) <i>Morfologiia</i> <i></i> <i></i> 108 (2): 46-48<br/>

http://publicationslist.org/ededkov/refid25 2015-04-16T19:11:24Z

60 implantes of the left atrium myocardium were studied on the 1st, 3rd and 6th days of in vivo culture according to F. M. Lazarenko method (outbred laboratory male rats of 200-250g. body weight were used both as donors and recipients). Reactive changes of the cultured cardiomyocytes were assessed by methods of light and electron microscopy. Polymorphic nature of the cardiomyocyte reactive changes...<br/><br/>Alexander A Stadnikov, Eduard I Dedkov (1994) <i>Morfologiia</i> <i></i> <i></i> 106 (4-6): 124-129<br/>