http://publicationslist.org/data/eirik.solheim/atom.xml Eirik Solheimhttp://publicationslist.org/eirik.solheim$basepathfavicon.icoRecent additions to Eirik Solheim's PublicationsList.org pagehttp://publicationslist.org/publications.png2011-09-14T06:07:52Z http://publicationslist.org/eirik.solheim/refid39 2011-03-19T19:13:45Z

Jesper Blomquist, Eirik Solheim, Sigurd Liavaag, Cecilie P Schroder, Birgitte Espehaug, Leif I Havelin (2011) <i>Acta Ortopaedica (in press)</i> : <br/>

http://publicationslist.org/eirik.solheim/refid40 2011-06-11T13:14:30Z

PURPOSE: The objectives of this study were to evaluate the results in the outpatient treatment of recalcitrant lateral epicondylitis with release of the common extensor origin according to Hohmann and to determine any prognostic factors. METHODS: Eighty tennis elbows in 77 patients with a characteristic history of activity-related pain at the lateral epicondyle interfering with the activities of d...<br/><br/>Eirik Solheim, Janne Hegna, Jannike Øyen (2011) <i>Knee Surg Sports Traumatol Arthrosc</i> 19: 6 1023-7<br/>

http://publicationslist.org/eirik.solheim/refid38 2010-05-09T10:04:10Z

We compared the results of microfracture in single versus multiple symptomatic articular cartilage defects in the knee in 110 patients with a median age of 38 years (range 15-60). Cases of reoperation of the cartilage defect were classified as failures. Clinical outcome in non-failures was evaluated by the Lysholm score and grading of knee pain and function of the knee by the use of patient-admini...<br/><br/>Eirik Solheim, Jannike Øyen, Janne Hegna, Ove K Austgulen, Thomas Harlem, Torbjørn Strand (2010) <i>Knee Surg Sports Traumatol Arthrosc</i> <i></i> <i></i> 18: 4 504-508<br/>

http://publicationslist.org/eirik.solheim/refid1 2010-05-09T10:04:10Z

We evaluated short- and medium-term results of the treatment of articular cartilage defects of the knee with autogenous cylindrical osteochondral grafts (mosaicplasty) in 69 patients (median age 33 years) with symptomatic articular cartilage defects. Data of Lysholm score and visual analogue scale (VAS) of pain (0=no pain; 100=worst possible pain) were collected before the surgery, at 12 months po...<br/><br/>Eirik Solheim, Janne Hegna, Jannike Oyen, Ove Kristian Austgulen, Thomas Harlem, Torbjørn Strand (2010) <i>Knee</i> <i></i> <i></i> 17: 1 84-87<br/>

http://publicationslist.org/eirik.solheim/refid2 2009-08-14T11:53:32Z

BACKGROUND: The optimal treatment for cartilage lesions has not yet been established. The objective of this randomized trial was to compare autologous chondrocyte implantation with microfracture. This paper represents an update, with presentation of the clinical results at five years. METHODS: Eighty patients who had a single chronic symptomatic cartilage defect on the femoral condyle in a stable ...<br/><br/>Gunnar Knutsen, Jon Olav Drogset, Lars Engebretsen, Torbjørn Grøntvedt, Vidar Isaksen, Tom C Ludvigsen, Sally Roberts, Eirik Solheim, Torbjørn Strand, Oddmund Johansen (2007) <i>J Bone Joint Surg Am</i> <i></i> <i></i> 89: 10 2105-2112<br/>

http://publicationslist.org/eirik.solheim/refid3 2009-08-14T11:53:32Z

BACKGROUND: Frozen shoulder is a debilitating, long-lasting condition. At Bergen Surgical Hospital we have performed arthroscopic capsular release since 2003 in patients where conservative treatment has failed. The procedure is done as day surgery. The purpose of this study was to evaluate our results. PATIENTS AND METHODS: From June 2003 until October 2005 arthroscopic capsular and ligament relea...<br/><br/>Ove Kristian Austgulen, Jannike Øyen, Janne Hegna, Eirik Solheim (2007) <i>Tidsskr Nor Laegeforen</i> <i></i> <i></i> 127: 10 1356-1358<br/>

http://publicationslist.org/eirik.solheim/refid4 2009-08-14T11:54:31Z

BACKGROUND: New methods have been used, with promising results, to treat full-thickness cartilage defects. The objective of the present study was to compare autologous chondrocyte implantation with microfracture in a randomized trial. We are not aware of any previous randomized studies comparing these methods. METHODS: Eighty patients without general osteoarthritis who had a single symptomatic car...<br/><br/>Gunnar Knutsen, Lars Engebretsen, Tom C Ludvigsen, Jon Olav Drogset, Torbjørn Grøntvedt, Eirik Solheim, Torbjørn Strand, Sally Roberts, Vidar Isaksen, Oddmund Johansen (2004) <i>J Bone Joint Surg Am</i> <i></i> <i></i> 86-A: 3 455-464<br/>

http://publicationslist.org/eirik.solheim/refid5 2009-08-14T11:54:31Z

PURPOSE: Focal chondral or osteochondral defects can be painful and disabling, have a poor capacity for repair, and may predispose patients for osteoarthritis. New surgical procedures that aim to reestablish hyaline cartilage have been introduced and the results seem promising. The purpose of this study is to provide reliable data on chondral and osteochondral defects in patients with symptomatic ...<br/><br/>Karin Hjelle, Eirik Solheim, Torbjørn Strand, Rune Muri, Mats Brittberg (2002) <i>Arthroscopy</i> <i></i> <i></i> 18: 7 730-734<br/>

http://publicationslist.org/eirik.solheim/refid6 2009-08-14T11:54:31Z

Revascularisation of bone grafts is influenced by both the anatomical origin and the pre-implantation processing of the graft. We investigated the revascularisation by entrapment of 141Ce (cerium)-labelled microspheres in large, fresh and demineralised syngeneic grafts of predominantly cancellous (iliac bone) or cortical (tibial diaphysis) bone three weeks after heterotopic implantation in rats. T...<br/><br/>E Solheim, E M Pinholt, O Talsnes, T B Larsen, O J Kirkeby (2001) <i>Scand J Plast Reconstr Surg Hand Surg</i> <i></i> <i></i> 35: 2 113-116<br/>

http://publicationslist.org/eirik.solheim/refid7 2009-08-14T11:54:31Z

Bone formation generally depends on adequate blood flow. Failure of bone grafts has been attributed to delayed revascularisation of the graft. We compared the relationship between revascularisation and osteogenesis, evaluated as entrapment of (141)Ce-labelled microspheres and uptake of (85)Sr, respectively, in fresh or demineralised syngeneic bone grafts 3 weeks after heterotopic implantation in r...<br/><br/>E Solheim, E M Pinholt, O Talsnes, T B Larsen, O J Kirkeby (2001) <i>Eur Surg Res</i> <i></i> <i></i> 33: 1 42-46<br/>

http://publicationslist.org/eirik.solheim/refid9 2009-08-14T11:54:31Z

Implantation of demineralized bone induces new bone formation by the action of contained growth factors, of which bone morphogenetic proteins are of prime importance. A biodegradable polymer may be used as a carrier for demineralized bone particles or recombinant bone growth factors to prevent displacement of the implant, preserve its volume and shape, and assure sustained release of the incorpora...<br/><br/>E Solheim, B Sudmann, G Bang, E Sudmann (2000) <i>J Biomed Mater Res</i> <i></i> <i></i> 49: 2 257-263<br/>

http://publicationslist.org/eirik.solheim/refid8 2009-08-14T11:54:31Z

Articular cartilage has little ability to regenerate. Cartilage lesions usually persist, may provoke pain, swelling, locking and disability, and may predispose for development of osteoarthritis. Long-term results after traditional surgical techniques are unsatisfactory. In recent years, auto-transplantation of chondrocytes and osteochondral cylinder grafts aimed at reconstituting the chondral surf...<br/><br/>E Solheim (1999) <i>Tidsskr Nor Laegeforen</i> <i></i> <i></i> 119: 27 4022-4025<br/>

http://publicationslist.org/eirik.solheim/refid13 2009-08-14T11:55:20Z

Demineralized allogenic bone implanted in the subcutis or muscle of rodents causes formation of heterotopic bone by osteoinduction. The osteoinductive response may be weaker in primates than in rodents. It was suggested that the osteoinductive response of demineralized bone for clinical use could be enhanced by using young donors, because studies have indicated that the osteoinductive response is ...<br/><br/>E M Pinholt, E Solheim (1998) <i>J Craniofac Surg</i> <i></i> <i></i> 9: 2 142-146<br/>

http://publicationslist.org/eirik.solheim/refid11 2009-08-14T11:55:20Z

Bone contains several growth factors, including bone morphogenetic proteins (BMPs), transforming growth factor beta (TGF-beta), insulin-like growth factors I and II (IGF-I and IGF-II), platelet derived growth factor (PDGF) and basic and acidic fibroblast growth factor (bFGF and aFGF). The BMPs are the only factors known to provoke bone formation heterotopically by making undifferentiated mesenchym...<br/><br/>E Solheim (1998) <i>Int Orthop</i> <i></i> <i></i> 22: 5 335-342<br/>

http://publicationslist.org/eirik.solheim/refid12 2009-08-14T11:55:20Z

Chondrocytes in adult human cartilage have little mitotic capacity even after injuries. Deep injuries penetrating the subchondral bone plate lead to the release of pluripotent mesenchymal stem cells which have the potential to differentiate into different types of connective tissue, including bone and cartilage. The release and stimulation of these stem cells can also be achieved by drilling or mi...<br/><br/>G Knutsen, E Solheim, O Johansen (1998) <i>Tidsskr Nor Laegeforen</i> <i></i> <i></i> 118: 16 2493-2497<br/>

http://publicationslist.org/eirik.solheim/refid10 2009-08-14T11:55:20Z

Bone contains several growth factors, including bone morphogenetic proteins (BMPs), transforming growth factor beta (TGF-beta), insulin-like growth factors I and II (IGF-I and IGF-II), platelet derived growth factor (PDGF) and basic and acidic fibroblast growth factor (bFGF and aFGF). Spatial and temporal variations in the expression and secretion of the various growth factors have been demonstrat...<br/><br/>E Solheim (1998) <i>Int Orthop</i> <i></i> <i></i> 22: 6 410-416<br/>

http://publicationslist.org/eirik.solheim/refid17 2009-08-14T11:55:20Z

BACKGROUND AND AIMS: Our knowledge on how often tears of the anterior cruciate ligament (ACL) initially remain undetected and the outcome of the resulting non-operative regimen is still incomplete. To investigate these issues, we conducted a follow-up study in young individuals that 4 to 5 years earlier had sustained a knee injury during a sports event that had been diagnosed as a first-degree spr...<br/><br/>T Strand, F K Sørensen, E Solheim (1997) <i>Ann Chir Gynaecol</i> <i></i> <i></i> 86: 3 244-247<br/>

http://publicationslist.org/eirik.solheim/refid16 2009-08-14T11:55:20Z

We have used open reduction and internal fixation with a T-plate in 31 displaced, intraarticular fractures of the distal radius which were judged irreducible or in which closed reduction failed. The mean follow-up time was 4 (3-7) years. The dorsal angulation, the radial length, the articular step-off and the intraarticular gap between fragments were substantially improved after surgery. 30 patien...<br/><br/>L M Hove, P T Nilsen, O Furnes, H E Oulie, E Solheim, A O Mölster (1997) <i>Acta Orthop Scand</i> <i></i> <i></i> 68: 1 59-63<br/>

http://publicationslist.org/eirik.solheim/refid15 2009-08-14T11:55:20Z

The anatomical and functional outcome and complications after closed reduction and external fixation of unstable fractures of the distal radius were reviewed in 29 patients. The fractures were reduced by longitudinal traction and closed manipulation under fluoroscopic control, and the reduced position was retained by a standard half-frame Hoffmann external fixator for six to eight weeks. The mean ...<br/><br/>L M Hove, O Furnes, P T Nilsen, H E Oulie, E Solheim, A O Mölster (1997) <i>Scand J Plast Reconstr Surg Hand Surg</i> <i></i> <i></i> 31: 2 159-164<br/>

http://publicationslist.org/eirik.solheim/refid14 2009-08-14T11:55:20Z

All cruciate ligament injuries in the three upper divisions for men and women (3392 players) in Norwegian team handball in the 1989-90 and 1990-91 seasons were registered. A questionnaire was mailed to all injured players. Ninety-three cruciate ligament injuries were registered; 87 in the anterior cruciate ligament (ACL), and six in the posterior cruciate ligament (PCL). Among women, 1.8% were inj...<br/><br/>G Myklebust, S Maehlum, L Engebretsen, T Strand, E Solheim (1997) <i>Scand J Med Sci Sports</i> <i></i> <i></i> 7: 5 289-292<br/>

http://publicationslist.org/eirik.solheim/refid19 2009-08-14T11:56:09Z

Fifty open tibial fractures were treated with the Ex-fi-re external fixation system from 1987 to 1994. According to the Gustilo and Anderson classification, there were 12 Grade I, 14 Grade II, 10 Grade IIIA, 13 Grade IIIB, and 1 Grade IIIC injuries. Eight fractures were segmental. The average patient patient age was 39 years (range, 16-85 years). With the reduction unit of the system, displaced ti...<br/><br/>P Helland, A Bøe, A O Mølster, E Solheim, M Hordvik (1996) <i>Clin Orthop Relat Res</i> <i></i> <i></i> : 326 209-220<br/>

http://publicationslist.org/eirik.solheim/refid18 2009-08-14T11:55:20Z

Thirty 8-week-old male Wistar rats were randomly allocated into three groups of 10 rats each. A 5-mm defect in the left parietal bone was made in each rat. In the defects of the first group of rats, no implant was used (control group). In the second group, polyorthoester membranes were placed in the defects without active substance. In the third group, polyorthoester membranes were placed with ins...<br/><br/>O Busch, E Solheim, G Bang, K Tornes (1996) <i>Int J Oral Maxillofac Implants</i> <i></i> <i></i> 11: 4 498-505<br/>

http://publicationslist.org/eirik.solheim/refid21 2009-08-14T11:56:09Z

Inhibition of orthotopic reossification after surgical removal of bone is sometimes indicated and may be accomplished by implantation of interpositional materials or by systemic administration of indomethacin. However, implantation of nonresorbable foreign material may induce a chronic inflammation and predispose to infections; and systemic administration of indomethacin may induce systemic advers...<br/><br/>E Solheim, E M Pinholt, R Andersen, G Bang, E Sudmann (1995) <i>J Biomed Mater Res</i> <i></i> <i></i> 29: 9 1141-1146<br/>

http://publicationslist.org/eirik.solheim/refid24 2009-08-14T11:56:09Z

Forty-two patients referred to the outpatient clinic of Hagavik Orthopaedic Hospital within 3 weeks after an acute knee injury was found by arthroscopy to have a partial or total tear of the anterior cruciate ligament (ACL). In these patients, the results of clinical tests and instrumented laxity tests without anesthesia prior to the arthroscopy were analyzed. The Lachman test and the maximum ante...<br/><br/>T Strand, E Solheim (1995) <i>Int J Sports Med</i> <i></i> <i></i> 16: 1 51-53<br/>

http://publicationslist.org/eirik.solheim/refid22 2009-08-14T11:56:09Z

It has been shown that different sterilization procedures of demineralized bone may influence its osteoinductive properties. The aim of this study was to evaluate the effect of ethylene oxide sterilization for 1, 3, and 6 hours on the osteoinductive potential of allogeneic demineralized bone implanted heterotopically in rats. Sixty male Wistar rats were randomly assigned to one of four groups, A t...<br/><br/>E Solheim, E M Pinholt, G Bang, E Sudmann (1995) <i>J Craniofac Surg</i> <i></i> <i></i> 6: 3 195-198<br/>

http://publicationslist.org/eirik.solheim/refid23 2009-08-14T11:56:09Z

Several studies have suggested that grafts from membranous derived bone (e.g., calvarial grafts) retain their volume better than those from endochondral derived bone (e.g., iliac bone grafts). Increased osteogenesis in grafts of the former type has been offered as the explanation. However, simple volume measurements of the recovered grafts do not differentiate between viable and dead bone. We stud...<br/><br/>E Solheim, E M Pinholt, O Talsnes, T B Larsen, O J Kirkeby (1995) <i>J Craniofac Surg</i> <i></i> <i></i> 6: 2 139-142<br/>

http://publicationslist.org/eirik.solheim/refid20 2009-08-14T11:56:09Z

During 1988 we recorded all Colles' fractures (n = 530) in a prospective study in the city of Bergen. According to defined criteria, the fractures were treated by immobilisation in plaster cast with or without reduction; reduction and immobilisation by a Hoffman external fixation device; or open reduction and internal fixation. Included in the present study were 26 patients with secondary displace...<br/><br/>L M Hove, K Fjeldsgaard, R Skjeie, E Solheim (1995) <i>Scand J Plast Reconstr Surg Hand Surg</i> <i></i> <i></i> 29: 4 349-355<br/>

http://publicationslist.org/eirik.solheim/refid26 2009-08-14T11:57:06Z

A requirement for the clinical use of demineralized bone is the possibility of storing the material without loss of its osteoinductive properties. Seventy-five 8-week-old male Wistar rats were randomly assigned to one of five groups of 15 rats each. Lyophilized demineralized allogeneic bone was prepared and implanted in the abdominal muscle either without prior storage (control group) or after sto...<br/><br/>E M Pinholt, E Solheim (1994) <i>Ann Plast Surg</i> <i></i> <i></i> 33: 5 531-535<br/>

http://publicationslist.org/eirik.solheim/refid25 2009-08-14T11:56:09Z

In a prospective study, 645 consecutive Colles' fractures treated conservatively were followed until union. The fractures subsequently lost some of their manipulated position during the immobilization period. However, the anatomical end result was significantly improved compared with the initial deformity. The mean shortening of the radius during plaster-cast treatment was 3 mm, and the mean incre...<br/><br/>L M Hove, E Solheim, R Skjeie, F K Sörensen (1994) <i>J Hand Surg Br</i> <i></i> <i></i> 19: 6 731-736<br/>

http://publicationslist.org/eirik.solheim/refid27 2009-08-14T11:57:06Z

Some studies have suggested that membranous bone grafts undergo less resorption than endochondral grafts, and faster revascularization of the former has been proposed as the explanation. We studied fresh syngeneic full-thickness bone grafts from calvaria, mandibula, tibia diaphysis, and iliac bone implanted in the back muscles of young Lewis rats. As a measure of the quantity of cancellous bone in...<br/><br/>E M Pinholt, E Solheim, O Talsnes, T B Larsen, G Bang, O J Kirkeby (1994) <i>Ann Plast Surg</i> <i></i> <i></i> 33: 2 193-197<br/>

http://publicationslist.org/eirik.solheim/refid28 2009-08-14T11:57:06Z

Anterior cruciate ligament reconstruction by free patellar tendon graft was performed using 2 different surgical approaches to the intercondylar notch in 67 consecutive patients with chronic anterior cruciate ligament insufficiency. In the first 30 patients (Group A), the traditional medial parapatellar arthrotomy with lateral luxation of the patella was done, whereas in the last 37 patients (Grou...<br/><br/>E Solheim, T Strand (1993) <i>Am J Sports Med</i> <i></i> <i></i> 21: 4 507-509<br/>

http://publicationslist.org/eirik.solheim/refid41 2011-06-11T15:48:29Z

Three different membranes were tested for guided bone regeneration in 8-mm unicortical trephine defects in rabbit tibia. All experimental and control defects healed with bone. The critical size defect in rabbit tibia is larger than 8 mm, because control defects, 8 mm in diameter, healed spontaneously. Around remnants of the biodegradable Polyglactin 910 mesh (Vicryl@), a diffuse infiltration of in...<br/><br/>M Aaboe, EM Pinholt, E Hjørting-Hansen, E Solheim, F Prætorius (1993) <i>Clin Oral Impl Res</i> 4: 172-176<br/>

http://publicationslist.org/eirik.solheim/refid33 2009-08-14T11:57:56Z

A study was done to evaluate the effect of a system for the local delivery of indomethacin on demineralized bone-induced formation of heterotopic bone in the abdominal muscles of rats. Two separate investigations were conducted on a total of forty-eight Wistar rats. In both series, two types of implants were used: polyorthoester and demineralized bone (Group A, the control group) and polyorthoeste...<br/><br/>E Solheim, E M Pinholt, G Bang, E Sudmann (1992) <i>J Bone Joint Surg Am</i> <i></i> <i></i> 74: 5 705-712<br/>

http://publicationslist.org/eirik.solheim/refid34 2009-08-14T11:57:56Z

A study was performed to evaluate regeneration of defects in rat calvaria either unfilled or filled with a bioerodible polyorthoester only, demineralized bone only, or a composite of both. At 4 weeks, histological and radiographic studies showed that defects filled with a composite of bioerodible polyorthoester and demineralized bone or demineralized bone alone were bridged by bone. Unfilled defec...<br/><br/>E Solheim, E M Pinholt, G Bang, E Sudmann (1992) <i>J Neurosurg</i> <i></i> <i></i> 76: 2 275-279<br/>

http://publicationslist.org/eirik.solheim/refid32 2009-08-14T11:57:06Z

Local hemostatics for osseous tissue should preferably be absorbable and biocompatible and should not inhibit osteogenesis. The tissue response and effect on demineralized bone-induced heterotopic osteogenesis in the abdominal muscle of 120 male Wistar rats by different local hemostatics were evaluated by light microscopy and 85Sr uptake analyses. Non-absorbable bone wax of 88% beeswax and absorba...<br/><br/>E Solheim, E M Pinholt, G Bang, E Sudmann (1992) <i>J Biomed Mater Res</i> <i></i> <i></i> 26: 6 791-800<br/>

http://publicationslist.org/eirik.solheim/refid31 2009-08-14T11:57:06Z

Heterotopic bone formation in the abdominal muscle of 45 male 8-week-old Wistar rats induced by implantation of 5, 10, or 15 mg demineralized bone (DBM) powder was evaluated at 4 weeks by 85Sr uptake of the implants and area histomorphometry of the induced bone. Two indices of 85Sr uptake were calculated: the osteogenic index [(counts/min/mg implant)/(counts/min/mg os ilium)] and an index that we ...<br/><br/>E Solheim, E M Pinholt, G Bang, E Sudmann (1992) <i>Acta Orthop Scand</i> <i></i> <i></i> 63: 3 334-338<br/>

http://publicationslist.org/eirik.solheim/refid29 2009-08-14T11:57:06Z

The effect of a composite of demineralized bone mixed with polyorthoester on the healing of large segmental defects in the rat radius was studied. Sixty male Wistar rats were divided into four groups, A through D, and an osteoperiosteal diaphyseal defect of 50 per cent of the length of the bone was made in the right radius of each rat. In Group A, the defect was filled with polyorthoester and demi...<br/><br/>E Solheim, E M Pinholt, R Andersen, G Bang, E Sudmann (1992) <i>J Bone Joint Surg Am</i> <i></i> <i></i> 74: 10 1456-1463<br/>

http://publicationslist.org/eirik.solheim/refid30 2009-08-14T11:57:06Z

Host tissue response and heterotopic osteoinduction by composites of demineralized bone matrix and three different substances used as bioresorbable carriers implanted in the abdominal muscles were evaluated by strontium 85 uptake and histology 4 weeks postoperatively in 60 male Wistar rats. Both fibrin-collagen paste and fibrin sealant inhibited bone induction and produced a chronic inflammation; ...<br/><br/>E M Pinholt, E Solheim, G Bang, E Sudmann (1992) <i>J Oral Maxillofac Surg</i> <i></i> <i></i> 50: 12 1300-1304<br/>

http://publicationslist.org/eirik.solheim/refid36 2009-08-14T11:57:56Z

The platelets play an important role in the normal hemostasis, and it is known that both natural and synthetic macromolecules may induce platelet activation and aggregation. Thus, the purpose of the present study was to investigate the platelet aggregating effect of five different local hemostatics. Platelet aggregation was assessed by aggregometry. Unwoven fleece of bovine collagen polymer in fib...<br/><br/>E Solheim, O G Anfinsen, H Holmsen, E Sudmann (1991) <i>Eur Surg Res</i> <i></i> <i></i> 23: 1 45-50<br/>

http://publicationslist.org/eirik.solheim/refid35 2009-08-14T11:57:56Z

A composite of a local, sustained, drug-release system, Alzamer bioerodible polyorthoester, and demineralized bone-matrix (DBM) particles implanted in the abdominal muscle of 89 Wistar rats induced cartilage and bone formation at the same rate as DBM when evaluated histologically and by 85Sr uptake. The composite implant was technically easier to use than DBM alone.<br/><br/>E M Pinholt, E Solheim, G Bang, E Sudmann (1991) <i>Acta Orthop Scand</i> <i></i> <i></i> 62: 5 476-480<br/>