http://publicationslist.org/data/enrico.scala/atom.xml Enrico Scalahttp://publicationslist.org/enrico.scala$basepathfavicon.icoRecent additions to Enrico Scala's PublicationsList.org pagehttp://publicationslist.org/publications.png2008-06-23T20:42:28Z http://publicationslist.org/enrico.scala/refid1 2008-06-23T20:40:16Z

Kiwellin, an allergenic protein formerly isolated from green kiwi fruit, has been identified as the most abundant component of the gold kiwi species. A protein named KiTH, showing a 20 kDa band on reducing SDS-PAGE and 100% identity with the C-terminal region of kiwellin, has been identified in the extract of the ripe green species. In vitro treatment of purified kiwellin with the protease actinid...<br/><br/>Lisa Tuppo, Ivana Giangrieco, Paola Palazzo, Maria Livia Bernardi, Enrico Scala, Vito Carratore, Maurizio Tamburrini, Adriano Mari, M Antonietta Ciardiello (2008) <i>J Agric Food Chem</i> <i></i> <i></i> 56: 10 3812-3817<br/>

http://publicationslist.org/enrico.scala/refid2 2008-06-23T20:40:16Z

The diagnosis and therapy of allergic disorders are usually performed with crude extracts which are a heterogeneous mixture of proteins with different allergenic potency. The knowledge of the allergenic composition is a key step for diagnostic and therapeutic options. Parietaria judaica pollen represents one of the main sources of allergens in the Mediterranean area and its major allergens have al...<br/><br/>A Bonura, L Gulino, A Trapani, G Di Felice, R Tinghino, S Amoroso, D Geraci, R Valenta, K Westritschnig, E Scala, A Mari, P Colombo (2008) <i>Mol Immunol</i> <i></i> <i></i> 45: 9 2465-2473<br/>

http://publicationslist.org/enrico.scala/refid6 2008-06-23T20:40:16Z

BACKGROUND: Immunoglobluin E (IgE)-mediated hypersensitivity to natural rubber latex (NRL) is a major problem in allergy practice. Currently, the use of skin prick tests (SPTs) with latex extracts and specific IgE detection for the diagnosis of NRL allergy in suspected patients is directed to identification of risk factors. Many cases of NRL allergy remain undiagnosed due to misreporting of sympto...<br/><br/>Adriano Mari, Enrico Scala, Claudio D'Ambrosio, Heimo Breiteneder, Stefan Wagner (2007) <i>Int Arch Allergy Immunol</i> <i></i> <i></i> 143: 2 135-143<br/>

http://publicationslist.org/enrico.scala/refid5 2008-06-23T20:40:16Z

This study was aimed at showing the capacity of probiotic VSL#3 to hydrolyze wheat flour allergens. Hydrolysis was investigated either by the use of baker's yeast bread treated with digestive enzymes and VSL#3, an experimental design that mimicked the activity of probiotics during gut colonization, or by the use of VSL#3 as a starter for dough fermentation, an experimental design that mimicked the...<br/><br/>Maria De Angelis, Carlo G Rizzello, Enrico Scala, Claudio De Simone, Giovanni A Farris, Francesco Turrini, Marco Gobbetti (2007) <i>J Food Prot</i> <i></i> <i></i> 70: 1 135-144<br/>

http://publicationslist.org/enrico.scala/refid8 2008-06-23T20:40:16Z

BACKGROUND: Muscle relaxants represent the drugs most frequently involved in intraoperative anaphylaxis during surgical procedures. Our aim was to report the case of a delayed reaction to suxamethonium and analyze specific T cell lines with regard to their specificity, phenotype and cytokine profile. METHODS: We generated a drug-specific T cell line from a biopsy at the site of positive intraderma...<br/><br/>Enrico Scala, Emma C Guerra, Mauro Giani, Lia Pirrotta, Maria Locanto, Chiara Mondino, Adriano Mari (2006) <i>Int Arch Allergy Immunol</i> <i></i> <i></i> 141: 1 24-30<br/>

http://publicationslist.org/enrico.scala/refid7 2008-06-23T20:40:16Z

Immunotherapy for allergic diseases give rise to questions about when a decision must be taken to define the number of extracts to be used in a single treatment. This represents a long-lasting matter of debate between American and European allergists, which seems to be without real solution. Through the use of extract-based versus molecule-based diagnostic approaches we suggest a possible solution...<br/><br/>Adriano Mari, Enrico Scala (2006) <i>Int Arch Allergy Immunol</i> <i></i> <i></i> 141: 1 57-60<br/>

http://publicationslist.org/enrico.scala/refid9 2008-06-23T20:40:16Z

Sézary syndrome (SS) is a rare form of cutaneous T-cell lymphoma (CTCL) characterized by a distinct metastatic pattern mainly involving blood and skin. Chemokines and their receptors play a critical role in cellular recruitment and homing to tissues and in the metastatic process of several tumors including non-Hodgkin T-cell lymphomas (NHLs). Here we report that SS cells express a functionally ac...<br/><br/>Maria Grazia Narducci, Enrico Scala, Antonella Bresin, Elisabetta Caprini, Maria Cristina Picchio, Daniele Remotti, Gianluca Ragone, Francesca Nasorri, Marina Frontani, Diego Arcelli, Stefano Volinia, Giuseppe Alfonso Lombardo, Giannandrea Baliva, Monica Napolitano, Giandomenico Russo (2006) <i>Blood</i> <i></i> <i></i> 107: 3 1108-1115<br/>

http://publicationslist.org/enrico.scala/refid3 2008-06-23T20:40:16Z

Allergens are proteins or glycoproteins that are recognized by IgE produced by the immune system of allergic individuals. Until now around 1,500 allergenic structures have been identified and this number seems not have reached a plateau after 3-4 decades of research and the advent of molecular biology. Several allergen databases are available on Internet. Different aims and philosophies lead to di...<br/><br/>Adriano Mari, Enrico Scala, Paola Palazzo, Stefano Ridolfi, Danila Zennaro, Gabriele Carabella (2006) <i>Cell Immunol</i> <i></i> <i></i> 244: 2 97-100<br/>

http://publicationslist.org/enrico.scala/refid4 2008-06-23T20:40:16Z

The approaches used in both basic research and clinical work in allergology must be reconsidered in the light of information technology. Internet resources are further amplified by the parallel development of other new tools, such as molecular biology and nanotechnology. Information technology, molecular biology and nanotechnology are tightly related entities that fully express their power once ap...<br/><br/>Adriano Mari, Enrico Scala (2006) <i>Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M</i> <i></i> <i></i> : 95 29-39; discussion 39-40<br/>

http://publicationslist.org/enrico.scala/refid11 2008-06-23T20:40:16Z

The Arg-Gly-Asp (RGD) motif is known to mediate cell adhesion to several extracellular matrix components as well as cell-cell interactions. In the present study, we investigated whether the RGDS peptide interferes with cell-cell recognition-based events such as allogeneic activation of PBMC and PBMC adhesion to human umbilical vein endothelial cells (HUVEC). We show here for the first time, to our...<br/><br/>Ubaldo Pozzetto, Maria Simona Aguzzi, Nicola Maggiano, Enrico Scala, Arnaldo Capelli, Marco Castagneto, Maurizio C Capogrossi, Franco Citterio, Francesco Serino, Antonio Facchiano (2005) <i>Immunol Cell Biol</i> <i></i> <i></i> 83: 1 25-32<br/>

http://publicationslist.org/enrico.scala/refid10 2008-06-23T20:40:16Z

We studied the expression of adhesion molecules affecting recirculation and homing on peripheral blood CD4(+) T cells of patients with systemic sclerosis (SSc), in order to evaluate whether the distribution of tissue targeted subsets could reflect the participation of internal organs or the extent of cutaneous involvement [i.e. limited cutaneous (lc) and diffuse cutaneous (dc)]. Peripheral blood m...<br/><br/>E Scala, R Paganelli, F Sampogna, D Abeni, L Colonna, O De Pità, P Puddu, G Russo (2005) <i>Clin Exp Immunol</i> <i></i> <i></i> 139: 3 551-557<br/>

http://publicationslist.org/enrico.scala/refid12 2008-06-23T20:40:16Z

Systemic sclerosis (SSc) is a connective tissue disorder characterized by excessive collagen deposition in the skin and internal organs. Several cytokines and chemokines have been implicated in the induction of fibrosis, but a definitive relationship between specific cytokines and organ involvement has not been established yet. Serum samples, PBMC and T cell lines (TCL) obtained from 54 patients a...<br/><br/>E Scala, S Pallotta, A Frezzolini, D Abeni, C Barbieri, F Sampogna, O De Pità, P Puddu, R Paganelli, G Russo (2004) <i>Clin Exp Immunol</i> <i></i> <i></i> 138: 3 540-546<br/>

http://publicationslist.org/enrico.scala/refid14 2008-06-23T20:40:16Z

E Scala, M Giani, L Pirrotta, C E Guerra, M Locanto, O De Pità, P Pietro (2003) <i>Allergy</i> <i></i> <i></i> 58: 2 160-161<br/>

http://publicationslist.org/enrico.scala/refid13 2008-06-23T20:40:16Z

BACKGROUND: Multiple drug allergy syndrome is a clinical condition characterized by reactions against more than one different class of, both pharmacologically and structurally, unrelated drugs. Scanty data are available to date about a multiple drug delayed hypersensitivity syndrome. Our aim was to report the case of a delayed reaction to both beta-methasone (beta-MT) and penicillin-G (pen-G) occu...<br/><br/>E Scala, M Giani, S Pastore, S Pallotta, E C Guerra, L Pirrotta, M L Locanto, A Frezzolini, O De Pità, P Puddu (2003) <i>Allergy</i> <i></i> <i></i> 58: 5 439-444<br/>

http://publicationslist.org/enrico.scala/refid18 2008-06-23T20:40:16Z

Enrico Scala, Maria Grazia Narducci, Paolo Amerio, Giannandrea Baliva, Romeo Simoni, Antonello Giovannetti, Lorena Silvestri, Pietro Puddu, Ornella De Pita, Giandomenico Russo (2002) <i>J Invest Dermatol</i> <i></i> <i></i> 119: 1 193-196<br/>

http://publicationslist.org/enrico.scala/refid17 2008-06-23T20:40:16Z

Proinflammatory cytokines are deemed to play a pivotal role in the pathogenesis of multiple sderosis (MS). They provide signals for T-cell activation and inflammatory cell recruitment in the brain and might directly alter neuroglial and neuronal cell survival and function. We found that peripheral blood mononuclear cells (PBMCs) from MS patents spontaneously produce high levels of TNFalpha, TNFbet...<br/><br/>F Ensoli, V Fiorelli, A Lugaresi, D Farina, M De Cristofaro, B Collacchi, D Santini Muratori, E Scala, M Di Gioacchino, R Paganelli, F Aiuti (2002) <i>Mult Scler</i> <i></i> <i></i> 8: 4 284-288<br/>

http://publicationslist.org/enrico.scala/refid16 2008-06-23T20:40:16Z

Ataxia telangiectasia (A-T), a genetic disorder caused by the homozygous mutation of the ATM gene, frequently associates with variable degrees of cellular and humoral immunodeficiency. However, the immune defects occurring in patients with A-T are still poorly characterized. Here we show that the T-cell receptor (TCR) variable beta (BV)-chain repertoire of 9 A-T patients was restricted by diffuse ...<br/><br/>Antonello Giovannetti, Francesca Mazzetta, Elisabetta Caprini, Alessandro Aiuti, Marco Marziali, Marina Pierdominici, Andrea Cossarizza, Luciana Chessa, Enrico Scala, Isabella Quinti, Giandomenico Russo, Massimo Fiorilli (2002) <i>Blood</i> <i></i> <i></i> 100: 12 4082-4089<br/>

http://publicationslist.org/enrico.scala/refid21 2008-06-23T20:40:16Z

E Scala, M Giani, L Pirrotta, E C Guerra, C R Girardelli, O De Pità, P Puddu (2001) <i>Allergy</i> <i></i> <i></i> 56: 5 454-455<br/>

http://publicationslist.org/enrico.scala/refid22 2008-06-23T20:40:16Z

E Scala, M Giani, L Pirrotta, E C Guerra, M Locanto, O De Pità, P Puddu (2001) <i>J Allergy Clin Immunol</i> <i></i> <i></i> 107: 3 <br/>

http://publicationslist.org/enrico.scala/refid20 2008-06-23T20:40:16Z

Anisakis simplex (AS), a fish and cephalopodes parasite, may cause allergic reactions in humans on eating and/or handling contaminated fish. We present a case of occupational hypersensitivity to AS in a woman employed in a frozen-fish factory. She showed both generalised urticarial rash and asthmatic symptoms after work place exposure. All these symptoms immediately disappeared after work place ex...<br/><br/>E Scala, M Giani, L Pirrotta, E C Guerra, S Cadoni, C R Girardelli, O De Pità, P Puddu (2001) <i>Eur J Dermatol</i> <i></i> <i></i> 11: 3 249-250<br/>

http://publicationslist.org/enrico.scala/refid15 2008-06-23T20:40:16Z

Metoclopramide hydrochloride (MCPH) is dopamine antagonist antiemetic drug that binds D2 receptor at the central nervous system and peripheral levels, which stimulates the upper gastrointestinal tract motility. It is often used in the management of some forms of nausea and vomiting (1-3). Occupational allergy to drugs is seldom reported. No case of occupational allergy to MCPH have been reported, ...<br/><br/> Scala, Giani, Pirrotta, Guerra, De Pità, Puddu (2001) <i>Int J Immunopathol Pharmacol</i> <i></i> <i></i> 14: 3 145-146<br/>

http://publicationslist.org/enrico.scala/refid19 2008-06-23T20:40:16Z

E Scala, M Giani, L Pirrotta, E C Guerra, O De Pità, P Puddu (2001) <i>Int J Dermatol</i> <i></i> <i></i> 40: 9 603-604<br/>

http://publicationslist.org/enrico.scala/refid23 2008-06-23T20:40:16Z

Chromosomal rearrangements observed in T-cell prolymphocytic leukemia involve the translocation of one T-cell receptor gene to either chromosome 14q32 or Xq28, deregulating the expression of cellular protooncogenes of unknown function, such as TCL1 or its homologue, MTCP1. In the human hematopoietic system, TCL1 expression is predominantly observed in developing B lymphocytes, whereas its overexpr...<br/><br/>M G Narducci, E Pescarmona, C Lazzeri, S Signoretti, A M Lavinia, D Remotti, E Scala, C D Baroni, A Stoppacciaro, C M Croce, G Russo (2000) <i>Cancer Res</i> <i></i> <i></i> 60: 8 2095-2100<br/>

http://publicationslist.org/enrico.scala/refid25 2008-06-23T20:40:16Z

Mycosis fungoides and Sézary syndrome represent the most frequent forms of cutaneous T cell lymphoma. Both are characterized by skin infiltrating and/or circulating malignant cells displaying a CD4+CD7- phenotype in the majority of cases. Because an expansion of CD4+CD7- cells may also be found in inflammatory dermatoses or in the aging process, we evaluated, by flow cytometry, the relationship b...<br/><br/>E Scala, G Russo, S Cadoni, M G Narducci, C R Girardelli, O De Pità, P Puddu (1999) <i>J Invest Dermatol</i> <i></i> <i></i> 113: 4 622-627<br/>

http://publicationslist.org/enrico.scala/refid26 2008-06-23T20:40:16Z

E Scala, E C Guerra, L Pirrotta, M Giani, O De Pità, P Puddu (1999) <i>Allergy</i> <i></i> <i></i> 54: 3 288-289<br/>

http://publicationslist.org/enrico.scala/refid24 2008-06-23T20:40:16Z

E Scala, M Giani, L Pirrotta, E C Guerra, O De Pità, P Puddu (1999) <i>Allergy</i> <i></i> <i></i> 54: 9 1008-1009<br/>

http://publicationslist.org/enrico.scala/refid29 2008-06-23T20:40:16Z

Evidence indicates that, at least in the early stage, Kaposi's sarcoma (KS) is a cytokine-mediated disease and that it is consistently associated with a novel herpesvirus termed human herpesvirus-8 (HHV-8). To gain insights into the mechanisms by which cytokines and HHV-8 may cooperate in disease pathogenesis, we examined the phenotype, the Th1 (gamma-interferon [gamma IFN]) and Th2 (interleukin-4...<br/><br/>M C Sirianni, L Vincenzi, V Fiorelli, S Topino, E Scala, S Uccini, A Angeloni, A Faggioni, D Cerimele, F Cottoni, F Aiuti, B Ensoli (1998) <i>Blood</i> <i></i> <i></i> 91: 3 968-976<br/>

http://publicationslist.org/enrico.scala/refid28 2008-06-23T20:40:16Z

R Paganelli, E Scala, F Aiuti, M Fiorilli (1998) <i>Immunol Today</i> <i></i> <i></i> 19: 3 <br/>

http://publicationslist.org/enrico.scala/refid27 2008-06-23T20:40:16Z

We evaluated the relationship between cytokine profile and the expression of the lymphocyte activation gene-3 (LAG-3) in both T cell clones and polyclonal T cell lines; LAG-3 is a CD4-like protein whose expression is reportedly restricted to Th1/0 cells and dependent upon IFN-gamma. We found that, while LAG-3 was expressed only by CD4+ T cell clones producing IFN-gamma, most CD8+ clones producing ...<br/><br/>E Scala, M Carbonari, P Del Porto, M Cibati, T Tedesco, A M Mazzone, R Paganelli, M Fiorilli (1998) <i>J Immunol</i> <i></i> <i></i> 161: 1 489-493<br/>

http://publicationslist.org/enrico.scala/refid31 2008-06-23T20:40:16Z

The authors studied CD40 ligant (CD40L) expression and interleukin-10 (IL-10) production in 16 patients with common variable immunodeficiency (CVI). Mean CD40L expression, determined by using cytofluorimetry, and measured as the mean fluorescence intensity following stimulation of peripheral blood mononuclear cells (PBMC) with phorbol myristate acetate (PMA) and calcium ionophore in 12 patients, w...<br/><br/>A Oliva, E Scala, I Quinti, R Paganelli, I J Ansotegui, A Giovannetti, M Pierdominici, F Aiuti, F Pandolfi (1997) <i>Scand J Immunol</i> <i></i> <i></i> 46: 1 86-90<br/>

http://publicationslist.org/enrico.scala/refid32 2008-06-23T20:40:16Z

A combination of three beta, or C-C, chemokines, as well as IL-16, have been shown to inhibit HIV replication in vitro. Cellular antiviral factor is a more potent agent, and acts on all HIV strains. All are mainly, but not exclusively, produced by CD8+ T cells, both in HIV+ and healthy subjects. We studied the production of these HIV-suppressive factors in patients with HIV infection at different ...<br/><br/>E Scala, G D'Offizi, R Rosso, O Turriziani, R Ferrara, A M Mazzone, G Antonelli, F Aiuti, R Paganelli (1997) <i>J Immunol</i> <i></i> <i></i> 158: 9 4485-4492<br/>

http://publicationslist.org/enrico.scala/refid30 2008-06-23T20:40:16Z

M C Sirianni, L Vincenzi, S Topino, E Scala, A Angeloni, R Gonnella, S Uccini, A Faggioni (1997) <i>J Infect Dis</i> <i></i> <i></i> 176: 2 <br/>

http://publicationslist.org/enrico.scala/refid33 2008-06-23T20:40:16Z

R Paganelli, E Scala, A M Mazzone, R Rosso, G Mattiacci, L Dell'Anna, I Mezzaroma, F Aiuti (1997) <i>Allergy</i> <i></i> <i></i> 52: 1 110-111<br/>

http://publicationslist.org/enrico.scala/refid38 2008-06-23T20:40:16Z

E Guerra, G Ricci, M Carlesimo, A R Varani, O Pontesilli, E Scala, I Mezzaroma, Pierdominici, F Pandolfi, A Antinori, A De Luca, R Murri, A Ammassari, L Ortona, F Aiuti (1996) <i>Antibiot Chemother</i> <i></i> <i></i> 48: 147-154<br/>

http://publicationslist.org/enrico.scala/refid36 2008-06-23T20:40:16Z

Centenarians, particularly healthy centenarians, constitute the example of successful aging and the study of their immune status can help to define the endpoint of the changes occurring throughout life. We characterized T cell clones (TCC) of two healthy centenarians, studying their phenotypes and production of representative Th1 and Th2 cytokines (IFN-gamma and IL-4) and compared them with TCC ob...<br/><br/>R Paganelli, E Scala, R Rosso, A Cossarizza, L Bertollo, D Barbieri, A Fabrizi, E A Lusi, U Fagiolo, C Franceschi (1996) <i>Eur J Immunol</i> <i></i> <i></i> 26: 9 2030-2034<br/>

http://publicationslist.org/enrico.scala/refid37 2008-06-23T20:40:16Z

R Paganelli, E Scala, M Di Gioacchino, B Bellioni, G F Stefanini (1996) <i>Monogr Allergy</i> <i></i> <i></i> 32: 246-252<br/>

http://publicationslist.org/enrico.scala/refid35 2008-06-23T20:40:16Z

S Bellegrandi, G D'Offizi, I J Ansotegui, R Ferrara, E Scala, R Paganelli (1996) <i>J Am Acad Dermatol</i> <i></i> <i></i> 35: 4 <br/>

http://publicationslist.org/enrico.scala/refid34 2008-06-23T20:40:16Z

The association between an acquired form of hyper-IgM syndrome and a chronic hepatitis C virus (HCV) infection in a 71-year-old female patient is described. Both diseases were diagnosed at the age of 58 years. She was started on intramuscular and then intravenous immunoglobulin replacement therapy. HCV RNA was detected in 1992. The patient remained in well-balanced clinical condition until 1994, w...<br/><br/>I Quinti, A Giovannetti, R Paganelli, L P Pucillo, A R Varani, G Ricci, E Scala, F Pandolfi, M Casato, F Aiuti (1996) <i>J Clin Immunol</i> <i></i> <i></i> 16: 6 321-325<br/>

http://publicationslist.org/enrico.scala/refid43 2008-06-23T20:40:16Z

In this study we describe a series of nine patients affected by acquired immunodeficiency syndrome (AIDS) or AIDS-related complex who had hypereosinophilia and hyperimmunoglobulinemia E (hyper-IgE) with chronic dermatitis and recurrent staphylococcal infections. These patients had features similar to those present in hyper-IgE syndrome, a primary immunodeficiency disease. In addition, immunologic ...<br/><br/>R Paganelli, E Scala, I Mezzaroma, E Pinter, G D'Offizi, E Fanales-Belasio, R M Rosso, I J Ansotegui, F Pandolfi, F Aiuti (1995) <i>J Allergy Clin Immunol</i> <i></i> <i></i> 95: 5 Pt 1 995-1003<br/>

http://publicationslist.org/enrico.scala/refid44 2008-06-23T20:40:16Z

PURPOSE: To determine the efficacy of percutaneous needle aspiration (PNA) with antibiotic therapy in treatment for pyogenic liver abscess (PLA). MATERIALS AND METHODS: One hundred fifteen patients (59 male; 56 female; age range, 16-86 years; mean age, 45.3 years) with 147 PLAs (mean diameter, 6.8 cm; range, 3-16 cm) underwent PNA with ultrasound (US) guidance and antibiotic therapy. Needle calibe...<br/><br/>A Giorgio, L Tarantino, N Mariniello, G Francica, E Scala, P Amoroso, A Nuzzo, G Rizzatto (1995) <i>Radiology</i> <i></i> <i></i> 195: 1 122-124<br/>

http://publicationslist.org/enrico.scala/refid45 2008-06-23T20:40:16Z

Increased levels of serum IgE and eosinophilia have been described in human immunodeficiency virus (HIV) infection, almost exclusively in patients with CD4+ cell count < 200 cells/microliters. IgE production is regulated by CD4+ T helper type 2 (Th-2) lymphocytes, producing interleukin 4 (IL-4) and expressing a ligand for the B cell-specific CD40 molecule (CD40 ligand [L]). A shift to a Th-2-like ...<br/><br/>R Paganelli, E Scala, I J Ansotegui, C M Ausiello, E Halapi, E Fanales-Belasio, G D'Offizi, I Mezzaroma, F Pandolfi, M Fiorilli, A Cassone, F Aiuti (1995) <i>J Exp Med</i> <i></i> <i></i> 181: 1 423-428<br/>

http://publicationslist.org/enrico.scala/refid42 2008-06-23T20:40:16Z

E Scala, B Bellioni, E C Guerra, F Aiuti, R Paganelli (1995) <i>AIDS</i> <i></i> <i></i> 9: 6 653-654<br/>

http://publicationslist.org/enrico.scala/refid40 2008-06-23T20:40:16Z

Intranasal immunotherapy (IT) has been proposed as a means to induce an effective immunity of the nasal mucosa in patients with allergic rhinitis, avoiding systemic side effects. In the present study 20 individuals with chronic allergic rhinitis, and skin prick test reactive to Dermatophagoides pteronyssinus (DP) only, were randomized and subjected to a three months' double-blind placebo-controlle...<br/><br/>E Fanales-Belasio, A Ciofalo, G Zambetti, I J Ansotegui, E Scala, R Paganelli, F Filiaci (1995) <i>Rhinology</i> <i></i> <i></i> 33: 3 126-131<br/>

http://publicationslist.org/enrico.scala/refid41 2008-06-23T20:40:16Z

The immunologic defect in X-linked immunodeficiency and hyperimmunoglobulinemia M (HIM) are related to defective expression of the CD40 ligand (CD40L). We have studied two female patients with HIM to evaluate the role of CD40/CD40L in the pathogenesis of impaired immunoglobulin switching. In addition to recurrent infections characteristic of humoral immunodeficiencies, the two patients had chronic...<br/><br/>A Oliva, I Quinti, E Scala, E Fanales-Belasio, L Rainaldi, M Pierdominici, A Giovannetti, R Paganelli, F Aiuti, F Pandolfi (1995) <i>J Allergy Clin Immunol</i> <i></i> <i></i> 96: 3 403-410<br/>

http://publicationslist.org/enrico.scala/refid39 2008-06-23T20:40:16Z

CD8+CD45RA+ T lymphocytes present two distinct subpopulations expressing the CD11a molecule (LFA-1 alpha chain) with different intensity. CD11adim cells represent the unprimed population within the CD8+CD45RA+ subset, whereas CD11abright cells are activated and may be considered as memory lymphocytes. The aim of this study was to analyze the expression of CD11a and CD18 within the CD8+CD45RA+ popu...<br/><br/>E Scala, I J Ansotegui, B Bellioni, E C Guerra, F Aiuti, R Paganelli (1995) <i>AIDS Res Hum Retroviruses</i> <i></i> <i></i> 11: 11 1327-1333<br/>

http://publicationslist.org/enrico.scala/refid47 2008-06-23T20:40:16Z

We examined the expression of T cell markers in the peripheral blood of five immunologically normal human fetuses at 18-20 weeks of gestational age. The distribution of T cells expressing CD1, CD3, CD4, CD8, CD56, and the alpha/beta and gamma/delta receptors for antigen was comparable to that of newborns and normal adults, except for the absence of gamma/delta cells expressing the delta TCS-1 epit...<br/><br/>R Paganelli, M Cherchi, E Scala, E Maggi, M Carbonari, G Ferranti, L Dell'Anna, A Pachì, M Fiorilli (1994) <i>Cell Immunol</i> <i></i> <i></i> 155: 2 486-492<br/>

http://publicationslist.org/enrico.scala/refid46 2008-06-23T20:40:16Z

The interactions between B and T lymphocytes, leading to the development of humoral responses, are reviewed with references to the changes occurring in aged people. Aging is perceived as a process of impairment of immune functions; it is known that T cells from aged subjects have a reduced ability to produce IL-2. However, other functions seem to be upregulated in elderly subjects; indeed, IL-1, I...<br/><br/>R Paganelli, E Scala, I Quinti, I J Ansotegui (1994) <i>Aging (Milano)</i> <i></i> <i></i> 6: 3 143-150<br/>

http://publicationslist.org/enrico.scala/refid50 2008-06-23T20:40:16Z

R Paganelli, E Scala, I J Ansotegui, I Mezzaroma, E Pinter, R Ferrara, G P D'Offizi, F Aiuti (1993) <i>Immunodeficiency</i> <i></i> <i></i> 4: 1-4 149-152<br/>

http://publicationslist.org/enrico.scala/refid49 2008-06-23T20:40:16Z

We have determined the percentages and absolute numbers of lymphocyte subpopulations in 49 patients with common variable immunodeficiency (CVI). In vitro production of IL-6 by PHA-stimulated PBMC of 28 patients was also evaluated. Our data indicate profound alterations in the lymphocyte subpopulations evaluated, including increased CD8 cells (these cells outnumbered CD4 cells in 26 cases), severe ...<br/><br/>F Pandolfi, R Paganelli, A Cafaro, A Oliva, A Giovannetti, E Scala, I Quinti, F Aiuti (1993) <i>Immunodeficiency</i> <i></i> <i></i> 4: 1-4 19-23<br/>

http://publicationslist.org/enrico.scala/refid48 2008-06-23T20:40:16Z

The production of cytokines during aging, except interleukin (IL)-2, has been neglected in humans. We measured the in vitro production of IL-6, tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma and IL-1 beta by peripheral mononuclear cells from selected healthy young (mean age 26.8 years) and aged (mean age 80.2 years) subjects. Significant increases of IL-6, TNF-alpha and IL-1 beta levels...<br/><br/>U Fagiolo, A Cossarizza, E Scala, E Fanales-Belasio, C Ortolani, E Cozzi, D Monti, C Franceschi, R Paganelli (1993) <i>Eur J Immunol</i> <i></i> <i></i> 23: 9 2375-2378<br/>

http://publicationslist.org/enrico.scala/refid53 2008-06-23T20:40:16Z

Several immunological abnormalities have been observed in ataxia-telangiectasia (AT), the most consistent being defects of immunoglobulin isotypes, decreased T-cell numbers, and reduced proliferative responses to mitogens. We examined the distribution of T lymphocytes expressing distinctive surface Ag characteristic of "naive" (CD45RA+) and "memory" (CD29+, CD45RO+) T cells, in both CD4+ and CD8+ ...<br/><br/>R Paganelli, E Scala, E Scarselli, C Ortolani, A Cossarizza, D Carmini, F Aiuti, M Fiorilli (1992) <i>J Clin Immunol</i> <i></i> <i></i> 12: 2 84-91<br/>

http://publicationslist.org/enrico.scala/refid52 2008-06-23T20:40:16Z

We studied the clinical and immunological effects of three months' treatment with intranasal flunisolide (100 micrograms daily) in 18 allergic patients with perennial rhinitis. 17 were hypersensitive to house dust mite and one to Parietaria pollen only. We found no significant changes in white blood cell count, serum levels of IgE and nasal IgA. However the treatment induced a marked improvement o...<br/><br/>R Paganelli, I Quinti, A di Sabatino, G P d'Offizi, E Scala, P Meglio, F Aiuti (1992) <i>Allergol Immunopathol (Madr)</i> <i></i> <i></i> 20: 3 124-126<br/>

http://publicationslist.org/enrico.scala/refid51 2008-06-23T20:40:16Z

The study of 87 adults of different ages, including 15 centenarians, selected for their healthy status, showed that profound changes of humoral immunity occur throughout life. In particular, a statistically significant age-related increase of the serum level of immunoglobulin classes (IgG and IgA but not IgM) and IgG subclasses (IgG1, 2 and 3, but not IgG4) was detected. A parallel age-related dec...<br/><br/>R Paganelli, I Quinti, U Fagiolo, A Cossarizza, C Ortolani, E Guerra, P Sansoni, L P Pucillo, E Scala, E Cozzi (1992) <i>Clin Exp Immunol</i> <i></i> <i></i> 90: 2 351-354<br/>

http://publicationslist.org/enrico.scala/refid58 2008-06-23T20:40:16Z

We describe a new simplified solid phase immunoassay for the detection of anti-HIV antibodies. The results obtained analyzing a panel of sera from subjects showing a different pattern of reactivity on enzyme immunoassays and on Western blot demonstrated high sensitivity and specificity. The test does not require experienced laboratory staff nor the use of costly laboratory instruments.<br/><br/>I Quinti, E Guerra, I Mezzaroma, E Scala, L Rainaldi, C M Galluzzo, F Aiuti (1991) <i>Allergol Immunopathol (Madr)</i> <i></i> <i></i> 19: 1 15-18<br/>

http://publicationslist.org/enrico.scala/refid59 2008-06-23T20:40:16Z

Atopic dermatitis (AD) is a chronic inflammatory disease of the skin, frequently associated with a family history of atopy, raised serum IgE levels and other immunological abnormalities. Both eosinophils and their basic proteins have been detected in the skin lesions of AD patients. We measured the levels of eosinophil cationic protein (ECP) in sera of 24 children with AD and found them to be incr...<br/><br/>R Paganelli, E Fanales-Belasio, D Carmini, E Scala, P Meglio, L Businco, F Aiuti (1991) <i>Int Arch Allergy Appl Immunol</i> <i></i> <i></i> 96: 2 175-178<br/>

http://publicationslist.org/enrico.scala/refid57 2008-06-23T20:40:16Z

We evaluated the clinical response to oligoallergenic dietary treatment and the intestinal absorption of a protein antigen, cow milk beta-lactoglobulin (BLG) in 24 patients with chronic urticaria/angioedema syndrome 13 of whom also suffered from joint symptoms. Sixteen patients (77% of those with arthralgia) responded to diet (RD) with marked reduction of symptoms; the others did not respond (NR)....<br/><br/>R Paganelli, U Fagiolo, M Cancian, E Scala (1991) <i>Ann Allergy</i> <i></i> <i></i> 66: 2 181-184<br/>

http://publicationslist.org/enrico.scala/refid56 2008-06-23T20:40:16Z

We measured the in vitro production of interferon-gamma (IFN-gamma) in five cases of hyper-IgE syndrome (HIgE), induced by mitogens, calcium ionophores and phorbol ester. The biosynthesis of IFN-gamma was severely reduced or undetectable in HIgE, while it was near normal in most atopic patients. The in vitro spontaneous production of IgE was increased overall in HIgE patients, although no correlat...<br/><br/>R Paganelli, E Scala, M R Capobianchi, E Fanales-Belasio, G D'Offizi, M Fiorilli, F Aiuti (1991) <i>Clin Exp Immunol</i> <i></i> <i></i> 84: 1 28-33<br/>

http://publicationslist.org/enrico.scala/refid54 2008-06-23T20:40:16Z

R Paganelli, E Fanales-Belasio, E Scala, D Carmini, I Mezzaroma, E Pinter, F Aiuti (1991) <i>J Allergy Clin Immunol</i> <i></i> <i></i> 88: 3 Pt 1 416-418<br/>

http://publicationslist.org/enrico.scala/refid55 2008-06-23T20:40:16Z

We studied the clinical and immunological effects of three months' treatment with intranasal flunisolide (100 micrograms daily) in 18 allergic patients with perennial rhinitis. 17 were hypersensitive to house dust mite and one to Parietaria pollen only. We found no significant changes in white blood cell count, serum levels of IgE and nasal IgA. However the treatment induced a marked improvement o...<br/><br/>R Paganelli, I Quinti, A di Sabatino, G P d'Offizi, E Scala, P Meglio, F Aiuti (1991) <i>Allergol Immunopathol (Madr)</i> <i></i> <i></i> 19: 5 194-196<br/>

http://publicationslist.org/enrico.scala/refid61 2008-06-23T20:40:16Z

We studied 14 patients with irritable bowel syndrome for the presence of increased intestinal permeability to food antigens and their responses to diet with and without disodium cromoglycate. After a standardized oral challenge with cow milk, serum beta-lactoglobulin was increased above control values in three patients. This finding did not correlate with response to hypoallergenic diet or treatme...<br/><br/>R Paganelli, U Fagiolo, M Cancian, G C Sturniolo, E Scala, G P D'Offizi (1990) <i>Ann Allergy</i> <i></i> <i></i> 64: 4 377-380<br/>

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I Quinti, R Paganelli, E Scala, E Guerra, I Mezzaroma, G P D'Offizi, F Aiuti (1990) <i>Lancet</i> <i></i> <i></i> 336: 8727 <br/>

http://publicationslist.org/enrico.scala/refid63 2008-06-23T20:40:16Z

I Quinti, R Paganelli, E Scala, E Guerra, F Aiuti (1989) <i>Allergy</i> <i></i> <i></i> 44 Suppl 9: 59-64<br/>

http://publicationslist.org/enrico.scala/refid62 2008-06-23T20:40:16Z

E Scala, G Luzi, F Aiuti (1989) <i>Immunol Clin</i> <i></i> <i></i> 8: 4 201-213<br/>

http://publicationslist.org/enrico.scala/refid64 2008-06-23T20:40:16Z

R Paganelli, E Scala, E Guerra, I Quinti (1989) <i>Allergy</i> <i></i> <i></i> 44 Suppl 9: 65-69<br/>