http://publicationslist.org/data/esnault.v/atom.xml Vincent Esnaulthttp://publicationslist.org/esnault.v$basepathfavicon.icoRecent additions to Vincent Esnault's PublicationsList.org pagehttp://publicationslist.org/publications.png2010-09-13T15:49:36Z http://publicationslist.org/esnault.v/refid1 2010-09-13T15:48:41Z

BACKGROUND: Residual proteinuria is a strong modifiable risk factor for renal failure progression. We previously showed that the antiproteinuric effect of combined half doses of angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) is increased by raising diuretic dosage. Methods. We tested whether uptitration of loop diuretics on top of combined half doses of ACEI ...<br/><br/>Vincent L M Esnault, Amr Ekhlas, Jean-Michel Nguyen, Olivier Moranne (2010) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 25: 7 2218-2224<br/>

http://publicationslist.org/esnault.v/refid2 2010-09-13T15:48:41Z

BACKGROUND: Placebo-controlled trials have found that angiotensin-converting enzyme inhibitors (ACEIs) decrease proteinuria and slow the progression of nondiabetic nephropathies. However, head-to-head comparisons of ACEIs and calcium channel blockers (CCBs) have shown conflicting results. Indeed, a recent metaanalysis concluded that there is still uncertainty about the greater renoprotection seen ...<br/><br/>Vincent L M Esnault, Edwina A Brown, Eduard Apetrei, Jacques Bagon, Carlos Calvo, Rudolf DeChatel, Hallvard Holdaas, Silvester Krcmery, Zhanna Kobalava (2008) <i>Clin Ther</i> <i></i> <i></i> 30: 3 482-498<br/>

http://publicationslist.org/esnault.v/refid3 2010-09-13T15:48:41Z

AIMS: We tested whether bone scintigraphy could help in the etiological diagnosis in patients with mild rhabdomyolysis, because different patterns of soft tissue radiotracer uptake have been found on bone scintigraphy in patients presenting with severe rhabdomyolysis, with a localized asymmetric pattern in traumatic lesions and a more diffuse and symmetric pattern in nontraumatic lesions. However,...<br/><br/>Vincent L M Esnault, Magued Nakhla, Catherine Delcroix, Marie-Genevieve Moutel, Olivier Couturier (2007) <i>Clin Nucl Med</i> <i></i> <i></i> 32: 7 519-523<br/>

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Despite repeated campaigns promoting transplantation, the high donation refusal rate remains unchanged. We targeted a well-educated population to assess the impact of our current transplantation promoting programs and personal feelings toward new approaches to organ donation. A questionnaire was proposed in five universities to students and university staffs that would have been likely to benefit ...<br/><br/>Félix Cantarovich, Ricardo Heguilén, Mario Abbud Filho, Valter Duro-Garcia, Robert Fitzgerald, David Mayrhofer-Reinhartshuber, Maria-Luisa Lavitrano, Vincent L M Esnault (2007) <i>Transpl Int</i> <i></i> <i></i> 20: 6 512-518<br/>

http://publicationslist.org/esnault.v/refid5 2010-09-13T15:48:41Z

Crescentic glomerulonephritis are characterised by a crescent shaped cellular proliferation that may lead to glomerular destruction. Over 50% of at least 10 analysed glomeruli should be affected. The search for immune deposits by immunofluorescence is an important diagnostic step. Patients present with rapidly progressive glomerulonephritis (RPGN): renal failure, proteinuria and haematuria. Extra-...<br/><br/>Vincent Louis-Marie Esnault, Anne Moreau, Angelo Testa, Dominique Besnier (2006) <i>Nephrol Ther</i> <i></i> <i></i> 2: 7 446-460<br/>

http://publicationslist.org/esnault.v/refid6 2010-09-13T15:48:41Z

Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and diuretics may exert synergistic antiproteinuric effects. Eighteen patients with a proteinuria >1 g/24 h after 6 mo of treatment with ramipril at 5 mg/d were assigned to receive in random order ramipril at 10 mg/d, valsartan at 160 mg/d, or combined ramipril at 5 mg/d and valsartan at 80 mg/d in addition to their antihyper...<br/><br/>Vincent L M Esnault, Amr Ekhlas, Catherine Delcroix, Marie-Geneviève Moutel, Jean-Michel Nguyen (2005) <i>J Am Soc Nephrol</i> <i></i> <i></i> 16: 2 474-481<br/>

http://publicationslist.org/esnault.v/refid7 2010-09-13T15:48:41Z

BACKGROUND: The effect of furosemide on the survival and renal recovery of patients presenting with acute renal failure (ARF) is still debated. METHODS: Three hundred thirty-eight patients with ARF requiring dialysis therapy were randomly assigned to the administration of either furosemide (25 mg/kg/d intravenously or 35 mg/kg/d orally) or matched placebo, with stratification according to severity...<br/><br/>Félix Cantarovich, Badrudin Rangoonwala, Horst Lorenz, Matti Verho, Vincent L M Esnault (2004) <i>Am J Kidney Dis</i> <i></i> <i></i> 44: 3 402-409<br/>

http://publicationslist.org/esnault.v/refid9 2010-09-13T15:48:42Z

We tested whether rat and human MPO have similar antigenic determinants using 36 human MPO-ANCA positive sera, one mouse anti-rat MPO and four mouse anti-human MPO monoclonal reagents. Purified rat and human MPO were used in ELISA, with or without crossinhibition by preincubation with human MPO or irrelevant antigen in the liquid phase. Only one human MPO ANCA positive serum exhibited significant ...<br/><br/>Y C Patry, P H Nachman, M A P Audrain, R J Falk, K Meflah, V L M Esnault (2003) <i>Clin Exp Immunol</i> <i></i> <i></i> 132: 3 505-508<br/>

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Vincent L M Esnault (2003) <i>N Engl J Med</i> <i></i> <i></i> 349: 1 90-3; author reply 90-3<br/>

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Vincent L M Esnault (2002) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 17: 8 1362-1364<br/>

http://publicationslist.org/esnault.v/refid11 2010-09-13T15:48:42Z

Vincent L M Esnault (2002) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 17: 10 1725-1728<br/>

http://publicationslist.org/esnault.v/refid13 2010-09-13T15:48:42Z

BACKGROUND/PURPOSE: Extracorporeal photochemotherapy (ECP) has been proposed for the treatment of various auto- and allo-immune reactions. However, a standard ECP regimen did not significantly alter the course of chronic progressive multiple sclerosis (MS). We tested whether an intensive ECP treatment can affect the course of secondary chronic progressive form of MS. METHODS: Five patients free of...<br/><br/>D P Besnier, D Chabannes, J-M G Mussini, B Dupas, V L M Esnault (2002) <i>Photodermatol Photoimmunol Photomed</i> <i></i> <i></i> 18: 1 36-41<br/>

http://publicationslist.org/esnault.v/refid10 2010-09-13T15:48:42Z

BACKGROUND/PURPOSE: The mechanism responsible for the beneficial effects of extracorporeal photochemotherapy (ECP) remains unknown. In the rat model of experimental allergic encephalomyelitis (EAE), the transfer of encephalitogenic cells (EAE cells) induces transient passive EAE, followed by resistance to subsequent disease induction through immunization with central nervous system antigens (activ...<br/><br/>D Chabannes, D P Besnier, V L M Esnault (2002) <i>Photodermatol Photoimmunol Photomed</i> <i></i> <i></i> 18: 5 238-243<br/>

http://publicationslist.org/esnault.v/refid17 2010-09-13T15:48:42Z

Antineutrophil cytoplasmic antibodies (ANCA) are present in sera from patients with various forms of vasculitis-associated glomerulonephritis. Because autoantibodies may be directed against antigens presented by apoptotic cells, generation of ANCA using apoptotic neutrophils (PMN) in syngenic Brown Norway (BN) rats was attempted. These rats are T-helper type 2-prone animals, already used successfu...<br/><br/>Y C Patry, D C Trewick, M Gregoire, M A Audrain, A M Moreau, J Y Muller, K Meflah, V L Esnault (2001) <i>J Am Soc Nephrol</i> <i></i> <i></i> 12: 8 1764-1768<br/>

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BACKGROUND: ANCA are autoantibodies directed against polymorphonuclear cell antigens, mainly proteinase 3 (PR3) and myeloperoxidase (MPO), which are implicated in the pathogenesis of small-vessel necrotizing vasculitis. Alpha1-antitrypsin is the main inhibitor of neutral serine proteinase [i.e. human leukocyte elastase (HLE) and PR3] present in PMN alpha-granules (alphaGr). An association first re...<br/><br/>M A Audrain, R Sesboüé, T A Baranger, J Elliott, A Testa, J P Martin, C M Lockwood, V L Esnault (2001) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 16: 1 39-44<br/>

http://publicationslist.org/esnault.v/refid16 2010-09-13T15:48:42Z

V L Esnault (2001) <i>Presse Med</i> <i></i> <i></i> 30: 22 1119-1120<br/>

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DIAGNOSIS OF RENAL INVOLVEMENT: The diagnosis of renal involvement in patients with Wegener's disease and microscopic polyangeitis is facilitated with the search for antineutrophil cytoplasmic autoantibodies (ANCA) but still requires biopsy for confirmation. TWO THERAPEUTIC PHASES: Induction should be initiated immediately, and generally leads to initial remission. Long-term treatment is then need...<br/><br/>V L Esnault (2001) <i>Presse Med</i> <i></i> <i></i> 30: 22 1122-1125<br/>

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RENAL INVOLVEMENT: Several types of vascularides without antineutrophil cytoplasmic autoantibodies (ANCA) can affect the kidney. The most frequently encountered are small-vessel vascularides leading to glomerulonephritis: Goodpasture's disease, lupus, and, most importantly, rheumatoid purpura and type II mixed cryoglobulinemia secondary to hepatitis C. Medium-sized vessel vascularitis, such as occ...<br/><br/>V L Esnault (2001) <i>Presse Med</i> <i></i> <i></i> 30: 22 1126-1129<br/>

http://publicationslist.org/esnault.v/refid20 2010-09-13T15:48:42Z

V L Esnault (2000) <i>Nephron</i> <i></i> <i></i> 85: 2 183-184<br/>

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V L Esnault (2000) <i>Rev Prat</i> <i></i> <i></i> 50: 12 1383-1389<br/>

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Protein A immunoadsorption (IA) has proved effective in reducing proteinuria in patients with nephrotic syndrome after recurrence of focal and segmental glomerulosclerosis (FSGS) in kidney transplants. The effect of IA in nephrotic syndrome of other etiologies remains unknown. Nine patients with nephrotic syndrome secondary to membranous nephropathy (four cases), diabetes mellitus (one case), IgA ...<br/><br/>V L Esnault, D Besnier, A Testa, P Coville, P Simon, J F Subra, M A Audrain (1999) <i>J Am Soc Nephrol</i> <i></i> <i></i> 10: 9 2014-2017<br/>

http://publicationslist.org/esnault.v/refid23 2010-09-13T15:48:42Z

M A Audrain, D Reumaux, F Gerson, P Duthilleul, A Wiik, J Y Muller, V L Esnault (1999) <i>J Immunol Methods</i> <i></i> <i></i> 222: 1-2 219-220<br/>

http://publicationslist.org/esnault.v/refid21 2010-09-13T15:48:42Z

OBJECTIVES: Alpha1-antitrypsin (alpha1-AT) is encoded by a highly polymorphic gene with over 75 codominantly expressed alleles at the protease inhibitor (Pi) locus classified as normal, deficient, dysfunctional or null. The aim of this study was to determine in patients with inflammatory bowel disease: (i) the prevalence of anti-neutrophil cytoplasmic auto-antibodies (ANCA) and their antigen speci...<br/><br/>C Taddei, M A Audrain, D Reumaux, R Sesboüe, A Testa, J P Galmiche, P Duthilleul, J F Colombel, V L Esnault (1999) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 11: 11 1293-1298<br/>

http://publicationslist.org/esnault.v/refid26 2010-09-13T15:48:42Z

V L Esnault (1997) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 12: 2 249-251<br/>

http://publicationslist.org/esnault.v/refid25 2010-09-13T15:48:42Z

We studied the usefulness of monitoring antineutrophil cytoplasmic antibodies (ANCA) in chronic graft-versus-host disease (cGVHD), a major complication of allogeneic bone marrow transplantation. Antigen-specific ELISA and indirect immunofluorescence (IIF) were used to search for ANCA in 47 allogeneic bone marrow graft recipients who developed cGVHD and in 43 who did not (controls). Eight patients ...<br/><br/>S J Martin, M A Audrain, F Oksman, M Ecoiffier, M Attal, N Milpied, V L Esnault (1997) <i>Bone Marrow Transplant</i> <i></i> <i></i> 20: 1 45-48<br/>

http://publicationslist.org/esnault.v/refid24 2010-09-13T15:48:42Z

BACKGROUND: Graft-versus-host disease (GVHD) is a major complication after bone marrow transplantation, which may be refractory to immunosuppressive drugs. As preliminary case reports suggested that extracorporeal photochemotherapy (ECP) using a Therakos device might be beneficial, we conducted a pilot study to assess the efficacy and safety of a new ECP method that does not require administration...<br/><br/>D P Besnier, D Chabannes, B Mahé, J M Mussini, T A Baranger, J Y Muller, N Milpied, V L Esnault (1997) <i>Transplantation</i> <i></i> <i></i> 64: 1 49-54<br/>

http://publicationslist.org/esnault.v/refid27 2010-09-13T15:48:42Z

The vasculitic lesions observed in Wegener's granulomatosis may be partly the consequence of proteases released following activation of neutrophils by ANCA. The activity of these proteases, including proteinase 3 (PR3) and elastase, is normally closely restricted to the inflammation site by a large excess of circulating alpha-1-antitrypsin (alpha1AT). Patients with ANCA-positive systemic vasculiti...<br/><br/>V L Esnault, M A Audrain, R Sesboüé (1997) <i>Exp Clin Immunogenet</i> <i></i> <i></i> 14: 3 206-213<br/>

http://publicationslist.org/esnault.v/refid28 2010-09-13T15:48:42Z

Myeloperoxidase (MPO) is one of the main antigen targets of anti-neutrophil cytoplasmic antibodies (ANCA) in systemic vasculitides. It has been suggested that anti-MPO antibodies may recognize a single epitope on recombinant MPO. If confirmed on native MPO, this might allow specific therapeutic intervention with anti-idiotypic MoAbs to prevent antibody antigen interaction which is thought to cause...<br/><br/>M A Audrain, T A Baranger, N Moguilevski, S J Martin, A Devys, C M Lockwood, J Y Muller, V L Esnault (1997) <i>Clin Exp Immunol</i> <i></i> <i></i> 107: 1 127-134<br/>

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We previously reported the presence of immunoglobulin A (IgA) antineutrophil cytoplasmic antibodies (ANCAs) in patients presenting IgA nephropathy (IgAN), particularly when associated with Henoch-Schonlein purpura. Most of the patients exhibited IgA ANCAs directed at an unknown 50-kd neutrophil protein but no IgG ANCAs. A subgroup of patients presented IgG as well as IgA ANCAs, suggesting an overl...<br/><br/>S J Martin, M A Audrain, T Baranger, A Moreau, J Dantal, A Testa, V L Esnault (1997) <i>Am J Kidney Dis</i> <i></i> <i></i> 29: 1 125-131<br/>

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The american college of rheumatology (ACR) proposed in 1990 revised clinical criteria for systemic vasculitis classification to define homogeneous group of patients for clinical trials. However, microscopic polyarteritis (MPA) was not clearly identified from polyarteritis nodosa (PAN). Since anti-neutrophil cytoplasm antibodies (ANCA) are markers of disease activity of small vessel vasculitides in...<br/><br/>T A Baranger, M A Audrain, A Testa, D Besnier, L Guillevin, V L Esnault (1995) <i>Autoimmunity</i> <i></i> <i></i> 20: 1 33-37<br/>

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Circulating autoantibodies against the Goodpasture antigen (alpha 3 chain of type IV collagen) in the glomerular basement membrane (anti-GBM) and anti-neutrophil cytoplasm antibodies (ANCA) are each associated clinically with the development of a rapidly progressive glomerulonephritis. Antibodies with both these specificities coexist in a subset of patients, raising the possibility that they might...<br/><br/>A K Short, V L Esnault, C M Lockwood (1995) <i>Am J Kidney Dis</i> <i></i> <i></i> 26: 3 439-445<br/>

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ANCA are associated with certain forms of systemic vasculitis, and have been reported previously to be of the IgG and IgM isotype. We examined the possible association between IgA ANCA and the IgA-related diseases Henoch-Schönlein purpura (HSP) and IgA nephropathy (IgAN). IgA and IgG ANCA were detected by isotype-specific solid-phase assays with a crude neutrophil extract, and their presence was ...<br/><br/>N Ronda, V L Esnault, L Layward, V Sepe, A Allen, J Feehally, C M Lockwood (1994) <i>Clin Exp Immunol</i> <i></i> <i></i> 95: 1 49-55<br/>

http://publicationslist.org/esnault.v/refid37 2010-09-13T15:48:42Z

Crescentic glomerulonephritis is usually classified into antiglomerular basement membrane (GBM) disease, immune-complex disease, or pauci-immune crescentic nephritis. The last category includes patients with systemic vasculitis as well as 'idiopathic' isolated crescentic nephritis. The presence of anti-neutrophil cytoplasmic antibodies (ANCA) in many patients with apparently isolated crescentic ne...<br/><br/>R Angangco, S Thiru, V L Esnault, A K Short, C M Lockwood, D B Oliveira (1994) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 9: 6 630-636<br/>

http://publicationslist.org/esnault.v/refid35 2010-09-13T15:48:42Z

OBJECTIVE: To determine the prevalence of antineutrophil cytoplasmic antibodies (ANCA) in patients with active giant cell arteritis (GCA). METHODS: 23 patients with GCA were selected according to ACR 1990 criteria. Sera were harvested in all patients at an active stage of the disease and during followup (1 to 3 sera/patient for a total of 50 sera). ANCA positivity was searched for by indirect immu...<br/><br/>T A Baranger, M A Audrain, A Castagne, J H Barrier, V L Esnault (1994) <i>J Rheumatol</i> <i></i> <i></i> 21: 5 871-873<br/>

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We aimed at confirming the antigen specificity recognized by anti-neutrophil cytoplasm antibodies (ANCA) in patients presenting systemic vasculitis with anti-myeloperoxidase (MPO) activity on ELISA. Thirty-five consecutive patients with reactivity in anti-MPO ELISA and systemic microscopic vasculitides were tested in slot and Western blot analyses. Eleven of 35 sera exhibited binding in Western bl...<br/><br/>V L Esnault, A K Short, M A Audrain, S J Jones, S J Martin, J M Skehel, C M Lockwood (1994) <i>Kidney Int</i> <i></i> <i></i> 46: 1 153-160<br/>

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V L Esnault (1994) <i>Rev Prat</i> <i></i> <i></i> 44: 14 1971-1975<br/>

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Three sets of experiments were performed to investigate the quality of myeloperoxidase (MPO) preparations and anti-MPO reagents. In the first experiment, two groups of three and four mice were immunized with commercially purified MPO (Calbiochem). Immunization was performed in PBS in the first group and in acetate buffer in the second. From the first group, five monoclonals were raised, and their ...<br/><br/>M A Audrain, T A Baranger, C M Lockwood, V L Esnault (1994) <i>J Immunol Methods</i> <i></i> <i></i> 176: 1 23-31<br/>

http://publicationslist.org/esnault.v/refid43 2010-09-13T15:48:42Z

ANCA and anti-GBM antibodies can occur together in RPGN. These patients are rare and have two distinct populations of antibodies and the ANCA specificity tends to be for myeloperoxidase more often than expected.<br/><br/>A K Short, V L Esnault, C M Lockwood (1993) <i>Adv Exp Med Biol</i> <i></i> <i></i> 336: 441-444<br/>

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Thirty-five sera with binding greater than 20% in a myeloperoxidase (MPO, Calbiochem) ELISA were tested in Western blot analyses. 5/35 blotted MPO, but 5/35 blotted lactoferrin (LF) contaminating the commercial MPO preparation. All the anti-LF positive sera, but none of the anti-MPO positive sera, also exhibited anti-nuclear binding on Hep2 cells. Three of the patients with anti-LF antibodies had ...<br/><br/>V L Esnault, A K Short, S J Jones, M Skehel, J Walker, C M Lockwood (1993) <i>Adv Exp Med Biol</i> <i></i> <i></i> 336: 101-104<br/>

http://publicationslist.org/esnault.v/refid45 2010-09-13T15:48:42Z

We report the treatment of 5 patients with crescentic glomerulonephritis by immunoadsorption using a protein A column. Two had systemic vasculitis, 2 antiglomerular basement membrane disease and 1 systemic lupus erythematosus (SLE). In the patients with systemic vasculitis and SLE, there was successful removal of autoantibodies and rapid control of disease; remission was maintained over a mean fol...<br/><br/>V L Esnault, A Testa, D R Jayne, J P Soulillou, J Guenel (1993) <i>Nephron</i> <i></i> <i></i> 65: 2 180-184<br/>

http://publicationslist.org/esnault.v/refid42 2010-09-13T15:48:42Z

The presence of anti-idiotype antibody (anti-id) activity to anti-myeloperoxidase autoantibodies (anti-MPO) was measured by assessing binding of IgG in patients' sera to F(ab')2 fragments of polyclonal heterologous anti-MPO antiserum. Thirteen paired acute and remission sera and three groups of sequential sera from patients with systemic vasculitis were studied. The levels of anti-MPO fell as dise...<br/><br/>D R Jayne, V L Esnault, C M Lockwood (1993) <i>J Autoimmun</i> <i></i> <i></i> 6: 2 221-226<br/>

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The association of ANCA isotype and affinity with disease expression is reviewed and new data on IgA ANCA levels and affinity in relation to disease activity are presented. Differences in the IgG ANCA subclass distribution exist between active disease and remission, with high affinity IgG3 ANCA present at the onset of disease. IgM ANCA, with or without associated IgG ANCA, correlates with pulmonar...<br/><br/>V L Esnault, N Ronda, D R Jayne, C M Lockwood (1993) <i>J Autoimmun</i> <i></i> <i></i> 6: 2 197-205<br/>

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Necrotizing leucocytoclastic vasculitis is the histopathological hallmark of the small vessel systemic vasculitides (SV), a group of human diseases commonly associated with anti-neutrophil cytoplasm autoantibodies (ANCA). Necrotizing vasculitis is seen in a number of experimental systems, but none of these provide an ideal animal model for human SV. Vasculitis occurs in serum sickness reactions; i...<br/><br/>P W Mathieson, F J Qasim, V L Esnault, D B Oliveira (1993) <i>J Autoimmun</i> <i></i> <i></i> 6: 2 251-264<br/>

http://publicationslist.org/esnault.v/refid38 2010-09-13T15:48:42Z

Alpha 1-antitrypsin (alpha 1-AT) is the major inhibitor of proteinase 3 (PR3), the main target antigen of antineutrophil cytoplasm antibodies (ANCA) in Wegener's granulomatosis. alpha 1-AT is encoded by a polymorphic gene, with over 75 alleles, defining severely, medium and non-deficient protease inhibitor (PI) phenotypes. We describe the association of severely and medium deficient PI phenotypes ...<br/><br/>V L Esnault, A Testa, M Audrain, C Rogé, M Hamidou, J H Barrier, R Sesboüé, J P Martin, P Lesavre (1993) <i>Kidney Int</i> <i></i> <i></i> 43: 6 1329-1332<br/>

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The presence of anti-idiotype antibodies (anti-id) to anti-neutrophil cytoplasm autoantibodies (ANCA) in intravenous immunoglobulin (IVIg) and remission sera from patients with systemic vasculitis, and the use of IVIg as an alternative therapeutic agent in open studies, has suggested a role for idiotypic regulation in the normal control of these disorders. Clinical benefit with IVIg has been repor...<br/><br/>D R Jayne, V L Esnault, C M Lockwood (1993) <i>J Autoimmun</i> <i></i> <i></i> 6: 2 207-219<br/>

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V L Esnault (1992) <i>Ann Med Interne (Paris)</i> <i></i> <i></i> 143: 6 399-400<br/>

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V L Esnault, C M Lockwood (1992) <i>Nephrologie</i> <i></i> <i></i> 13: 6 275-277<br/>

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ANCA are markers for systemic vasculitis such as Wegener's granulomatosis (WG) and microscopic polyarteritis (MPA) and are usually of the IgG isotype. However, IgM ANCA may rarely occur in isolation, and in these circumstances, we have found that they are associated clinically with a syndrome of pulmonary hemorrhage and systemic vasculitis. How frequently IgM ANCA may occur in conjunction with IgG...<br/><br/>V L Esnault, B Soleimani, M T Keogan, A A Brownlee, D R Jayne, C M Lockwood (1992) <i>Kidney Int</i> <i></i> <i></i> 41: 5 1304-1310<br/>

http://publicationslist.org/esnault.v/refid47 2010-09-13T15:48:42Z

BACKGROUND: Mercuric chloride (HgCl2) induces an autoimmune syndrome in Brown Norway (BN) rats characterized by the presence of a number of autoantibodies, including antibodies to glomerular basement membrane. Tissue injury has previously been reported to be rare in this model, but in the accompanying paper we describe changes in a number of organs including a necrotizing leucocytoclastic vasculit...<br/><br/>V L Esnault, P W Mathieson, S Thiru, D B Oliveira, C Martin-Lockwood (1992) <i>Lab Invest</i> <i></i> <i></i> 67: 1 114-120<br/>

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D M Thomas, R Moore, K Donovan, D C Wheeler, V L Esnault, C M Lockwood (1992) <i>Lancet</i> <i></i> <i></i> 339: 8804 <br/>

http://publicationslist.org/esnault.v/refid46 2010-09-13T15:48:42Z

Anti-neutrophil cytoplasm antibodies (ANCA) are markers of systemic vasculitis for which a pathogenetic role has been postulated. We have examined the effect of these autoantibodies on the function of normal human neutrophils in vitro. In the presence of ANCA positive sera luminol-amplified chemiluminescence was significantly increased compared to the values seen in the presence of normal or anti-...<br/><br/>M T Keogan, V L Esnault, A J Green, C M Lockwood, D L Brown (1992) <i>Clin Exp Immunol</i> <i></i> <i></i> 90: 2 228-234<br/>

http://publicationslist.org/esnault.v/refid52 2010-09-13T15:48:42Z

Circulating IgG autoantibodies to myeloperoxidase (MPO) are associated with renal vasculitis and have been implicated in its pathogenesis. However, raised levels of these autoantibodies may persist during clinical remission. We tested whether this paradox could be explained by immunoglobulin subclass switching during disease evolution, since different subclasses have different immunological and bi...<br/><br/>V L Esnault, D R Jayne, A P Weetman, C M Lockwood (1991) <i>Immunology</i> <i></i> <i></i> 74: 4 714-718<br/>

http://publicationslist.org/esnault.v/refid53 2010-09-13T15:48:42Z

Strenuous physical exercise causes transient proteinuria and renal hemodynamic changes: decrease of renal blood flow and to a lesser extent of the glomerular filtration rate, and an increase of the filtration fraction. However, the mechanisms of these modifications are still poorly understood. In order to elucidate them we performed maximal exercise tests on 8 untrained healthy volunteers after in...<br/><br/>V L Esnault, M Potiron-Josse, A Testa, J D Ginet, D Le Carrer, J Guenel (1991) <i>Nephron</i> <i></i> <i></i> 58: 4 437-442<br/>

http://publicationslist.org/esnault.v/refid54 2010-09-13T15:48:42Z

Anti-neutrophil cytoplasm antibodies (ANCA) are specific markers for systemic vasculitis. In view of the autoreactivity to other autoantigens reported in patients with monoclonal immunoglobulins (MIg), the reactivity of 150 sera from 125 patients with MIg was tested for ANCA by radioimmunoassay (RIA) with inhibition stage and indirect immunofluorescence (IIF). Seven were positive for IgG ANCA, all...<br/><br/>V L Esnault, D R Jayne, M T Keogan, A A Brownlee, A Testa, D Lecarrer, D L Brown, C M Lockwood (1990) <i>J Clin Lab Immunol</i> <i></i> <i></i> 32: 4 153-159<br/>