http://publicationslist.org/data/franclim.ribeiro/atom.xml Franclim Ribeirohttp://publicationslist.org/franclim.ribeiro$basepathfavicon.icoRecent additions to Franclim Ribeiro's PublicationsList.org pagehttp://publicationslist.org/publications.png2026-07-03T09:17:08Z http://publicationslist.org/franclim.ribeiro/refid93 2026-07-03T09:14:11Z

Despite the clinical validation and unequivocal benefit to patients, the development of cancer immunotherapies is facing some key challenges and the attrition rate in early phases of development remains high. Identifying the appropriate patient population that would benefit most from the drug is on the critical path for successful clinical development. We believe that a systematic implementation o...<br/><br/>Michael A Cannarile, Vaios Karanikas, Bernhard Reis, Christoph Mancao, Eleni Lagkadinou, Dominik Rüttinger, Natascha Rieder, Franclim R Ribeiro, Henry Kao, Sebastian Dziadek, Bruno Gomes (2024) <i>Clinical cancer research : an official journal of the American Association for Cancer Research</i> <i></i> <i></i> 30: 8 1448-1456<br/>

http://publicationslist.org/franclim.ribeiro/refid91 2026-07-03T08:54:37Z

Epigenetic alterations are common in prostate cancer (PCa) and seem to contribute decisively to its initiation and progression. Moreover, aberrant promoter methylation is a promising biomarker for non-invasive screening. Herein, we sought to characterize EFEMP1 as biomarker for PCa, unveiling its biological relevance in prostate carcinogenesis. Microarray analyses of treated PCa cell lines and pri...<br/><br/>Mafalda Almeida, Vera L Costa, Natália R Costa, João Ramalho-Carvalho, Tiago Baptista, Franclim R Ribeiro, Paula Paulo, Manuel R Teixeira, Jorge Oliveira, Ragnhild A Lothe, Guro E Lind, Rui Henrique, Carmen Jerónimo (2014) <i>Journal of cellular and molecular medicine</i> <i></i> <i></i> 18: 11 2287-2297<br/>

http://publicationslist.org/franclim.ribeiro/refid80 2026-07-03T08:54:26Z

This work aimed to evaluate whether ETS transcription factors frequently involved in rearrangements in prostate carcinomas (PCa), namely ERG and ETV1, regulate specific or shared target genes. We performed differential expression analysis on nine normal prostate tissues and 50 PCa enriched for different ETS rearrangements using exon-level expression microarrays, followed by in vitro validation usi...<br/><br/>Paula Paulo, Franclim R Ribeiro, Joana Santos, Diana Mesquita, Mafalda Almeida, João D Barros-Silva, Harri Itkonen, Rui Henrique, Carmen Jerónimo, Anita Sveen, Ian G Mills, Rolf I Skotheim, Ragnhild A Lothe, Manuel R Teixeira (2012) <i>Neoplasia</i> <i></i> <i></i> 14: 7 600-611<br/>

http://publicationslist.org/franclim.ribeiro/refid83 2026-07-03T08:54:26Z

FLI1 and ERG, the major ETS transcription factors involved in rearrangements in the Ewing's sarcoma family of tumors (ESFT) and in prostate carcinomas (PCa), respectively, belong to the same subfamily, having 98% sequence identity in the DNA binding domain. We therefore decided to investigate whether the aberrant transcription factors in both malignancies have some common downstream targets. We cr...<br/><br/>Maria J Camões, Paula Paulo, Franclim R Ribeiro, João D Barros-Silva, Mafalda Almeida, Vera L Costa, Nuno Cerveira, Rolf I Skotheim, Ragnhild A Lothe, Rui Henrique, Carmen Jerónimo, Manuel R Teixeira (2012) <i>PLoS One</i> <i></i> <i></i> 7: 11 <br/>

http://publicationslist.org/franclim.ribeiro/refid72 2026-07-03T08:54:13Z

To characterize the pattern of ETS rearrangements and to uncover novel ETS fusion genes, we analyzed 200 prostate carcinomas (PCa) with TaqMan low-density arrays (TLDAs), followed by selective analyses with fluorescence in situ hybridization (FISH), RT-PCR, and sequencing. Besides confirming the recurrent presence of ERG, ETV1, ETV4, and ETV5 rearrangements, we here report FLI1 as the fifth ETS tr...<br/><br/>Paula Paulo, João D Barros-Silva, Franclim R Ribeiro, João Ramalho-Carvalho, Carmen Jerónimo, Rui Henrique, Guro E Lind, Rolf I Skotheim, Ragnhild A Lothe, Manuel R Teixeira (2012) <i>Genes Chromosomes Cancer</i> <i></i> <i></i> 51: 3 240-249<br/>

http://publicationslist.org/franclim.ribeiro/refid59 2026-07-03T08:53:39Z

The OPCML gene (opioid binding protein/cell adhesion molecule-like), a putative tumour suppressor gene, is frequently inactivated in carcinomas, namely through aberrant promoter methylation. Herein, we aimed to determine whether OPCML altered expression mediated by epigenetic mechanisms was implicated in bladder carcinogenesis and to assess its potential as a bladder cancer epi-marker. OPCML promo...<br/><br/>Sara Duarte-Pereira, Filipa Paiva, Vera Lúcia Costa, João Ramalho-Carvalho, Joana Savva-Bordalo, Angelo Rodrigues, Franclim Ricardo Ribeiro, Vitor M Silva, Jorge Oliveira, Rui Henrique, Carmen Jerónimo (2011) <i>Eur J Cancer</i> <i></i> <i></i> 47: 7 1106-1114<br/>

http://publicationslist.org/franclim.ribeiro/refid58 2026-07-03T08:53:39Z

The KRT19 gene encodes cytokeratin 19, an element of the cytoskeleton whose expression is frequently altered in renal cell carcinoma (RCC). Epigenetic phenomena, such as promoter methylation, may be a regulatory mechanism of expression of this gene. The aim of this study was to assess the epigenetic regulation of the KRT19 gene using epigenetic-modulating drugs, through the evaluation of methylati...<br/><br/>Filipa Paiva, Sara Duarte-Pereira, Vera Lúcia Costa, João Ramalho-Carvalho, Patrícia Patrício, Franclim Ricardo Ribeiro, Francisco Lobo, Jorge Oliveira, Carmen Jerónimo, Rui Henrique (2011) <i>DNA Cell Biol</i> <i></i> <i></i> 30: 2 85-90<br/>

http://publicationslist.org/franclim.ribeiro/refid82 2026-07-03T08:54:26Z

A large percentage of prostate cancers harbor TMPRSS2-ERG gene fusions, leading to aberrant overexpression of the transcription factor ERG. The target genes deregulated by this rearrangement, however, remain mostly unknown. To address this subject we performed genome-wide mRNA expression analysis on 6 non-malignant prostate samples and 24 prostate carcinomas with (n = 16) and without (n = ...<br/><br/>Franclim R Ribeiro, Paula Paulo, Vera L Costa, João D Barros-Silva, João Ramalho-Carvalho, Carmen Jerónimo, Rui Henrique, Guro E Lind, Rolf I Skotheim, Ragnhild A Lothe, Manuel R Teixeira (2011) <i>PLoS One</i> <i></i> <i></i> 6: 7 <br/>

http://publicationslist.org/franclim.ribeiro/refid71 2026-07-03T08:54:13Z

Screening tools have greatly improved prostate cancer (PCa) detection, but the disease course is heterogeneous, and standard clinicopathological parameters do not fully discriminate aggressive from indolent tumors. To evaluate the prognostic value of the TMPRSS2-ERG fusion gene combined with chromosome arm 8q relative gain in diagnostic biopsies of PCa, we studied a consecutive series of 200 diagn...<br/><br/>João D Barros-Silva, Franclim R Ribeiro, Angelo Rodrigues, Ricardo Cruz, Ana T Martins, Carmen Jerónimo, Rui Henrique, Manuel R Teixeira (2011) <i>Genes Chromosomes Cancer</i> <i></i> <i></i> 50: 8 662-671<br/>

http://publicationslist.org/franclim.ribeiro/refid57 2026-07-03T08:53:39Z

Apoptosis is known to be involved in tumorigenesis and a defective ratio between cell proliferation and apoptosis may contribute to the emergence of a malignant phenotype. Transcriptional silencing of apoptosis-related genes associated with aberrant promoter methylation may impair the apoptotic machinery, ultimately leading to cancer development. Aberrant promoter methylation of numerous genes inv...<br/><br/>João R Carvalho, Luísa Filipe, Vera L Costa, Franclim Ricardo Ribeiro, Ana T Martins, Manuel R Teixeira, Carmen Jerónimo, Rui Henrique (2010) <i>Apoptosis</i> <i></i> <i></i> 15: 8 956-965<br/>

http://publicationslist.org/franclim.ribeiro/refid81 2026-07-03T08:54:26Z

The association of a genetic analysis that could improve the diagnostic accuracy of renal cell tumors in biopsy samples would allow better-informed therapeutic decisions. We performed comparative genomic hybridization (CGH) on an ex vivo fine-needle aspiration (FNA) biopsy and a tumor fragment obtained from 75 patients consecutively diagnosed with renal tumors and subjected to radical nephrectomy....<br/><br/>Joana Vieira, Rui Henrique, Franclim R Ribeiro, João D Barros-Silva, Ana Peixoto, Catarina Santos, Manuela Pinheiro, Vera L Costa, Maria J Soares, Jorge Oliveira, Carmen Jerónimo, Manuel R Teixeira (2010) <i>Genes Chromosomes Cancer</i> <i></i> <i></i> 49: 10 935-947<br/>

http://publicationslist.org/franclim.ribeiro/refid92 2026-07-03T08:54:37Z

Septins are proteins associated with crucial steps in cell division and cellular integrity. In humans, 14 septin genes have been identified, of which five (SEPT2, SEPT5, SEPT6, SEPT9, and SEPT11) are known to participate in reciprocal translocations with the MLL gene in myeloid neoplasias. We have recently shown a significant down-regulation of both SEPT2 and MLL in myeloid neoplasias with the MLL...<br/><br/>Joana Santos, Nuno Cerveira, Susana Bizarro, Franclim R Ribeiro, Cecília Correia, Lurdes Torres, Susana Lisboa, Joana Vieira, José M Mariz, Lucília Norton, Simone Snijder, Clemens H Mellink, Arjan Buijs, Lee-Yung Shih, Sabine Strehl, Francesca Micci, Sverre Heim, Manuel R Teixeira (2010) <i>Leuk Res</i> <i></i> <i></i> 34: 5 615-621<br/>

http://publicationslist.org/franclim.ribeiro/refid87 2026-07-03T08:54:26Z

PURPOSE The purpose of this study was to identify genetic aberrations contributing to clinical aggressiveness of malignant peripheral nerve sheath tumors (MPNSTs). PATIENTS AND METHODS Samples from 48 MPNSTs and 10 neurofibromas were collected from 51 patients with (n = 31) or without (n = 20) neurofibromatosis type 1 (NF1). Genome-wide DNA copy number changes were assessed by chromosomal and arra...<br/><br/>Helge R Brekke, Franclim R Ribeiro, Matthias Kolberg, Trude H Agesen, Guro E Lind, Mette Eknæs, Kirsten S Hall, Bodil Bjerkehagen, Eva van den Berg, Manuel R Teixeira, Nils Mandahl, Sigbjørn Smeland, Fredrik Mertens, Rolf I Skotheim, Ragnhild A Lothe (2010) <i>J Clin Oncol</i> <i></i> <i></i> 28: 9 1573-1582<br/>

http://publicationslist.org/franclim.ribeiro/refid86 2026-07-03T08:54:26Z

BACKGROUND: Oncogenic point mutations in KIT or PDGFRA are recognized as the primary events responsible for the pathogenesis of most gastrointestinal stromal tumors (GIST), but additional genomic alterations are frequent and presumably required for tumor progression. The relative contribution of such alterations for the biology and clinical behavior of GIST, however, remains elusive. METHODS: In t...<br/><br/>Mara Silva, Isabel Veiga, Franclim R Ribeiro, Joana Vieira, Carla Pinto, Manuela Pinheiro, Bárbara Mesquita, Catarina Santos, Marta Soares, José Dinis, Lúcio Santos, Paula Lopes, Mariana Afonso, Carlos Lopes, Manuel R Teixeira (2010) <i>BMC Med</i> <i></i> <i></i> 8: 1 <br/>

http://publicationslist.org/franclim.ribeiro/refid35 2026-07-03T08:52:54Z

Constitutive activation of the Wnt signaling pathway is a common feature of solid tumors and contributes to uncontrolled cell-growth and impaired differentiation. We hypothesized that gene silencing mediated through aberrant promoter methylation of upstream Wnt antagonist genes might result in beta-catenin accumulation, resulting in constitutive Wnt activation. Wnt antagonist genes (SFRP1, WIF1, A...<br/><br/>Vera L Costa, Rui Henrique, Franclim R Ribeiro, João R Carvalho, Jorge Oliveira, Francisco Lobo, Manuel R Teixeira, Carmen Jerónimo (2010) <i>Epigenetics</i> <i></i> <i></i> 5: 4 343-351<br/>

http://publicationslist.org/franclim.ribeiro/refid62 2026-07-03T08:53:56Z

BACKGROUND: The ability to detect neoplasia-specific fusion genes is important not only in cancer research, but also increasingly in clinical settings to ensure that correct diagnosis is made and the optimal treatment is chosen. However, the available methodologies to detect such fusions all have their distinct short-comings. RESULTS: We describe a novel oligonucleotide microarray strategy whereby...<br/><br/>Rolf I Skotheim, Gard O S Thomassen, Marthe Eken, Guro E Lind, Francesca Micci, Franclim R Ribeiro, Nuno Cerveira, Manuel R Teixeira, Sverre Heim, Torbjørn Rognes, Ragnhild A Lothe (2009) <i>Mol Cancer</i> 8: 5<br/>

http://publicationslist.org/franclim.ribeiro/refid74 2026-07-03T08:54:13Z

BACKGROUND: A relevant role of septins in leukemogenesis has been uncovered by their involvement as fusion partners in MLL-related leukemia. Recently, we have established the MLL-SEPT2 gene fusion as the molecular abnormality subjacent to the translocation t(2;11)(q37;q23) in therapy-related acute myeloid leukemia. In this work we quantified MLL and SEPT2 gene expression in 58 acute myeloid leukem...<br/><br/>Nuno Cerveira, Joana Santos, Susana Bizarro, Vera Costa, Franclim R Ribeiro, Susana Lisboa, Cecília Correia, Lurdes Torres, Joana Vieira, Simone Snijder, José M Mariz, Lucília Norton, Clemens H Mellink, Arjan Buijs, Manuel R Teixeira (2009) <i>BMC Cancer</i> <i></i> <i></i> 9: <br/>

http://publicationslist.org/franclim.ribeiro/refid20 2026-07-03T08:52:31Z

BACKGROUND: Cell lines are often poorly characterized from a genetic point of view, reducing their usefulness as tumor models. Our purpose was to assess the genetic background of eight commonly used human thyroid carcinoma models and to compare the findings with those reported for primary tumors of the gland. METHODS: We used chromosome banding analysis and comparative genomic hybridization to pro...<br/><br/>Franclim Ricardo Ribeiro, Ana Margarida Meireles, Ana Sofia Rocha, Manuel Rodrigues Teixeira (2008) <i>BMC Cancer</i> 8: 371<br/>

http://publicationslist.org/franclim.ribeiro/refid36 2026-07-03T08:52:54Z

BACKGROUND: A defective mitotic checkpoint has been proposed to contribute to chromosomal instability (CIN). We have previously shown that expression changes of the mitotic arrest deficiency (MAD) gene family plays a role in renal cell cancer (RCC) characterized by numerical chromosomal changes, namely papillary and chromophobe carcinomas, but nothing is known about the expression of mitotic check...<br/><br/>Mafalda Pinto, Joana Vieira, Franclim R Ribeiro, Maria J Soares, Rui Henrique, Jorge Oliveira, Carmen Jerónimo, Manuel R Teixeira (2008) <i>Cell Oncol</i> <i></i> <i></i> 30: 5 389-395<br/>

http://publicationslist.org/franclim.ribeiro/refid28 2026-07-03T08:52:42Z

Franclim R Ribeiro, Rolf I Skotheim, Rui Henrique, Manuel R Teixeira (2008) <i>Methods of Cancer Diagnosis, Therapy and Prognosis</i> <br/>

http://publicationslist.org/franclim.ribeiro/refid34 2026-07-03T08:52:54Z

Papillary and chromophobe renal cell carcinomas are characterized by multiple trisomies and monosomies, respectively, but the molecular mechanisms behind the acquisition of these numerical chromosome changes are unknown. To evaluate the role of mitotic checkpoint defects for the karyotypic patterns characteristic of these two renal cell cancer subtypes, we analyzed the messenger RNA expression lev...<br/><br/>Mafalda Pinto, Maria J Soares, Nuno Cerveira, Rui Henrique, Franclim R Ribeiro, Jorge Oliveira, Carmen Jerónimo, Manuel R Teixeira (2007) <i>Virchows Arch</i> <i></i> <i></i> 450: 4 379-385<br/>

http://publicationslist.org/franclim.ribeiro/refid33 2026-07-03T08:52:54Z

BACKGROUND: Aberrant promoter hypermethylation of cancer-associated genes occurs frequently during carcinogenesis and may serve as a cancer biomarker. In this study we aimed at defining a quantitative gene promoter methylation panel that might identify the most prevalent types of renal cell tumors. METHODS: A panel of 18 gene promoters was assessed by quantitative methylation-specific PCR (QMSP) i...<br/><br/>Vera L Costa, Rui Henrique, Franclim R Ribeiro, Mafalda Pinto, Jorge Oliveira, Francisco Lobo, Manuel R Teixeira, Carmen Jerónimo (2007) <i>BMC Cancer</i> 7: 133<br/>

http://publicationslist.org/franclim.ribeiro/refid23 2026-07-03T08:52:31Z

Conflicting theories of epithelial carcinogenesis disagree on the clonal composition of primary tumors and on the time at which metastases occur. In order to study the spatial distribution of disparate clonal populations within breast carcinomas and the extent of the genetic relationship between primary tumors and regional metastases, we have analyzed by comparative genomic hybridization 122 tissu...<br/><br/>Lurdes Torres, Franclim R Ribeiro, Nikos Pandis, Johan A Andersen, Sverre Heim, Manuel R Teixeira (2007) <i>Breast Cancer Res Treat</i> <i></i> <i></i> 102: 2 143-155<br/>

http://publicationslist.org/franclim.ribeiro/refid63 2026-07-03T08:53:56Z

PURPOSE: Prostate cancer is a highly prevalent malignancy and constitutes a major cause of cancer-related morbidity and mortality. Owing to the limitations of current clinical, serologic, and pathologic parameters in predicting disease progression, we sought to investigate the prognostic value of promoter methylation of a small panel of genes by quantitative methylation-specific PCR (QMSP) in pros...<br/><br/>Rui Henrique, Franclim R Ribeiro, Daniel Fonseca, Mohammad O Hoque, André L Carvalho, Vera L Costa, Mafalda Pinto, Jorge Oliveira, Manuel R Teixeira, David Sidransky, Carmen Jerónimo (2007) <i>Clin Cancer Res</i> <i></i> <i></i> 13: 20 6122-6129<br/>

http://publicationslist.org/franclim.ribeiro/refid2 2026-07-03T08:51:22Z

OBJECTIVES: We have recently shown using comparative genomic hybridization (CGH) that 8q gain is an independent predictor of poor survival for prostate cancer patients. Because CGH may be difficult to implement in the clinical practice, we tested the feasibility of using a three-color fluorescent assay to assess 8q status in diagnostic, paraffin-embedded biopsy samples from prostate cancer patient...<br/><br/>Franclim R Ribeiro, Rui Henrique, Ana T Martins, Carmen Jerónimo, Manuel R Teixeira (2007) <i>Eur Urol</i> <i></i> <i></i> 52: 1 116-125<br/>

http://publicationslist.org/franclim.ribeiro/refid64 2026-07-03T08:53:56Z

D-type cyclins play a pivotal role in cell cycle regulation and their abnormal expression was associated with several human malignancies. To assess Cyclin D2 promoter methylation status and expression levels in prostate tissues, quantitative methylation-specific PCR and quantitative reverse transcription PCR assays were performed in a large series of prostate carcinomas, high-grade prostatic intra...<br/><br/>Rui Henrique, Vera Lúcia Costa, Nuno Cerveira, André Lopes Carvalho, Mohammad Obaidul Hoque, Franclim Ricardo Ribeiro, Jorge Oliveira, Manuel Rodrigues Teixeira, David Sidransky, Carmen Jerónimo (2006) <i>J Mol Med</i> <i></i> <i></i> 84: 11 911-918<br/>

http://publicationslist.org/franclim.ribeiro/refid7 2026-07-03T08:51:22Z

PURPOSE: The main procedure to confirm a suspected diagnosis of prostate cancer is histologic analysis of ultrasound-guided sextant prostate biopsies. As it is difficult to reliably assess tumor stage and grade in such minute samples, the clinical significance of some tumor foci remains unclear. Genetic markers that could augment pretreatment prognostic information would improve the clinical manag...<br/><br/>Franclim R Ribeiro, Carmen Jerónimo, Rui Henrique, Daniel Fonseca, Jorge Oliveira, Ragnhild A Lothe, Manuel R Teixeira (2006) <i>Clin Cancer Res</i> <i></i> <i></i> 12: 13 3961-3970<br/>

http://publicationslist.org/franclim.ribeiro/refid5 2026-07-03T08:51:22Z

Epithelioid hemangioendothelioma is a rare, well-differentiated endothelial tumor with a wide spectrum of clinical behavior and for which genetic data are extremely limited. We present a case of an epithelioid hemangioendothelioma in a 22-year-old male, which was analyzed with multiple cytogenetic approaches. Conventional cytogenetic analysis detected structural abnormalities of 11q13 and 11q14, r...<br/><br/>Haroula Tsarouha, Anastasios I Kyriazoglou, Franclim R Ribeiro, Manuel R Teixeira, Niki Agnantis, Nikos Pandis (2006) <i>Cancer Genet Cytogenet</i> <i></i> <i></i> 169: 2 164-168<br/>

http://publicationslist.org/franclim.ribeiro/refid4 2026-07-03T08:51:22Z

BACKGROUND: In order to gain new insights into the molecular mechanisms involved in prostate cancer, we performed array-based comparative genomic hybridization (aCGH) on a series of 46 primary prostate carcinomas using a 1 Mbp whole-genome coverage platform. As chromosomal comparative genomic hybridization (cCGH) data was available for these samples, we compared the sensitivity and overall concord...<br/><br/>Franclim R Ribeiro, Rui Henrique, Merete Hektoen, Marianne Berg, Carmen Jerónimo, Manuel R Teixeira, Ragnhild A Lothe (2006) <i>Mol Cancer</i> <i></i> <i></i> 5: <br/>

http://publicationslist.org/franclim.ribeiro/refid3 2026-07-03T08:51:22Z

TMPRSS2-ETS gene fusions have been found recurrently in prostate carcinomas, but not in the presumed precursor lesion, high-grade prostatic intraepithelial neoplasia (HGPIN). However, HGPIN lesions may share chromosomal changes with prostate cancer. To determine the relative order of genetic events in prostate carcinogenesis, we have analyzed 34 prostate carcinomas, 19 paired HGPIN lesions, 14 ben...<br/><br/>Nuno Cerveira, Franclim R Ribeiro, Ana Peixoto, Vera Costa, Rui Henrique, Carmen Jerónimo, Manuel R Teixeira (2006) <i>Neoplasia</i> <i></i> <i></i> 8: 10 826-832<br/>

http://publicationslist.org/franclim.ribeiro/refid24 2026-07-03T08:52:42Z

To identify chromosomal aberrations that differentiate among the Dukes' stages of colorectal cancer (CRC) as well as those that are responsible for the progression into liver metastases, we performed a meta-analysis of data obtained from 31 comparative genomic hybridization (CGH) studies comprising a total of 859 CRCs. Individual copy number profiles for 373 primary tumors and 102 liver metastases...<br/><br/>Chieu B Diep, Kristine Kleivi, Franclim R Ribeiro, Manuel R Teixeira, Ole C Lindgjaerde, Ragnhild A Lothe (2006) <i>Genes Chromosomes Cancer</i> <i></i> <i></i> 45: 1 31-41<br/>

http://publicationslist.org/franclim.ribeiro/refid67 2026-07-03T08:53:56Z

Molecular markers that could stratify prostate cancer patients according to risk of disease progression would allow a significant improvement in the management of this clinically heterogeneous disease. In the present study, we analyzed the genetic profile of a consecutive series of 51 clinically confined prostate carcinomas and 27 benign prostatic hyperplasias using comparative genomic hybridizati...<br/><br/>Franclim R Ribeiro, Chieu B Diep, Carmen Jerónimo, Rui Henrique, Carlos Lopes, Mette Eknaes, Ole Christian Lingjaerde, Ragnhild A Lothe, Manuel R Teixeira (2006) <i>Genes Chromosomes Cancer</i> <i></i> <i></i> 45: 2 154-163<br/>

http://publicationslist.org/franclim.ribeiro/refid65 2026-07-03T08:53:56Z

High-grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostate adenocarcinoma, but the frequency and timing of epigenetic changes found in prostate carcinogenesis has not been extensively documented. Thus, the promoters of three genes (APC, GSTP1, and RARbeta2) involved in prostate carcinogenesis were tested by quantitative methylation-specific PCR in tissue DNA from...<br/><br/>Rui Henrique, Carmen Jerónimo, Manuel R Teixeira, Mohammad O Hoque, André L Carvalho, Irene Pais, Franclim R Ribeiro, Jorge Oliveira, Carlos Lopes, David Sidransky (2006) <i>Mol Cancer Res</i> <i></i> <i></i> 4: 1 1-8<br/>

http://publicationslist.org/franclim.ribeiro/refid66 2026-07-03T08:53:56Z

The most common types of rhabdomyosarcoma (RMS) are alveolar RMS (ARMS), which are characterized by the specific translocation t(2;13)(q35;q14) or its rarer variant, t(1;13)(p36;q14), producing the fusion genes PAX3-FKHR and PAX7-FKHR, respectively, and embryonal RMS (ERMS), which is characterized by multiple numeric chromosome changes. A solid variant of ARMS that is morphologically indistinguish...<br/><br/>Nuno Cerveira, Lurdes Torres, Franclim R Ribeiro, Rui Henrique, Armando Pinto, Susana Bizarro, Ana M Ferreira, Carlos Lopes, Manuel R Teixeira (2005) <i>Cancer Genet Cytogenet</i> <i></i> <i></i> 163: 2 138-143<br/>

http://publicationslist.org/franclim.ribeiro/refid69 2026-07-03T08:53:56Z

Retinoic acid receptor beta2 (RARbeta2) is a tumor suppressor gene frequently hypermethylated in several human neoplasms. To further characterize this epigenetic alteration in prostate cancer progression, we examined tumor tissue from 118 patients with prostate carcinoma (PCa), 38 paired high-grade prostatic intraepithelial neoplasias (HGPIN), and non-neoplastic prostate tissue from 30 patients wi...<br/><br/>Carmen Jerónimo, Rui Henrique, Mohammad O Hoque, Franclim R Ribeiro, Jorge Oliveira, Daniel Fonseca, Manuel R Teixeira, Carlos Lopes, David Sidransky (2004) <i>Clin Cancer Res</i> 10: 12 Pt 1 4010-4014<br/>

http://publicationslist.org/franclim.ribeiro/refid68 2026-07-03T08:53:56Z

PURPOSE: Promoter hypermethylation is an alternative pathway for gene silencing in neoplastic cells and a promising cancer detection marker. Although quantitative methylation-specific PCR (QMSP) of the GSTP1 promoter has demonstrated near perfect specificity for cancer detection in prostate biopsies, we postulated that identification and characterization of additional methylation markers might fur...<br/><br/>Carmen Jerónimo, Rui Henrique, Mohammad O Hoque, Elizabeth Mambo, Franclim R Ribeiro, Graça Varzim, Jorge Oliveira, Manuel R Teixeira, Carlos Lopes, David Sidransky (2004) <i>Clin Cancer Res</i> <i></i> <i></i> 10: 24 8472-8478<br/>

http://publicationslist.org/franclim.ribeiro/refid25 2026-07-03T08:52:42Z

The issue of whether multiple, ipsilateral or bilateral, breast carcinomas represent multiple primary tumours or dissemination of a single carcinomatous process has been difficult to resolve, especially for individual patients. We have addressed the problem by comparative genomic hybridisation analysis of 26 tumours from 12 breast cancer patients with multiple ipsilateral and/or bilateral carcinom...<br/><br/>Manuel R Teixeira, Franclim R Ribeiro, Lurdes Torres, Nikos Pandis, Johan A Andersen, Ragnhild A Lothe, Sverre Heim (2004) <i>Br J Cancer</i> <i></i> <i></i> 91: 4 775-782<br/>

http://publicationslist.org/franclim.ribeiro/refid14 2026-07-03T08:52:11Z

BACKGROUND: The widespread use of prostate-specific antigen (PSA) testing to screen for prostate carcinoma has led to significant overdiagnosis, due to the frequent detection of indolent malignancies on PSA screening. The detection of abnormal PSA levels typically is followed by ultrasound-guided needle biopsy. Therefore, in an effort to identify genetic markers that augment the information provid...<br/><br/>Manuel R Teixeira, Franclim R Ribeiro, Mette Eknaes, Håkon Waehre, Anna E Stenwig, Karl E Giercksky, Sverre Heim, Ragnhild A Lothe (2004) <i>Cancer</i> <i></i> <i></i> 101: 8 1786-1793<br/>

http://publicationslist.org/franclim.ribeiro/refid9 2026-07-03T08:51:22Z

Clear cell sarcoma of tendons and aponeuroses (CCS) is an uncommon malignancy characterized by a t(12;22)(q13;q12) causing a fusion of the EWS and ATF1 genes. We describe the cytogenetic and molecular genetic analyses of two lung metastases from a CCS patient. Both lesions presented the defining t(12;22) and a type 1 EWS/ATF1 chimeric transcript. The additional cytogenetic changes present in the t...<br/><br/>Manuel R Teixeira, Franclim R Ribeiro, Nuno Cerveira, Lurdes Torres, Teresina Amaro, Rui Henrique, Carlos Lopes (2003) <i>Cancer Genet Cytogenet</i> <i></i> <i></i> 145: 2 121-125<br/>