http://publicationslist.org/data/frank.dor/atom.xml Frank Dor, MD PhDhttp://publicationslist.org/frank.dor$basepathfavicon.icoRecent additions to Frank Dor, MD PhD's PublicationsList.org pagehttp://publicationslist.org/publications.png2012-06-17T15:25:41Z http://publicationslist.org/frank.dor/refid51 2012-05-23T11:36:00Z

Karel W J Klop, Oguzhan Karatepe, Jan J Weening, Madelon van Agteren, Frank J M F Dor (2012) <i>Kidney Int</i> <i></i> <i></i> 81: 4 <br/>

http://publicationslist.org/frank.dor/refid49 2012-02-10T21:42:32Z

Klop KW, Karatepe O, Weening JJ, van Agteren M, Dor FJ. (2012) <i>Kidney Int. </i> 81: 4 420<br/>

http://publicationslist.org/frank.dor/refid55 2012-06-17T15:23:56Z

Mesenchymal stem cells are a potential therapeutic agent in renal disease and kidney transplantation. Autologous cell use in kidney transplantation is preferred to avoid anti-HLA reactivity; however, the influence of renal disease on mesenchymal stem cells is unknown. To investigate the feasibility of autologous cell therapy in patients with renal disease, we isolated these cells from subcutaneous...<br/><br/>Marieke Roemeling-van Rhijn, Marlies E J Reinders, Annelies de Klein, Hannie Douben, Sander S Korevaar, Fane K F Mensah, Frank J M F Dor, Jan N M Ijzermans, Michiel G H Betjes, Carla C Baan, Willem Weimar, Martin J Hoogduijn (2012) <i>Kidney Int</i> <i></i> <i></i> : <br/>

http://publicationslist.org/frank.dor/refid54 2012-05-27T22:25:38Z

Experimental studies have established the use of mesenchymal stem cells (MSC) as a candidate immunosuppressive therapy. MSC exert their immunomodulatory function through the inhibition of CD4(+) and CD8(+) T cell proliferation. It is unknown whether MSC impair the immunosuppressive function of regulatory T cells (Treg). In vitro and in vivo studies suggest that MSC mediate their immunomodulatory e...<br/><br/>Anja U Engela, Carla C Baan, Frank J M F Dor, Willem Weimar, Martin J Hoogduijn (2012) <i>Front Immunol</i> <i></i> <i></i> 3: <br/>

http://publicationslist.org/frank.dor/refid45 2011-04-26T19:06:48Z

In the literature, varying terminology for living organ donation can be found. However, there seems to be a need for a new classification to avoid confusion. Therefore, we assessed existing terminology in the light of current living organ donation practices and suggest a more straightforward classification. We propose to concentrate on the degree of specificity with which donors identify intended ...<br/><br/>Frank J M F Dor, Emma K Massey, Mihaela Frunza, Rachel Johnson, Annette Lennerling, Charlotte Lovén, Nizam Mamode, Assya Pascalev, Sigrid Sterckx, Kristof Van Assche, Willij C Zuidema, Willem Weimar (2011) <i>Transplantation</i> <i></i> <i></i> 91: 9 935-938<br/>

http://publicationslist.org/frank.dor/refid48 2012-05-23T11:36:00Z

Gijs Elshout, Frank J M F Dor, Leon C Verhoog, Luuk Berk, Wietske W Vrijland (2011) <i>Gut</i> <i></i> <i></i> 60: 9 <br/>

http://publicationslist.org/frank.dor/refid53 2012-05-23T11:36:46Z

Martin J Hoogduijn, Frank JMF Dor (2011) <i>Front Immunol</i> <i></i> <i></i> 2: <br/>

http://publicationslist.org/frank.dor/refid50 2012-02-10T21:45:40Z

ABSTRACT: BACKGROUND: Peritoneal dialysis (PD) is an effective treatment for end-stage renal disease. It allows patients more freedom to perform daily activities compared to haemodialysis. Key to successful PD is the presence of a well-functioning dialysis catheter. Several complications, such as in- and outflow obstruction, peritonitis, exit-site infections, leakage and migration, can lead to...<br/><br/>Hagen SM, van Alphen AM, IJzermans JN, Dor FJ. (2011) <i>BMC Surg</i> 20: 11 35<br/>

http://publicationslist.org/frank.dor/refid52 2012-05-23T11:36:00Z

Peritoneal dialysis (PD) is an effective treatment for end-stage renal disease. It allows patients more freedom to perform daily activities compared to haemodialysis. Key to successful PD is the presence of a well-functioning dialysis catheter. Several complications, such as in- and outflow obstruction, peritonitis, exit-site infections, leakage and migration, can lead to catheter removal and loss...<br/><br/>Sander M Hagen, Arjan M van Alphen, Jan N M Ijzermans, Frank J M F Dor (2011) <i>BMC Surg</i> <i></i> <i></i> 11: <br/>

http://publicationslist.org/frank.dor/refid46 2011-04-26T19:06:48Z

Frank J M F Dor, Mario-Luis Ramirez, Julian D Down, David K C Cooper (2010) <i>Transplantation</i> <i></i> <i></i> 90: 9 1040-1; author reply 1041-2<br/>

http://publicationslist.org/frank.dor/refid47 2011-04-26T19:06:48Z

There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying th...<br/><br/>Martin J Hoogduijn, Felix C Popp, Anja Grohnert, Meindert J Crop, Marieke van Rhijn, Ajda T Rowshani, Elke Eggenhofer, Philipp Renner, Marlies E Reinders, Ton J Rabelink, Luc J W van der Laan, Frank J M F Dor, Jan N M Ijzermans, Paul G Genever, Claudia Lange, Antoine Durrbach, Jaco H Houtgraaf, Bruno Christ, Martina Seifert, Murat Shagidulin, Vincent Donckier, Robert Deans, Olle Ringden, Norberto Perico, Giuseppe Remuzzi, Amelia Bartholomew, Hans J Schlitt, Willem Weimar, Carla C Baan, Marc H Dahlke (2010) <i>Transplantation</i> <i></i> <i></i> 90: 2 124-126<br/>

http://publicationslist.org/frank.dor/refid3 2011-04-26T19:06:48Z

To avoid hyperacute rejection of xeno-organs, alpha1,3-galactosyltransferase knock-out (GalT-KO) pigs have been produced. However, Galalpha1,3Gal (Gal) determinant elimination may expose cryptic carbohydrate antigens and/or generate new antigens that might interfere with the human immune response.<br/><br/>M Diswall, J Angström, H-J Schuurman, F J M F Dor, L Rydberg, M E Breimer (2008) <i>Transplant Proc</i> <i></i> <i></i> 40: 2 543-546<br/>

http://publicationslist.org/frank.dor/refid1 2011-04-26T19:06:48Z

The use of alpha1,3-galactosyltransferase gene-knockout (GalT-KO) swine donors in discordant xenotransplantation has extended the survival of cardiac xenografts in baboons following transplantation. Eight baboons received heterotopic cardiac xenografts from GalT-KO swine and were treated with a chronic immunosuppressive regimen. The pathologic features of acute humoral xenograft rejection (AHXR), ...<br/><br/>Y Hisashi, K Yamada, K Kuwaki, Y-L Tseng, F J M F Dor, S L Houser, S C Robson, H-J Schuurman, D K C Cooper, D H Sachs, R B Colvin, A Shimizu (2008) <i>Am J Transplant</i> <i></i> <i></i> 8: 12 2516-2526<br/>

http://publicationslist.org/frank.dor/refid2 2011-04-26T19:06:48Z

Heterotopic cardiac xenotransplantation from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) swine to baboons was performed to characterize immunological reaction to the xenograft in the absence of anti-Gal antibody-mediated rejection. Eight baboons received heterotopic cardiac xenografts from GalT-KO porcine donors. All baboons were treated with chronic immunosuppressive therapy. Both hist...<br/><br/>Akira Shimizu, Yosuke Hisashi, Kenji Kuwaki, Yau-Lin Tseng, Frank J M F Dor, Stuart L Houser, Simon C Robson, Henk-Jan Schuurman, David K C Cooper, David H Sachs, Kazuhiko Yamada, Robert B Colvin (2008) <i>Am J Pathol</i> <i></i> <i></i> 172: 6 1471-1481<br/>

http://publicationslist.org/frank.dor/refid5 2011-04-26T19:06:48Z

The major developments in pig-to-non-human primate heart xenotransplantation during the past 20 years are summarized, largely through the experience of one investigator. Genetic modifications to organ-source pigs have been important steps in increasing heart xenograft survival from a few minutes in 1986 to 2 to 6 months in 2005.<br/><br/>Xiaocheng Zhu, Frank J M F Dor, David K C Cooper (2007) <i>J Heart Lung Transplant</i> <i></i> <i></i> 26: 3 210-218<br/>

http://publicationslist.org/frank.dor/refid6 2011-04-26T19:06:48Z

Porcine lymphotropic herpesvirus-1 (PLHV-1) is a gamma-herpesvirus related to Epstein-Barr virus (EBV) and associated with development of posttransplant lymphoproliferative disorder (PTLD) following allogeneic stem cell or spleen transplantation in miniature swine. Oligonucleotide microarrays were designed based on known open reading frames (ORFs) of PLHV-1. Expression was compared by cohybridizat...<br/><br/>Karen Doucette, Frank J M F Dor, Robert A Wilkinson, Stanley I Martin, Christene A Huang, David K C Cooper, David H Sachs, Jay A Fishman (2007) <i>Transplantation</i> <i></i> <i></i> 83: 1 87-90<br/>

http://publicationslist.org/frank.dor/refid4 2011-04-26T19:06:48Z

To avoid hyperacute rejection of xeno-organs, alpha1,3-galactosyltransferase knockout (GalT-KO) pigs have been produced. Galalpha1,3Gal determinant elimination may expose cryptic carbohydrate antigens and/or generate new antigens. This is the first biochemical study of carbohydrate antigens in GalT-KO pig organs.<br/><br/>Mette Diswall, Jonas Angström, Henk-Jan Schuurman, Frank J M F Dor, Lennart Rydberg, Michael E Breimer (2007) <i>Transplantation</i> <i></i> <i></i> 84: 10 1348-1356<br/>

http://publicationslist.org/frank.dor/refid11 2009-01-05T22:47:40Z

BACKGROUND: This study investigates anti-nonGal antibodies (Abs) in baboons after alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pig heart transplantation (Tx). METHODS: Four baboons underwent pig heart Tx under chronic immunosuppression, which was discontinued after graftectomy. During follow-up, one baboon also received a pig splenocyte infusion. Hearts and splenocytes were from GalT-KO ...<br/><br/>Yau-Lin Tseng, Kathleen Moran, Frank J M F Dor, Todd M Sanderson, Wei Li, Courtney J Lancos, Henk-Jan Schuurman, David H Sachs, David K C Cooper (2006) <i>Transplantation</i> <i></i> <i></i> 81: 7 1058-1062<br/>

http://publicationslist.org/frank.dor/refid9 2009-01-05T22:46:33Z

Frank J M F Dor, David K C Cooper (2006) <i>Transpl Immunol</i> <i></i> <i></i> 16: 2 <br/>

http://publicationslist.org/frank.dor/refid10 2009-01-05T22:46:33Z

Frank J M F Dor, David K C Cooper (2006) <i>Ann Surg</i> <i></i> <i></i> 243: 5 710-711<br/>

http://publicationslist.org/frank.dor/refid8 2009-01-05T22:46:33Z

BACKGROUND: The recent availability of alpha1,3-galactosyltransferase knockout (GalT-KO) miniature swine has eliminated anti-Gal antibodies as the major barrier to xenotransplantation, potentially bringing this modality closer to clinical application. Highly-allosensitized patients, who have poor prospects of receiving a suitable cross-match negative human organ, might be the first patients to ben...<br/><br/>Banny S Wong, Kazuhiko Yamada, Masayoshi Okumi, Joshua Weiner, Patricia E O'Malley, Yau-Lin Tseng, Frank J M F Dor, David K C Cooper, Susan L Saidman, Adam Griesemer, David H Sachs (2006) <i>Transplantation</i> <i></i> <i></i> 82: 3 314-319<br/>

http://publicationslist.org/frank.dor/refid7 2009-01-05T22:46:33Z

OBJECTIVE: We previously observed high levels (>40%) of multilineage hematopoietic cell chimerism following spleen transplantation across full MHC barriers in immunosuppressed miniature swine. We therefore investigated the spleen as a source of hematopoietic progenitor cells (HPCs). MATERIALS AND METHODS: Specific cell-surface markers were used to identify HPCs in the spleen and bone marrow (BM) o...<br/><br/>Frank J M F Dor, Mario L Ramirez, Kalindi Parmar, Erica L Altman, Christene A Huang, Julian D Down, David K C Cooper (2006) <i>Exp Hematol</i> <i></i> <i></i> 34: 11 1573-1582<br/>

http://publicationslist.org/frank.dor/refid17 2009-01-05T22:47:40Z

Spleen transplantation (SpTx) has established donor-specific tolerance in rodents, but not in large animals or humans. We report the histopathology of rejection in an established model of SpTx in major histocompatibility complex (MHC)-defined miniature swine. Of the 17 SpTx, rejection was observed in two grafts transplanted into untreated, MHC-matched, minor antigen-disparate recipients (group 1, ...<br/><br/>Frank J M F Dor, Bernd Gollackner, Kenji Kuwaki, Dicken S C Ko, David K C Cooper, Stuart L Houser (2005) <i>Int J Exp Pathol</i> <i></i> <i></i> 86: 1 57-66<br/>

http://publicationslist.org/frank.dor/refid18 2009-01-05T22:47:40Z

Troponin T levels have been monitored in baboons (n = 8) undergoing pig heterotopic heart transplantation, and correlated with a decrease in graft contractions and graft survival. Pig heart graft survival was from 12 to 139 days (mean 45, median 33), and graft failure was associated with predominant thrombotic microangiopathy and ischemia, with focal hemorrhage, and edema. An increase in troponin ...<br/><br/>K Kuwaki, C Knosalla, F J M F Dor, B Gollackner, Y-L Tseng, S Houser, D K C Cooper (2005) <i>J Heart Lung Transplant</i> <i></i> <i></i> 24: 1 92-94<br/>

http://publicationslist.org/frank.dor/refid21 2009-01-05T22:48:06Z

BACKGROUND: Xenotransplantation using pigs as source species carries a risk for the activation of latent herpesviruses from the porcine donor and potential transmission to the recipient. In pig-to-baboon xenotransplantation, activation of porcine cytomegalovirus (PCMV) has been associated with xenograft injury and an increased incidence of consumptive coagulopathy and graft loss. Activation of por...<br/><br/>Nicolas J Mueller, Kenji Kuwaki, Christoph Knosalla, Frank J M F Dor, Bernd Gollackner, Robert A Wilkinson, Scott Arn, David H Sachs, David K C Cooper, Jay A Fishman (2005) <i>Xenotransplantation</i> <i></i> <i></i> 12: 1 59-62<br/>

http://publicationslist.org/frank.dor/refid19 2009-01-05T22:47:40Z

Hearts from alpha1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody-based regimen. The elimination of the galactose-alpha1,3-galactose epitope prevented hyperacute rejection and extended survival of pig hearts in baboons for 2-6 months (median, 78 d); the predominant lesion associated with graft failure wa...<br/><br/>Kenji Kuwaki, Yau-Lin Tseng, Frank J M F Dor, Akira Shimizu, Stuart L Houser, Todd M Sanderson, Courtney J Lancos, Derek D Prabharasuth, Jane Cheng, Kathleen Moran, Yosuke Hisashi, Nicolas Mueller, Kazuhiko Yamada, Julia L Greenstein, Robert J Hawley, Clive Patience, Michel Awwad, Jay A Fishman, Simon C Robson, Henk-Jan Schuurman, David H Sachs, David K C Cooper (2005) <i>Nat Med</i> <i></i> <i></i> 11: 1 29-31<br/>

http://publicationslist.org/frank.dor/refid14 2009-01-05T22:47:40Z

The adult spleen is a source of early hematopoietic stem cells (HSC). We therefore studied whether culturing spleen or bone marrow (BM) HSC in medium containing 5-azacytidine could induce a cardiac phenotype. c-kit enrichment and depletion of adult pig spleen and BM mononuclear cells were obtained by magnetic bead separation using biotinylated pig stem cell factor (c-kit ligand). Cells were incuba...<br/><br/>M L Ramirez, I M McMorrow, T M Sanderson, C J Lancos, Y-L Tseng, D K C Cooper, F J M F Dor (2005) <i>Cells Tissues Organs</i> <i></i> <i></i> 180: 4 195-203<br/>

http://publicationslist.org/frank.dor/refid13 2009-01-05T22:47:40Z

BACKGROUND: The recent generation of alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs has allowed investigation of the survival of GalT-KO pig organs in nonhuman primates. METHODS: Heterotopic heart transplantation from GalT-KO pigs was carried out in baboons (n=8) using a human antihuman CD154 monoclonal antibody-based immunosuppressive regimen. RESULTS: In six of the eight cases, graf...<br/><br/>Yau-Lin Tseng, Kenji Kuwaki, Frank J M F Dor, Akira Shimizu, Stuart Houser, Yosuke Hisashi, Kazuhiko Yamada, Simon C Robson, Michel Awwad, Henk-Jan Schuurman, David H Sachs, David K C Cooper (2005) <i>Transplantation</i> <i></i> <i></i> 80: 10 1493-1500<br/>

http://publicationslist.org/frank.dor/refid16 2009-01-05T22:47:40Z

Hearts from alpha1,3-Galactosyltransferase gene-knockout (GaIT-KO) pigs were transplanted heterotopically into 8 baboons that received an anti-CD154 monoclonal antibody (mAb)-based immunosuppressive regimen and heparin. Three baboons died or were euthanized with beating grafts on 16, 23, and 56 days, respectively, and the remaining 5 grafts functioned for 59-179 days. Hyperacute rejection did not ...<br/><br/>F J M F Dor, K Kuwaki, Y-L Tseng, A Shimizu, S L Houser, K Yamada, R J Hawley, C Patience, M Awwad, J A Fishman, S C Robson, D H Sachs, H-J Schuurman, D K C Cooper (2005) <i>Transplant Proc</i> <i></i> <i></i> 37: 1 489-490<br/>

http://publicationslist.org/frank.dor/refid15 2009-01-05T22:47:40Z

K Kuwaki, Y-L Tseng, F J M F Dor, A Shimizu, D H Sachs, D K C Cooper (2005) <i>Xenotransplantation</i> <i></i> <i></i> 12: 6 489-491<br/>

http://publicationslist.org/frank.dor/refid12 2009-01-05T22:47:40Z

BACKGROUND: In rodents, spleen allotransplantation (SpTx) induces tolerance. We investigated the induction of chimerism and donor-specific unresponsiveness following pig SpTx. METHODS: Thirteen pigs underwent splenectomy (day 0); all received a blood transfusion. In 11/13 pigs, SpTx was performed across a MHC class I (n=1) or full (n=10) barrier; two control pigs received no SpTx. All pigs were mo...<br/><br/>Frank J M F Dor, Yau-Lin Tseng, Kenji Kuwaki, Bernd Gollackner, Mario L Ramirez, Derek D Prabharasuth, Robert A Cina, Christoph Knosalla, Matthew G Nuhn, Stuart L Houser, Christene A Huang, Dicken S C Ko, David K C Cooper (2005) <i>Transplantation</i> <i></i> <i></i> 80: 12 1791-1804<br/>

http://publicationslist.org/frank.dor/refid22 2009-01-05T22:48:06Z

BACKGROUND: Acute humoral xenograft rejection (AHXR) is an immunologic barrier in pig-to-baboon organ transplantation (Tx). We report microvascular thrombosis and myocardial necrosis in a series of cardiac xenografts. METHODS: Ten baboons underwent heterotopic heart Tx from pigs transgenic for human decay-accelerating factor. Recipients were treated with soluble Gal glycoconjugates and multiple im...<br/><br/>Stuart L Houser, Kenji Kuwaki, Christoph Knosalla, Frank J M F Dor, Bernd Gollackner, Jane Cheng, Akira Shimizu, Henk-Jan Schuurman, David K C Cooper (2004) <i>Xenotransplantation</i> <i></i> <i></i> 11: 5 416-425<br/>

http://publicationslist.org/frank.dor/refid20 2009-01-05T22:47:40Z

BACKGROUND: Xenotransplantation using pigs as the source species for organs carries a potential risk for transmission and activation of porcine herpesviruses. Activation of porcine cytomegalovirus (PCMV) in pig-to-baboon xenotransplantation is associated with xenograft injury and possibly an increased incidence of consumptive coagulopathy (CC). METHODS: To further investigate the role of PCMV acti...<br/><br/>Nicolas J Mueller, Kenji Kuwaki, Frank J M F Dor, Christoph Knosalla, Bernd Gollackner, Robert A Wilkinson, David H Sachs, David K C Cooper, Jay A Fishman (2004) <i>Transplantation</i> <i></i> <i></i> 78: 10 1449-1453<br/>

http://publicationslist.org/frank.dor/refid28 2009-01-05T22:48:06Z

Tissue-invasive disease due to porcine cytomegalovirus (PCMV) has been demonstrated after pig-to-baboon solid-organ xenotransplantation. Porcine lymphotropic herpesvirus (PLHV)-1 is associated with B cell proliferation and posttransplant lymphoproliferative disorder after allogeneic bone marrow transplantation in swine but has not been observed in pig-to-primate xenotransplantation. Activation of ...<br/><br/>Nicolas J Mueller, Christine Livingston, Christoph Knosalla, Rolf N Barth, Shin Yamamoto, Bernd Gollackner, Frank J M F Dor, Leo Buhler, David H Sachs, Kazuhiko Yamada, David K C Cooper, Jay A Fishman (2004) <i>J Infect Dis</i> <i></i> <i></i> 189: 9 1628-1633<br/>

http://publicationslist.org/frank.dor/refid31 2009-01-05T22:48:33Z

Gal alpha 1,3Gal (Gal) is the first target in antibody-mediated rejection of pig-to-non-human primate xenograft. Its expression may vary between organs and constituents of organs. Gal expression was studied in pancreas, testis, spleen and thymus of 22 pigs, with ages ranging from 1 to 22 months. The immunoperoxidase technique using the biotinylated lectin, Griffonia simplicifolia (IB4), was used. ...<br/><br/>F J M F Dor, J Cheng, A Alt, D K C Cooper, H-J Schuurman (2004) <i>Xenotransplantation</i> <i></i> <i></i> 11: 1 101-106<br/>

http://publicationslist.org/frank.dor/refid32 2009-01-05T22:48:33Z

AIM: to study whether sensitization to pig antigens results in humoral and/or cellular sensitization to alloantigens in baboons, and thus increases the risks of organ allotransplantation after xenotransplantation. Serum from baboons that were naive (n = 4), sensitized to Gal alpha 1,3Gal (Gal) antigens (n = 2), or sensitized to Gal + non-Gal pig antigens (n = 2) were tested by flow cytometry for t...<br/><br/>R M Baertschiger, F J M F Dor, D Prabharasuth, K Kuwaki, D K C Cooper (2004) <i>Xenotransplantation</i> <i></i> <i></i> 11: 1 27-32<br/>

http://publicationslist.org/frank.dor/refid33 2009-01-05T22:48:33Z

There is a shortage of human blood for transfusion. The possibility of using alpha-galactosidase-treated pig red blood cells (pRBCs) for transfusion into humans has been investigated. pRBCs were treated in vitro with alpha-galactosidase. In vitro binding of antibodies (Abs) in baboon or human sera to untreated/treated pRBCs was assessed by flow cytometry and serum cytotoxicity. In vivo clearance r...<br/><br/>Jan M Eckermann, Leo H Buhler, Alex Zhu, Frank J M F Dor, Michel Awwad, David K C Cooper (2004) <i>Xenotransplantation</i> <i></i> <i></i> 11: 1 18-26<br/>

http://publicationslist.org/frank.dor/refid23 2009-01-05T22:48:06Z

Spleen transplantation (SpTx) was performed in miniature swine across full major histocompatibility complex barriers to study the tolerogenic effect of the spleen. This study describes the development of posttransplant lymphoproliferative disease (PTLD) after allogeneic SpTx. Recipient pigs underwent whole body irradiation (100 cGy), thymic irradiation (700 cGy), and native splenectomy (day 0), an...<br/><br/>Frank J M F Dor, Karen E Doucette, Nicolas J Mueller, Robert A Wilkinson, Junaid A Bajwa, Isabel M McMorrow, Yau-Lin Tseng, Kenji Kuwaki, Stuart L Houser, Jay A Fishman, David K C Cooper, Christene A Huang (2004) <i>Transplantation</i> <i></i> <i></i> 78: 2 286-291<br/>

http://publicationslist.org/frank.dor/refid30 2009-01-05T22:48:06Z

F J M F Dor, F J Rouhani, D K C Cooper (2004) <i>Xenotransplantation</i> <i></i> <i></i> 11: 3 295-297<br/>

http://publicationslist.org/frank.dor/refid34 2009-01-05T22:48:33Z

Natural and elicited antipig antibodies (Abs) lead to acute humoral xenograft rejection (AHXR). Ten baboons underwent heterotopic heart transplantation (Tx) from human decay-accelerating factor (hDAF) pigs. Depletion of anti-Galalpha1, 3Gal (Gal) Abs was achieved by the infusion of a Gal glycoconjugate from day-1. Immunosuppression included induction of antithymocyte globulin, thymic irradiation, ...<br/><br/>Kenji Kuwaki, Christoph Knosalla, Frank J M F Dor, Bernd Gollackner, Yau-Lin Tseng, Stuart Houser, Nicolas Mueller, Derek Prabharasuth, Amy Alt, Kathy Moran, Jane Cheng, Amir Behdad, David H Sachs, Jay A Fishman, Henk-Jan Schuurman, Michel Awwad, David K C Cooper (2004) <i>Am J Transplant</i> <i></i> <i></i> 4: 3 363-372<br/>

http://publicationslist.org/frank.dor/refid24 2009-01-05T22:48:06Z

BACKGROUND: The expression of galactose alpha 1,3 galactose (Gal) in pigs has proved a barrier to xenotransplantation. Miniature swine lacking Gal (Gal pigs) have been produced by nuclear transfer/embryo transfer. METHODS: The tissues of five Gal pigs of SLA dd haplotype (SLA) were tested for the presence of Gal epitopes by staining with the Griffonia simplicifolia IB4 lectin. Their sera were test...<br/><br/>Frank J M F Dor, Yau-Lin Tseng, Jane Cheng, Kathleen Moran, Todd M Sanderson, Courtney J Lancos, Akira Shimizu, Kazuhiko Yamada, Michel Awwad, David H Sachs, Robert J Hawley, Henk-Jan Schuurman, David K C Cooper (2004) <i>Transplantation</i> <i></i> <i></i> 78: 1 15-20<br/>

http://publicationslist.org/frank.dor/refid25 2009-01-05T22:48:06Z

BACKGROUND: Pigs are a potential source of red blood cells (RBCs) for transfusion into humans, but the presence of galactose-alpha1,3-galactose (Gal) epitopes on their surface, against which humans have anti-Gal, has been perceived as a major barrier. alpha1,3-Galactosyltransferase gene-knockout pigs, which do not express Gal epitopes on RBCs (Gal-/-), have recently become available. STUDY DESIGN ...<br/><br/>Foad J Rouhani, Frank J M F Dor, David K C Cooper (2004) <i>Transfusion</i> <i></i> <i></i> 44: 7 1004-1012<br/>

http://publicationslist.org/frank.dor/refid26 2009-01-05T22:48:06Z

F J M F Dor, D K C Cooper (2004) <i>Xenotransplantation</i> <i></i> <i></i> 11: 4 <br/>

http://publicationslist.org/frank.dor/refid29 2009-01-05T22:48:06Z

F J M F Dor, Y-L Tseng, K Kuwaki, D S C Ko, D K C Cooper (2004) <i>Xenotransplantation</i> <i></i> <i></i> 11: 3 298-300<br/>

http://publicationslist.org/frank.dor/refid27 2009-01-05T22:48:06Z

BACKGROUND: Successful hematopoietic cell allotransplantation results in donor-specific tolerance, but this approach has been unsuccessful in the wild-type pig-to-baboon xenotransplantation model, as pig cells were lost from the circulation within 5 days. However, after cessation of immunosuppressive therapy on day 28, all baboons demonstrated non-specific unresponsiveness on mixed leukocyte react...<br/><br/>Y-L Tseng, F J M F Dor, K Kuwaki, D Ryan, J Wood, M Denaro, M Giovino, K Yamada, R Hawley, C Patience, H-J Schuurman, M Awwad, D H Sachs, D K C Cooper (2004) <i>Xenotransplantation</i> <i></i> <i></i> 11: 4 361-370<br/>

http://publicationslist.org/frank.dor/refid39 2009-01-05T22:48:33Z

C Knosalla, K Teranishi, B Gollackner, F J M F Dor, D K C Cooper (2003) <i>Xenotransplantation</i> <i></i> <i></i> 10: 2 187-188<br/>

http://publicationslist.org/frank.dor/refid37 2009-01-05T22:48:33Z

BACKGROUND: Spleen transplantation (Tx) between some strains of rodents can lead to donor-specific tolerance either spontaneously or after a short course of immunosuppression. This study developed a surgical technique for spleen Tx in miniature swine to investigate its immunologic impact in a large animal model. METHODS: The preferred surgical technique of spleen Tx (n=8) involved excision of the ...<br/><br/>B Gollackner, F J M F Dor, C Knosalla, L Buhler, M Duggan, C A Huang, S L Houser, D H Sachs, T Kawai, D S C Ko, D K C Cooper (2003) <i>Transplantation</i> <i></i> <i></i> 75: 11 1799-1806<br/>

http://publicationslist.org/frank.dor/refid36 2009-01-05T22:48:33Z

BACKGROUND: A rapidly progressive disorder termed consumptive coagulopathy (CC) has been observed frequently in pig-to-baboon renal xenotransplantation. CC may be initiated by endothelial activation and induction of procoagulant factors after immunologic injury or infection, or by molecular incompatibilities between porcine coagulation proteins and primate clotting factors. The activation of porci...<br/><br/>Bernd Gollackner, Nicolas J Mueller, Stuart Houser, Imrana Qawi, Daniel Soizic, Christoph Knosalla, Leo Buhler, Frank J M F Dor, Michel Awwad, David H Sachs, David K C Cooper, Simon C Robson, Jay A Fishman (2003) <i>Transplantation</i> <i></i> <i></i> 75: 11 1841-1847<br/>

http://publicationslist.org/frank.dor/refid35 2009-01-05T22:48:33Z

In some rodent strain combinations, allogeneic spleen transplantation induces tolerance spontaneously to itself and to other donor-specific organs. In other combinations, a state of tolerance has been achieved in the weakened immune system of the recipient. The data indicate that if a balance can be achieved between host-versus-graft and graft-versus-host responses, tolerance develops, possibly du...<br/><br/>Frank J M F Dor, Bernd Gollackner, David K C Cooper (2003) <i>Transpl Int</i> <i></i> <i></i> 16: 7 451-460<br/>

http://publicationslist.org/frank.dor/refid40 2009-01-05T22:48:33Z

BACKGROUND AND AIMS OF THE STUDY: Human valve allografts are commonly used in cardiac surgery for congenital and acquired valve diseases. Particularly in the pediatric population, these allografts are prone to fail in the long term, and require replacement. In part, this failure may be due to immunological phenomena. The frequency of helper T lymphocytes (HTLf) measured in peripheral blood and spl...<br/><br/>Frank J M F Dor, Frans B S Oei, Leonard M B Vaessen, Richard L Marquet, Ad J J C Bogers, Willem Weimar (2002) <i>J Heart Valve Dis</i> <i></i> <i></i> 11: 3 326-334<br/>

http://publicationslist.org/frank.dor/refid38 2009-01-05T22:48:33Z

Xenotransplantation, involving the transplantation of pig organs into humans, would resolve the current shortage of organs. It involves, however, a new therapeutic approach to organ transplantation. The presence of natural antibody in primates directed against Galalpha1,3Gal epitopes on pig vascular endothelium leads to early antibody-mediated rejection. An elicited antibody response against the s...<br/><br/>C Knosalla, B Gollackner, F J M F Dor, D K C Cooper (2002) <i>Curr Drug Targets Cardiovasc Haematol Disord</i> <i></i> <i></i> 2: 2 105-119<br/>

http://publicationslist.org/frank.dor/refid41 2009-01-05T22:50:33Z

F Oei, F Dor, A Stegmann, M Welters, L Vaessen, R Marquet, A Bogers, W Weimar (2001) <i>Transplant Proc</i> 33: 1-2 640-641<br/>

http://publicationslist.org/frank.dor/refid44 2009-01-06T00:37:11Z

F.J.M.F. Dor, F.B.S. Oei, M.J.P. Welters, L.M.B. Vaessen, R.L. Marquet, A.J.J.C. Bogers, W. Weimar. (2000) <i>Nederlands Tijdschrift voor Geneeskunde-studenteneditie </i> 3: 4 61-65<br/>

http://publicationslist.org/frank.dor/refid42 2009-01-06T00:33:16Z

F.J.M.F. Dor, G. de Jong, H.G. van Eijk. (1998) <i>Nederlands Tijdschrift voor Klinische Chemie </i> 23: 1 24-26<br/>

http://publicationslist.org/frank.dor/refid43 2009-01-06T00:35:02Z

F.J.M.F. Dor, M.I. Cleton, G. de Jong, H.G. van Eijk. (1998) <i>Biochemical Education</i> 26: 317-319<br/>