http://publicationslist.org/data/frantisek.saudek/atom.xml Frantisek Saudekhttp://publicationslist.org/frantisek.saudek$basepathfavicon.icoRecent additions to Frantisek Saudek's PublicationsList.org pagehttp://publicationslist.org/publications.png2008-07-09T11:06:02Z http://publicationslist.org/frantisek.saudek/refid5 2008-07-09T10:54:40Z

Adult pancreatic stem and progenitor cells could represent an alternative source of insulin-producing tissue for diabetes treatment. In order to identify these cells, we have focused on the human pancreatic cells expressing cell surface molecule CD133, a marker of adult stem cells. We found that population of human CD133-positive pancreatic cells contains endocrine progenitors expressing neurogeni...<br/><br/>T Koblas, L Pektorova, K Zacharovova, Z Berkova, P Girman, E Dovolilova, L Karasova, F Saudek (2008) <i>Transplant Proc</i> <i></i> <i></i> 40: 2 415-418<br/>

http://publicationslist.org/frantisek.saudek/refid6 2008-07-09T10:54:40Z

There is a crucial need for noninvasive assessment tools after cell transplantation. This study investigates whether a magnetic resonance imaging (MRI) strategy could be clinically applied to islet transplantation. The purest fractions of seven human islet preparations were labeled with superparamagnetic iron oxide particles (SPIO, 280 microg/mL) and transplanted into four patients with type 1 dia...<br/><br/>C Toso, J-P Vallee, P Morel, F Ris, S Demuylder-Mischler, M Lepetit-Coiffe, N Marangon, F Saudek, A M James Shapiro, D Bosco, T Berney (2008) <i>Am J Transplant</i> <i></i> <i></i> 8: 3 701-706<br/>

http://publicationslist.org/frantisek.saudek/refid7 2008-07-09T10:54:40Z

Increased ATP/ADP ratio resulting from enhanced glycolysis and oxidative phosphorylation represents a plausible mechanism controlling the glucose-stimulated insulin secretion (GSIS) in pancreatic beta-cells. Although specific bioenergetics might be involved, parallel studies of cell respiration and mitochondrial membrane potential (DeltaPsi(m)) during GSIS are lacking. Using high resolution respir...<br/><br/>Tomás Spacek, Jitka Santorová, Klára Zacharovová, Zuzana Berková, Lydie Hlavatá, Frantisek Saudek, Petr Jezek (2008) <i>Int J Biochem Cell Biol</i> <i></i> <i></i> 40: 8 1522-1535<br/>

http://publicationslist.org/frantisek.saudek/refid4 2008-07-09T10:54:40Z

Objective: To assess the effect of normoglycemia following simultaneous pancreas/kidney transplantation (SPK) on neurological function and intraepidermal nerve fiber density (IENFD) in patients with type 1 (DM). Methods: We performed vibration perception threshold (VPT) and autonomic function testing (AFT) and assessed IENFD in skin biopsies from the lower thigh and upper calf in 14 healthy contro...<br/><br/> Boucek, Havrdova, Voska, Lodererova, He, Saudek, Lipar, Adamec, Sommer (2008) <i>Diabetes Care</i> <i></i> <i></i> : <br/>

http://publicationslist.org/frantisek.saudek/refid8 2008-07-09T10:54:40Z

Polyomavirus-associated nephropathy (PVAN) has emerged as an important cause of graft loss following kidney transplantation. Experience with kidney retransplantation (reKT) in PVAN is very limited, especially in the setting of uninterrupted immunosuppression protecting the still functioning pancreatic graft after simultaneous pancreas/kidney transplantation (SPK). We present a review of five cases...<br/><br/>Martina Mindlova, Petr Boucek, Frantisek Saudek, Teodora Jedinakova, Ludek Voska, Eva Honsova, Kvetoslav Lipar, Milos Adamec, Hans H Hirsch (2008) <i>Transpl Int</i> <i></i> <i></i> 21: 4 353-356<br/>

http://publicationslist.org/frantisek.saudek/refid1 2008-07-09T10:54:40Z

In vitro labeling of pancreatic islets with iron nanoparticles enables their direct posttransplant visualization by magnetic resonance; however, there is still a discrepancy in the fate of iron nanoparticles. This study was performed to detail the labeling process, consequently to improve the labeling efficacy and to confirm safety for islet cells. The islets were visible on T2*-weighted magnetic ...<br/><br/>Zuzana Berkova, Daniel Jirak, Klara Zacharovova, Jan Kriz, Alena Lodererova, Peter Girman, Tomas Koblas, Eva Dovolilova, Marie Vancova, Milan Hajek, Frantisek Saudek (2008) <i>Transplantation</i> <i></i> <i></i> 85: 1 155-159<br/>

http://publicationslist.org/frantisek.saudek/refid2 2008-07-09T10:54:40Z

AIM: Assessment of islet mass before islet transplantation requires a reliable technique to enable exact analysis of islet volume. This study aimed to test the applicability of digital image analysis (DIA) for evaluation of samples of purified and non-purified islets. METHODS: Pancreatic islets were isolated from 10 Lewis rats. Samples of purified (n = 10) and non-purified islets (n = 30) were cou...<br/><br/>Peter Girman, Zuzana Berkova, Eva Dobolilova, Frantisek Saudek (2008) <i>Rev Diabet Stud</i> <i></i> <i></i> 5: 1 38-46<br/>

http://publicationslist.org/frantisek.saudek/refid3 2008-07-09T10:54:40Z

Diabetes is a disorder characterized by beta-cell loss or exhaustion and insulin deficiency. At present, knowledge is lacking on the underlying causes and for the therapeutic recovery of the beta-cell mass. A better understanding of diabetes pathogenesis could be obtained through exact monitoring of the fate of beta-cells under disease and therapy conditions. This could pave the way for a new era ...<br/><br/>Frantisek Saudek, Carl-Henrik Brogren, Srirang Manohar (2008) <i>Rev Diabet Stud</i> <i></i> <i></i> 5: 1 6-12<br/>

http://publicationslist.org/frantisek.saudek/refid13 2008-07-09T10:56:53Z

The existence of an adult PSC that may be used in the treatment of diabetes is still a matter of scientific debate as conclusive evidence of such a stem cell in the adult pancreas has not yet been presented. The main reason why putative PSC has not yet been identified is the lack of specific markers that may be used to isolate and purify them. In order to increase the list of potential PSC markers...<br/><br/>T Koblas, K Zacharovová, Z Berková, M Mindlová, P Girman, E Dovolilová, L Karasová, F Saudek (2007) <i>Folia Biol (Praha)</i> <i></i> <i></i> 53: 1 13-22<br/>

http://publicationslist.org/frantisek.saudek/refid10 2008-07-09T10:54:40Z

Frantisek Saudek, Peter Girman, Jan Kriz, Daniel Jirak, Milan Hajek (2007) <i>Nat Med</i> <i></i> <i></i> 13: 7 <br/>

http://publicationslist.org/frantisek.saudek/refid9 2008-07-09T10:54:40Z

Diabetes mellitus continues to be the most common cause of chronic kidney failure, blindness acquired in adulthood, non-traumatic amputations and severe forms of neuropathy. Therefore it is necessary to look for new forms of therapy capable of achieving long-term normalisation of blood sugar levels. The only standard method so far is pancreas transplantation. Most often, it is performed in combina...<br/><br/>F Saudek (2007) <i>Vnitr Lek</i> <i></i> <i></i> 53: 7-8 859-864<br/>

http://publicationslist.org/frantisek.saudek/refid19 2008-07-09T10:56:53Z

In order to assess the quality of freshly isolated and cultivated pancreatic islets designed for experimental transplantation in rats we combined the vitality staining test, in vitro measurement of insulin secretion capacity, and assessment of islet respiration. Oxygen consumption was measured using the respirometer Oxygraph 2K equipped with polarographic oxygen sensors. The results of oxymetry de...<br/><br/>K Zacharovova, Z Berkova, T Spacek, J Kriz, E Dovolilova, P Girman, T Koblas, P Jezek, F Saudek (2005) <i>Transplant Proc</i> <i></i> <i></i> 37: 8 3454-3456<br/>

http://publicationslist.org/frantisek.saudek/refid18 2008-07-09T10:56:53Z

Superparamagnetic agents can be reliably used for magnetic resonance imaging (MRI) of pancreatic islets located in the liver sinusoids. However, the main disadvantages seemed to be the rather long culture time necessary for islet labeling and the low specificity of these agents. In the present study we investigated a more specific approach with a shorter labeling time using immunomagnetic particle...<br/><br/>T Koblas, P Girman, Z Berkova, D Jirak, J Kriz, E Dovolilova, K Zacharovova, M Hajek, F Saudek (2005) <i>Transplant Proc</i> <i></i> <i></i> 37: 8 3493-3495<br/>

http://publicationslist.org/frantisek.saudek/refid20 2008-07-09T10:56:53Z

OBJECTIVE: A role of autoreactive T cells for type 1 diabetes pathogenesis is considered crucial. In our pilot study we addressed if autoreactive mononuclear cells are present also in peripheral blood of patients with other specific forms of diabetes as cystic fibrosis related diabetes (CFRD). METHODS: Cellular immune responses to a known beta-cell autoantigen (GAD65 and GAD65 derived peptides) we...<br/><br/>Katerina Stechova, Stanislava Kolouskova, Zdenek Sumnik, Ondrej Cinek, Miloslav Kverka, Maria Karlsson Faresjo, Daniel Chudoba, Eva Dovolilova, Marta Pechova, Zuzana Vrabelova, Kristyna Böhmova, Lukas Janecek, Frantisek Saudek, Jan Vavrinec (2005) <i>Autoimmunity</i> <i></i> <i></i> 38: 4 319-323<br/>

http://publicationslist.org/frantisek.saudek/refid17 2008-07-09T10:56:53Z

We previously described an in vivo method for pancreatic islet visualization using magnetic resonance imaging with the aid of superparamagnetic nanoparticles of iron oxide (Resovist) or by magnetic beads precoated with antibodies (Dynabeads). The aim of this study was to investigate the in vitro effect of islet labeling on their quality. Isolated rat islets were cultivated for 48 hours with a cont...<br/><br/>Z Berkova, J Kriz, P Girman, K Zacharovova, T Koblas, E Dovolilova, F Saudek (2005) <i>Transplant Proc</i> <i></i> <i></i> 37: 8 3496-3498<br/>

http://publicationslist.org/frantisek.saudek/refid24 2008-07-09T10:57:15Z

Our study was designed to determine effect of gemcitabine on acute rejection of liver in rats. Liver transplantation was performed in rats of the Dark Agouti (DA) and Lewis (LEW) strains. Recipients were divided into three groups: A, DA-to-LEW without immunosuppression; B, DA-to-LEW, treated with cyclosporine A; C, DA-to-LEW, treated with gemcitabine. Immunosuppressants were subcutaneously injecte...<br/><br/>Hynek Mergental, Jan Kriz, Eva Honsova, Michal Kudla, Tomas Pantoflicek, Katerina Tcherentsova, Matej Kocik, Frantisek Saudek, Miroslav Ryska (2005) <i>Transpl Int</i> <i></i> <i></i> 17: 11 687-691<br/>

http://publicationslist.org/frantisek.saudek/refid22 2008-07-09T10:57:15Z

BACKGROUND: Single-centre and retrospective studies suggest superiority of tacrolimus over cyclosporin as cornerstone immunosuppressive therapy for simultaneous pancreas-kidney (SPK) transplantation. This open-label, multicentre trial compared the efficacy and safety of tacrolimus with cyclosporin microemulsion (ME) in diabetic patients with end-stage renal disease undergoing their first cadaveric...<br/><br/>Frantisek Saudek, Jacques Malaise, Petr Boucek, Milos Adamec (2005) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 20 Suppl 2: ii3-10, ii62<br/>

http://publicationslist.org/frantisek.saudek/refid21 2008-07-09T10:57:15Z

This 3-year study compared tacrolimus versus cyclosporine (CsA) microemulsion (ME) in conjunction with rATG induction, mycophenolate mofetil (MMF) and short-term corticosteroids in primary simultaneous pancreas-kidney (SPK) transplantation. PATIENTS AND METHODS: This large, prospective, multicenter study was conducted in 10 European centers and one center in Israel. Of the 205 SPK transplants perf...<br/><br/>J Malaise, F Saudek, P Boucek, M Adamec, D Van Ophem, J P Squifflet (2005) <i>Transplant Proc</i> <i></i> <i></i> 37: 6 2843-2845<br/>

http://publicationslist.org/frantisek.saudek/refid11 2008-07-09T10:56:53Z

In recent years, human umbilical cord blood (HUCB) has emerged as an attractive tool for cell-based therapy. Although at present the clinical application of HUCB is limited to the fields of hematology and oncology, a rising number of studies show potential for further application in the treatment of non-hematopoietic diseases. HUCB, with its real abundance, simple collection procedure and no serio...<br/><br/>Tomas Koblas, S Mitchell Harman, Frantisek Saudek (2005) <i>Rev Diabet Stud</i> <i></i> <i></i> 2: 4 228-234<br/>

http://publicationslist.org/frantisek.saudek/refid14 2008-07-09T10:56:53Z

BACKGROUND: We have recently described a magnetic resonance (MR) method for detection of rat pancreatic islets transplanted into the liver after labeling with superparamagnetic iron oxide nanoparticles. The aim of this work was to study whether this technique could be applicable over a longer period after transplantation and whether it could help to detect islet rejection. METHODS: Islets from Lew...<br/><br/>Jan Kriz, Daniel Jirák, Peter Girman, Zuzana Berková, Klara Zacharovova, Eva Honsova, Alena Lodererova, Milan Hajek, Frantisek Saudek (2005) <i>Transplantation</i> <i></i> <i></i> 80: 11 1596-1603<br/>

http://publicationslist.org/frantisek.saudek/refid16 2008-07-09T10:56:53Z

Metabolic effects of immunosuppressive agents are of great importance in pancreas or islet transplantation. The aim of our study was to compare effects of tacrolimus-based immunosuppression in conjunction with sirolimus (RAPA) versus mycophenolate mofetil (MMF) on glucose metabolism in type 1 diabetic recipients following a simultaneous pancreas and kidney transplantation (SPK). We examined 30 ins...<br/><br/>T Havrdova, F Saudek, P Boucek, M Adamec, R Koznarova, T Jedinakova, L Karasova, J Skibova (2005) <i>Transplant Proc</i> <i></i> <i></i> 37: 8 3544-3545<br/>

http://publicationslist.org/frantisek.saudek/refid15 2008-07-09T10:56:53Z

BACKGROUND: The minimally invasive method of skin biopsy with intraepidermal nerve fiber (IENF) counts may be used to analyze nerve regeneration in pancreas transplant (PTx) recipients. We assessed IENF counts as a database for long-term follow-up of diabetic neuropathy. METHODS: Skin biopsies were performed using a 3-mm punch from lower thigh and upper calf areas of 16 (13 pancreas/kidney, 3 panc...<br/><br/>P Boucek, T Havrdova, L Voska, A Lodererova, F Saudek, K Lipar, L Janousek, M Adamec, C Sommer (2005) <i>Transplant Proc</i> <i></i> <i></i> 37: 8 3574-3575<br/>

http://publicationslist.org/frantisek.saudek/refid27 2008-07-09T10:57:15Z

Pancreas transplantation is a routine method for the treatment of diabetes mellitus. One of the main challenges of a transplant with extraperitoneal placement of the pancreatic graft is impaired wound healing due to massive amylase and lipase secretion by the pancreatic graft, evoking edemtous fluid. From February 2002 through January 2003, we performed pancreatic transplant procedures in 21 patie...<br/><br/>L Janousek, M Adamec, F Saudek, R Koznarova, P Boucek, K Lipar, P Tosenovsky, I Matia (2004) <i>Transplant Proc</i> <i></i> <i></i> 36: 4 1099-1100<br/>

http://publicationslist.org/frantisek.saudek/refid28 2008-07-09T10:57:15Z

Although the number of pancreas transplants has increased significantly in previous years, debate continues concerning the optimum technique for exocrine pancreas drainage. Enteric drainage (ED) has recently been increasingly popular due to the long-term complications with bladder drainage (BD). We prospectively assigned 40 consecutive pancreas transplant recipients to either bladder (n = 20) or e...<br/><br/>M Adamec, L Janousek, K Lipár, F Hampl, F Saudek, R Koznarová, P Boucek, T Havrdová (2004) <i>Transplant Proc</i> <i></i> <i></i> 36: 4 1093-1094<br/>

http://publicationslist.org/frantisek.saudek/refid29 2008-07-09T10:57:15Z

BACKGROUND AND CASE: Simultaneous pancreas and kidney transplantation (SPK) is applied almost exclusively in C-peptide-negative type 1 diabetic patients, although some data on SPK in type 2 diabetes have been published as well. Nothing is known about SPK in the autosomal diabetes form, maturity-onset diabetes of the young (MODY). SPK was performed in a 47-year old man who has MODY3 because of a Ar...<br/><br/>Frantisek Saudek, Stepánka Průhová, Peter Boucek, Jan Lebl, Milos Adamec, Jakob Ek, Oluf Pedersen, Torben Hansen (2004) <i>Transplantation</i> <i></i> <i></i> 77: 8 1298-1301<br/>

http://publicationslist.org/frantisek.saudek/refid26 2008-07-09T10:57:15Z

In previous years, the number of pancreas transplants has increased significantly. Debate continues over the optimum technique for exocrine drainage. Enteric drainage (ED) has recently been increasingly popular owing to the long-term complications of bladder drainage (BD). We prospectively evaluated 40 consecutive pancreas transplant recipients undergoing either bladder (n = 20) or enteric (n = 20...<br/><br/>M Adamec, L Janouŝek, K Lipár, P Tosenovský, F Hampl, F Saudek, R Koznarová, P Boucek, T Havrdová (2004) <i>Transplant Proc</i> <i></i> <i></i> 36: 5 1524-1525<br/>

http://publicationslist.org/frantisek.saudek/refid30 2008-07-09T10:57:15Z

BACKGROUND: Simultaneous pancreas-kidney transplantation (SPK) transplantation has become an accepted therapy for type 1 diabetic patients with end-stage renal disease. This open-label, multicenter study compared the efficacy and safety of tacrolimus with the microemulsion (ME) formulation of cyclosporine in a clinical setting. The 1-year results are reported here. METHODS: The study was conducted...<br/><br/>Wolf Otto Bechstein, Jacques Malaise, Frantisek Saudek, Walter Land, Laureano Fernandez-Cruz, Raimund Margreiter, Richard Nakache, Antonio Secchi, Yves Vanrenterghem, Gunnar Tydén, Dominique Van Ophem, Thierry Berney, Peter Boucek, Rüdiger Landgraf, Andreas Kahl, Jean-Paul Squifflet (2004) <i>Transplantation</i> <i></i> <i></i> 77: 8 1221-1228<br/>

http://publicationslist.org/frantisek.saudek/refid25 2008-07-09T10:57:15Z

A promising treatment method for type 1 diabetes mellitus is transplantation of pancreatic islets containing beta-cells. The aim of this study was to develop an MR technique to monitor the distribution and fate of transplanted pancreatic islets in an animal model. Twenty-five hundred purified and magnetically labeled islets were transplanted through the portal vein into the liver of experimental r...<br/><br/>Daniel Jirák, Jan Kríz, Vít Herynek, Benita Andersson, Peter Girman, Martin Burian, Frantisek Saudek, Milan Hájek (2004) <i>Magn Reson Med</i> <i></i> <i></i> 52: 6 1228-1233<br/>

http://publicationslist.org/frantisek.saudek/refid12 2008-07-09T10:56:53Z

The destruction of pancreatic beta-cells in type 1 diabetes mellitus is mediated by autoreactive T-lymphocyte clones. We initiated a prospective randomized controlled trial of polyclonal rabbit anti-T-cell globulin (ATG) in patients with type 1 diabetes within 4 weeks of diagnosis and with residual post-glucagon C-peptide levels still over 0.3 nmol/l. ATG was administered as an initial bolus of 9 ...<br/><br/>Frantisek Saudek, Tereza Havrdova, Petr Boucek, Ludmila Karasova, Peter Novota, Jelena Skibova (2004) <i>Rev Diabet Stud</i> <i></i> <i></i> 1: 2 80-88<br/>

http://publicationslist.org/frantisek.saudek/refid23 2008-07-09T10:57:15Z

Transplantation of donor bone marrow cells (BMTx) has been proven to be capable of including allogeneic transplant tolerance. In our previous experiments we reported the positive effect of BMTx together with short-term tacrolimus/hydrocortisone therapy on pancreatic islet survival in recipients haploidentical with donors. In this project we used the same transplant protocol to further investigate ...<br/><br/>J Kriz, F Saudek, P Girman, P Novota (2004) <i>Int J Tissue React</i> <i></i> <i></i> 26: 3-4 75-83<br/>

http://publicationslist.org/frantisek.saudek/refid34 2008-07-09T10:58:10Z

Digital image analysis (DIA) is a new method in assessment of islet amount, which is expected to provide reliable and consistent results. We compared this method with conventional counting of small numbers of rat islets. Islets were isolated from 8 pancreases and counted in 24 samples in duplicate, first routinely by sizing according to estimated diameters under a calibrated reticule and then by p...<br/><br/>Peter Girman, Jan Kríz, Jozef Friedmanský, Frantisek Saudek (2003) <i>Cell Transplant</i> <i></i> <i></i> 12: 2 129-133<br/>

http://publicationslist.org/frantisek.saudek/refid33 2008-07-09T10:58:10Z

Only marginally improved results have been observed in standard autonomic function tests (AFT) in follow-up studies after simultaneous pancreas and kidney transplantation (SPK). We therefore used power spectral analysis (PSA) of heart rate variability (HRV) to assess the effect of SPK on autonomic neuropathy in patients with type I diabetes mellitus (DM I). We evaluated 82 patients with DM I who w...<br/><br/>P Boucek, F Saudek, M Adamec, L Janousek, R Koznarova, T Havrdova, J Skibova (2003) <i>Transplant Proc</i> <i></i> <i></i> 35: 4 1494-1498<br/>

http://publicationslist.org/frantisek.saudek/refid35 2008-07-09T10:58:10Z

AIMS/HYPOTHESIS: The aim of this study was to examine the prevalence and nature of mutations in HNF4alpha/MODY1, GCK/MODY2 and HNF-1alpha/MODY3 genes in Czech subjects with clinical diagnosis of MODY. METHODS: We studied 61 unrelated index probands of Czech origin (28 males, 33 females) with a clinical diagnosis of MODY and 202 family members. The mean age of probands was 22.7+/-12.0 years (range,...<br/><br/>S Pruhova, J Ek, J Lebl, Z Sumnik, F Saudek, M Andel, O Pedersen, T Hansen (2003) <i>Diabetologia</i> <i></i> <i></i> 46: 2 291-295<br/>

http://publicationslist.org/frantisek.saudek/refid32 2008-07-09T10:58:10Z

Transplantation of pancreas is presently the only way of treating diabetes of the 1st type, capable to secure a long-term normoglycemia. In spite of the fact that the surgical technique and tactics of the whole intervention has been standardized over the last years, surgical complications and more specifically vascular complications still pose a certain risk of the graft loss. The thrombosis of ve...<br/><br/>E Flaska, M Adamec, L Janousek, F Hampl, J Janek, F Saudek, R Koznarová, P Boucek, J Peregrin, J Kovac (2003) <i>Rozhl Chir</i> <i></i> <i></i> 82: 7 344-348<br/>

http://publicationslist.org/frantisek.saudek/refid31 2008-07-09T10:58:10Z

Multiple genetic factors are involved in the pathogenesis of type 1 and 2 diabetes mellitus. A defect, which could be ascribed to a single or only few genes, has not been established yet. An exception represents the Maturity Onset Diabetes of the Young (MODY) which is rather rare and is caused by mutations in some of 6 known genes. Principles of gene therapy focus mainly on generation of replenish...<br/><br/>F Saudek (2003) <i>Cas Lek Cesk</i> <i></i> <i></i> 142: 9 523-527<br/>

http://publicationslist.org/frantisek.saudek/refid37 2008-07-09T10:58:10Z

S Vítko, J Jirka, F Saudek, E Pokorná, K Filip (2002) <i>Cas Lek Cesk</i> <i></i> <i></i> 141: 14 460-461<br/>

http://publicationslist.org/frantisek.saudek/refid38 2008-07-09T10:58:10Z

BACKGROUND: Because they generally are older and frequently have co-morbidities, patients with type 2 diabetes mellitus and end-stage renal disease seldom are selected for renal transplantation. Thus, information on transplantation results from controlled studies in this high-risk category of patients is scarce. We have compared the results of kidney transplantations in type 2 diabetic patients wi...<br/><br/>Petr Boucek, Frantisek Saudek, Eva Pokorna, Stefan Vitko, Milos Adamec, Radomira Koznarova, Vera Lanska (2002) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 17: 9 1678-1683<br/>

http://publicationslist.org/frantisek.saudek/refid36 2008-07-09T10:58:10Z

Petr Boucek, Ludek Voska, Frantisek Saudek (2002) <i>Transplantation</i> <i></i> <i></i> 74: 10 <br/>

http://publicationslist.org/frantisek.saudek/refid42 2008-07-09T10:58:32Z

Hyperglycemia is an important factor in the development and progression of the complications of diabetes. Pancreas transplantation is currently the only method able to achieve sustained normoglycemia in type I diabetes. By now, this procedure has become an accepted treatment option combined with kidney transplantation for selected patients with end-stage diabetic nephropathy. The definite benefits...<br/><br/>F Saudek, P Boucek, M Adamec (2001) <i>Cas Lek Cesk</i> <i></i> <i></i> 140: 7 195-199<br/>

http://publicationslist.org/frantisek.saudek/refid43 2008-07-09T10:58:32Z

R Koznarová, F Saudek, T Hrachovinová, M Adamec, P Boucek, T Jedináková, Z Vlasáková, P Trunecka (2001) <i>Transplant Proc</i> <i></i> <i></i> 33: 1-2 <br/>

http://publicationslist.org/frantisek.saudek/refid41 2008-07-09T10:58:32Z

F Saudek, M Adamec, R Koznarová, T Jedináková, P Boucek, L Voska (2001) <i>Transplant Proc</i> <i></i> <i></i> 33: 3 2304-2306<br/>

http://publicationslist.org/frantisek.saudek/refid40 2008-07-09T10:58:10Z

The authors present the results of 100 pancreatico-duodenal grafts placed extraperitoneally with the bladder drainage. The onset of pancreatic graft function was immediate in all cases and the patients became insulin free. Despite the extraperitoneal graft placement the incidence of surgical complications was low. The only exception was slightly impaired wound healing. The Authors claim that this ...<br/><br/>M Adamec, L Janousek, F Saudek, P Tosenovský (2001) <i>Ann Transplant</i> <i></i> <i></i> 6: 2 41-42<br/>

http://publicationslist.org/frantisek.saudek/refid44 2008-07-09T10:58:32Z

Differences between the immunocytochemical behaviour of antisera to partially purified porcine gastrins and antisera to either synthetic human gastrin-17-I or highly purified porcine gastrin-17-I raised the hypothesis that hog antral gastrin extracts contain peptides different from somatostatin and gastrin that are responsible for the immunocytochemical reaction of the former antisera in the D (de...<br/><br/>R Lomský, J Príbysová, V Jirkalová, F Saudek (2001) <i>J Endocrinol</i> <i></i> <i></i> 168: 3 391-400<br/>

http://publicationslist.org/frantisek.saudek/refid39 2008-07-09T10:58:10Z

OBJECTIVE: Specific immune tolerance achieved by induction of lymphocyte chimerism could reduce the need for immunosuppressive therapy in pancreatic islet transplantation. The aim of the experiment was to assess the effect of pre-treatment with donor specific bone marrow on the function of allogeneic islets under the conditions of a short-term immunosuppression. METHODS: Male Lewis-Brown Norway an...<br/><br/>P Girman, J Kríz, E Dovolilová, E Cíhalová, F Saudek (2001) <i>Ann Transplant</i> <i></i> <i></i> 6: 2 43-45<br/>

http://publicationslist.org/frantisek.saudek/refid45 2008-07-09T10:58:32Z

In pancreas recipients with advanced diabetic eye disease, conflicting ophthalmologic results over different follow-up periods have been reported. In the present prospective study we performed ophthalmologic evaluation groups of type I diabetic patients: 1) normoglycemic recipients of pancreas and kidney grafts (group SPK, n = 43, follow-up 44.9 +/- 35.1 months), 2) pancreas and kidney graft recip...<br/><br/>R Koznarová, F Saudek, T Sosna, M Adamec, T Jedináková, P Boucek, V Bartos, V Lánská (2000) <i>Cell Transplant</i> <i></i> <i></i> 9: 6 903-908<br/>

http://publicationslist.org/frantisek.saudek/refid47 2008-07-09T10:58:32Z

Cryopreservation is the only available technique for long-term storage of pancreatic islets. The freezing/thawing protocol may cause considerable loss of viable islet tissue and impair its function in vivo. The aim of this study was to investigate glucose and insulin levels after transplantation of fresh and cryo/thawed rat islets. Rat pancreatic islets were isolated following intraductal collagen...<br/><br/>F Saudek, E Cíhalová, L Karasová, P Kobylka, R Lomský (1999) <i>J Mol Med</i> <i></i> <i></i> 77: 1 107-110<br/>

http://publicationslist.org/frantisek.saudek/refid50 2008-07-09T10:58:32Z

F Saudek, T Jedináková, M Adamec (1998) <i>Transplant Proc</i> <i></i> <i></i> 30: 2 <br/>

http://publicationslist.org/frantisek.saudek/refid49 2008-07-09T10:58:32Z

M Adamec, F Saudek, P Tosenovský, L Janousek (1998) <i>Transplant Proc</i> <i></i> <i></i> 30: 2 <br/>

http://publicationslist.org/frantisek.saudek/refid48 2008-07-09T10:58:32Z

The treatment of diabetic retinopathy (DR) is one of the most challenging problems in ophthalmology. The possibility of modulating DR by successful combined kidney and pancreas transplantation thus holds an attractive promise for the ophthalmologist. From June 1983 until April 1997, a total of 86 combined kidney and pancreas transplantation procedures were performed at the Prague-based Institute f...<br/><br/>T Sosna, F Saudek, Z Domínek (1998) <i>Acta Univ Palacki Olomuc Fac Med</i> <i></i> <i></i> 141: 75-77<br/>

http://publicationslist.org/frantisek.saudek/refid46 2008-07-09T10:58:32Z

The most frequently used surgical technique in transplantations of the pancreas is to connect the duodenum of the graft with the urinary bladder of the recipient. Introduction of this method led during the last five years to marked improvement of results. On the other hand duodenocystoanastomosis is a frequent cause of metabolic and urological complications in patients after transplantation. The a...<br/><br/>M Adamec, F Bĕlina, F Saudek, P Tosenovský, L Janousek, M Ryska (1998) <i>Rozhl Chir</i> <i></i> <i></i> 77: 12 548-550<br/>

http://publicationslist.org/frantisek.saudek/refid56 2008-07-09T10:58:44Z

The number of combined transplantations of the pancreas and kidney in type I diabetics with chronic renal failure is increasing every year. The authors present their experience with a new technique of duodenocystostomy during this transplantation. The use of a circular stapler to create the duodenocystoanastomosis can hasten the surgical procedure and reduce at the same time the risk of developmen...<br/><br/>M Adamec, F Saudek, P Tosenovský, L Janousek (1997) <i>Rozhl Chir</i> <i></i> <i></i> 76: 7 336-338<br/>

http://publicationslist.org/frantisek.saudek/refid57 2008-07-09T10:58:44Z

F Saudek, E Cíhalová, L Karasová (1997) <i>Transplant Proc</i> <i></i> <i></i> 29: 4 1963-1964<br/>

http://publicationslist.org/frantisek.saudek/refid55 2008-07-09T10:58:44Z

BACKGROUND. By transplantation of the pancreas in diabetics type 1 long-term-term independence on exogenous insulin can be achieved. The extent of normalization of the carbohydrate metabolism can depend on the applied surgical technique. The objective of the submitted work was to compare indicators of compensation of diabetes one year after combined transplantation of the kidney and pancreas, usin...<br/><br/>F Saudek, M Adamec, V Bartos, R Koznarová, P Boucek, Z Vlasáková, L Karasová, R Petrásek (1997) <i>Cas Lek Cesk</i> <i></i> <i></i> 136: 14 434-438<br/>

http://publicationslist.org/frantisek.saudek/refid54 2008-07-09T10:58:44Z

M Adamec, F Saudek (1997) <i>Transplant Proc</i> <i></i> <i></i> 29: 7 <br/>

http://publicationslist.org/frantisek.saudek/refid51 2008-07-09T10:58:44Z

F Saudek, T Jedináková, M Adamec, Z Vlasáková, V Bartos (1997) <i>Transplant Proc</i> <i></i> <i></i> 29: 7 <br/>

http://publicationslist.org/frantisek.saudek/refid52 2008-07-09T10:58:44Z

F Saudek, M Adamec, V Bartos, Z Vlasáková, P Boucek, J Koznarová, A Jirkovská, S Vítko (1997) <i>Transplant Proc</i> <i></i> <i></i> 29: 7 <br/>

http://publicationslist.org/frantisek.saudek/refid53 2008-07-09T10:58:44Z

M Adamec, F Saudek (1997) <i>Transplant Proc</i> <i></i> <i></i> 29: 7 <br/>

http://publicationslist.org/frantisek.saudek/refid61 2008-07-09T10:59:00Z

The authors present the case-record of a patient after combined transplantation of the pancreas and kidney who developed a chronic duodenocutaneous fistula. The case was resolved by elimination of the duodenocystoanastomosis of the transplanted pancreas and by obliteration of the pancreatic duct of the graft by a polymer. One year after surgery the patient has no complaints and the function of bot...<br/><br/>M Adamec, F Saudek, P Brůcek (1996) <i>Rozhl Chir</i> <i></i> <i></i> 75: 4 191-193<br/>

http://publicationslist.org/frantisek.saudek/refid60 2008-07-09T10:58:44Z

BACKGROUND: Successful transplantation of the pancreas is at present the only way how to ensure on a long-term basis an almost physiological regulation of the carbohydrate metabolism in type 1 diabetics. So far it is, however, indicated mainly in patients with already advanced microangiopathy where at the same time also renal transplantation is planned and long-term experience is so far limited. T...<br/><br/>F Saudek, V Bartos, I Vanĕk, M Adamec, R Koznarová, T Sosna, P Boucek, H Vondrová (1996) <i>Cas Lek Cesk</i> <i></i> <i></i> 135: 11 348-353<br/>

http://publicationslist.org/frantisek.saudek/refid58 2008-07-09T10:58:44Z

M Adamec, H Ekberg, I Vanĕk, P Pavel, F Saudek, V Bartos (1996) <i>Transplant Proc</i> <i></i> <i></i> 28: 6 <br/>

http://publicationslist.org/frantisek.saudek/refid59 2008-07-09T10:58:44Z

BACKGROUND: Transplantation of isolated islets of Langerhans is a perspective method of treating type 1 diabetes. The first prerequisite for its implementation is to obtain sufficient amounts of vital islets. The objective to the authors' experiments was to introduce a method of massive isolation of islets of Langerhans from dogs which would serve as a model pro obtaining islets of Langerhans from...<br/><br/>F Saudek, E Cíhalová, I Zufanová, M Adamec (1996) <i>Cas Lek Cesk</i> <i></i> <i></i> 135: 18 594-596<br/>

http://publicationslist.org/frantisek.saudek/refid62 2008-07-09T10:59:00Z

F Saudek, M Adamec, H Ekberg, R Koznarová, P Boucek, V Bartos (1995) <i>Transplant Proc</i> <i></i> <i></i> 27: 6 3080-3081<br/>

http://publicationslist.org/frantisek.saudek/refid63 2008-07-09T10:59:00Z

Glucose tolerance, insulin secretion and in vitro insulin action were examined in streptozotocin-induced diabetic rats following pancreatic islet allotransplantation treated with combination of oral cyclosporine A (10 mg/kg) and hydrocortisone (1.5 mg/kg) intramuscularly. 1400 pure islets from multiple donors were implanted either into the portal vein (n = 10) or under the renal capsule (n = 11). ...<br/><br/>F Saudek, L Kazdová, M Nozicková, A Vrána, E Cíhalová, V Ruzbarský (1995) <i>Physiol Res</i> <i></i> <i></i> 44: 2 79-86<br/>

http://publicationslist.org/frantisek.saudek/refid65 2008-07-09T10:59:00Z

BACKGROUND. Glucose tolerance depends essentially on insulin secretion and its action in target tissues. Diabetes mellitus type II (insulin-nondependent diabetes) is a disease conditioned by a dysbalance between insulin secretion and effect; it has not been decided whether the cause is insulin resistance or impaired insulin secretion, although a defect of insulin secretion for the manifestation of...<br/><br/>T Pelikánová, J Válek, L Kazdová, F Saudek, L Karasová (1994) <i>Cas Lek Cesk</i> <i></i> <i></i> 133: 6 172-176<br/>

http://publicationslist.org/frantisek.saudek/refid66 2008-07-09T10:59:00Z

BACKGROUND. One of the substances used in recent years to suppress immune reactions after organ and tissue transplantations is mouse IgG2a globulin which acts selectively on CD3 lymphocytes; it is known under the name of Orthoclone (Ortho Co.) An analogous preparation was developed in the Institute of Molecular Genetics, Academy of Sciences, Czech Republic, although the idiotype is different. The ...<br/><br/>J Jirka, P Rossmann, J Tĕsínská, I Reneltová, F Saudek, J Kaslíková, J Gintelová, I Matl, J Kaslík (1994) <i>Cas Lek Cesk</i> <i></i> <i></i> 133: 3 76-79<br/>

http://publicationslist.org/frantisek.saudek/refid64 2008-07-09T10:59:00Z

M F Ansara, F Saudek, M Newton, A C Raynor, P E Cryer, D W Scharp (1994) <i>Transplant Proc</i> <i></i> <i></i> 26: 2 664-665<br/>

http://publicationslist.org/frantisek.saudek/refid68 2008-07-09T10:59:00Z

In the decade 1979-1988, 658 biopsies were collected from 568 cadaveric renal allografts. In 118 grafts a non-proliferative insudative vasculopathy (IVA) was found in afferent vessels. Immunosuppression was based on azathioprine (AZA) or on cyclosporin A (CsA), from 1983. The prevalence and extent of IVA has increased significantly since 1984. Light microscopy showed fibrinoid and hyaline masses o...<br/><br/>P Rossmann, J Jirka, M Chadimová, I Reneltová, F Saudek (1991) <i>Virchows Arch A Pathol Anat Histopathol</i> <i></i> <i></i> 418: 2 129-141<br/>

http://publicationslist.org/frantisek.saudek/refid67 2008-07-09T10:59:00Z

Insulin action and insulin specific binding to erythrocytes were examined in ten recipients of a pancreatic segment and renal graft (Group 1), in nine non-diabetic kidney recipients (Group 2) and in ten age- and weight-matched healthy control subjects (Group 3). All transplant recipients were normoglycaemic without need of insulin, received the same immunosuppression and had good renal graft funct...<br/><br/>F Saudek, T Pelikánová, V Bartos, I Reneltová, L Kazdová, J Kovár, L Karasová (1991) <i>Diabetologia</i> <i></i> <i></i> 34 Suppl 1: S71-S75<br/>

http://publicationslist.org/frantisek.saudek/refid71 2008-07-09T11:00:40Z

Diabetic nephropathy affects half the type 1 diabetics and is the most frequent cause of death there. While in some countries diabetics account for 25-30% of all patients newly admitted in dialysis and transplantation programmes, in Czechoslovakia the number of diabetics treated by dialysis or transplantation is small. From August 1985 to June 1988, 15 isolated kidney transplant operations were pe...<br/><br/>J Malý, F Saudek, V Bartos, I Vanĕk, P Boucek, J Bláha, V Kocandrle (1990) <i>Czech Med</i> <i></i> <i></i> 13: 2-3 90-97<br/>

http://publicationslist.org/frantisek.saudek/refid70 2008-07-09T10:59:00Z

The authors compared the survival of four groups of patients and of renal grafts: 1. diabetics after renal transplantation (24 subjects), 2. diabetics after transplantation of the kidney and pancreas (35 subjects), 3. diabetics where transplantation was indicated but who were treated only by dialysis and 4. non-diabetics after transplantation of the kidney (170 subjects). The two-year cumulative s...<br/><br/>F Saudek, V Bartos, V Martínek, V Lánská, J Malý (1990) <i>Cas Lek Cesk</i> <i></i> <i></i> 129: 40 1256-1260<br/>

http://publicationslist.org/frantisek.saudek/refid69 2008-07-09T10:59:00Z

Sixteen type I diabetics were followed up from the neurological aspect and by electromyography for 6 to 42 months following successful combined transplantation of the pancreas and kidney. Before transplantation all patients suffered from medium severe to severe peripheral polyneuropathy, grade 3-5 according to the commonly used quantitative classification. All patients reported after transplantati...<br/><br/>H Vondrová, V Bartos, F Saudek, I Vanĕk (1990) <i>Cas Lek Cesk</i> <i></i> <i></i> 129: 45 1416-1420<br/>

http://publicationslist.org/frantisek.saudek/refid75 2008-07-09T11:00:40Z

Continuous subcutaneous insulin infusion (CSII) was combined with antirejection therapy in four diabetic recipients of pancreas and kidney grafts with persisting hyperglycemia due to pancreas rejection. In three of the patients, full function of the pancreas was restored after as many as 40, 86, and 139 days of CSII. In another patient, the dose of insulin was halved, and his graft function was cl...<br/><br/>V Bartos, I Vanĕk, M Dryáková, F Saudek, J Malý (1989) <i>Diabetes</i> <i></i> <i></i> 38 Suppl 1: 71-73<br/>

http://publicationslist.org/frantisek.saudek/refid74 2008-07-09T11:00:40Z

Pharmacokinetics of cefoperazone was studied in 10 healthy volunteers and in 11 patients with liver cirrhosis. In the same persons, we also examined the clearance of ujoviridin--a preparation of indocyanine green. Within 12 h, 31.8 (+/- 7.6)% of the 2 g dose of cefoperazone was eliminated in the urine of healthy persons and 74.3 (+/- 7.9)% (mean +/- SD) was eliminated in the urine of cirrhotics. T...<br/><br/>F Saudek, J Morávek, Z Modr (1989) <i>Int J Clin Pharmacol Ther Toxicol</i> <i></i> <i></i> 27: 2 82-87<br/>

http://publicationslist.org/frantisek.saudek/refid73 2008-07-09T11:00:40Z

Results of pars plana vitrectomy (PPV) were compared in two groups of patients. The first group was formed from 105 eyes of 87 diabetics without clinical signs of the diabetic nephropathy or nephropathy without decrease of renal functions. The other group was formed from 64 eyes of 50 diabetics suffering from diabetic nephropathy in the stage of the renal insufficiency. In the first group PPV was ...<br/><br/>I Karel, B Kalvodová, J Kondrová, P Bedrich, P Markvart, F Saudek, M Dosková (1989) <i>Cesk Oftalmol</i> <i></i> <i></i> 45: 2 77-83<br/>

http://publicationslist.org/frantisek.saudek/refid72 2008-07-09T11:00:40Z

Diabetic nephropathy affects half the type I diabetics and is their most frequent cause of death. While in some countries diabetics account for 25-30% of all newly admitted patients in dialyzation-transplantation programmes, in the CSSR the number of diabetic patients treated by dialyzation or transplantation is small. From August 1985 to June 1988 in the Institute of Clinical and Experimental Med...<br/><br/>J Malý, F Saudek, V Bartos, I Vanĕk, P Boucek, J Bláha, V Kocandrle (1989) <i>Cas Lek Cesk</i> <i></i> <i></i> 128: 10 311-314<br/>

http://publicationslist.org/frantisek.saudek/refid79 2008-07-09T11:00:40Z

Having reviewed the state-of-the art trends in pancreas transplantation over the world, the authors describe their own experimental studies preceding elaboration of the technique of pancreatic segment transplantation with duct obliteration. In their technique, the splenic artery is interposed in the course of the iliac arteries of the recipient. The procedure of the selection of diabetic patients ...<br/><br/>V Bartos, I Vanĕk, F Saudek, P Pavel, K Vondra, V Kocandrle (1987) <i>Czech Med</i> <i></i> <i></i> 10: 1 39-46<br/>

http://publicationslist.org/frantisek.saudek/refid78 2008-07-09T11:00:40Z

F Saudek, V Bartos, I Vanĕk, P Pavel, L Karasová, K Vondra, V Kocandrle (1987) <i>Cas Lek Cesk</i> <i></i> <i></i> 126: 12 364-368<br/>

http://publicationslist.org/frantisek.saudek/refid76 2008-07-09T11:00:40Z

F Saudek, Z Modr (1987) <i>Cas Lek Cesk</i> <i></i> <i></i> 126: 45 1413-1418<br/>

http://publicationslist.org/frantisek.saudek/refid77 2008-07-09T11:00:40Z

I Karel, B Kalvodová, F Saudek (1987) <i>Cas Lek Cesk</i> <i></i> <i></i> 126: 30 940-943<br/>

http://publicationslist.org/frantisek.saudek/refid80 2008-07-09T11:00:40Z

Pharmacokinetics of cefoperazone was studied in 10 healthy volunteers following 15 min intravenous infusion of 2 g. Cefoperazone levels in the blood serum and in the urine were determined microbiologically. At the end of the infusion, mean serum concentrations of the antibiotic were 340.4 (+/- 81.5) mg/l, at the 4th hour after the infusion 38.4 (+/- 10.3) mg/l, and 12 hours after the infusion all ...<br/><br/>F Saudek, J Morávek, Z Modr (1986) <i>Czech Med</i> <i></i> <i></i> 9: 3 162-165<br/>

http://publicationslist.org/frantisek.saudek/refid82 2008-07-09T11:04:03Z

F Saudek, Z Modr (1985) <i>Cas Lek Cesk</i> <i></i> <i></i> 124: 27 851-855<br/>

http://publicationslist.org/frantisek.saudek/refid83 2008-07-09T11:04:03Z

V Bartos, K Vondra, I Vanĕk, K Neuwirtová, F Saudek, V Kocandrle (1985) <i>Cas Lek Cesk</i> <i></i> <i></i> 124: 7 193-197<br/>

http://publicationslist.org/frantisek.saudek/refid81 2008-07-09T11:04:03Z

V Bartos, I Vanĕk, P Pavel, K Neuwirtová, F Saudek, L Karasová, K Vondra, V Kocandrle (1985) <i>Cas Lek Cesk</i> <i></i> <i></i> 124: 45 1395-1399<br/>

http://publicationslist.org/frantisek.saudek/refid86 2008-07-09T11:04:03Z

F Saudek (1984) <i>Cas Lek Cesk</i> <i></i> <i></i> 123: 7 181-185<br/>

http://publicationslist.org/frantisek.saudek/refid87 2008-07-09T11:04:03Z

F Saudek (1984) <i>Cas Lek Cesk</i> <i></i> <i></i> 123: 1 15-20<br/>

http://publicationslist.org/frantisek.saudek/refid85 2008-07-09T11:04:03Z

F Saudek (1984) <i>Cas Lek Cesk</i> <i></i> <i></i> 123: 14 416-420<br/>

http://publicationslist.org/frantisek.saudek/refid84 2008-07-09T11:04:03Z

F Saudek (1984) <i>Cas Lek Cesk</i> <i></i> <i></i> 123: 33 1018-1023<br/>

http://publicationslist.org/frantisek.saudek/refid88 2008-07-09T11:04:03Z

K Filip, F Saudek (1983) <i>Cas Lek Cesk</i> <i></i> <i></i> 122: 27 845-849<br/>

http://publicationslist.org/frantisek.saudek/refid89 2008-07-09T11:04:03Z

F Saudek (1983) <i>Cas Lek Cesk</i> <i></i> <i></i> 122: 15 452-458<br/>