http://publicationslist.org/data/george.loizou/atom.xml George LOIZOUhttp://publicationslist.org/george.loizou$basepathfavicon.icoRecent additions to George LOIZOU's PublicationsList.org pagehttp://publicationslist.org/publications.png2010-11-01T10:37:25Z http://publicationslist.org/george.loizou/refid41 2010-11-01T10:36:42Z

There have been several studies on the maternal administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and effects in the reproductive tract of male offspring, subsequent to risk assessments undertaken in 2001. This review compares the methodology and results to examine key methodological features, and consistency in reported outcomes. Maternal dosing at >0.8mug TCDD/kg causes lethality and ...<br/><br/>D R Bell, S Clode, M Q Fan, A Fernandes, P M Foster, T Jiang, G Loizou, A Macnicoll, B G Miller, M Rose, L Tran, S White (2010) <i>Food Chem Toxicol</i> <i></i> <i>file:///N:/Endnote%20library/References/Bell%20et%20al%20(2010)%20Food%20Chem%20Toxicol%20(48)%20(1439-1447)%20.pdf</i> 48: 1439-1447<br/>

http://publicationslist.org/george.loizou/refid36 2010-11-01T10:36:42Z

The Aryl Hydrocarbon Receptor (AhR) is required for the toxicity of TCDD, and so the AhR of CRL:WI and CRL:WI(Han) rats was characterised. Western blot showed AhR proteins of approximately 110 and approximately 97 kDa in individual rats from both strains. The AhR cDNA from a CRL:WI(Han) rat with the approximately 110kDa protein revealed a sequence that was identical to that of the CRL:WI and SD ra...<br/><br/>T Jiang, D R Bell, S Clode, M Q Fan, A Fernandes, P M Foster, G Loizou, A Macnicoll, B G Miller, M Rose, L Tran, S White (2009) <i>Toxicol Sci</i> <i></i> <i>file:///N:/Endnote%20library/References/Jiang%20et%20al%20(2009)%20Tox%20Sci%20107(2)%20(512-521).pdf</i> 107: 2 512-521<br/>

http://publicationslist.org/george.loizou/refid37 2010-11-01T10:36:42Z

Ming Qi Fan, Alex R Bell, David R Bell, Sally Clode, Alwyn Fernandes, Paul M D Foster, Jeffrey R Fry, Tao Jiang, George Loizou, Alan MacNicoll, Brian G Miller, Martin Rose, Osama Shaikh-Omar, Chi Lang Tran, Shaun White (2009) <i>Analytical Biochemistry</i> <i></i> <i>file://N:%5CEndnote%20library%5CReferences%5CFan%20et%20al%20(2009)%20Anal%20Biochem%20348%20(279-287).pdf</i> Ahead of print: <br/>

http://publicationslist.org/george.loizou/refid39 2010-11-01T10:36:42Z

Kannan Krishnan, George Loizou, John C Lipscomb, Martin Spendiff, Melvin E Andersen (2009) <i></i> <i></i> <i></i> : <br/>

http://publicationslist.org/george.loizou/refid40 2010-11-01T10:36:42Z

H A Barton, J Bessems, M Bouvier d'Yvoire, H Buist, H Clewell III, U Gundert-Remy, K Krishnan, J Lipscomb, G Loizou, B Meek, D Moir, M Spendiff (2009) <i></i> <i></i> <i>http://www.who.int/ipcs/methods/harmonization/areas/pbpk_guidance/en/index.html</i> : <br/>

http://publicationslist.org/george.loizou/refid38 2010-11-01T10:36:42Z

G Loizou (2009) <i></i> <i></i> <i></i> : 29-32<br/>

http://publicationslist.org/george.loizou/refid34 2010-11-01T10:36:42Z

G D Loizou, M Spendiff, H A Barton, J Bessems, F Y Bois, d'Yvoire Bouvier, H Buist, H Clewell III, U Gundert-Remy, G Goerlitz, B Meek, W Schmitt (2008) <i>Regulatory Toxicology and Pharmacology</i> <i></i> <i>file://N:%5CEndnote%20library%5CReferences%5CLoizou%20et%20al%20(2008)%20Reg%20Tox%20Pharm%2050%20(400-411)%20.pdf</i> 50: 400-411<br/>

http://publicationslist.org/george.loizou/refid29 2010-11-01T10:36:42Z

We compared the effects of a single acute dose, or chronic fetal exposure, to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the male reproductive system of the Wistar(Han) rat. Tissue samples were taken from dams on GD16 and GD21, and from offspring on PND70 and 120. Steady state concentration of TCDD was demonstrated in the chronic study: body burdens were comparable in both studies. Fetal TCDD c...<br/><br/>D R Bell, S Clode, M Q Fan, A Fernandes, P M Foster, T Jiang, G Loizou, A Macnicoll, B G Miller, M Rose, L Tran, S White (2007) <i>Toxicological Sciences</i> <i></i> <i>file://N:%5CEndnote%20library%5CReferences%5CBell%20et%20al%20(2007)%20Tox%20Sci%2099(2)%20(591-604).pdf</i> 99: 591-604<br/>

http://publicationslist.org/george.loizou/refid35 2010-11-01T10:36:42Z

Michel Bouvier d'Yvoire, Pilar Prieto, Bas J Blaauboer, Frederic Y Bois, Alan Boobis, Céline Brochot, Sandra Coecke, Andreas Freidig, Ursula Gundert-Remy, Thomas Hartung, Miriam N Jacobs, Thierry Lavé, David E Leahy, Hans Lennernäs, George D Loizou, Bette Meek, Camilla Pease, Malcolm Rowland, Martin Spendiff, Jiansong Yang, Marco Zeilmaker (2007) <i>ATLA-Alternatives To Laboratory Animals</i> <i></i> <i>file://N:%5CEndnote%20library%5CReferences%5CBouvier%20d'Yvoire%20(2007)%20ATLA%2035%20(661-671).pdf</i> 35: 661-671<br/>

http://publicationslist.org/george.loizou/refid31 2010-11-01T10:36:42Z

We have investigated whether fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes defects in the male reproductive system of the rat, using chronically exposed rats to ensure continuous exposure of the fetus. 5-6 week old rats were exposed to control diet, or diet containing TCDD, to attain an average dose of 2.4, 8 and 46 ng TCDD kg(-1) day(-1) for twelve weeks, whereupon the rats ...<br/><br/>D R Bell, S Clode, M Q Fan, A Fernandes, P M Foster, T Jiang, G Loizou, A Macnicoll, B G Miller, M Rose, L Tran, S White (2007) <i>Toxicological Sciences</i> <i></i> <i>file://N:%5CEndnote%20library%5CReferences%5CBell%20et%20al%20(2007)%20Tox%20Sci%2099(1)%20224-233).pdf</i> 99: 224-233<br/>

http://publicationslist.org/george.loizou/refid30 2010-11-01T10:36:42Z

It has been reported that fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes defects in the male reproductive system of the rat. We set out to replicate and extend these effects using a robust experimental design. Groups of 75 (control vehicle) or 55 (50, 200 or 1000 ng of TCDD kg(-1) bodyweight) female Wistar(Han) rats were exposed to TCDD on Gestational Day (GD) 15, then allowed...<br/><br/>D R Bell, S Clode, M Q Fan, A Fernandes, P M Foster, T Jiang, G Loizou, A Macnicoll, B G Miller, M Rose, L Tran, S White (2007) <i>Toxicological Sciences</i> <i></i> <i>file://N:%5CEndnote%20library%5CReferences%5CBell%20et%20al%20(2007)%20Tox%20Sci%2099(1)%20(214-223).pdf</i> 99: 214-223<br/>

http://publicationslist.org/george.loizou/refid32 2010-11-01T10:36:42Z

Physiologically-based pharmacokinetic (PBPK) models are used in mode-of-action based risk and safety assessments to estimate internal dosimetry in animals and humans. When used in risk assessment, these models can provide a basis for extrapolating between species, doses and exposure routes or for justifying non-default values for uncertainty factors. Characterization of uncertainty and variability...<br/><br/>H A Barton, W A Chiu, R W Setzer, M E Andersen, A J Bailer, F Y Bois, R S Dewoskin, S Hays, G Johanson, N Jones, G Loizou, R C Macphail, C J Portier, M Spendiff, Y M Tan (2007) <i>Toxicological Sciences</i> <i></i> <i>file://N:%5CEndnote%20library%5CReferences%5CBarton%20et%20al%20(2007)%20Tox%20Sci%2099%20(395-402).pdf</i> 99: 395-402<br/>

http://publicationslist.org/george.loizou/refid27 2010-11-01T10:36:42Z

A physiologically based pharmacokinetic (PBPK) model describing the disposition of 2-butoxyethanol (2-BE) was developed in order to predict the urinary concentration of its major metabolite, butoxyacetic acid (BAA) under a range of exposure scenarios. Based on Corley et al. [Corley, R.A., Bormett, G.A., Ghanayem, B.I., 1994. Physiologically based pharmacokinetics of 2-butoxyethanol and its major m...<br/><br/>S J Franks, M K Spendiff, J Cocker, G D Loizou (2006) <i>Toxicology Letters</i> <i></i> <i>file://N:%5CEndnote%20library%5CReferences%5CFranks%20et%20al%20(2006)%20Tox%20Lett%20162%20(164-173).pdf</i> 162: 2-3 164-73<br/>

http://publicationslist.org/george.loizou/refid33 2010-11-01T10:36:42Z

R Combes, M Balls, P Illing, N Bhogal, J Dale, G Duve, V Feron, C Grindon, M Gulden, G Loizou, R Priston, C Westmoreland (2006) <i>Altern Lab Anim</i> <i></i> <i>file://N:%5CEndnote%20library%5CReferences%5CCombes%20et%20al%20(2006)%20ATLA%2034%20(621-649).pdf</i> 34: 6 621-49<br/>

http://publicationslist.org/george.loizou/refid23 2010-11-01T10:36:42Z

George Loizou, Craig Sams (2004) <i></i> <i></i> <i></i> : <br/>

http://publicationslist.org/george.loizou/refid24 2010-11-01T10:36:42Z

R Combes, M Balls, L Bansil, M Barratt, D Bell, P Botham, C Broadhead, R Clothier, E George, J Fentem, M Jackson, I Indans, G Loizou, V Navaratnam, V Pentreath, B Phillips, H Stemplewski, J Stewart (2004) <i>Atla-Alternatives to Laboratory Animals</i> <i></i> <i></i> 32 Supplement 1: 635-642<br/>

http://publicationslist.org/george.loizou/refid28 2010-11-01T10:36:42Z

G D Loizou (2004) <i></i> <i></i> <i>http://www.publicservice.co.uk/pdf/dti/6/DTI6%200601%20Georg%E2%80%A6Loizou%20ATL.pdf</i> : 57-59<br/>

http://publicationslist.org/george.loizou/refid25 2010-11-01T10:36:42Z

The enzyme kinetics of the initial hydroxylation of ethylbenzene to form 1-phenylethanol were determined in human liver microsomes. The individual cytochrome P450 (CYP) forms catalysing this reaction were identified using selective inhibitors and recombinant preparations of hepatic CYPs. Production of 1-phenylethanol in hepatic microsomes exhibited biphasic kinetics with a high affinity, low Km, c...<br/><br/>C Sams, G D Loizou, J Cocker, M S Lennard (2004) <i>Toxicol Lett</i> <i></i> <i></i> 147: 3 253-60<br/>

http://publicationslist.org/george.loizou/refid26 2010-11-01T10:36:42Z

A physiologically based pharmacokinetic model for investigating inter-individual and inter-racial variability in ethanol pharmacokinetics is presented. The model is a substantial modification of an existing model which described some genetic polymorphisms in the hepatic alcohol dehydrogenase enzymes. The model was modified to incorporate a description of ethanol absorption from the stomach and gas...<br/><br/>G D Loizou, M Spendiff (2004) <i>Journal of Molecular Histology</i> <i></i> <i>file://N:%5CEndnote%20library%5CReferences%5CLoizou%20and%20Spendiff%20(2004)%20J%20Molecular%20Histology%2035%20(687-696).pdf</i> 35: 7 687-96<br/>

http://publicationslist.org/george.loizou/refid17 2010-11-01T10:36:42Z

The construction of a homology model of human cytochrome P450 2E1 (CYP2E1) is reported, based on the CYP2C5 crystallographic template. A relatively high degree of primary sequence homology (identity=59%), as expected for proteins of the same CYP family, ensured a straightforward generation of the 3-dimensional model due to relatively few deletions and insertions of amino acid residues with respect...<br/><br/>D F Lewis, B G Lake, M G Bird, G D Loizou, M Dickins, P S Goldfarb (2003) <i>Toxicology In Vitro</i> <i></i> <i></i> 17: 1 93-105.<br/>

http://publicationslist.org/george.loizou/refid16 2010-11-01T10:36:42Z

David. F V Lewis, Craig. Sams, George D Loizou (2003) <i> Journal of Biochemical and Molecular Toxicology</i> <i></i> <i></i> 17: 1 47-52<br/>

http://publicationslist.org/george.loizou/refid18 2010-11-01T10:36:42Z

G Loizou (2003) <i>Toxicology Letters</i> <i></i> <i>file://N:%5CEndnote%20library%5CReferences%5CLoizou%20(2003)%20Tox%20Lett%20138%20(179-182).pdf</i> 138: 1-2 181-2.<br/>

http://publicationslist.org/george.loizou/refid20 2010-11-01T10:36:42Z

G Loizou, M Spendiff, M Penney, E Pryde (2003) <i>Toxicology Letters</i> <i></i> <i></i> 114 (Suppl. 1): <br/>

http://publicationslist.org/george.loizou/refid19 2010-11-01T10:36:42Z

George D Loizou, Martin K Spendiff (2003) <i></i> <i>Exposure assessment in occupational and environmental epidemiology</i> <i></i> : 151-165<br/>

http://publicationslist.org/george.loizou/refid15 2010-11-01T10:36:42Z

R Combes, M Balls, L Bansil, M Barratt, D Bell, P Botham, C Broadhead, R Clothier, E George, J Fentem, M Jackson, I Indans, G Loizou, V Navaratnam, V Pentreath, B Phillips, H Stemplewski, J Stewart (2002) <i>Altern Lab Anim</i> <i></i> <i></i> 30: 4 365-406.<br/>

http://publicationslist.org/george.loizou/refid14 2010-11-01T10:36:42Z

The effects of acute administration of dietary levels of ethanol and the garlic oil extract, diallyl sulphide (DAS), on cytochrome P450 2E1 (CYP2E1) activity in volunteers were studied using the selective probe substrate, chlorzoxazone (CZX). The ratio of the CZX metabolite 6- hydroxychlorzoxazone (6-OHCZX) to CZX was taken to indicate CYP2E1 activity. The mean differences between the baseline and...<br/><br/>G D Loizou, J Cocker (2001) <i>Human and Experimental Toxicology</i> <i></i> <i>file://N:%5CEndnote%20library%5CReferences%5CLoizou%20and%20Cocker%20(2001)%20Human%20Exp%20Toxicol%2020%20(321-327).pdf</i> 20: 7 321-7.<br/>

http://publicationslist.org/george.loizou/refid13 2010-11-01T10:36:42Z

G D Loizou (2001) <i>Toxicology Letters</i> <i></i> <i></i> 124: 1-3 59-69<br/>

http://publicationslist.org/george.loizou/refid21 2010-11-01T10:36:42Z

Occupational exposure limits (OELs) for individual substances are established on the basis of the available toxicological information at the time of their promulgation, expert interpretation of these data in light of industrial use, and the framework in which they sit. In the United Kingdom, the establishment of specific OELs includes the application of uncertainty factors to a defined starting po...<br/><br/>J I Delic, P D Lilly, A J MacDonald, G D Loizou (2000) <i>Regulatory Toxicology and Pharmacology</i> <i></i> <i></i> 32: 2 144-55.<br/>

http://publicationslist.org/george.loizou/refid22 2010-11-01T10:36:42Z

OBJECTIVE: To investigate whether anticardiolipin (aCL) and anti-beta(2)-glycoprotein I (anti-beta(2)GPI) antibodies are associated with lupus nephritis (group II patients), and whether there are differences in the prevalence of these two autoantibodies between group II patients and patients with non-nephritis SLE (group I) and primary antiphospholipid syndrome (PAPS) patients (group III). METHODS...<br/><br/>S Loizou, M Samarkos, P J Norsworthy, J K Cazabon, M J Walport, K A Davies (2000) <i>Rheumatology (Oxford)</i> <i></i> <i></i> 39: 9 962-8.<br/>

http://publicationslist.org/george.loizou/refid8 2010-11-01T10:36:42Z

George D Loizou, Katherine Jones, Peter Akrill, Delyth Dyne, John Cocker (1999) <i>Toxicology Sciences</i> <i></i> <i></i> 48: 170-179<br/>

http://publicationslist.org/george.loizou/refid4 2010-11-01T10:36:42Z

George D Loizou, Chi Lang Tran, Marion W Anders (1997) <i>Xenobiotica</i> <i></i> <i></i> 27: 1 87-100<br/>

http://publicationslist.org/george.loizou/refid5 2010-11-01T10:36:42Z

George D Loizou (1997) <i>Inhalation Toxicology</i> <i></i> <i>file:///N:/Endnote%20library/References/Loizou%20(1997)%20Inhal%20Toxicol%209%20(781-786).pdf</i> 9: 781-786<br/>

http://publicationslist.org/george.loizou/refid6 2010-11-01T10:36:42Z

G D Loizou, J Cocker (1997) <i></i> <i></i> <i></i> : <br/>

http://publicationslist.org/george.loizou/refid3 2010-11-01T10:36:42Z

George D Loizou, Naji I Eldirdiri, Lawrence J King (1996) <i>Inhalation Toxicology</i> <i></i> <i>file:///N:/Endnote%20library/References/Loizou%20et%20al%20(1996)%20Inhal%20Toxicol%208%20(1-19).pdf</i> 8: 1-19<br/>

http://publicationslist.org/george.loizou/refid2 2010-11-01T10:36:42Z

George D Loizou, Marion W Anders (1995) <i>Drug Metabolism and Disposition</i> <i></i> <i></i> 23: 8 875-880<br/>

http://publicationslist.org/george.loizou/refid1 2010-11-01T10:36:42Z

George. D Loizou, Gudrun Urban, Wolfgang Dekant, Marion W Anders (1994) <i>Drug Metabolism and Disposition</i> <i></i> <i></i> 22: 511-517<br/>

http://publicationslist.org/george.loizou/refid7 2010-11-01T10:36:42Z

George. D Loizou, Marion W Anders (1993) <i>Drug Metabolism and Disposition</i> <i></i> <i></i> 21: 634-639<br/>

http://publicationslist.org/george.loizou/refid9 2010-11-01T10:36:42Z

G D Loizou, P H Redfern (1988) <i>Chronobiology International</i> <i></i> <i></i> 5: 4 331-336<br/>

http://publicationslist.org/george.loizou/refid10 2010-11-01T10:36:42Z

Adenosine 5'-(2-fluorodiphosphate) xD;P2-purinoceptors xD;smooth xD;muscle<br/><br/>S M Hourani, L A Welford, G D Loizou, N J Cusak (1988) <i>European Journal of Pharmacology</i> <i></i> <i></i> 147: 1 131-136<br/>

http://publicationslist.org/george.loizou/refid12 2010-11-01T10:36:42Z

isopolar xD;phosphonate xD;analogues xD;ATP xD;P2-purinoceptors xD;guinea-pig xD;taenia xD;coli xD;urinary xD;bladder<br/><br/>N J Cusak, S M Hourani, G D Loizou, L A Welford (1987) <i>British Journal of Pharmacology</i> <i></i> <i></i> 90: 4 791-795<br/>

http://publicationslist.org/george.loizou/refid11 2010-11-01T10:36:42Z

L-AMP-PCP xD;ATP xD;receptors xD;smooth xD;muscle<br/><br/>S M Hourani, G D Loizou, N J Cusak (1986) <i>European Journal of Pharmacology</i> <i></i> <i></i> 131: 1 99-103<br/>