GIANCESARE GUIDI's Publications List

Relationship between activated partial thromboplastin time, heparin and potassium levels.

2009-02-02T13:28:51Z

Giuseppe Lippi, Gian Cesare Guidi, Massimo Franchini, Emmanuel J Favaloro (2009) Diabetes Res Clin Pract 83: 2 e33-e34

Epidemiological association between fasting plasma glucose and shortened APTT.

2009-02-02T13:28:51Z

OBJECTIVES: To investigate the relationship between fasting plasma glucose (FPG) and shortened activated partial thromboplastin time (APTT), an independent risk factor for thrombosis. DESIGN AND METHODS: We analyzed outpatients' results of coagulation tests and FPG. RESULTS: When compared with euglycemic subjects, those with impaired fasting glucose and diabetes displayed significantly shortened A...

Giuseppe Lippi, Massimo Franchini, Giovanni Targher, Martina Montagnana, Gian Luca Salvagno, Gian Cesare Guidi, Emmanuel J Favaloro (2009) Clin Biochem 42: 1-2 118-120

Continuous glucose monitoring and type 1 diabetes.

2009-02-02T13:28:51Z

Martina Montagnana, Giuseppe Lippi, Gian Cesare Guidi (2009) N Engl J Med 360: 2 190; author reply 191-190; author reply 192

Will "personalized medicine" need personalized laboratory approach?

2009-02-02T13:30:16Z

BACKGROUND: Medicine is evolving on the whole, so laboratory medicine does. Great emphasis is currently presently placed on personalized medicine, particularly by many of the most influential healthcare-linked institutions, communities, organisations and companies. METHODS: Personalized medicine is an appealing terminology, meaning an individualised approach to patients for either diagnosis or tre...

Gian Cesare Guidi, Giuseppe Lippi (2009) Clin Chim Acta 400: 1-2 25-29

Epidemiological association between C-reactive protein and prostate-specific antigen.

2009-02-02T13:28:51Z

Lippi, Montagnana, Guidi (2009) Cancer :

Thrombin generation assay: a useful routine check-up tool in the management of patients with haemophilia?

2009-02-02T13:28:51Z

Severity assessment of patients with haemophilia A (HA) is traditionally based on FVIII activity (FVIII:C). Clinical phenotype of HA patients often differs between individuals with the same FVIII:C determined with clotting and chromogenic assays. The aim of this study was to assess the influence of the FVIII:C on thrombin generation (TG) assay parameters both in vitro and ex-vivo postinfusion plas...

G L Salvagno, J Astermark, G Lippi, M Ekman, M Franchini, G C Guidi, E Berntorp (2009) Haemophilia 15: 1 290-296

The holistic approach to teach laboratory medicine.

2009-02-02T13:51:23Z

Laboratory diagnostics has undergone relevant changes in organization and complexity, providing new opportunities and risks. The skill and expertise required for laboratory professionals to fulfil the need of a continuously evolving scenario in diagnostics embrace now a variety of scientific, managerial and organizational issues. Translating into clinical practice new insights from basic science, ...

Gian Cesare Guidi, Giuseppe Lippi, Mario Plebani (2008) Clin Chim Acta 393: 1 51-53

Doping in competition or doping in sport?

2009-02-02T13:51:23Z

INTRODUCTION: Since ancient times, competitive athletes have been familiar with the use of ergogenic aids and they will probably continue to use unfair and harmful substances in future, because their inclination to victory, along with the mirage of glory and money, will probably overcome health and legal risks. SOURCES OF DATA: We searched PubMed using the term doping over the period 1990 to the p...

Giuseppe Lippi, Massimo Franchini, Gian Cesare Guidi (2008) Br Med Bull 86: 95-107

Plasma gamma-glutamyl transferase activity predicts homocysteine concentration in a large cohort of unselected outpatients.

2009-02-02T13:51:23Z

OBJECTIVE: To evaluate the association between gamma-glutamyl transferase (GGT) and homocysteine in plasma. METHODS: Combined results of GGT, total homocysteine, vitamin B12, folate and creatinine levels were analyzed in outpatients referred for laboratory testing over the past 5 years. RESULTS: Cumulative results for homocysteine, GGT, B12, creatinine, folate could be retrieved for 449 outpatient...

Giuseppe Lippi, Gian Luca Salvagno, Giovanni Targher, Martina Montagnana, Gian Cesare Guidi (2008) Intern Med 47: 8 705-707

Cardiac troponins in pediatric myocarditis.

2009-02-02T13:51:23Z

Giuseppe Lippi, Gian Luca Salvagno, Gian Cesare Guidi (2008) Pediatrics 121: 4 864; author reply 864-864; author reply 865

The power of negative thinking.

2009-02-02T13:51:23Z

Giuseppe Lippi, Gian Cesare Guidi (2008) Am J Emerg Med 26: 3 373-374

Serum pro-inflammatory cytokines in physiological and pre-eclamptic pregnancies.

2009-02-02T13:51:23Z

BACKGROUND: Pre-eclampsia is a heterogeneous syndrome ranging from mild hypertension and proteinuria to severe pre-eclampsia with complications, which can also be associated with an enhanced maternal inflammatory response. METHODS: Tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), interleukin-6 (IL-6) and interferon-gamma (IFN-gamma) were evaluated by multiplexed sandwich enzyme-linke...

Martina Montagnana, Giuseppe Lippi, Alessandro Albiero, Gian Luca Salvagno, Massimo Franchi, Gian Cesare Guidi (2008) Gynecol Endocrinol 24: 3 113-116

The appropriateness of colorectal cancer screening by fecal occult blood tests.

2009-02-02T13:51:23Z

Giuseppe Lippi, Giorgio Brocco, Gian C Guidi (2008) Am J Gastroenterol 103: 3 800-801

Undergraduate education in Laboratory Medicine.

2009-02-02T13:51:23Z

The graduation of medicine is a title necessary but not sufficient to practice the medical profession. In Italy, as in other countries, Laboratory Medicine teaching is an educational area integrated with relevant pre-clinical disciplines, supporting the main medical processes of patient diagnosis, prognosis, treatment monitoring, evolution following-up, risk screening and hidden/latent condition f...

Gian Cesare Guidi, Giuseppe Lippi (2008) Clin Chim Acta 393: 1 9-12

Influence of temperature and time before centrifugation of specimens for routine coagulation testing.

2009-02-02T13:51:23Z

The accurate standardization of the preanalytical phase is of pivotal importance for achieving reliable results of coagulation tests. Because information on the suitable storage conditions for coagulation testing is controversial, we aimed at investigating the sample stability with regard to the temperature and time before centrifugation. The activated partial thromboplastin time (aPTT), prothromb...

Salvagno, Lippi, Montagnana, Franchini, Poli, Guidi (2008) Int J Lab Hematol :

The genetic basis of human athletic performance. Why are psychological components so often overlooked?

2009-02-02T13:51:23Z

Giuseppe Lippi, Emmanuel J Favaloro, Gian Cesare Guidi (2008) J Physiol 586: Pt 12 3017; author reply 3019-3017; author reply 3020

A half-marathon run does not acutely influence lipoprotein(a).

2009-02-02T13:48:02Z

Giuseppe Lippi, Federico Schena, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi (2008) Nutr Metab Cardiovasc Dis 18: 7 e37-e38

Analytical comparison of AxSYM, HemosIL DD HS and Innovance D-dimer immunoassays with the Vidas D-dimer.

2009-02-02T13:48:02Z

Salvagno, Lippi, Manzato, Giavarina, Montagnana, Poli, Guidi (2008) Int J Lab Hematol :

Acute variation of osteocalcin and parathyroid hormone in athletes after running a half-marathon.

2009-02-02T13:48:02Z

Giuseppe Lippi, Federico Schena, Martina Montagnana, Gian Luca Salvagno, Giuseppe Banfi, Gian Cesare Guidi (2008) Clin Chem 54: 6 1093-1095

Glomerular filtration rate in endurance athletes.

2009-02-02T13:48:02Z

OBJECTIVE: The interpretation of biochemical testing in sportsmen requires caution. Although creatinine-based estimates of glomerular filtration rate (GFR) overcome some shortcomings of serum creatinine, there is scarce information on their use in endurance athletes. DESIGN: We evaluated GFR, estimated by the recommended Modification of Diet in Renal Disease (MDRD) equation in athletes. PARTICIPAN...

Giuseppe Lippi, Giuseppe Banfi, Gian Luca Salvagno, Massimo Franchini, Gian Cesare Guidi (2008) Clin J Sport Med 18: 3 286-288

Prevalence and type of pre-analytical problems for inpatients samples in coagulation laboratory.

2009-02-02T13:51:23Z

RATIONALE, AIMS AND OBJECTIVES: Total quality in coagulation testing is a necessary requisite to achieve clinically reliable results. Evidence was provided that poor standardization in the extra-analytical phases of the testing process has the greatest influence on test results, though little information is available so far on prevalence and type of pre-analytical variability in coagulation testin...

Gian L Salvagno, Giuseppe Lippi, Antonella Bassi, Giovanni Poli, Gian C Guidi (2008) J Eval Clin Pract 14: 2 351-353

Air pollution and sports performance in Beijing.

2009-02-02T13:48:02Z

The Beijing Olympics will begin in August 2008 and athletes will face an unpredictable challenge. Based on present data, Beijing is one of the most polluted megacities in the world; the air concentrations of carbon monoxide (CO), ozone, nitrogen oxides (NO and NO2), sulphur dioxide (SO2) and particulate matter approach or exceed the current limits established by U. S. Environmental Protection Agen...

G Lippi, G C Guidi, N Maffulli (2008) Int J Sports Med 29: 8 696-698

Dishomogeneous separation of citrated plasma in primary collection tubes for routine coagulation testing.

2009-02-02T13:51:23Z

Giuseppe Lippi, Gian Luca Salvagno, Antonella Bassi, Martina Montagnana, Giovanni Poli, Gian Cesare Guidi (2008) Blood Coagul Fibrinolysis 19: 4 330-332

Quality improvement in laboratory medicine: extra-analytical issues.

2009-02-02T13:51:23Z

This article addresses sources of error in the pre- and postanalytic phases of the testing cycle, using the collection of blood specimens as a paradigm for quality improvement in these phases of testing. The article focuses on appropriateness of the test request, patient and sample identification, criteria for acceptance and rejection of specimens, and the communication and interpretation of resul...

Giuseppe Lippi, Roberto Fostini, Gian Cesare Guidi (2008) Clin Lab Med 28: 2 285-94, vii

Reference ranges and diagnostic thresholds of laboratory markers of cardiac damage and dysfunction in a population of apparently healthy black Africans.

2009-02-02T13:51:23Z

Abstract Background: Due to the increasing migration flows mostly concerning Western countries, the problem of reference ranges and cut-off values is a living matter. In particular, the influence of ethnic origin on traditional and novel biochemical markers of cardiac damage, including cardiac troponin T (cTnT), ischemia modified albumin (IMA) and N-terminal prohormone brain natriuretic peptide (N...

Montagnana, Lippi, Salvagno, Guidi (2008) Clin Chem Lab Med :

Inherited platelet disorders.

2009-02-02T13:51:23Z

Inherited platelet disorders are a rare, but probably underdiagnosed, cause of symptomatic bleeding. They are characterized by abnormalities of platelet number (inherited thrombocytopenias), function (inherited disorders of platelet function) or both. This review briefly discusses the inherited platelet disorders with respect to molecular defects, diagnostic evaluation and treatment strategies.

Massimo Franchini, Giuseppe Lippi, Dino Veneri, Giovanni Targher, Marco Zaffanello, Gian Cesare Guidi (2008) Clin Chim Acta 387: 1-2 1-8

Is estimated glomerular filtration rate suitable for stratification of chronic kidney disease?

2009-02-02T13:51:23Z

G Lippi, G L Salvagno, G C Guidi (2008) Scand J Clin Lab Invest 68: 3 254-255

The growing trend of scientific interest in sports science research.

2009-02-02T13:51:23Z

Giuseppe Lippi, Gian Cesare Guidi, Alan Nevill, Colin Boreham (2008) J Sports Sci 26: 1 1-2

Correlation between von Willebrand factor antigen, von Willebrand factor ristocetin cofactor activity and factor VIII activity in plasma.

2009-02-02T13:54:23Z

BACKGROUND: The laboratory diagnosis of von Willebrand Factor (VWF) deficiencies includes qualitative and quantitative measurements of VWF and clotting factor VIII (FVIII). Since the FVIII activity is frequently normal in patients with mild type 1 or 2 von Willebrand disease (VWD), there is controversy whether FVIII testing should accompany VWF Antigen (VWF:Ag) assay. METHODS: The aim of this stud...

Giuseppe Lippi, Massimo Franchini, Gian Luca Salvagno, Martina Montagnana, Giovanni Poli, Gian Cesare Guidi (2008) J Thromb Thrombolysis 26: 2 150-153

Higher morning serum cortisol level predicts increased fibrinogen but not shortened APTT.

2009-02-02T13:54:23Z

BACKGROUND: There is emerging evidence that serum cortisol might be independently associated with prothrombotic activity, suggesting that increased cortisol levels might finally contribute to the pathogenesis of atherosclerotic disorders. Since hypercoagulability is principally sustained by either defective naturally occurring anticoagulant mechanisms or to heightened coagulation factors, most of ...

Giuseppe Lippi, Massimo Franchini, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi (2008) J Thromb Thrombolysis 26: 2 103-105

Diagnostic value of D-dimer measurement in patients referred to the emergency department with suspected myocardial ischemia.

2009-02-02T13:54:23Z

BACKGROUND: The accurate identification of patients with acute myocardial infarction (AMI) remains one of the most difficult challenges facing emergency physicians. The introduction of early and reliable biomarkers of AMI should hence be acknowledged, since they would increase the efficiency of the diagnostic process. METHODS: A total of 2,276 consecutive patients referred to the emergency departm...

Giuseppe Lippi, Luca Filippozzi, Martina Montagnana, Gian Luca Salvagno, Gian Cesare Guidi (2008) J Thromb Thrombolysis 25: 3 247-250

Glycaemic control in athletes.

2009-02-02T13:54:23Z

Physical activity is essential for weight control, for limiting onset and complications of chronic disorders and for preventing impaired insulin sensitivity. Little is known about the glycaemic adaptations of physically active subjects, especially elite and professional athletes. Thus, we evaluated the glycaemic control in elite and professional cyclists by assessing fasting plasma glucose (FPG) a...

G Lippi, M Montagnana, G L Salvagno, M Franchini, G C Guidi (2008) Int J Sports Med 29: 1 7-10

Relationship between von Willebrand factor, cholesterol and triglycerides in non-diabetic subjects.

2009-02-02T13:51:23Z

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi, Giovanni Targher, Massimo Franchini (2008) Nutr Metab Cardiovasc Dis 18: 2 e3-e4

The erythrocyte mean corpuscular volume is associated with serum levels of thyroid stimulating hormone in women.

2009-02-02T13:51:23Z

Martina Montagnana, Giuseppe Lippi, Massimo Franchini, Gian Cesare Guidi (2008) Am J Hematol 83: 3

The use of recombinant activated factor VII in platelet-associated bleeding.

2009-02-02T13:48:02Z

Recombinant activated factor VII (rFVIIa) was originally developed for the treatment of spontaneous and surgical bleeding of hemophiliacs with inhibitors. Along with the elucidation of its molecular mechanism of action, rFVIIa has been successfully used over the last few years in a wide range of non-hemophilic bleeding conditions. The aim of this review is to summarize the current clinical experie...

Massimo Franchini, Giuseppe Lippi, Gian Cesare Guidi (2008) Hematology 13: 1 41-45

Relationship between serum vitamin D and inflammatory markers in the general population: comment on the article by Patel et al.

2009-02-02T13:51:23Z

Giuseppe Lippi, Martina Montagnana, Giovanni Targher, Gian Cesare Guidi (2008) Arthritis Rheum 58: 3 913-914

Comment on effects of microwave cooking conditions on bioactive compounds present in broccoli inflorescences.

2009-02-02T13:51:23Z

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi (2008) J Agric Food Chem 56: 6

Relationship between thyroid status and renal function in a general population of unselected outpatients.

2009-02-02T13:51:23Z

OBJECTIVE: To investigate the relationship between thyroid and kidney function. DESIGN AND METHODS: 13,383 results of serum creatinine and thyroid stimulating hormone (TSH) were retrieved from the database of our Laboratory. RESULTS: When compared with euthyroid subjects, those with TSH <0.2 mIU/L and >2.5 mIU/L had increased and decreased estimated glomerular filtration rate (e-GFR), respectively...

Giuseppe Lippi, Martina Montagnana, Giovanni Targher, Gian Luca Salvagno, Gian Cesare Guidi (2008) Clin Biochem 41: 7-8 625-627

New strategies for doping control.

2009-02-02T13:51:23Z

Doping in sports is commonplace. The prevention of harm to the athlete, the guarantee of fair play, and a level playing field for all competitors are the basis of the current anti-doping strategies. As healthcare systems are forced to allocate increasing resources to prevent and treat the prevailing pathologies worldwide, funding for anti-doping campaigns will necessarily be restricted. Ideally, a...

Giuseppe Lippi, Giuseppe Banfi, Massimo Franchini, Gian Cesare Guidi (2008) J Sports Sci 26: 5 441-445

Influence of sampling time and ultrafiltration coefficient of the dialysis membrane on cardiac troponin I and T.

2009-02-02T13:51:23Z

CONTEXT: The measurement of cardiac troponin I (TnI) and T (TnT) is essential to diagnose, guide therapy, and predict outcomes of the acute coronary syndrome. Increased levels of troponins, especially TnT, are frequently observed in patients on chronic hemodialysis (HD), reflecting ongoing and subclinical myocardial damage. OBJECTIVE: Because these markers are increasingly used for stratification ...

Giuseppe Lippi, Nicola Tessitore, Martina Montagnana, Gian Luca Salvagno, Antonio Lupo, Gian Cesare Guidi (2008) Arch Pathol Lab Med 132: 1 72-76

Effect of hemodialysis on traditional and innovative cardiac markers.

2009-02-02T13:51:23Z

The diagnostic approach to acute coronary syndrome (ACS) is challenging in patients with impaired renal function since most serum biomarkers are commonly increased in this clinical setting. Cardiac troponin T (cTnT), creatine kinase isoenzyme MB (CK MB), myoglobin, and ischemia modified albumin (IMA), were assayed in 45 patients prehemodialysis (pre-HD) and posthemodialysis (post-HD), and results ...

Martina Montagnana, Giuseppe Lippi, Nicola Tessitore, Gian Luca Salvagno, Giovanni Targher, Matteo Gelati, Antonio Lupo, Gian Cesare Guidi (2008) J Clin Lab Anal 22: 1 59-65

Should women with abnormal serum thyroid stimulating hormone undergo screening for anemia?

2009-02-02T13:51:23Z

Giuseppe Lippi, Martina Montagnana, Gian Luca Salvagno, Gian Cesare Guidi (2008) Arch Pathol Lab Med 132: 3 321-322

Inherited and acquired risk factors for arterial ischemic stroke in childhood.

2009-02-02T13:51:23Z

Ischemic stroke in childhood is a rare but serious disorder, which is associated with significant morbidity and mortality. The lack of causal homogeneity in the aetiology of this disorder presents problems for predicting and preventing it, making the ischemic stroke in childhood a real dilemma for the clinician. Although a variety of potential inherited and acquired causes have been now identified...

Lippi, Franchini, Montagnana, Salvagno, Targher, Guidi (2008) J Thromb Thrombolysis :

Evaluating endothelial function of the common carotid artery: An in vivo human model.

2009-02-02T13:30:16Z

BACKGROUND AND AIMS: Flow mediated dilation (FMD) of peripheral conduit arteries is a well-established tool to evaluate endothelial function. The aims of this study are to apply the FMD model to cerebral circulation by using acetazolamide (ACZ)-induced intracranial vasodilation as a stimulus to increase common carotid artery (CCA) diameter in response to a local increase of blood flow velocity (BF...

Mazzucco, Bifari, Trombetta, Guidi, Mazzi, Anzola, Rizzuto, Bonadonna (2008) Nutr Metab Cardiovasc Dis :

Performance of the automated and rapid HemosIL D-Dimer HS on the ACL TOP analyzer.

2009-02-02T13:28:51Z

We evaluated the analytical performance of the new commercial HemosIL D-Dimer HS, a latex-enhanced turbidimetric immunoassay, from Instrumentation Laboratory for D-dimer measurement on the ACL TOP automated analyzer. The recommended cut-off for this immunoassay is 243 ng/ml. The within-run and between-run coefficients of variations of D-Dimer HS for low, intermediate and high D-dimer concentration...

Gian L Salvagno, Giuseppe Lippi, Martina Montagnana, Giovanni Poli, Davide Giavarina, Franco Manzato, Gian C Guidi (2008) Blood Coagul Fibrinolysis 19: 8 817-821

Salbutamol in athletes.

2009-02-02T13:30:16Z

Giuseppe Lippi, Massimo Franchini, Emmanuel J Favaloro, Gian Cesare Guidi (2008) Clin J Sport Med 18: 5 469; author reply 469-469; author reply 470

Comments on Lundby et al.'s "testing for recombinant human erythropoietin in urine: problems associated with current anti-doping testing". Problems associated with current anti-doping testing: is quality assessment a reliable solution?

2009-02-02T13:28:51Z

Gian Luca Salvagno, Gian Cesare Guidi (2008) J Appl Physiol 105: 6 1992-3; author reply 1997-8

Hyperthyroidism is associated with shortened APTT and increased fibrinogen values in a general population of unselected outpatients.

2009-02-02T13:30:56Z

Although clinical evidence supports a plausible association between thyroid disorders and venous thrombosis, reliable evidence is so far lacking on the potential biological mechanisms and neither temporary nor permanent thromboembolic risk factors were constantly identified. We performed a 2-years retrospective analysis to retrieve combined results of activated partial thromboplastin time (APTT), ...

Lippi, Franchini, Targher, Montagnana, Salvagno, Guidi, Favaloro (2008) J Thromb Thrombolysis :

Estimation of glomerular filtration rate by the modification of diet in renal disease (MDRD) equation in patients with sickle cell disease.

2009-02-02T13:30:56Z

Giuseppe Lippi, Lucia De Franceschi, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi (2008) Clin Chem Lab Med 46: 8 1200-1201

High serum uric acid as a novel risk factor for type 2 diabetes: response to Dehghan et al.

2009-02-02T13:30:56Z

Giuseppe Lippi, Giovanni Targher, Martina Montagnana, Gian Luca Salvagno, Gian Cesare Guidi (2008) Diabetes Care 31: 9

Relationship between hypomagnesemia and glucose homeostasis.

2009-02-02T13:30:56Z

BACKGROUND: Controversial data are available on the relationship between magnesium metabolism and glucose homeostasis. METHODS: We performed a retrospective analysis to retrieve results of serum magnesium and fasting plasma glucose (FPG) tests (7,659 outpatients >35 years old). RESULTS: Subjects with FPG value > 7.0 mmol/L were more likely to had hypomagnesemia. The frequency of hypomagnesemia was...

Martina Montagnana, Giuseppe Lippi, Giovanni Targher, Gian Luca Salvagno, Gian Cesare Guidi (2008) Clin Lab 54: 5-6 169-172

Dark chocolate: consumption for pleasure or therapy?

2009-02-02T13:30:16Z

Traditional chocolate is derived from the cocoa bean, which is one of the most concentrated sources of flavanols, a subgroup of the natural antioxidant plant compounds called flavonoids. Accumulating evidence from the past 10 years demonstrates that moderate consumption of chocolate, especially dark chocolate, may exert protective effects against the development of cardiovascular disease. Several ...

Lippi, Franchini, Montagnana, Favaloro, Guidi, Targher (2008) J Thromb Thrombolysis :

Separation of haemoglobin HbE and HbA by the fully automated, high-pressure liquid chromatography Tosoh HLC-723 G7 analyzer.

2009-02-02T13:28:51Z

High-pressure liquid chromatography instruments specifically devised for separating haemoglobin (Hb) fractions have been increasingly employed by the hospital laboratories over the recent years since they allow easy and fast screening for several Hb variants. Although such instruments may be proposed as sensitive, specific and reliable alternatives to the classic electrophoretic techniques, a majo...

G Lippi, M R Carta, G L Salvagno, F Bellorio, M Montagnana, G Soffiati, G C Guidi (2008) Int J Lab Hematol 30: 5 432-436

Appropriateness of statistical analysis for evaluating results of lipoprotein(a) testing.

2009-02-02T13:30:16Z

Giuseppe Lippi, Gian Cesare Guidi (2008) Int J Dermatol 47: 9

Influence of a half-marathon run on NT-proBNP and troponin T.

2009-02-02T13:30:16Z

BACKGROUND: A caveat to strenuous and medium term physical exercise is the potential cardiovascular damage it may cause. In particular, there is still controversy regarding the behaviour of biochemical markers of heart damage and dysfunction following medium term endurance training. METHODS: Troponin T (TnT) and the N-terminal proB-type natriuretic peptide (NT-proBNP) were assessed before a 21-km ...

Giuseppe Lippi, Federico Schena, Gian Luca Salvagno, Martina Montagnana, Matteo Gelati, Cantor Tarperi, Giuseppe Banfi, Gian Cesare Guidi (2008) Clin Lab 54: 7-8 251-254

The potential contribution of laboratory biomarkers to the diagnosis of pulmonary embolism.

2009-02-02T13:48:02Z

Giuseppe Lippi, Martina Montagnana, Gian Cesare Guidi (2008) Am J Emerg Med 26: 5 624-625

Reference ranges and diagnostic thresholds of laboratory markers of cardiac damage and dysfunction in a population of apparently healthy black Africans.

2009-02-02T13:30:16Z

BACKGROUND: Due to the increasing migration flows mostly concerning Western countries, the problem of reference ranges and cut-off values is a living matter. In particular, the influence of ethnic origin on traditional and novel biochemical markers of cardiac damage, including cardiac troponin T (cTnT), ischemia modified albumin (IMA) and N-terminal prohormone brain natriuretic peptide (NT-proBNP)...

Martina Montagnana, Giuseppe Lippi, Gian Luca Salvagno, Gian Cesare Guidi (2008) Clin Chem Lab Med 46: 5 714-716

Acute influence of aerobic physical exercise on procalcitonin.

2009-02-02T13:30:16Z

G Lippi, F Schena, M Montagnana, G L Salvagno, G C Guidi (2008) Eur J Clin Invest 38: 10 784-785

Influence of stable, long-term treatment with phenobarbital on the activity of serum alanine aminotransferase and gamma-glutamyltransferase.

2009-02-02T13:30:16Z

Phenobarbital, a long-acting barbiturate, is generally considered to be a fairly safe and effective drug; however, hepatotoxicity is an infrequent but potentially fatal adverse effect and there is little information on the serum activity of liver enzymes in patients on stable, long-term monotherapy. The serum activity of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) are measur...

G Lippi, M Montagnana, G L Salvagno, G C Guidi (2008) Br J Biomed Sci 65: 3 132-135

Detecting of chronic kidney disease in older people by the MDRD and MCQ formulas.

2009-02-02T13:30:16Z

Giuseppe Lippi, Giovanni Targher, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi (2008) Age Ageing 37: 6

Non-homogeneous separation of triglycerides, gamma-glutamyltransferase, C-reactive protein and lactate dehydrogenase after centrifugation of lithium-heparin tubes.

2009-02-02T13:30:56Z

BACKGROUND: Clinical chemistry testing is influenced by a variety of preanalytical variables, including sample preparation. The presence of a diluted plasma layer at the top of primary tubes containing plasma citrate has recently been reported. However, no indication is available so far on the potential non-homogeneous distribution of clinical chemistry analytes during centrifugation of primary tu...

Gian Luca Salvagno, Giuseppe Lippi, Martina Montagnana, Giorgio Brocco, Gian Cesare Guidi (2008) Clin Chem Lab Med 46: 8 1180-1182

No correlation between lipoprotein(a) and biochemical markers of renal function in the general population.

2009-02-02T13:30:56Z

CONTEXT: Lipoprotein(a) (Lp(a)) is receiving major emphasis as an independent risk factor for cardiovascular disease. Results of studies on Lp(a) in patients with impaired renal function are contradictory, and no information is available on the association between Lp(a) and estimated glomerular filtration rate and cystatin C. OBJECTIVE: To evaluate the potential relationships among the biochemical...

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Giovanni Targher, Massimo Franchini, Gian Cesare Guidi (2008) Arch Pathol Lab Med 132: 9 1436-1438

Standards of practice and uniformity in references style.

2009-02-02T13:33:05Z

Authors are usually invited to follow the instructions to authors in scientific journals, because this section is likely to contain unique requirements, such as the references style requested. Authors not only must accurately check the instructions, but are also expected to verify references against the original documents before submitting the article, consuming a considerable amount of time. This...

Gian Luca Salvagno, Giuseppe Lippi, Martina Montagnana, Gian Cesare Guidi (2008) Clin Chem Lab Med 46: 4 437-438

Hyperuricaemia is associated with increased C-reactive protein concentrations in a large cohort of unselected outpatients.

2009-02-02T13:30:56Z

Giuseppe Lippi, Giovanni Targher, Martina Montagnana, Gian Luca Salvagno, Gian Cesare Guidi (2008) Nutr Metab Cardiovasc Dis 18: 8 e41-e42

Acute variation of biochemical markers of muscle damage following a 21-km, half-marathon run.

2009-02-02T13:33:05Z

Objective. Although there is information on biochemical markers of muscle and cardiac damage following strenuous exercise, little is known about the kinetics of these markers in athletes performing sub-maximal exercise. Material and methods. Fifteen healthy, trained, Caucasian males took part in a 21-km run. Blood samples were collected before the run, immediately after (post), and 3 h, 6 h and 24...

G Lippi, F Schena, G L Salvagno, M Montagnana, M Gelati, C Tarperi, G Banfi, G C Guidi (2008) Scand J Clin Lab Invest 68: 7 667-672

Acute variation of estimated glomerular filtration rate following a half-marathon run.

2009-02-02T13:33:05Z

The accurate estimation of glomerular filtration rate (GFR) is pivotal in sports medicine. However, there is controversial information on the acute influence of physical exercise on kidney function in healthy athletes. The estimated GFR (EGFR) was assessed by the recommended Modification of Diet in Renal Disease (MDRD) equation before a 21-km half-marathon, at the end, and 3, 6, 24 hrs thereafter ...

G Lippi, F Schena, G L Salvagno, C Tarperi, M Montagnana, M Gelati, G Banfi, G C Guidi (2008) Int J Sports Med 29: 12 948-951

Uric acid concentration in patient with acute coronary syndrome.

2009-02-02T13:48:02Z

Giuseppe Lippi, Martina Montagnana, Massimo Franchini, Gian Cesare Guidi, Giovanni Targher (2008) Intern Emerg Med 3: 4 409-411

Glucose challenge test does not predict gestational diabetes mellitus.

2009-02-02T13:48:02Z

OBJECTIVE: It is widely acknowledged that identification and treatment of gestational diabetes mellitus (GDM) results in better maternal and neonatal outcomes. However, the utility of the glucose challenge test (GCT) remains controversial regarding the diagnostic approach and decision making. METHODS: We performed a retrospective analysis on the database of our Laboratory Information System to ret...

Martina Montagnana, Giuseppe Lippi, Giovanni Targher, Cristiano Fava, Gian Cesare Guidi (2008) Intern Med 47: 13 1171-1174

Role of biochemical risk factors and markers for the risk of atherosclerosis

2009-02-02T13:33:05Z

The prevalence of atherosclerotic cardiovascular disorders is constantly increasing worldwide, and the aging of the population will make this trend rather unlikely to be reversed. It is a diffuse, systemic, chronic disorder that starts early in childhood and progresses asymptomatically throughout the adult life. Later in life, it is clinically manifested as coronary artery disease, stroke, transie...

Martina Montagnana, Giuseppe Lippi, Gian Luca Salvagno, Massimo Franchini, Giovanni Targher, Gian Cesare Guidi (2008) Recenti Prog Med 99: 4 215-222

Eosinophilia and first-line coagulation testing.

2009-02-02T13:33:05Z

Although eosinophilia (eosinophil count >0.60 x 10(9)/l), is a prothrombotic condition, little is known on the association between eosinophil count in blood and first-line coagulations tests, including fibrinogen, activated partial thromboplastin time (APTT), prothrombin time (PT) and platelet count. Cumulative results of APTT, PT, fibrinogen, platelet and eosinophil counts were retrieved from 6,9...

Lippi, Montagnana, Salvagno, Franchini, Targher, Guidi (2008) J Thromb Thrombolysis :

The red blood cell distribution width is associated with serum levels of thyroid stimulating hormone in the general population.

2009-02-02T13:33:05Z

Montagnana, Lippi, Targher, Salvagno, Guidi (2008) Int J Lab Hematol :

Influence of acute physical exercise on emerging muscular biomarkers.

2009-02-02T13:33:05Z

BACKGROUND: Although there is comprehensive information on traditional biomarkers of muscle and cardiac damage following exercise, less is known on the kinetics of innovative markers, including ischemia modified albumin (IMA), glycogen phosphorylase isoenzyme BB (GPBB), carbonic anhydrase III (CAIII) and heart-type fatty acid-binding protein (H-FABP) in athletes performing a sub-maximal exercise. ...

Giuseppe Lippi, Federico Schena, Martina Montagnana, Gian Luca Salvagno, Gian Cesare Guidi (2008) Clin Chem Lab Med 46: 9 1313-1318

Bilirubin concentration and cardiovascular risk profile.

2009-02-02T13:30:56Z

Lippi, Targher, Montagnana, Salvagno, Guidi (2008) Liver Int :

Sudden cardiac death in young athletes.

2009-02-02T13:30:56Z

Although regular aerobic physical activity increases exercise capacity and plays a role in both primary and secondary prevention of a variety of chronic disorders, competitive physical exercise is associated with a significant increase of risk of sudden death in athletes, especially adolescents and young adults. Several pathogenetic mechanisms have been speculated, including silent cardiovascular ...

Martina Montagnana, Giuseppe Lippi, Massimo Franchini, Giuseppe Banfi, Gian Cesare Guidi (2008) Intern Med 47: 15 1373-1378

Acute kidney injury: time to shift from creatinine to the estimated glomerular filtration rate?

2009-02-02T13:30:56Z

Giuseppe Lippi, Gian Cesare Guidi (2008) Crit Care 12: 4

Relationship between red blood cell distribution width and kidney function tests in a large cohort of unselected outpatients.

2009-02-02T13:33:05Z

OBJECTIVE: A strong, independent, association has recently been shown between higher red blood cell distribution width (RDW) and the risk of all-cause death and cardiovascular events. However, the mechanism(s) underlying this association remains unclear. Since impaired kidney function is a well-known risk factor for cardiovascular disease, we assessed whether RDW is associated with decreased kidne...

Giuseppe Lippi, Giovanni Targher, Martina Montagnana, Gian Luca Salvagno, Giacomo Zoppini, Gian Cesare Guidi (2008) Scand J Clin Lab Invest 68: 8 745-748

Prevalence of folic Acid and vitamin B12 deficiencies in patients with thyroid disorders.

2009-02-02T13:33:05Z

Although macrocytosis might occur with frequency in patients with thyroid disorders, there is controversial information on the metabolic relationship between thyroid stimulating hormone (TSH), folic acid and B12 in the general population. We performed a retrospective analysis to retrieve results of serum folic acid, B12, and TSH performed on consecutive outpatients referred by general practitioner...

Giuseppe Lippi, Martina Montagnana, Giovanni Targher, Gian Luca Salvagno, Gian Cesare Guidi (2008) Am J Med Sci 336: 1 50-52

Air pollution and coagulation testing: a new source of biological variability?

2009-02-02T13:48:02Z

Preanalytical and biological variability both have strong influences on test results of coagulation. Beyond age and gender, increasing emphasis is now being given to a variety of demographic and lifestyle variables, including ethnicity, smoking, diet, and exercise, which should be taken into account when interpreting laboratory data. However, there is strong emerging evidence that additional envir...

Giuseppe Lippi, Emmanuel J Favaloro, Massimo Franchini, Gian Cesare Guidi (2008) Thromb Res 123: 1 50-54

Procalcitonin values in preeclamptic women are related to severity of disease.

2009-02-02T13:33:05Z

Martina Montagnana, Giuseppe Lippi, Alessandro Albiero, Silvia Scevarolli, Gian Luca Salvagno, Massimo Franchi, Gian Cesare Guidi (2008) Clin Chem Lab Med 46: 7 1050-1051

Risk stratification of patients with acute myocardial infarction by quantification of circulating monocyte-platelet aggregates.

2009-02-02T13:57:51Z

Giuseppe Lippi, Martina Montagnana, Gian Luca Salvagno, Nicola Cicorella, Maurizio Degan, Piero Minuz, Clara Lechi, Gian Cesare Guidi (2007) Int J Cardiol 115: 1 101-102

Increased D-dimer value and occult cancer in the absence of detectable thrombosis.

2009-02-02T13:54:23Z

Fibrin formation and removal occurs continuously during the development of malignancy. Accordingly, hemostatic disorders in cancer patients are a rather frequent observation and range from asymptomatic laboratory changes to massive thromboembolism or haemorrhage. We document the case of an asymptomatic women, who was enrolled as a healthy control in a study and showed up with a substantially incre...

G Lippi, M Franchini, C Biasiutti, G Dellagiacoma, G L Salvagno, G C Guidi (2007) Haematologica 92: 4 e53-e55

Ginkgo biloba, inflammation and lipoprotein(a).

2009-02-02T13:54:23Z

Giuseppe Lippi, Giovanni Targher, Gian Cesare Guidi (2007) Atherosclerosis 195: 2 417-8; author reply 419-22

Tour de chaos.

2009-02-02T13:54:23Z

Giuseppe Lippi, Massimo Franchini, Gian Cesare Guidi (2007) Br J Sports Med 41: 10 625-6; discussion 626

PON1 activity and genotype in patients with arterial ischemic stroke and in healthy individuals.

2009-02-02T13:54:23Z

OBJECTIVE: Paraoxonase-1 (PON1) is an esterase with antioxidant properties. Low PON1 enzyme activity or specific allelic polymorphisms seem to be associated with the risk of developing coronary artery disease or acute ischemic stroke (AIS). Our objective was to determine the distribution of both PON1 enzyme activity and its genotype in a group of patients with AIS. MATERIALS AND METHODS: PON1 acti...

R Schiavon, M Turazzini, E De Fanti, P Battaglia, L Targa, R Del Colle, A Fasolin, M Silvestri, S Biasioli, G Guidi (2007) Acta Neurol Scand 116: 1 26-30

Relationship between gamma-glutamyltransferase, lipids and lipoprotein(a) in the general population.

2009-02-02T13:54:23Z

BACKGROUND: Population-based epidemiological studies have shown a convincing association between increased gamma-glutamyltransferase (GGT) activity and components of the metabolic syndrome, type 2 diabetes, hypertension, ischaemic stroke and myocardial infarction. However, little information is available on the interaction between GGT activity and traditional or emerging markers of cardiovascular ...

Giuseppe Lippi, Giovanni Targher, Martina Montagnana, Gian Luca Salvagno, Gian Cesare Guidi (2007) Clin Chim Acta 384: 1-2 163-166

The paradox in translational medicine.

2009-02-02T13:54:23Z

Giuseppe Lippi, Mario Plebani, Gian Cesare Guidi (2007) Clin Chem 53: 8

Influence of the centrifuge time of primary plasma tubes on routine coagulation testing.

2009-02-02T13:54:23Z

Preparation of blood specimens is a major bottleneck in the laboratory throughput. Reliable strategies for reducing the time required for specimen processing without affecting quality should be acknowledged, especially for laboratories performing stat analyses. The present investigation was planned to establish a minimal suitable centrifuge time for primary samples collected for routine coagulatio...

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Franco Manzato, Gian Cesare Guidi (2007) Blood Coagul Fibrinolysis 18: 5 525-528

One hundred years of laboratory testing and patient safety.

2009-02-02T13:54:23Z

Giuseppe Lippi, Gian Cesare Guidi, Mario Plebani (2007) Clin Chem Lab Med 45: 6 797-798

Risk management in the preanalytical phase of laboratory testing.

2009-02-02T13:54:23Z

The clinical laboratory is no longer its own limited ecosystem, as it is increasingly integrated with patient care, assisting diagnosis, monitoring therapies and predicting clinical outcomes. Although efforts and resources are continuously focused to achieve a satisfactory degree of analytical quality, there is clear evidence that the preanalytical phase is much more vulnerable to uncertainties an...

Giuseppe Lippi, Gian Cesare Guidi (2007) Clin Chem Lab Med 45: 6 720-727

New frontiers in noninvasive, prenatal screening and diagnosis: fetal DNA circulating in maternal blood

2009-02-02T13:54:23Z

Prenatal diagnosis is aimed to provide reliable clinical information to parents and physician on the risk of having babies affected by inherited anomalies or genetic disorders. Placenta is not a barrier between the pregnant woman and her genetically different fetus, but it is the centre of a complex bidirectional transfer. The discovery of circulating fetal DNA in maternal blood has disclosed new ...

M Montagnana, G Lippi, G C Guidi (2007) Minerva Ginecol 59: 3 331-341

The functional variant of the CLC-Kb channel T481S is not associated with blood pressure or hypertension in Swedes.

2009-02-02T13:54:23Z

OBJECTIVE: A common threonine481serine polymorphism (T481S) has been shown in vitro to strongly activate the chloride channel Kb (CLC-Kb) expressed in the kidney, and the 481S allele has been associated with human hypertension. The study aim was to evaluate the association of the T481S polymorphism with blood pressure (BP) levels and the BP progression rate in Swedes. DESIGN AND METHODS: The cardi...

Cristiano Fava, Martina Montagnana, Peter Almgren, Lena Rosberg, Gian Cesare Guidi, Göran Berglund, Olle Melander (2007) J Hypertens 25: 1 111-116

Novel mutations in the SLC12A3 gene causing Gitelman's syndrome in Swedes.

2009-02-02T13:54:23Z

PURPOSE: Gitelman's syndrome (GS) is an inherited autosomal recessive disorder due to loss of function mutations in the SLC12A3 gene encoding the Na-Cl co-transporter (NCCT), the target of thiazide diuretics. The defective function of the NCCT, which normally is expressed in the apical membrane of the distal convolute tubule in the kidney, leads to mild hypotension, hypokalemia, hyperreninemic hyp...

Cristiano Fava, Martina Montagnana, Lena Rosberg, Philippe Burri, Anders Jönsson, Pär Wanby, Hans Wahrenberg, U Lennart Hulthén, Mattias Aurell, Gian Cesare Guidi, Olle Melander (2007) DNA Seq 18: 5 395-399

Measurement of Elecsys NT-proBNP in serum, K2 EDTA and heparin plasma.

2009-02-02T13:54:23Z

OBJECTIVE: There is controversial evidence on a matrix influence on the measurement of NT-proBNP. DESIGN AND METHODS: We compared results of Elecsys NT-proBNP measurement on serum, K2 EDTA plasma and lithium heparin plasma. RESULTS: Samples collected in K2 EDTA showed a marginally significant underestimation when compared to serum and heparin, whereas no significant difference was observed between...

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi (2007) Clin Biochem 40: 9-10 747-748

Lipoprotein(a), athero-thrombosis and longevity. A historical paradox finally elucidated?

2009-02-02T13:54:23Z

Giuseppe Lippi, Massimo Franchini, Gian Cesare Guidi (2007) Haematologica 92: 4

Standardization of ischemia-modified albumin testing: adjustment for serum albumin.

2009-02-02T13:54:23Z

Giuseppe Lippi, Martina Montagnana, Gian Luca Salvagno, Gian Cesare Guidi (2007) Clin Chem Lab Med 45: 2 261-262

Diagnostic approach to inherited bleeding disorders.

2009-02-02T13:54:23Z

The appropriate development of hemostasis encompasses a delicate equilibrium between anti- and prothrombotic forces developing during three distinct phases (primary hemostasis, coagulation and fibrinolysis) that are closely linked to each other and precisely regulated to close vessel wounds, promote vascular healing and maintain vessel patency. Imbalance in each of these systems produces either he...

Giuseppe Lippi, Massimo Franchini, Gian Cesare Guidi (2007) Clin Chem Lab Med 45: 1 2-12

Impact of different inhibitor reactivities with commercial factor VIII concentrates on thrombin generation.

2009-02-02T13:54:23Z

In order to describe the haemostatic role of a variation in inhibitor reactivity with different factor VIII (FVIII) concentrates, we have compared inhibitor titres against a panel of FVIII concentrates and correlated titre with the capacity to inhibit thrombin generation. Three plasma-derived concentrates were tested in vitro in mixing experiments with inhibitor plasmas from 11 patients with sever...

G L Salvagno, J Astermark, M Ekman, M Franchini, G C Guidi, G Lippi, G Poli, E Berntorp (2007) Haemophilia 13: 1 51-56

The significance of evaluating conventional inflammatory markers in Von Willebrand factor measurement.

2009-02-02T13:54:23Z

BACKGROUND: The appropriate clinical interpretation of Von Willebrand factor (VWF) measurements is crucial since inherited or acquired deficiencies are responsible for a potentially life threatening bleeding disorder, whereas increased plasma concentrations may be associated with an increased thrombotic risk. Besides age and blood group, the variability introduced by the presence of an acute phase...

Giuseppe Lippi, Massimo Franchini, Giovanni Targher, Giovanni Poli, Gian Cesare Guidi (2007) Clin Chim Acta 381: 2 167-170

Multiple biomarkers for the prediction of first major cardiovascular events and death: considerable costs and limited benefits.

2009-02-02T13:54:23Z

Giuseppe Lippi, Gian Luca Salvagno, Giovanni Targher, Gian Cesare Guidi (2007) MedGenMed 9: 1

How many troponins should we measure to get a clinically significant result?

2009-02-02T13:54:23Z

G Lippi, G L Salvagno, M Montagnana, G C Guidi (2007) QJM 100: 6 389-390

Routine coagulation tests in newborn and young infants.

2009-02-02T13:54:23Z

BACKGROUND: The diagnostic approach to haemostatic defects in the newborn is challenging and requires appropriate interpretation of coagulation tests according to reference values dependent on the postnatal age. METHODS: This investigation was designed to study the postnatal development of the human coagulation system in newborn infants and to develop appropriate reference ranges for prothrombin t...

Giuseppe Lippi, Gian Luca Salvagno, Simone Rugolotto, Gian Paolo Chiaffoni, Ezio Maria Padovani, Massimo Franchini, Gian Cesare Guidi (2007) J Thromb Thrombolysis 24: 2 153-155

Relationship between matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases systems and autoantibody patterns in systemic sclerosis.

2009-02-02T13:54:23Z

OBJECTIVE: Systemic sclerosis (SSc) is a connective tissue disease characterized by tissue fibrosis that reflects an imbalance between collagen production and degradation. Matrix metalloproteinases (MMPs) are a family of endopeptidases involved in the remodelling of extracellular matrix (ECM). This activity is controlled by tissue inhibitors of MMP (TIMPs). Aim of this study was the evaluation of ...

Martina Montagnana, Alessandro Volpe, Giuseppe Lippi, Paola Caramaschi, Gian Luca Salvagno, Domenico Biasi, Lisa Maria Bambara, Gian Cesare Guidi (2007) Clin Biochem 40: 12 837-842

Is the activated partial thromboplastin time suitable to screen for von Willebrand factor deficiencies?

2009-02-02T13:54:23Z

The diagnostic approach to von Willebrand factor deficiencies is challenging and requires discretionary use of laboratory resources. Although extensive preoperative testing is not recommended, the activated partial thromboplastin time may be useful, especially in selected categories of patients. To establish the diagnostic sensitivity of this test to identify isolate von Willebrand factor deficien...

Giuseppe Lippi, Massimo Franchini, Giovanni Poli, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi (2007) Blood Coagul Fibrinolysis 18: 4 361-364

Lipoprotein[a] and cancer: anti-neoplastic effect besides its cardiovascular potency.

2009-02-02T13:54:23Z

While the death rate from cancer has substantially decreased over the past decade, the search for effective and tolerable therapies is a great challenge as yet. The evidence that malignant cells cannot grow to a clinically detectable tumor mass and spread in the absence of an adequate vascular support, has opened a new area of research towards the selective inhibition or even destruction of tumor ...

Giuseppe Lippi, Massimo Franchini, Gian Luca Salvagno, Gian Cesare Guidi (2007) Cancer Treat Rev 33: 5 427-436

Lipid and lipoprotein profile in physiological pregnancy.

2009-02-02T13:54:23Z

Physiologic pregnancy is associated with a broad series of metabolic adaptations which may also influence the metabolism of lipids and lipoproteins. Although the modification of serum lipids and lipoproteins has been exhaustively investigated during and after pregnancy, the relative changes recorded vary widely among the different studies. A comprehensive lipid and lipoprotein profile was evaluate...

Giuseppe Lippi, Alessandro Albiero, Martina Montagnana, Gian Luca Salvagno, Silvia Scevarolli, Massimo Franchi, Gian Cesare Guidi (2007) Clin Lab 53: 3-4 173-177

Alanine aminotransferase as an independent predictor of incident nonalcoholic fatty liver disease.

2009-02-02T13:54:23Z

Giovanni Targher, Massimo Franchini, Gian Cesare Guidi, Michele Muggeo, Giuseppe Lippi (2007) Clin Chem 53: 6 1159; author reply 1159-1159; author reply 1161

Relationship between lipoprotein(a) and fasting plasma glucose in the general population.

2009-02-02T13:51:23Z

G Lippi, G Targher, G L Salvagno, M Montagnana, G C Guidi (2007) Eur J Clin Invest 37: 10 826-827

Analytical performances of the D-dimer assay for the Immulite 2000 automated immunoassay analyser.

2009-02-02T13:51:23Z

We evaluated the analytical performances of a new commercial chemiluminescent enzyme immunometric assay for d-dimer measurement on the Immulite 2000 automated analyser. The within- and between-run coefficients of variations for low, intermediate and high d-dimer concentrations ranged from 2.2% to 5.1% and from 2.9% to 6.0% respectively. The assay was proven linear in a range of d-dimer concentrati...

G Lippi, G L Salvagno, L Rossi, M Montagnana, M Franchini, G C Guidi (2007) Int J Lab Hematol 29: 6 415-420

Biochemical correlates of lipoprotein(a) in a general adult population. Possible implications for cardiovascular risk assessment.

2009-02-02T13:51:23Z

Background Evidence has been provided that lipoprotein(a) (Lp(a)) may be an important cardiovascular risk factor. Recognition of potential Lp(a) variability associated with common diseases, such as diabetes, chronic renal dysfunction, impaired liver function and acute/chronic inflammation, is important to optimize the clinical usefulness of this measurement. Methods We performed a retrospective an...

Lippi, Targher, Franchini, Guidi (2007) J Thromb Thrombolysis :

Changes in technical regulations and drivers' safety in top-class motor sports.

2009-02-02T13:51:23Z

Motor racing is a dangerous sport and an inherently risky activity. The organisers of top-class motor sports championships, Formula One and MotoGP, have agreed on a set of regulations to reduce speed and improve safety over the last 10 years. These changes include limitations in weight, fuel and engine capacity. Nevertheless, there is evidence that most of the restrictions that have been introduce...

G Lippi, G L Salvagno, M Franchini, G C Guidi (2007) Br J Sports Med 41: 12 922-925

Has homocysteine shrunk?

2009-02-02T13:51:23Z

Giuseppe Lippi, Giovanni Targher, Massimo Franchini, Gian Cesare Guidi (2007) Clin Chem Lab Med 45: 10 1419-1420

National survey on critical values reporting in a cohort of Italian laboratories.

2009-02-02T13:51:23Z

BACKGROUND: Critical values' reporting is an essential requisite for clinical laboratories. Local policies were investigated within an indicative cohort of Italian laboratories to monitor the situation and establish a performance benchmark. METHODS: A five-point questionnaire was administered to 150 laboratory specialists attending the SIMEL (Italian Society of Laboratory Medicine) National Meetin...

Giuseppe Lippi, Davide Giavarina, Martina Montagnana, Gian Luca Salvagno, Piero Cappelletti, Mario Plebani, Gian Cesare Guidi (2007) Clin Chem Lab Med 45: 10 1411-1413

Influence of haemodialysis on the NT-proBNP plasma concentration.

2009-02-02T13:51:23Z

Giuseppe Lippi, Nicola Tessitore, Gian Luca Salvagno, Martina Montagnana, Antonio Lupo, Gian Cesare Guidi (2007) Clin Chem Lab Med 45: 10 1414-1415

Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults: response to Reis et al.

2009-02-02T13:51:23Z

Giuseppe Lippi, Martina Montagnana, Giovanni Targher, Gian Cesare Guidi (2007) Diabetes Care 30: 12

Prohibition of artificial hypoxic environments in sports: health risks rather than ethics.

2009-02-02T13:51:23Z

There is actual debate on a recent position of the World Anti-Doping Agency (WADA), which has cautiously refrained from banning hypoxic tents and intends to monitor their health risk. Regardless of teleological and deontological concepts, we highlight that the health risks inherent to the widespread use of these artificial performance-enhancing devices would make them as unsafe as other forms of b...

Giuseppe Lippi, Massimo Franchini, Gian Cesare Guidi (2007) Appl Physiol Nutr Metab 32: 6 1206-7; discussion 1208-9

Prevalence and type of preanalytical errors on inpatient samples referred for complete blood count.

2009-02-02T13:51:23Z

Giuseppe Lippi, Antonella Bassi, Giovanni Pietro Solero, Gian Luca Salvagno, Gian Cesare Guidi (2007) Clin Lab 53: 9-12 555-556

Chronic influence of demanding physical exercise on venous blood-gas status.

2009-02-02T13:54:23Z

Although there is comprehensive information on several parameters related to acute changes of the oxygen transport system in athletes, little information is available on chronic adaptations of the respiratory system at rest, as reflected by the out-of-competition venous blood-gas status. Such changes may represent markers of a more efficient oxygen metabolism at rest, associated with a superior ph...

Giuseppe Lippi, Federico Schena, Massimo Franchini, Gian Cesare Guidi (2007) J Sci Med Sport 10: 5 288-290

Coagulation testing in pediatric patients: the young are not just miniature adults.

2009-02-02T13:51:23Z

During the past few decades, great progress has been made toward a better understanding of the development of the hemostatic system. It is now clear that the physiology of hemostasis in pediatric patients differs widely from that in adults, supporting the hypothesis that children might have natural protective mechanisms that justify such variations. However, the correct interpretation of hemostasi...

Giuseppe Lippi, Massimo Franchini, Martina Montagnana, Gian Cesare Guidi (2007) Semin Thromb Hemost 33: 8 816-820

Genomics and proteomics in venous thromboembolism: building a bridge toward a rational personalized medicine framework.

2009-02-02T13:51:23Z

Venous thromboembolism is a major health care problem worldwide and is sustained by a multifactorial pathogenesis where both congenital and acquired causes contribute. It is increasingly being highlighted that a reliable approach based on genomics and proteomics might be effective to construct a rational personalized medicine framework that can be applied in the preclinical, clinical, and therapeu...

Giuseppe Lippi, Massimo Franchini, Martina Montagnana, Gian Cesare Guidi (2007) Semin Thromb Hemost 33: 8 759-770

Improving appropriateness of prostate-specific antigen screening.

2009-02-02T13:51:23Z

Giuseppe Lippi, Martina Montagnana, Gian Cesare Guidi (2007) Arch Intern Med 167: 22 2529-2530

Relationship between lipoprotein(a) and thyroid function status in the general population.

2009-02-02T13:51:23Z

Giuseppe Lippi, Giovanni Targher, Martina Montagnana, Gian Luca Salvagno, Gian Cesare Guidi (2007) Arch Med Res 38: 8 905-6; author reply 907-8

Influence of primary sample mixing on routine coagulation testing.

2009-02-02T13:51:23Z

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi (2007) Blood Coagul Fibrinolysis 18: 7 709-711

Measurement of beta-CTX in lithium heparin plasma.

2009-02-02T13:54:23Z

Giuseppe Lippi, Giorgio Brocco, Francesco Dima, Gian Cesare Guidi (2007) Clin Lab 53: 7-8 453-454

Influence of the sample matrix on the stability of beta-CTX at room temperature for 24 and 48 hours.

2009-02-02T13:54:23Z

The measurement of beta-C-telopeptides of type I collagen (beta-CTX) reflects the rate of bone resorption in a variety of metabolic bone disorders and it is increasingly used to assist diagnosis and follow-up of these pathologies. Since preanalytical biases in the results of this marker can decrease its clinical usefulness, specific stability studies should be developed to prevent that inconsisten...

Giuseppe Lippi, Giorgio Brocco, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi, Heinrich Schmidt-Gayk (2007) Clin Lab 53: 7-8 455-459

Relationship between mean platelet volume and biochemical components of the metabolic syndrome.

2009-02-02T13:54:23Z

Giuseppe Lippi, Gian Luca Salvagno, Giovanni Targher, Gian Cesare Guidi (2007) Clin Drug Investig 27: 10 731-2; author reply 732-3

Association between adducin-1 G460W variant and blood pressure in Swedes is dependent on interaction with body mass index and gender.

2009-02-02T13:54:23Z

BACKGROUND: The W allele of the G460W polymorphism in the adducin-1 gene has been occasionally associated with increased blood pressure (BP). The aim of this study was to test whether the G460W variant is associated with BP levels and BP progression rate and whether G460W associations with BP are affected by sex, body mass index (BMI), or age. METHODS: The G460W polymorphism was genotyped in the p...

Cristiano Fava, Martina Montagnana, Peter Almgren, Lena Rosberg, Gian Cesare Guidi, Göran Berglund, Olle Melander (2007) Am J Hypertens 20: 9 981-989

Genetic analysis to prevent warfarin complications.

2009-02-02T13:54:23Z

Giuseppe Lippi, Gian Luca Salvagno, Gian Cesare Guidi (2007) CMAJ 177: 4

Genetic factors for warfarin dose prediction.

2009-02-02T13:54:23Z

Giuseppe Lippi, Gian Luca Salvagno, Gian Cesare Guidi (2007) Clin Chem 53: 9 1721-1722

Appropriateness of theophylline plasma levels.

2009-02-02T13:54:23Z

Giuseppe Lippi, Gian Luca Salvagno, Giorgio Brocco, Gian Cesare Guidi (2007) Arch Pathol Lab Med 131: 8

Influence of haemodialysis on high-sensitivity C-reactive protein, lipoprotein(a), apolipoproteins A and B.

2009-02-02T13:54:23Z

OBJECTIVES: There is debate on the influence of haemodialysis (HD) on lipoprotein(a). DESIGN AND METHODS: Lp(a), apo A, apo B and high-sensitivity C-reactive protein (hs-CRP) were measured in 46 patients pre- and post-HD. RESULTS: The median Lp(a) concentration significantly decreased post-HD (106 vs. 145 mg/L, p<0.001). No significant variations were observed for apo A, apo B and hs-CRP. Comparab...

Giuseppe Lippi, Nicola Tessitore, Gian Luca Salvagno, Valeria Bedogna, Antonella Bassi, Martina Montagnana, Antonio Lupo, Gian Cesare Guidi (2007) Clin Biochem 40: 16-17 1336-1338

Effect of serum gamma-glutamyltransferase and obesity on the risk of dyslipidemia and poor glycemic control in type 2 diabetic patients: cross-sectional findings from the Verona Diabetes Study.

2009-02-02T13:51:23Z

Giovanni Targher, Giacomo Zoppini, Giuseppe Lippi, Gian Cesare Guidi, Michele Muggeo (2007) Clin Chem 53: 10 1867-9; author reply 1869-70

Significance of plasma B-type natriuretic peptide in hemodialysis patients: blood sample timing and comorbidity burden.

2009-02-02T13:51:23Z

Plasma B-type natriuretic peptide (BNP) concentration was evaluated in end-stage renal disease patients to verify if measurements before or after the session could furnish different information. BNP levels in plasma from 52 hemodialysis (HD) patients were measured both before and after the first session of the week. Echocardiographic studies were also performed and patients were followed over a pe...

Stefano Biasioli, Monica Zamperetti, Donata Borin, Giancesare Guidi, Emanuela De Fanti, Renzo Schiavon (2007) ASAIO J 53: 5 587-591

Relationship between gamma-glutamyltransferase, fasting plasma glucose, and triglycerides in the general population.

2009-02-02T13:51:23Z

Giuseppe Lippi, Giovanni Targher, Gian Cesare Guidi (2007) Clin Chem 53: 10 1866-7; author reply 1869-70

Appropriateness of serum digoxin levels.

2009-02-02T13:54:23Z

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Giorgio Brocco, Gian Cesare Guidi (2007) Eur J Clin Pharmacol 63: 12 1201-1202

Influence of sample matrix and storage on BNP measurement on the Bayer Advia Centaur.

2009-02-02T13:54:23Z

The assessment and management of congestive heart failure relies increasingly on the measurement of B-type natriuretic peptide (BNP). However, the effective contribution of this biochemical test in the clinical decision making is influenced by reliability of the measure, which also depends on several preanalytical issues. Since there is controversy on the influence of the matrix and the storage co...

Giuseppe Lippi, Antonio Fortunato, Gian Luca Salvagno, Martina Montagnana, Giuliano Soffiati, Gian Cesare Guidi (2007) J Clin Lab Anal 21: 5 293-297

Monitoring glycaemic control: is there evidence for appropriate use of routine measurement of glycated haemoglobin?

2009-02-02T13:54:23Z

BACKGROUND: Regardless of the available recommendations to perform glycated haemoglobin testing at a 2- to 3-month frequency, there is increasing evidence of an inappropriate laboratory use of this test in clinical practice. METHODS: Data from our Laboratory Information System were analysed for glycated haemoglobin test orders over a 3-year period using Microsoft Excel to calculate the order inter...

Gian Luca Salvagno, Giuseppe Lippi, Giovanni Targher, Martina Montagnana, Gian Cesare Guidi (2007) Clin Chem Lab Med 45: 8 1065-1067

Readers' response and author's reply to "Laboratory results that should be ignored".

2009-02-02T13:54:23Z

Giuseppe Lippi, Gian Cesare Guidi (2006) MedGenMed 8: 4

Potential value for new diagnostic markers in the early recognition of acute coronary syndromes.

2009-02-02T13:54:23Z

The diagnostic approach to acute coronary syndromes (ACS) remains one of the most difficult and controversial challenges facing emergency physicians. In recent years, cardiac troponins have emerged as the biochemical "gold standard" for diagnosis of patients with acute chest pain, enhancing our ability to recognize ACS. Early diagnosis and treatment of myocardial ischemia improve patient outcomes,...

Giuseppe Lippi, Martina Montagnana, Gian Luca Salvagno, Gian Cesare Guidi (2006) CJEM 8: 1 27-31

Plasma D-dimer variation following elective orthopedic surgery.

2009-02-02T13:57:51Z

Giuseppe Lippi, Martina Montagnana, Dario Regis, Gino Viola, Gian Cesare Guidi (2006) Blood Coagul Fibrinolysis 17: 1 87-88

Preanalytical variability: the dark side of the moon in laboratory testing.

2009-02-02T13:57:51Z

Remarkable advances in instrument technology, automation and computer science have greatly simplified many aspects of previously tedious tasks in laboratory diagnostics, creating a greater volume of routine work, and significantly improving the quality of results of laboratory testing. Following the development and successful implementation of high-quality analytical standards, analytical errors a...

Giuseppe Lippi, Gian Cesare Guidi, Camilla Mattiuzzi, Mario Plebani (2006) Clin Chem Lab Med 44: 4 358-365

Influence of warfarin therapy on activated factor VII clotting activity.

2009-02-02T13:57:51Z

Oral anticoagulant therapy has been widely employed to prevent and treat a variety of thrombotic disorders, although a new generation of antithrombotic drugs, which offer inhibition of clot-bound as well as fluid-phase thrombin, has been developed and tested in several clinical trials. Although most anticoagulant responses to hydroxycoumarin compounds are well established, there are controversial ...

Giuseppe Lippi, Martina Montagnana, Gian Luca Salvagno, Giovanni Poli, Massimo Franchini, Gian Cesare Guidi (2006) Blood Coagul Fibrinolysis 17: 3 221-224

Evaluation of platelet turnover by flow cytometry.

2009-02-02T13:57:51Z

The number of circulating newly produced platelets depends on the thrombopoietic capacity of bone marrow as well as platelet removal from the bloodstream. Flow cytometric analysis with thiazole orange (TO), a fluorescent dye that crosses platelet membranes and binds intracellular RNA, has been used to measure circulating reticulated platelets (RPs) with high RNA content as an index of platelet tur...

G L Salvagno, M Montagnana, M Degan, P L Marradi, M M Ricetti, P Riolfi, G Poli, P Minuz, C L Santonastaso, G C Guidi (2006) Platelets 17: 3 170-177

The influence of the tourniquet time on hematological testing for antidoping purposes.

2009-02-02T13:57:51Z

Hematological manipulation to optimize aerobic performances is a serious problem in elite and professional sports and the approach to identify blood doping is as yet challenging. In most cases, the current strategy contemplates a first stage of analysis, based on the application of arbitrary threshold for hemoglobin or hematocrit, followed by second-generation blood tests, or the adoption of an in...

G Lippi, G L Salvagno, G P Solero, G C Guidi (2006) Int J Sports Med 27: 5 359-362

Preanalytic error tracking in a laboratory medicine department: results of a 1-year experience.

2009-02-02T13:57:51Z

Giuseppe Lippi, Antonella Bassi, Giorgio Brocco, Martina Montagnana, Gian Luca Salvagno, Gian Cesare Guidi (2006) Clin Chem 52: 7 1442-1443

Biochemistry, physiology, and complications of blood doping: facts and speculation.

2009-02-02T13:57:51Z

Competition is a natural part of human nature. Techniques and substances employed to enhance athletic performance and to achieve unfair success in sport have a long history, and there has been little knowledge or acceptance of potential harmful effects. Among doping practices, blood doping has become an integral part of endurance sport disciplines over the past decade. The definition of blood dopi...

Giuseppe Lippi, Massimo Franchini, Gian Luca Salvagno, Gian Cesare Guidi (2006) Crit Rev Clin Lab Sci 43: 4 349-391

Albumin cobalt binding and ischemia modified albumin generation: an endogenous response to ischemia?

2009-02-02T13:57:51Z

Giuseppe Lippi, Martina Montagnana, Gian Cesare Guidi (2006) Int J Cardiol 108: 3 410-411

Comparison of the lipid profile and lipoprotein(a) between sedentary and highly trained subjects.

2009-02-02T13:57:51Z

BACKGROUND: There is consolidated evidence that physical activity exerts beneficial effects on several chronic conditions and longevity, on the basis of its proposed biological effects, especially on lipid profiles. However, debate continues regarding the intensity of activity required for good health, as vigorous physical activity might overwhelm advantageous changes. In addition, little is known...

Giuseppe Lippi, Federico Schena, Gian Luca Salvagno, Martina Montagnana, Filippo Ballestrieri, Gian Cesare Guidi (2006) Clin Chem Lab Med 44: 3 322-326

Plasma D-dimer concentration in patients with systemic sclerosis.

2009-02-02T13:57:51Z

BACKGROUND: Systemic sclerosis (SSc) is an autoimmune disorder of the connective tissue characterized by widespread vascular lesions and fibrosis. Little is known so far on the activation of the hemostatic and fibrinolytic systems in SSc, and most preliminary evidences are discordant. METHODS: To verify whether SSc patients might display a prothrombotic condition, plasma D-dimer was assessed in 28...

Giuseppe Lippi, Alessandro Volpe, Paola Caramaschi, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi (2006) Thromb J 4:

Influence of physical exercise and relationship with biochemical variables of NT-pro-brain natriuretic peptide and ischemia modified albumin.

2009-02-02T13:57:51Z

BACKGROUND: The diagnostic approach and the clinical management of patients presenting with suspected acute coronary syndrome or cardiac dysfunction are as yet challenging. Although ischemia modified albumin (IMA) and natriuretic peptides were recently proposed for detection of myocardial ischemia and cardiac dysfunction, little information is available on preanalytical and metabolic sources of va...

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Federico Schena, Filippo Ballestrieri, Gian Cesare Guidi (2006) Clin Chim Acta 367: 1-2 175-180

Lipoprotein[a] and the lipid profile in patients with systemic sclerosis.

2009-02-02T13:57:51Z

BACKGROUND: Systemic sclerosis (SSc) is an autoimmune disorder of the connective tissue characterized by widespread vascular lesions and fibrosis, associated with endothelial dysfunction, that might finally promote occlusive vascular complications. Little is known so far on the lipid profile of these patients. METHODS: To investigate the potential contribution of lipid abnormalities in genesis and...

Giuseppe Lippi, Paola Caramaschi, Martina Montagnana, Gian Luca Salvagno, Alessandro Volpe, Giancesare Guidi (2006) Clin Chim Acta 364: 1-2 345-348

Ischemia-modified albumin and NT-prohormone-brain natriuretic peptide in peripheral arterial disease.

2009-02-02T13:57:51Z

Cardiovascular disease is the leading cause of mortality and morbidity in Western countries. Despite its remarkable medical and social consequences, the prevalence of peripheral arterial disease (PAD) is often underestimated among atherosclerotic disorders. So far, little is known about the behavior of traditional and emerging markers of ischemic heart disease that should allow the reliable identi...

Martina Montagnana, Giuseppe Lippi, Cristiano Fava, Pietro Minuz, Clara Lechi Santonastaso, Enrico Arosio, Gian Cesare Guidi (2006) Clin Chem Lab Med 44: 2 207-212

Laboratory quality improvement by implementation of phlebotomy guidelines.

2009-02-02T13:57:51Z

Giuseppe Lippi, Camilla Mattiuzzi, Gian Cesare Guidi (2006) MLO Med Lab Obs 38: 1 6-7; author reply 7

Influence of hemolysis on routine clinical chemistry testing.

2009-02-02T13:57:51Z

BACKGROUND: Preanalytical factors are the main source of variation in clinical chemistry testing and among the major determinants of preanalytical variability, sample hemolysis can exert a strong influence on result reliability. Hemolytic samples are a rather common and unfavorable occurrence in laboratory practice, as they are often considered unsuitable for routine testing due to biological and ...

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Giorgio Brocco, Gian Cesare Guidi (2006) Clin Chem Lab Med 44: 3 311-316

Influence of centrifuge temperature on routine coagulation testing.

2009-02-02T13:57:51Z

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Giovanni Poli, Gian Cesare Guidi (2006) Clin Chem 52: 3 537-538

Phlebotomy issues and quality improvement in results of laboratory testing.

2009-02-02T13:57:51Z

Laboratory testing is an integral part of the decision-making process, and results of laboratory testing often strongly influence medical diagnoses and therapies. There is a long history of quality requirements in laboratory medicine, which have mainly concerned the analytic phase of this process. Owing to the substantial advances in technology, laboratory automation and analytic quality, there is...

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Massimo Franchini, Gian Cesare Guidi (2006) Clin Lab 52: 5-6 217-230

Interference of blood cell lysis on routine coagulation testing.

2009-02-02T13:57:51Z

CONTEXT: Preanalytical factors influencing the reliability of laboratory testing are commonplace. It is traditionally accepted that hemolytic samples are unsuitable for coagulation assays because of the release of hemoglobin, intracellular components, and thromboplastic substances from damaged blood cells. OBJECTIVE: To evaluate the influence of blood cell lysis on routine coagulation testing. DES...

Giuseppe Lippi, Martina Montagnana, Gian Luca Salvagno, Gian Cesare Guidi (2006) Arch Pathol Lab Med 130: 2 181-184

Evaluation of four portable self-monitoring blood glucose meters.

2009-02-02T13:57:51Z

Self-monitoring of blood glucose (SMBG) is a cornerstone of diabetes care. However, the effectiveness of any glucose-monitoring programme depends on the ability to integrate SMBG into a program of self-care and therapeutic decision-making. Because the accuracy of SMBG is instrument dependent, we analysed 45 heparinized whole blood specimens using four marketed portable glucose meters to evaluate w...

Giuseppe Lippi, Gian Luca Salvagno, Gian Cesare Guidi, Mauro Negri, Paolo Rizzotti (2006) Ann Clin Biochem 43: Pt 5 408-413

Health benefits of physical activity.

2009-02-02T13:57:51Z

Giuseppe Lippi, Federico Schena, Gian Cesare Guidi (2006) CMAJ 175: 7

Venous stasis and routine hematologic testing.

2009-02-02T13:57:51Z

Prolonged venous stasis, as generated by a long tourniquet placement, produces spurious variations in several measurable analytes. To verify to what extent venous stasis influences routine hematologic testing, we assessed routine hematologic parameters, including hemoglobin, hematocrit, red blood cell count (RBC), main cell hemoglobin (MHC), main cell volume (MCV), platelet count (PLT), main plate...

G Lippi, G L Salvagno, M Montagnana, M Franchini, G C Guidi (2006) Clin Lab Haematol 28: 5 332-337

Preanalytic indicators of laboratory performances and quality improvement of laboratory testing.

2009-02-02T13:54:23Z

Laboratory diagnosis is traditionally a three-part process that develops within the preanalytic, analytic and post-analytic phases. There is consolidated evidence that lack of standardization and monitoring of preanalytic variables, including procedures for patient identification, sample collection, handling and processing has an adverse influence on the reliability of test results, consuming valu...

Giuseppe Lippi, Gian Cesare Guidi (2006) Clin Lab 52: 9-10 457-462

Evaluation of cardiac involvement following major orthopedic surgery.

2009-02-02T13:54:23Z

BACKGROUND: Cardiovascular morbidity is frequent after non-cardiac surgery and the early recognition of cardiac involvement is an essential tool for clinical risk stratification and management. The aim of this study was to investigate the behavior of traditional and emerging cardiac markers, including NT-prohormone-brain natriuretic peptide (NT-proBNP) and ischemia-modified albumin (IMA), in the p...

Martina Montagnana, Giuseppe Lippi, Dario Regis, Cristiano Fava, Gino Viola, Pietro Bartolozzi, Gian Cesare Guidi (2006) Clin Chem Lab Med 44: 11 1340-1346

Managing transferability of laboratory data.

2009-02-02T13:57:51Z

Considerable attention has been focused on definition and enhancement of the analytical quality in laboratory testing over the past decades. Advances in laboratory technology and computer informatics have allowed a major sense of confidence with the analytical phase and more efforts should now be focused on extra-analytical areas of improvement, that should further strengthen the link between cost...

Gian Cesare Guidi, Giuseppe Lippi, Giovanni Pietro Solero, Giovanni Poli, Mario Plebani (2006) Clin Chim Acta 374: 1-2 57-62

Thyroid status in patients with systemic sclerosis.

2009-02-02T13:54:23Z

Giuseppe Lippi, Paola Caramaschi, Martina Montagnana, Gian Luca Salvagno, Alessandro Volpe, Gian Cesare Guidi (2006) J Clin Rheumatol 12: 6 322-324

Influence of the needle bore size on platelet count and routine coagulation testing.

2009-02-02T13:57:51Z

The phlebotomy technique, particularly the use of small-bore needles, may influence the reliability of coagulation testing and platelet count. Routine coagulation tests were assayed in blood specimens collected from 22 consecutive patients in three separate, sequential phlebotomies, using butterfly devices with different needle sizes. Test results of samples collected with 23 and 25 G needles were...

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Giovanni Poli, Gian Cesare Guidi (2006) Blood Coagul Fibrinolysis 17: 7 557-561

Low levels of activated factor VII in systemic sclerosis.

2009-02-02T13:57:51Z

INTRODUCTION: Recent investigations show that activated factor VII, the primary enzyme in the extrinsic pathway of blood coagulation, exerts additional extra-coagulant functions, such as apoptosis and angiogenesis. On the basis of these recent acquisitions, the present study was aimed to evaluate activated factor VII in patients with systemic sclerosis and to establish a potential association with...

Alessandro Volpe, Gian Luca Salvagno, Giuseppe Lippi, Paola Caramaschi, Martina Montagnana, Sabrina Canestrini, Antonio Carletto, Lisa Maria Bambara, Domenico Biasi, Gian Cesare Guidi (2006) J Thromb Thrombolysis 22: 2 133-138

Quality and reliability of routine coagulation testing: can we trust that sample?

2009-02-02T13:57:51Z

Poor standardization of preanalytic variables exerts a strong influence on the reliability of coagulation testing, consuming valuable health care resources and compromising patient outcome. Most uncertainties emerge from patient misidentification and the procedures for specimen collection and handling. Location of unsuitable venous access or problematic phlebotomies may produce spurious activation...

Giuseppe Lippi, Massimo Franchini, Martina Montagnana, Gian Luca Salvagno, Giovanni Poli, Gian Cesare Guidi (2006) Blood Coagul Fibrinolysis 17: 7 513-519

Non-steroidal anti-inflammatory drugs in athletes.

2009-02-02T13:57:51Z

G Lippi, M Franchini, G C Guidi, W F Kean (2006) Br J Sports Med 40: 8 661-2; discussion 662-3

Blood doping by cobalt. Should we measure cobalt in athletes?

2009-02-02T13:57:51Z

BACKGROUND: Blood doping is commonplace in competitive athletes who seek to enhance their aerobic performances through illicit techniques. PRESENTATION OF THE HYPOTHESIS: Cobalt, a naturally-occurring element with properties similar to those of iron and nickel, induces a marked and stable polycythemic response through a more efficient transcription of the erythropoietin gene. TESTING THE HYPOTHESI...

Giuseppe Lippi, Massimo Franchini, Gian Cesare Guidi (2006) J Occup Med Toxicol 1:

Comparison of platelet function between sedentary individuals and competitive athletes at rest.

2009-02-02T13:57:51Z

BACKGROUND: There are controversial evidences on the effect of different types and workloads of physical exercise on primary hemostasis. In particular, little is known on the chronic influence of a strenuous and regular aerobic training regimen on platelet function. METHODS: The aim of this investigation was to compare platelet function between sedentary controls and trained athletes at rest and t...

Giuseppe Lippi, Martina Montagnana, Gian Luca Salvagno, Massimo Franchini, Gian Cesare Guidi (2006) Thromb J 4:

Laboratory medicine in the 2000s: programmed death or rebirth?

2009-02-02T13:57:51Z

Changes have occurred in the organization, complexity and role of medical laboratories in healthcare, requiring a great increase in global productivity and diagnostic efficiency by enrolled professionals to withstand new challenges. Such a radical evolution, which should be very attractive for new generations of professionals, is counterbalanced by an increasing shortage of laboratory vocations wo...

Gian Cesare Guidi, Giuseppe Lippi (2006) Clin Chem Lab Med 44: 8 913-917

The skilled phlebotomist.

2009-02-02T13:57:51Z

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi (2006) Arch Pathol Lab Med 130: 9 1260-1261

Reliability of the thrombin-generation assay in frozen-thawed platelet-rich plasma.

2009-02-02T13:57:51Z

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi (2006) Clin Chem 52: 9 1827-1828

Short-term venous stasis influences routine coagulation testing.

2009-02-02T14:00:13Z

Preanalytical variability is a common source of errors in coagulation testing, as clotting assays are particularly susceptible to poor standardization of the whole analytical process. To investigate the effect of a short-term venous stasis on routine coagulation testing, we measured activated partial thromboplastin time, prothrombin time, fibrinogen and D-dimer in plasma specimens collected either...

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi (2005) Blood Coagul Fibrinolysis 16: 6 453-458

Effective measures to improve driver safety.

2009-02-02T13:57:51Z

G Lippi, G C Guidi (2005) Br J Sports Med 39: 9

Haematological testing and antidoping policies - Re: Robinson N, Schattenberg L, Zorzoli M, Mangin P, Saugy M. Haematological analysis conducted at the departure of the Tour de France 2001. Int J Sports Med 2005; 26: 200-207.

2009-02-02T14:00:13Z

G Lippi, M Franchini, G C Guidi (2005) Int J Sports Med 26: 6 508-9; author reply 510-1

Total and free PSA serum concentrations are not influenced by extensive physical exercise and bicycle riding.

2009-02-02T14:00:13Z

Vigorous and prolonged physical exercise and mechanical involvement of the perineal region might influence prostatic function and measurement of both total (PSA) and free prostate specific antigen (fPSA), decreasing the diagnostic efficiency of the laboratory screening for either benign or neoplastic prostate disorders in athletes. To investigate the effects of regular and strenuous physical exerc...

G Lippi, A Corgnati, G Salvagno, F Schena, M Franchini, G Guidi (2005) Int J Sports Med 26: 1 79-81

Influence of two different buffered sodium citrate concentrations on coagulation testing.

2009-02-02T14:00:13Z

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Gian Cesare Guidi (2005) Blood Coagul Fibrinolysis 16: 5 381-383

Serum ferritin as a marker of potential biochemical iron overload in athletes.

2009-02-02T13:57:51Z

OBJECTIVES: Beyond hematological manipulation, iron supplementation therapy is commonplace in athletes to counterbalance physiological or pathologic anemia and to prevent physiologic dysfunction. However, misuse of iron therapy, occasionally resulting in iron overload, is not free from metabolic risks. DESIGN: We planned to measure baseline serum ferritin concentration in sedentary individual and ...

Giuseppe Lippi, Federico Schena, Massimo Franchini, Gian Luca Salvagno, Gian Cesare Guidi (2005) Clin J Sport Med 15: 5 356-358

Preanalytical variability in laboratory testing: influence of the blood drawing technique.

2009-02-02T14:00:13Z

The predominant technique used to draw blood for laboratory testing is a conventional straight needle attached to an evacuated tube system. However, alternative tools might be advantageous in exceptional circumstances. The use of butterfly devices has been traditionally discouraged for reasons of costs and due to the high risk of obtaining unsuitable samples, but there is no convincing evidence to...

Giuseppe Lippi, Gian Luca Salvagno, Giorgio Brocco, Gian Cesare Guidi (2005) Clin Chem Lab Med 43: 3 319-325

New perspectives in the diagnostic approach to acute coronary syndrome

2009-02-02T14:00:13Z

Cardiovascular disorders and acute coronary syndrome represent the leading pathologies in western countries. Over 30 years from the first diagnostic criteria issued by the World Health Organization, the diagnostic approach to patients with non-traumatic chest pain is as yet challenging. Investigators have attempted various diagnostic strategies, such as clinical decision algorithms, cardiac biomar...

Martina Montagnana, Giuseppe Lippi, Gian Cesare Guidi (2005) Recenti Prog Med 96: 4 171-177

No influence of a butterfly device on routine coagulation assays and D-dimer measurement.

2009-02-02T14:00:13Z

G Lippi, G L Salvagno, G C Guidi (2005) J Thromb Haemost 3: 2 389-391

Thromboprophylaxis in stroke patients.

2009-02-02T13:57:51Z

Giuseppe Lippi, Gian Cesare Guidi (2005) Stroke 36: 10 2067-8; author reply 2068

Stability of blood cell counts, hematologic parameters and reticulocytes indexes on the Advia A120 hematologic analyzer.

2009-02-02T13:57:51Z

Delayed sample analysis is not a rare circumstance in clinical and laboratory practice, especially when blood samples are shipped to distant centralized laboratories, when the analysis can not be readily performed, or when retesting is appropriate. In this study we sought to evaluate the stability of conventional and new hematologic parameters in blood specimens stored for as long as 24 hours at 4...

Giuseppe Lippi, Gian Luca Salvagno, Gian Pietro Solero, Massimo Franchini, Gian Cesare Guidi (2005) J Lab Clin Med 146: 6 333-340

Preoperative laboratory testing

2009-02-02T13:57:51Z

The preoperative laboratory screening is commonplace in clinical practice and is traditionally defined as the practice of prescribing laboratory testing before surgery on patients undergoing a given procedure. The wide heterogeneity of the solutions prospected over the past decades emphasizes the objective difficulty at issuing definitive guidelines and recommendations. Despite its widespread use,...

G Lippi, M Montagnana, C Mattiuzzi, M Franchini, V Alberti, G C Guidi (2005) Minerva Med 96: 6 397-407

Chronic influence of vigorous aerobic training on hemostasis.

2009-02-02T13:57:51Z

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagana, Gian Cesare Guidi (2005) Blood Coagul Fibrinolysis 16: 7 533-534

Other advantages to aerobic exercise.

2009-02-02T13:57:51Z

Giuseppe Lippi, Gian Luca Salvagno, Gian Cesare Guidi (2005) CMAJ 173: 9

Predicting cardiac outcomes.

2009-02-02T13:57:51Z

Giuseppe Lippi, Martina Montagnana, Gian Cesare Guidi (2005) CMAJ 173: 10 1206-7; author reply 1207

Influence of short-term venous stasis on clinical chemistry testing.

2009-02-02T13:57:51Z

Control and standardization of preanalytical variability is a critical factor for achieving accuracy and precision in laboratory testing. Although venous stasis from tourniquet placement during venepuncture should be minimized, as it has been claimed to account for spurious and significant variations for several analytes in plasma, there is controversy surrounding its real impact on laboratory tes...

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Giorgio Brocco, Gian Cesare Guidi (2005) Clin Chem Lab Med 43: 8 869-875

High-workload endurance training may increase serum ischemia-modified albumin concentrations.

2009-02-02T13:57:51Z

The measurement of cardiac troponins has emerged as the biochemical "gold standard" for the diagnosis and management of patients with acute chest pain. However, earlier markers should support investigation strategies, as several patients with acute coronary syndrome might present with non-diagnostic concentrations. Ischemia-modified albumin (IMA), measured by the albumin cobalt binding (ACB) assay...

Giuseppe Lippi, Giorgio Brocco, Gian Luca Salvagno, Martina Montagnana, Francesco Dima, Gian Cesare Guidi (2005) Clin Chem Lab Med 43: 7 741-744

Cobalt chloride administration in athletes: a new perspective in blood doping?

2009-02-02T13:57:51Z

Blood doping is an illegal and unfair way of enhancing athletic performance by increasing the oxygen carrying capacity of the blood. Currently used methods usually involve stimulation of erythropoiesis. Gene therapy targeting the hypoxia inducible factor pathway may be an attractive alternative to traditional blood doping techniques. Hypoxia activates a large number of genes with essential roles i...

G Lippi, M Franchini, G C Guidi (2005) Br J Sports Med 39: 11 872-873

Second generation blood tests to detect erythropoietin abuse by athletes: effective but not preventive?

2009-02-02T14:00:13Z

Giuseppe Lippi, Massimo Franchini, Giancesare Guidi (2004) Haematologica 89: 4

Athletes genotyping: ethical and legal issues.

2009-02-02T14:00:13Z

G Lippi, G P Solero, G Guidi (2004) Int J Sports Med 25: 2 159; author reply 160-159; author reply 161

Comparison of serum creatinine, uric acid, albumin and glucose in male professional endurance athletes compared with healthy controls.

2009-02-02T14:00:13Z

Owing to considerable physical, endocrinological and metabolic adaptations, the analysis of biochemical data in elite and top-class athletes requires caution. With the aim to identify metabolic and biochemical adaptations to particular lifestyle conditions, such as regular and strenuous physical exercise, we measured the concentration of serum albumin, creatinine, uric acid and glucose in 80 male ...

Giuseppe Lippi, Giorgio Brocco, Massimo Franchini, Federico Schena, Giancesare Guidi (2004) Clin Chem Lab Med 42: 6 644-647

Metabolic risks of completing Giro, Tour, and Vuelta in the same season.

2009-02-02T14:00:13Z

G Lippi, G Guidi (2004) Br J Sports Med 38: 1

Effect of specimen collection on routine coagulation assays and D-dimer measurement.

2009-02-02T14:00:13Z

Giuseppe Lippi, Gian Cesare Guidi (2004) Clin Chem 50: 11 2150-2152

Gene manipulation and improvement of athletic performances: new strategies in blood doping.

2009-02-02T14:00:13Z

G Lippi, G C Guidi (2004) Br J Sports Med 38: 5

Prevention of doping in sports: epidemiological issues and ethical implications

2009-02-02T14:00:13Z

Owing to a widespread diffusion, the consumption of banned and potentially harmful substances in sports has become a problem for the public health. Current estimations of the prevalence of doping in sports are rather uncertain, as most investigative tools do not reflect an absolute statistical power. However, the emerging scenario reflects a concerning underestimation by Structures and Institution...

Giuseppe Lippi, Camilla Mattiuzzi, Giancesare Guidi (2004) Epidemiol Prev 28: 3 178-183

New scenarios in antidoping research.

2009-02-02T14:00:13Z

Giuseppe Lippi, Giancesare Guidi (2003) Clin Chem 49: 12 2106-2107

Lipoprotein(a): an emerging cardiovascular risk factor.

2009-02-02T14:00:13Z

Lipoprotein(a) is a cholesterol-enriched lipoprotein, consisting of a covalent linkage joining the unique and highly polymorphic apolipoprotein(a) to apolipoprotein B100, the main protein moiety of low-density lipoproteins. Although the concentration of lipoprotein(a) in humans is mostly genetically determined, acquired disorders might influence synthesis and catabolism of the particle. Raised con...

Giuseppe Lippi, Giancesare Guidi (2003) Crit Rev Clin Lab Sci 40: 1 1-42

Lipoprotein(a): atherogenesis linked to thrombosis and inflammation at last?

2009-02-02T14:00:13Z

Giuseppe Lippi, Giancesare Guidi (2003) Am J Kidney Dis 42: 6

Risk factors for cardiovascular disease.

2009-02-02T14:00:13Z

Giuseppe Lippi, Giancesare Guidi (2002) CMAJ 166: 6

Haematocrit measurement and antidoping policies.

2009-02-02T14:00:13Z

G Lippi, M Franchini, G Guidi (2002) Clin Lab Haematol 24: 1 65-66

Prothrombotic effects and clinical implications of third-generation oral contraceptives use.

2009-02-02T14:00:13Z

Although the use of oral contraceptives has been frequently associated with an increased risk of thromboembolic events, definitive prothrombotic mechanisms have not so far been fully elucidated. The aim of our investigation was the evaluation of the activities of antithrombin, protein C, protein S and the resistance to activated protein C in 137 healthy users of third-generation oral contraceptive...

G Lippi, F Manzato, G Brocco, M Franchini, G Guidi (2002) Blood Coagul Fibrinolysis 13: 1 69-72

HDL3-related decreased serum paraoxonase (PON) activity in uremic patients: comparison with the PON1 allele polymorphism.

2009-02-02T14:00:13Z

BACKGROUND: Patients with chronic renal failure on maintenance haemodialysis (HD) are at high risk of atherothrombotic events; an enhanced oxidant stress might have a major role. The decrease of human paraoxonase (PON1), an anti-oxidant high-density lipoprotein (HDL)-linked enzyme, is a possible mechanism for developing cardiovascular disease. To ascertain the causes of low PON1 in such patients, ...

Renzo Schiavon, Paolo Battaglia, Emanuela De Fanti, Antonio Fasolin, Stefano Biasioli, Lino Targa, Giancesare Guidi (2002) Clin Chim Acta 324: 1-2 39-44

Relationship between hematocrit, primary hemostasis, and cardiovascular disease in athletes.

2009-02-02T14:00:13Z

Giuseppe Lippi, Franco Manzato, Massimo Franchini, Giancesare Guidi (2002) Am Heart J 144: 5

Relation between regular aerobic physical exercise and inflammatory markers.

2009-02-02T14:00:13Z

Giuseppe Lippi, Antonella Bassi, Giancesare Guidi, Mario Zatti (2002) Am J Cardiol 90: 7

...relationship between dislipidemia and thrombosis yet unproven.

2009-02-02T14:00:13Z

G Lippi, G Guidi (2001) Blood Coagul Fibrinolysis 12: 1 81-83

Establishment of reference values for the PFA-100 platelet function analyzer in pediatrics.

2009-02-02T14:00:13Z

G Lippi, F Manzato, M Franchini, G Brocco, G Florenziani, G Guidi (2001) Clin Exp Med 1: 1 69-70

Cardiovascular risk factors in patients with chronic renal failure maintained on hemodialysis or continuous ambulatory peritoneal dialysis.

2009-02-02T14:00:13Z

G Lippi, N Tessitore, L Gammaro, C Rugiu, G Maschio, G Guidi (2001) Thromb Res 101: 6 517-519

Variation of plasma D-dimer following surgery: implications for prediction of postoperative venous thromboembolism.

2009-02-02T14:00:13Z

The prognosis of venous thromboembolism is considerably influenced by an accurate and fast diagnosis. Although the role of D-dimer testing in the diagnosis of suspected venous thromboembolism is well established for outpatients, there is controversial evidence on the clinical usefulness of its measurement in surgical patients. In order to recognize patterns of variation of D-dimer following surger...

G Lippi, G F Veraldi, M Fraccaroli, F Manzato, C Cordiano, G Guidi (2001) Clin Exp Med 1: 3 161-164

Biochemical risk factors for cardiovascular disease in an aged male population: emerging vascular pathogens.

2009-02-02T14:00:13Z

The progressive increase of deaths and morbidity from cardiovascular disease (CVD) in most developed societies has led to the formulation of preventive strategies and application of several diagnostic guidelines. However, there is emerging evidence that most panels and algorithms are inadequate and require urgent revision and updating. Therefore, the aim of this study was the evaluation of a wide ...

G Lippi, E Arosio, M Prior, G Guidi (2001) Angiology 52: 10 681-687

Lipoprotein(a): from ancestral benefit to modern pathogen?

2009-02-02T14:02:39Z

We review current concepts regarding the genetic, structural and metabolic features of lipoprotein(a), a major inherited cardiovascular pathogen. Although lipoprotein(a) is almost completely confined to a subset of primates, the hedgehog produces a lipoprotein(a)-like complex, which appears to have evolved independently from that of humans. The physiological role of lipoprotein(a) in humans is sti...

G Lippi, G Guidi (2000) QJM 93: 2 75-84

Chronic intravenous aminobisphosphonate therapy increases high-density lipoprotein cholesterol and decreases low-density lipoprotein cholesterol.

2009-02-02T14:00:13Z

Nowadays, bisphosphonates are considered the drugs of choice for the treatment of several bone disorders. Their exact mechanism of action is not clear but recently it has been reported that the aminobisphosphonates inhibit cholesterol biosynthesis and that this might be relevant for their actions on bone osteoclasts. The study includes 87 postmenopausal women with moderate to severe osteoporosis. ...

S Adami, V Braga, G Guidi, D Gatti, D Gerardi, E Fracassi (2000) J Bone Miner Res 15: 3 599-604

Laboratory screening for erythropoietin abuse in sport: an emerging challenge.

2009-02-02T14:00:13Z

The growing diffusion of banned practice to improve the athletic performances is forcing clinical laboratories to identify and standardize reliable assays to detect potential unfairness. Among the doping practices, the use of recombinant human erythropoietin is becoming fairly popular, due to simplicity and safeties of administration and troublesome detection. The heterogeneous response rate, the ...

G Lippi, G Guidi (2000) Clin Chem Lab Med 38: 1 13-19

Lipoprotein(a) concentration is not associated with venous thromboembolism in a case control study.

2009-02-02T14:02:39Z

BACKGROUND AND OBJECTIVE: Lipoprotein(a) is an LDL-like particle displaying strong athero-thrombotic properties. Although Lp(a) plays a pivotal role in the genesis and progression of thrombosis in the arterial district, its role in promoting thrombosis in the venous district is still unclear. DESIGN AND METHODS: To give further insight into the thrombotic potential of Lp(a), 100 potentially eligib...

G Lippi, A Bassi, G Brocco, F Manzato, M Marini, G Guidi (1999) Haematologica 84: 8 726-729

Biochemical risk factors and patient's outcome: the case of lipoprotein(a).

2009-02-02T14:02:39Z

Lipoprotein(a) (Lp(a)) is a genetic variant of low density lipoproteins and consists of the covalent association of the unique and enigmatic apolipoprotein(a) to apoliprotein B100. Despite the high degree of homology with low density lipoproteins, Lp(a) displays distinctive physico-chemical properties, function and metabolism. The present article reviews the main biological and clinical evidences ...

G Lippi, G Guidi (1999) Clin Chim Acta 280: 1-2 59-71

Effects of sodium selenite on in vitro interactions between platelets and endothelial cells.

2009-02-02T14:02:39Z

Selenium is an essential component of glutathione peroxidase enzymes, which protect cells against peroxidation and control concentrations of intracellular proxides. Since selenium deficiency is associated with an increased incidence of arterial thrombosis, we studied the effect of selenium on in vitro interactions between platelets and endothelial cells. Platelets from normal volunteers on a diet ...

M M Ricetti, G C Guidi, C Tecchio, G Bellisola, A Rigo, G Perona (1999) Int J Clin Lab Res 29: 2 80-84

Relationship between venous thromboembolism and lipid or lipoprotein disorders.

2009-02-02T14:02:39Z

G Lippi, G Brocco, F Manzato, G Guidi (1999) Thromb Res 95: 6 353-354

Doping and sports

2009-02-02T14:02:39Z

Doping is widely known as the use of banned substances and practices by athletes in an attempt to improve sporting performances. The term doping likely derives from "dope", an ancient expression referred to a primitive alcoholic drink that was used as a stimulant in South African ceremonial dances; gradually, the term was extended and finally adopted his current significance. There are at least tw...

G Lippi, G Guidi (1999) Minerva Med 90: 9 345-357

Lipoprotein (a) and ischaemic cerebrovascular disease.

2009-02-02T14:02:39Z

G Lippi, G Guidi (1998) Ann Clin Biochem 35 ( Pt 2): 327-329

Positive immunostaining with MLuC1 of bone marrow aspirate predicts poor outcome in patients with small-cell lung cancer.

2009-02-02T14:02:39Z

BACKGROUND: Immunocytochemistry has been proven able to identify tumor cells in bone marrow aspirate (BMA) of patients with SCLC. However, few data exist about the clinical significance of the procedure. PATIENTS AND METHODS: 108 BMA taken from 60 patients were incubated with the MoAb MLuC1 (cluster 6) and stained by the APAAP (alkaline phosphatase-antialkaline phosphatase) method. The serum level...

F Pasini, G Pelosi, G Verlato, G Guidi, F Pavanel, D Tummarello, A Masotti, G L Cetto (1998) Ann Oncol 9: 2 181-185

Modification of serum apolipoprotein A-I, apolipoprotein B and lipoprotein(a) levels after bisphosphonates-induced acute phase response.

2009-02-02T14:02:39Z

Lipoprotein(a) (Lp(a)) is a low density lipoprotein-like particle displaying strong atherothrombotic properties. Although the concentration of Lp(a) in plasma is under strong genetic regulation, there are emerging evidences that several other factors, such as hormonal disorders, acute phase, liver and renal failure may affect its metabolism. The aim of the present study was to investigate whether ...

G Lippi, V Braga, S Adami, G Guidi (1998) Clin Chim Acta 271: 1 79-87

Standardization and clinical management of lipoprotein(a) measurements.

2009-02-02T14:02:39Z

The present article proposes personal suggestions to improve determinations and clinical interpretation of results of lipoprotein(a) assays. Methods and procedures for sampling and quantification of the various isoforms of lipoprotein(a) in serum, plasma and urine are reviewed with the aim of improving the reliability and reproducibility of results and reinforcing the clinical utility of lipoprote...

G Lippi, G Guidi (1998) Clin Chem Lab Med 36: 1 5-16

Effect of pyridoxal 5'-phosphate on human neutrophil respiratory burst and adhesion on serum coated microplates.

2009-02-02T14:02:39Z

The effect of pyridoxal 5'-phosphate (PP) on human polymorphonuclear leukocytes respiratory burst and on cellular adhesion on serum coated microplates was investigated. No dose-response effect was observed after 10 min pre-treatment at 37 degrees C of human neutrophils with increasing doses of PP, ranging from 0.05 mM/L to 0.5 mM/L. The production of superoxide anion (O2-), after challenging cells...

G Lippi, S Chirumbolo, G Guidi (1998) Biomed Pharmacother 52: 4 157-161

Usefulness of lipids, lipoprotein(a) and fibrinogen measurements in identifying subjects at risk of occlusive complications following vascular and endovascular surgery.

2009-02-02T14:02:39Z

The study was designed to establish the usefulness of measuring lipoprotein(a) [Lp(a)], total cholesterol, triglycerides, low-density lipoprotein [LDL]-cholesterol, high-density lipoprotein [HDL]-cholesterol, total-to-HDL-cholesterol ratio and fibrinogen in identifying subjects at risk of occlusive complications following vascular and endovascular surgery, including primary successful ileofemoral ...

G Lippi, G F Veraldi, V Dorucci, R Dusi, O Ruzzenente, C Brentegani, G Guidi, C Cordiano (1998) Scand J Clin Lab Invest 58: 6 497-504

Evaluation of the analytical performances of a new fully automated commercial immunonephelometric assay for lipoprotein(a).

2009-02-02T14:02:39Z

Several commercial methods have been proposed for lipoprotein(a) (Lp(a)) measurements over the past decades. However, only a few of them appear completely suitable in terms of analytical performance, costs and practicability. We evaluated the analytical performance of a new commercial fully automated immunonephelometric assay for Lp(a) measurements on the IMMAGE Immunochemistry System. Mean within...

G Lippi, O Ruzzenente, C Brentegani, A Pierotti, G Guidi (1998) Clin Chem Lab Med 36: 9 719-723

Clinical performance of leukocyte differential on the new Roche Cobas Vega haematological analyzer.

2009-02-02T14:02:39Z

The Roche Cobas Vega is a five-part differential haematological analyzer evolving from the former Cobas Helios, Argos and Micros. As the leukocyte differential of Cobas Vega displays several interesting features, we analyzed its clinical performance and compared it either to three other commercial haematological analyzers (Technicon-Bayer H*2, Coulter STKS and Abbott CD-3500) or to the manual refe...

G Lippi, M Nicoli, N Modena, G Guidi (1997) Eur J Clin Chem Clin Biochem 35: 2 105-110

Paradoxical behaviour of lyophilised commercial control materials for CK and CK-MB assays after reconstitution at either 4 degrees C or 24 degrees C.

2009-02-02T14:02:39Z

G Lippi, C Brentegani, C Cocco, C Lo Cascio, G Guidi (1997) Clin Chim Acta 261: 2 167-173

Evaluation of five new liquid stable applications on the Roche Cobas Integra.

2009-02-02T14:02:39Z

In the present study the analytical performances of five new liquid applications on the Roche Cobas Integra were evaluated: urea and high density lipoprotein (HDL) cholesterol in serum and glucose, creatinine and inorganic phosphorus in urine. The analytical evaluation consisted of imprecision, linearity and method comparison performed against either the actual Cobas Integra granulate applications...

G Lippi, C Brentegani, C Mazzi, C Recchi, O Ruzzenente, G Guidi (1997) Eur J Clin Chem Clin Biochem 35: 11 877-880

Effects of nandrolone decanoate (Decadurabolin) on serum Lp(a), lipids and lipoproteins in women with postmenopausal osteoporosis.

2009-02-02T14:02:39Z

Although lipoprotein(a) (Lp(a)) concentrations are mainly regulated genetically, it has been reported that variations in sex hormone concentrations may have effects on serum Lp(a). We evaluated the effect of nandrolone decanoate, a testosterone-derived synthetic anabolic steroid, on serum Lp(a), lipids and lipoproteins in 19 postmenopausal women who were given parenteral nandrolone decanoate (Deca...

G Lippi, G Guidi, O Ruzzenente, V Braga, S Adami (1997) Scand J Clin Lab Invest 57: 6 507-511

Serum paraoxonase activity is decreased in uremic patients.

2009-02-02T14:02:39Z

Paraoxonase is a high-density lipoprotein (HDL)-associated enzyme capable of hydrolysing lipid peroxides. We measured the activity of serum paraoxonase together with serum concentrations of a variety of lipid constituents--total cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL), cholesterol, triglycerides, apolipoproteins A-I and B--in 60 hemodialyzed (HD) patients. We ...

R Schiavon, E De Fanti, D Giavarina, S Biasioli, G Cavalcanti, G Guidi (1996) Clin Chim Acta 247: 1-2 71-80

Simple and rapid procedure for the purification of lipoprotein(a).

2009-02-02T14:02:39Z

Lipoprotein(a) [Lp(a)] is a low-density lipoprotein-like particle displaying strong athero-thrombotic properties. Highly purified Lp(a) is increasingly requested for standardization of Lp(a) measurements and for biological studies. Several procedures have been described for Lp(a) separation and purification but none of them appear completely suitable. We present here a procedure for Lp(a) purifica...

G Lippi, C Lo Cascio, O Ruzzenente, G Poli, C Brentegani, G Guidi (1996) J Chromatogr B Biomed Appl 682: 2 225-231

Effects of anticoagulants on lipoprotein(a) measurements with four commercial assays.

2009-02-02T14:02:39Z

Lipoprotein(a) levels in plasma are considered an independent risk factor for atherosclerosis at different sites. Although Lp(a) measurements have recently gained interest in clinical laboratories, several problems are still unresolved. A potential source of pre-analytical variability lies in the treatment of the specimens, since it has been reported that values of several lipid quantities are low...

G Lippi, L Giampaolo, G Guidi (1996) Eur J Clin Chem Clin Biochem 34: 3 251-255

Platelet count in EDTA-dependent pseudothrombocytopenia.

2009-02-02T14:02:39Z

G Lippi, G Guidi, M Nicoli (1996) Eur J Haematol 56: 1-2 112-113

Significant reduction of the bias among commercial immunoassays for lipoprotein(a) after use of a uniform calibrator.

2009-02-02T14:02:39Z

Despite the increasing interest in the measurements of lipoprotein(a) (Lp(a) in serum or plasma, at present there is no effective standardization for Lp(a) assays; the main problems to solve are represented either by the lack of a suitable primary standard or by the absence of a reliable and widely available reference method. A first step is hence the uniformity of calibration of different immunoa...

G Lippi, C Lo Cascio, O Ruzzenente, C Brentegani, G Guidi (1996) Clin Chim Acta 256: 2 125-134

Selenium status and plasma glutathione peroxidase in patients with IgA nephropathy.

2009-02-02T14:02:39Z

The abnormal proliferation of mesangial cells with IgA deposition in the glomeruli characterizes primitive mesangial glomerulonephritis (IgA nephropathy, IgAN); this disease reduces the normal renal parenchyma while renal function becomes progressively impaired. The possible role of selenium has never been considered in evaluating factors involved in the pathogenesis of IgAN. In this work we compa...

G Bellisola, G C Guidi, G Cinque, S Galassini, N Q Liu, G Moschini, C Rugiu, A Lupo (1996) J Trace Elem Med Biol 10: 3 189-196

Lipoprotein(a) immunoassays: comparison of a semi-quantitative latex method and two monoclonal enzyme immunoassays.

2009-02-02T14:04:41Z

Lipoprotein(a) is considered an independent risk factor for atherosclerosis. A variety of analytical methods have been proposed for lipoprotein(a) measurement, the majority of which require dedicated instruments and are costly to perform, particularly when the aim is to screen for high lipoprotein(a) concentrations in large populations. We evaluated the sensitivity and specificity of a newly devel...

S M Marcovina, G Lippi, G Guidi (1995) Int J Clin Lab Res 25: 4 201-204

Lipoprotein(a) and general risk factors in patients with angiographically assessed peripheral arterial disease.

2009-02-02T14:02:39Z

High lipoprotein(a) [Lp(a)] has been observed in patients with ischemic heart disease and cerebrovascular disease. Lp(a) is actually thought to be an independent risk factor for coronary disease. We therefore carried out a case-control study, evaluating plasma Lp(a) in 61 patients with angiographically documented peripheral arterial disease (PAD) and in 61 age- and sex-matched patients with no car...

M Prior, E Arosio, M Ferrari, L Lucchese, G C Guidi, O Bosello (1995) Int Angiol 14: 4 357-363

Semi-quantitative latex method for lipoprotein(a) assay.

2009-02-02T14:04:41Z

G Lippi, O Ruzzenente, R Facchinetti, G Guidi (1994) Clin Chim Acta 229: 1-2 147-151

The plasma glutathione peroxidase enzyme in hemodialyzed subjects.

2009-02-02T14:04:41Z

The kidney is probably the major site of production of the plasma enzyme glutathione peroxidase (GSHPx-P). For this study, GSHPx-P activity was determined in 40 healthy people, in 34 patients with differing degrees of renal impairment, and in hemodialysis patients from whom blood samples were withdrawn either before or after each session (18 patients) or throughout the dialysis session (27 patient...

R Schiavon, S Biasioli, E De Fanti, L Petrosino, L Cavallini, G Cavalcanti, A Zambello, G Guidi (1994) ASAIO J 40: 4 968-971

Plasma glutathione peroxidase activity as an index of renal function.

2009-02-02T14:04:41Z

The kidney is a major source of the plasma enzyme glutathione peroxidase. We measured plasma glutathione peroxidase activity in 130 patients affected with different renal diseases at various stages, and compared it with the following indices of kidney function: serum creatinine, creatinine clearance, and urinary excretion of alpha 1-microglobulin, beta 2-microglobulin, albumin and N-acetyl-beta-D-...

R Schiavon, G C Guidi, S Biasioli, E De Fanti, L Targa (1994) Eur J Clin Chem Clin Biochem 32: 10 759-765

Selenium enhances glutathione peroxidase activity and prostacyclin release in cultured human endothelial cells. Concurrent effects on mRNA levels.

2009-02-02T14:04:41Z

Selenium (Se) is an essential component of glutathione peroxidase (GSH-Px), an enzyme that protects cells by reducing intracellular peroxides. Impaired Se status and GSH-Px activity seem associated with increased risk of atherosclerotic vascular diseases. This study reports the effects of Se supplementation on GSH-Px activity, on prostacyclin (PGI2) production, on 12-hydroxy-eicosatetraenoic acid ...

M M Ricetti, G C Guidi, G Bellisola, R Marrocchella, A Rigo, G Perona (1994) Biol Trace Elem Res 46: 1-2 113-123

Plasma selenium and glutathione peroxidase activities in individuals living in the Veneto region of Italy.

2009-02-02T14:04:41Z

In order to assess the Se status in individuals living in the Veneto region, a series of related measurements was performed. These included plasma selenium by PIXE and glutathione-peroxidase (GSH-Px) activities in plasma, red blood cells and platelets. Individuals were either normals or people suffering from various liver diseases. Moreover, an oral supplement of sodium selenite was given to 13 pa...

G Bellisola, G Perona, S Galassini, G Moschini, G C Guidi (1993) J Trace Elem Electrolytes Health Dis 7: 4 242-244

Use of purified dermatan sulfate for heparin cofactor II (HC II) assay.

2009-02-02T14:04:41Z

HC II functional assays are generally preferred with respect to immunochemical assays. Nevertheless functional assays can be biased by the antithrombin III (AT III)-heparin complex activity; in fact trace amounts of heparin generally contaminate dermatan sulfate (DS) commercial preparations used as HC II reaction activators. We have employed a purified DS preparation showing these features: DS con...

O Ruzzenente, R Ghidini, G Poli, R Schiavon, G C Guidi (1992) Thromb Res 65: 2 281-287

Selenium and glutathione peroxidase variations induced by polyunsaturated fatty acids oral supplementation in humans.

2009-02-02T14:04:41Z

Serum and erythrocyte selenium, erythrocyte and platelet glutathione-peroxidase (GSH-Px) activities, and erythrocyte reduced glutathione (GSH) content were measured in 25 healthy adult individuals before and after daily supplementation with 20 ml of fish oil for 10 weeks. Serum-Se decreased from 0.83 +/- 0.01 mumol/l to 0.75 +/- 0.02 mumol/l (mean +/- S.E.M.) (P less than 0.01); erythrocyte-Se dec...

G Bellisola, S Galassini, G Moschini, G Poli, G Perona, G Guidi (1992) Clin Chim Acta 205: 1-2 75-85

Near infrared reflectance measurement of nitrogen faecal losses.

2009-02-02T14:04:41Z

Chemical methods of measuring nitrogen in stools are complex, unpleasant, and therefore rarely performed. Recently, near infrared reflectance (NIRA) has been suggested for stool analysis. The aim of this study was to evaluate the possible application of this method in routine faecal nitrogen measurement. Nitrogen concentration and daily output were measured in the stools of 83 patients using NIRA ...

L Benini, S Caliari, F Bonfante, G C Guidi, M T Brentegani, G Castellani, C Sembenini, E Bardelli, I Vantini (1992) Gut 33: 6 749-752

Serum ferritin and serum iron changes after cross-country and roller ski endurance races.

2009-02-02T14:04:41Z

We have studied the variations induced in iron status parameters by four endurance races of different lengths. A comprehensive group of 48 healthy, non-iron deficient, endurance athletes were evaluated before and after four different cross-country and roller ski races: I = Skirollonga, roller ski race for individuals (n = 10), mean duration (MD) = 1 h 48 min; II = Marcialonga, cross-country ski ra...

A Pattini, F Schena, G C Guidi (1990) Eur J Appl Physiol Occup Physiol 61: 1-2 55-60

Selenium supplementation increases renal glomerular filtration rate.

2009-02-02T14:04:41Z

Selenium (Se) is a trace element variously distributed in the human body and especially concentrated in certain organs, such as the renal cortex. We report results obtained during a ten weeks' oral Se supplementation. Experiments were devised to evaluate previous preliminary observations which suggested a possible effect of Se addition on the renal glomerular filtration rate. Eleven healthy volunt...

G C Guidi, G Bellisola, G Bonadonna, F Manzato, O Ruzzenente, R Schiavon, S Galassini, Q X Liu, H R Shao, G Moschini (1990) J Trace Elem Electrolytes Health Dis 4: 3 157-161

Selenium dependent glutathione peroxidase: a physiological regulatory system for platelet function.

2009-02-02T14:04:41Z

In human platelets the selenoenzyme glutathione peroxidase (GSH-Px) acts as a scavenger of the peroxides generated during the burst of arachidonic acid (AA) metabolism. Such a mechanism inhibits the biosynthesis of both thromboxane A2 (TXA2) and lipoxygenase products. The same mechanism is not effective on the prostacyclin (PGI2) biosynthesis from cultured endothelial cells. In order to evaluate t...

G Perona, R Schiavon, G C Guidi, D Veneri, P Minuz (1990) Thromb Haemost 64: 2 312-318

Near infrared spectrometry for faecal fat measurement: comparison with conventional gravimetric and titrimetric methods.

2009-02-02T14:04:41Z

This investigation was aimed at comparing a new method for measuring faecal fat excretion, carried out with a semi-automated instrument by using near infrared analysis (NIRA), with the traditional titrimetric (Van de Kamer) and gravimetric (Sobel) methods. Near infrared analysis faecal fat was assayed on the three day stool collection from 118 patients (68 chronic pancreatitis, 19 organic diseases...

L Benini, S Caliari, G C Guidi, B Vaona, G Talamini, I Vantini, L A Scuro (1989) Gut 30: 10 1344-1347

Computer assisted laboratory diagnosis: a ten-year experience.

2009-02-02T14:04:41Z

An automated procedure to help general practitioners in clinical diagnosis and decision making is presented. The computer-based program is conceived to process results from laboratory tests performed on outpatients, providing general practitioners with possible causes of abnormal results. When only one or two abnormal tests are observed, a series of suggestions pertinent to each abnormality is pri...

M Zatti, G Guidi, F Marcolini (1988) Int J Biomed Comput 23: 1-2 125-135

Clearance of maltose administered at different infusion rates.

2009-02-02T14:06:51Z

Maltose is a disaccharide consisting of 2 molecules of d-glucose which at 10% solution is isotonic with plasma but provides a caloric supply double than glucose. Its possible use in total parenteral nutrition was investigated. Two homogeneous groups of patients were infused during a 2-hour period with a 10% maltose solution at 0.2 g/kg/h and at 0.4 g/kg/h flow rate. The data collected during and a...

G Motton, F Ricci, A Arienzo, M Genna, L Azzolini, G C Guidi (1987) Ital J Surg Sci 17: 2 153-159

Adenine nucleotides and some related enzyme activities (adenylate kinase and phosphoglycerate kinase) in normal and abnormal human semen.

2009-02-02T14:06:51Z

Adenine nucleotides (ATP and ADP) and enzyme activities of Adenylate Kinase (AK) and Phosphoglycerate Kinase (PGK) were assayed on semen samples from normal and infertile men. In accordance with the values obtained, samples could be classified into two groups: one group with levels of either adenine nucleotides and enzymes assumed as normal; a second group with high levels of all the parameters. T...

G Dolcetta, E Busatta, P Sommacampagna, M Dusi, I Stoppelli, F Tomei, R Schiavon, D Olzer, G Guidi (1986) Andrologia 18: 2 184-189

Platelet glutathione peroxidase activity is impaired in patients with coronary heart disease.

2009-02-02T14:06:51Z

Platelet glutathione peroxidase (GSH-Px) activity was measured in 25 healthy individuals and in 25 patients affected with well-documented coronary artery stenosis. In parallel, malondialdehyde (MDA) production was assayed on platelets following stimulation with sodium arachidonate. Mean platelet GSH-Px activity was significantly reduced and mean platelet MDA production was significantly increased ...

G Guidi, R Schiavon, I Sheiban, G Perona (1986) Scand J Clin Lab Invest 46: 6 549-551

Severe impairment of antioxidant system in human hepatoma.

2009-02-02T14:06:51Z

Catalase (CAT), glutathione-peroxidase (GSH-Px) activity and reduced glutathione content (GSH) were measured in patients who had hepatocellular carcinoma, and values compared with those of normal liver and liver adjacent to neoplastic tissue. The results showed a remarkable reduction of CAT in tumor and corresponding tumor-free tissue (P less than 0.001 and P less than 0.02, respectively). All neo...

R Corrocher, M Casaril, G Bellisola, G B Gabrielli, N Nicoli, G C Guidi, G De Sandre (1986) Cancer 58: 8 1658-1662

Inhibition of erythrocyte glutathione-peroxidase by bromsulphalein.

2009-02-02T14:06:51Z

42 different samples of human erythrocytes were tested for glutathione-peroxidase activity (GSH-Px) in an attempt to study the inhibitory effect of Bromsulphalein (BSP). The mean activity of the enzyme was 11.90 +/- 3.61 U/g Hb, with no significant difference between males and females. BSP was used at different concentrations from 1 to 45 mM and inhibited GSH-Px activity; the inhibition curve show...

R Corrocher, M Casaril, G Bellisola, G C Guidi, G B Gabrielli, G De Sandre (1985) Acta Haematol 74: 4 222-226

Selenium enhances prostacyclin production by cultured endothelial cells: possible explanation for increased bleeding times in volunteers taking selenium as a dietary supplement.

2009-02-02T14:06:51Z

Selenium added to the culture medium of confluent pig aortic endothelial cells caused a time-related elevation in the activity of the hydroperoxide scavenging enzyme: glutathione peroxidase. This increased activity was associated with an enhanced ability to produce prostacyclin irregardless of whether the agonist was arachidonic acid or thrombin. Since prostacyclin synthetase is believed to be irr...

R Schiavon, G E Freeman, G C Guidi, G Perona, M Zatti, V V Kakkar (1984) Thromb Res 34: 5 389-396

The enzyme glutathione peroxidase in arachidonic acid metabolism of human platelets.

2009-02-02T14:06:51Z

We investigated the possible regulatory role of glutathione peroxidase on thromboxane formation by reducing peroxides in platelets. Experiments carried out in platelet lysates demonstrated that the burst of the arachidonate metabolism was accompanied by a simultaneous burst of hydrogen transfer from glutathione to peroxides, catalyzed by endogenous glutathione peroxidase. The burst of hydrogen tra...

G Guidi, R Schiavon, A Biasioli, G Perona (1984) J Lab Clin Med 104: 4 574-582

Sensitive salicylate assay in plasma with a 'reversed' Berthelot's reaction.

2009-02-02T14:06:51Z

G Guidi, D Olzer, R Schiavon, M Zatti (1983) Clin Chim Acta 131: 3 325-332

A new glucose 6-phosphate dehydrogenase variant (G-6-PD Verona) in a patient with myelodysplastic syndrome.

2009-02-02T14:06:51Z

A 67-year-old woman investigated because of 'myelodysplastic syndrome' was found to have a 4-fold increase in G-6-PD activity in her erythrocytes. The enzyme was partially purified and characterized. On grounds of: (a) reduced electrophoretic mobility, (b) abnormal cathodic band(s) in isoelectrofocusing, (c) increased Michaelis constant for glucose 6-phosphate, (d) abnormal thermostability, and (e...

G Perona, G C Guidi, D Tummarello, C Mareni, G Battistuzzi, L Luzzato (1983) Scand J Haematol 30: 5 407-414

Neonatal erythrocyte glutathione peroxidase deficiency as a consequence of selenium imbalance during pregnancy.

2009-02-02T14:06:51Z

The red blood cell (RBC) glutathione peroxidase (GSH-Px) activity and routine haematological parameters were measured in 38 healthy north Italian full-term pregnant women and in their newborn infants. In 31 pairs the serum selenium concentration was also measured. Data were compared with those of 20 normal adult controls (10 males and 10 females). Newborn infants exhibited significantly lower RBC ...

G Perona, G C Guidi, A Piga, R Cellerino, G Milani, P Colautti, G Moschini, B M Stievano (1979) Br J Haematol 42: 4 567-574

In vivo and in vitro variations of human erythrocyte glutathione peroxidase activity as result of cells ageing, selenium availability and peroxide activation.

2009-02-02T14:06:51Z

Cases showing erythrocyte glutathione peroxidase (GSH-Px) defects have been previously described. Our experiments demonstrate that a number of non genetic factors may influence the GSH-Px activity in human erythrocytes. Selenium administration in vivo was followed in four subjects by elevation in erythrocyte GSH-Px activity ranging from 30% to 1400%. Selenium operates mainly in the bone marrow ery...

G Perona, G C Guidi, A Piga, R Cellerino, R Menna, M Zatti (1978) Br J Haematol 39: 3 399-408

Erythrocytic glutathione peroxidase: its relationship to plasma selenium in man.

2009-02-02T14:06:51Z

Erythrocytic glutathione-peroxidase (GSH-Px) activity and plasma selenium concentrations were measured in 14 patients: 7 with iron deficiency and 7 with raised serum iron levels. The decreased enzymatic activity in iron deficiency was confirmed. Plasma selenium was significantly lower in patients with lower serum iron; furthermore there is a significant correlation between serum iron and plasma se...

G Perona, R Cellerino, G C Guidi, G Moschini, B M Stievano, C Tregnaghi (1977) Scand J Haematol 19: 1 116-120

Plasma iron and erythrocytic glutathione peroxidase activity. A possible mechanism for oxidative haemolysis in iron deficiency anemia.

2009-02-02T14:06:51Z

The red cell glutathione-peroxidase (GSH-Px) activity of 9 normal subjects is compared with that of 15 cases of iron deficiency anaemia and with 13 cases of heterozygous beta-thalassemia with the same degree of anaemia and hypochromia. 2 cases of sideroblastic anaemia with high serum iron levels were also examined. Enzymatic activity was found to be significantly decreased in iron deficiency anaem...

R Cellerino, G Guidi, G Perona (1976) Scand J Haematol 17: 2 111-116

A rapid photometric micromethod for serum lipase determination.

2009-02-02T14:06:51Z

U Lippi, G Stevanato, G Guidi (1972) Clin Chim Acta 37: 199-202

Biological diagnosis of primary liver cancer

2009-02-02T14:06:51Z

U Lippi, G Guidi (1972) Med Chir Dig 1: 4 185-188

Anomalous serum protein in hepatocarcinoma and hepatic metastases.

2009-02-02T14:06:51Z

U Lippi, A Villa, R Pavan, G Guidi (1971) Am J Clin Pathol 56: 2 227-229

A new colorimetric ultramicromethod for serum glutamic-oxalacetic and glutamic-pyruvic transaminase determination.

2009-02-02T14:06:51Z

U Lippi, G Guidi (1970) Clin Chim Acta 28: 3 431-437

Improvement of a new SGOT and SGPT ultramicro method. Calibration procedure.

2009-02-02T14:06:51Z

U Lippi, G Guidi, R Pavan (1970) Clin Chim Acta 30: 3

Lysosome lesions from high doses of ascorbic acid

2009-02-02T14:08:10Z

U Lippi, E Pulido, G Guidi (1966) Acta Vitaminol 20: 5 177-180