http://publicationslist.org/data/guy.huel/atom.xml Huel Guyhttp://publicationslist.org/guy.huel$basepathfavicon.icoRecent additions to Huel Guy's PublicationsList.org pagehttp://publicationslist.org/publications.png2010-02-24T15:10:51Z http://publicationslist.org/guy.huel/refid3 2010-02-24T15:05:05Z

Selenium (Se) is an essential element and deficit or excess of dietary Se is associated with health disorders. Relatively elevated Se levels have been reported in the Brazilian Amazon, where there are also important annual variations in the availability of different foods. The present study was conducted among six riparian communities of the Tapajós River to evaluate seasonal variations in blood ...<br/><br/>Melanie Lemire, Donna Mergler, Guy Huel, Carlos J S Passos, Myriam Fillion, Aline Philibert, Jean R D Guimarães, Isabelle Rheault, Julie Borduas, Gabrielle Normand (2009) <i>J Expo Sci Environ Epidemiol</i> <i></i> <i></i> 19: 2 213-222<br/>

http://publicationslist.org/guy.huel/refid2 2010-02-24T15:05:05Z

BACKGROUND: Environmental prenatal exposure to potentially neurotoxic metals poses a particular challenge with regard to the study of early toxic effects. Monoamine oxidase activity, shown to be influenced by metals in experimental studies, could be a useful biomarker in humans. OBJECTIVE: To examine the relationship between blood metal concentrations at delivery and placenta MAO activity. METHODS...<br/><br/>Nadia Abdelouahab, Guy Huel, Alexander Suvorov, Bernard Foliguet, Valérie Goua, Ginette Debotte, Josianne Sahuquillo, Marie-Aline Charles, Larissa Takser (2009) <i>Neurotoxicol Teratol</i> <i></i> <i></i> : <br/>

http://publicationslist.org/guy.huel/refid1 2010-02-24T15:05:05Z

BACKGROUND: Prior studies revealed associations of environmental lead exposure with risks of hypertension and elevated blood pressure. OBJECTIVE: We examined the effect of blood lead levels on blood pressure and the incidence of pregnancy-induced hypertension (PIH) in the second and third trimesters of pregnancy. METHODS: One thousand seventeen pregnant women were enrolled in two French municipali...<br/><br/>Chadi Yazbeck, Olivier Thiebaugeorges, Thierry Moreau, Valérie Goua, Ginette Debotte, Josiane Sahuquillo, Anne Forhan, Bernard Foliguet, Guillaume Magnin, Rémy Slama, Marie-Aline Charles, Guy Huel (2009) <i>Environ Health Perspect</i> <i></i> <i></i> 117: 10 1526-1530<br/>

http://publicationslist.org/guy.huel/refid4 2010-02-24T15:05:05Z

BACKGROUND: Calcium homeostasis is a known target of several environmental toxicants including lead and mercury. OBJECTIVE: Our goal was to determine the relationship between Hg exposure and erythrocyte Ca pump activity in women at delivery and in their newborns. METHODS: We determined total Hg as well as Pb concentrations in 81 hair and blood samples obtained at delivery. Basal and calmodulin-sti...<br/><br/>Guy Huel, Josiane Sahuquillo, Ginette Debotte, Jean-François Oury, Larissa Takser (2008) <i>Environ Health Perspect</i> <i></i> <i></i> 116: 2 263-267<br/>

http://publicationslist.org/guy.huel/refid5 2010-02-24T15:05:05Z

Manganese (Mn) is widely distributed in the biosphere but occurs in only trace amounts in animal tissues. Although Mn deficiency and toxicity both have pathological consequences, the underlying biochemical lesions have not been well defined. In vitro studies suggest that transport proteins are affected by Mn, lead (Pb), and selenium (Se). Among these transport proteins, the calmodulin-regulated ca...<br/><br/>Chadi Yazbeck, Thierry Moreau, Josiane Sahuquillo, Larissa Takser, Guy Huel (2006) <i>Sci Total Environ</i> <i></i> <i></i> 354: 1 28-34<br/>

http://publicationslist.org/guy.huel/refid6 2010-02-24T15:05:05Z

OBJECTIVE: To evaluate health impact of boron in drinking water. METHODS: A regional scale geographical study in Northern France was conducted. Assessment of boron blood levels in a group of 180 healthy individuals and correlation with boron content in drinking water were followed by an assessment of health indicators such as birth rates, mortality rates, and sex ratios in zones of different boron...<br/><br/>Chadi Yazbeck, Wolfram Kloppmann, Roger Cottier, Josiane Sahuquillo, Ginette Debotte, Guy Huel (2005) <i>Environ Geochem Health</i> <i></i> <i></i> 27: 5-6 419-427<br/>

http://publicationslist.org/guy.huel/refid7 2010-02-24T15:05:05Z

Following boron intake, multiple effects have been observed in animal experiments. However, human data is lacking, and no data is available on the ability of boron to accumulate in fetal tissues. Positive responses in animal species suggest that developmental toxicity may be an area of concern in humans, following exposure to boron. Two hypotheses have seemed to account for the multiple effects de...<br/><br/>Guy Huel, Chadi Yazbeck, Daniel Burnel, Pascale Missy, Wolfram Kloppmann (2004) <i>Toxicol Sci</i> <i></i> <i></i> 80: 2 304-309<br/>

http://publicationslist.org/guy.huel/refid11 2010-02-24T15:05:05Z

BACKGROUND: Lead exposure and total immunoglobulin E (IgE) have been shown to be positively related in animals and humans even at lead levels below those recognized as toxic. In the last decades, exposure to lead has become more frequent in urban areas of industrialized as well as of developing countries where IgE-mediated allergy prevalence has also increased. METHODS: We examined for the first t...<br/><br/>I Annesi-Maesano, R Pollitt, G King, J Bousquet, G Hellier, J Sahuquillo, G Huel (2003) <i>Allergy</i> <i></i> <i></i> 58: 7 589-594<br/>

http://publicationslist.org/guy.huel/refid9 2010-02-24T15:05:05Z

The monoamine and intracellular calcium systems are two major elements of nervous system functions. However, their role in human brain development is unclear. We studied the association between activity of monoamine and intracellular calcium systems during prenatal life and subsequent psychomotor performances in healthy children. We used prospective data from 247 children followed from birth throu...<br/><br/>Larissa Takser, Dave Campagna, Phillippe Blot, Guy Huel (2003) <i>Pediatr Res</i> <i></i> <i></i> 54: 3 358-363<br/>

http://publicationslist.org/guy.huel/refid8 2010-02-24T15:05:05Z

Several studies have demonstrated neurobehavioral impairment related to manganese (Mn) exposure in the workplace. Exposure to high doses of manganese is associated with irreversible neurodegenerative disorders resembling idiopathic Parkinson disease. Although there is a risk of Mn accumulation in the foetus during pregnancy, little information exists about developmental effects of environmental lo...<br/><br/>Larissa Takser, Donna Mergler, Georgette Hellier, Josiane Sahuquillo, Guy Huel (2003) <i>Neurotoxicology</i> <i></i> <i></i> 24: 4-5 667-674<br/>

http://publicationslist.org/guy.huel/refid12 2010-02-24T15:06:51Z

Little is known about biochemical mechanisms associated with the normal psychomotor development of children. Many factors of the fetal environment likely interfere with these mechanisms. A prospective cohort study is essential to explain the implications of certain disturbances of biochemical nature during gestation on the later development of the nervous system. The study that we undertook with t...<br/><br/>G Huel, L Takser, J Sahuquillo, F Girard, G Hellier, P Blot (2003) <i>Rev Epidemiol Sante Publique</i> <i></i> <i></i> 51: 1 Pt 2 167-174<br/>

http://publicationslist.org/guy.huel/refid13 2010-02-24T15:06:51Z

BACKGROUND: The aim of the Council Directive of 29 March 1977 of the European Union was to measure non-occupational lead exposure levels in the general adult populations of European countries through biological monitoring. In France, such measurements were carried out during 1979 and 1982 in eight metropolitan areas (having more than 500 000 inhabitants), a period during which the lead content of ...<br/><br/>G Huel, N Fréry, L Takser, M Jouan, G Hellier, J Sahuquillo, J P Giordanella (2002) <i>Rev Epidemiol Sante Publique</i> <i></i> <i></i> 50: 3 287-295<br/>

http://publicationslist.org/guy.huel/refid14 2010-02-24T15:06:51Z

Manganese (Mn) and lead (Pb) are two neurotoxic chemicals and experimental evidence suggests that they can cross the placental barrier. Tetraethyl lead was still in use as an antiknock agent in Paris during the sampling period of the study, while it has been replaced by methylcyclopentadienyl manganese tricarbonyl (MMT) in Canada since 1977. By 1990, MMT was in 100% of gasoline in Canada. In a stu...<br/><br/>Audrey Smargiassi, Larissa Takser, André Masse, Martin Sergerie, Donna Mergler, Geneviève St-Amour, Philippe Blot, Georgette Hellier, Guy Huel (2002) <i>Sci Total Environ</i> <i></i> <i></i> 290: 1-3 157-164<br/>

http://publicationslist.org/guy.huel/refid10 2010-02-24T15:06:51Z

Studies of predictive factors of manual dexterity in adolescents and young adults are lacking. The present longitudinal study reports the relationship between cognitive and behavioural assessments at age 7 years and the schooling, cognitive performance, and manual dexterity at age 17 years. The participants were 65 schoolchildren, 30 boys and 35 girls, from a rural area in France. Assessment at ag...<br/><br/>Larissa Takser, Georges Dellatolas, Rosemarie Bowler, Nathalie Laplante, Guy Huel (2002) <i>Percept Mot Skills</i> <i></i> <i></i> 95: 1 15-26<br/>

http://publicationslist.org/guy.huel/refid15 2010-02-24T15:06:51Z

We examined the relationship between acquired color vision loss and exposure to toluene and total hydrocarbons among 125 male workers. Seventy-two toluene-exposed printers were compared with 34 workers from the same photogravure plant with ambient background exposure, and with 19 workers from a bookbinding plant located in the same town (nonexposed). Environmental mean toluene exposure level at wo...<br/><br/>D Campagna, B Stengel, D Mergler, J C Limasset, F Diebold, D Michard, G Huel (2001) <i>Neurotoxicol Teratol</i> <i></i> <i></i> 23: 5 473-480<br/>

http://publicationslist.org/guy.huel/refid17 2010-02-24T15:06:51Z

Selenium (Se), an essential trace element in human nutrition, is thought to have an important role in the prevention of oxygen damage by organic hydroperoxides generated by oxidative metabolism. Epidemiological studies have shown an association between placental cytochrome P450-1A1 (CYP1) activity and threatened preterm delivery (TPD), and other experimental studies have shown alterations in fetal...<br/><br/>G Huel, D Campagna, F Girard, T Moreau, P Blot (2000) <i>Environ Res</i> <i></i> <i></i> 84: 3 228-233<br/>

http://publicationslist.org/guy.huel/refid16 2010-02-24T15:06:51Z

Lead poisoning induces hematological, gastrointestinal and neurological dysfunctions. One of the potential mechanisms is the inhibition of calcium-pump (Ca-pump), a transport protein. We investigated the effects of an environmental low lead exposure on Ca-pump activity in 247 mothers and their newborns. Maternal and cord blood, and newborn and mother hair, were sampled at delivery. Geometric means...<br/><br/>D Campagna, G Huel, G Hellier, F Girard, J Sahuquillo, A Fagot-Campagna, J Godin, P Blot (2000) <i>Life Sci</i> <i></i> <i></i> 68: 2 203-215<br/>

http://publicationslist.org/guy.huel/refid19 2010-02-24T15:06:51Z

The objective of this work is to investigate the neurotoxicty of low-level lead exposure in utero on infants and the possible involvement of dopaminergic and serotonergic neurotransmitters. The correlation analysis for cord blood lead level, the concentrations of dopamine metabolite homovanillic acid (HVA) and serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in cord plasma and the neurodev...<br/><br/>H W Tang, G Huel, D Campagna, G Hellier, C Boissinot, P Blot (1999) <i>J Appl Toxicol</i> <i></i> <i></i> 19: 3 167-172<br/>

http://publicationslist.org/guy.huel/refid18 2010-02-24T15:06:51Z

The hypothesis that environmental lead exposure measured from blood (Pb-B) inhibits delta-aminolevulinic acid dehydratase activity (ALA-D) from whole blood was tested in 241 urban mothers and their newborns. Geometric means and (5th and 95th Percentiles) for maternal and cord Pb-B were 6.4 microg dl(-1) (3.4-11.9) and 4.6 microg dl(-1) (2.8-9.2). Spearman correlations between mother and cord Pb-B ...<br/><br/>D Campagna, G Huel, F Girard, J Sahuquillo, P Blot (1999) <i>Toxicology</i> <i></i> <i></i> 134: 2-3 143-152<br/>

http://publicationslist.org/guy.huel/refid20 2010-02-24T15:06:51Z

BACKGROUND: A recent study reported an association between a large head circumference at birth and adult total IgE. However, no study has yet looked at the relation between head circumference and cord blood IgE. OBJECTIVES: To assess the relationship between child's cord blood total IgE and head circumference at birth taking parental allergy and smoking habits as well as placental calcifications i...<br/><br/>M P Oryszczyn, I Annesi-Maesano, D Campagna, J Sahuquillo, G Huel, F Kauffmann (1999) <i>Clin Exp Allergy</i> <i></i> <i></i> 29: 3 334-341<br/>

http://publicationslist.org/guy.huel/refid21 2010-02-24T15:06:51Z

The purpose of this survey was to assess the health status of community residents exposed to a 16-day release of Catacarb from a nearby refinery and to document the prevalence rates of symptoms and illnesses of this town. The health status of the exposed residents was compared to that of unexposed residents of a demographically similar control town. An epidemiologic study design was used and quest...<br/><br/>R M Bowler, L Ngo, C Hartney, K Lloyd, I Tager, J Midtling, G Huel (1997) <i>Environ Res</i> <i></i> <i></i> 72: 2 93-108<br/>

http://publicationslist.org/guy.huel/refid24 2010-02-24T15:06:51Z

Styrene represents nowadays one of the most used organic solvent. The current exposure limit proposed for this chemical differs significantly from country to country: the Threshold Limit Value-Time Weighted Average (TLV-TWA) proposed by the American Conference of Governmental Industrial Hygienists (ACGIH) is 50 ppm while the German, Finnish and Swedish occupational exposure limit is 20 ppm. Nevert...<br/><br/>D Campagna, F Gobba, D Mergler, T Moreau, C Galassi, A Cavalleri, G Huel (1996) <i>Neurotoxicology</i> <i></i> <i></i> 17: 2 367-373<br/>

http://publicationslist.org/guy.huel/refid23 2010-02-24T15:06:51Z

The results of a symptom checklist of three matched-pair studies (N = 460) of the following exposed groups are presented: Study 1, a primarily white community (N = 220) environmentally exposed to the pesticide metam sodium; Study 2, a Hispanic group (N = 180) who worked in a microelectronics plant and had extensive past exposure (M = 6.7 yrs) to multiple organic hydrocarbon solvents; and Study 3, ...<br/><br/>R M Bowler, G Huel, D Mergler, J E Cone, S S Rauch, C Hartney (1996) <i>Neurotoxicology</i> <i></i> <i></i> 17: 3-4 793-802<br/>

http://publicationslist.org/guy.huel/refid22 2010-02-24T15:06:51Z

Surveillance of early neurotoxic alterations was undertaken in 3 reinforced plastics plants, with a view to preventive intervention. Using a longitudinal study design, exposure parameters (environmental styrene in the respiratory zone of each worker and end-shift mandelic acid (MA)) and neurobehavioral performance (Neurobehavioral Core Test Battery and Field Assessment: Sensory Tests), were assess...<br/><br/>D Mergler, G Huel, S Bélanger, R M Bowler, G Truchon, D Drolet, C Ostiguy (1996) <i>Neurotoxicology</i> <i></i> <i></i> 17: 3-4 803-812<br/>

http://publicationslist.org/guy.huel/refid28 2010-02-24T15:06:51Z

Selenium (Se) in high doses has been known to cause injury to the fetus and newborn. The major difficulty in assessing the effects of selenium on human reproduction stems from the need for a suitable means of estimating maternal and fetal exposure. The present investigation, therefore, examines the respective reliability of maternal plasma, cord plasma and placenta as epidemiological indicators as...<br/><br/>A M Lee, G Huel, J Godin, G Hellier, J Sahuquillo, T Moreau, P Blot (1995) <i>Sci Total Environ</i> <i></i> <i></i> 159: 2-3 119-127<br/>

http://publicationslist.org/guy.huel/refid27 2010-02-24T15:06:51Z

G Huel, D Campagna, T Moreau, P Tubert-Bitter (1995) <i>BMJ</i> <i></i> <i></i> 310: 6976 397-398<br/>

http://publicationslist.org/guy.huel/refid25 2010-02-24T15:06:51Z

The relationship between organic solvent exposure and central nervous disorders make early detection of neurophysiologic et neuropsychologic alterations in organic solvent exposed workers a priority. Moreover, the variability in the frequency of exposure and the numerous organic solvents encountered in scientific laboratories render the environmental and biological measurements used in medical sur...<br/><br/>D Campagna, D Mergler, A Picot, J Sahuquillo, S Belanger, C Pleven, A Brun, M P Leclerc-Marzin, G Lamotte, G Huel (1995) <i>Rev Epidemiol Sante Publique</i> <i></i> <i></i> 43: 6 519-532<br/>

http://publicationslist.org/guy.huel/refid26 2010-02-24T15:06:51Z

OBJECTIVES--The present study was undertaken to examine the relation between visual functions and occupational exposure to styrene. METHODS--A total of 128 workers (85% of the total population), from three glass-reinforced plastics plants in Canada, agreed to participate in the study. Environmental and biological measures were made on the day(s) prior to the assessment of near visual acuity (Natio...<br/><br/>D Campagna, D Mergler, G Huel, S Bélanger, G Truchon, C Ostiguy, D Drolet (1995) <i>Scand J Work Environ Health</i> <i></i> <i></i> 21: 5 382-390<br/>

http://publicationslist.org/guy.huel/refid29 2010-02-24T15:06:51Z

Psychological, psychosocial, and psychophysiological sequelae were studied in a community which had experienced a railroad chemical spill of 19,000 gallons of the toxic pesticide metam sodium. Two hundred twenty exposed residents were compared to 114 controls and paired on age, education, gender, race, and number of children. A clinical interview and physiological measurements (blood pressure, pul...<br/><br/>R M Bowler, D Mergler, G Huel, J E Cone (1994) <i>J Trauma Stress</i> <i></i> <i></i> 7: 4 601-624<br/>

http://publicationslist.org/guy.huel/refid30 2010-02-24T15:06:51Z

Neurological disorders, bearing many similarities to Parkinson's disease, have been associated with environmental and occupational exposure to manganese (Mn). To document early nervous system dysfunction associated with long-term exposure to Mn, a battery of neurofunctional tests was administered to workers employed in Mn alloy production. Study participation was 95% (n = 115). A matched pair desi...<br/><br/>D Mergler, G Huel, R Bowler, A Iregren, S Bélanger, M Baldwin, R Tardif, A Smargiassi, L Martin (1994) <i>Environ Res</i> <i></i> <i></i> 64: 2 151-180<br/>

http://publicationslist.org/guy.huel/refid31 2010-02-24T15:06:51Z

Psychological, and psychophysiological sequelae were studied in a community which had experienced a railroad chemical spill of 19,000 gallons of the toxic pesticide metam sodium. Information was collected on 350 persons living in the area of the spill (spill residents) and 114 nonexposed controls, recruited using a randomized sampling strategy, from a nearby similar, but unexposed control town. Ps...<br/><br/>R M Bowler, D Mergler, G Huel, J E Cone (1994) <i>Neurotoxicology</i> <i></i> <i></i> 15: 3 723-729<br/>

http://publicationslist.org/guy.huel/refid34 2010-02-24T15:06:51Z

Induction of aryl hydrocarbon hydroxylase (AHH) activity in the placenta has been well documented. This enzyme may be induced by a variety of Polycyclic Aromatic Hydrocarbons (PAHs) and the AHH inducibility is associated with harmful effects of environmental chemicals. Toxic effects of PAHs in tissues such as placenta have been demonstrated to be due to their metabolites, epoxides, which interact ...<br/><br/>G Huel, J Godin, N Frery, F Girard, T Moreau, C Nessmann, P Blot (1993) <i>J Expo Anal Environ Epidemiol</i> <i></i> <i></i> 3 Suppl 1: 187-199<br/>

http://publicationslist.org/guy.huel/refid33 2010-02-24T15:06:51Z

Fetal toxicity of cadmium (Cd) is well documented in rodents. However, little information is available regarding the human fetus. To investigate the effect of low levels of Cd on the human placenta and the consequences on birthweight, we conducted a study of 102 mothers and their newborns in an obstetrical care unit. Placental and hair samples were collected at delivery to determine Cd concentrati...<br/><br/>N Fréry, C Nessmann, F Girard, J Lafond, T Moreau, P Blot, J Lellouch, G Huel (1993) <i>Toxicology</i> <i></i> <i></i> 79: 2 109-118<br/>

http://publicationslist.org/guy.huel/refid32 2010-02-24T15:06:51Z

N Fréry, F Girard, T Moreau, P Blot, J Sahuquillo, S Hajem, G Orssaud, G Huel (1993) <i>Bull Environ Contam Toxicol</i> <i></i> <i></i> 50: 5 736-743<br/>

http://publicationslist.org/guy.huel/refid36 2010-02-24T15:06:51Z

Induction of aryl hydrocarbon hydroxylase (AHH) activity in the placenta as a result of maternal exposure to polycyclic aromatic hydrocarbons contained in cigarette smoke has been well documented. Furthermore, calcifications are more prevalent in the placentas of pregnant smokers than in those of non-smokers. The present study examines whether this latter relationship could be explained by the ind...<br/><br/>G Huel, F Girard, C Nessmann, J Godin, P Blot, G Bréart, T Moreau (1992) <i>Toxicology</i> <i></i> <i></i> 71: 3 257-266<br/>

http://publicationslist.org/guy.huel/refid37 2010-02-24T15:06:51Z

A prospective study has been carried out to assess the psychomotor deficit resulting from a moderate decrease in gestational age and pre-natal lead exposure. The general cognitive index of the McCarthy psychometric scale (adjusted for confounders) in six-year-old children was related to gestational age. Most of the psychomotor scores showed smoothing variations with gestational age ranging from 37...<br/><br/>G Huel, P Tubert, N Frery, T Moreau, J Dreyfus (1992) <i>Neurotoxicology</i> <i></i> <i></i> 13: 1 249-254<br/>

http://publicationslist.org/guy.huel/refid35 2010-02-24T15:06:51Z

Vitamin B12 (Cobalamin) is an essential nutrient in the diet of humans, particularly during pregnancy, nevertheless very few epidemiological studies have been reported, particularly concerning variation factors. The purpose of this study is to assess the role of vitamin B12 on birthweight after taking into account potential confounders, such as obstetrical, socioeconomic, and biological factors wh...<br/><br/>N Fréry, G Huel, M Leroy, T Moreau, R Savard, P Blot, J Lellouch (1992) <i>Eur J Obstet Gynecol Reprod Biol</i> <i></i> <i></i> 45: 3 155-163<br/>

http://publicationslist.org/guy.huel/refid40 2010-02-24T15:06:51Z

Although chemicals posing potential neurotoxic hazards are commonly used in the microelectronics industry, there has been no systematic study of possible chronic nervous system effects in microelectronics workers. The objective of the present study was to assess neuropsychological functions of a group of former microelectronics plant assembly workers and a group of referents, using a matched pair ...<br/><br/>R M Bowler, D Mergler, G Huel, R Harrison, J Cone (1991) <i>Neurotoxicology</i> <i></i> <i></i> 12: 1 87-103<br/>

http://publicationslist.org/guy.huel/refid39 2010-02-24T15:06:51Z

Although known neurotoxins with potential ophthalmotoxic properties are commonly used in microelectronics assembly, there has been no systematic study of visual disturbances among past or present workers in this industry. The objective of the present study was to compare visual functions, using a matched-pair design, between former workers from a microelectronics plant and a local reference popula...<br/><br/>D Mergler, G Huel, R Bowler, B Frenette, J Cone (1991) <i>Arch Environ Health</i> <i></i> <i></i> 46: 6 326-334<br/>

http://publicationslist.org/guy.huel/refid38 2010-02-24T15:06:51Z

S Hajem, P Hannaert, T Moreau, J Lellouch, G Huel, G Orssaud, F Girard, J Sahuquillo, J R Claude, R P Garay (1991) <i>Bull Environ Contam Toxicol</i> <i></i> <i></i> 47: 6 850-857<br/>

http://publicationslist.org/guy.huel/refid43 2010-02-24T15:06:51Z

Microelectronics assembly entails complex processes where several potentially fetotoxic chemical compounds are used extensively. This study was undertaken to assess the potential adverse reproductive outcomes among former women workers in a microelectronics assembly plant in New Mexico with respect to a comparable population from the same geographical region and to examine the relation between the...<br/><br/>G Huel, D Mergler, R Bowler (1990) <i>Br J Ind Med</i> <i></i> <i></i> 47: 6 400-404<br/>

http://publicationslist.org/guy.huel/refid42 2010-02-24T15:06:51Z

The relationships between five erythrocyte cation transport systems (Na(+)-K+ pump, Na(+)-K+ cotransport, Na(+)-Li+ countertransport and Na+ and K+ passive permeabilities) and plasma lipids (total plasma cholesterol, high-density lipoprotein cholesterol and triglycerides) were investigated in 129 male adult subjects with no known history of hypertension. Na+ and K+ erythrocyte contents were also c...<br/><br/>S Hajem, T Moreau, P Hannaert, J Lellouch, G Orssaud, G Huel, J R Claude, R P Garay (1990) <i>J Hypertens</i> <i></i> <i></i> 8: 10 891-896<br/>

http://publicationslist.org/guy.huel/refid41 2010-02-24T15:06:51Z

Red cell cation transports (Na(+)-K+ pump, Na(+)-K+ cotransport system, Na(+)-Li+ countertransport, and Na+ and K+ passive permeabilities) and blood and hair lead levels were measured in 129 healthy adult Caucasians not occupationally exposed to lead. In agreement with previously reported in vitro results showing a lead-induced Na(+)-K+ ATPase inhibition, Na(+)-K+ pump activity was inversely corre...<br/><br/>S Hajem, T Moreau, P Hannaert, J Lellouch, G Huel, G Hellier, G Orssaud, J R Claude, B Juguet, B Festy (1990) <i>Environ Res</i> <i></i> <i></i> 53: 2 105-118<br/>

http://publicationslist.org/guy.huel/refid44 2010-02-24T15:06:51Z

The levels of smoke components and metabolites in maternal blood and urine are useful in assessing direct exposure but they do not appear to be sufficiently sensitive as a long-term indicator of passive smoke exposure. Induction of aryl hydrocarbon hydroxylase (AHH) activity in the placenta as a result of maternal smoking has been well documented. This enzyme oxidizes various polycyclic aromatic h...<br/><br/>G Huel, J Godin, T Moreau, F Girard, J Sahuquillo, G Hellier, P Blot (1989) <i>Environ Res</i> <i></i> <i></i> 50: 1 173-183<br/>

http://publicationslist.org/guy.huel/refid45 2010-02-24T15:06:51Z

G Huel, E Keller, S Gueguen, C Robert, J Bouyer, E Papiernik, N Mamelle, B Laumon, F Munoz, D Collin (1989) <i>Birth Defects Orig Artic Ser</i> <i></i> <i></i> 25: 1 1-234<br/>

http://publicationslist.org/guy.huel/refid46 2010-02-24T15:06:51Z

This paper reports an investigation of blood pressure (taken as a continuous variable) as a function of: erythrocyte Na+ content; Na+,K+ pump; Na+,K+ cotransport and Na+,Li+ countertransport fluxes, and passive cation permeabilities in fresh erythrocytes from 129 French males who were living in an urban area and were not under treatment for any medical condition (after allowing for the effects of ...<br/><br/>P A Hannaert, T Moreau, G Huel, G Orssaud, J Lellouch, J R Claude, J Sahuquillo, R P Garay (1988) <i>J Hypertens</i> <i></i> <i></i> 6: 11 905-911<br/>

http://publicationslist.org/guy.huel/refid47 2010-02-24T15:06:51Z

Five red blood cell cation transport systems (RBCTS), together with blood lead level and blood pressure, were measured in 129 male adult subjects who were not occupationally exposed to lead or subsequent to a course of treatment for hypertension. Blood lead was positively related with systolic blood pressure, and to a lesser degree with diastolic blood pressure. Blood lead was found significantly ...<br/><br/>T Moreau, P Hannaert, G Orssaud, G Huel, R P Garay, J R Claude, B Juguet, B Festy, J Lellouch (1988) <i>Environ Health Perspect</i> <i></i> <i></i> 78: 47-51<br/>

http://publicationslist.org/guy.huel/refid50 2010-02-24T15:06:51Z

Blood samples to be analysed for lead, cadmium and mercury were taken from 417 pregnant women not occupationally exposed to these metals. Each subject was paired with a non-pregnant woman of the same age (+/- 2 years), socio-economic status, alcohol and tobacco status. Most of the inter-individual variations observed in earlier studies were confirmed in the control group. Among the pregnant women,...<br/><br/>C Bonithon-Kopp, G Huel, C Grasmick, H Sarmini, T Moreau (1986) <i>Biol Res Pregnancy Perinatol</i> <i></i> <i></i> 7: 1 37-42<br/>

http://publicationslist.org/guy.huel/refid49 2010-02-24T15:06:51Z

In geographical epidemiology, the correlation between two variables is often studied, using as basic units those zones for which these variables are available. However, because of their geographical contiguity, it could be misleading to consider each of these zones as independent statistical units. Moreover, spatial distributions (either of the factor or of the disease) are often distributed in re...<br/><br/>G Huel, J F Petiot, P Lazar (1986) <i>Stat Med</i> <i></i> <i></i> 5: 2 171-181<br/>

http://publicationslist.org/guy.huel/refid48 2010-02-24T15:06:51Z

In 1977, a hair sample was taken from 26 newborn babies and their mothers and analysed for lead and cadmium. Six years later, each of these 26 children was given a psychometric test (McCarthy Scales of Children's Abilities). Statistical analysis shows a significant negative relationship between the degree of in utero exposure to cadmium and lead and the child's motor and perceptual abilities. Any ...<br/><br/>C Bonithon-Kopp, G Huel, T Moreau, R Wendling (1986) <i>Neurobehav Toxicol Teratol</i> <i></i> <i></i> 8: 3 307-310<br/>

http://publicationslist.org/guy.huel/refid51 2010-02-24T15:06:51Z

The aim of the council directive of 29 March 1977 of the European Community (1) is the screening for non-work-related lead exposure levels in the general populations of European (member) countries. In France, such testing was carried out in eight metropolitan areas (having more than 500,000 inhabitants), another eight "critical" areas surrounding industrial emission sources and one area (Vosges) h...<br/><br/>G Huel, C Boudène, M Jouan, P Lazar (1986) <i>Int Arch Occup Environ Health</i> <i></i> <i></i> 58: 2 131-139<br/>

http://publicationslist.org/guy.huel/refid52 2010-02-24T15:06:51Z

This study deals with the person-to-person variation in the levels of lead and cadmium in the blood of 6437 subjects (2883 men and 3554 women). The lead level (Pb-B) is clearly higher in men than in women, and the cadmium level (Cd-B) is a little higher in men than in women. Only the Pb-B varies according to age for both sexes. The results reveal that the consumption of alcohol could play an impor...<br/><br/>C Grasmick, G Huel, T Moreau, H Sarmini (1985) <i>Sci Total Environ</i> <i></i> <i></i> 41: 3 207-217<br/>

http://publicationslist.org/guy.huel/refid53 2010-02-24T15:06:51Z

Newborn and maternal hair samples were obtained from subjects occupationally exposed to heavy metals and from matched controls. The geometric means of levels of cadmium and lead in hair from exposed mothers and of cadmium in hair from transplacentally exposed newborns were twice as high as levels present in samples from controls. There was a positive correlation between levels of cadmium in matern...<br/><br/>G Huel, R B Everson, I Menger (1984) <i>Environ Res</i> <i></i> <i></i> 35: 1 115-121<br/>

http://publicationslist.org/guy.huel/refid55 2010-02-24T15:06:51Z

The blood lead levels of 1.877 persons living in 8 large French cities or in their suburbs were measured. Blood lead level varies with sex, age, tobacco, wine consumption and date of construction of the house. The specific effect of each of these variables can be quantified. The slope of the regression of blood lead level on age is approximatively 1 microgram/dl per 14 years. Blood lead level incr...<br/><br/>L Awad, G Huel, P Lazar, C Boudene (1981) <i>Rev Epidemiol Sante Publique</i> <i></i> <i></i> 29: 2 113-124<br/>

http://publicationslist.org/guy.huel/refid54 2010-02-24T15:06:51Z

Head hair samples were taken from 110 mothers and their newborns at delivery and analyzed for cadmium and lead content. Positive association for cadmium content, but not lead, was found between mothers and newborns. Correlation between the two metals was observed in the babies' hair. Lead levels in the mothers' hair were higher in mothers of parity three or greater than in primiparous mothers. Inv...<br/><br/>G Huel, C Boudene, M A Ibrahim (1981) <i>Arch Environ Health</i> <i></i> <i></i> 36: 5 221-227<br/>

http://publicationslist.org/guy.huel/refid57 2010-02-24T15:06:51Z

In Alsace (France) drinking water is supplied from two different sources. This situation is favourable to study the effects on human health of various water characteristics, among which hardness. However it would be misleading to consider the 947 towns or villages as independent units of observation because of their geographical adjacencies. An aggregation algorithm of these units has been set up....<br/><br/>G Huel, R Thomazeau, F Derriennic, P Lazar (1978) <i>Rev Epidemiol Sante Publique</i> <i></i> <i></i> 26: 5 381-390<br/>

http://publicationslist.org/guy.huel/refid56 2010-02-24T15:06:51Z

The existence of a significant negative correlation between hardness of drinking water and mortality rates from cardiovascular disease has been established by numerous authors. The intensity of this relationship varies according to the country concerned, the size of the areas studied, and the confounding factors taken into consideration. Nevertheless, the problem concerning the interpretation of t...<br/><br/>G Huel, F Derriennic, P Ducimetière, P Lazar (1978) <i>Rev Epidemiol Sante Publique</i> <i></i> <i></i> 26: 4 349-359<br/>

http://publicationslist.org/guy.huel/refid58 2010-02-24T15:06:51Z

A prospective survey was carried out by the French National Institute of Health and Medical Research (INSERM) in 12 University hospitals in Paris and included 12,764 women; 189 gave birth to babies with unequivocal, non-chromosomally based, malformations. There was a significant excess of malformed infants when women had taken phenothiazines during the first three months after the last menstrual p...<br/><br/>C Rumeau-Rouquette, J Goujard, G Huel (1977) <i>Teratology</i> <i></i> <i></i> 15: 1 57-64<br/>

http://publicationslist.org/guy.huel/refid59 2010-02-24T15:06:51Z

C Rumeau-Rouquette, J Goujard, G Huel (1976) <i>Arch Fr Pediatr</i> <i></i> <i></i> 33: 1 5-10<br/>

http://publicationslist.org/guy.huel/refid60 2010-02-24T15:06:51Z

D L Crombie, R J Pinsent, D M Fleming, C Rumeau-Rouquette, J Goujard, G Huel (1975) <i>N Engl J Med</i> <i></i> <i></i> 293: 4 198-199<br/>

http://publicationslist.org/guy.huel/refid61 2010-02-24T15:06:51Z

J Goujard, G Huel, C Rumeau-Rouquette (1974) <i>J Gynecol Obstet Biol Reprod (Paris)</i> <i></i> <i></i> 3: 6 831-842<br/>