http://publicationslist.org/data/h.galski/atom.xml Hanan Galskihttp://publicationslist.org/h.galski$basepathfavicon.icoRecent additions to Hanan Galski's PublicationsList.org pagehttp://publicationslist.org/publications.png2008-10-15T17:44:05Z http://publicationslist.org/h.galski/refid1 2007-07-17T15:43:26Z

Heparanase, endo-beta-D-glucuronidase, degrades heparan sulfate glycosaminoglycans - the principal polysaccharide of the basement membrane and extracellular matrix. Heparanase activity plays a decisive role in biological processes associated with remodeling of the extracellular matrix, such as cancer metastasis, angiogenesis and inflammation. In the hematopoietic system, heparanase is thought to b...<br/><br/> O Ostrovsky, M Korostishevsky, I Levite, M Leiba, H Galski, I Vlodavsky, A Nagler (2007) <i>Leukemia</i> : <br/>

http://publicationslist.org/h.galski/refid23 2007-07-17T15:41:02Z

The aim of the study was to isolate and characterize a population of neuronal progenitors in the human umbilical cord blood (HUCB) mononuclear cell (MNC) fraction, for in vitro manipulation towards neuronal differentiation. Selection of the HUCB neuronal progenitors (HUCBNPs) was based on the neuronal prerequisite for adherence to collagen. Populations of collagen-adherent, nestin-positive (94.8Â...<br/><br/>H Arien-Zakay, A Nagler, H Galski, P Lazarovici (2007) <i>J Mol Neurosci</i> 32: 3 179-191<br/>

http://publicationslist.org/h.galski/refid2 2007-07-17T14:53:13Z

Heparanase is a mammalian endoglucuronidase responsible for heparan sulfate (HS) degradation. HS is a major constituent of the extracellular matrix (ECM) and HS-degrading activity plays a decisive role in fundamental biological processes associated with remodeling of the ECM, such as cancer metastasis, angiogenesis and inflammation. There is great interest in the prospect of genome-wide associatio...<br/><br/>Olga Ostrovsky, Michael Korostishevsky, Iris Levite, Merav Leiba, Hanan Galski, Ephraim Gazit, Israel Vlodavsky, Arnon Nagler (2007) <i>Acta Haematol</i> <i></i> <i></i> 117: 1 57-64<br/>

http://publicationslist.org/h.galski/refid3 2007-07-17T14:53:13Z

Multidrug resistance (MDR) due to over-expression of the MDR1 (ABCB1) gene and its P-glycoprotein (Pgp) product is an obstacle in the treatment of hematological malignancies. In this study, we have evaluated the potency of KT-5720 to reverse Pgp-dependent MDR in vitro and in vivo. KT-5720 (but not its close derivatives, K252a and K252b) reversed multidrug resistance of LM1/MDR cell line at non-tox...<br/><br/>Hanan Galski, Hamutal Sivan, Philip Lazarovici, Arnon Nagler (2006) <i>Leuk Res</i> <i></i> <i></i> 30: 9 1151-1158<br/>

http://publicationslist.org/h.galski/refid4 2007-07-17T14:53:13Z

The use of adult stem cells for myocardial tissue repair might be limited in elderly and sick people because their cells are depleted and exhausted. The present study was conducted to explore the potential of human umbilical cord blood (UCB) CD133+ progenitor cells for myocardial tissue repair in a model of extensive myocardial infarction (MI). CD133+ progenitor cells were isolated from newborn UC...<br/><br/>Jonathan Leor, Esther Guetta, Micha S Feinberg, Hanan Galski, Iris Bar, Radka Holbova, Liron Miller, Parvin Zarin, David Castel, Israel M Barbash, Arnon Nagler (2006) <i>Stem Cells</i> <i></i> <i></i> 24: 3 772-780<br/>

http://publicationslist.org/h.galski/refid5 2007-07-17T14:53:13Z

Multidrug resistance (MDR) due to the expression of the MDR1 gene and its P-glycoprotein (Pgp) product is a major factor in the prognosis and clinical outcome of patients with refractory lymphomas and other malignancies. The aim of our study was to establish a lymphoma, cellular system where a de novo acquisition of multidrug resistance is specifically related to overexpression of a transgenic, hu...<br/><br/>Sarah Findling-Kagan, Hamutal Sivan, Olga Ostrovsky, Arnon Nagler, Hanan Galski (2005) <i>Leuk Res</i> <i></i> <i></i> 29: 4 407-414<br/>

http://publicationslist.org/h.galski/refid6 2007-07-17T14:53:13Z

The human multidrug-resistant gene (MDR1) encodes for P-glycoprotein (P-gp), which is a membrane-bound efflux-transporter conferring resistance to a number of natural cytotoxic drugs and potentially toxic xenobiotics. The wobble C3435T polymorphism at exon 26 was associated with different expression levels of the MDR1 gene and substrate uptake. Differences in allele frequencies of the C3435T polym...<br/><br/>Olga Ostrovsky, Arnon Nagler, Michael Korostishevsky, Ephraim Gazit, Hanan Galski (2004) <i>Ther Drug Monit</i> <i></i> <i></i> 26: 6 679-684<br/>

http://publicationslist.org/h.galski/refid22 2007-07-17T15:27:43Z

P Lazarovici, H Galski, Y Matsuda, J Hochman (1997) <i>J Nat Tox </i> 6: 19-33<br/>

http://publicationslist.org/h.galski/refid7 2007-07-17T14:53:13Z

T-25-Adh cells, cell variants derived from S49 mouse lymphoma, were transduced with a retrovirus containing the human MDR1 cDNA. The resultant cells (HU-1) are cross-resistant to colchicine, doxorubicin, vinblastine and actinomycin D, and their resistance to colchicine is reversed by verapamil. HU-1 cells were used to screen several protein kinase modulators for their ability to reverse multidrug ...<br/><br/>H Galski, P Lazarovici, M M Gottesman, C Murakata, Y Matsuda, J Hochman (1995) <i>Eur J Cancer</i> <i></i> <i></i> 31A: 3 380-388<br/>

http://publicationslist.org/h.galski/refid8 2007-07-17T14:53:13Z

Many human cancers that are initially responsive to chemotherapy eventually fail to respond to treatment. For some drugs, dose escalation that may be required for a cure cannot be achieved because sensitive tissues such as bone marrow (BM) limit cytotoxic therapy. Approaches to prevent or circumvent BM toxicity are therefore a high priority of research on dose escalation protocols. In this study, ...<br/><br/>G H Mickisch, I Aksentijevich, P V Schoenlein, L J Goldstein, H Galski, C Stahle, D H Sachs, I Pastan, M M Gottesman (1992) <i>Blood</i> <i></i> <i></i> 79: 4 1087-1093<br/>

http://publicationslist.org/h.galski/refid9 2007-07-17T14:53:13Z

The development of preclinical models for the rapid testing of agents that circumvent multidrug resistance in cancer is a high priority of research on drug resistance. A common form of multidrug resistance in human cancer results from expression of the MDR1 gene, which encodes a Mr 170,000 glycoprotein that functions as a plasma membrane energy-dependent multidrug efflux pump. We have engineered t...<br/><br/>G H Mickisch, G T Merlino, H Galski, M M Gottesman, I Pastan (1991) <i>Proc Natl Acad Sci U S A</i> <i></i> <i></i> 88: 2 547-551<br/>

http://publicationslist.org/h.galski/refid21 2007-07-17T15:24:16Z

G H Mickisch, G T Merlino, H Galski, M M Gottesman, I Pastan (1991) <i>Aktuel Urol </i> 22: 85-91<br/>

http://publicationslist.org/h.galski/refid10 2007-07-17T14:53:13Z

H Galski, G T Merlino, M M Gottesman, I Pastan (1991) <i>Biotechnology</i> <i></i> <i></i> 16: 103-124<br/>

http://publicationslist.org/h.galski/refid12 2007-07-17T14:54:18Z

Many cancers have been cured by chemotherapeutic agents. However, other cancers are intrinsically drug resistant, and some acquire resistance following chemotherapy. Cloning of the cDNA for the human MDR1 gene (also known as PGY1), which encodes the multidrug efflux protein P-glycoprotein, has made it possible to measure levels of MDR1 RNA in human cancers. We report the levels of MDR1 RNA in grea...<br/><br/>L J Goldstein, H Galski, A Fojo, M Willingham, S L Lai, A Gazdar, R Pirker, A Green, W Crist, G M Brodeur (1989) <i>J Natl Cancer Inst</i> <i></i> <i></i> 81: 2 116-124<br/>

http://publicationslist.org/h.galski/refid11 2007-07-17T14:54:18Z

The human multidrug resistance gene (MDR1) encodes a drug efflux pump glycoprotein (P-glycoprotein) responsible for resistance to multiple cytotoxic drugs. A plasmid carrying a human MDR1 cDNA under the control of a chicken beta-actin promoter was used to generate transgenic mice in which the transgene was mainly expressed in bone marrow and spleen. Immunofluorescence localization studies showed t...<br/><br/>H Galski, M Sullivan, M C Willingham, K V Chin, M M Gottesman, I Pastan, G T Merlino (1989) <i>Mol Cell Biol</i> <i></i> <i></i> 9: 10 4357-4363<br/>

http://publicationslist.org/h.galski/refid13 2007-07-17T14:54:18Z

Free mRNPs isolated from human term placental tissue were examined for protein kinase and phosphoprotein-phosphatase activities. Free mRNPs incubated with [gamma-32P]ATP in a protein kinase standard buffer show self-phosphorylation in the absence of exogenous substrates. Treatment of phosphorylated products with alkali showed a significant phosphorylation of tyrosine residues within the mRNP-prote...<br/><br/>H Lorberboum, H Galski, C Scharf, D Weinstein, N de Groot, A A Hochberg (1986) <i>Mol Biol Rep</i> <i></i> <i></i> 11: 1 29-35<br/>

http://publicationslist.org/h.galski/refid14 2007-07-17T14:54:18Z

The [32P]phosphoamino acids in proteins of first-trimester and term-cultured human placentas have been separated and their relative amounts have been measured. Significant phosphorylation of tyrosine residues could be detected in the cultured placental tissue at different stages of gestation. The phosphotyrosine accounts for 2-4% of the total acid-stable phosphate in the phosphoamino acids after p...<br/><br/>H Galski, N De Groot, J Ilan, A A Hochberg (1984) <i>Biochim Biophys Acta</i> <i></i> <i></i> 804: 1 125-131<br/>

http://publicationslist.org/h.galski/refid15 2007-07-17T14:54:18Z

The [32P]phosphoamino acids in proteins of first trimester and term-cultured human placentas have been separated and their relative amounts were measured. A significant phosphorylation of tyrosine residues could be detected in the cultured placental tissue at different stages of gestation. The phosphotyrosine accounts for 2-4% of the total acid-stable phosphate in the phosphoamino acids after part...<br/><br/>H Galski, N De Groot, J Ilan, A A Hochberg (1983) <i>Biochim Biophys Acta</i> <i></i> <i></i> 761: 3 284-290<br/>

http://publicationslist.org/h.galski/refid20 2007-07-17T15:17:49Z

H Galski, D Weinstein, O Gileadi , H Lorberboum, N de Groot, R Folman, AA Hochberg (1982) <i>Biochem Internatl </i> 5: 137-143<br/>

http://publicationslist.org/h.galski/refid18 2007-07-17T14:54:18Z

The in vitro synthesis of RNA in the human placental tissue, incubated in organ culture, was investigated. We followed the synthesis of the poly A(-) and poly A(+) RNA fractions, and investigated the distribution of the newly synthesized RNA among the subcellular fractions isolated from first and third trimester placentas. The poly A(-) RNA was the major fraction of the RNA synthesized in vitro. T...<br/><br/>H Lorberboum, D Weinstein, H Galski, N de Groot, S Segal, J Ilan, R Folman, A A Hochberg (1982) <i>Mol Biol Rep</i> <i></i> <i></i> 8: 2 103-110<br/>

http://publicationslist.org/h.galski/refid16 2007-07-17T14:54:18Z

We studied the in vitro synthesis and secretion of alkaline phosphatase by human first trimester decidual tissue incubated in organ culture. Decidua synthesizes two different alkaline phosphatase isoenzymes; heat stable and heat labile. decidual tissue maintains a constant pool of alkaline phosphatases. The synthesis of alkaline phosphatase may be the driving force for its secretion. The de novo s...<br/><br/>H Galski, D Weinstein, K Abraham, N de Groot, S Segal, R Folman, A A Hochberg (1982) <i>Eur J Obstet Gynecol Reprod Biol</i> <i></i> <i></i> 14: 1 1-11<br/>

http://publicationslist.org/h.galski/refid17 2007-07-17T14:54:18Z

We studied the in vitro synthesis and secretion of hPL by human term placental tissue incubated in organ culture. Placental tissue maintains a constant pool of hPL. The synthesis of hPL may be the driving force for its secretion. The de novo synthesis and secretion rates of hPL were also investigated. The higher specific radioactivities of the secreted hPL than those found in the tissue may sugges...<br/><br/>D Weinstein, H Galski, J G Schenker, H Lorberboum, N de Groot, J Ilan, R Folman, A A Hochberg (1982) <i>Mol Cell Endocrinol</i> <i></i> <i></i> 26: 1-2 189-199<br/>

http://publicationslist.org/h.galski/refid19 2007-07-17T14:54:18Z

The synthesis and secretion of alkaline phosphatases in vitro by human placental tissue incubated in organ culture were studied. First-trimester placenta synthesizes and secretes two different alkaline phosphatase isoenzymes (heat-labile and heat-stable), whereas in term placenta nearly all the alkaline phosphatase synthesized and secreted is heat-stable. The specific activities of alkaline phosph...<br/><br/>H Galski, S E Fridovich, D Weinstein, N De Groot, S Segal, R Folman, A A Hochberg (1981) <i>Biochem J</i> <i></i> <i></i> 194: 3 857-866<br/>