http://publicationslist.org/data/hidekazu.suzuki/atom.xml Hidekazu Suzukihttp://publicationslist.org/hidekazu.suzuki$basepathfavicon.icoRecent additions to Hidekazu Suzuki's PublicationsList.org pagehttp://publicationslist.org/publications.png2009-02-27T11:36:36Z http://publicationslist.org/hidekazu.suzuki/refid130 2009-02-27T11:22:58Z

MicroRNAs (miRNAs) are small noncoding RNAs that function as endogenous silencers of numerous target genes. Hundreds of human miRNAs have been identified in the human genome, and they are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Links between miRNAs and human diseases are increasingly apparent, and aberrant expression of ...<br/><br/>Yoshimasa Saito, Hidekazu Suzuki, Toshifumi Hibi (2009) <i>J Gastroenterol</i> <i></i> <i></i> 44 Suppl 19: 18-22<br/>

http://publicationslist.org/hidekazu.suzuki/refid134 2009-02-27T11:29:08Z

Background: Recently, the number of Helicobacter pylori isolates showing antibiotic resistance has been increasing. Rifabutin (RFB) is one of the possible candidates for H. pylori eradication. In the present study, the RFB minimum inhibitory concentrations (MICs) and the resistance-determining genes to RFB (rpoB) were examined to clarify the relationship between drug MICs, rpoB mutations, and past...<br/><br/>Shoji Suzuki, Hidekazu Suzuki, Toshihiro Nishizawa, Fumihiko Kaneko, Sumire Ootani, Hiroe Muraoka, Yoshimasa Saito, Intetsu Kobayashi, Toshifumi Hibi (2009) <i>Digestion</i> 79: 1 1-4<br/>

http://publicationslist.org/hidekazu.suzuki/refid131 2009-02-27T11:29:47Z

Resistance of H. pylori has been demonstrated to the standard therapeutic antimicrobials (clarithromycin (CLR), metronidazole, amoxicillin (AMX) and tetracycline) [1], therefore, other treatment options must be urgently introduced. ...<br/><br/> Hidekazu Suzuki, Toshihiro Nishizawa, Hiroe Muraoka, Toshifumi Hibi (2009) <i>Antimicrob Agents Chemother</i> : <br/>

http://publicationslist.org/hidekazu.suzuki/refid136 2009-02-27T11:31:13Z

VATER association represents a cluster of Vertebral, Anal, Tracheo-Esophageal, Radial and Renal malformations and caudal regression syndrome is an entity consisting of a spectrum of congenital anomalies of lower spine and hips associated with genitourinary and lower limb defects. The concurrence of various malformations may be explained by a common defect in blastogenesis, but direct evidence is y...<br/><br/>Yoko Naito, Tokuhiro Kimura, Michihiko Aramaki, Kosuke Izumi, Yasunori Okada, Hidekazu Suzuki, Takao Takahashi, Kenjiro Kosaki (2009) <i>Pediatr Res</i> : <br/>

http://publicationslist.org/hidekazu.suzuki/refid129 2008-07-16T03:38:21Z

Proton pump inhibitors (PPIs) are novel compounds that strongly inhibit the H(+)/K(+)-ATPase in the gastric parietal cells to cause profound suppression of acid secretion. Acid-generating ATPase, also known as vacuolar-type ATPase, is located in the lysozomes of leukocytes and osteoclasts and its activity is also reportedly influenced by treatment with PPIs. This concept is supported by the result...<br/><br/>Masayuki Suzuki, Hidekazu Suzuki, Toshifumi Hibi (2008) <i>J Clin Biochem Nutr</i> <i></i> <i></i> 42: 2 71-75<br/>

http://publicationslist.org/hidekazu.suzuki/refid141 2009-02-27T11:32:04Z

BACKGROUND/AIMS: Polyarteritis nodosa (PN) has been classified into polyarteritis (PA) and microscopic polyarteritis (MA) histologically. To clarify of the characteristics of upper gastrointestinal bleeding lesions in PN, we investigated the patients of PN with rapidly progressive glomerulonephritis (RPGN) presenting with upper gastrointestinal bleeding. METHODOLOGY: The subjects of this study wer...<br/><br/>Tadashi Ohara, Yuhsaku Kanoh, Yoshio Taguma, Hiroshi Hashimoto, Hidekazu Suzuki, Yuji Sakai, Fukuo Kondo, Jin-ichi Kameyama, Norio Tani, Keiichi Yoshino, Masaki Kitajima (2008) <i>Hepatogastroenterology</i> 55: 84 821-825<br/>

http://publicationslist.org/hidekazu.suzuki/refid127 2008-07-16T03:38:21Z

Proton pump inhibitors (PPIs) are now commonly used for the treatment of acid related diseases such as peptic ulcer and reflux esophagitis. Because of their ability to produce direct inhibition of the proton pump, PPIs provide more sustained increase of the gastric pH than H(2)-receptor (H(2)R) antagonists. Diverse reports have been published on gastric epithelial cell modality associated with PPI...<br/><br/>Tatsuhiro Masaoka, Hidekazu Suzuki, Toshifumi Hibi (2008) <i>J Clin Biochem Nutr</i> <i></i> <i></i> 42: 3 191-196<br/>

http://publicationslist.org/hidekazu.suzuki/refid128 2009-02-27T11:22:58Z

BACKGROUND/AIMS: To examine the influence of long-term treatment of H. pylori-infected patients with proton pump inhibitors (PPI) on the toxic oxidant production in the stomach. METHODOLOGY: Eight H. pylori-positive patients with gastric ulcer were enrolled, and tissue samples were obtained endoscopically from the antrum and corpus. The tissue contents of neutrophil myeloperoxidase (MPO) and oxyge...<br/><br/>Masayuki Suzuki, Shin Tanaka, Koichi Suzuki, Tetsuji Kitahora, Tatsuhiro Masaoka, Hidekazu Suzuki, Toshifumi Hibi (2008) <i>Hepatogastroenterology</i> <i></i> <i></i> 55: 81 138-141<br/>

http://publicationslist.org/hidekazu.suzuki/refid132 2009-02-27T11:22:58Z

BACKGROUND: Body mass index (BMI) and obesity are reportedly associated with symptoms of gastroesophageal reflux disease (GERD). The present study was designed to investigate the effect of metabolic disorders including obesity on the levels of functional gastroesophageal reflux by videoesophagography. METHODS: Twenty-one patients with GERD-associated symptoms were examined by videoesophagography. ...<br/><br/>Eisuke Iwasaki, Hidekazu Suzuki, Yoshinori Sugino, Tsutomu Iida, Toshihiro Nishizawa, Tatsuhiro Masaoka, Hiroshi Hosoda, Kenji Kangawa, Toshifumi Hibi (2008) <i>J Gastroenterol Hepatol</i> <i></i> <i></i> 23 Suppl 2: S216-S221<br/>

http://publicationslist.org/hidekazu.suzuki/refid133 2009-02-27T11:22:58Z

BACKGROUND AND AIM: This study was designed to investigate the efficacy of gatifloxacin (GAT)-based triple therapy as a third-line treatment for Helicobacter pylori (H. pylori) eradication, according to the assessment of the susceptibility to GAT and gyrA mutation. METHODS: Fourteen patients who had eradication failure following both clarithromycin-based triple therapy and metronidazole-based trip...<br/><br/>Toshihiro Nishizawa, Hidekazu Suzuki, Izumi Nakagawa, Eisuke Iwasaki, Tatsuhiro Masaoka, Toshifumi Hibi (2008) <i>J Gastroenterol Hepatol</i> <i></i> <i></i> 23 Suppl 2: S167-S170<br/>

http://publicationslist.org/hidekazu.suzuki/refid139 2009-02-27T11:24:44Z

Immune thrombocytopenia purpura (ITP) is a bleeding disorder in which platelet-specific autoantibodies cause a loss of platelets. In a subset of patients with ITP and infected with Helicobacter pylori, the number of platelets recovers after eradication of H. pylori. To examine the role of H. pylori infection in the pathogenesis of ITP, the response of 34 ITP patients to treatment with a standard H...<br/><br/>Atsuko Asahi, Tetsuya Nishimoto, Yuka Okazaki, Hidekazu Suzuki, Tatsuhiro Masaoka, Yutaka Kawakami, Yasuo Ikeda, Masataka Kuwana (2008) <i>J Clin Invest</i> 118: 8 2939-2949<br/>

http://publicationslist.org/hidekazu.suzuki/refid135 2009-02-27T11:22:58Z

In the Krebs cycle of Helicobacter pylori, the absence of alpha-ketoglutarate dehydrogenase and succinyl CoA synthetase are shown. Instead, alpha-ketoglutarate is converted to succinyl CoA and succinate by alpha-ketoglutarate oxidoreductase (KOR) and CoA transferase (CoAT). In the present study, when H. pylori transformed to the coccoid form, a viable but non-culturable form of H. pylori with redu...<br/><br/>Hitoshi Tsugawa, Hidekazu Suzuki, Izumi Nakagawa, Toshihiro Nishizawa, Yoshimasa Saito, Makoto Suematsu, Toshifumi Hibi (2008) <i>Biochem Biophys Res Commun</i> <i></i> <i></i> 376: 1 46-51<br/>

http://publicationslist.org/hidekazu.suzuki/refid5 2008-03-19T10:58:56Z

BACKGROUND AND AIM: Several scoring systems have been devised to identify patients with upper gastrointestinal (UGI) bleeding who are at a high risk of adverse outcomes. We retrospectively evaluated the accuracy of the Blatchford scoring system for assessing the need for clinical intervention in cases of UGI bleeding admitted to the emergency department (ED). METHODS: This was a retrospective stud...<br/><br/>Tatsuhiro Masaoka, Hidekazu Suzuki, Shingo Hori, Naoki Aikawa, Toshifumi Hibi (2007) <i>J Gastroenterol Hepatol</i> <i></i> <i></i> 22: 9 1404-1408<br/>

http://publicationslist.org/hidekazu.suzuki/refid112 2008-03-19T11:39:25Z

The important human gastric pathogen Helicobacter pylori is the subject of many studies, and as a consequence it is frequently being transported between national and international laboratories. Unfortunately, common bacterial growth and transport media contain serum- and animal tissue-derived materials, which carry the risk of spreading infectious diseases. We have therefore developed a growth and...<br/><br/>Cindy M Dierikx, Jaime Martodihardjo, Ernst J Kuipers, Charles M H Hensgens, Johannes G Kusters, Hidekazu Suzuki, Nanda de Groot, Arnoud H M van Vliet (2007) <i>FEMS Immunol Med Microbiol</i> 50: 2 239-243<br/>

http://publicationslist.org/hidekazu.suzuki/refid6 2008-03-19T10:58:56Z

OBJECTIVE: Harmonic flash echo imaging, which is an intermittent second harmonic imaging technique, has recently been developed for the evaluation of blood flow. The present study was designed to investigate human gastric blood flow during administration of non-steroidal anti-inflammatory drugs (NSAIDs) by harmonic flash echo imaging. MATERIAL AND METHODS: Eight healthy volunteers were enrolled in...<br/><br/>Toshihiro Nishizawa, Hidekazu Suzuki, Tatsuhiro Masaoka, Eisuke Iwasaki, Toshifumi Hibi (2007) <i>Scand J Gastroenterol</i> <i></i> <i></i> 42: 9 1040-1044<br/>

http://publicationslist.org/hidekazu.suzuki/refid10 2008-03-19T10:58:56Z

Helicobacter pylori strains with reduced susceptibility to fluoroquinolones have a mutation at either codon 87 Asn or 91 Asp of the gyrA gene. A rapid test based on an allele-specific PCR (AS-PCR) was designed to detect the gyrA mutations. Clinical H. pylori isolates were obtained from the stomachs of 51 patients with H. pylori infections who showed treatment failure. The MICs of gatifloxacin (GAT...<br/><br/>Toshihiro Nishizawa, Hidekazu Suzuki, Ayako Umezawa, Hiroe Muraoka, Eisuke Iwasaki, Tatsuhiro Masaoka, Intetsu Kobayashi, Toshifumi Hibi (2007) <i>J Clin Microbiol</i> <i></i> <i></i> 45: 2 303-305<br/>

http://publicationslist.org/hidekazu.suzuki/refid9 2008-03-19T10:58:56Z

The discovery of Helicobacter pylori has already changed the natural history of peptic ulcer disease, with most patients being cured at their first presentation. Similarly, the incidence of gastric cancer and other diseases related to H. pylori are likely to be greatly reduced in the near future. Isolation of the spiral intragastric bacterium H. pylori totally reversed the false dogma that the sto...<br/><br/>Hidekazu Suzuki, Toshifumi Hibi, Barry James Marshall (2007) <i>J Gastroenterol</i> <i></i> <i></i> 42: 1 1-15<br/>

http://publicationslist.org/hidekazu.suzuki/refid4 2008-03-19T10:58:56Z

Expression of sonic hedgehog (Shh), a morphogen for the gastric fundic glands, is reduced in the atrophic mucosa that develops in association with Helicobacter pylori infection, resulting in impaired differentiation of the fundic gland cells, increased expression of trefoil factor family 2 (TFF2) and the formation of spasmolytic polypeptide (SP)-expressing metaplasia (SPEM), a preneoplastic lesion...<br/><br/>Y Minegishi, H Suzuki, M Arakawa, Y Fukushima, T Masaoka, T Ishikawa, N A Wright, T Hibi (2007) <i>J Pathol</i> <i></i> <i></i> 213: 2 161-169<br/>

http://publicationslist.org/hidekazu.suzuki/refid7 2008-03-19T10:58:56Z

BACKGROUND/AIMS: Sonic hedgehog (Shh) is a morphogen involved in many aspects of patterning of the gut during embryogenesis and in gastric fundic gland homeostasis in the adult. Shh expression is reportedly to be reduced in Helicobacterpylori-associated gastritis. The aim of this study was to assess the restoration of Shh expression after H. pylori eradication. METHODOLOGY: Twenty H. pylori-positi...<br/><br/>Toshihiro Nishizawa, Hidekazu Suzuki, Tatsuhiro Masaoka, Yuriko Minegishi, Eisuke Iwasahi, Toshifumi Hibi (2007) <i>Hepatogastroenterology</i> <i></i> <i></i> 54: 75 697-700<br/>

http://publicationslist.org/hidekazu.suzuki/refid1 2008-07-16T03:38:21Z

BACKGROUND: It is helpful in clinical practice to predict the effects of eradication therapy on Helicobacter pylori. AIM: To develop a useful predictor of the response to metronidazole (MNZ)-containing second-line regimens by combining minimal inhibitory concentrations (MICs) of both amoxicillin (AMX) and MNZ, and the results of urea breath test (UBT) before the treatment. METHODS: We enrolled 107...<br/><br/>Toshihiro Nishizawa, Hidekazu Suzuki, Tatsuhiro Masaoka, Eisuke Iwasaki, Toshifumi Hibi (2007) <i>Digestion</i> <i></i> <i></i> 76: 3-4 215-220<br/>

http://publicationslist.org/hidekazu.suzuki/refid3 2008-03-19T10:58:56Z

BACKGROUND: Ghrelin, an appetite-promoting peptide secreted from the stomach, is reported to enhance preprandial acid output, possibly through stimulation of the cephalic phase. The present study was designed to clarify the dynamics of ghrelin in H(2) receptor (H(2)R)-null mice by genetic H(2)R knockout. METHODS: Fifteen-week- and 54-week-old H(2)R-null mice and their littermates were used. After ...<br/><br/>Mamoru Arakawa, Hidekazu Suzuki, Yuriko Minegishi, Yasushi Fukushima, Tatsuhiro Masaoka, Takashi Ishikawa, Hiroshi Hosoda, Kenji Kangawa, Toshifumi Hibi (2007) <i>J Gastroenterol</i> <i></i> <i></i> 42: 9 711-718<br/>

http://publicationslist.org/hidekazu.suzuki/refid137 2009-02-27T11:23:50Z

Comparative genomics is a promising approach for identifying regulatory elements governing the unique spatio-temporal expression patterns of morphogenetic genes. Conserved noncoding genomic sequences are candidate regulatory elements. Here we performed a survey for conserved noncoding elements (CNE) nested within the SALL1 gene; mutations in this gene result in the Townes-Brocks syndrome. A compar...<br/><br/>Kosuke Izumi, Michihiko Aramaki, Tokuhiro Kimura, Yoko Naito, Toru Udaka, Masanori Uchikawa, Hisato Kondoh, Hidekazu Suzuki, Ginam Cho, Yasunori Okada, Takao Takahashi, Jeffrey A Golden, Kenjiro Kosaki (2007) <i>Pediatr Res</i> <i></i> <i></i> 61: 6 660-665<br/>

http://publicationslist.org/hidekazu.suzuki/refid140 2009-02-27T11:25:48Z

BACKGROUND: One week of Helicobacter pylori eradication therapy is insufficient for healing of gastric ulcers. We examined the efficacy of rebamipide in gastric ulcer healing following 1 week of eradication therapy in a randomized, double-blind, placebo-controlled trial. METHODS: Patients with H. pylori-positive gastric ulcer were enrolled and received 1 week of eradication therapy, followed by 10...<br/><br/>Akira Terano, Tetsuo Arakawa, Toshiro Sugiyama, Hidekazu Suzuki, Takashi Joh, Toshikazu Yoshikawa, Kazuhide Higuchi, Ken Haruma, Kazunari Murakami, Kenzo Kobayashi (2007) <i>J Gastroenterol</i> 42: 8 690-693<br/>

http://publicationslist.org/hidekazu.suzuki/refid2 2008-03-19T10:58:56Z

T Nishizawa, H Suzuki, T Masaoka, T Hibi (2007) <i>J Gastroenterol Hepatol</i> <i></i> <i></i> 22: 11 <br/>

http://publicationslist.org/hidekazu.suzuki/refid17 2008-03-19T11:03:49Z

The genomic DNA of toll-like receptor (TLR) 2, TLR4, radioprotective 105, TLR6, and TLR9 were examined for mutations in 48 patients with gastric cancer. Of these, 22 had well-differentiated and 20 had poorly-differentiated adenocarcinomas, the latter group including 10 with signet ring cell carcinomas. The remaining 6 had gastric adenomas. Ten healthy volunteers with no family history of malignant...<br/><br/>Tadashi Ohara, Tetsuo Morishita, Hidekazu Suzuki, Toshifumi Hibi (2006) <i>Int J Mol Med</i> <i></i> <i></i> 18: 1 59-63<br/>

http://publicationslist.org/hidekazu.suzuki/refid16 2008-03-19T11:03:49Z

Although placebo response rates in clinical trials for functional dyspepsia (FD) are more than 30%, a recent meta-analysis based on randomized controlled trials (RCTs) showed that antisecretory drugs were more or less superior to placebos. On the other hand, large-scale RCTs on the efficacy of treatment with prokinetics on FD are still needed. Indications for antibiotic eradication therapy for Hel...<br/><br/>Hidekazu Suzuki, Toshihiro Nishizawa, Toshifumi Hibi (2006) <i>J Gastroenterol</i> <i></i> <i></i> 41: 6 513-523<br/>

http://publicationslist.org/hidekazu.suzuki/refid18 2008-03-19T11:03:49Z

BACKGROUND AND STUDY AIMS: Endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) has improved the success rate of en-bloc resection. We report here on a new technique using an external grasping forceps. PATIENTS AND METHODS: A total of 25 patients with suitable EGCs over 10 mm in diameter located in the gastric body were enrolled. After submucosal injection followed by circumcision...<br/><br/>H Imaeda, Y Iwao, H Ogata, H Ichikawa, M Mori, N Hosoe, T Masaoka, M Nakashita, H Suzuki, N Inoue, K Aiura, H Nagata, K Kumai, T Hibi (2006) <i>Endoscopy</i> <i></i> <i></i> 38: 10 1007-1010<br/>

http://publicationslist.org/hidekazu.suzuki/refid19 2008-03-19T11:03:49Z

A high resistance rate (47.9%) to gatifloxacin (GAT; 8-methoxy fluoroquinolone) in Helicobacter pylori (H. pylori) strains from 48 Japanese patients is observed after unsuccessful H. pylori eradication. A significant association between MICs for GAT equal to or above 1 microg/ml and mutations of the gyrA gene of H. pylori was demonstrated.<br/><br/>Toshihiro Nishizawa, Hidekazu Suzuki, Kumiko Kurabayashi, Tatsuhiro Masaoka, Hiroe Muraoka, Mikiji Mori, Eisuke Iwasaki, Intetsu Kobayashi, Toshifumi Hibi (2006) <i>Antimicrob Agents Chemother</i> <i></i> <i></i> 50: 4 1538-1540<br/>

http://publicationslist.org/hidekazu.suzuki/refid21 2008-03-19T11:03:49Z

The possible involvement of Toll-like receptor (TLR) genome DNA in the prolongation and relapse of inflammatory intestinal diseases and alcoholic hepatic diseases has been reported. In this study, we examined the relationship of mutations of the TLR 2, 4, 6 and 9 genomic DNA to recurrent or intractable gastritis or gastric ulcers. The subjects were 32 patients, including 6 with H. pylori (Hp)-posi...<br/><br/>Tadashi Ohara, Tetsuo Morishita, Hiroshi Hashimoto, Masumi Akimoto, Yuhsaku Kanoh, Noriko Nakajima, Hidekazu Suzuki, Toshifumi Hibi (2006) <i>Int J Mol Med</i> <i></i> <i></i> 17: 1 53-58<br/>

http://publicationslist.org/hidekazu.suzuki/refid20 2008-03-19T11:03:49Z

Musashi-1 is involved in maintenance of neural stem cells. In the rat stomach, we found some cells in the luminal compartment of the mucosa that stained positively for Musashi-1. These cells were distinct from other cells of epithelial lineage, except for parietal cells, and coexpressed HES5. The Musashi-1-positive cells exfoliated after damage, while Musashi-1 expression in neck cells were upregu...<br/><br/>Hiroshi Nagata, Yasutada Akiba, Hidekazu Suzuki, Hideyuki Okano, Toshifumi Hibi (2006) <i>FEBS Lett</i> <i></i> <i></i> 580: 1 27-33<br/>

http://publicationslist.org/hidekazu.suzuki/refid15 2008-03-19T11:03:49Z

Ghrelin, a novel gastrointestinal peptide with 28 amino acids, is secreted from the A-like cells of the gastric fundus. This peptide hormone does not only promote the release of growth hormone, but also stimulates food intake, gastric motility and cardiac output. Increased plasma ghrelin level has been reported in patients with upper gastrointestinal (GI) disease or in their disease animal model, ...<br/><br/>Hidekazu Suzuki, Tatsuhiro Masaoka, Toshifumi Hibi (2006) <i>Korean J Gastroenterol</i> <i></i> <i></i> 48: 2 82-88<br/>

http://publicationslist.org/hidekazu.suzuki/refid110 2008-03-19T11:35:41Z

Zinc is an essential nutrient with a wide range of functions and closely involved in a variety of enzymatic processes of importance in glucose, protein and lipid metabolism. Ghrelin is the endogenous ligand of the G protein coupled growth hormone secretagogue receptor. The regulatory mechanism that explain the biosynthesis and secretion of ghrelin in the gastrointestinal tract has not been clarifi...<br/><br/>S Bolkent, R Yanardag, O Mutlu, S Yildirim, K Kangawa, Y Minegishi, H Suzuki (2006) <i>Mol Cell Biochem</i> 286: 1-2 77-85<br/>

http://publicationslist.org/hidekazu.suzuki/refid13 2008-03-19T11:03:49Z

Gene mutations are essential to carcinogenesis. If an evident difference is observed in gastric mucosal chromosomal structure aberrations between H. pylori (Hp)-negative and Hp-positive gastric cancer patients, it may be interpreted as suggesting the involvement of Hp in gene mutations. This study was undertaken to compare chromosomal structural aberrations between Hp-negative and Hp-positive gast...<br/><br/>Tadashi Ohara, Junji Kasanuki, Hisaaki Ohara, Yuhsaku Kanoh, Hidekazu Suzuki, Hiroshi Hashimoto, Toshimi Chiba, Tetsuo Morishita, Toshifumi Hibi (2006) <i>Oncol Rep</i> <i></i> <i></i> 16: 6 1333-1342<br/>

http://publicationslist.org/hidekazu.suzuki/refid11 2008-03-19T11:03:49Z

Isolation of the gastric spiral bacterium Helicobacter pylori totally reversed the false dogma that the stomach was sterile. In addition to its causal role in peptic ulceration, the newly identified bacterium has now been implicated in other gastric and even extragastric diseases, including chronic atrophic gastritis, gastric MALT lymphoma, gastric cancer, functional dyspepsia, idiopathic thromboc...<br/><br/>Hidekazu Suzuki, Barry James Marshall, Toshifumi Hibi (2006) <i>Int J Hematol</i> <i></i> <i></i> 84: 4 291-300<br/>

http://publicationslist.org/hidekazu.suzuki/refid14 2008-03-19T11:03:49Z

Thirty-seven patients with idiopathic thrombocytopenic purpura (ITP) were treated with a standard Helicobacter pylori eradication regimen irrespective of H. pylori infection. Our results indicate that platelet recovery results from the disappearance of H. pylori itself, and is mediated, in part, through suppression of anti-platelet autoantibody production.<br/><br/>Atsuko Asahi, Masataka Kuwana, Hidekazu Suzuki, Toshifumi Hibi, Yutaka Kawakami, Yasuo Ikeda (2006) <i>Haematologica</i> <i></i> <i></i> 91: 10 1436-1437<br/>

http://publicationslist.org/hidekazu.suzuki/refid114 2008-03-19T11:44:00Z

BACKGROUND: With the increase in the frequency of clarithromycin-resistant Helicobacter pylori (H. pylori), there is rising concern about the decline of the eradication rate of this infection following treatment. The Tokyo Hp Study Group examined the eradication rate in response to a second-line regimen consisting of proton pump inhibitor (PPI), amoxicillin, and metronidazole by conducting a multi...<br/><br/>Takeshi Matsuhisa, Takashi Kawai, Tatsuhiro Masaoka, Hidekazu Suzuki, Masayoshi Ito, Yo Kawamura, Kengo Tokunaga, Masayuki Suzuki, Tetsuya Mine, Shin-ichi Takahashi, Nobuhiro Sakaki (2006) <i>Helicobacter</i> 11: 3 152-158<br/>

http://publicationslist.org/hidekazu.suzuki/refid113 2008-03-19T11:42:50Z

Helicobacter pylori is associated with gastric disorders in humans and some experimental animals, and possesses the luxS/type 2 autoinducer (AI-2) system. The effects of a specific luxS mutation on the characteristics of H. pylori were examined. On 0.3 % agar medium, motility of H. pylori HPKY08 (luxS : : cat) was significantly lower than that of wild-type H. pylori TK1402. The luxS-complemented s...<br/><br/>Takako Osaki, Tomoko Hanawa, Taki Manzoku, Minoru Fukuda, Hayato Kawakami, Hidekazu Suzuki, Hiroyuki Yamaguchi, Xu Yan, Haruhiko Taguchi, Satoshi Kurata, Shigeru Kamiya (2006) <i>J Med Microbiol</i> 55: Pt 11 1477-1485<br/>

http://publicationslist.org/hidekazu.suzuki/refid28 2008-03-19T11:03:49Z

We report on a case of chronic atrophic gastritis in which the serological markers of gastric diseases were strictly monitored for 2 years after successful Helicobacter pylori (H. pylori) eradication. A 31-year-old man with upper abdominal pain was diagnosed as having H. pylori infection. Laboratory examination revealed low serum levels of pepsinogen (PG) I, low PG I/II ratio, and low plasma level...<br/><br/>Tatsuhiro Masaoka, Hidekazu Suzuki, Hiroyuki Imaeda, Hiroshi Hosoda, Tadashi Ohara, Tetsuo Morishita, Hiromasa Ishii, Kenji Kangawa, Toshifumi Hibi (2005) <i>Hepatogastroenterology</i> <i></i> <i></i> 52: 61 1-4<br/>

http://publicationslist.org/hidekazu.suzuki/refid29 2008-03-19T11:03:49Z

Ghrelin, produced and secreted by the A-like cells of the stomach, stimulates growth hormone secretion, gastric motility, and food intake. Cysteamine inhibits the release of somatostatin and induces the formation of duodenal ulcers in rats. The present study was conducted to investigate the dynamics of ghrelin secretion in rats treated with cysteamine. Male Wistar rats (7 wk old) were administered...<br/><br/>Seiichiro Fukuhara, Hidekazu Suzuki, Tatsuhiro Masaoka, Mamoru Arakawa, Hiroshi Hosoda, Yuriko Minegishi, Kenji Kangawa, Hiromasa Ishii, Masaki Kitajima, Toshifumi Hibi (2005) <i>Am J Physiol Gastrointest Liver Physiol</i> <i></i> <i></i> 289: 1 G138-G145<br/>

http://publicationslist.org/hidekazu.suzuki/refid27 2008-03-19T11:03:49Z

Sonic hedgehog (Shh) is a morphogen involved in many aspects of patterning of the gut during embryogenesis and in gastric fundic gland homeostasis in the adult. Intestinal metaplastic change of the gastric epithelium is associated with the loss of Shh expression, and mice that lack Shh expression show intestinal transformation of the gastric mucosa. The present study was designed to investigate th...<br/><br/>Hidekazu Suzuki, Yuriko Minegishi, Yohei Nomoto, Takayuki Ota, Tatsuhiro Masaoka, Gijs R van den Brink, Toshifumi Hibi (2005) <i>J Pathol</i> <i></i> <i></i> 206: 2 186-197<br/>

http://publicationslist.org/hidekazu.suzuki/refid32 2008-03-19T11:03:49Z

BACKGROUND AND AIM: Helicobacter pylori is known to be a major pathogenic factor in the development of gastritis, peptic ulcer disease and gastric cancer. Recently, chicken egg yolk immunoglobulin Y (IgY) has been recognized as an inexpensive antibody source for passive immunization against gastrointestinal infections. The present study was designed to investigate the effect of anti-urease IgY on ...<br/><br/>Sachiko Nomura, Hidekazu Suzuki, Tatsuhiro Masaoka, Kumiko Kurabayashi, Hiromasa Ishii, Masaki Kitajima, Kikuo Nomoto, Toshifumi Hibi (2005) <i>Helicobacter</i> <i></i> <i></i> 10: 1 43-52<br/>

http://publicationslist.org/hidekazu.suzuki/refid26 2008-03-19T11:03:49Z

Alcohol dehydrogenase (ADH) participates in the formation of retinoic acid from retinol in various organs including the gastric mucosa. However, its clinical significance still remains to be clarified. In this study, we identified the ADH isoforms responsible for the retinoic acid formation among various ADH isoforms and examined associations among the ADH activities, the retinoic acid formation l...<br/><br/>Michinaga Matsumoto, Hirokazu Yokoyama, Hidekazu Suzuki, Haruko Shiraishi-Yokoyama, Toshifumi Hibi (2005) <i>Am J Physiol Gastrointest Liver Physiol</i> <i></i> <i></i> 289: 3 G429-G433<br/>

http://publicationslist.org/hidekazu.suzuki/refid31 2008-03-19T11:03:49Z

The proton pump inhibitors (PPIs) are a relatively new class of agents used for the treatment of acid-related disorders, including peptic ulcer diseases, reflux oesophagitis and Zollinger-Ellison syndrome, and in enhancing antibiotic therapy in the eradication of Helicobacter pylori in patients with peptic ulcer disease. The PPIs are the most potent gastric acid-suppressing agents currently in cli...<br/><br/>Hidekazu Suzuki, Toshifumi Hibi (2005) <i>Expert Opin Pharmacother</i> <i></i> <i></i> 6: 1 59-67<br/>

http://publicationslist.org/hidekazu.suzuki/refid24 2008-03-19T11:03:49Z

AIM: Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor, and it plays a role in stimulating the growth hormone secretion, food intake, body weight gain and gastric motility. Eradication of Helicobacter pylori (H pylori) was shown to be associated with increase of the body weight. On the other hand, H pylori infection evokes the release of gastric IL-1beta. The present stu...<br/><br/>Yuka Abiko, Hidekazu Suzuki, Tatsuhiro Masaoka, Sachiko Nomura, Kumiko Kurabayashi, Hiroshi Hosoda, Kenji Kangawa, Toshifumi Hibi (2005) <i>World J Gastroenterol</i> <i></i> <i></i> 11: 27 4148-4153<br/>

http://publicationslist.org/hidekazu.suzuki/refid22 2008-03-19T11:03:49Z

Functional dyspepsia (FD) refers to a broad range of chronic upper abdominal symptoms associated with food intake. A definitive treatment for FD has not yet been established, and the effect of Helicobacter pylori (H. pylori) eradication still remains under debate. The Gastrointestinal Symptom Rating Scale (GSRS) is a specific questionnaire for patients with gastrointestinal symptoms. The present s...<br/><br/>Hidekazu Suzuki, Tatsuhiro Masaoka, Gen Sakai, Hiromasa Ishii, Toshifumi Hibi (2005) <i>J Gastroenterol Hepatol</i> <i></i> <i></i> 20: 11 1652-1660<br/>

http://publicationslist.org/hidekazu.suzuki/refid23 2008-03-19T11:03:49Z

BACKGROUND/AIMS: It has previously been reported that human-beta defensin 2 (hBD2) has a physiological role as a proinflammatory mediator in gastric mucosal inflammation as well as an antimicrobial peptide for Helicobacter pylori (Hp). The present study was conducted to evaluate the possibility of hBD2 as a molecular marker of gastric mucosal inflammation. METHODOLOGY: The subjects were 40 A1 to S...<br/><br/>Tadashi Ohara, Tetsuo Morishita, Hidekazu Suzuki, Tatsuhiro Masaoka, Toshihiro Nishizawa, Toshifumi Hibi (2005) <i>Hepatogastroenterology</i> <i></i> <i></i> 52: 65 1320-1324<br/>

http://publicationslist.org/hidekazu.suzuki/refid25 2008-03-19T11:03:49Z

Hidekazu Suzuki, Toshifumi Hibi (2005) <i>J Gastroenterol</i> <i></i> <i></i> 40: 4 437-439<br/>

http://publicationslist.org/hidekazu.suzuki/refid45 2008-03-19T11:16:42Z

BACKGROUND/AIMS: Gastric mucosa of patients with chronic renal failure on regular hemodialysis is known to retain fundic glands relatively intact, but no evidence for regeneration of fundic glands by hemodialysis has been provided to date. This study was performed to investigate endoscopically and histopathologically if hemodialysis to treat renal failure would regenerate the background gastric mu...<br/><br/>Tadashi Ohara, Hidekazu Suzuki, Yuhsaku Kanoh, Rika Moriya, Isao Okayasu, Tetsuo Morishita, Hiromasa Ishii (2004) <i>Hepatogastroenterology</i> <i></i> <i></i> 51: 57 679-683<br/>

http://publicationslist.org/hidekazu.suzuki/refid44 2008-03-19T11:16:42Z

BACKGROUND: The gastric mucosal alcohol dehydrogenase activity was reported to be reduced in subjects with Helicobacter pylori-associated chronic gastritis. However, the role of H. pylori infection in the metabolism of ingested ethanol has not been fully elucidated. AIM: To clarify whether H. pylori infection exerts any influence on the metabolism of small amounts of ethanol in humans. SUBJECTS AN...<br/><br/>M Suzuki, K Maruyama, H Suzuki, S Tanaki, K Suzuki, H Ishii (2004) <i>Aliment Pharmacol Ther</i> <i></i> <i></i> 20: 1 109-115<br/>

http://publicationslist.org/hidekazu.suzuki/refid43 2008-03-19T11:16:42Z

BACKGROUND: Helicobacter pylori resistance to clarithromycin, probably due to the frequent use of this antibiotic for the treatment of other diseases, is the greatest obstacle against its eradication. AIM: To clarify the prevalence of clarithromycin-resistant H. pylori in patients with non-tuberculous mycobacterial lung disease receiving multiple antibiotic treatment, including clarithromycin. MET...<br/><br/>F Kaneko, H Suzuki, N Hasegawa, K Kurabayshi, H Saito, S Otani, H Nakamizo, K Kawata, M Miyairi, K Ishii, H Ishii (2004) <i>Aliment Pharmacol Ther</i> <i></i> <i></i> 20 Suppl 1: 62-67<br/>

http://publicationslist.org/hidekazu.suzuki/refid46 2008-03-19T11:16:42Z

BACKGROUND/AIMS: Problems after Helicobacter pylori (Hp) eradication therapy include recurrence of Hp-negative peptic ulcers. We investigated the pathophysiological characteristics of Hp-negative recurrent ulcer scars, and performed proton pump inhibitor (PPI) maintenance therapy as a new therapy for prevention of recurrence in patients with Hp-negative recurrence after Hp eradication and investig...<br/><br/>Tadashi Ohara, Tetsuo Morishita, Hidekazu Suzuki, Tatsuhiro Masaoka, Hiromasa Ishii (2004) <i>Hepatogastroenterology</i> <i></i> <i></i> 51: 56 338-342<br/>

http://publicationslist.org/hidekazu.suzuki/refid48 2008-03-19T11:16:42Z

Cell proliferation and migration are important repair mechanisms in cell defect type mucosal injuries, such as peptic ulcers. To evaluate the level of cell restitution in vitro, we established a normalized assay system for analyzing the area of a tissue defect created in the center of a cultured cell layer. Although proton pump inhibitors are known to be potently effective in the treatment of pept...<br/><br/>Hidekazu Suzuki, Tatsuhiro Masaoka, Yuriko Minegishi, Yuichiro Motosugi, Soichiro Miura, Hiromasa Ishii (2004) <i>Wound Repair Regen</i> <i></i> <i></i> 12: 1 93-99<br/>

http://publicationslist.org/hidekazu.suzuki/refid49 2008-03-19T11:16:42Z

BACKGROUND: and aim: Although ghrelin, a novel growth hormone releasing peptide localised mainly in the gastric fundus, is reported not only to accelerate food passage and gastrointestinal motility but also to affect appetite and weight control, regulation of gastric ghrelin secretion under the conditions of gastric Helicobacter pylori infection is unknown. The present study was designed to invest...<br/><br/>H Suzuki, T Masaoka, H Hosoda, T Ota, Y Minegishi, S Nomura, K Kangawa, H Ishii (2004) <i>Gut</i> <i></i> <i></i> 53: 2 187-194<br/>

http://publicationslist.org/hidekazu.suzuki/refid42 2008-03-19T11:16:42Z

BACKGROUND: Although Helicobacter pylori infection is now acknowledged as a major promoter of gastric cancer in humans, the carcinogenetic process of this effect has not been fully elucidated. Precancerous lesions such as intestinal metaplasia, enhanced proliferation of epithelial cells and elevated level of growth factors have been postulated to play a role. AIM: To analyse a relationship between...<br/><br/>M Suzuki, H Suzuki, T Masaoka, S Tanaka, K Suzuki, H Ishii (2004) <i>Aliment Pharmacol Ther</i> <i></i> <i></i> 20 Suppl 1: 158-164<br/>

http://publicationslist.org/hidekazu.suzuki/refid47 2008-03-19T11:16:42Z

We have demonstrated anti-proliferation and anti-metastasis effects of both interferon-alpha and a histone deacetylase inhibitor, sodium butyrate, on human liver cancer cell lines. In this study, invasive ability of human liver cancer cell lines through the matrix-coated membrane was examined and inhibitory effect of interferon-alpha and sodium butyrate was investigated. Among six human liver canc...<br/><br/>Fumihiko Kaneko, Hidetsugu Saito, Yoshimasa Saito, Kanji Wakabayashi, Nobuhiro Nakamoto, Shinichiro Tada, Hidekazu Suzuki, Satoshi Tsunematsu, Naoki Kumagai, Hiromasa Ishii (2004) <i>Int J Oncol</i> <i></i> <i></i> 24: 4 837-845<br/>

http://publicationslist.org/hidekazu.suzuki/refid41 2008-03-19T11:16:42Z

A 47-year-old woman was admitted to our hospital with complaints of fever, upper abdominal pain, and back pain. The serum amylase, C-reactive protein (CRP), and IgG (especially IgG4) were elevated, and abdominal computed tomography (CT) revealed diffuse enlargement of the pancreas and pseudocysts. Endoscopic retrograde pancreatography (ERP) revealed diffuse irregular narrowing of the main pancreat...<br/><br/>Tomoyasu Nishimura, Tatsuhiro Masaoka, Hidekazu Suzuki, Kouichi Aiura, Hiroshi Nagata, Hiromasa Ishii (2004) <i>J Gastroenterol</i> <i></i> <i></i> 39: 10 1005-1010<br/>

http://publicationslist.org/hidekazu.suzuki/refid111 2008-03-19T11:37:06Z

OBJECTIVE: Although curative treatment of Helicobacter pylori infection markedly reduces the relapse of peptic ulcers, the details of the ulcers that do recur is not well characterized. The aim of this study is to describe the recurrence rate and specific features of peptic ulcers after cure of H. pylori infection. METHODS: This was a multicenter study involving 4940 peptic ulcer patients who were...<br/><br/>Hiroto Miwa, Nobuhiro Sakaki, Kentaro Sugano, Hitoshi Sekine, Kazuhide Higuchi, Naomi Uemura, Mototsugu Kato, Kazunari Murakami, Chieko Kato, Akiko Shiotani, Toshifumi Ohkusa, Atsushi Takagi, Nobuo Aoyama, Ken Haruma, Kazuichi Okazaki, Kazuo Kusugami, Masayuki Suzuki, Takashi Joh, Takeshi Azuma, Akinori Yanaka, Hidekazu Suzuki, Hiroshi Hashimoto, Takashi Kawai, Toshiro Sugiyama (2004) <i>Helicobacter</i> 9: 1 9-16<br/>

http://publicationslist.org/hidekazu.suzuki/refid30 2008-03-19T11:03:49Z

BACKGROUND: The effects of bacterial eradication therapy cannot be fully explained simply by elimination of the target bacteria, if one considers the effects of eradication therapy in H. pylori-negative cases of low-grade malignancy MALTomas of the rectum. The present study was undertaken to examine the possibility and mechanism of direct induction of apoptosis of the tumor cells by the antibiotic...<br/><br/>Tadashi Ohara, Tetsuo Morishita, Hidekazu Suzuki, Tatsuhiro Masaoka, Hiromasa Ishii, Toshifumi Hibi (2004) <i>Anticancer Res</i> <i></i> <i></i> 24: 6 3723-3730<br/>

http://publicationslist.org/hidekazu.suzuki/refid34 2008-03-19T11:03:49Z

Human beta-defensins (HBDs) recognized in the stomach include HBD1, which is the constitutional human beta-defensin (HBD), and HBD-2 and HBD-4, which are inducible HBDs. HBD-2 is an antimicrobial peptide that is involved in host defences against bacterial infections, such as Helicobacter pylori (H.pylori) in infection of the gastric mucosal epithelium. We examined the pathophysiological role of HB...<br/><br/>Tadashi Ohara, Tetsuo Morishita, Hidekazu Suzuki, Tatsuhiro Masaoka, Hiroshi Nagata, Toshifumi Hibi (2004) <i>Int J Mol Med</i> <i></i> <i></i> 14: 6 1023-1027<br/>

http://publicationslist.org/hidekazu.suzuki/refid33 2008-03-19T11:03:49Z

The capacity of lymph nodes to eradicate cancer is a controversial issue. The purpose of this study was to determine the interplay between tumor growth and host resistance at early stages of lymph node metastasis. A metastasis model was made in the rat mesenteric lymph node, and migration of cancer cells was visualized in vivo. The lymph node was removed for histologic analysis and cytokine measur...<br/><br/>Hiroshi Nagata, Tsunenori Arai, Yusuke Soejima, Hidekazu Suzuki, Hiromasa Ishii, Toshifumi Hibi (2004) <i>Cancer Res</i> <i></i> <i></i> 64: 22 8239-8248<br/>

http://publicationslist.org/hidekazu.suzuki/refid35 2008-03-19T11:03:49Z

BACKGROUND/AIMS: Ghrelin, a novel growth-hormone-releasing peptide, has been reported to be localized mainly in the A-like cells in the gastric fundic mucosa. With the extension of gastric inflammation caused by H. pylori infection, gastric mucosal atrophy extends from the antrum to the corpus, which is the predominant site of localization of the ghrelin-producing A-like cells. The present study w...<br/><br/>Hidekazu Suzuki, Tatsuhiro Masaoka, Hiroshi Hosoda, Sachiko Nomura, Tadashi Ohara, Kenji Kangawa, Hiromasa Ishii, Toshifumi Hibi (2004) <i>Hepatogastroenterology</i> <i></i> <i></i> 51: 59 1249-1254<br/>

http://publicationslist.org/hidekazu.suzuki/refid36 2008-03-19T11:03:49Z

Recently, chicken egg yolk was recognized as an inexpensive antibody source, and the therapeutic usefulness of egg yolk immunoglobulin Y (IgY) in oral passive immunization has been investigated. Although multiple antibiotic treatments eradicate most Helicobacter pylori (H. pylori) infections, therapy fails in 10-15% of cases due to the development of drug resistance. Consequently, it is important ...<br/><br/>H Suzuki, S Nomura, T Masaoka, H Goshima, N Kamata, Y Kodama, H Ishii, M Kitajima, K Nomoto, T Hibi (2004) <i>Aliment Pharmacol Ther</i> <i></i> <i></i> 20 Suppl 1: 185-192<br/>

http://publicationslist.org/hidekazu.suzuki/refid54 2008-03-19T11:16:42Z

Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin leve...<br/><br/>Tatsuhiro Masaoka, Hidekazu Suzuki, Hiroshi Hosoda, Takayuki Ota, Yuriko Minegishi, Hiroshi Nagata, Kenji Kangawa, Hiromasa Ishii (2003) <i>FEBS Lett</i> <i></i> <i></i> 541: 1-3 64-68<br/>

http://publicationslist.org/hidekazu.suzuki/refid55 2008-03-19T11:29:08Z

Ceramides have emerged as key participants in the signaling pathway of cytokines and apoptosis. We previously revealed that phorbol 12-myristate 13-acetate (PMA) induced experimental ulcers in rat gastric mucosa. In this study, we investigated the role of ceramide in ulcer formation and its relation to the activation of transcription factors and apoptosis. PMA was subserosally injected to rat glan...<br/><br/>Keita Uehara, Soichiro Miura, Tetsu Takeuchi, Takao Taki, Manabu Nakashita, Masayuki Adachi, Toshiaki Inamura, Toshiko Ogawa, Yasutada Akiba, Hidekazu Suzuki, Hiroshi Nagata, Hiromasa Ishii (2003) <i>J Pharmacol Exp Ther</i> <i></i> <i></i> 305: 1 232-239<br/>

http://publicationslist.org/hidekazu.suzuki/refid53 2008-03-19T11:16:42Z

Deregulated cell turnover in Helicobacter pylori (H. pylori)-colonized gastric mucosa has been suggested to be linked to the gastric carcinogenesis pathway. We previously reported attenuation of apoptosis and enhancement of cellular proliferation in the H. pylori-colonized gastric mucosa of Mongolian gerbils as compared to that in mice, which might reflect a specific link between H. pylori coloniz...<br/><br/>Masaharu Miyazawa, Hidekazu Suzuki, Tatsuhiro Masaoka, Akemi Kai, Makoto Suematsu, Hiroshi Nagata, Soichiro Miura, Hiromasa Ishii (2003) <i>Free Radic Biol Med</i> <i></i> <i></i> 34: 12 1621-1630<br/>

http://publicationslist.org/hidekazu.suzuki/refid50 2008-03-19T11:16:42Z

BACKGROUND/AIMS: The perforin/granzyme and Fas/Fas ligand pathways are two known major pathways of cytotoxic T lymphocyte-mediated apoptosis. We designed a clinical study to examine whether cytotoxic T lymphocyte-mediated apoptosis associated with peptic ulcer formation may occur via either or both of these two pathways. METHODOLOGY: Mucosal biopsy specimens were obtained endoscopically from the m...<br/><br/>Tadashi Ohara, Tetsuo Morishita, Hidekazu Suzuki, Tatsuhiro Masaoka, Hiromasa Ishii (2003) <i>Hepatogastroenterology</i> <i></i> <i></i> 50: 54 1774-1779<br/>

http://publicationslist.org/hidekazu.suzuki/refid52 2008-03-19T11:16:42Z

BACKGROUND AND AIM: Although rabeprazole (RPZ), a proton pump inhibitor, has been reported to have a bactericidal effect on Helicobacter pylori (H. pylori), no studies have been conducted regarding the effect of RPZ on gastric mucosal lesion formation caused by this bacterium. In the present study, we investigated the effect of RPZ on H. pylori-associated gastric mucosal lesion formation. METHODS:...<br/><br/>Hidekazu Suzuki, Masaharu Miyazawa, Shoichi Nagahashi, Masaru Sato, Motoaki Bessho, Hiroshi Nagata, Soichiro Miura, Hiromasa Ishii (2003) <i>J Gastroenterol Hepatol</i> <i></i> <i></i> 18: 7 787-795<br/>

http://publicationslist.org/hidekazu.suzuki/refid51 2008-03-19T11:16:42Z

Helicobacter pylori (H. pylori) is a spiral shaped bacterium that resides in the stomach mucosa. Isolation of H. pylori from the stomach mucosa changed the erstwhile widely held belief that the stomach contains no bacteria and is actually sterile. Once H. pylori is safely ensconced in the mucus, it is able to neutralize the acid in the stomach by elaborating an enzyme called urease. Urease convert...<br/><br/>Hidekazu Suzuki, Tatsuhiro Masaoka, Sachiko Nomura, Yoshinori Hoshino, Kumiko Kurabayashi, Yuriko Minegishi, Masayuki Suzuki, Hiromasa Ishii (2003) <i>Keio J Med</i> <i></i> <i></i> 52: 3 163-173<br/>

http://publicationslist.org/hidekazu.suzuki/refid61 2008-03-19T11:29:08Z

AIM: To examine whether proton pump inhibitors modify the production of oxygen-derived free radicals and related cytokines in the human gastric mucosa infected with H. pylori. METHODS: Thirty-four H. pylori-positive peptic ulcer patients (23 gastric ulcer, 11 duodenal ulcer) were enrolled. Biopsy tissue samples were obtained endoscopically from the antrum and corpus. Tissue content of neutrophil m...<br/><br/>M Suzuki, H Suzuki, T Kitahora, M Miyazawa, S Nagahashi, K Suzuki, H Ishii (2002) <i>Aliment Pharmacol Ther</i> <i></i> <i></i> 16 Suppl 2: 229-234<br/>

http://publicationslist.org/hidekazu.suzuki/refid64 2008-03-19T11:29:08Z

Although gastric cancer formation with H. pylori in Mongolian gerbils was recently reported, the same inoculation procedure did not result in cancer formation in other animals such as mice. Disturbed regulation of apoptosis and cell proliferation are known to link the multistep process of carcinogenesis. The present study is designed to examine the level of gastric epithelial cell apoptosis in Mon...<br/><br/>Hidekazu Suzuki, Masaharu Miyazawa, Shoichi Nagahashi, Mikiji Mori, Koichi Seto, Akemi Kai, Masayuki Suzuki, Soichiro Miura, Hiromasa Ishii (2002) <i>Dig Dis Sci</i> <i></i> <i></i> 47: 1 90-99<br/>

http://publicationslist.org/hidekazu.suzuki/refid60 2008-03-19T11:29:08Z

BACKGROUND: Although oxygen-derived free radicals are known to play a role in cell injury and DNA alterations, the role of active oxidants in chronic pancreatitis has not been fully elucidated. Using WBN/Kob rats, which spontaneously develop chronic pancreatitis-like lesions, we investigated whether xanthine oxidase (XOD)-derived oxygen radicals are involved in pancreatic tissue injury. METHODS: W...<br/><br/>Shigeyuki Zeki, Soichiro Miura, Hidekazu Suzuki, Naoyuki Watanabe, Masayuki Adachi, Hirokazu Yokoyama, Yoshinori Horie, Hidetsugu Saito, Shinzo Kato, Hiromasa Ishii (2002) <i>J Gastroenterol Hepatol</i> <i></i> <i></i> 17: 5 606-616<br/>

http://publicationslist.org/hidekazu.suzuki/refid62 2008-03-19T11:29:08Z

BACKGROUND: We previously reported that attenuated epithelial apoptosis and enhanced proliferation in comparison with mice might link to the specific carcinogenesis in Mongolian gerbils and suggested that the difference in both strains might be due to a difference in genetic background. p53 is a well-known tumour suppressor gene, mutation of which is also known to be involved in gastric cancer for...<br/><br/>H Suzuki, M Miyazawa, A Kai, M Suzuki, M Suematsu, S Miura, H Ishii (2002) <i>Aliment Pharmacol Ther</i> <i></i> <i></i> 16 Suppl 2: 158-166<br/>

http://publicationslist.org/hidekazu.suzuki/refid59 2008-03-19T11:29:08Z

Although intestinal epithelial cells (IECs) are known as an important source for IL-6, it is not known whether mechanical forces affect IL-6 production. We investigated how transmural pressure modulates IL-6 synthesis and activation of transcription factors in IECs. Pressure was loaded onto IEC-18 cells by introducing compressed helium gas into the cell culture flask for 1-48 h. IL-6 release into ...<br/><br/>H Kishikawa, S Miura, H Yoshida, M Hirokawa, H Nakamizo, H Higuchi, M Adachi, R C Nakatsumi, H Suzuki, H Saito, H Ishii (2002) <i>Clin Exp Immunol</i> <i></i> <i></i> 129: 1 86-91<br/>

http://publicationslist.org/hidekazu.suzuki/refid57 2008-03-19T11:29:08Z

Although T cell involvement in Helicobactor pylori-induced gastritis is known, mechanism about T cell recruitment is not understood. In this study we examined how mucosal addressin cell adhesion -molecule-1 (MAdCAM-1) is involved in lymphocyte recruitment in murine chronic gastritis induced by H. pylori. C57 BL/6 mice were infected with Sydney strain (SS1). Six months after infection, the stomach ...<br/><br/>K Hatanaka, R Hokari, K Matsuzaki, S Kato, A Kawaguchi, S Nagao, H Suzuki, K Miyazaki, E Sekizuka, H Nagata, H Ishii, S Miura (2002) <i>Clin Exp Immunol</i> <i></i> <i></i> 130: 2 183-189<br/>

http://publicationslist.org/hidekazu.suzuki/refid124 2008-03-19T11:51:38Z

Evidence is increasing in hypertensive models for an inflammatory reaction in the microcirculation with abnormal leukocyte counts and adhesion to the endothelium, enhanced arteriolar tone, and microvascular and tissue apoptosis. The spontaneous form of hypertension (SHR) is accompanied by a glucocorticoid-dependent increase in circulating leukocyte count with elevated levels of activation and at t...<br/><br/>Makoto Suematsu, Hidekazu Suzuki, Frank A Delano, Geert W Schmid-Schönbein (2002) <i>Microcirculation</i> <i></i> <i></i> 9: 4 259-276<br/>

http://publicationslist.org/hidekazu.suzuki/refid58 2008-03-19T11:29:08Z

The relationship between Helicobacter pylori colonization and the formation of stress-induced gastric mucosal injury remains unknown. Since ammonia (NH(3)) is known as one of the injurious factors in H. pylori-colonized gastric mucosa, the present study is designed to investigate the level of stress-induced gastric mucosal oxidative injury with or without intragastric NH(3) overloading. To apply e...<br/><br/>Shoichi Nagahashi, Hidekazu Suzuki, Masaharu Miyazawa, Hiroshi Nagata, Masayuki Suzuki, Soichiro Miura, Hiromasa Ishii (2002) <i>Free Radic Biol Med</i> <i></i> <i></i> 33: 8 1073-1081<br/>

http://publicationslist.org/hidekazu.suzuki/refid63 2008-03-19T11:29:08Z

BACKGROUND: Proton pump inhibitors have been reported to modify the level of Helicobacter pylori gastritis. AIM: To quantitatively investigate the effect of a proton pump inhibitor on the mucosal neutrophil reaction. METHODS: Forty-six H. pylori-infected patients (17 duodenal ulcer, 29 gastric ulcer) were enrolled. During endoscopic examination, biopsy samples were obtained from the antrum and the...<br/><br/>M Suzuki, H Suzuki, T Kitahora, M Miyazawa, S Nagahashi, K Suzuki, H Ishii (2002) <i>Aliment Pharmacol Ther</i> <i></i> <i></i> 16: 1 159-165<br/>

http://publicationslist.org/hidekazu.suzuki/refid56 2008-03-19T11:29:08Z

Since Marshall's discovery before 20 years, Helicobacter pylori (H. pylori) infection is reportedly to be associated with a variety of clinical outcomes including peptic ulcer disease and gastric cancer. The first step of the H. pylori colonization might be its adhesion to the surface epithelial cells, which evokes gastric inflammatory events initiated by neutrophil recruitment from the microcircu...<br/><br/>Hidekazu Suzuki, Tatsuhiro Masaoka, Masaharu Miyazawa, Masayuki Suzuki, Soichiro Miura, Hiromasa Ishii (2002) <i>Keio J Med</i> <i></i> <i></i> 51 Suppl 2: 40-44<br/>

http://publicationslist.org/hidekazu.suzuki/refid67 2008-03-19T11:29:08Z

BACKGROUND: Human gastric mucosa contains three alcohol dehydrogenase (ADH) isozymes (classes I, III, and IV). Various factors such as Helicobacter pylori infection, sex, age, and the part of the stomach involved have been suggested to affect alcohol dehydrogenase activities, although these views are controversial. In this study, these unsettled issues were reexamined. METHODS: Activities of class...<br/><br/>M Matsumoto, H Yokoyama, H Shiraishi, H Suzuki, S Kato, S Miura, H Ishii (2001) <i>Alcohol Clin Exp Res</i> <i></i> <i></i> 25: 6 Suppl 29S-34S<br/>

http://publicationslist.org/hidekazu.suzuki/refid71 2008-03-19T11:29:08Z

BACKGROUND/AIMS: Cytokine-induced neutrophil chemoattractant (CINC/gro), a member of interleukin-8 family, was found as a potent chemotactic factor for rat neutrophils. Although several chemokines have been shown to be potent regulators of T cell chemotaxis in vitro, the potential role of chemokines in T-cell migration in gut-associated lymphoid tissues has not been investigated in vivo. In the pr...<br/><br/>H Fujimori, S Miura, S Koseki, R Hokari, Y Tsuzuki, S Komoto, Y Hara, H Suzuki, H Serizawa, H Ishii (2001) <i>Digestion</i> <i></i> <i></i> 63 Suppl 1: 97-102<br/>

http://publicationslist.org/hidekazu.suzuki/refid70 2008-03-19T11:29:08Z

Although the negative effect of excessive alcohol consumption on later stressful events has long been recognized, pathophysiological mechanisms are incompletely understood. We examined possible roles of oxygen radicals and glutathione content in mesenteric venules of chronically ethanol-fed rats exposed to ischemia-reperfusion. Changes in microvascular hemodynamics, such as red blood cell (RBC) ve...<br/><br/>J Y Han, S Miura, Y Akiba, H Higuchi, S Kato, H Suzuki, H Yokoyama, H Ishii (2001) <i>Am J Physiol Gastrointest Liver Physiol</i> <i></i> <i></i> 280: 5 G939-G948<br/>

http://publicationslist.org/hidekazu.suzuki/refid68 2008-03-19T11:29:08Z

BACKGROUND: We previously demonstrated that Helicobacter pylori colonization evokes gastric mucosal inflammation and an extensive increase in lipid peroxides and glutathione in Mongolian gerbils. Zinc and its derivative, polaprezinc, have been reported to be potent antioxidants in gastric mucosa. AIM: To examine the effect of polaprezinc on gastric mucosal oxidative inflammation in H. pylori-colon...<br/><br/>H Suzuki, M Mori, K Seto, M Miyazawa, A Kai, M Suematsu, T Yoneta, S Miura, H Ishii (2001) <i>Aliment Pharmacol Ther</i> <i></i> <i></i> 15: 5 715-725<br/>

http://publicationslist.org/hidekazu.suzuki/refid66 2008-03-19T11:29:08Z

Intestinal mucosa is continuously exposed to mechanical forces. We examined whether pressure loading activates mitogen-activated protein kinase (MAPK) and expression of early immediate genes in intestinal epithelial cells. Pressure was applied to IEC18 cells by helium gas in a culture flask and pressure-induced cell proliferation was examined. The expression of early immediate genes, MAPK activity...<br/><br/>M Hirokawa, S Miura, H Kishikawa, H Yoshida, H Nakamizo, H Higuchi, R C Nakatsumi, H Suzuki, H Saito, H Ishii (2001) <i>Dig Dis Sci</i> <i></i> <i></i> 46: 9 1993-2003<br/>

http://publicationslist.org/hidekazu.suzuki/refid65 2008-03-19T11:29:08Z

Intestinal mucosal immunity is modulated by cytokine release from intestinal cells, but little is known about the relation between nutrient absorption and cytokine release. In this study, we examined how exposure to fatty acids affects the production of growth-regulated oncogene/cytokine-induced neutrophil chemoattractant-1 (GRO/CINC-1) and interleukin (IL)-6 in rat intestinal epithelial cells (IE...<br/><br/>H Yoshida, S Miura, H Kishikawa, M Hirokawa, H Nakamizo, R C Nakatsumi, H Suzuki, H Saito, H Ishii (2001) <i>J Nutr</i> <i></i> <i></i> 131: 11 2943-2950<br/>

http://publicationslist.org/hidekazu.suzuki/refid72 2008-03-19T11:29:08Z

BACKGROUND: CXC chemokines such as interleukin (IL)-8 are neutrophil chemoattractants, the levels of which increase in Helicobacter pylori-infected gastric mucosa. Many investigators have focused on the chemotactic aspects of IL-8: however, CXC chemokines are also reported to have angiogenic activity and to serve as remodelling factors. Rat GRO/CINC-1 is a rodent counterpart of human GROalpha, a m...<br/><br/>H Suzuki, M Mori, K Seto, F Shibata, S Nagahashi, C Kawaguchi, M Suzuki, H Matsui, K Watanabe, S Miura, H Ishii (2000) <i>Aliment Pharmacol Ther</i> <i></i> <i></i> 14 Suppl 1: 94-100<br/>

http://publicationslist.org/hidekazu.suzuki/refid73 2008-03-19T11:29:08Z

Apoptosis, a programmed cell death, was ignored, just like Helicobacter pylori, only to reappear recently. However, the number of current publications dealing with apoptosis or H. pylori has increased exponentially. Although gastric epithelial apoptosis is a programmed physiological event in the superficial aspect of the mucosa and is important for healthy cell turnover, H. pylori infection report...<br/><br/>H Suzuki, H Ishii (2000) <i>J Gastroenterol Hepatol</i> <i></i> <i></i> 15 Suppl: D46-D54<br/>

http://publicationslist.org/hidekazu.suzuki/refid69 2008-03-19T11:29:08Z

Macrophages beneath the marginal sinus in the lymph nodes may play a role in defense against microorganism. The purpose of this study was to directly visualize the parasinus macrophages in the mesenteric lymph node. Fluorescent latex particles were injected into the appendix submucosa of rats. The mesenteric lymph node was epi-illuminated and observed with a fluorescent microscope. Fluorescent par...<br/><br/>H Nagata, R Hokari, H Suzuki, S Miura, E Sekizuka, H Ishii (2000) <i>Clin Hemorheol Microcirc</i> <i></i> <i></i> 23: 2-4 345-348<br/>

http://publicationslist.org/hidekazu.suzuki/refid81 2008-03-19T11:29:08Z

BACKGROUND: Spontaneously hypertensive rats (SHR) are a representative animal model for disturbance of the pituitary-adrenal axis, as well as disturbance of the autonomic nervous system. METHODS AND RESULTS: In this study, we showed that adrenalectomy in SHR-induced spontaneous gastric ulcer formation. We further investigated how abnormal adrenal secretion is related to the attenuation of gastric ...<br/><br/>H Suzuki, S Miura, M Mori, Y Akiba, S Nagahashi, B W Zweifach, H Ishii, G W Schmid-Schönbein (1999) <i>J Gastroenterol Hepatol</i> <i></i> <i></i> 14: 4 376-383<br/>

http://publicationslist.org/hidekazu.suzuki/refid82 2008-03-19T11:29:08Z

In this study, the influence of omeprazole on the adhesive activity of neutrophils, provided by an extract of Helicobacter pylori, was determined. Human neutrophils were collected from peripheral blood and labelled with a fluorochrome. Helicobacter pylori (NCTC 11637) was cultured and its water extract was obtained by centrifugation of the bacterial suspension. Neutrophils were incubated with the ...<br/><br/>M Suzuki, M Mori, D Fukumura, H Suzuki, S Miura, H Ishii (1999) <i>J Gastroenterol Hepatol</i> <i></i> <i></i> 14: 1 27-31<br/>

http://publicationslist.org/hidekazu.suzuki/refid83 2008-03-19T11:29:08Z

Although vascular endothelial growth factor (VEGF) plays a role in the growth of hypervascular tumors, mechanisms for paracrine regulation of its receptor expression on vascular endothelial cells remain unknown. This study aimed to investigate whether VEGF released from hypoxia-exposed Hep G2 cells alters expression of the two distinct receptors, kinase insert domain-containing receptor (KDR) and ...<br/><br/>H Suzuki, K Seto, Y Shinoda, M Mori, Y Ishimura, M Suematsu, H Ishii (1999) <i>Am J Physiol</i> <i></i> <i></i> 276: 1 Pt 1 G92-G97<br/>

http://publicationslist.org/hidekazu.suzuki/refid79 2008-03-19T11:29:08Z

We previously reported that in vitro hypoxic condition enhanced VEGF level and its receptor expression in hepatic cancer cell line, HepG2. Transcatheter hepatic arterial embolization (TAE) therapy is one of the vasculo-occlusive and hypoxic challenges to hepatocellular carcinoma (HCC). Therefore, we examined the level of VEGF in sera of patients with HCC who underwent TAE during the course of the ...<br/><br/>H Suzuki, M Mori, C Kawaguchi, M Adachi, S Miura, H Ishii (1999) <i>Int J Oncol</i> <i></i> <i></i> 14: 6 1087-1090<br/>

http://publicationslist.org/hidekazu.suzuki/refid125 2008-03-19T11:51:38Z

The mechanisms that lead to organ injury in hypertension are incompletely understood. In particular, there is a lack of evidence that serves to link the elevation of arterial blood pressure with end organ damage. Experimental models of hypertension have a range of microvascular abnormalities in addition to a shift in blood pressure. There is evidence for an oxidative stress in microvascular endoth...<br/><br/>H Suzuki, M Suematsu, G W Schmid-Schönbein (1999) <i>Clin Hemorheol Microcirc</i> <i></i> <i></i> 21: 3-4 161-168<br/>

http://publicationslist.org/hidekazu.suzuki/refid80 2008-03-19T11:29:08Z

Helicobacter pylori colonized gastric mucosa is manifest in a significant neutrophil infiltration with an extensive level of oxyradical formation. Mongolian gerbil is one of the excellent models for H. pylori-infection. The present study was designed to investigate pro- and antioxidant formation in the stomach of H. pylori-positive gerbils. Fourteen male Mongolian gerbils (MGS/Sea) were orally ino...<br/><br/>H Suzuki, M Mori, K Seto, A Kai, C Kawaguchi, M Suzuki, M Suematsu, T Yoneta, S Miura, H Ishii (1999) <i>Free Radic Biol Med</i> <i></i> <i></i> 26: 5-6 679-684<br/>

http://publicationslist.org/hidekazu.suzuki/refid74 2008-03-19T11:29:08Z

We previously reported that NH2Cl induced extensive DNA fragmentation in gastric cells. Polaprezinc, a zinc-carnosine chelate compound, is reported to be a potent antioxidant in gastric mucosa. The present study was designed to examine whether polaprezinc could attenuate the NH3Cl-induced DNA damage. Gastric cell lines, MKN45, were exposed to NH2Cl in Ca(2+)-containing Hanks' balanced salt solutio...<br/><br/>H Suzuki, M Mori, K Seto, S Nagahashi, C Kawaguchi, H Morita, M Suzuki, S Miura, T Yoneta, H Ishii (1999) <i>J Gastroenterol</i> <i></i> <i></i> 34 Suppl 11: 43-46<br/>

http://publicationslist.org/hidekazu.suzuki/refid76 2008-03-19T11:29:08Z

The role of nitric oxide in ulcer formation remains unknown. Accordingly, we assessed local expression of inducible nitric oxide synthase (NOS) and nitration of tyrosine as an indicator of peroxynitrite formation in patients with Helicobacter pylori (HP)-associated gastric ulcers compared with HP-negative ulcers. Biopsy specimens were taken from the ulcer margin and from an area remote from the ul...<br/><br/>A A Sakaguchi, S Miura, T Takeuchi, R Hokari, M Mizumori, H Yoshida, H Higuchi, M Mori, H Kimura, H Suzuki, H Ishii (1999) <i>Free Radic Biol Med</i> <i></i> <i></i> 27: 7-8 781-789<br/>

http://publicationslist.org/hidekazu.suzuki/refid75 2008-03-19T11:29:08Z

BACKGROUND: Mongolian gerbils have been reported to be a suitable model for Helicobacter pylori-associated gastric mucosal injury, including gastric cancer. Although ethanol is known to be one of the harmful substances in the gastric mucosa, the relationship between ethanol and H. pylori infection remains unknown. The aim of the present study is to investigate the effect of ethanol treatment prior...<br/><br/>H Suzuki, M Mori, K Seto, S Nagahashi, C Kawaguchi, A Kai, Y Akiba, M Suzuki, M Suematsu, S Miura, H Ishii (1999) <i>J Gastroenterol Hepatol</i> <i></i> <i></i> 14: 11 1062-1069<br/>

http://publicationslist.org/hidekazu.suzuki/refid77 2008-03-19T11:29:08Z

This study aimed to examine whether acetaminophen (AAP), an anti-inflammatory agent producing hepatocellular damages with its overdose, evokes hepatocellular dysfunction through mechanisms involving carbon monoxide (CO) generated by heme oxygenase (HO). In perfused rat livers, CO and bilirubin were determined in venous perfusate and bile samples as indices of heme degradation. Biliary excretion of...<br/><br/>M Mori, M Suematsu, T Kyokane, T Sano, H Suzuki, T Yamaguchi, Y Ishimura, H Ishii (1999) <i>Hepatology</i> <i></i> <i></i> 30: 1 160-168<br/>

http://publicationslist.org/hidekazu.suzuki/refid78 2008-03-19T11:29:08Z

The mechanisms contributing to organ injury in hypertension have been incompletely defined. The thymus gland of the spontaneously hypertensive rat (SHR) shows significant atrophy at the age of 15 wk compared with its normotensive control, the Wistar-Kyoto rat (WKY). The aim of the present study was to examine the thymus of SHR for evidence of DNA nicking as one of the mechanisms for thymic atrophy...<br/><br/>H Suzuki, F A Delano, N Jamshidi, D Katz, M Mori, K Kosaki, R A Gottlieb, H Ishii, G W Schmid-Schönbein (1999) <i>Am J Physiol</i> <i></i> <i></i> 276: 6 Pt 2 H2135-H2140<br/>

http://publicationslist.org/hidekazu.suzuki/refid37 2008-03-19T11:03:49Z

Eradication therapy for Helicobacter pylori (H. pylori) has been established. However, the physiological factors influencing the success of treatment remain unclear. The aim of this study was to analyze these factors and to evaluate the efficacy of sofalcone on H. pylori eradication therapy. Forty-four H. pylori-infected and peptic ulcer patients were enrolled in this study. Twenty-seven patients ...<br/><br/>M Suzuki, T Kitahora, S Nagahashi, H Suzuki, M Mori, T Hibi, H Ishii (1998) <i>J Clin Gastroenterol</i> <i></i> <i></i> 27 Suppl 1: S183-S186<br/>

http://publicationslist.org/hidekazu.suzuki/refid88 2008-03-19T11:29:08Z

Endotoxin is postulated to be an important aggravating factor for alcoholic liver disease. We have previously reported that rats fed ethanol are more vulnerable to endotoxin-induced liver damage, and hepatic microcirculatory disturbance plays an important role for this liver damage by observation with an intravital microscopy. In this study, we have investigated the role of adhesion molecules in e...<br/><br/>E Ohki, S Kato, H Ohgo, T Mizukami, M Fukuda, H Tamai, Y Okamura, M Matsumoto, H Suzuki, H Yokoyama, H Ishii (1998) <i>Alcohol Clin Exp Res</i> <i></i> <i></i> 22: 3 Suppl 129S-132S<br/>

http://publicationslist.org/hidekazu.suzuki/refid89 2008-03-19T11:29:08Z

Recent evidence in vivo indicates that spontaneously hypertensive rats (SHR) exhibit an increase in oxyradical production in and around microvascular endothelium. This study is aimed to examine whether xanthine oxidase plays a role in overproduction of oxidants and thereby may contribute to hypertensive states as a consequence of the increasing microvascular tone. The xanthine oxidase activity in ...<br/><br/>H Suzuki, F A DeLano, D A Parks, N Jamshidi, D N Granger, H Ishii, M Suematsu, B W Zweifach, G W Schmid-Schönbein (1998) <i>Proc Natl Acad Sci U S A</i> <i></i> <i></i> 95: 8 4754-4759<br/>

http://publicationslist.org/hidekazu.suzuki/refid38 2008-03-19T11:03:49Z

The possession of the cytotoxin-associated gene (cagA) of Helicobacter pylori is thought to be highly associated with peptic ulcer disease. However, the pathogenic role of cagA is still unknown. We have emphasized the importance of the interrelationship between H. pylori-derived ammonia and oxygen radicals from infiltrated leucocytes. The aim of the present study was to explore the relationship be...<br/><br/>H Suzuki, M Suzuki, M Mori, T Kitahora, H Yokoyama, S Miura, T Hibi, H Ishii (1998) <i>J Gastroenterol Hepatol</i> <i></i> <i></i> 13: 3 294-300<br/>

http://publicationslist.org/hidekazu.suzuki/refid85 2008-03-19T11:29:08Z

Monochloramine (NH2Cl) is known to be one of the virulence factors in Helicobacter pylori-associated gastric mucosal injury. The present study was designed to examine NH2Cl-evoked DNA fragmentation in the gastric epithelial cell line MKN45. NH2Cl was produced by mixing NH3 with sodium hypochlorite (NaClO). MKN45 cells were exposed to NH2Cl, NH3, or NaClO in Hanks' balanced salt solution. DNA cleav...<br/><br/>H Suzuki, K Seto, M Mori, M Suzuki, S Miura, H Ishii (1998) <i>Am J Physiol</i> <i></i> <i></i> 275: 4 Pt 1 G712-G716<br/>

http://publicationslist.org/hidekazu.suzuki/refid86 2008-03-19T11:29:08Z

Helicobacter pylori colonized to gastric mucosa plays an important pathogenic role in gastric mucosal lesions. We previously reported that ethanol pretreatment promotes the extension of H. pylori-associated lesions. The present study was designed to examine the effect of rebamipide, a mucosal protective agent, on H. pylori-associated injury. Male Mongolian gerbils were orally inoculated with H. py...<br/><br/>H Suzuki, M Mori, A Kai, M Suzuki, M Suematsu, S Miura, H Ishii (1998) <i>Dig Dis Sci</i> <i></i> <i></i> 43: 9 Suppl 181S-187S<br/>

http://publicationslist.org/hidekazu.suzuki/refid87 2008-03-19T11:29:08Z

C-X-C Chemokines play an important role for neutrophil extravasation through microvessels. Although the level of interleukin (IL)-8 is known to increase in the Helicobacter pylori-infected gastric mucosa, another C-X-C chemokine, GROalpha, has not been evaluated in the H. pylori-associated gastric mucosal injury. The present study was designed to investigate gastric contents of GROalpha in relatio...<br/><br/>H Suzuki, M Mori, A A Sakaguchi, M Suzuki, S Miura, H Ishii (1998) <i>J Gastroenterol Hepatol</i> <i></i> <i></i> 13: 5 516-520<br/>

http://publicationslist.org/hidekazu.suzuki/refid84 2008-03-19T11:29:08Z

We sought to clarify the role of nitric oxide (NO) generated from inducible NO synthase (iNOS) during healing of rat gastric ulcers. After gastric ulcers were induced by acetic acid, rats were treated with vehicle, N(G)-nitro-L-arginine methyl ester (L-NAME), aminoguanidine (AG), and dexamethasone (Dex) by gastric intubation twice a day for 3 days to 1 week. L-NAME significantly delayed healing co...<br/><br/>Y Akiba, M Nakamura, M Mori, H Suzuki, M Oda, H Kimura, S Miura, M Tsuchiya, H Ishii (1998) <i>J Clin Gastroenterol</i> <i></i> <i></i> 27 Suppl 1: S64-S73<br/>

http://publicationslist.org/hidekazu.suzuki/refid92 2008-03-19T11:29:08Z

Colonization of Helicobacter pylori (Hp) to gastric mucosa plays an important role for the pathogenesis of gastric mucosal lesions. We previously reported the importance of monochloramine (NH2Cl), which was derived from the interaction between Hp-urease and infiltrated leukocytes, in the course of Hp-associated gastric mucosal injury. While the long-term infection of Hp in the gastric mucosa is kn...<br/><br/>H Suzuki, M Mori, M Suzuki, K Sakurai, S Miura, H Ishii (1997) <i>Cancer Lett</i> <i></i> <i></i> 115: 2 243-248<br/>

http://publicationslist.org/hidekazu.suzuki/refid91 2008-03-19T11:29:08Z

BACKGROUND: Previously, we have reported that toxic oxidants produced by activated neutrophils play a pivotal role in the development of Helicobacter pylori-induced gastric mucosal damage. Microorganisms, however, are characterized by their ability to produce a variety of antioxidant enzymes. This study is designed to measure the oxygen radical scavenging enzymes, such as catalase and superoxide d...<br/><br/>M Mori, H Suzuki, M Suzuki, A Kai, S Miura, H Ishii (1997) <i>Helicobacter</i> <i></i> <i></i> 2: 2 100-105<br/>

http://publicationslist.org/hidekazu.suzuki/refid90 2008-03-19T11:29:08Z

Although endotoxin exacerbates hepatic microcirculatory disturbance, little is known of the way in which it acts on the hepatic microcirculation. We measured endotoxin-induced changes in hepatic microcirculation and investigated the effect of endotoxin on hepatic microcirculation in rats. After male Wistar rats were anesthetized, a lobe of the liver was observed with an inverted intravital microsc...<br/><br/>Y Horie, S Kato, E Ohki, H Hamamatsu, D Fukumura, I Kurose, H Suzuki, M Suematsu, S Miura, H Ishii (1997) <i>J Gastroenterol</i> <i></i> <i></i> 32: 6 783-790<br/>

http://publicationslist.org/hidekazu.suzuki/refid39 2008-03-19T11:03:49Z

Neutrophil accumulation plays an important role in Helicobacter pylori-associated gastric mucosal injury. In this study, the mucosal content of myeloperoxidase (MPO), which is a measure of neutrophil accumulation and interleukin-8 (IL-8) was assayed and changes in MPO and IL-8 content were determined before and after H. pylori eradication therapy. Thirty-seven H. pylori-positive patients (11DU/26G...<br/><br/>M Suzuki, M Mori, A Miyayama, N Iwai, N Tsunematsu, M Oonuki, H Suzuki, T Hibi, H Ishii (1997) <i>J Clin Gastroenterol</i> <i></i> <i></i> 25 Suppl 1: S222-S228<br/>

http://publicationslist.org/hidekazu.suzuki/refid138 2009-02-27T11:23:50Z

Morphogenesis of the cardiovascular system is likely linked to its functional development. This report presents an approach to functional assessment of early cardiovascular development using parametric imaging based on videodensitometry. Trypan blue was injected into the sinus venosus of chick embryos at stage 20 (3.5 d of incubation). Images were recorded on videotape, digitized, and analyzed by ...<br/><br/>K Kosaki, H Suzuki, G W Schmid-Schönbein, T R Nelson, K L Jones (1997) <i>Pediatr Res</i> <i></i> <i></i> 41: 4 Pt 1 451-456<br/>

http://publicationslist.org/hidekazu.suzuki/refid102 2008-03-19T11:31:05Z

We previously reported that the response of the arterioles in spontaneously hypertensive rats (SHR) to histamine is blunted compared with that in normotensive control rats (Wistar-Kyoto rats [WKY]). The present study was designed to analyze the extent to which this blunted arteriolar response may be attributed in SHR to the concurrent elevation of circulating glucocorticoids through the use of adr...<br/><br/>H Suzuki, B W Zweifach, G W Schmid-Schönbein (1996) <i>Hypertension</i> <i></i> <i></i> 27: 1 114-118<br/>

http://publicationslist.org/hidekazu.suzuki/refid94 2008-03-19T11:29:08Z

In alcoholic liver disease, endotoxin has been postulated to play an important role in its pathogenesis. Endotoxin is known to lead to impediment of hepatic microcirculation, including the adhesion of leukocytes to sinusoidal endothelial cells. In this study, the effect of chronic ethanol consumption on the leukocyte adhesion elicited by endotoxin was examined. Male Wistar rats were pair-fed with ...<br/><br/>E Ohki, S Kato, Y Horie, T Mizukami, H Tamai, H Yokoyama, D Ito, M Fukuda, H Suzuki, I Kurose, H Ishii (1996) <i>Alcohol Clin Exp Res</i> <i></i> <i></i> 20: 9 Suppl 350A-355A<br/>

http://publicationslist.org/hidekazu.suzuki/refid95 2008-03-19T11:29:08Z

Helicobacter pylori are believed to play an important role in the formation of gastric ulcer in a syndrome characterized by a high urease activity. On the other hand, the production of oxygen radicals and platelet activating factor (PAF) is enhanced in gastric ulcers. The present study is designed to investigate the relationship between the different aspects of gastric mucosal injury, urease activ...<br/><br/>H Suzuki, S Miura, H Imaeda, M Suzuki, J Y Han, M Mori, D Fukumura, M Tsuchiya, H Ishii (1996) <i>Free Radic Biol Med</i> <i></i> <i></i> 20: 3 449-454<br/>

http://publicationslist.org/hidekazu.suzuki/refid93 2008-03-19T11:29:08Z

Although small intestine is frequently injured in endotoxin shock, the exact pathological sequence has not been fully understood. The major objective of this study is to elucidate the role of interleukin (IL)-1 in endotoxin-induced microcirculatory disturbance of rat small intestine. Mucosal and submucosal microvessels of the rat ileum were observed by intravital microscope with a high speed video...<br/><br/>D Fukumura, S Miura, I Kurose, H Higuchi, H Suzuki, H Ebinuma, J Y Han, N Watanabe, G Wakabayashi, M Kitajima, H Ishii (1996) <i>Dig Dis Sci</i> <i></i> <i></i> 41: 12 2482-2492<br/>

http://publicationslist.org/hidekazu.suzuki/refid106 2008-03-19T11:31:05Z

Recent evidence suggests that spontaneously hypertensive rats (SHR) exhibit an impaired response to inflammatory mediators. We designed this study to analyze the response of arterioles of SHR after stimulation with a proinflammatory agent, histamine, compared with the response of arterioles of normotensive Wistar-Kyoto (WKY) controls. We observed mesenteric arterioles by intravital microscopy in r...<br/><br/>H Suzuki, B W Zweifach, G W Schmid-Schönbein (1995) <i>Hypertension</i> <i></i> <i></i> 26: 3 397-400<br/>

http://publicationslist.org/hidekazu.suzuki/refid105 2008-03-19T11:31:05Z

The present study was designed to elucidate whether molecular mechanisms for leukocyte adhesion to microvascular endothelium may differ between spontaneously hypertensive rats and Wistar Kyoto rats. Leukocyte rolling and adhesion were investigated while monitoring venular wall shear rates in the mesenteric microcirculation stimulated with histamine or tert-butyl hydroperoxide in the two strains. I...<br/><br/>M Suematsu, H Suzuki, T Tamatani, Y Iigou, F A DeLano, M Miyasaka, M J Forrest, R Kannagi, B W Zweifach, Y Ishimura (1995) <i>J Clin Invest</i> <i></i> <i></i> 96: 4 2009-2016<br/>

http://publicationslist.org/hidekazu.suzuki/refid96 2008-03-19T11:29:08Z

Substance P (SP), one of the established neurotransmitters, evokes an immunoinflammatory response involving leukocyte adhesion to venular endothelium and the degranulation of mast cells. The pathogenetic relationship between these responses, however, remains unresolved. In this study, we propose to examine the changes associated with the activation of mast cells, as well as leukocyte adhesion to v...<br/><br/>H Suzuki, S Miura, Y Y Liu, M Tsuchiya, H Ishii (1995) <i>Peptides</i> <i></i> <i></i> 16: 8 1447-1452<br/>

http://publicationslist.org/hidekazu.suzuki/refid116 2008-03-19T11:47:08Z

S Tanaka, S Miura, H Suzuki, N Ohkubo, H Imaeda, H Shiozaki, H Tashiro, H Serizawa, M Tsuchiya (1995) <i>Adv Exp Med Biol</i> <i></i> <i></i> 371B: 1395-1398<br/>

http://publicationslist.org/hidekazu.suzuki/refid104 2008-03-19T11:31:05Z

This study is designed to explore the effect of adrenal glucocorticoids on arteriolar behavior under steady state conditions in spontaneously hypertensive rats (SHR) compared with their normotensive controls, the Wistar Kyoto (WKY) rats. Mesenteric arterioles were observed by intravital microscopy under general anesthesia and arteriolar diameters were measured. At the end of each experiment, papav...<br/><br/>H Suzuki, B W Zweifach, G W Schmid-Schönbein (1995) <i>Int J Microcirc Clin Exp</i> <i></i> <i></i> 15: 6 309-315<br/>

http://publicationslist.org/hidekazu.suzuki/refid107 2008-03-19T11:31:05Z

The factors that predispose to the accelerated organ injury that accompanies the hypertensive syndrome have remained speculative and without a firm experimental basis. Indirect evidence has suggested that a key feature may be related to an enhanced oxygen radical production. The purpose of this study was to refine and use a technique to visualize evidence of spontaneous microvascular oxidative str...<br/><br/>H Suzuki, A Swei, B W Zweifach, G W Schmid-Schönbein (1995) <i>Hypertension</i> <i></i> <i></i> 25: 5 1083-1089<br/>

http://publicationslist.org/hidekazu.suzuki/refid108 2008-03-19T11:31:05Z

Leukocyte adhesion is a key factor in the pathogenesis of organ injury following a variety of stimuli. In this study we have addressed the role of leukocyte adhesion in hypertensives as a risk factor for organ injury. In the spontaneously hypertensive rat (SHR), the number of circulating leukocytes and their level of activation are significantly increased compared with its normotensive control, th...<br/><br/>H Suzuki, B W Zweifach, M J Forrest, G W Schmid-Schönbein (1995) <i>J Leukoc Biol</i> <i></i> <i></i> 57: 1 20-26<br/>

http://publicationslist.org/hidekazu.suzuki/refid103 2008-03-19T11:31:05Z

To gain insight into the mechanisms responsible for muscle dysfunction after ischemia-reperfusion, a rat spinotrapezius muscle preparation was developed which enabled sequential measurements of in vivo maximum tetanic force production and cell death assessed using digital microfluorographic determination of propidium iodide (PI) staining. After 60 min of no-flow ischemia, maximum tetanic force fel...<br/><br/>H Suzuki, D C Poole, B W Zweifach, G W Schmid-Schönbein (1995) <i>J Clin Invest</i> <i></i> <i></i> 96: 6 2892-2897<br/>

http://publicationslist.org/hidekazu.suzuki/refid119 2008-03-19T11:47:08Z

M Tsuchiya, M Suematsu, H Suzuki (1994) <i>Methods Enzymol</i> <i></i> <i></i> 233: 128-140<br/>

http://publicationslist.org/hidekazu.suzuki/refid97 2008-03-19T11:29:08Z

This study was designed to investigate the effects of prostaglandin E1 on reductive stress and the subsequent oxidative cell injury in hypoperfused rat liver. The intralobular heterogeneity of hepatocellular redox state, mitochondrial dysfunction, and intracellular hydroperoxide formation were visually monitored by digital microfluorography of pyridine nucleotide autofluorescence, rhodamine 123, a...<br/><br/>H Suzuki, M Suematsu, H Ishii, S Kato, H Miki, M Mori, Y Ishimura, T Nishino, M Tsuchiya (1994) <i>J Clin Invest</i> <i></i> <i></i> 93: 1 155-164<br/>

http://publicationslist.org/hidekazu.suzuki/refid126 2008-03-19T11:51:38Z

This study was aimed to determine the mechanism by which endogenous nitric oxide suppression promotes leukocyte adhesion in vivo. The rat mesenteric microcirculation was superfused with NG-nitro-L-arginine methyl ester (L-NAME; 100 microM), and intracellular oxidant formation in several microcirculatory cellular components such as arteriolar and venular endothelium and mast cells was visually moni...<br/><br/>M Suematsu, T Tamatani, F A Delano, M Miyasaka, M Forrest, H Suzuki, G W Schmid-Schönbein (1994) <i>Am J Physiol</i> <i></i> <i></i> 266: 6 Pt 2 H2410-H2415<br/>

http://publicationslist.org/hidekazu.suzuki/refid40 2008-03-19T11:03:49Z

The study was designed to examine the changes of thymus in sulfhydryl blocker-induced colitis. We used N-ethylmaleimide (NEM) as sulfhydryl blockers. Fasted male Sprague-Dawley rats were given 3% NEM in 1% methyl cellulose into the colon. N-ethylmaleimide treatment caused severe diarrhoea with bleeding for the first 7 days. At autopsy, adhesions, colon dilatation, and single or multiple erosions a...<br/><br/>H Suzuki, T Hibi, M Oda, Y Hosoda, M Mori, S Miura, S Tanaka, M Watanabe, M Tsuchiya (1994) <i>J Gastroenterol Hepatol</i> <i></i> <i></i> 9: 6 544-550<br/>

http://publicationslist.org/hidekazu.suzuki/refid117 2008-03-19T11:47:08Z

E. coli O157:H7 produces a cytotoxin active against Vero cells that has been termed verotoxin. In this study, we demonstrated that local intraarterial injection of verotoxin induced a decrease in blood flow and an increase in hemorrhagic lesions in rat small intestine. Significant increases in the area of hemorrhagic lesions were observed at 120 min after verotoxin injection. These lesions were pr...<br/><br/>H Tashiro, S Miura, I Kurose, D Fukumura, H Suzuki, M Suematsu, M Yoshioka, M Tsuchiya, A Kai, Y Kudoh (1994) <i>Dig Dis Sci</i> <i></i> <i></i> 39: 6 1230-1238<br/>

http://publicationslist.org/hidekazu.suzuki/refid118 2008-03-19T11:47:08Z

The effects of rat CINC/gro, a member of the interleukin-8 family, on the endothelium-neutrophil interaction and transendothelial macromolecular leakage were studied in rat mesenteric microcirculation. Thirty minutes after superfusion with 10 nM CINC/gro, the number of neutrophils adherent to the venular endothelium and those migrated across the venules were significantly increased with a concomit...<br/><br/>H Suzuki, M Suematsu, S Miura, Y Y Liu, K Watanabe, M Miyasaka, S Tsurufuji, M Tsuchiya (1994) <i>J Leukoc Biol</i> <i></i> <i></i> 55: 5 652-657<br/>

http://publicationslist.org/hidekazu.suzuki/refid115 2008-03-19T11:47:08Z

The effect of rebamipide, a novel antiulcer compound, on Helicobacter pylori activated neutrophil dependent in vitro gastric epithelial cell injury was investigated. Luminol dependent chemiluminescence (ChL), which detects toxic oxidants from neutrophils exhibited a 12-fold increase when the bacterial suspension of H pylori was added to the isolated human neutrophils. This change was significantly...<br/><br/>M Suzuki, S Miura, M Mori, A Kai, H Suzuki, D Fukumura, M Suematsu, M Tsuchiya (1994) <i>Gut</i> <i></i> <i></i> 35: 10 1375-1378<br/>

http://publicationslist.org/hidekazu.suzuki/refid109 2008-03-19T11:31:05Z

Hypertension is associated with a progressive organ injury whose etiology remains largely speculative. An increasing database shows that activated leukocytes, while affording an important immune protection, may be a contributing factor to several of the pathogenetic features of the hypertension syndrome. The purpose of this study was to determine the extent to which the glucocorticoid pathway may ...<br/><br/>H Suzuki, G W Schmid-Schönbein, M Suematsu, F A DeLano, M J Forrest, M Miyasaka, B W Zweifach (1994) <i>Hypertension</i> <i></i> <i></i> 24: 6 719-727<br/>

http://publicationslist.org/hidekazu.suzuki/refid98 2008-03-19T11:29:08Z

Intralobular oxygen radical formation was examined in cerulein-stimulated rat pancreatic acinar cells by digital imaging microscopic fluorography using a hydroperoxide-sensitive fluorescent probe, dichlorofluorescin (DCFH) diacetate. The isolated pancreatic acinar cells loaded with DCFH diacetate were microscopically observed, and the dichlorofluorescein (DCF) fluorescence yielded by DCFH oxidatio...<br/><br/>H Suzuki, M Suematsu, S Miura, H Asako, I Kurose, H Ishii, S Houzawa, M Tsuchiya (1993) <i>Pancreas</i> <i></i> <i></i> 8: 4 465-470<br/>

http://publicationslist.org/hidekazu.suzuki/refid120 2008-03-19T11:47:08Z

Intralobular distribution of Ito cells (fat-storing cells) in hepatic microcirculatory units was investigated through intravital fluorescence microscopy. By using a low-level ultraviolet epi-illumination and a sensitive silicon intensified target camera, the intrahepatic autofluorescence was visualized and digitally processed. In rats fed an ordinary diet, the ultraviolet-excited autofluorescence ...<br/><br/>M Suematsu, M Oda, H Suzuki, H Kaneko, N Watanabe, T Furusho, S Masushige, M Tsuchiya (1993) <i>Microvasc Res</i> <i></i> <i></i> 46: 1 28-42<br/>

http://publicationslist.org/hidekazu.suzuki/refid100 2008-03-19T11:29:08Z

Intralobular heterogeneity of oxidative stress and its topographic relationship with cell death during low-flow hypoxia were shown in perfused rat liver by digital microfluorography using dichlorofluorescin diacetate, a fluorochrome sensitive to intracellular hydroperoxide formation, and propidium iodide, which labels the nuclei of nonviable cells. The surface of the liver loaded with two precurso...<br/><br/>M Suematsu, H Suzuki, H Ishii, S Kato, T Yanagisawa, H Asako, M Suzuki, M Tsuchiya (1992) <i>Gastroenterology</i> <i></i> <i></i> 103: 3 994-1001<br/>

http://publicationslist.org/hidekazu.suzuki/refid99 2008-03-19T11:29:08Z

BACKGROUND: Although it has been postulated that mitochondrial dysfunction and oxygen radicals may play a role in the mechanisms of hypoxic liver injury, little is known about the intralobular topographic relationship between a disorder in oxygen metabolism and cell death during hypoxia. EXPERIMENTAL DESIGN: Intralobular heterogeneity of mitochondrial dysfunction and its topographic relationship t...<br/><br/>M Suematsu, H Suzuki, H Ishii, S Kato, H Hamamatsu, S Miura, M Tsuchiya (1992) <i>Lab Invest</i> <i></i> <i></i> 67: 4 434-442<br/>

http://publicationslist.org/hidekazu.suzuki/refid121 2008-03-19T11:47:08Z

The role of neutrophil and its chlorinated oxidant were investigated in Helicobacter pylori-induced gastric mucosal injury in vitro. Luminol-dependent chemiluminescence (ChL) was used to detect neutrophil-derived oxidants. ChL activity was significantly elevated when neutrophils were incubated in H. pylori, indicating that H. pylori actually elicits oxidative burst of neutrophils. To assess whethe...<br/><br/>M Suzuki, S Miura, M Suematsu, D Fukumura, I Kurose, H Suzuki, A Kai, Y Kudoh, M Ohashi, M Tsuchiya (1992) <i>Am J Physiol</i> <i></i> <i></i> 263: 5 Pt 1 G719-G725<br/>

http://publicationslist.org/hidekazu.suzuki/refid123 2008-03-19T11:47:08Z

Rat cytokine-induced neutrophil chemoattractant (CINC) is a member of the IL-8 family, and its human counterpart is gro/MGSA but not IL-8. We ascertained that chemically synthesized CINC was comparable to native CINC/gro with regard to chemotactic activity for rat neutrophils and studied the effect of synthesized CINC/gro on circulating leukocytes in microvascular vessels of rat mesentery. Exposur...<br/><br/>K Watanabe, M Suematsu, M Iida, K Takaishi, Y Iizuka, H Suzuki, M Suzuki, M Tsuchiya, S Tsurufuji (1992) <i>Exp Mol Pathol</i> <i></i> <i></i> 56: 1 60-69<br/>

http://publicationslist.org/hidekazu.suzuki/refid122 2008-03-19T11:47:08Z

In this study, we have demonstrated that repeated electrical stimuli to the artery of the mesenteric pedicle can produce mesenteric microcirculatory disturbance by autonomic nervous irritation in rats. The parameters to demonstrate microcirculatory damage were observed and quantitatively analyzed using the intravital microscopy after electrical stimulation for 40 minutes. The blood flow of arterio...<br/><br/>Y Y Liu, S Miura, H Suzuki, I Kurose, D Fukumura, M Suzuki, M Suematsu, M Tsuchiya (1992) <i>Keio J Med</i> <i></i> <i></i> 41: 3 128-133<br/>

http://publicationslist.org/hidekazu.suzuki/refid101 2008-03-19T11:29:08Z

Spatial and temporal alterations in carbon tetrachloride-induced oxidative stress were studied in perfused hepatic microcirculatory units of the rat by digital imaging microscopic fluorography using dichlorofluorescin diacetate, a hydroperoxide-sensitive fluorogenic probe. The surface of the liver loaded with dichlorofluorescin was microscopically visualized, and the fluorescence of dichlorofluore...<br/><br/>M Suematsu, S Kato, H Ishii, H Asako, T Yanagisawa, H Suzuki, C Oshio, M Tsuchiya (1991) <i>Lab Invest</i> <i></i> <i></i> 64: 2 167-173<br/>