http://publicationslist.org/data/idoweck/atom.xml Ilana Doweckhttp://publicationslist.org/idoweck$basepathfavicon.icoRecent additions to Ilana Doweck's PublicationsList.org pagehttp://publicationslist.org/publications.png2008-07-07T19:56:11Z http://publicationslist.org/idoweck/refid7 2008-07-07T19:47:38Z

BACKGROUND: Surgery followed by radiotherapy is the standard of care for resectable locally advanced oral cavity squamous cell carcinoma (SCC). We report the treatment outcomes of patients with T3-T4 SCC of the oral cavity treated with chemoradiation, an alternative approach. PATIENTS AND METHODS: From a series of 240 patients with stage III-IV carcinoma of the upper aerodigestive tract who were t...<br/><br/>Ilana Doweck, K Thomas Robbins, Sandeep Samant, Francisco Vieira (2008) <i>World J Surg Oncol</i> <i></i> <i></i> 6: <br/>

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OBJECTIVES/HYPOTHESIS: To determine the pattern of spread of WDTC to regional lymph nodes, in patients who presented with clinically positive nodes. STUDY DESIGN: Retrospective chart review. MATERIALS AND METHODS: Between October 2001 and December 2006, a total of 27 consecutive patients (12 males, 15 females) with clinical evidence of cervical metastasis of well-differentiated thyroid carcinoma (...<br/><br/>Yoav Yanir, Ilana Doweck (2008) <i>Laryngoscope</i> <i></i> <i></i> 118: 3 433-436<br/>

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OBJECTIVES: The objectives of this study were to assess the value of F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with carcinoma of the larynx as compared with PET and CT alone and to assess the impact of PET/CT on further clinical management. STUDY DESIGN: This was a prospective, nonrandomized study. MATERIALS AND METHODS: Forty-two patients wit...<br/><br/>Arie Gordin, Marcello Daitzchman, Ilana Doweck, Nikolay Yefremov, Avishay Golz, Zohar Keidar, Rachel Bar-Shalom, Abraham Kuten, Ora Israel (2006) <i>Laryngoscope</i> <i></i> <i></i> 116: 2 273-278<br/>

http://publicationslist.org/idoweck/refid9 2008-07-07T19:47:38Z

Heparanase is an endoglycosidase that specifically cleaves heparan sulfate (HS) side chains of HS proteoglycans, the major proteoglycans in the extracellular matrix and cell surfaces. Traditionally, heparanase activity was implicated in cellular invasion associated with angiogenesis, inflammation, and cancer metastasis. More recently, heparanase upregulation was documented in an increasing number ...<br/><br/>Ilana Doweck, Victoria Kaplan-Cohen, Inna Naroditsky, Edmond Sabo, Neta Ilan, Israel Vlodavsky (2006) <i>Neoplasia</i> <i></i> <i></i> 8: 12 1055-1061<br/>

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OBJECTIVE: To determine the efficacy of selective and superselective neck dissection for patients with bulky or residual nodal metastasis treated with concomitant intra-arterial cisplatin and radiotherapy. DESIGN: Prospective study. SETTING: University of Tennessee, Memphis. PATIENTS: A total of 240 patients with stage III or IV head and neck squamous cell carcinoma. INTERVENTIONS: Treatment with ...<br/><br/>K Thomas Robbins, Ilana Doweck, Sandeep Samant, Francisco Vieira (2005) <i>Arch Otolaryngol Head Neck Surg</i> <i></i> <i></i> 131: 11 965-969<br/>

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OBJECTIVE: To assess the pattern of regional metastases from SCC of the skin of the head and neck as a prognostic factor. STUDY DESIGN AND SETTING: A retrospective chart review of 22 patients treated in a tertiary academic center. RESULTS: Metastases could be assessed clinically in the parotid gland and the neck in 50% and 59% of the patients, respectively. Histologic examination showed metastases...<br/><br/>Geva Barzilai, Elhanan Greenberg, Raanan Cohen-Kerem, Ilana Doweck (2005) <i>Otolaryngol Head Neck Surg</i> <i></i> <i></i> 132: 6 852-856<br/>

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OBJECTIVES: To determine the relative risk of prognostic factors for local disease control following RADPLAT. STUDY DESIGN: Prospective study, academic medical center. METHODS: Analyses of nine categories of risk factors among 240 patients with Stage II-IV carcinoma consecutively treated with RADPLAT (cisplatin 150 mg/m IA and sodium thiosulfate 9 g/m IV, weekly x4; radiotherapy 2 Gy/fraction/d, 5...<br/><br/>K Thomas Robbins, Ilana Doweck, Sandeep Samant, Francisco Vieira, Parvesh Kumar (2004) <i>Laryngoscope</i> <i></i> <i></i> 114: 3 411-417<br/>

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OBJECTIVE: The objective of this study was to review the subgroup classification of fungal sinusitis in immunocompetent patients. METHODS: The study design included 19 immunocompetent patients with fungal sinusitis who were operated on between 1993 and 1998. RESULTS: Ten of 19 patients showed a fungus ball. They underwent a limited surgical endoscopic procedure, and no further treatment was needed...<br/><br/>Nechama Uri, Raanan Cohen-Kerem, Irit Elmalah, Illana Doweck, Elhanan Greenberg (2003) <i>Otolaryngol Head Neck Surg</i> <i></i> <i></i> 129: 4 372-378<br/>

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BACKGROUND: Idiopathic sudden sensorineural hearing loss (ISSNHL) is a vexing problem that continues to pose a diagnostic and therapeutic enigma for the otologist. The aim of the study, adopting the viral theory, was to discover whether patients with ISSNHL would benefit from early treatment with acyclovir and hydrocortisone compared with patients treated by hydrocortisone alone. METHODS: Sixty pa...<br/><br/>Nechama Uri, Ilana Doweck, Raanan Cohen-Kerem, Elhanan Greenberg (2003) <i>Otolaryngol Head Neck Surg</i> <i></i> <i></i> 128: 4 544-549<br/>

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Ramsay Hunt syndrome is an herpetic disease with ominous prognosis regarding the facial nerve. Treatment with acyclovir, a well-known virostatic agent, has been given in a small number of patients in recent years with excellent results. We report on the administration of acyclovir intravenously for 7 days in 31 patients with Ramsay Hunt syndrome, with overall recovery rate of 82.6%. There were no ...<br/><br/>Nechama Uri, Elhanan Greenberg, Ruth Kitzes-Cohen, Ilana Doweck (2003) <i>Otolaryngol Head Neck Surg</i> <i></i> <i></i> 129: 4 379-381<br/>

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PURPOSE: To determine the extent of the required neck dissection for patients with persistent lymphadenopathy after definitive radiation therapy for oropharyngeal cancer. If feasible, a conservative approach using selective neck dissection would likely minimize the extent of neck fibrosis and other adverse sequelae. METHODS: Analysis of pretreatment and posttreatment radiologic scans and pathology...<br/><br/>Ilana Doweck, K Thomas Robbins, William M Mendenhall, Russell W Hinerman, Christopher Morris, Robert Amdur (2003) <i>Head Neck</i> <i></i> <i></i> 25: 11 960-967<br/>

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Betahistine was evaluated for the prevention of seasickness in a laboratory and sea study. The effect of 48 mg betahistine on the vestibulo-ocular reflex (VOR) and on psychomotor performance was evaluated in twelve young healthy subjects in a double-blind, placebo controlled, randomized, crossover design. The vestibulo-ocular reflex was evaluated by the Sinusoidal Harmonic Acceleration (SHA) test ...<br/><br/>Carlos R Gordon, Ilana Doweck, Zohar Nachum, Adi Gonen, Orna Spitzer, Avi Shupak (2003) <i>J Vestib Res</i> <i></i> <i></i> 13: 2-3 103-111<br/>

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The association between asthma and sinonasal disease has been known for years. Effective treatment of sinonasal disease, which is one of the factors that exacerbate asthma, may also improve and stabilize the asthmatic condition. This study examines the outcome of functional endoscopic sinus surgery (FESS) on asthmatic patients with massive nasal polyposis. Thirty-four asthmatic patients were inclu...<br/><br/>Nechama Uri, Raanan Cohen-Kerem, Geva Barzilai, Elhanan Greenberg, Ilana Doweck, Daniel Weiler-Ravell (2002) <i>J Laryngol Otol</i> <i></i> <i></i> 116: 3 185-189<br/>

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Cytokeratins (CKs) are a subgroup of intermediate filament proteins that take part in forming the cytoskeleton. The epithelial cells in different organs express distinct CKs, and this expression may be modified during malignant transformation. Here we describe the use of reverse transcriptase-polymerase chain reaction followed by Southern blotting to determine the profile of expression of CKs in b...<br/><br/>Raanan Cohen-Kerem, Nitza Lahat, Irit Elmalah, Elhanan Greenberg, Murray B Resnick, Ilana Doweck, Michal A Rahat (2002) <i>Ann Otol Rhinol Laryngol</i> <i></i> <i></i> 111: 2 149-154<br/>

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OBJECTIVES/HYPOTHESIS: Just as tumor volume is a prognostic indicator for local disease control among patients with head and neck cancer of intermediate size treated with radiation therapy, we hypothesized a similar association for patients with advanced disease treated with chemoradiation therapy. STUDY DESIGN: Retrospective analysis of primary and nodal tumor volume was correlated with prospecti...<br/><br/>Ilana Doweck, Douglas Denys, K Thomas Robbins (2002) <i>Laryngoscope</i> <i></i> <i></i> 112: 10 1742-1749<br/>

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OBJECTIVE: We report our experience over the past 12 years with recreational diving-related inner ear decompression sickness (IEDCS). STUDY DESIGN: Retrospective, consecutive case series. METHODS: Twenty-four divers, representing 29 cases of IEDCS, are presented with regard to evaluation, treatment, and follow-up. RESULTS: These 29 cases represent 26% of the severe decompression sickness (DCS) cas...<br/><br/>Z Nachum, A Shupak, O Spitzer, Z Sharoni, I Doweck, C R Gordon (2001) <i>Laryngoscope</i> <i></i> <i></i> 111: 5 851-856<br/>

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BACKGROUND: Distant metastasis (DM) is the most common mode of recurrence among patients with advanced head and neck carcinoma treated with intra-arterial cisplatin and radiotherapy (RADPLAT). OBJECTIVE: To identify which patients are at greatest risk for DM and would benefit the most from new strategies designed to treat occult metastases. METHODS: Between 1993 and 1999, 250 patients with advance...<br/><br/>I Doweck, K T Robbins, F Vieira (2001) <i>Arch Otolaryngol Head Neck Surg</i> <i></i> <i></i> 127: 11 1315-1318<br/>

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We assessed the influence of dimenhydrinate, cinnarizine and transdermal scopolamine on the ability to perform simulated naval crew tasks. The effect of single doses of dimenhydrinate, 100 mg, cinnarizine, 50 mg, and one transdermal scopolamine patch on psychomotor performance was evaluated using a double-blind, placebo-controlled, randomized, crossover design in three separate studies. A total of...<br/><br/>C R Gordon, A Gonen, Z Nachum, I Doweck, O Spitzer, A Shupak (2001) <i>J Psychopharmacol</i> <i></i> <i></i> 15: 3 167-172<br/>

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This study examines a new tumour marker, Cyfra 21-1, as a prognostic marker in predicting the survival of H&N cancer patients, and its correlation with clinical outcome during prolonged follow up of these patients. The study included 67 patients with primary detection of carcinoma of H&N. The survival of these patients was evaluated in correlation with the disease stage and Cyfra 21-1 levels at in...<br/><br/>I Doweck, M Barak, N Uri, E Greenberg (2000) <i>Br J Cancer</i> <i></i> <i></i> 83: 12 1696-1701<br/>

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Motion sickness is a complex integration of responses from multiple physiological systems. Whether the changes that occur during the time course of motion sickness are mediated by the sympathetic or parasympathetic systems is still controversial. The present study evaluates alterations in R-R variability during experimental motion sickness in motion sick and non-motion sick subjects. Ten motion si...<br/><br/>I Doweck, C R Gordon, A Shlitner, O Spitzer, A Gonen, O Binah, Y Melamed, A Shupak (1997) <i>J Auton Nerv Syst</i> <i></i> <i></i> 67: 1-2 31-37<br/>

http://publicationslist.org/idoweck/refid27 2008-07-07T19:48:41Z

Vestibular laboratory tests are not generally necessary in the diagnosis of patients with a clear description of vertigo accompanied by positive otoneurological examination findings. The purpose of the study was to investigate the role of conventional vestibular laboratory tests in the diagnosis of patients complaining of nonspecific vertigo, despite their having a documented normal otoneurologica...<br/><br/>C R Gordon, A Shupak, O Spitzer, I Doweck, Y Melamed (1996) <i>J Laryngol Otol</i> <i></i> <i></i> 110: 12 1133-1137<br/>

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VOR parameters were compared in subjects at the extremes of the seasickness susceptibility scale. Thirty-nine subjects highly susceptible to seasickness and 30 nonsusceptible subjects participated in the study. The VOR was evaluated by the Sinusoidal Harmonic Acceleration (SHA) test at frequencies of 0.01, 0.02, 0.04, 0.08, and 0.16 Hz. In subjects susceptible to seasickness, VOR gain was signific...<br/><br/>C R Gordon, O Spitzer, I Doweck, A Shupak, N Gadoth (1996) <i>J Vestib Res</i> <i></i> <i></i> 6: 4 229-233<br/>

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OBJECTIVE: Evaluation of Cyfra 21-1 (cytokeratin fraction 21-1) in squamous cell carcinoma of the head and neck. DESIGN: Prospective study. PATIENTS: Serum Cyfra 21-1 concentration was measured in 250 samples from patients with squamous cell carcinoma of head and neck, patients with benign tumors of head and neck, healthy control subjects, and patients in remission from squamous cell carcinoma of ...<br/><br/>I Doweck, M Barak, E Greenberg, N Uri, J Kellner, M Lurie, N Gruener (1995) <i>Arch Otolaryngol Head Neck Surg</i> <i></i> <i></i> 121: 2 177-181<br/>

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A survey conducted among 116 crew members of seagoing vessels confirmed that mal de debarquement (M-D) is a transient feeling of swinging, swaying, unsteadiness, and disequilibrium. None of the subjects requested medical attention, although there were isolated cases in which a strong sensation of swinging and unsteadiness caused transient postural instability and impaired the ability to drive. In ...<br/><br/>C R Gordon, O Spitzer, I Doweck, Y Melamed, A Shupak (1995) <i>J Vestib Res</i> <i></i> <i></i> 5: 5 363-369<br/>

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In a double-blind, placebo controlled, crossover study, we evaluated the effects of cinnarizine on the VOR of 55 healthy young subjects. VOR was evaluated by the Sinusoidal Harmonic Acceleration (SHA) test at frequencies of 0.01, 0.02, 0.04, 0.08 and 0.16 Hz. There was a reduction in VOR gain in 16 of the 20 SHA trials performed under the influence of cinnarizine alone (25 mg and 50 mg) and cinnar...<br/><br/>I Doweck, C R Gordon, O Spitzer, Y Melamed, A Shupak (1994) <i>J Vestib Res</i> <i></i> <i></i> 4: 3 215-220<br/>

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Cinnarizine was evaluated for the prevention of seasickness in a laboratory and sea study. The effects of 25 mg cinnarizine on the vestibulo-ocular reflex were investigated in 13 subjects. Significant reduction of the gain in response to sinusoidal oscillations at 0.02, 0.08, and 0.16 Hz (p < 0.05) and increased phase lead at 0.16 Hz (p < 0.01) were observed. The effect of 25 and 50 mg cinnarizine...<br/><br/>A Shupak, I Doweck, C R Gordon, O Spitzer (1994) <i>Clin Pharmacol Ther</i> <i></i> <i></i> 55: 6 670-680<br/>

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The present study investigates the possible relationship between motion sickness susceptibility, personality factors and salivation. Personality factors, as evaluated by the Eysenck Personality Questionnaire, and salivary composition and flow were measured in a group of 29 subjects highly susceptible to seasickness and in a group of 25 non-susceptible subjects. The non-susceptible group had signif...<br/><br/>C R Gordon, H Ben-Aryeh, O Spitzer, I Doweck, A Gonen, Y Melamed, A Shupak (1994) <i>Aviat Space Environ Med</i> <i></i> <i></i> 65: 7 610-614<br/>

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In a double-blind, placebo-controlled study, we evaluated the effect of two different doses of cinnarizine in the prevention of seasickness in very rough seas. We divided 95 healthy male subjects into 3 groups which received: cinnarizine 50 mg, cinnarizine 25 mg, and placebo. Seasickness susceptibility and severity were evaluated by a standard questionnaire concerning the subject's condition on pr...<br/><br/>I Doweck, C R Gordon, O Spitzer, Y Melamed, A Shupak (1994) <i>Aviat Space Environ Med</i> <i></i> <i></i> 65: 7 606-609<br/>

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A Shupak, I Doweck, D Nachtigal, O Spitzer, C R Gordon (1993) <i>Arch Otolaryngol Head Neck Surg</i> <i></i> <i></i> 119: 12 1362-1367<br/>

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We studied vestibulo-ocular reflex measurements in a group of 12 patients suffering from migraine without aura and evaluated the effect of sodium valproate given as prophylactic migraine therapy. The study was randomized, double blind and placebo controlled, with a crossover design. The horizontal vestibulo-ocular reflex was evaluated by the Sinusoidal Harmonic Acceleration test at 0.01, 0.02, 0.0...<br/><br/>C R Gordon, A Kuritzky, I Doweck, O Spitzer, A Shupak, R Hering (1993) <i>Headache</i> <i></i> <i></i> 33: 3 129-132<br/>

http://publicationslist.org/idoweck/refid2 2008-07-07T19:47:04Z

C R Gordon, O Spitzer, A Shupak, I Doweck (1992) <i>BMJ</i> <i></i> <i></i> 304: 6826 <br/>

http://publicationslist.org/idoweck/refid1 2008-07-07T19:47:04Z

The salivary flow rate and composition of 2 groups of 31 subjects, one group at each extreme of the seasickness susceptibility scale, were compared. No significant differences were found between the two groups in flow rates and electrolyte concentrations of whole resting and stimulated saliva. Amylase activity and rate of secretion in resting saliva were significantly higher in subjects susceptibl...<br/><br/>C R Gordon, Y Jackman, H Ben-Aryeh, I Doweck, O Spitzer, R Szargel, A Shupak (1992) <i>Aviat Space Environ Med</i> <i></i> <i></i> 63: 5 356-359<br/>

http://publicationslist.org/idoweck/refid3 2008-07-07T19:47:04Z

The currently recommended examination for diving fitness ascertains middle ear autoinflation ability only under surface pressure conditions. The purpose of our study was to document and quantify middle ear pressure equalization failure during simulated dives among diving candidates who had otherwise met the otologic criteria for diving fitness. Forty-two candidates for regular naval diving activit...<br/><br/>A Shupak, Z Sharoni, E Ostfeld, I Doweck (1991) <i>Ann Otol Rhinol Laryngol</i> <i></i> <i></i> 100: 8 658-660<br/>

http://publicationslist.org/idoweck/refid5 2008-07-07T19:47:04Z

Diving-related inner ear barotrauma (IEB) and inner ear decompression sickness (IEDS) most often result in permanent severe cochleovestibular deficits, unless immediate diagnosis is reached and the correct treatment is commenced early. Nine cases of sport-diving-induced inner ear injuries that were referred to the Israeli Naval Hyperbaric Institute between October 1987 and September 1989 are prese...<br/><br/>A Shupak, I Doweck, E Greenberg, C R Gordon, O Spitzer, Y Melamed, W S Meyer (1991) <i>Laryngoscope</i> <i></i> <i></i> 101: 2 173-179<br/>

http://publicationslist.org/idoweck/refid4 2008-07-07T19:47:04Z

A 20 year old male naval crew-member suffering from sea sickness was treated with transdermal scopolamine (TS). After 5 months of continuous treatment, he developed scopolamine intoxication followed by the appearance of recurrent classic migraine attacks. He had never suffered from headache or migraine prior to TS intoxication. The migraine attacks comprised a prodrome of apathy, bad mood and loss...<br/><br/>C R Gordon, D Mankuta, A Shupak, O Spitzer, I Doweck (1991) <i>Headache</i> <i></i> <i></i> 31: 3 172-174<br/>

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C R Gordon, A Shupak, I Doweck, O Spitzer (1989) <i>BMJ</i> <i></i> <i></i> 298: 6682 1220-1221<br/>