http://publicationslist.org/data/ikoutroub/atom.xml Ioannis Koutroubakishttp://publicationslist.org/ikoutroub$basepathfavicon.icoRecent additions to Ioannis Koutroubakis's PublicationsList.org pagehttp://publicationslist.org/publications.png2008-09-26T17:08:11Z http://publicationslist.org/ikoutroub/refid66 2008-02-20T10:09:04Z

L A Bourikas, M Tzardi, A Hatzidakis, I E Koutroubakis (2008) <i>Dig Liver Dis</i> <i></i> <i></i> 40: 2 <br/>

http://publicationslist.org/ikoutroub/refid63 2008-02-20T10:09:04Z

PURPOSE: Evaluation and comparison between pentavalent 99mTc dimercaptosuccinic acid (99mTc(V)-DMSA) and 99mTc-hexamethylpropylene amine oxime white blood cell (99mTc-HMPAO WBC) scintigraphy in the detection and assessment of disease activity in patients with active inflammatory bowel disease (IBD). MATERIALS AND METHODS: 99mTc(V)-DMSA scintigraphy was performed in 23 patients with active IBD and ...<br/><br/>Maria I Stathaki, Ioannis E Koutroubakis, Sophia I Koukouraki, Konstantinos P Karmiris, Joanna A Moschandreas, Elias A Kouroumalis, Nikolaos S Karkavitsas (2008) <i>Nucl Med Commun</i> <i></i> <i></i> 29: 1 27-32<br/>

http://publicationslist.org/ikoutroub/refid62 2008-02-20T10:09:04Z

L A Bourikas, I S Kourbeti, A V Koutsopoulos, I E Koutroubakis (2008) <i>Gut</i> <i></i> <i></i> 57: 3 425; author reply 425-425; author reply 426<br/>

http://publicationslist.org/ikoutroub/refid74 2008-09-26T17:04:50Z

BACKGROUND & AIMS: Although ischemic colitis (IC) usually occurs in old people with concomitant illnesses, an increasing frequency of this disease among young people has been reported. Inherited risk factors have been suggested to play an important role in the pathogenesis of IC. The aim of this study was to investigate the prevalence and possible role of mutations associated with cardiovascular m...<br/><br/>Angeliki Theodoropoulou, Aekaterini Sfiridaki, Pantelis Oustamanolakis, Emanouel Vardas, Aekaterini Livadiotaki, Aekaterini Boumpaki, Gregorios Paspatis, Ioannis E Koutroubakis (2008) <i>Clin Gastroenterol Hepatol</i> <i></i> <i></i> 6: 8 907-911<br/>

http://publicationslist.org/ikoutroub/refid68 2008-09-26T17:04:50Z

Inflammatory bowel disease (IBD) is characterized by anorexia, malnutrition, altered body composition, and development of mesenteric white adipose tissue (WAT) hypertrophy. Increasing evidence suggests that adipokines synthesized either in WAT or in immune cells, are involved in these manifestations of IBD. Among adipokines leptin, adiponectin and resistin hold a fundamental role while the role of...<br/><br/>Konstantinos Karmiris, Ioannis E Koutroubakis, Elias A Kouroumalis (2008) <i>Mol Nutr Food Res</i> <i></i> <i></i> 52: 8 855-866<br/>

http://publicationslist.org/ikoutroub/refid67 2008-09-26T17:04:50Z

Karimi, Crusius, Coucoutsi, Heijmans, Sambuelli, Peña, Koutroubakis (2008) <i>Inflamm Bowel Dis</i> <i></i> <i></i> : <br/>

http://publicationslist.org/ikoutroub/refid69 2008-05-11T08:58:54Z

BACKGROUND: . Angiogenesis has been suggested as an integral part of inflammatory bowel disease pathology. Vascular endothelial growth factor has long been considered to play a central, specific role in angiogenesis. Endothelial junction adhesion molecules, such as CD146, have recently been suggested to play a potent role in angiogenesis. CD34 is expressed on vascular endothelium, and it has been ...<br/><br/> Tsiolakidou, Koutroubakis, Tzardi, Kouroumalis (2008) <i>Dig Liver Dis</i> <i></i> <i></i> : <br/>

http://publicationslist.org/ikoutroub/refid71 2008-09-26T17:04:50Z

BACKGROUND: Patients with inflammatory bowel disease (IBD) have an increased risk of thromboembolic events. Imbalance of fibrinolysis has been suggested as one of the possible pathogenetic mechanisms. As plasminogen activator inhibitor-1 (PAI-1) and thrombin-activatable fibrinolysis inhibitor (TAFI) are inhibitors of fibrinolysis, we studied TAFI as well as PAI-1 plasma levels in IBD patients comp...<br/><br/>Ioannis E Koutroubakis, Aekaterini Sfiridaki, Georgia Tsiolakidou, Constantina Coucoutsi, Angeliki Theodoropoulou, Elias A Kouroumalis (2008) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 20: 9 912-916<br/>

http://publicationslist.org/ikoutroub/refid73 2008-09-26T17:04:50Z

Thromboembolism is a significant cause of morbidity and mortality in patients with inflammatory bowel disease (IBD). Recent data suggest thromboembolism as a disease-specific extraintestinal manifestation of IBD, which is developed as the result of multiple interactions between acquired and genetic risk factors. There is evidence indicating an imbalance of procoagulant, anticoagulant and fibrinoli...<br/><br/>Georgia Tsiolakidou, Ioannis-E Koutroubakis (2008) <i>World J Gastroenterol</i> <i></i> <i></i> 14: 28 4440-4444<br/>

http://publicationslist.org/ikoutroub/refid70 2008-09-26T17:04:50Z

AIM: To evaluate the role of pentavalent Tc-99m dimercaptosuccinic acid [Tc-99m (V) DMSA] in the diagnosis of ischemic colitis. METHODS: Fourteen patients with endoscopically and histologically confirmed ischemic colitis were included in the study. Tc-99m (V) DMSA scintigraphy was performed within 2 d after colonoscopy. Images were considered positive when an area of increased activity was observe...<br/><br/>Maria-I Stathaki, Ioannis-E Koutroubakis, Sophia-I Koukouraki, Elias-A Kouroumalis, Nikolaos-S Karkavitsas (2008) <i>World J Gastroenterol</i> <i></i> <i></i> 14: 35 5432-5435<br/>

http://publicationslist.org/ikoutroub/refid72 2008-09-26T17:04:50Z

There is evidence that thromboembolism as a disease-specific extraintestinal manifestation of inflammatory bowel disease (IBD) is developed as the result of multiple interactions between acquired and genetic risk factors. An imbalance of procoagulant, anticoagulant, and fibrinolitic factors predisposing to thrombosis has been reported by several studies in patients with IBD. The study by Nguyen an...<br/><br/> Koutroubakis (2008) <i>Am J Gastroenterol</i> <i></i> <i></i> : <br/>

http://publicationslist.org/ikoutroub/refid3 2007-09-22T16:14:56Z

The management of patients with persistent perianal fistulae depends on thorough evaluation by clinical history and examination, assessment of intestinal disease and assessment of perianal disease. The main therapeutic options are medical and surgical treatment and their appropriate integration is essential for the optimal management of the patients. Medical treatment includes antibiotics, azathio...<br/><br/>Ioannis E Koutroubakis (2007) <i>Best Pract Res Clin Gastroenterol</i> <i></i> <i></i> 21: 3 503-518<br/>

http://publicationslist.org/ikoutroub/refid4 2007-09-22T16:14:56Z

Ioannis E Koutroubakis, Konstantinos Karmiris, Leonidas Bourikas, Elias A Kouroumalis, Ioannis Drygiannakis, Dimitrios Drygiannakis (2007) <i>Inflamm Bowel Dis</i> <i></i> <i></i> 13: 4 504-505<br/>

http://publicationslist.org/ikoutroub/refid2 2007-09-22T16:14:56Z

BACKGROUND: Tumour necrosis factor alpha is a critical mediator of inflammation-related altered metabolism in inflammatory bowel disease (IBD), possibly through its interaction with adipokines, which play an important role in IBD. Infliximab is a well established antitumour necrosis factor alpha treatment in IBD. AIM AND METHODS: We studied serum levels of leptin, adiponectin and resistin in 20 IB...<br/><br/>Konstantinos Karmiris, Ioannis E Koutroubakis, Costas Xidakis, Maria Polychronaki, Elias A Kouroumalis (2007) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 19: 9 789-794<br/>

http://publicationslist.org/ikoutroub/refid5 2007-09-22T16:14:56Z

BACKGROUND: Inherited risk factors have been suggested to play an important role in the pathogenesis of vascular complications of inflammatory bowel disease (IBD). The aim of the present study was to investigate the role of mutations associated with cardiovascular disease in IBD patients with or without vascular complications compared with thrombotic and healthy controls (HC). METHODS: Twelve poly...<br/><br/>I E Koutroubakis, A Sfiridaki, G Tsiolakidou, A Theodoropoulou, A Livadiotaki, G Paspatis, E A Kouroumalis (2007) <i>Inflamm Bowel Dis</i> <i></i> <i></i> 13: 4 410-415<br/>

http://publicationslist.org/ikoutroub/refid64 2008-02-20T10:09:04Z

The researchers' view regarding the role of white adipose tissue (WAT) in inflammation has been greatly transformed over the last 10 years. WAT is now considered as an active organ producing many crucial molecules called adipokines. Resistin is a recently discovered cysteine-rich adipokine that has emerged during this decade as a promising inflammatory marker in various diseases. It is synthesized...<br/><br/>Konstantinos Karmiris, Ioannis E Koutroubakis (2007) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 19: 12 1035-1037<br/>

http://publicationslist.org/ikoutroub/refid1 2007-09-22T16:14:56Z

Anemia is a frequent complication in patients with inflammatory bowel disease (IBD), and is associated with decreased quality of life and increased rate of hospitalization. The primary therapeutic targets of IBD-associated anemia are iron deficiency and anemia of chronic disease. An important prognostic parameter of the success or failure of therapy is the outcome of the underlying disease. Iron d...<br/><br/>Georgia Tsiolakidou, Ioannis-E Koutroubakis (2007) <i>World J Gastroenterol</i> <i></i> <i></i> 13: 36 4798-4806<br/>

http://publicationslist.org/ikoutroub/refid65 2008-02-20T10:09:04Z

Anemia is a common complication of inflammatory bowel diseases. An international working party has formed and developed guidelines for evaluation and treatment of anemia and iron deficiency that should serve practicing gastroenterologists. Within a total of 16 statements, recommendations are made regarding diagnostic measures to screen for iron- and other anemia-related deficiencies regarding the ...<br/><br/>Christoph Gasche, Arnold Berstad, Ragnar Befrits, Christoph Beglinger, Axel Dignass, Kari Erichsen, Fernando Gomollon, Henrik Hjortswang, Ioannis Koutroubakis, Stefanie Kulnigg, Bas Oldenburg, David Rampton, Oliver Schroeder, Jürgen Stein, Simon Travis, Gert Van Assche (2007) <i>Inflamm Bowel Dis</i> <i></i> <i></i> 13: 12 1545-1553<br/>

http://publicationslist.org/ikoutroub/refid11 2007-09-22T16:23:20Z

BACKGROUND: There is evidence that adipocytokines play an important role in metabolism and in inflammation. Because human metabolism dramatically changes in inflammatory bowel disease (IBD) and chronic inflammation is the hallmark of the disease, we studied serum levels of leptin, adiponectin, resistin, and ghrelin in patients with ulcerative colitis (UC) and Crohn's disease (CD) in comparison wit...<br/><br/>Konstantinos Karmiris, Ioannis E Koutroubakis, Costas Xidakis, Maria Polychronaki, Theodora Voudouri, Elias A Kouroumalis (2006) <i>Inflamm Bowel Dis</i> <i></i> <i></i> 12: 2 100-105<br/>

http://publicationslist.org/ikoutroub/refid13 2007-09-22T16:23:20Z

BACKGROUND: In Crohn's disease (CD), studies associating phenotype at diagnosis and subsequent disease activity are important for patient counselling and health care planning. AIMS: To calculate disease recurrence rates and to correlate these with phenotypic traits at diagnosis. METHODS: A prospectively assembled uniformly diagnosed European population based inception cohort of CD patients was cla...<br/><br/>F L Wolters, M G Russel, J Sijbrandij, T Ambergen, S Odes, L Riis, E Langholz, P Politi, A Qasim, I Koutroubakis, E Tsianos, S Vermeire, J Freitas, G van Zeijl, O Hoie, T Bernklev, M Beltrami, D Rodriguez, R W Stockbrügger, B Moum (2006) <i>Gut</i> <i></i> <i></i> 55: 8 1124-1130<br/>

http://publicationslist.org/ikoutroub/refid9 2007-09-22T16:14:56Z

Ioannis E Koutroubakis, Georgia Tsiolakidou, Elias A Kouroumalis (2006) <i>Am J Gastroenterol</i> <i></i> <i></i> 101: 2 403; author reply 403-403; author reply 404<br/>

http://publicationslist.org/ikoutroub/refid10 2007-09-22T16:14:56Z

BACKGROUND: Angiogenesis has been suggested to play an important role in inflammatory bowel disease (IBD). The aim of the study was to evaluate the serum markers of angiogenesis angiopoietin-2 (Ang-2) and soluble angiopoietin receptor Tie-2 in patients with ulcerative colitis (UC) and Crohn's disease (CD). MATERIALS AND METHODS: Serum Ang-2 and Tie-2 serum levels were measured in 160 IBD patients ...<br/><br/>I E Koutroubakis, C Xidakis, K Karmiris, A Sfiridaki, E Kandidaki, E A Kouroumalis (2006) <i>Eur J Clin Invest</i> <i></i> <i></i> 36: 2 127-132<br/>

http://publicationslist.org/ikoutroub/refid8 2007-09-22T16:14:56Z

BACKGROUND: The combination of intravenous iron and recombinant human erythropoietin has been proved to be effective in the treatment of refractory anaemia in patients with inflammatory bowel disease (IBD). Darbepoetin-alpha (DPO) has a three-fold longer terminal half-life than erythropoietin. The purpose of this pilot study was to determine whether darbepoetin-alpha is also effective for the trea...<br/><br/>Ioannis E Koutroubakis, Konstantinos Karmiris, Sokratis Makreas, Costas Xidakis, Maria Niniraki, Elias A Kouroumalis (2006) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 18: 4 421-425<br/>

http://publicationslist.org/ikoutroub/refid7 2007-09-22T16:14:56Z

I E Koutroubakis, K Karmiris, E A Kouroumalis (2006) <i>Aliment Pharmacol Ther</i> <i></i> <i></i> 23: 8 1273-4; author reply 1274-5<br/>

http://publicationslist.org/ikoutroub/refid6 2007-09-22T16:14:56Z

Several studies have shown alterations in vascular anatomy and physiology in inflammatory bowel disease (IBD). These findings, together with the observed upregulation of the mediators of angiogenesis in IBD patients, suggest that angiogenesis possibly contributes to the initiation and perpetuation of IBD. There is considerable evidence of an interrelationship between the mechanisms of angiogenesis...<br/><br/>Ioannis E Koutroubakis, Georgia Tsiolakidou, Konstantinos Karmiris, Elias A Kouroumalis (2006) <i>Inflamm Bowel Dis</i> <i></i> <i></i> 12: 6 515-523<br/>

http://publicationslist.org/ikoutroub/refid61 2007-09-22T16:37:18Z

The purpose of this study was to compare MR enteroclysis (MRE) with conventional enteroclysis (CE) in patients with small intestinal Crohn's disease. Fifty-two consecutive patients with known or suspected Crohn's disease underwent MR and conventional enteroclysis, which was considered the gold standard. Eleven imaging features, classified in three groups, mucosal, transmural and extraintestinal, w...<br/><br/>Nicholas C Gourtsoyiannis, John Grammatikakis, George Papamastorakis, John Koutroumbakis, Panos Prassopoulos, Maria Rousomoustakaki, Nickolas Papanikolaou (2006) <i>Eur Radiol</i> 16: 9 1915-1925<br/>

http://publicationslist.org/ikoutroub/refid15 2007-09-22T16:23:20Z

Anorexia, malnutrition, altered body composition and development of mesenteric obesity are well known features of inflammatory bowel disease (IBD). Recent data suggest that dysregulation of protein secretion by white adipose tissue is involved in these manifestations of patients with IBD. Adipocytes are recently recognized as endocrine cells that secrete a variety of bioactive substances known as ...<br/><br/>Konstantinos Karmiris, Ioannis E Koutroubakis, Elias A Kouroumalis (2005) <i>Inflamm Bowel Dis</i> <i></i> <i></i> 11: 9 847-855<br/>

http://publicationslist.org/ikoutroub/refid14 2007-09-22T16:23:20Z

Inflammatory bowel disease (IBD) is associated with an increased risk of vascular complications. The most important of these complications are arterial and venous thromboembolism, which represent a significant cause of morbidity and mortality in IBD patients. Recent data suggest that thromboembolism is a disease-specific extraintestinal manifestation of IBD. The most common thrombotic manifestatio...<br/><br/>Ioannis E Koutroubakis (2005) <i>Nat Clin Pract Gastroenterol Hepatol</i> <i></i> <i></i> 2: 6 266-272<br/>

http://publicationslist.org/ikoutroub/refid12 2007-09-22T16:23:20Z

Pancreatic autoantibodies (PAbs) have been suggested as a specific but not sensitive marker for Crohn's disease (CD). The aim of this study was to assess the value of detecting PAbs in Greek patients with ulcerative colitis (UC) and CD. Sera were collected from 150 patients with IBD (73 with UC and 77 with CD), 31 cases with non-IBD intestinal inflammation, 16 cases with other autoimmune diseases,...<br/><br/>Ioannis E Koutroubakis, Dimitrios Drygiannakis, Konstantinos Karmiris, Ioannis Drygiannakis, Sokratis Makreas, Elias A Kouroumalis (2005) <i>Dig Dis Sci</i> <i></i> <i></i> 50: 12 2330-2334<br/>

http://publicationslist.org/ikoutroub/refid19 2007-09-22T16:23:20Z

BACKGROUND: Segmental colitis associated with diverticulosis (SCAD) has been defined as chronic colonic inflammation surrounding diverticula with rectal sparing. Distinguishing this condition from inflammatory bowel disease may be difficult. Our aim was to evaluate the epidemiological and clinical characteristics of SCAD in our area. METHODS: Retrospective case identification with prospective foll...<br/><br/>I E Koutroubakis, P Antoniou, M Tzardi, E A Kouroumalis (2005) <i>Int J Colorectal Dis</i> <i></i> <i></i> 20: 1 28-32<br/>

http://publicationslist.org/ikoutroub/refid20 2007-09-22T16:23:20Z

Hepatocellular carcinoma (HCC) patients have an increased risk for venous thromboembolism, mainly portal venous thrombosis (PVT). The aim of this study was to assess the role of acquired and hereditary thrombotic risk factors in HCC patients. Thirty-one patients with HCC, 30 patients with cirrhosis but without HCC or PVT, and 48 matched healthy controls were studied. Mean levels of plasma protein ...<br/><br/>Demetrios N Samonakis, Ioannis E Koutroubakis, Aekaterini Sfiridaki, Niki Malliaraki, Pavlos Antoniou, John Romanos, Elias A Kouroumalis (2004) <i>Dig Dis Sci</i> <i></i> <i></i> 49: 5 854-858<br/>

http://publicationslist.org/ikoutroub/refid21 2007-09-22T16:26:56Z

Angeliki Theodoropoulou, Ioannis E Koutroubakis, Elias A Kouroumalis (2004) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 16: 4 431-432<br/>

http://publicationslist.org/ikoutroub/refid18 2007-09-22T16:23:20Z

Oxidative stress and depletion of antioxidants may play a key role in the pathogenesis of inflammatory bowel disease (IBD)-related intestinal damage. A new automated assay for the determination of blood total antioxidant capacity (TAC), based on the crocin bleaching method, has been used for the measurement of TAC and corrected TAC (cTAC) in patients with ulcerative colitis (UC) and Crohn's diseas...<br/><br/>Ioannis E Koutroubakis, Niki Malliaraki, Philippos D Dimoulios, Konstantinos Karmiris, Elias Castanas, Elias A Kouroumalis (2004) <i>Dig Dis Sci</i> <i></i> <i></i> 49: 9 1433-1437<br/>

http://publicationslist.org/ikoutroub/refid16 2007-09-22T16:23:20Z

Angiogenesis-promoting cytokines have been suggested to play an important role in inflammatory bowel disease (IBD) since they promote inflammation by increasing vascular permeability and mediate tissue repair by activating fibroblasts. The aim of the present study was to evaluate the serum levels of angiogenin, a potent angiogenic factor, in patients with ulcerative colitis (UC) and Crohn's diseas...<br/><br/>Ioannis E Koutroubakis, Costas Xidakis, Konstantinos Karmiris, Aekaterini Sfiridaki, Ermioni Kandidaki, Elias A Kouroumalis (2004) <i>Dig Dis Sci</i> <i></i> <i></i> 49: 11-12 1758-1762<br/>

http://publicationslist.org/ikoutroub/refid17 2007-09-22T16:23:20Z

BACKGROUND: Inflammatory bowel disease is associated with an increased incidence of thromboembolic complications. The aim of this study was to investigate the role of the soluble CD40 ligand (sCD40L), which displays prothrombotic properties, in patients with ulcerative colitis (UC) and Crohn's disease (CD) in comparison with inflammatory and healthy controls. METHODS: Plasma levels of sCD40L, prot...<br/><br/>Ioannis E Koutroubakis, Angeliki Theodoropoulou, Costas Xidakis, Aekaterini Sfiridaki, George Notas, George Kolios, Elias A Kouroumalis (2004) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 16: 11 1147-1152<br/>

http://publicationslist.org/ikoutroub/refid28 2007-09-22T16:26:56Z

Maria Roussomoustakaki, Ioannis Koutroubakis, Em Manouel Vardas, Philippos Dimoulios, Elias A Kouroumalis, Stavroula Baritaki, George Koutsoudakis, Elias Krambovitis (2003) <i>Gastroenterology</i> <i></i> <i></i> 124: 1 272-3; author reply 273-4<br/>

http://publicationslist.org/ikoutroub/refid27 2007-09-22T16:26:56Z

BACKGROUND AND AIMS: Initiation of a fibrotic process has been suggested as part of the intestinal response to chronic inflammation in inflammatory bowel disease. YKL-40 has been proposed as a new serum marker of fibrosis. We studied compared the serum levels of YKL-40 in patients with ulcerative colitis or Crohn's disease with inflammatory and healthy controls. PATIENTS AND METHODS: YKL-40 serum ...<br/><br/>Ioannis E Koutroubakis, Efthymia Petinaki, Philippos Dimoulios, Emmanouel Vardas, Maria Roussomoustakaki, Antonios N Maniatis, Elias A Kouroumalis (2003) <i>Int J Colorectal Dis</i> <i></i> <i></i> 18: 3 254-259<br/>

http://publicationslist.org/ikoutroub/refid24 2007-09-22T16:26:56Z

PURPOSE: To evaluate the use of pentavalent (V) technetium 99m (99mTc) dimercaptosuccinic acid (DMSA) scintigraphy for the assessment of disease activity in patients with inflammatory bowel disease (IBD). MATERIALS AND METHODS: 99mTc (V) DMSA scintigraphy was performed in 76 patients. There were 36 patients with active IBD (11 with ulcerative colitis, 25 with Crohn disease), 28 patients with inact...<br/><br/>Ioannis E Koutroubakis, Sophia I Koukouraki, Philippos D Dimoulios, Antigoni A Velidaki, Nikolaos S Karkavitsas, Elias A Kouroumalis (2003) <i>Radiology</i> <i></i> <i></i> 229: 1 70-74<br/>

http://publicationslist.org/ikoutroub/refid25 2007-09-22T16:26:56Z

BACKGROUND: Although endometriosis with sigmoid serosal involvement is not uncommon in women of childbearing age, the mucosal involvement is rare and differential diagnosis from colon cancer may be difficult due to the lack of pathognomonic symptoms and the poor diagnostic yield of colonoscopy and colonic biopsies. CASE PRESENTATION: We present a case of a young woman with sigmoid endometriosis, i...<br/><br/>Philippos Dimoulios, Ioannis E Koutroubakis, Maria Tzardi, Pavlos Antoniou, Ioannis M Matalliotakis, Elias A Kouroumalis (2003) <i>BMC Gastroenterol</i> <i></i> <i></i> 3: <br/>

http://publicationslist.org/ikoutroub/refid23 2007-09-22T16:26:56Z

Hypercoagulable states have been suggested to play an important role in the pathogenesis of ischemic colitis. Since protein Z is, as recently demonstrated, important in the regulation of coagulation, we investigated the plasma levels of protein Z in connection to factor V Leiden (FVL) and anti-phospholipid antibodies in patients with a definite diagnosis of ischemic colitis. The plasma levels of p...<br/><br/>Ioannis E Koutroubakis, Angeliki Theodoropoulou, Aekaterini Sfiridaki, Elias A Kouroumalis (2003) <i>Dig Dis Sci</i> <i></i> <i></i> 48: 9 1673-1676<br/>

http://publicationslist.org/ikoutroub/refid26 2007-09-22T16:26:56Z

I E Koutroubakis, A Theodoropoulou, E A Kouroumalis (2003) <i>Gut</i> <i></i> <i></i> 52: 7 1072-1073<br/>

http://publicationslist.org/ikoutroub/refid22 2007-09-22T16:26:56Z

BACKGROUND:/Aims: Laminin and collagen IV have been proposed as extracellular matrix serum markers. Because fibrosis is a major complication of inflammatory bowel disease, serum concentrations of laminin and collagen IV were measured in patients with ulcerative colitis (UC) and Crohn's disease (CD) and compared with inflammatory and healthy controls. METHODS: Laminin and collagen IV serum concentr...<br/><br/>I E Koutroubakis, E Petinaki, P Dimoulios, E Vardas, M Roussomoustakaki, A N Maniatis, E A Kouroumalis (2003) <i>J Clin Pathol</i> <i></i> <i></i> 56: 11 817-820<br/>

http://publicationslist.org/ikoutroub/refid29 2007-09-22T16:26:56Z

OBJECTIVES: To study the frequency and specificity of acquired coagulation inhibitors in inflammatory and malignant gastrointestinal diseases. METHODS: In a 10-year period, 511 patients from the island of Crete in Greece were studied, 302 with ulcerative colitis, 112 with Crohn's disease, 82 with gastrointestinal carcinoma and 15 with gastrointestinal lymphoma. Prothrombin time and activated parti...<br/><br/>Despina S Kyriakou, Michael G Alexandrakis, Freda H Passam, Kalliopi Foundouli, Emmanouel Matalliotakis, Ioannis E Koutroubakis, Taxiarchis V Kourelis, George Chalkiadakis, Orestis N Manoussos (2002) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 14: 12 1383-1387<br/>

http://publicationslist.org/ikoutroub/refid30 2007-09-22T16:26:56Z

Andreas N Kapsoritakis, Ioannis E Koutroubakis, Elias A Kouroumalis, Sophia I Koukouraki, Nikolaos Karkavitsas (2002) <i>Eur J Nucl Med Mol Imaging</i> <i></i> <i></i> 29: 8 <br/>

http://publicationslist.org/ikoutroub/refid31 2007-09-22T16:28:55Z

Besides a genetic predisposition, a causal role of various environmental factors has been considered in the etiology of ulcerative colitis (UC). The association between appendectomy and UC has recently been the subject of intense scrutiny in the hope that it may lead to the identification of important pathogenetic mechanisms. Published data from animal models of colitis demonstrated reduction in e...<br/><br/>Ioannis E Koutroubakis, Ioannis G Vlachonikolis, Elias A Kouroumalis (2002) <i>Inflamm Bowel Dis</i> <i></i> <i></i> 8: 4 277-286<br/>

http://publicationslist.org/ikoutroub/refid34 2007-09-22T16:28:56Z

Philippos Dimoulios, Ioannis E Koutroubakis, Aekaterini Sfiridaki, Angeliki Theodoropoulou, Elias A Kouroumalis (2002) <i>Am J Gastroenterol</i> <i></i> <i></i> 97: 3 768-769<br/>

http://publicationslist.org/ikoutroub/refid33 2007-09-22T16:28:56Z

OBJECTIVE: A dysregulated local immune defence with a constant influx of leucocytes provides a basis for continuous intestinal inflammation in ulcerative colitis and Crohn's disease. Since vascular adhesion protein 1 (VAP-1) is one of the adhesion molecules that mediates lymphocyte binding to endothelium, we investigated the levels of soluble VAP-1 (sVAP-1) in the sera of inflammatory bowel diseas...<br/><br/>Ioannis E Koutroubakis, Efthymia Petinaki, Emmanouel Vardas, Philippos Dimoulios, Maria Roussomoustakaki, Antonios N Maniatis, Elias A Kouroumalis (2002) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 14: 4 405-408<br/>

http://publicationslist.org/ikoutroub/refid32 2007-09-22T16:28:56Z

BACKGROUND: Intestinal tuberculosis is a rare disease in western countries, affecting mainly immigrants and immunocompromised patients. Intestinal tuberculosis is a diagnostic challenge, especially when active pulmonary infection is absent. It may mimic many other abdominal diseases. CASE PRESENTATION: Here, we report a case of isolated colonic tuberculosis where the initial diagnostic workup was ...<br/><br/>Constantinos Chatzicostas, Ioannis E Koutroubakis, Maria Tzardi, Maria Roussomoustakaki, Panagiotis Prassopoulos, Elias A Kouroumalis (2002) <i>BMC Gastroenterol</i> <i></i> <i></i> 2: <br/>

http://publicationslist.org/ikoutroub/refid38 2007-09-22T16:28:56Z

I G Vlachonikolis, I E Koutroubakis, O N Manousos (2001) <i>Scand J Gastroenterol</i> <i></i> <i></i> 36: 9 <br/>

http://publicationslist.org/ikoutroub/refid35 2007-09-22T16:28:56Z

The objective of this study was to measure the concentrations of tumor necrosis factor-alpha (TNFalpha) in pleural and peritoneal effusions of different causes and to verify whether TNFalpha, alpha-1-antitrypsin (alpha1AT), and complement factors C3 and C4 can be used in the differential diagnosis of serous effusion. One hundred forty-five serous effusions of various origins were analyzed. TNFalph...<br/><br/>M G Alexandrakis, D Kyriakou, I E Koutroubakis, R Alexandraki, I G Vlachonikolis, G D Eliopoulos (2001) <i>Am J Clin Oncol</i> <i></i> <i></i> 24: 6 562-565<br/>

http://publicationslist.org/ikoutroub/refid43 2007-09-22T16:32:43Z

OBJECTIVES: The combined measurement of perinuclear antineutrophil cytoplasmic autoantibodies (pANCA) and anti-Saccharomyces cerevisiae mannan antibodies (ASCA) has recently been suggested as a valuable diagnostic approach in inflammatory bowel disease (IBD). The aim of this study was to assess the value of detecting pANCA and ASCA in the differentiation between ulcerative colitis (UC) and Crohn's...<br/><br/>I E Koutroubakis, E Petinaki, I A Mouzas, I G Vlachonikolis, E Anagnostopoulou, E Castanas, A N Maniatis, E A Kouroumalis (2001) <i>Am J Gastroenterol</i> <i></i> <i></i> 96: 2 449-454<br/>

http://publicationslist.org/ikoutroub/refid39 2007-09-22T16:28:56Z

I E Koutroubakis (2001) <i>Am J Gastroenterol</i> <i></i> <i></i> 96: 5 1325-1327<br/>

http://publicationslist.org/ikoutroub/refid40 2007-09-22T16:28:56Z

OBJECTIVES: We investigated whether the mean platelet volume would be a useful marker in the evaluation of inflammatory bowel disease activity. METHODS: Complete blood count, C-reactive protein, erythrocyte sedimentation rate, serum thrombopoietin and erythropoietin, plasma beta-thromboglobulin, and platelet factor 4 were measured in 93 patients with ulcerative colitis, 66 patients with Crohn's di...<br/><br/>A N Kapsoritakis, M I Koukourakis, A Sfiridaki, S P Potamianos, M G Kosmadaki, I E Koutroubakis, E A Kouroumalis (2001) <i>Am J Gastroenterol</i> <i></i> <i></i> 96: 3 776-781<br/>

http://publicationslist.org/ikoutroub/refid36 2007-09-22T16:28:56Z

OBJECTIVE: Lipoprotein (a) is recognized as a risk factor for arterial and venous thrombosis, a property that might be related to its structural similarity to plasminogen. Since patients with inflammatory bowel disease frequently suffer from thromboembolic events, we studied the role of lipoprotein (a) in conjunction with lipids and apolipoproteins in Greek patients with ulcerative colitis and Cro...<br/><br/>I E Koutroubakis, N Malliaraki, E Vardas, E Ganotakis, A N Margioris, O N Manousos, E A Kouroumalis (2001) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 13: 12 1415-1419<br/>

http://publicationslist.org/ikoutroub/refid37 2007-09-22T16:28:56Z

BACKGROUND & AIMS: Hypercoagulable states may play an important role in the pathogenesis of colon ischemia. Aim of this study was to assess this hypothesis investigating the role of acquired and hereditary thrombotic risk factors in patients with definite diagnosis of colon ischemia. METHODS: We compared the frequency of antiphospholipid antibodies, protein C, protein S, and antithrombin deficienc...<br/><br/>I E Koutroubakis, A Sfiridaki, A Theodoropoulou, E A Kouroumalis (2001) <i>Gastroenterology</i> <i></i> <i></i> 121: 3 561-565<br/>

http://publicationslist.org/ikoutroub/refid46 2007-09-22T16:32:43Z

OBJECTIVE: Patients with inflammatory bowel disease (IBD) frequently suffer from thromboembolic events. A recently identified mechanism for thrombophilia, the poor anticoagulant response to activated protein C, has been suggested as one of the leading risk factors for thrombosis. The aim of this study was to evaluate the frequency of thrombophilic abnormalities, including activated protein C-resis...<br/><br/>I E Koutroubakis, A Sfiridaki, I A Mouzas, A Maladaki, A Kapsoritakis, M Roussomoustakaki, E A Kouroumalis, O N Manousos (2000) <i>Am J Gastroenterol</i> <i></i> <i></i> 95: 1 190-194<br/>

http://publicationslist.org/ikoutroub/refid47 2007-09-22T16:32:43Z

OBJECTIVE: Numerous epidemiological studies have been performed to determine risk factors that might contribute to the development of ulcerative colitis (UC). Recent studies have focused on the role of appendectomy in the disease's pathogenesis. This report aims to review and analyze the degree of evidence from recent published studies. METHODS: Medline and Embase databases were scrutinized for st...<br/><br/>I E Koutroubakis, I G Vlachonikolis (2000) <i>Am J Gastroenterol</i> <i></i> <i></i> 95: 1 171-176<br/>

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Idiopathic fibrosing pancreatitis is an uncommon condition in children and adolescents of unknown aetiology. This syndrome has been reported in 36 cases so far. To our knowledge none of these cases was definitively associated with Crohn's disease. In this report we describe a young female patient who developed Crohn's disease of the colon 5 years after having been diagnosed with idiopathic fibrosi...<br/><br/>S Potamianos, I E Koutroubakis, C Chatzicostas, K Rolles, A K Burroughs, E A Kouroumalis (2000) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 12: 9 1021-1024<br/>

http://publicationslist.org/ikoutroub/refid42 2007-09-22T16:32:43Z

In recent years hyperhomocysteinemia has been established as a new risk factor for arterial and venous thrombosis. Since patients with inflammatory bowel disease (IBD) frequently suffer from thromboembolic events, we studied the prevalence and clinical significance of hyperhomocysteinemia in Greek patients with ulcerative colitis (UC) and Crohn's disease (CD). In 108 consecutive fasting IBD patien...<br/><br/>I E Koutroubakis, E Dilaveraki, I G Vlachonikolis, E Vardas, G Vrentzos, E Ganotakis, I A Mouzas, A Gravanis, D Emmanouel, E A Kouroumalis (2000) <i>Dig Dis Sci</i> <i></i> <i></i> 45: 12 2347-2351<br/>

http://publicationslist.org/ikoutroub/refid44 2007-09-22T16:32:43Z

OBJECTIVES: Elevated platelet count is a well recognized marker of inflammatory bowel disease (IBD) activity. Thrombopoietin (TPO) is a critical cytokine in the physiological regulation of thrombopoiesis. The aim of this study was to investigate the serum levels of endogenous TPO in patients with IBD, the relationship between platelet counts and TPO levels, and the correlation of TPO with the clin...<br/><br/>A N Kapsoritakis, S P Potamianos, A I Sfiridaki, M I Koukourakis, I E Koutroubakis, M I Roussomoustakaki, O N Manousos, E A Kouroumalis (2000) <i>Am J Gastroenterol</i> <i></i> <i></i> 95: 12 3478-3481<br/>

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Thromboembolic disease is a significant cause of morbidity and mortality in patients with inflammatory bowel disease (IBD). It is recognized that a hypercoagulable state exists in IBD which involves all components of the clotting system. It has been suggested that this hypercoagulable state is closely linked to the disease pathogenesis. Recent studies have shown that genetic defects such as factor...<br/><br/>I E Koutroubakis (2000) <i>Dig Dis</i> <i></i> <i></i> 18: 3 161-167<br/>

http://publicationslist.org/ikoutroub/refid49 2007-09-22T16:32:43Z

PURPOSE: Appendectomy has been suggested as a possible protective factor in ulcerative colitis and as a risk factor in Crohn's disease. Tonsillectomy has also been associated with Crohn's disease. We performed a case-controlled study to investigate these associations in a homogeneous Greek population. METHODS: One hundred thirty-four consecutive cases of ulcerative colitis and 76 cases of Crohn's ...<br/><br/>I E Koutroubakis, I G Vlachonikolis, A Kapsoritakis, S Spanoudakis, M Roussomoustakaki, I A Mouzas, E A Kouroumalis, O N Manousos (1999) <i>Dis Colon Rectum</i> <i></i> <i></i> 42: 2 225-230<br/>

http://publicationslist.org/ikoutroub/refid48 2007-09-22T16:32:43Z

Primary biliary cirrhosis and ulcerative colitis are two diseases with many features of autoimmunity. Thirteen cases of coexistence of the two diseases have been reported in the literature so far. Patients are usually younger and more often males than the ordinary primary biliary cirrhosis patient, while the colitis is mild and easily controllable. In a homogeneous population of 550,000 inhabitant...<br/><br/>M Koulentaki, I E Koutroubakis, E Petinaki, M Tzardi, H Oekonomaki, I Mouzas, E A Kouroumalis (1999) <i>Dig Dis Sci</i> <i></i> <i></i> 44: 10 1953-1956<br/>

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OBJECTIVES: To investigate the effect of somatostatin in acute severe bleeding from portal hypertensive gastropathy in 26 cirrhotic patients. METHODS: All patients with signs of acute gastrointestinal bleeding and an upper GI endoscopy (during the first 24 h) indicating overt bleeding from portal hypertensive gastropathy were included in the study. Somatostatin (or the synthetic tetradecapeptide, ...<br/><br/>E A Kouroumalis, I E Koutroubakis, O N Manousos (1998) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 10: 6 509-512<br/>

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BACKGROUND: Common aetiopathogenic factors may explain the association of ulcerative colitis with autoimmune disorders such as systemic lupus erythematosus. PATIENTS: We report two cases of ulcerative colitis associated with idiopathic systemic lupus erythematosus: one patient who developed ulcerative colitis 11 years after having been diagnosed as a case of systemic lupus erythematosus and one ca...<br/><br/>I E Koutroubakis, H Kritikos, I A Mouzas, S M Spanoudakis, A N Kapsoritakis, E Petinaki, E A Kouroumalis, O N Manousos (1998) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 10: 5 437-439<br/>

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Patients with ulcerative colitis have an increased risk for developing colon cancer compared to the general population. The risk is related to the extension of the disease and its duration. This risk is the same for Crohn's colitis patients of equal extension and duration. By chemoprevention we mean the use of specific natural or synthetic chemical agents to reverse, suppress or prevent progressio...<br/><br/>I A Mouzas, E Papavassiliou, I Koutroubakis (1998) <i>Ital J Gastroenterol Hepatol</i> <i></i> <i></i> 30: 4 421-425<br/>

http://publicationslist.org/ikoutroub/refid51 2007-09-22T16:34:37Z

Patients with inflammatory bowel disease (IBD) frequently suffer from thromboembolic events. Anti-cardiolipin (aCL) antibodies have been shown to be associated with thrombosis. Recently, the antibodies against the anti-cardiolipin cofactor beta2-glycoprotein I (a(beta2)GPI) have been found with higher specificity for thrombosis. The presence of these antibodies was assessed in 128 patients with IB...<br/><br/>I E Koutroubakis, E Petinaki, E Anagnostopoulou, H Kritikos, I A Mouzas, E A Kouroumalis, O N Manousos (1998) <i>Dig Dis Sci</i> <i></i> <i></i> 43: 11 2507-2512<br/>

http://publicationslist.org/ikoutroub/refid58 2007-09-22T16:34:37Z

OBJECTIVE: To investigate a polymorphism within intron 2 of the interleukin-1 receptor antagonist (IL-1ra) gene in a Dutch white population of patients with ulcerative colitis and Crohn's disease. DESIGN: Genotype and allele frequencies of the polymorphic region in the IL-1ra gene were determined in 111 unrelated patients with ulcerative colitis, 92 patients with Crohn's disease, and 86 healthy co...<br/><br/>G Bioque, G Bouma, J B Crusius, I Koutroubakis, P J Kostense, S G Meuwissen, A S Peña (1996) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 8: 2 105-110<br/>

http://publicationslist.org/ikoutroub/refid57 2007-09-22T16:34:37Z

In 153 patients with IBD, 64 with Crohn's disease (CD), and 89 with ulcerative colitis (UC), as well as in 54 healthy controls (HC), the frequencies of four known di-allelic polymorphisms in the genes for TNF-alpha and lymphotoxin alpha (LTalpha) were investigated. In the Dutch population, the alleles of these four polymorphisms are present in only five combinations, called TNF haplotypes: TNF-C, ...<br/><br/>G Bouma, B Xia, J B Crusius, G Bioque, I Koutroubakis, B M Von Blomberg, S G Meuwissen, A S Peña (1996) <i>Clin Exp Immunol</i> <i></i> <i></i> 103: 3 391-396<br/>

http://publicationslist.org/ikoutroub/refid55 2007-09-22T16:34:37Z

BACKGROUND: There has been an impression from published work that Crohn's disease is less common in southern than in northern Europe. A low incidence of Crohn's disease has been observed in Greece, but conclusive data are still lacking. METHOD: A 5-year prospective and population-based epidemiologic study of Crohn's disease was carried out in a well-defined area of Crete. RESULTS: The mean annual ...<br/><br/>O N Manousos, I Koutroubakis, S Potamianos, M Roussomoustakaki, N Gourtsoyiannis, I G Vlachonikolis (1996) <i>Scand J Gastroenterol</i> <i></i> <i></i> 31: 6 599-603<br/>

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Besides a genetic predisposition, a causal role of various environmental factors have been taken into consideration in the etiology of inflammatory bowel disease (IBD). The most consistent association of environmental factors so far identified is the association between non smoking and ulcerative colitis (UC) as well a between smoking and Crohn's disease (CD). Other factors such as oral contracept...<br/><br/>I Koutroubakis, O N Manousos, S G Meuwissen, A S Pena (1996) <i>Hepatogastroenterology</i> <i></i> <i></i> 43: 8 381-393<br/>

http://publicationslist.org/ikoutroub/refid54 2007-09-22T16:34:37Z

OBJECTIVE: To study the incidence of ulcerative colitis and to analyse the pattern of the disease in the prefecture of Heraklion, Crete. PARTICIPANTS: The population at risk comprised 263,670 inhabitants in the prefecture of Heraklion (2641 km2). The two regional hospitals, five health centres, 109 private family doctors and 145 specialists participated in the study. METHODS: A prospective and pop...<br/><br/>O N Manousos, E Giannadaki, I A Mouzas, M Tzardi, I Koutroubakis, P Skordilis, S Vassilakis, E Kouroumalis, I G Vlachonikolis (1996) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 8: 9 893-898<br/>

http://publicationslist.org/ikoutroub/refid60 2007-09-22T16:34:37Z

Recent reports have shown that allele 2 of the IL-1 receptor antagonist (IL-1Ra) gene is over-represented in ulcerative colitis (UC). Healthy individuals carrying allele 2 of this gene have increased production of IL-1Ra protein. Since the final outcome of the biological effects of IL-1 beta may depend on the relative proportion of these two cytokines, we have studied if a TaqI polymorphism in the...<br/><br/>G Bioque, J B Crusius, I Koutroubakis, G Bouma, P J Kostense, S G Meuwissen, A S Peña (1995) <i>Clin Exp Immunol</i> <i></i> <i></i> 102: 2 379-383<br/>

http://publicationslist.org/ikoutroub/refid59 2007-09-22T16:34:37Z

I Koutroubakis, J B Crusius, A S Peña (1995) <i>Scand J Gastroenterol</i> <i></i> <i></i> 30: 12 1139-1146<br/>