istvan mucsi's Publications List

Sleep disorders and quality of life in renal transplant recipients.

2009-04-01T16:37:14Z

Kidney transplantation provides the best outcome for patients with end-stage renal failure both in terms of morbidity and mortality and health-related quality of life (QoL). Health-related QoL has become recognized as an important outcome measure in patients with different chronic medical conditions, including chronic kidney disease (CKD). There are several factors in kidney-transplanted patients ...

Molnar, Novak, Mucsi (2009) Int Urol Nephrol :

Sociodemographic factors and patient perceptions are associated with attitudes to kidney transplantation among haemodialysis patients.

2009-04-01T16:37:14Z

BACKGROUND: Treatment decisions made by patients with chronic kidney disease are crucial in the renal transplantation process. These decisions are influenced, amongst other factors, by attitudes towards different treatment options, which are modulated by knowledge and perceptions about the disease and its treatment and many other subjective factors. Here we study the attitude of dialysis patients ...

Eszter Panna Vamos, Gabor Csepanyi, Monika Zambo, Miklos Zsolt Molnar, Janos Rethelyi, Agnes Kovacs, Adrienn Marton, Zsofia Nemeth, Marta Novak, Istvan Mucsi (2009) Nephrol Dial Transplant 24: 2 653-660

Transforming growth factor- -induced alpha-smooth muscle cell actin expression in renal proximal tubular cells is regulated by p38 mitogen-activated protein kinase, extracellular signal-regulated protein kinase1,2 and the Smad signalling during epithelial myofibroblast transdifferentiation.

2008-01-27T17:35:36Z

BACKGROUND: Transforming growth factor-beta (TGFbeta)-induced epithelial-myofibroblast transdifferentiation is a central mechanism contributing to the pathogenesis of progressive tubulo-interstitial fibrosis. We wanted to dissect the role of extracellular signal-regulated protein kinase (ERK1,2), p38 mitogen-activated protein kinase (p38 MAPK) and the receptor-regulated Smad proteins in the regula...

Sebe, Leivonen, Fintha, Masszi, Rosivall, Kähäri, Mucsi (2008) Nephrol Dial Transplant :

Rac, PAK and p38 regulate cell contact-dependent nuclear translocation of myocardin-related transcription factor.

2009-04-01T16:37:14Z

We investigated the mechanism whereby cell contact injury stimulates the alpha-smooth muscle actin (SMA) promoter, a key process for epithelial-mesenchymal transition (EMT) during organ fibrosis. Contact disruption by low-Ca(2+) medium (LCM) activated Rac, PAK and p38 MAPK, and triggered the nuclear accumulation of myocardin-related transcription factor (MRTF), an inducer of the SMA promoter. Domi...

Attila Sebe, András Masszi, Matthew Zulys, Tony Yeung, Pam Speight, Ori D Rotstein, Hiroyasu Nakano, István Mucsi, Katalin Szászi, András Kapus (2008) FEBS Lett 582: 2 291-298

Increased renal renin content in mice lacking the Na+/H+ exchanger NHE2.

2009-04-01T16:37:14Z

Macula densa (MD) cells express the Na(+)/H(+) exchanger (NHE) isoform NHE2 at the apical membrane, which may play an important role in tubular salt sensing through the regulation of cell volume and intracellular pH. These studies aimed to determine whether NHE2 participates in the MD control of renin synthesis. Renal renin content and activity and elements of the MD signaling pathway were analyze...

Fiona Hanner, Régine Chambrey, Soline Bourgeois, Elliott Meer, István Mucsi, László Rosivall, Gary E Shull, John N Lorenz, Dominique Eladari, János Peti-Peterdi (2008) Am J Physiol Renal Physiol 294: 4 F937-F944

Prevalence of diabetes in a large, nationally representative population sample in Hungary.

2009-04-01T16:37:14Z

We examined the prevalence of diabetes in a large, Hungarian, nationally representative adult population sample. The overall prevalence of diabetes was 6.2% (95% CI: 5.7-6.6). Increasing age and body mass index (BMI), male gender, physical inactivity, lower self-reported financial status, hypertension and non-smoking were independently associated with diabetes.

Eszter P Vamos, Maria S Kopp, Andras Keszei, Marta Novak, Istvan Mucsi (2008) Diabetes Res Clin Pract 81: 3 e5-e8

Cardiovascular disease and health-care utilization in snorers: a population survey.

2009-04-01T16:37:14Z

STUDY OBJECTIVES: We assessed the prevalence of self-reported snoring in the Hungarian population and established whether different types of snoring are associated with cardiovascular disorders and increased health-care utilization. DESIGN: Cross-sectional study. Door-to-door survey. SETTING: Nationally representative population in Hungary. PARTICIPANTS: Interviews were carried out in the homes of...

Andrea Dunai, Andras P Keszei, Maria S Kopp, Colin M Shapiro, Istvan Mucsi, Marta Novak (2008) Sleep 31: 3 411-416

The role of family physicians in the recognition and screening of obstructive sleep apnea

2009-04-01T16:37:14Z

Obstructive sleep apnea is the most frequent sleep disorder. The prevalence of sleep apnea in the general population is 2-4% and the main characteristic of the disease is the intermittent cessation or substantial reduction of airflow during sleep, caused by complete, or near complete upper airway obstruction. Decreased airflow is followed by oxygen desaturation and intermittent arousals. The clini...

Péter Torzsa, Márta Novák, István Mucsi, Agnes Adám, László Kalabay (2008) Orv Hetil 149: 48 2283-2290

Co-morbidity and quality of life in chronic kidney disease patients.

2009-04-01T16:37:14Z

Chronic kidney disease (CKD) is frequently associated with other chronic medical conditions. Adjusting for potential confounding factors that are associated with the outcome of interest is important both in clinical research and in everyday clinical practice. Comorbidity is such an important co-variable that it is reported to predict different outcomes in patients with ESRD. Health related quality...

Istvan Mucsi, Agnes Zsofia Kovacs, Miklos Zsolt Molnar, Marta Novak (2008) J Nephrol 21 Suppl 13: S84-S91

Anemia is associated with mortality in kidney-transplanted patients--a prospective cohort study.

2008-01-27T17:35:36Z

Although anemia is a known risk factor of mortality in several patient populations, no prospective study to date has demonstrated association between anemia and mortality in kidney-transplanted patients. In our prospective cohort study (TransQol-HU Study), we tested the hypothesis that anemia is associated with mortality and graft failure (return to dialysis) in transplanted patients. Data from 93...

M Z Molnar, M Czira, C Ambrus, L Szeifert, A Szentkiralyi, G Beko, L Rosivall, A Remport, M Novak, I Mucsi (2007) Am J Transplant 7: 4 818-824

Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway.

2008-01-27T17:35:36Z

Epithelial-mesenchymal-myofibroblast transition (EMT), a key feature in organ fibrosis, is regulated by the state of intercellular contacts. Our recent studies have shown that an initial injury of cell-cell junctions is a prerequisite for transforming growth factor-beta1 (TGF-beta1)-induced transdifferentiation of kidney tubular cells into alpha-smooth muscle actin (SMA)-expressing myofibroblasts....

Lingzhi Fan, Attila Sebe, Zalán Péterfi, András Masszi, Ana C P Thirone, Ori D Rotstein, Hiroyasu Nakano, Christopher A McCulloch, Katalin Szászi, István Mucsi, András Kapus (2007) Mol Biol Cell 18: 3 1083-1097

Epithelial-mesenchymal transition in renal tubular cells in the pathogenesis of progressive tubulo-interstitial fibrosis.

2008-01-27T17:35:36Z

Epithelial-mesenchymal transition (EMT) plays an important role in embryogenesis and organ formation. Over the last 10-15 years it has been established that EMT is a significant mechanism of tumor progression and metastasis formation and also of progressive tissue fibrosis in the kidney, liver and lung. EMT seen in these diverse physiological and pathophysiological contexts shares a number of stag...

I Mucsi, L Rosivall (2007) Acta Physiol Hung 94: 1-2 117-131

Angiotensin II activates plasminogen activator inhibitor-I promoter in renal tubular epithelial cells via the AT1 receptor.

2008-01-27T17:35:36Z

BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) regulates normal extracellular matrix (ECM) metabolism and it is a key regulator of the fibrotic process. Both angiotensin II (Ang II) and angiotensin IV (Ang IV) have been reported to stimulate PAI-1 expression. It is not known how PAI-1 expression is regulated by the renin-angiotensin system (RAS) in renal tubular cells. METHODS: To dissect s...

A Fintha, A Sebe, A Masszi, T Terebessy, T Huszár, L Rosivall, I Mucsi (2007) Acta Physiol Hung 94: 1-2 19-30

Restless legs syndrome and mortality in kidney transplant recipients.

2008-01-27T17:35:36Z

BACKGROUND: Previous studies showed an association between the presence of restless legs syndrome (RLS) and mortality in patients on dialysis therapy. An association between RLS and cardiovascular risk also was reported in the general population. However, no prospective study to date assessed the association between the presence of RLS and mortality in kidney transplant recipients. In a prospectiv...

Miklos Zsolt Molnar, Andras Szentkiralyi, Anett Lindner, Maria Eszter Czira, Lilla Szeifert, Agnes Zsofia Kovacs, Katalin Fornadi, Andras Szabo, Laszlo Rosivall, Istvan Mucsi, Marta Novak (2007) Am J Kidney Dis 50: 5 813-820

High prevalence of patients with a high risk for obstructive sleep apnoea syndrome after kidney transplantation--association with declining renal function.

2008-01-27T17:35:36Z

BACKGROUND: Obstructive sleep apnoea syndrome (OSAS) is much more prevalent in patients on dialysis than in the general population. Our aim was to assess for the first time the prevalence of patients with a high risk for OSAS and its clinical correlates in a large sample of kidney transplanted patients. We also wanted to compare the prevalence of the disorder between waitlisted dialysis patients (...

Miklos Zsolt Molnar, Andras Szentkiralyi, Anett Lindner, Maria Eszter Czira, Andras Szabo, Istvan Mucsi, Marta Novak (2007) Nephrol Dial Transplant 22: 9 2686-2692

Confirming high prevalence of patients with a high risk for obstructive sleep apnoea syndrome (OSAS) after kidney transplantation reply.

2008-01-27T17:35:36Z

Molnar, Mucsi, Novak (2007) Nephrol Dial Transplant :

Restless legs syndrome, insomnia, and quality of life after renal transplantation.

2008-01-27T17:35:36Z

OBJECTIVE: Restless legs syndrome (RLS) is associated with insomnia and impaired quality of life (QoL) in patients on maintenance dialysis; however, no information has been published on the association of RLS and QoL in kidney-transplanted patients. In a cross-sectional study, we analyzed the complex relationship between RLS, insomnia, and health-related QoL in kidney-transplanted patients. METHOD...

Miklos Zsolt Molnar, Marta Novak, Lilla Szeifert, Csaba Ambrus, Andras Keszei, Agnes Koczy, Anett Lindner, Szabolcs Barotfi, Andras Szentkiralyi, Adam Remport, Istvan Mucsi (2007) J Psychosom Res 63: 6 591-597

Management of restless legs syndrome in patients on dialysis.

2008-01-27T17:35:36Z

Restless legs syndrome (RLS) is characterised by an urge to move the legs, uncomfortable sensations in the legs and worsening of these symptoms during rest with at least temporary relief brought on by activity. RLS occurs in 3-15% of the general population and in 10-30% of patients on maintenance dialysis. RLS may lead to severe sleep onset or maintenance insomnia, and greatly impaired quality of ...

Miklos Z Molnar, Marta Novak, Istvan Mucsi (2006) Drugs 66: 5 607-624

Diagnosis and management of insomnia in dialysis patients.

2008-01-27T17:35:36Z

Sleep-related complaints affect 50-80% of patients on dialysis. Sleep disorders impair quality of life significantly. Increasing evidence suggests that sleep disruption has a profound impact both on an individual and on a societal level. The etiology of sleep disorders is often multifactorial: biologic, social, and psychological factors play a role. This is especially true for insomnia, which is t...

Marta Novak, Colin M Shapiro, David Mendelssohn, Istvan Mucsi (2006) Semin Dial 19: 1 25-31

Chronic insomnia in kidney transplant recipients.

2008-01-27T17:35:36Z

BACKGROUND: Recent studies confirmed that sleep disorders have a significant impact on various aspects of health in patients at different stages of chronic kidney disease. At the same time, there is an almost complete lack of information on the prevalence and correlates of insomnia in kidney transplant recipients. METHODS: In a cross-sectional study, the Athens Insomnia Scale was used to assess th...

Marta Novak, Miklos Zs Molnar, Csaba Ambrus, Agnes Zs Kovacs, Agnes Koczy, Adam Remport, Lilla Szeifert, Andras Szentkiralyi, Colin M Shapiro, Maria S Kopp, Istvan Mucsi (2006) Am J Kidney Dis 47: 4 655-665

Validation of the Kidney Disease Quality of Life-Short Form questionnaire in kidney transplant patients.

2008-01-27T17:35:36Z

OBJECTIVE: The aim of this study was to determine the basic psychometric properties, reliability, and validity of the Kidney Disease Quality of Life-Short Form (KDQOL-SF) questionnaire in kidney transplant patients. METHODS: The reliability and validity of the instrument were determined in 418 kidney transplant patients followed in a single outpatient transplant centre. RESULTS: Internal consisten...

Szabolcs Barotfi, Miklos Zs Molnar, Csilla Almasi, Agnes Zs Kovacs, Adam Remport, Lilla Szeifert, Andras Szentkiralyi, Eszter Vamos, Rezso Zoller, Sonya Eremenco, Marta Novak, Istvan Mucsi (2006) J Psychosom Res 60: 5 495-504

Diagnosis and management of sleep apnea syndrome and restless legs syndrome in dialysis patients.

2008-01-27T17:35:36Z

Sleep complaints are very common in patients with end-stage renal disease (ESRD) and contribute to their impaired quality of life. Both obstructive and central sleep apnea syndromes are reported more often in patients on dialysis than in the general population. Impaired daytime functioning, sleepiness, and fatigue, as well as cognitive problems, are well known in patients with sleep apnea. Increas...

Marta Novak, David Mendelssohn, Colin M Shapiro, Istvan Mucsi (2006) Semin Dial 19: 3 210-216

Obstructive sleep apnea and cardiovascular disease

2008-01-27T17:35:36Z

Obstructive sleep apnea is an increasingly common disorder and it is a novel cardiovascular disease risk factor. Repetitive apneas and hypopneas during sleep are accompanied by hypoxia, increased sympathetic activity and frequent arousals. Sleep apnea has clearly been demonstrated to be an independent risk factor for development of hypertension and it has also been implicated in the pathogenesis o...

Andrea Dunai, István Mucsi, János Juhász, Márta Novák (2006) Orv Hetil 147: 48 2303-2311

Obstructive sleep apnea and cardiovascular disease

2008-01-27T17:35:36Z

Sleep-related breathing disorders are prevalent in the general population and are associated with a wide range of cardiovascular diseases. Obstructive sleep apnea is the most common form of sleep-related breathing disorders and is characterized by repetitive episodes of partial or complete upper airway obstruction, followed by oxygen-desaturation and arousals. These apneic events disrupt normal sl...

Andrea Dunai, István Mucsi, János Juhász, Márta Novák (2006) Orv Hetil 147: 33 1559-1564

Restless legs syndrome, insomnia and quality of life in patients on maintenance dialysis.

2008-01-27T17:35:36Z

BACKGROUND: In a cross-sectional study, we analysed the complex relationship between restless legs syndrome (RLS), insomnia and specific insomnia symptoms and health-related quality of life (QoL) in patients on maintenance dialysis. METHODS: Data were obtained from 333 patients on chronic maintenance dialysis. To assess the prevalence of RLS, we used the RLS Questionnaire (RLSQ). The Athens Insomn...

Istvan Mucsi, Miklos Zsolt Molnar, Csaba Ambrus, Lilla Szeifert, Agnes Zsofia Kovacs, Rezso Zoller, Szabolcs Barótfi, Adam Remport, Marta Novak (2005) Nephrol Dial Transplant 20: 3 571-577

Factor structure and reliability of the Hungarian version of the Illness Intrusiveness Scale: invariance across North American and Hungarian dialysis patients.

2008-01-27T17:35:36Z

OBJECTIVES: The objectives of this study were to compare the factor structure and to assess the reliability of the Hungarian version of the Illness Intrusiveness Rating Scale (IIRS), testing internal validity and employing simultaneous confirmatory factor analysis (SCFA) in two large samples of North American versus Hungarian patients with end-stage renal disease (ESRD). METHODS: Translation was c...

Marta Novak, Kenneth Mah, Miklos Zs Molnar, Csaba Ambrus, Gabor Csepanyi, Agnes Kovacs, Eszter Vamos, Monika Zambo, Rezso Zoller, Istvan Mucsi, Gerald M Devins (2005) J Psychosom Res 58: 1 103-110

Restless Legs Syndrome in patients after renal transplantation.

2008-01-27T17:35:36Z

BACKGROUND: There is an almost complete lack of information on the epidemiology of sleep disorders in kidney-transplanted patients. In this report the authors assess the prevalence and clinical correlates of restless legs syndrome (RLS) in kidney-transplanted (Tx) patients. They also analyze the impact of declining renal function on this condition in the Tx population. Finally, the prevalence of R...

Miklos Zsolt Molnar, Marta Novak, Csaba Ambrus, Lilla Szeifert, Agnes Kovacs, Judit Pap, Adam Remport, Istvan Mucsi (2005) Am J Kidney Dis 45: 2 388-396

Anemia in kidney transplanted patients.

2008-01-27T17:35:36Z

BACKGROUND: Although a known cardiovascular risk factor, anemia in the renal transplant recipients has only recently been receiving an increasing attention. METHODS: In a cross-sectional study, data was obtained from 959 patients followed at a single outpatient transplant clinic. Based on the guideline of the American Society of Transplantation, anemia was defined as hemoglobin (Hb) < or =130 g/L ...

Miklos Zs Molnar, Marta Novak, Csaba Ambrus, Agnes Kovacs, Judit Pap, Adam Remport, Lilla Szeifert, Istvan Mucsi (2005) Clin Transplant 19: 6 825-833

Serum 25(OH)-vitamin D levels and bone metabolism in patients on maintenance hemodialysis.

2008-01-27T17:35:36Z

AIMS: An increasing amount of evidence suggests that 25-hydroxy vitamin D3 (25(OH)D3) may contribute to the bone health of patients with chronic kidney disease (CKD). The underlying vitamin D status of these patients, however, has often been neglected. In a cross-sectional study we assessed the association between vitamin D status and parathyroid function, bone turnover, bone mass and structure in...

I Mucsi, C Almási, G Deák, A Marton, C Ambrus, K Berta, P Lakatos, A Szabó, C Horváth (2005) Clin Nephrol 64: 4 288-294

Sleep disorders and illness intrusiveness in patients on chronic dialysis.

2008-01-27T17:35:36Z

BACKGROUND: The prevalence of sleep problems (insomnia, restless legs syndrome, periodic limb movements in sleep and sleep apnoea) has been shown to be high in patients with end-stage renal disease (ESRD) and might contribute to impaired quality of life in this population. METHODS: In a cross-sectional study using self-administered questionnaires, we examined the prevalence of sleep disorders and ...

Istvan Mucsi, Miklos Zs Molnar, Janos Rethelyi, Eszter Vamos, Gabor Csepanyi, Gyorgyi Tompa, Szabolcs Barotfi, Adrienn Marton, Marta Novak (2004) Nephrol Dial Transplant 19: 7 1815-1822

Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin.

2008-01-27T17:35:36Z

Injury of the tubular epithelium and TGF-beta1-induced conversion of epithelial cells to alpha-smooth muscle actin (SMA)-expressing myofibroblasts are key features of kidney fibrosis. Since injury damages intercellular junctions and promotes fibrosis, we hypothesized that cell contacts are critical regulators of TGF-beta 1-triggered epithelial-to-mesenchymal transition (EMT). Here we show that TGF...

András Masszi, Lingzhi Fan, László Rosivall, Christopher A McCulloch, Ori D Rotstein, István Mucsi, András Kapus (2004) Am J Pathol 165: 6 1955-1967

Increased utilization of health services by insomniacs--an epidemiological perspective.

2008-01-27T17:35:36Z

OBJECTIVES: Epidemiological data describing the prevalence of sleep complaints in Hungary and its region are lacking; furthermore, limited information is available on health care use by individuals with sleep complaints. We assessed the prevalence of sleep complaints, insomnia in particular, in a nationally representative sample of the Hungarian population and assessed health care utilization by i...

Marta Novak, Istvan Mucsi, Colin M Shapiro, Janos Rethelyi, Maria S Kopp (2004) J Psychosom Res 56: 5 527-536

Angiotensin II activates the human renin promoter in an in vitro model: the role of c-Jun-N-terminal kinase.

2008-01-27T17:35:36Z

BACKGROUND: Angiotensin II (Ang II) down-regulates renin expression in juxtaglomerular cells, however, recent experimental evidence obtained in transgenic mice suggested that Ang II may "paradoxically" increase transcriptional activity of the proximal renin promoter. METHODS: To dissect signalling mechanisms contributing to the up-regulation of the proximal renin promoter by Ang II, porcine proxim...

Tamás Terebessy, András Masszi, Attila Fintha, Attila Sebe, Tamás Huszár, László Rosivall, István Mucsi (2004) Nephrol Dial Transplant 19: 9 2184-2191

Estradiol is nephroprotective in the rat remnant kidney.

2008-01-27T17:35:36Z

BACKGROUND: Female sex hormones may influence the progression of renal diseases. We therefore evaluated the effects of estradiol on the development of glomerulosclerosis in a remnant kidney model. METHODS: Ovariectomized or intact female Wistar rats underwent 5/6 nephrectomy. Ovariectomized animals were treated with vehicle, 17beta-estradiol alone or in combination with progesterone, intact rats r...

Balazs Antus, Peter Hamar, Gabor Kokeny, Zoltan Szollosi, Istvan Mucsi, Zoltan Nemes, Laszlo Rosivall (2003) Nephrol Dial Transplant 18: 1 54-61

Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition.

2008-01-27T17:35:36Z

New research suggests that, during tubulointerstitial fibrosis, alpha-smooth muscle actin (SMA)-expressing mesenchymal cells might derive from the tubular epithelium via epithelial-mesenchymal transition (EMT). Although transforming growth factor-beta(1) (TGF-beta(1)) plays a key role in EMT, the underlying cellular mechanisms are not well understood. Here we characterized TGF-beta(1)-induced EMT ...

Andras Masszi, Caterina Di Ciano, Gábor Sirokmány, William T Arthur, Ori D Rotstein, Jiaxu Wang, Christopher A G McCulloch, László Rosivall, István Mucsi, András Kapus (2003) Am J Physiol Renal Physiol 284: 5 F911-F924

Significance and practical aspects of quality-of-life research

2008-01-27T17:35:36Z

Over the past ten-fifteen years there has been a continuous increase in the interest in quality of life research. There is a huge increase in the number of clinical trials applying quality of life as an outcome measure and also in the number of studies where assessment of quality of life is the main focus of the research. During the last decades the resources of health care has increasingly been d...

Márta Novák, Adrienne Stauder, István Mucsi (2003) Orv Hetil 144: 21 1031-1038

Role of mitogen-activated protein kinase cascade in the intracellular signaling of angiotensin II

2008-01-27T17:35:36Z

It has been recently recognized that angiotensin II (Ang II), in addition to its role in the regulation of the salt-fluid homeostasis is also a growth factor and contributes to the regulation of cellular hypertrophy or proliferation and extracellular matrix (ECM) formation. This article gives an overview on the role of mitogen activated protein kinase (MAPK) cascades in transducing the growth fact...

Tamás Huszár, András Masszi, István Mucsi, László Rosivall (2003) Orv Hetil 144: 31 1537-1543

Renal replacement therapy in Hungary: the decade of transition.

2008-01-27T17:35:36Z

Zsolt Mogyorosy, Istvan Mucsi, Laszlo Rosivall (2003) Nephrol Dial Transplant 18: 6 1066-1071

Overexpression of the type II transforming growth factor-beta receptor inhibits fibroblasts proliferation and activates extracellular signal regulated kinase and c-Jun N-terminal kinase.

2008-01-27T17:35:36Z

Transforming growth factor-beta (TGF-beta) is a bimodal regulator of cellular growth. The cellular effects of TGF-beta depend on the intensity of signals emanating from TGF-beta receptors. Low levels of receptor activity are sufficient to stimulate cell proliferation, while higher degrees of receptor activation are associated with growth inhibition. To study the mechanisms of these effects, a tetr...

Howard J Goldberg, Tamás Huszár, Miklós M Mózes, László Rosivall, István Mucsi (2002) Cell Biol Int 26: 2 165-174

Extracellular signal-regulated kinase and the small GTP-binding protein p21Rac1 are involved in the regulation of gene transcription by angiotensin II.

2008-01-27T17:35:36Z

To study the role of extracellular-signal-regulated kinase (ERK) cascade and the small GTP-ase proteins in the activation of the c-fos promoter by angiotensin II (AII), transient transfection experiments were performed in CHO cells stably expressing the rat AT(1A) receptor. In this system AII activated ERK in 1 min and also increased the transcriptional activity of the c-fos promoter-luciferase re...

T Huszár, I Mucsi, B Antus, T Terebessy, C Jeney, A Masszi, L Hunyady, B Mihalik, H J Goldberg, T J Thekkumkara, L Rosivall (2001) Exp Nephrol 9: 2 142-149

The use of a second reporter plasmid as an internal standard to normalize luciferase activity in transient transfection experiments may lead to a systematic error.

2008-01-27T17:35:36Z

beta-galactosidase reporter plasmids containing different viral or minimal promoters are commonly used to correct variable transfection efficiencies in transient transfection experiments. The transcriptional activity of these promoters is thought to be stable under most circumstances. To determine if expression of beta-galactosidase from the commonly used beta-galactosidase plasmids remains stable...

T Huszár, I Mucsi, T Terebessy, A Masszi, S Adamkó, C Jeney, L Rosivall (2001) J Biotechnol 88: 3 251-258

Apoptosis induction and inhibition of cellular proliferation by angiotensin II: possible implication and perspectives.

2008-01-27T17:35:36Z

The renin-angiotensin system plays a pivotal role in the regulation of fluid, electrolyte metabolism and blood pressure. Molecular cloning and pharmacological studies have defined two major classes of Angiotensin II (Ang II) receptors, designated AT1 and AT2. Recently, it has been well recognized that Ang II, beside its classical physiological actions, is a profibrogenic peptide and displays chara...

B Antus, I Mucsi, L Rosivall (2000) Acta Physiol Hung 87: 1 5-24

Postmenopausal hormone replacement improves proteinuria and impaired creatinine clearance in type 2 diabetes mellitus and hypertension.

2008-01-27T17:35:36Z

OBJECTIVE: To determine whether hormone replacement therapy can reverse established renal microvascular damage in type 2 diabetes and hypertension. DESIGN: Prospective, single centre clinical trial. SETTING: Outpatient clinics. PARTICIPANTS: Sixteen diabetic and hypertensive postmenopausal women (age 47-57 years) METHODS: Administration of a cyclic combination of oestradiol and norgestrel orally f...

B Szekacs, Z Vajo, S Varbiro, R Kakucs, L Vaslaki, N Acs, I Mucsi, E A Brinton (2000) BJOG 107: 8 1017-1021

Relative hypoparathyroidism and adynamic bone disease.

2008-01-27T17:35:36Z

Renal bone disease results in significant morbidity in patients with end-stage renal failure. Renal osteodystrophy is a mixture of different conditions with different pathogenetic factors involved. Most recently a new form of renal bone disease, adynamic bone disease, has emerged as the most frequent finding on bone biopsy of patients on dialysis therapy. The etiology of this new entity is not ful...

I Mucsi, G Hercz (1999) Am J Med Sci 317: 6 405-409

Control of serum phosphate without any phosphate binders in patients treated with nocturnal hemodialysis.

2008-01-27T17:35:36Z

We compared the efficacy and the long-term effects of nocturnal hemodialysis (NHD) versus conventional hemodialysis (CHD) in controlling serum phosphate levels in patients with end-stage renal disease (ESRD). Patients underwent thrice weekly CHD and were subsequently switched to NHD six nights weekly. In the "acute" study serum and dialysate phosphate were measured during and after dialysis, and t...

I Mucsi, G Hercz, R Uldall, M Ouwendyk, R Francoeur, A Pierratos (1998) Kidney Int 53: 5 1399-1404

Control of serum phosphate in patients with renal failure--new approaches.

2008-01-27T17:35:36Z

I Mucsi, G Hercz (1998) Nephrol Dial Transplant 13: 10 2457-2460

Dominant-negative SMAD-3 interferes with transcriptional activation by multiple agonists.

2008-01-27T17:35:36Z

Smad proteins have recently been identified as mediators of transcriptional activation by members of the transforming growth factor-beta superfamily. To determine if Smads might also be involved in inducing gene transcription in response to other agonists, expression vectors for dominant-negative Smad proteins were constructed. These plasmids were transiently cotransfected with luciferase reporter...

I Mucsi, H J Goldberg (1997) Biochem Biophys Res Commun 232: 2 517-521

Adynamic bone disease: pathogenesis, diagnosis and clinical relevance.

2008-01-27T17:35:36Z

In the past several years significant attention has been directed to the study of adynamic bone disease in uremic patients. Several reports have provided additional information about the prevalence of adynamic bone disease in different countries. It has now become clear that the pathogenesis of adynamic bone disease cannot be ascribed to one single aetiological factor, but rather to a host of comp...

I Mucsi, G Hercz (1997) Curr Opin Nephrol Hypertens 6: 4 356-361

Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression.

2008-01-27T17:35:36Z

The kinases and regulatory proteins that convey signals initiated by transforming growth factor-beta (TGF-beta) to the nucleus are poorly characterized. To study the role of the extracellular signal-regulated kinase (ERK) pathway in this process, we transiently transfected NIH 3T3 fibroblasts with TGF-beta-responsive luciferase reporter genes and expression vectors designed to interrupt this kinas...

I Mucsi, K L Skorecki, H J Goldberg (1996) J Biol Chem 271: 28 16567-16572

The role of guanyl nucleotide binding proteins in the formation of inositol phosphates in adrenal glomerulosa cells.

2008-01-27T17:35:36Z

A non-hydrolysable GTP analogue enhanced the formation of [3H]inositol polyphosphates in permeabilized adrenal glomerulosa cells. Pertussis toxin, which ADP-ribosylated Ni, failed to influence angiotensin-induced formation of 3H-labelled inositol phosphates and the incorporation of [32F]phosphate into phosphatidylinositol and phosphatidic acid. These results show that Ni is present and a G-protein...

P Enyedi, I Mucsi, L Hunyady, K J Catt, A Spät (1986) Biochem Biophys Res Commun 140: 3 941-947