http://publicationslist.org/data/j.vuyk/atom.xml Jaap Vuykhttp://publicationslist.org/j.vuyk$basepathfavicon.icoRecent additions to Jaap Vuyk's PublicationsList.org pagehttp://publicationslist.org/publications.png2011-04-21T12:19:11Z http://publicationslist.org/j.vuyk/refid1 2011-04-21T12:17:24Z

The time-course of the neuromuscular blocking effect of rocuronium depends on circulatory mixing and the rate of distribution into the interstitial space. In order to quantitatively evaluate these processes, a physiologically meaningful model of distribution kinetics based on circulatory transport and interstitial diffusion, was fitted to rocuronium disposition data in 10 patients using a populati...<br/><br/>Michael Weiss, Marije Reekers, Jaap Vuyk, Fred Boer (2011) <i>J Pharmacokinet Pharmacodyn</i> <i></i> <i></i> 38: 2 165-178<br/>

http://publicationslist.org/j.vuyk/refid4 2011-04-21T12:17:24Z

Indocyanine green plasma disappearance rate (ICG-PDR) is used to evaluate hepatic function. Although hepatic failure is generally said to occur with an ICG-PDR <18%/min, ICG disappearance rate is poorly defined in the healthy population, and a clear cutoff value of ICG-PDR that discriminates between normal hepatic function and hepatic failure has not yet been described. We therefore defined the IC...<br/><br/>Marije Reekers, Mischa J G Simon, Fred Boer, René A G Mooren, Jack W van Kleef, Albert Dahan, Jaap Vuyk (2010) <i>Anesth Analg</i> <i></i> <i></i> 110: 2 466-472<br/>

http://publicationslist.org/j.vuyk/refid3 2011-04-21T12:17:24Z

Sporadic pheochromocytomas are detected by clinical signs and symptoms, whereas pheochromocytomas in patients with a known hereditary predisposition for these tumors are detected by repetitive screening for catecholamine excess.<br/><br/>N van Duinen, D Steenvoorden, B A Bonsing, J Vuyk, A H J T Vriends, J C Jansen, J A Romijn, E P M Corssmit (2010) <i>Eur J Endocrinol</i> <i></i> <i></i> 163: 1 121-127<br/>

http://publicationslist.org/j.vuyk/refid2 2011-04-21T12:17:24Z

Midazolam, at sedative levels, increases blood propofol concentrations by 25%. We evaluated the reverse interaction and determined the influence of propofol on the pharmacokinetics of midazolam.<br/><br/>Bart Jan Lichtenbelt, Erik Olofsen, Albert Dahan, Jack W van Kleef, Michel M R F Struys, Jaap Vuyk (2010) <i>Anesth Analg</i> <i></i> <i></i> 110: 6 1597-1606<br/>

http://publicationslist.org/j.vuyk/refid6 2011-04-21T12:17:24Z

The combined administration of anesthetics has been associated with pharmacokinetic interactions that induce concentration changes of up to 30%. Midazolam is often used as a preoperative sedative in advance of a propofol-based anesthetic. In this study, we identified the influence of midazolam on the pharmacokinetics of propofol.<br/><br/>Jaap Vuyk, Bart Jan Lichtenbelt, Erik Olofsen, Jack W van Kleef, Albert Dahan (2009) <i>Anesth Analg</i> <i></i> <i></i> 108: 5 1522-1530<br/>

http://publicationslist.org/j.vuyk/refid5 2011-04-21T12:17:24Z

Noninvasive cardiac output (CO) monitoring is possible by indocyanine green (ICG) dilution measured by pulse dye densitometry (PDD). To validate the precision of this method, we compared hemodynamic variables derived from PDD (DDG-2001, Nihon Kohden, Japan) with those derived from simultaneously taken arterial blood ICG concentrations.<br/><br/>Marije Reekers, Mischa J G Simon, Fred Boer, René A G Mooren, Jack W van Kleef, Albert Dahan, Jaap Vuyk (2009) <i>Anesth Analg</i> <i></i> <i></i> 109: 2 441-446<br/>

http://publicationslist.org/j.vuyk/refid7 2011-04-21T12:17:24Z

Lumbar epidural anaesthesia induces cardiovascular changes and decreases liver blood flow (Qh). We studied the effects of age on haemodynamics, blood volumes and Qh before and after epidural anaesthesia.<br/><br/>Mischa J G Simon, Marije Reekers, Bernadette T Veering, Fred Boer, Anton G L Burm, Jack W van Kleef, Jaap Vuyk (2009) <i>Eur J Anaesthesiol</i> <i></i> <i></i> 26: 2 166-174<br/>

http://publicationslist.org/j.vuyk/refid8 2011-04-21T12:17:24Z

Vuyk, Jaap, Jan Van Den Bos, Kees Terhell, Rene De Bos, Ad Vletter, Pierre Valk, Martie Van Beuzekom, Jack Van Kleef, and Albert Dahan. Acetazolamide improves cerebral oxygenation during exercise at high altitude. High Alt. Med. Biol. 7:290-301, 2006.--Acute mountain sickness is thought to be triggered by cerebral hypoxemia and be prevented by acetazolamide (Actz). The effect of Actz on cerebral o...<br/><br/>Jaap Vuyk, Jan Van Den Bos, Kees Terhell, Rene De Bos, Ad Vletter, Pierre Valk, Martie Van Beuzekom, Jack Van Kleef, Albert Dahan (2006) <i>High Alt Med Biol</i> <i></i> <i></i> 7: 4 290-301<br/>

http://publicationslist.org/j.vuyk/refid15 2011-04-21T12:17:24Z

Jaap Vuyk, Bart Jan Lichtenbelt, Jenny Vieveen, Albert Dahan, Frank H M Engbers, Anton G L Burm (2004) <i>Anesthesiology</i> <i></i> <i></i> 100: 1 179-181<br/>

http://publicationslist.org/j.vuyk/refid14 2011-04-21T12:17:24Z

The influence of alfentanil on the pharmacokinetics of propofol is poorly understood. Therefore, the authors studied the effect of a pseudo-steady state concentration of alfentanil on the pharmacokinetics of propofol.<br/><br/>Martijn J Mertens, Erik Olofsen, Anton G L Burm, James G Bovill, Jaap Vuyk (2004) <i>Anesthesiology</i> <i></i> <i></i> 100: 4 795-805<br/>

http://publicationslist.org/j.vuyk/refid10 2011-04-21T12:17:24Z

Propofol-opioid combinations are widely used in today's anaesthetic practice. Over the past 20-30 years the pharmacology of these agents has been described in increasingly greater detail. Together with novel intravenous administration devices and improved anaesthetic depth monitoring, this has created a basis for the optimisation of the administration of propofol-opioid anaesthesia. This article d...<br/><br/>Bart-Jan Lichtenbelt, Martijn Mertens, Jaap Vuyk (2004) <i>Clin Pharmacokinet</i> <i></i> <i></i> 43: 9 577-593<br/>

http://publicationslist.org/j.vuyk/refid9 2011-04-21T12:17:24Z

Until recently, no measure was available that provided objective and reproducible information on the level of consciousness in patients under general anaesthesia. Several decades of research to find a reliable measure for determining the depth of anaesthesia has now led to the clinical introduction of the bispectral index scale (BIS), a parameter derived from the electroencephalogram. Implementati...<br/><br/>J Vuyk, E J R Egberink, A G L Burm (2004) <i>Ned Tijdschr Geneeskd</i> <i></i> <i></i> 148: 26 1276-1280<br/>

http://publicationslist.org/j.vuyk/refid16 2011-04-21T12:17:24Z

Remifentanil is often combined with propofol for induction and maintenance of total intravenous anesthesia. The authors studied the effect of propofol on remifentanil requirements for suppression of responses to clinically relevant stimuli and evaluated this in relation to previously published data on propofol and alfentanil.<br/><br/>Martijn J Mertens, Erik Olofsen, Frank H M Engbers, Anton G L Burm, James G Bovill, Jaap Vuyk (2003) <i>Anesthesiology</i> <i></i> <i></i> 99: 2 347-359<br/>

http://publicationslist.org/j.vuyk/refid17 2011-04-21T12:17:24Z

An overview is given of the influence of age on the pharmacodynamics of drugs used during general and locoregional anaesthesia. For some groups of agents a distinct separation into age-related changes in the pharmacokinetics and pharmacodynamics is possible, whereas for others the literature indicates only that responses in the elderly are enhanced. I start with an overview of the influence of age...<br/><br/>Jaap Vuyk (2003) <i>Best Pract Res Clin Anaesthesiol</i> <i></i> <i></i> 17: 2 207-218<br/>

http://publicationslist.org/j.vuyk/refid12 2011-04-21T12:17:24Z

Charles Minto, Jaap Vuyk (2003) <i>Adv Exp Med Biol</i> <i></i> <i></i> 523: 35-43<br/>

http://publicationslist.org/j.vuyk/refid11 2011-04-21T12:17:24Z

Jaap Vuyk, Martijn Mertens (2003) <i>Adv Exp Med Biol</i> <i></i> <i></i> 523: 95-104<br/>

http://publicationslist.org/j.vuyk/refid18 2011-04-21T12:17:24Z

Since propofol and remifentanil are frequently combined for monitored anesthesia care, we examined the influence of the separate and combined administration of these agents on cardiorespiratory control and bispectral index in humans.<br/><br/>Diederik J F Nieuwenhuijs, Erik Olofsen, Raymonda R Romberg, Elise Sarton, Denham Ward, Frank Engbers, Jaap Vuyk, Rene Mooren, Luc J Teppema, Albert Dahan (2003) <i>Anesthesiology</i> <i></i> <i></i> 98: 2 312-322<br/>

http://publicationslist.org/j.vuyk/refid13 2011-04-21T12:17:24Z

Marije Reekers, Fred Boer, Jaap Vuyk (2003) <i>Adv Exp Med Biol</i> <i></i> <i></i> 523: 19-26<br/>

http://publicationslist.org/j.vuyk/refid19 2011-04-21T12:17:24Z

The predictive performance of the available pharmacokinetic parameter sets for remifentanil, when used for target-controlled infusion (TCI) during total i.v. anaesthesia, has not been determined in a clinical setting. We studied the predictive performance of five parameter sets of remifentanil when used for TCI of remifentanil during propofol anaesthesia in surgical patients.<br/><br/>M J Mertens, F H M Engbers, A G L Burm, J Vuyk (2003) <i>Br J Anaesth</i> <i></i> <i></i> 90: 2 132-141<br/>

http://publicationslist.org/j.vuyk/refid20 2011-04-21T12:17:24Z

Ventilatory control in humans depends on complex mechanisms which aim to maintain a cellular CO2-, O2- and H(+)-homeostasis under physiological conditions. This regulation is based on chemical control which predominantly acts via peripheral chemoreceptors in the carotid bodies and central chemoreceptors in the ventral medulla of the brainstem on the one hand, and behavioural control on the other, ...<br/><br/>E Sarton, R Romberg, D Nieuwenhuijs, L J Teppema, J Vuyk, S Schraag, A Dahan (2002) <i>Anaesthesist</i> <i></i> <i></i> 51: 4 285-291<br/>

http://publicationslist.org/j.vuyk/refid23 2011-04-21T12:17:24Z

The influence of propofol on the pharmacokinetics of alfentanil is poorly understood. The authors therefore studied the effect of a pseudo-steady state concentration of propofol on the pharmacokinetics of alfentanil.<br/><br/>M J Mertens, J Vuyk, E Olofsen, J G Bovill, A G Burm (2001) <i>Anesthesiology</i> <i></i> <i></i> 94: 6 949-957<br/>

http://publicationslist.org/j.vuyk/refid22 2011-04-21T12:17:24Z

Differences in the pharmacokinetics of propofol between male and female patients during and after continuous infusion have not been described in detail in patients aged 65 yr and older. To increase our insight into the pharmacokinetics of propofol in this patient population and to obtain pharmacokinetic parameters applicable in target controlled infusion (TCI), the pharmacokinetics of propofol dur...<br/><br/>J Vuyk, C J Oostwouder, A A Vletter, A G Burm, J G Bovill (2001) <i>Br J Anaesth</i> <i></i> <i></i> 86: 2 183-188<br/>

http://publicationslist.org/j.vuyk/refid21 2011-04-21T12:17:24Z

This manuscript describes the pharmacokinetic and pharmacodynamic interactions between propofol and the opioids. PHARMACOKINETIC INTERACTIONS: In vitro studies describe the reduced clearance of opioids in the presence of propofol, midazolam and etomidate due to interaction at the cytochrome P450 enzyme system. In vivo, however, pharmacokinetic interaction studies by mixed effects modelling predomi...<br/><br/>J Vuyk (2001) <i>Acta Anaesthesiol Belg</i> <i></i> <i></i> 52: 4 445-451<br/>

http://publicationslist.org/j.vuyk/refid25 2011-04-21T12:17:24Z

Drug delivery by target-controlled infusion (TCI) allows automatic adjustments of the infusion rate of a drug to maintain a desired target concentration. Since drug effect is more closely related to blood concentration than to infusion rate, drug delivery via TCI is capable of creating stable blood concentrations of intravenous anaesthetics and analgesics. In this article the concept and history o...<br/><br/>M C van den Nieuwenhuyzen, F H Engbers, J Vuyk, A G Burm (2000) <i>Clin Pharmacokinet</i> <i></i> <i></i> 38: 2 181-190<br/>

http://publicationslist.org/j.vuyk/refid24 2011-04-21T12:17:24Z

J Vuyk, T Schnider, F Engbers (2000) <i>Anesthesiology</i> <i></i> <i></i> 93: 6 1557-1560<br/>

http://publicationslist.org/j.vuyk/refid26 2011-04-21T12:17:24Z

We have studied the influence of eltanolone on intraoperative alfentanil requirements in 18 female patients undergoing lower abdominal surgery receiving target-controlled infusions of eltanolone and alfentanil. While target concentrations of eltanolone were maintained constant, target concentrations of alfentanil changed in response to the presence or absence of responses. With serum eltanolone co...<br/><br/>M J Mertens, J Vuyk, K Parivar, F H Engbers, A G Burm, J G Bovill (1999) <i>Br J Anaesth</i> <i></i> <i></i> 83: 2 250-252<br/>

http://publicationslist.org/j.vuyk/refid27 2011-04-21T12:17:24Z

Anaesthesia is nowadays seldom accomplished by a single agent because no single agent is able to provide all components of anaesthesia without seriously compromising haemodynamic and/or respiratory function, reducing operating conditions, or postponing postoperative recovery. Because of the small therapeutic window a detailed characterisation of the concentration-effect relationships of anaestheti...<br/><br/>J Vuyk (1999) <i>Minerva Anestesiol</i> <i></i> <i></i> 65: 5 215-218<br/>

http://publicationslist.org/j.vuyk/refid28 2011-04-21T12:17:24Z

The pharmacokinetic and pharmacodynamic interactions between propofol and adjuvant agents have increasingly been recognised as clinically important and the improved knowledge of these interactions is being used to optimise the quality of intravenous anaesthesia. It is now known that propofol interferes with opioid metabolism, thereby increasing the plasma concentrations of the opioids, while opioi...<br/><br/>J Vuyk (1998) <i>Anaesthesia</i> <i></i> <i></i> 53 Suppl 1: 35-41<br/>

http://publicationslist.org/j.vuyk/refid29 2011-04-21T12:17:24Z

J Vuyk, M J Mertens, E Olofsen, A G Burm, J G Bovill (1997) <i>Anesthesiology</i> <i></i> <i></i> 87: 6 1549-1562<br/>

http://publicationslist.org/j.vuyk/refid30 2011-04-21T12:17:24Z

The pharmacokinetic and pharmacodynamic interactions between opioids and propofol increasingly have been described and used in clinical practice. It is now known that propofol inhibits both alfentanil and sufentanil metabolism, thereby increasing the plasma concentrations of these opioids, while alfentanil also elevates propofol concentrations. Pharmacodynamically the interaction between propofol ...<br/><br/>J Vuyk (1997) <i>J Clin Anesth</i> <i></i> <i></i> 9: 6 Suppl 23S-26S<br/>

http://publicationslist.org/j.vuyk/refid31 2011-04-21T12:17:24Z

Propofol and alfentanil often are combined during induction of anesthesia. However, the interaction between these agents during induction has not been studied in detail. The influence of alfentanil on the propofol concentration-effect relationships was studied for loss of eyelash reflex, loss of consciousness, and hemodynamic function in 20 unpremedicated ASA physical status 1 patients aged 20-55 ...<br/><br/>J Vuyk, F H Engbers, A G Burm, A A Vletter, G E Griever, E Olofsen, J G Bovill (1996) <i>Anesthesiology</i> <i></i> <i></i> 84: 2 288-299<br/>

http://publicationslist.org/j.vuyk/refid32 2011-04-21T12:17:24Z

Computer-controlled infusion of propofol is used with increasing frequency for the induction and maintenance of anesthesia. The performance of computer-controlled infusion devices is highly dependent on how well the implemented pharmacokinetic parameter set matches the pharmacokinetics of the patient. This study examined the performance of a computer-controlled infusion device when provided with f...<br/><br/>J Vuyk, F H Engbers, A G Burm, A A Vletter, J G Bovill (1995) <i>Anesth Analg</i> <i></i> <i></i> 81: 6 1275-1282<br/>

http://publicationslist.org/j.vuyk/refid33 2011-04-21T12:17:24Z

Propofol and alfentanil are frequently combined to provide general anesthesia. The purpose of this study was to characterize the pharmacodynamic interaction between propofol and alfentanil for several clinically relevant end points.<br/><br/>J Vuyk, T Lim, F H Engbers, A G Burm, A A Vletter, J G Bovill (1995) <i>Anesthesiology</i> <i></i> <i></i> 83: 1 8-22<br/>

http://publicationslist.org/j.vuyk/refid34 2011-04-21T12:17:24Z

Although propofol and alfentanil are given in combination in clinical practice, the pharmacodynamic interaction between these drugs has not been described.<br/><br/>J Vuyk, T Lim, F H Engbers, A G Burm, A A Vletter, J G Bovill (1993) <i>Anesthesiology</i> <i></i> <i></i> 78: 6 1036-45; discussion 23A<br/>

http://publicationslist.org/j.vuyk/refid35 2011-04-21T12:17:24Z

Although the clinical properties of propofol have been studied extensively, the pharmacodynamics have not yet been described fully. We studied the propofol concentration-effect relationships for loss of eyelash reflex, loss of consciousness, and hemodynamic changes in 18 female patients, ASA physical status 1, aged 20-49 yr. Propofol was given by computer-controlled infusion. The initial target co...<br/><br/>J Vuyk, F H Engbers, H J Lemmens, A G Burm, A A Vletter, M P Gladines, J G Bovill (1992) <i>Anesthesiology</i> <i></i> <i></i> 77: 1 3-9<br/>

http://publicationslist.org/j.vuyk/refid36 2011-04-21T12:17:24Z

Hemodynamic function during induction of anesthesia, the alfentanil and naloxone requirements, and the speed of recovery from total intravenous anesthesia with alfentanil/midazolam (group M, n = 10) or alfentanil/propofol (group P, n = 10) were compared in patients undergoing lower limb surgery. Twenty patients were randomly assigned to receive either 2 mg/kg propofol in 5 min followed by 9 mg.kg-...<br/><br/>J Vuyk, P J Hennis, A G Burm, J W de Voogt, J Spierdijk (1990) <i>Anesth Analg</i> <i></i> <i></i> 71: 6 645-650<br/>

http://publicationslist.org/j.vuyk/refid37 2011-04-21T12:17:24Z

The anesthesiologist attempts to balance the dose or concentration of an anesthetic against the intensity of noxious stimulation so as to: 1) maintain a satisfactory anesthetic state, 2) minimize side effects and toxicity of the anesthetic, and 3) allow for a rapid recovery from anesthesia. The development of infusion pumps controlled by computers programmed according to pharmacokinetic principles...<br/><br/>M E Ausems, J Vuyk, C C Hug, D R Stanski (1988) <i>Anesthesiology</i> <i></i> <i></i> 68: 6 851-861<br/>