http://publicationslist.org/data/jagadeesh.bayry/atom.xml Jagadeesh Bayryhttp://publicationslist.org/jagadeesh.bayry$basepathfavicon.icoRecent additions to Jagadeesh Bayry's PublicationsList.org pagehttp://publicationslist.org/publications.png2008-05-26T15:24:57Z http://publicationslist.org/jagadeesh.bayry/refid4 2008-05-26T15:24:44Z

Jagadeesh Bayry, Darren R Flower, David F Tough, Srini V Kaveri (2008) <i>Nat Rev Microbiol</i> <i></i> <i></i> 6: 1 <br/>

http://publicationslist.org/jagadeesh.bayry/refid8 2008-05-26T15:24:44Z

The clinical use of intravenous immunoglobulin (IVIg) based on its immunomodulatory and anti-inflammatory potential remains an ongoing challenge. Fcgamma receptor-mediated effects of IVIg, although well elucidated in certain pathologies, cannot entirely account for its proven benefit in several autoimmune disorders mediated by autoreactive T cells. In this study, we show that prophylactic infusion...<br/><br/>Amal Ephrem, Souleima Chamat, Catherine Miquel, Sylvain Fisson, Luc Mouthon, Giuseppina Caligiuri, Sandrine Delignat, Sriramulu Elluru, Jagadeesh Bayry, Sebastien Lacroix-Desmazes, José L Cohen, Benoît L Salomon, Michel D Kazatchkine, Srini V Kaveri, Namita Misra (2008) <i>Blood</i> <i></i> <i></i> 111: 2 715-722<br/>

http://publicationslist.org/jagadeesh.bayry/refid3 2008-05-26T15:24:44Z

BACKGROUND: The development of factor VIII (FVIII) inhibitors remains the major hurdle in the clinical management of patients with hemophilia A. FVIII uptake by professional antigen-presenting cells (APC) is the first step involved in initiation of immune responses to FVIII. Studies on FVIII catabolism have highlighted the role played by CD91/LRP as a potential target for increasing FVIII half-lif...<br/><br/>Suryasarathi Dasgupta, Ana Maria Navarrete, Sebastien André, Bharath Wootla, Sandrine Delignat, Yohann Repessé, Jagadeesh Bayry, Antonino Nicoletti, Evgueni L Saenko, Roseline d'Oiron, Marc Jacquemin, Jean-Marie Saint-Remy, Srini V Kaveri, Sebastien Lacroix-Desmazes (2008) <i>Haematologica</i> <i></i> <i></i> 93: 1 83-89<br/>

http://publicationslist.org/jagadeesh.bayry/refid5 2008-05-26T15:24:44Z

Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Suryasarathi Dasgupta, Michel D Kazatchkine, Srini V Kaveri (2008) <i>Nat Rev Immunol</i> <i></i> <i></i> 8: 1 <br/>

http://publicationslist.org/jagadeesh.bayry/refid1 2008-05-26T15:24:44Z

Acquired hemophilia is a rare hemorrhagic disorder caused by the spontaneous appearance of inhibitory autoantibodies directed against endogenous coagulation factor VIII (FVIII). Inhibitory Abs also arise in patients with congenital hemophilia A as alloantibodies directed to therapeutic FVIII. Both autoimmune and alloimmune inhibitors neutralize FVIII by steric hindrance. We have described FVIII-hy...<br/><br/>Bharath Wootla, Suryasarathi Dasgupta, Jordan D Dimitrov, Jagadeesh Bayry, Hervé Lévesque, Jeanne-Yvonne Borg, Annie Borel-Derlon, Desirazu N Rao, Alain Friboulet, Srinivas V Kaveri, Sébastien Lacroix-Desmazes (2008) <i>J Immunol</i> <i></i> <i></i> 180: 11 7714-7720<br/>

http://publicationslist.org/jagadeesh.bayry/refid2 2008-05-26T15:24:44Z

Pro-coagulant factor VIII (FVIII) is either produced endogenously under physiological conditions, or administered exogenously as a therapeutic hemostatic drug in patients with hemophilia A. In the circulation, FVIII interacts with a multitude of glycoproteins, and may be used for coagulation at the sites of bleeding, eliminated by scavenger cells or be processed by the immune system, either as a s...<br/><br/> Lacroix-Desmazes, Navarrete, Andre, Bayry, Kaveri, Dasgupta (2008) <i>Blood</i> <i></i> <i></i> : <br/>

http://publicationslist.org/jagadeesh.bayry/refid12 2008-05-26T15:24:44Z

Interactions between dendritic cells (DC) and T cells are known to involve the delivery of signals in both directions. We sought to characterize the effects on human DC of contact with different subsets of activated CD4+ T cells. The results showed that interaction with CD25(high)CD4+ regulatory T cells (Tregs) caused DC to take on very different properties than contact with naive or memory phenot...<br/><br/>Jagadeesh Bayry, Frédéric Triebel, Srini V Kaveri, David F Tough (2007) <i>J Immunol</i> <i></i> <i></i> 178: 7 4184-4193<br/>

http://publicationslist.org/jagadeesh.bayry/refid13 2008-05-26T15:24:44Z

Initially used as a replacement therapy for immunodeficiency diseases, intravenous immunoglobulin (IVIg) is now widely used for a number of autoimmune and inflammatory diseases. Considerable progress has been made in understanding the mechanisms by which IVIg exerts immunomodulatory effects in autoimmune and inflammatory disorders. The mechanisms of action of IVIg are complex, involving modulation...<br/><br/>Vir-Singh Negi, Sriramulu Elluru, Sophie Sibéril, Stéphanie Graff-Dubois, Luc Mouthon, Michel D Kazatchkine, Sébastien Lacroix-Desmazes, Jagadeesh Bayry, Srini V Kaveri (2007) <i>J Clin Immunol</i> <i></i> <i></i> 27: 3 233-245<br/>

http://publicationslist.org/jagadeesh.bayry/refid15 2008-05-26T15:24:44Z

Jordan D Dimitrov, Jagadeesh Bayry, Sophie Sibéril, Srini V Kaveri (2007) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 22: 5 1301-1304<br/>

http://publicationslist.org/jagadeesh.bayry/refid11 2008-05-26T15:24:44Z

Advances in our understanding of the pathogenesis of rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus have led to the emergence of immunoglobulin-based therapy as a major therapeutic force. Numerous monoclonal antibodies that target proinflammatory cytokines or their receptors (e.g. infliximab, adalimumab, tocilizumab, belimumab, HuMax-IL-15), and cell-surface or co...<br/><br/>Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Michel D Kazatchkine, Srini V Kaveri (2007) <i>Nat Clin Pract Rheumatol</i> <i></i> <i></i> 3: 5 262-272<br/>

http://publicationslist.org/jagadeesh.bayry/refid17 2008-05-26T15:24:44Z

Von Willebrand factor (VWF) is a chaperone molecule for procoagulant factor VIII (FVIII). Its role in the reduction of the immunogenicity of therapeutic FVIII in patients with hemophilia A has been evoked but lacks clear cellular and molecular rationale. Here, we demonstrate that VWF protects FVIII from being endocytosed by human dendritic cells (DCs) and subsequently presented to FVIII-specific T...<br/><br/>Suryasarathi Dasgupta, Yohann Repessé, Jagadeesh Bayry, Ana-Maria Navarrete, Bharath Wootla, Sandrine Delignat, Theano Irinopoulou, Caroline Kamaté, Jean-Marie Saint-Remy, Marc Jacquemin, Peter J Lenting, Annie Borel-Derlon, Srinivas V Kaveri, Sébastien Lacroix-Desmazes (2007) <i>Blood</i> <i></i> <i></i> 109: 2 610-612<br/>

http://publicationslist.org/jagadeesh.bayry/refid14 2008-05-26T15:24:44Z

Jagadeesh Bayry, Michel D Kazatchkine, Srini V Kaveri (2007) <i>Nat Clin Pract Neurol</i> <i></i> <i></i> 3: 3 120-121<br/>

http://publicationslist.org/jagadeesh.bayry/refid10 2008-05-26T15:24:44Z

Several therapeutic self-proteins elicit immune responses when administered to patients. Such adverse immune responses reduce drug efficacy. To induce an immune response, a protein must interact with different immune cells, including antigen-presenting cells, T cells, and B cells. Each cell type recognizes distinct immunogenic patterns on antigens. Mannose-terminating glycans have been identified ...<br/><br/>Suryasarathi Dasgupta, Ana-Maria Navarrete, Jagadeesh Bayry, Sandrine Delignat, Bharath Wootla, Sébastien André, Olivier Christophe, Michelina Nascimbeni, Marc Jacquemin, Luisa Martinez-Pomares, Teunis B H Geijtenbeek, Arnaud Moris, Jean-Marie Saint-Remy, Michel D Kazatchkine, Srinivas V Kaveri, Sébastien Lacroix-Desmazes (2007) <i>Proc Natl Acad Sci U S A</i> <i></i> <i></i> 104: 21 8965-8970<br/>

http://publicationslist.org/jagadeesh.bayry/refid6 2008-05-26T15:24:44Z

Von Willebrand factor (VWF) has been proposed to reduce the immunogenicity of therapeutic factor VIII (FVIII) in patients with hemophilia A. Using FVIII-deficient mice, we compared the immunogenicity of different preparations of plasma-derived (pd) and recombinant (r) FVIII. Treatment of mice with pdFVIII induced significantly lower titers of FVIII inhibitors, as measured by ELISA and in vitro coa...<br/><br/>Sandrine Delignat, Suryasarathi Dasgupta, Sébastien André, Ana-Maria Navarrete, Srinivas V Kaveri, Jagadeesh Bayry, Marie-Hélène André, Sami Chtourou, Zéra Tellier, Sébastien Lacroix-Desmazes (2007) <i>Haematologica</i> <i></i> <i></i> 92: 10 1423-1426<br/>

http://publicationslist.org/jagadeesh.bayry/refid7 2008-05-26T15:24:44Z

Jagadeesh Bayry, Srini V Kaveri, David F Tough (2007) <i>Arthritis Rheum</i> <i></i> <i></i> 56: 11 3874-3876<br/>

http://publicationslist.org/jagadeesh.bayry/refid9 2008-05-26T15:24:44Z

CD4+CD25+ regulatory T cells (Tregs) play a crucial role in controlling the development of autoimmune diseases such as rheumatoid arthritis (RA). However, despite an increased number of Tregs, the persistence of inflammation in the rheumatoid joints suggests that Tregs are unable to suppress ongoing disease, perhaps due to an inhibition of their functions by pro-inflammatory cytokines. Treatment o...<br/><br/> Bayry, Sibéril, Triebel, Tough, Kaveri (2007) <i>Drug Discov Today</i> <i></i> <i></i> 12: 13-14 548-552<br/>

http://publicationslist.org/jagadeesh.bayry/refid22 2008-05-26T15:24:44Z

Viscum album (VA) preparations consist of aqueous extracts of different types of lectins of mistletoe. VA exert cytotoxic and immunomodulatory properties that may be relevant for the inhibition of tumor growth. We addressed the effects of VA preparation VA Qu FrF on growth of B16F1 melanoma implanted in mice and on proliferation and cytokine synthesis of splenocytes. In C57BL6 mice, inhibition of ...<br/><br/>Jean-Paul Duong Van Huyen, Sandrine Delignat, Jagadeesh Bayry, Michel D Kazatchkine, Patrick Bruneval, Antonino Nicoletti, Srini V Kaveri (2006) <i>Cancer Lett</i> <i></i> <i></i> 243: 1 32-37<br/>

http://publicationslist.org/jagadeesh.bayry/refid21 2008-05-26T15:24:44Z

Despite several decades of investigation, the manner in which foot-and-mouth disease virus (FMDV) interacts with the innate and adaptive immune compartments is not completely understood. The importance of elucidating this relationship is emphasized by the inability of current FMDV vaccines to provide long-term protection and the recent outbreaks of FMDV in formerly disease-free countries. Dendriti...<br/><br/>Jagadeesh Bayry, David F Tough (2006) <i>Trends Microbiol</i> <i></i> <i></i> 14: 8 346-347<br/>

http://publicationslist.org/jagadeesh.bayry/refid19 2008-05-26T15:24:44Z

Viscum album (VA) preparations (Iscador) consist of aqueous extracts from different types of European mistletoe. Biologically active components of VA extracts include mistletoe lectins (ML) and viscotoxins. The treatment with VA extracts or with purified ML has been shown to be associated with tumor regression in several in vivo experimental models of tumoral implantation. The mechanisms underlyin...<br/><br/>Sriramulu Elluru, Jean-Paul Duong Van Huyen, Sandrine Delignat, Fabienne Prost, Jagadeesh Bayry, Michel D Kazatchkine, Srini V Kaveri (2006) <i>Arzneimittelforschung</i> <i></i> <i></i> 56: 6A 461-466<br/>

http://publicationslist.org/jagadeesh.bayry/refid20 2008-05-26T15:24:44Z

Factor VIII (FVIII) inhibitors are anti-FVIII IgG that arise in up to 50% of the patients with hemophilia A, upon therapeutic administration of exogenous FVIII. Factor VIII inhibitors neutralize the activity of the administered FVIII by sterically hindering its interaction with molecules of the coagulation cascade, or by forming immune complexes with FVIII and accelerating its clearance from the c...<br/><br/>Sébastien Lacroix-Desmazes, Bharath Wootla, Suryasarathi Dasgupta, Sandrine Delignat, Jagadeesh Bayry, Joseph Reinbolt, Johan Hoebeke, Evgueni Saenko, Michel D Kazatchkine, Alain Friboulet, Olivier Christophe, Valakunja Nagaraja, Srini V Kaveri (2006) <i>J Immunol</i> <i></i> <i></i> 177: 2 1355-1363<br/>

http://publicationslist.org/jagadeesh.bayry/refid18 2008-05-26T15:24:44Z

Intravenous immunoglobulin (IVIG) is increasingly used in the treatment of diverse immune-mediated disorders. Since several preparations of IVIG are available for therapy, it is possible that different manufacturing processes might influence clinical efficacy of IVIG. An insight into the mechanisms of action of such different IVIG preparations is therefore necessary that will provide further guide...<br/><br/>Sriramulu Elluru, Jean-Paul Duong Van Huyen, Fabienne Prost, Sandrine Delignat, Jagadeesh Bayry, Amal Ephrem, Sophie Siberil, Namita Misra, Sebastien Lacroix-Desmzes, Michel D Kazatchkine, Srini V Kaveri (2006) <i>Immunol Lett</i> <i></i> <i></i> 107: 1 58-62<br/>

http://publicationslist.org/jagadeesh.bayry/refid16 2008-05-26T15:24:44Z

Jagadeesh Bayry, Srini V Kaveri (2006) <i>Nat Rev Microbiol</i> <i></i> <i></i> 4: 8 <br/>

http://publicationslist.org/jagadeesh.bayry/refid27 2008-05-26T15:24:44Z

Jagadeesh Bayry, David F Tough (2005) <i>Trends Immunol</i> <i></i> <i></i> 26: 5 238-9; discussion 239-41<br/>

http://publicationslist.org/jagadeesh.bayry/refid28 2008-05-26T15:24:44Z

Sepsis is the leading cause of death in intensive care units and results from a deleterious systemic host response to infection. Although initially perceived as potentially deleterious, catalytic antibodies have been proposed to participate in removal of metabolic wastes and protection against infection. Here we show that the presence in plasma of IgG endowed with serine protease-like hydrolytic a...<br/><br/>Sébastien Lacroix-Desmazes, Jagadeesh Bayry, Srini V Kaveri, David Hayon-Sonsino, Nithyananda Thorenoor, Julien Charpentier, Charles-Edouard Luyt, Jean-Paul Mira, Valakunja Nagaraja, Michel D Kazatchkine, Jean-François Dhainaut, Vincent O Mallet (2005) <i>Proc Natl Acad Sci U S A</i> <i></i> <i></i> 102: 11 4109-4113<br/>

http://publicationslist.org/jagadeesh.bayry/refid26 2008-05-26T15:24:44Z

Intravenous immunoglobulin (IVIg) has been used in the treatment of primary and secondary antibody deficiencies for over 25 years. It is a safe preparation with no long-term side effects. IVIg was first demonstrated to be effective in autoimmune disorders, two decades ago, in the treatment of acute immune thrombocytopenia. Since then, the therapeutic efficacy of IVIg has been established in Guilla...<br/><br/>Namita Misra, Jagadeesh Bayry, Amal Ephrem, Suryasarathi Dasgupta, Sandrine Delignat, Jean-Paul Duong Van Huyen, Fabienne Prost, Sebastien Lacroix-Desmazes, Antonino Nicoletti, Michel D Kazatchkine, Srini V Kaveri (2005) <i>J Neurol</i> <i></i> <i></i> 252 Suppl 1: I1-I6<br/>

http://publicationslist.org/jagadeesh.bayry/refid24 2008-05-26T15:24:44Z

Common variable immunodeficiency (CVID) is a heterogeneous disorder that is associated with low serum-immunoglobulin concentrations, defective specific-antibody production and an increased susceptibility to bacterial infections of the respiratory and gastrointestinal tracts. In spite of the identification of genes that are associated with several known primary immunodeficiencies, the basic immunol...<br/><br/>Jagadeesh Bayry, Olivier Hermine, David A Webster, Yves Lévy, Srini V Kaveri (2005) <i>Trends Mol Med</i> <i></i> <i></i> 11: 8 370-376<br/>

http://publicationslist.org/jagadeesh.bayry/refid29 2008-05-26T15:24:44Z

We describe the emergence of a nephropathogenic avian infectious bronchitis virus (IBV) with a novel genotype in India. The Indian IBV isolate exhibited a relatively high degree of sequence divergence with reference strains. The highest homology was observed with strain 6/82 (68%) and the least homology with strain Mex/1765/99 (34.3%).<br/><br/>Jagadeesh Bayry, Mallikarjun S Goudar, Prashant K Nighot, Supriya G Kshirsagar, Brian S Ladman, Jack Gelb, Govind R Ghalsasi, Gopal N Kolte (2005) <i>J Clin Microbiol</i> <i></i> <i></i> 43: 2 916-918<br/>

http://publicationslist.org/jagadeesh.bayry/refid23 2008-05-26T15:24:44Z

Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Olivier Hermine, Eric Oksenhendler, Michel D Kazatchkine, Srini V Kaveri (2005) <i>Am J Med</i> <i></i> <i></i> 118: 12 1439-1440<br/>

http://publicationslist.org/jagadeesh.bayry/refid25 2008-05-26T15:24:44Z

Investigating the signals that regulate the function of dendritic cells (DC), the sentinels of the immune system, is critical to understanding the role of DC in the regulation of immune responses. Accumulating lines of evidence indicate that in addition to innate stimuli and T cell-derived signals, B lymphocytes exert a profound regulatory effect in vitro and in vivo on the Ag-presenting function ...<br/><br/>Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Michel D Kazatchkine, Olivier Hermine, David F Tough, Srini V Kaveri (2005) <i>J Immunol</i> <i></i> <i></i> 175: 1 15-20<br/>

http://publicationslist.org/jagadeesh.bayry/refid30 2008-05-26T15:24:44Z

The differentiation and maturation of dendritic cells (DCs) is governed by various signals in the microenvironment. Monocytes and DCs circulate in peripheral blood, which contains high levels of natural antibodies (NAbs). NAbs are germ-line-encoded and occur in the absence of deliberate immunization or microbial aggression. To assess the importance of NAbs in the milieu on DC development, we exami...<br/><br/>Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Vladimira Donkova-Petrini, Cédric Carbonneil, Namita Misra, Yves Lepelletier, Sandrine Delignat, Sooryanarayana Varambally, Eric Oksenhendler, Yves Lévy, Marianne Debré, Michel D Kazatchkine, Olivier Hermine, Srini V Kaveri (2004) <i>Proc Natl Acad Sci U S A</i> <i></i> <i></i> 101: 39 14210-14215<br/>

http://publicationslist.org/jagadeesh.bayry/refid35 2008-05-26T15:24:44Z

Natural polyreactive IgM autoantibodies, encoded by unmutated germline Ig V genes, represent a major fraction of the normal circulating IgM repertoire. We have previously shown that therapeutic preparation of pooled IgM exerts immunomodulatory effects as assessed by in vitro and in vivo studies. Here, we show that the IgM preparation induces cell death in lymphoblastoid cell lines and in human per...<br/><br/>Sooryanarayana Varambally, Yaron Bar-Dayan, Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Michael Horn, Marc Sorel, Yosefa Bar-Dayan, Giovina Ruberti, Michel D Kazatchkine, Srini V Kaveri (2004) <i>Int Immunol</i> <i></i> <i></i> 16: 3 517-524<br/>

http://publicationslist.org/jagadeesh.bayry/refid33 2008-05-26T15:24:44Z

Dendritic cells (DC) are professional antigen-presenting cells that are specialized in the uptake of antigens and their transport from peripheral tissues to the lymphoid organs. Because of their capacity to stimulate naive T cells, DC have a central role in the initiation of primary immune responses and are considered promising tools and targets for immunotherapy. Emerging data suggest a role for ...<br/><br/>Jagadeesh Bayry, Marina Thirion, Sandrine Delignat, Namita Misra, Sébastien Lacroix-Desmazes, Michel D Kazatchkine, Srini V Kaveri (2004) <i>Autoimmun Rev</i> <i></i> <i></i> 3: 3 183-187<br/>

http://publicationslist.org/jagadeesh.bayry/refid34 2008-05-26T15:24:44Z

The characteristics and functions of CD4(+)CD25(+) regulatory cells have been well defined in murine and human systems. However, the interaction between CD4(+)CD25(+) T cells and dendritic cells (DC) remains unclear. In this study, we examined the effect of human CD4(+)CD25(+) T cells on maturation and function of monocyte-derived DC. We show that regulatory T cells render the DC inefficient as AP...<br/><br/>Namita Misra, Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Michel D Kazatchkine, Srini V Kaveri (2004) <i>J Immunol</i> <i></i> <i></i> 172: 8 4676-4680<br/>

http://publicationslist.org/jagadeesh.bayry/refid32 2008-05-26T15:24:44Z

The dramatic increase in both the number of novel infectious agents and resistance to antimicrobial drugs has incited the need for adjunct therapies in the war against infectious diseases. Exciting recent studies have demonstrated the use of antibodies in the form of intravenous immunoglobulin (IVIg) against infections. By virtue of the diverse repertoire of immunoglobulins that possess a wide spe...<br/><br/>Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Michel D Kazatchkine, Srini V Kaveri (2004) <i>Trends Pharmacol Sci</i> <i></i> <i></i> 25: 6 306-310<br/>

http://publicationslist.org/jagadeesh.bayry/refid31 2008-05-26T15:24:44Z

Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia and defects in T-cell functions that could be primary or secondary. We addressed whether CVID is associated with impairment in the dendritic cell (DC) compartment, as DCs play a central role in the development of adaptive immunity. We demonstrate that DCs from CVID patients display severely perturbed differentiation,...<br/><br/>Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Michel D Kazatchkine, Lionel Galicier, Yves Lepelletier, David Webster, Yves Lévy, Martha M Eibl, Eric Oksenhendler, Olivier Hermine, Srini V Kaveri (2004) <i>Blood</i> <i></i> <i></i> 104: 8 2441-2443<br/>

http://publicationslist.org/jagadeesh.bayry/refid42 2008-05-26T15:24:44Z

Hemophilia A is an X-linked, recessive, bleeding disorder caused by defective or deficient factor VIII (FVIII) molecules. Infusion of purified FVIII to patients with severe hemophilia A results in approximately 25% of the cases, in the emergence of anti-FVIII antibodies (inhibitors) that are known to neutralize the pro-coagulant activity of FVIII by steric hindrance. We recently reported on the pr...<br/><br/>Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Anastas Pashov, Dorothea Stahl, Johan Hoebeke, Michel D Kazatchkine, Srini V Kaveri (2003) <i>Autoimmun Rev</i> <i></i> <i></i> 2: 1 30-35<br/>

http://publicationslist.org/jagadeesh.bayry/refid43 2008-05-26T15:24:44Z

Sébastien Lacroix-Desmazes, Jagadeesh Bayry, Michel D Kazatchkine, Srini V Kaveri (2003) <i>Med Sci (Paris)</i> <i></i> <i></i> 19: 5 519-522<br/>

http://publicationslist.org/jagadeesh.bayry/refid48 2008-05-26T15:24:44Z

Normal immunoglobulin G for therapeutic use (intravenous immunoglobulin [IVIg]) is used in an increasing number of immune-mediated conditions, including acute and chronic/relapsing autoimmune diseases, transplantation, and systemic inflammatory disorders. Several mutually nonexclusive mechanisms of action account for the immunoregulatory effects of IVIg. Although IVIg inhibits T-cell proliferation...<br/><br/>Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Cedric Carbonneil, Namita Misra, Vladimira Donkova, Anastas Pashov, Alain Chevailler, Luc Mouthon, Bernard Weill, Patrick Bruneval, Michel D Kazatchkine, Srini V Kaveri (2003) <i>Blood</i> <i></i> <i></i> 101: 2 758-765<br/>

http://publicationslist.org/jagadeesh.bayry/refid40 2008-05-26T15:24:44Z

Natural autoantibodies (NAbs), produced by B-1 B-cells, are directed against autoantigens and pathogens. NAbs can capture and present antigen to T helper cells thereby initiating adaptive immunities. It is proposed that screening for NAbs against pathogens will predict the strength of an antigen-induced immune response and could be used as a tool for vaccine development.<br/><br/>H Kohler, J Bayry, A Nicoletti, S V Kaveri (2003) <i>Scand J Immunol</i> <i></i> <i></i> 58: 3 285-289<br/>

http://publicationslist.org/jagadeesh.bayry/refid44 2008-05-26T15:24:44Z

Therapeutic polyclonal intravenous immunoglobulin (IVIg) consists of normal IgG obtained from the pools of plasma of several thousand healthy blood donors. IVIg is used as substitutive treatment of primary and secondary immunodeficiences. Since the first study of Paul Imbach who demonstrated the beneficial effect in idiopathic thrombocytopenic purpura, IVIg is also used in a number of autoimmune a...<br/><br/>J Bayry, N Misra, V Latry, F Prost, S Delignat, S Lacroix-Desmazes, M D Kazatchkine, S V Kaveri (2003) <i>Transfus Clin Biol</i> <i></i> <i></i> 10: 3 165-169<br/>

http://publicationslist.org/jagadeesh.bayry/refid36 2008-05-26T15:24:44Z

OBJECTIVE: Alterations in the function of dendritic cells (DCs) may explain the systemic autoimmune responses that characterize systemic lupus erythematosus (SLE). Even though several reports have documented the beneficial effect of intravenous immunoglobulin (IVIG) in SLE, the underlying mechanisms of action remain poorly understood. Considering the effect of serum factors, including interferon-a...<br/><br/>Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Sandrine Delignat, Luc Mouthon, Bernard Weill, Michel D Kazatchkine, Srini V Kaveri (2003) <i>Arthritis Rheum</i> <i></i> <i></i> 48: 12 3497-3502<br/>

http://publicationslist.org/jagadeesh.bayry/refid37 2008-05-26T15:24:44Z

Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Michel D Kazatchkine, Srini V Kaveri (2003) <i>J Infect Dis</i> <i></i> <i></i> 188: 10 1610; author reply 1610-1610; author reply 1611<br/>

http://publicationslist.org/jagadeesh.bayry/refid38 2008-05-26T15:24:44Z

Intravenous immunoglobulins (IVIg) exert a broad range of immunoregulatory functions that provide a basis for the beneficial effects of IVIg in autoimmune and systemic inflammatory disorders. This review focuses on the effects f IVIg on humoral and cellular immunity that may be of relevance for the treatment of inflammatory neurological diseases.<br/><br/>J Bayry, M Thirion, N Misra, N Thorenoor, S Delignat, S Lacroix-Desmazes, B Bellon, S Kaveri, M D Kazatchkine (2003) <i>Neurol Sci</i> <i></i> <i></i> 24 Suppl 4: S217-S221<br/>

http://publicationslist.org/jagadeesh.bayry/refid39 2008-05-26T15:24:44Z

In the present study, we have analyzed the T cell receptor (TCR) repertoires of CD4+ T cells isolated from peripheral blood of 10 inhibitor-positive patients with severe hemophilia A. The distribution of complementarity determining region (CDR3) lengths of the beta chain of the TCRs was analyzed by spectratyping prior to and following in vitro stimulation of the cells with human factor VIII (FVIII...<br/><br/>Namita Misra, Jagadeesh Bayry, Anastas Pashov, Srini V Kaveri, Roseline D'Oiron, Natalie Stieltjes, Valeri Roussel-Robert, Michel D Kazatchkine, Olivier Boyer, Sébastien Lacroix-Desmazes (2003) <i>Thromb Haemost</i> <i></i> <i></i> 90: 5 813-822<br/>

http://publicationslist.org/jagadeesh.bayry/refid51 2008-05-26T15:24:44Z

The epidemiological role of small ruminants in foot-and-mouth disease (FMD) outbreaks has been generally neglected. Although, the disease in these species is sub-clinical in nature, their role as virus carriers represents a reservoir for further infection and spread of disease. Data on the usefulness of polyvalent FMD vaccine (FMDV) in goats is scant. Thus, the present study was undertaken to eval...<br/><br/>P K Patil, J Bayry, C Ramakrishna, B Hugar, L D Misra, C Natarajan (2002) <i>Vaccine</i> <i></i> <i></i> 20: 21-22 2781-2789<br/>

http://publicationslist.org/jagadeesh.bayry/refid52 2008-05-26T15:24:44Z

The occurrence of factor VIII (FVIII) inhibitors is one of the major complications of the treatment of haemophilia A. We present this review as a description of the major players of the antiFVIII immune response, with particular emphasis on the nature and properties of the different antiFVIII antibodies, their mechanisms of action in inhibiting FVIII activity, their potential neutralization by ant...<br/><br/>S Lacroix-Desmazes, N Misra, J Bayry, C Artaud, B Drayton, S V Kaveri, M D Kazatchkine (2002) <i>Haemophilia</i> <i></i> <i></i> 8: 3 273-279<br/>

http://publicationslist.org/jagadeesh.bayry/refid54 2008-05-26T15:24:44Z

BACKGROUND: Factor VIII inhibitors are IgG alloantibodies that arise during replacement therapy in 25 to 50 percent of patients with severe hemophilia A. The hydrolysis of factor VIII by anti--factor VIII antibodies has been proposed as a mechanism of inactivation of factor VIII. METHODS: We purified IgG from patients with severe hemophilia A. The proteolytic activity of the antibodies was assesse...<br/><br/>Sébastien Lacroix-Desmazes, Jagadeesh Bayry, Namita Misra, Michael P Horn, Sylvie Villard, Anastas Pashov, Natalie Stieltjes, Roseline d'Oiron, Jean-Marie Saint-Remy, Johan Hoebeke, Michel D Kazatchkine, Joseph Reinbolt, Dipika Mohanty, Srini V Kaveri (2002) <i>N Engl J Med</i> <i></i> <i></i> 346: 9 662-667<br/>

http://publicationslist.org/jagadeesh.bayry/refid55 2008-05-26T15:24:44Z

Vaccine against foot-and-mouth disease (FMD) is prepared after inactivating the virus produced in cell culture. Inactivation of the FMD virus (FMDV) was earlier done by formaline. However, several vaccine outbreaks, which occurred in Europe revealed that the formaline treatment is not highly effective for virus inactivation. Subsequently, binary ethyleneimine (BEI) was identified as an effective i...<br/><br/>P K Patil, V Suryanarayana, Pradeep Bist, Jagdeesh Bayry, C Natarajan (2002) <i>Vaccine</i> <i></i> <i></i> 20: 7-8 1163-1168<br/>

http://publicationslist.org/jagadeesh.bayry/refid50 2008-05-26T15:24:44Z

Foot-and-mouth disease (FMD) is an economically important disease of cloven-hoofed animals. The multiplicity of FMDV serotypes in animals poses a central problem in the policy of vaccination and is of much concern to health authorities. Hence it is the practice of vaccination with polyvalent vaccine for prophylactic measure. In the present report, we analysed the early antibody responses elicited ...<br/><br/>P K Patil, J Bayry, S P Nair, S Gopalakrishna, C M Sajjanar, L D Misra, C Natarajan (2002) <i>Vet Microbiol</i> <i></i> <i></i> 87: 2 103-109<br/>

http://publicationslist.org/jagadeesh.bayry/refid53 2008-05-26T15:24:44Z

Idiotypic vaccination has proven successful in several animal models and human trials. Here we suggest that the expression of cross-reactive idiotypes on factor VIII (FVIII) inhibitors of patients with haemophilia A, patients with anti-FVIII autoimmune disease and natural anti-FVIII antibodies of healthy individuals, together with the ability of anti-idiotypic reagents to neutralize anti-FVIII ant...<br/><br/>S Lacroix-Desmazes, J Bayry, N Misra, S V Kaveri, M D Kazatchkine (2002) <i>Haemophilia</i> <i></i> <i></i> 8 Suppl 2: 55-59<br/>

http://publicationslist.org/jagadeesh.bayry/refid49 2008-05-26T15:24:44Z

Antibodies endowed with hydrolytic properties have been described in humans for over a decade in a variety of pathological conditions such as systemic lupus erythematosus (SLE), autoimmune thyroiditis, asthma, and Bence Jones disease. Although the identified target substrate molecules have always been autoantigens (i.e., DNA, thyroglobulin, vasoactive intestinal peptide), a direct role of hydrolys...<br/><br/>Sébastien Lacroix-Desmazes, Namita Misra, Jagadeesh Bayry, Sylvie Villard, Michel D Kazatchkine, Srinivas V Kaveri (2002) <i>J Immunol Methods</i> <i></i> <i></i> 269: 1-2 251-256<br/>

http://publicationslist.org/jagadeesh.bayry/refid41 2008-05-26T15:24:44Z

Anti-Factor VIII (FVIII) antibodies represent a unique model to study the relationship between natural autoreactivity (natural antibodies to FVIII of healthy individuals) and disease-associated autoimmunity ('spontaneous' FVIII inhibitors of patients with anti-FVIII autoimmune disease) to a single human protein antigen. Although natural and disease-associated anti-FVIII antibodies are not readily ...<br/><br/>Sébastien Lacroix-Desmazes, Namita Misra, Jagadeesh Bayry, Dipika Mohanty, Srini V Kaveri, Michel D Kazatchkine (2002) <i>Autoimmun Rev</i> <i></i> <i></i> 1: 1-2 105-110<br/>

http://publicationslist.org/jagadeesh.bayry/refid47 2008-05-26T15:24:44Z

Despite representing the majority of the world's foot-and-mouth disease (FMD)-susceptible livestock, sheep and goats have generally been neglected with regard to their epidemiological role in the spread of FMD. In the present investigations, FMD virus quadrivalent double emulsion (Montanide ISA 206) vaccines were tested in sheep. The oil adjuvant elicited a better immune response at any time than ...<br/><br/>Prasanna K Patil, Jagadeesh Bayry, Chitimalla Ramakrishna, Basavesh Hugar, Laxmi D Misra, Krishnamsetty Prabhudas, C Natarajan (2002) <i>J Clin Microbiol</i> <i></i> <i></i> 40: 11 4367-4371<br/>

http://publicationslist.org/jagadeesh.bayry/refid45 2008-05-26T15:24:44Z

Jagadeesh Bayry, Anastas Pashov, Vladimira Donkova, Sandrine Delignat, Tchavdar Vassilev, Dorothea Stahl, Blache Bellon, Michel D Kazatchkine, Sébastien Lacroix-Desmazes, Srini V Kaveri (2002) <i>Vox Sang</i> <i></i> <i></i> 83 Suppl 1: 49-52<br/>

http://publicationslist.org/jagadeesh.bayry/refid46 2008-05-26T15:24:44Z

BACKGROUND: Viscum album (VA) preparations consist of aqueous extracts of different types of lectins of VA. Mistletoe lectins have both cytotoxic and immunomodulatory properties that support their study for the development for cancer therapy. However, the mechanisms of the anti- tumoral properties in vivo of mistletoe lectins are not fully understood. Because endothelial cells (EC) play a pivotal ...<br/><br/>Jean-Paul Duong Van Huyen, Jagadeesh Bayry, Sandrine Delignat, Anh Thu Gaston, Odile Michel, Patrick Bruneval, Michel D Kazatchkine, Antonino Nicoletti, Srini V Kaveri (2002) <i>Mol Med</i> <i></i> <i></i> 8: 10 600-606<br/>

http://publicationslist.org/jagadeesh.bayry/refid56 2008-05-26T15:24:44Z

J Bayry, S V Kaveri (2001) <i>J Clin Microbiol</i> <i></i> <i></i> 39: 10 <br/>

http://publicationslist.org/jagadeesh.bayry/refid58 2008-05-26T15:24:44Z

The specificity of foot and mouth disease virus (FMDV) serological tests depends largely on the quality and purity of the antibodies used. Such type specific antibodies can be generated by hybridoma technology. Alternatively, the specific antibodies can be selected from polyclonal serum by immunoaffinity chromatography using recombinant protein/peptide bound affinity matrices. Based on this approa...<br/><br/>J Bayry, K Prabhudas, P Bist, G R Reddy, V V Suryanarayana (1999) <i>J Virol Methods</i> <i></i> <i></i> 81: 1-2 21-30<br/>

http://publicationslist.org/jagadeesh.bayry/refid59 2008-05-26T15:24:44Z

J Bayry, K Prabhudas, V V Suryanarayana (1999) <i>Vaccine</i> <i></i> <i></i> 17: 19 2333-2334<br/>

http://publicationslist.org/jagadeesh.bayry/refid57 2008-05-26T15:24:44Z

Recombinant protein of Foot and Mouth Disease Virus (FMDV) type Asia 1 corresponding to the C-terminal half of VP1 was expressed in Escherichia coli. As an alternative to the synthetic peptide, this selected C-terminal region was used as a protein vaccine in guinea pigs in order to study the immune response with various adjuvant formulations: immune stimulatory complexes (ISCOMs), Montanide ISA 20...<br/><br/>J Bayry, K Prabhudas, S Gopalakrishna, P K Patil, C Ramakrishna, L D Misra, V V Suryanarayana (1999) <i>Microbiol Immunol</i> <i></i> <i></i> 43: 8 765-771<br/>