http://publicationslist.org/data/jasmin.bektic/atom.xml Jasmin Bektichttp://publicationslist.org/jasmin.bektic$basepathfavicon.icoRecent additions to Jasmin Bektic's PublicationsList.org pagehttp://publicationslist.org/publications.png2016-05-10T12:21:13Z http://publicationslist.org/jasmin.bektic/refid58 2016-05-10T12:19:31Z

Experience from interdisciplinary cooperation revealed the need for a prostate mapping scheme to communicate multiparametric MRI (mpMRI) findings between radiologists, urologists, and pathologists, which should be detailed, yet easy to memorize. For this purpose, the 'Prostate interdisciplinary communication and mapping algorithm for biopsy and pathology' (PIC-MABP) was developed. This study evalu...<br/><br/>Daniel Junker, Thomas R W Herrmann, Markus Bader, Jasmin Bektic, Gregor Henkel, Stephan Kruck, Markus Sandbichler, David Schilling, Georg Schäfer, Udo Nagele, (2016) <i>World journal of urology</i> <i></i> <i></i> 34: 2 245-252<br/>

http://publicationslist.org/jasmin.bektic/refid55 2016-05-10T12:19:31Z

In recent years, new therapeutic options have brought improvements in the treatment of metastatic, castration-resistant prostate cancer. Targeted Hormone Therapy (THT) represents a novel therapeutic component for which recent studies have shown a maximum benefit in the time between failure of androgen deprivation therapy (patient is metastatic and still pain-free) and prior to chemotherapy. Prosta...<br/><br/>Anton Ponholzer, Wolfgang Loidl, Jasmin Bektic, Karl Dorfinger, Stephan Hruby, Klaus Jeschke, Gero Kramer, Steffen Krause, Georg Ludvik, Mesut Remzi, Michael Roider, Franz Stoiber (2016) <i>Wiener klinische Wochenschrift</i> <i></i> <i></i> 128: 3-4 156-163<br/>

http://publicationslist.org/jasmin.bektic/refid59 2016-05-10T12:19:31Z

Free prostate-specific antigen (fPSA) and its molecular isoforms are suggested for enhancement of PSA testing in prostate cancer (PCa). In the present study we evaluated whether PSA isoforms' velocities might serve as a tool to improve early PCa diagnosis. Our study population included 381 men who had undergone at least one ultrasound-guided prostate biopsy whose pathologic examination yielded PCa...<br/><br/>Isabel Heidegger, Helmut Klocker, Renate Pichler, Wolfgang Horninger, Jasmin Bektic (2015) <i>Anticancer research</i> <i></i> <i></i> 35: 6 3567-3570<br/>

http://publicationslist.org/jasmin.bektic/refid57 2016-05-10T12:19:31Z

To reduce the number of unnecessary biopsies in patients with benign prostatic disease, however, without missing significant PCa the present study re-evaluates the age-dependent PSA cut-offs in the Tyrol Prostate Cancer (PCa) early detection program.<br/><br/>Isabel Heidegger, Josef Fritz, Helmut Klocker, Renate Pichler, Jasmin Bektic, Wolfgang Horninger (2015) <i>PloS one</i> <i></i> <i></i> 10: 7 <br/>

http://publicationslist.org/jasmin.bektic/refid56 2016-05-10T12:19:31Z

The study aims to identify candidates who can be managed conservatively after the first episode of spontaneous painful acute urinary retention (AUR).<br/><br/>Isabel Heidegger, Josef Fritz, Hannes Steiner, Jasmin Bektic, Renate Pichler (2015) <i>Urologia internationalis</i> <i></i> <i></i> : <br/>

http://publicationslist.org/jasmin.bektic/refid60 2016-05-10T12:19:31Z

To assess the association between PSA levels, PSA kinetics and other factors and a pathological (68)Ga-PSMA PET/CT scan in patients with recurrent prostate cancer (rPCa) with biochemical relapse (BR) after radical therapy.<br/><br/>Francesco Ceci, Christian Uprimny, Bernhard Nilica, Llanos Geraldo, Dorota Kendler, Alexander Kroiss, Jasmin Bektic, Wolfgang Horninger, Peter Lukas, Clemens Decristoforo, Paolo Castellucci, Stefano Fanti, Irene J Virgolini (2015) <i>European journal of nuclear medicine and molecular imaging</i> <i></i> <i></i> 42: 8 1284-1294<br/>

http://publicationslist.org/jasmin.bektic/refid61 2016-05-10T12:19:31Z

Active surveillance (AS) is increasingly offered to patients with low risk prostate cancer. The present study was conducted to evaluate the risk of tumor under-grading and -staging for AS eligibility. Moreover, we analyzed possible biomarkers for predicting more unfavorable final tumor histology.<br/><br/>Isabel Heidegger, Viktor Skradski, Eberhard Steiner, Helmut Klocker, Renate Pichler, Andreas Pircher, Wolfgang Horninger, Jasmin Bektic (2015) <i>PloS one</i> <i></i> <i></i> 10: 2 <br/>

http://publicationslist.org/jasmin.bektic/refid62 2016-05-10T12:19:31Z

To evaluate multiparametric magnetic resonance imaging/transrectal ultrasound (mpMRI/TRUS) fusion targeted biopsy (TB) of the prostate for prostate cancer (PCa) diagnosis.<br/><br/>Daniel Junker, Georg Schäfer, Isabel Heidegger, Jasmin Bektic, Michael Ladurner, Werner Jaschke, Friedrich Aigner (2015) <i>Urologia internationalis</i> <i></i> <i></i> 94: 3 313-318<br/>

http://publicationslist.org/jasmin.bektic/refid63 2016-05-10T12:19:31Z

Palpation of organs is one of the oldest clinical examination techniques, for instance, if you think of the palpation of the breast or the digital rectal examination of the prostate, where hard palpable regions are suspicious for cancer. This is the basic principle of real-time elastography, an ultrasound technique, which is able to visualise tissue elasticity. Since prostate cancer features an in...<br/><br/>D Junker, T De Zordo, M Quentin, M Ladurner, J Bektic, W Horniger, W Jaschke, F Aigner (2014) <i>BioMed research international</i> <i></i> <i></i> 2014: <br/>

http://publicationslist.org/jasmin.bektic/refid52 2014-03-24T21:04:05Z

Abiraterone acetate (AA) is a selective oral inhibitor of Steroid-17α-Hydroxylase, for patients with castration-resistant prostate cancer. Not all patients respond to therapy, however, there are no biomarkers predicting response to AA therapy. The aim of the present study was the identification of a biomarker for patients who are likely to respond to AA therapy.<br/><br/>Isabel Heidegger, Udo Nagele, Andreas Pircher, Renate Pichler, Wolfgang Horninger, Jasmin Bektic (2014) <i>Anticancer research</i> <i></i> <i></i> 34: 1 307-311<br/>

http://publicationslist.org/jasmin.bektic/refid54 2014-03-24T21:04:05Z

Anastomosing hemangioma of the kidney is a very rare neoplasm, currently 19 cases have been reported in the literature. First described in 2009, histopathologically anastomosing hemangioma is similar to aggressive angiosarcoma. No long-term follow-up data of anastomosing hemangioma have been described yet. Here, we present the case of a healthy 56-year-old man diagnosed in 2002 with a 7 × 5-c...<br/><br/>Isabel Heidegger, Renate Pichler, Georg Schäfer, Bernhard Zelger, Bettina Zelger, Friedrich Aigner, Jasmin Bektic, Wolfgang Horninger (2014) <i>International journal of urology : official journal of the Japanese Urological Association</i> <i></i> <i></i> : <br/>

http://publicationslist.org/jasmin.bektic/refid53 2014-03-24T21:04:05Z

OBJECTIVE. The purpose of this study was to compare prostate cancer detection rate of real-time elastography (RTE) with that of multiparametric MRI to evaluate the advantages and disadvantages of the two methods. SUBJECTS AND METHODS. Thirty-nine patients with biopsy-proven prostate cancer underwent both RTE and multiparametric MRI to localize prostate cancer before radical prostatectomy. RTE was ...<br/><br/>Daniel Junker, Georg Schäfer, Conrad Kobel, Christian Kremser, Jasmin Bektic, Werner Jaschke, Friedrich Aigner (2014) <i>AJR. American journal of roentgenology</i> <i></i> <i></i> 202: 3 W263-W269<br/>

http://publicationslist.org/jasmin.bektic/refid46 2013-07-21T17:51:39Z

WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Despite diverse anatomical and histological trials in humans and animal models, the aetiology of hypospadias remains unknown and currently there is no clear molecular explanation about the emergence of this disease; however, genetic, endocrine and environmental mechanisms have been suggested. The aim of the present study was to quantify an...<br/><br/>Renate Pichler, Gabriel Djedovic, Helmut Klocker, Isabel Heidegger, Alexander Strasak, Wolfgang Loidl, Jasmin Bektic, Viktor Skradski, Wolfgang Horninger, Josef Oswald (2013) <i>BJU international</i> <i></i> <i></i> 112: 2 265-270<br/>

http://publicationslist.org/jasmin.bektic/refid47 2014-01-07T10:04:19Z

Prostate cancer is a leading cause of cancer death in men in developed countries. Once the tumor has achieved a castration-refractory metastatic stage, treatment options are limited with the average survival of patients ranging from two to three years only. Recently, new drugs for treatment of castration-resistant prostate cancer (CRPC) have been approved, and others are in an advanced stage of cl...<br/><br/>Isabel Heidegger, Petra Massoner, Iris E Eder, Andreas Pircher, Renate Pichler, Friedrich Aigner, Jasmin Bektic, Wolfgang Horninger, Helmut Klocker (2013) <i>The Journal of steroid biochemistry and molecular biology</i> <i></i> <i></i> 138: 248-256<br/>

http://publicationslist.org/jasmin.bektic/refid45 2013-02-06T15:58:36Z

BACKGROUND:The TMPRSS2-ERG gene fusion resulting in ERG overexpression has been found in around 50% of prostate cancers (PCa) and is a very early event in tumorigenesis. Most studies have reported on selected surgical cohorts with inconsistent results. We hypothesized that ERG gene rearrangements impact tumor development and investigated the frequency of ERG overexpression in the context of clinic...<br/><br/>G Schaefer, J-M Mosquera, R Ramoner, K Park, A Romanel, E Steiner, W Horninger, J Bektic, M Ladurner-Rennau, M A Rubin, F Demichelis, H Klocker (2013) <i>Prostate Cancer Prostatic Dis</i> <i></i> <i></i> : <br/>

http://publicationslist.org/jasmin.bektic/refid51 2014-03-24T21:04:05Z

To evaluate the ESUR scoring system (PI-RADS) for multiparametric MRI of the prostate in clinical routine and to define a reliable way to generate an overall PI-RADS score.<br/><br/>Daniel Junker, Georg Schäfer, Michael Edlinger, Christian Kremser, Jasmin Bektic, Wolfgang Horninger, Werner Jaschke, Friedrich Aigner (2013) <i>BioMed research international</i> <i></i> <i></i> 2013: <br/>

http://publicationslist.org/jasmin.bektic/refid50 2014-01-07T10:04:19Z

Background:The aim of the study was to evaluate the correlation between preoperative [-2]proPSA, the Gleason Score (GS) and the risk of non-organ-confined (NOC) disease in patients undergoing radical prostatectomy (RP).Methods:Beckman Coulter Access immunoassay was used to study serum specimens of 381 patients enrolled in a prostate cancer (PCa) early detection program. Inclusion criteria were thr...<br/><br/>I Heidegger, H Klocker, E Steiner, V Skradski, M Ladurner, R Pichler, G Schäfer, W Horninger, J Bektic (2013) <i>Prostate cancer and prostatic diseases</i> <i></i> <i></i> : <br/>

http://publicationslist.org/jasmin.bektic/refid49 2014-01-07T10:04:19Z

Aim: To evaluate the role of repeated urological evaluation after negative initial diagnostic work-up of asymptomatic microhematuria (AMH) in low-risk patients.<br/><br/>Renate Pichler, Isabel Heidegger, Nicolai Leonhartsberger, Brigitte Stöhr, Friedrich Aigner, Jasmin Bektic, Wolfgang Horninger, Hannes Steiner (2013) <i>Anticancer research</i> <i></i> <i></i> 33: 12 5525-5530<br/>

http://publicationslist.org/jasmin.bektic/refid48 2014-01-07T10:04:19Z

Progression to castration resistance is a major problem in the treatment of advanced prostate cancer and is likely to be driven by activation of several molecular pathways, including androgen receptor (AR) and cyclic AMP-dependent protein kinase A (PKA). In this study, we examined the therapeutic efficacy of a combined inhibition of the AR and the regulatory subunit type Iα (RIα) of protein kina...<br/><br/>Iris E Eder, Martina Egger, Hannes Neuwirt, Christof Seifarth, Danilo Maddalo, Andreas Desiniotis, Georg Schäfer, Martin Puhr, Jasmin Bektic, Andrew C B Cato, Helmut Klocker (2013) <i>International journal of molecular sciences</i> <i></i> <i></i> 14: 6 11942-11962<br/>

http://publicationslist.org/jasmin.bektic/refid42 2013-01-25T20:57:46Z

Aim: We retrospectively analyzed the risk associated with undergrading Gleason score 6 (GS6) prostate cancer (PCa) at biopsy, in patients with preoperative PSA levels of 2-3,99 and 4-10 ng/ml.<br/><br/>Isabel Heidegger, Michael Ladurner, Viktor Skradski, Helmut Klocker, Georg Schäfer, Wolfgang Horninger, Jasmin Bektic (2012) <i>Anticancer Res</i> <i></i> <i></i> 32: 12 5481-5485<br/>

http://publicationslist.org/jasmin.bektic/refid43 2014-01-07T10:04:19Z

Copy number variants (CNVs) are a recently recognized class of human germ line polymorphisms and are associated with a variety of human diseases, including cancer. Because of the strong genetic influence on prostate cancer, we sought to identify functionally active CNVs associated with susceptibility of this cancer type. We queried low-frequency biallelic CNVs from 1,903 men of Caucasian origin en...<br/><br/>Francesca Demichelis, Sunita R Setlur, Samprit Banerjee, Dimple Chakravarty, Jin Yun Helen Chen, Chen X Chen, Julie Huang, Himisha Beltran, Derek A Oldridge, Naoki Kitabayashi, Birgit Stenzel, Georg Schaefer, Wolfgang Horninger, Jasmin Bektic, Arul M Chinnaiyan, Sagit Goldenberg, Javed Siddiqui, Meredith M Regan, Michale Kearney, T David Soong, David S Rickman, Olivier Elemento, John T Wei, Douglas S Scherr, Martin A Sanda, Georg Bartsch, Charles Lee, Helmut Klocker, Mark A Rubin (2012) <i>Proceedings of the National Academy of Sciences of the United States of America</i> <i></i> <i></i> 109: 17 6686-6691<br/>

http://publicationslist.org/jasmin.bektic/refid44 2013-01-25T20:57:45Z

Objectives. To evaluate prostate cancer (PCa) detection rates of real-time elastography (RTE) in dependence of tumor size, tumor volume, localization and histological type. Materials and Methods. Thirdy-nine patients with biopsy proven PCa underwent RTE before radical prostatectomy (RPE) to assess prostate tissue elasticity, and hard lesions were considered suspicious for PCa. After RPE, the prost...<br/><br/>Daniel Junker, Georg Schäfer, Friedrich Aigner, Peter Schullian, Leo Pallwein-Prettner, Jasmin Bektic, Wolfgang Horninger, Ethan J Halpern, Ferdinand Frauscher (2012) <i>ScientificWorldJournal</i> <i></i> <i></i> 2012: <br/>

http://publicationslist.org/jasmin.bektic/refid39 2011-08-21T22:14:39Z

OBJECTIVES: The objective of this study was to update an in-depth analysis of the time trend for prostate cancer (PCA) mortality in the population of Tyrol by 5 years, namely to 2008. In Tyrol, prostate-specific antigen (PSA) tests were introduced in 1988/89; more than three-quarters of all men in the age group 45-74 had at least one PSA test in the past decade. METHODS: We applied the same model...<br/><br/>Willi Oberaigner, Uwe Siebert, Wolfgang Horninger, Helmut Klocker, Jasmin Bektic, Georg Schäfer, Ferdinand Frauscher, Harald Schennach, Georg Bartsch (2011) <i>Int J Public Health</i> <i></i> <i></i> : <br/>

http://publicationslist.org/jasmin.bektic/refid41 2011-09-14T07:23:04Z

Objectives: We evaluated whether real-time 3D ultrasound (4D-US) together with clinical evaluation is an alternative to voiding cystourethrography (VCUG) after endoscopic treatment of vesicoureteral reflux (VUR) in children at postoperative follow-up. Material and Methods: We reviewed 178 children who underwent endoscopic therapy with dextranomer/hyaluronic acid copolymer in grade II or III VUR be...<br/><br/>Renate Pichler, Alexander Buttazzoni, Jasmin Bektic, Barbara Schlenck, Christian Radmayr, Peter Rehder, Josef Oswald (2011) <i>Urol Int</i> <i></i> <i></i> 87: 2 192-198<br/>

http://publicationslist.org/jasmin.bektic/refid40 2011-09-14T07:23:04Z

OBJECTIVES: To describe two predictive models that predict for prostate cancer on biopsy derived from a large screening population. There are no published predictive models that predict prostate cancer in a screened population. METHODS: The patients from the Tyrol screening study of known age, total prostate-specific antigen (PSA) level, digital rectal examination (DRE) findings, prostate volume, ...<br/><br/>Prasanna Sooriakumaran, Majnu John, Paul Christos, Jasmin Bektic, Georg Bartsch, Robert Leung, Michael Herman, Douglas Scherr, Ashutosh Tewari (2011) <i>Urology</i> <i></i> <i></i> : <br/>

http://publicationslist.org/jasmin.bektic/refid1 2011-08-21T22:14:39Z

Novel markers for prostate cancer (PCa) detection are needed. Total prostate-specific antigen (tPSA) and percent free prostate-specific antigen (%fPSA=tPSA/fPSA) lack diagnostic specificity.<br/><br/>Flip H Jansen, Ron H N van Schaik, Joep Kurstjens, Wolfgang Horninger, Helmut Klocker, Jasmin Bektic, Mark F Wildhagen, Monique J Roobol, Chris H Bangma, Georg Bartsch (2010) <i>Eur Urol</i> <i></i> <i></i> 57: 6 921-927<br/>

http://publicationslist.org/jasmin.bektic/refid38 2011-08-21T22:14:39Z

The genetic etiology of prostate cancer, the most common form of male cancer in western countries, is complex and the interplay of disease genes with environmental factors is far from being understood. Studies on somatic mitochondrial DNA (mtDNA) mutations have become an important aspect of cancer research because these mutations might have functional consequences and/or might serve as biosensors ...<br/><br/>Anita Kloss-Brandstätter, Georg Schäfer, Gertraud Erhart, Alexander Hüttenhofer, Stefan Coassin, Christof Seifarth, Monika Summerer, Jasmin Bektic, Helmut Klocker, Florian Kronenberg (2010) <i>Am J Hum Genet</i> <i></i> <i></i> 87: 6 802-812<br/>

http://publicationslist.org/jasmin.bektic/refid2 2010-10-23T16:50:02Z

It is hypothesized that ligand-independent activation of the androgen receptor is one of the mechanisms implicated in tumour progression. However, supportive evidence is limited to the effect of HER-2/neu that stimulates prostate cancer progression through activation of the androgen receptor. In the present study, we have asked whether the proinflammatory cytokine interleukin-6 (IL-6), which is kn...<br/><br/>Kamilla Malinowska, Hannes Neuwirt, Ilaria T Cavarretta, Jasmin Bektic, Hannes Steiner, Hermann Dietrich, Patrizia L Moser, Dietmar Fuchs, Alfred Hobisch, Zoran Culig (2009) <i>Endocr Relat Cancer</i> <i></i> <i></i> 16: 1 155-169<br/>

http://publicationslist.org/jasmin.bektic/refid5 2010-10-23T16:50:02Z

OBJECTIVE: To assess the pathological features of Gleason score 6 prostate cancers after radical prostatectomy in the low (<4 ng/mL) and intermediate range of prostate-specific antigen level (4-10 ng/mL), as such prostate cancers are considered to be well differentiated tumours with a low risk for recurrence after therapy. PATIENTS AND METHODS: In all, 1354 patients with T1c prostate cancer and PS...<br/><br/>Alexandre E Pelzer, Daniela Colleselli, Jasmin Bektic, Eberhard Steiner, Reinhold Ramoner, Michael Mitterberger, Christian Schwentner, Georg Schaefer, Stefano Ongarello, Georg Bartsch, Wolfgang Horninger (2008) <i>BJU Int</i> <i></i> <i></i> 101: 7 822-825<br/>

http://publicationslist.org/jasmin.bektic/refid6 2010-10-23T16:50:02Z

OBJECTIVES: To evaluate possible over- and under-diagnosis of prostate cancer in a screened vs a referral population in the same range of prostate-specific antigen (PSA). PATIENTS AND METHODS: In all, 1445 patients undergoing radical prostatectomy and with a PSA level of <10 ng/mL were evaluated; 237 were from outside Tyrol (Austria) and represented the unscreened group, and 1208 were Tyrolean scr...<br/><br/>Alexandre E Pelzer, Daniela Colleselli, Jasmin Bektic, Georg Schaefer, Stefano Ongarello, Christian Schwentner, Fritz Aigner, Michael Mitterberger, Eberhard Steiner, Georg Bartsch, Wolfgang Horninger (2008) <i>BJU Int</i> <i></i> <i></i> 101: 10 1223-1226<br/>

http://publicationslist.org/jasmin.bektic/refid7 2010-10-23T16:50:02Z

PURPOSE: We sought to evaluate the efficacy of transdermal dihydrotestosterone treatment based on the results of hypospadias repair in children with primary hypospadias. MATERIALS AND METHODS: A total of 75 randomized consecutive children who were a mean of 33.4 +/- 3.7 months old and had primary hypospadias were included in the study between September 2004 and April 2006. While 37 children were t...<br/><br/>Cevdet Kaya, J Bektic, C Radmayr, C Schwentner, G Bartsch, J Oswald (2008) <i>J Urol</i> <i></i> <i></i> 179: 2 684-688<br/>

http://publicationslist.org/jasmin.bektic/refid4 2010-10-23T16:50:02Z

OBJECTIVE: To evaluate the effectiveness of a well-controlled programme of early detection and treatment of prostate cancer in the population of Tyrol, Austria, where such a programme of early detection and treatment was initiated in 1988 and where prostate-specific antigen (PSA) testing was offered for free to all men aged 45-75 years from 1993. SUBJECTS AND METHODS: Comparison of prostate cancer...<br/><br/>Georg Bartsch, Wolfgang Horninger, Helmut Klocker, Alexandre Pelzer, Jasmin Bektic, Wilhelm Oberaigner, Harald Schennach, Georg Schäfer, Ferdinand Frauscher, Mathieu Boniol, Gianluca Severi, Chris Robertson, Peter Boyle (2008) <i>BJU Int</i> <i></i> <i></i> 101: 7 809-816<br/>

http://publicationslist.org/jasmin.bektic/refid3 2010-10-23T16:50:02Z

OBJECTIVE: To evaluate the clinical and pathological characteristics of screen vs non-screen-detected prostate cancers, to determine if there is a difference in the same prostate-specific antigen (PSA) range. PATIENTS AND METHODS: In all, 997 patients who had had a radical prostatectomy were evaluated; 806 were Tyrolean screening volunteers, and 191 were from outside Tyrol, representing the 'refer...<br/><br/>Alexandre E Pelzer, Daniela Colleselli, Jasmin Bektic, Georg Schaefer, Stefano Ongarello, Christian Schwentner, Leo Pallwein, Michael Mitterberger, Eberhard Steiner, Georg Bartsch, Wolfgang Horninger (2008) <i>BJU Int</i> <i></i> <i></i> 102: 1 24-27<br/>

http://publicationslist.org/jasmin.bektic/refid11 2010-10-23T16:50:02Z

OBJECTIVE: To describe the influence of blood sampling/sampling tubes on mass spectrometric and clustering results, and on clinical blood variables, in blood samples collected from healthy volunteers and patients with prostate cancer. PATIENTS, SUBJECTS AND METHODS: Two venous blood samples were taken from 12 healthy volunteers and 12 patients with localized prostate cancer. Two blood samples were...<br/><br/>Alexandre E Pelzer, Isabel Feuerstein, Christian Fuchsberger, Stefano Ongarello, Jasmin Bektic, Christian Schwentner, Helmut Klocker, George Bartsch, Guenther K Bonn (2007) <i>BJU Int</i> <i></i> <i></i> 99: 3 658-662<br/>

http://publicationslist.org/jasmin.bektic/refid12 2010-10-23T16:50:02Z

OBJECTIVES: To assess the longitudinal prostate-specific antigen (PSA) changes in a screening population with or without prostate cancer during a 10-year period. METHODS: Serial PSA measurements performed during a 10-year period were evaluated in 4272 participants of a screening program who had no evidence of prostate malignancy and 528 men who eventually developed prostate cancer. RESULTS: Of the...<br/><br/>Andreas P Berger, Martina Deibl, Alexander Strasak, Jasmin Bektic, Alexandre E Pelzer, Helmut Klocker, Hannes Steiner, Gernot Fritsche, Georg Bartsch, Wolfgang Horninger (2007) <i>Urology</i> <i></i> <i></i> 69: 1 134-138<br/>

http://publicationslist.org/jasmin.bektic/refid10 2010-10-23T16:50:02Z

Highly active antiretroviral therapy including HIV protease inhibitors has led to a marked reduction of clinically relevant mucosal candidiasis. We have previously shown that HIV protease inhibitors directly inhibit adhesion of Candida albicans to epithelial cells at concentrations that are reached in vivo during antiretroviral therapy. The aim of this study was to establish whether HIV protease i...<br/><br/>Barbara Falkensammer, Georg Pilz, Jasmin Bektić, Pankorn Imwidthaya, Karin Jöhrer, Cornelia Speth, Cornelia Lass-Flörl, Manfred P Dierich, Reinhard Würzner (2007) <i>Mycoses</i> <i></i> <i></i> 50: 3 172-177<br/>

http://publicationslist.org/jasmin.bektic/refid9 2010-10-23T16:50:02Z

PURPOSE: Since the implementation of widespread serum total prostate specific antigen based screening, the risk of prostate cancer over diagnosis has become a concern. We evaluated the amount of possible over and under diagnosis of prostate cancer in an asymptomatic screening population with a total prostate specific antigen of 2.0 to 3.9 (lower range) and 4.0 to 10.0 ng/ml (higher range). MATERIA...<br/><br/>Alexandre E Pelzer, Jasmin Bektic, Thomas Akkad, Stefano Ongarello, Georg Schaefer, Christian Schwentner, Ferdinand Frauscher, Georg Bartsch, Wolfgang Horninger (2007) <i>J Urol</i> <i></i> <i></i> 178: 1 93-7; discussion 97<br/>

http://publicationslist.org/jasmin.bektic/refid8 2010-10-23T16:50:02Z

OBJECTIVE: To evaluate the influence of prostate volume (PV) on the detection of prostate cancer using a combined approach of contrast-enhanced ultrasonography (CEUS) and grey-scale US-guided systematic biopsy (SB). PATIENTS AND METHODS: We evaluated 345 patients with prostate cancer and a total prostate-specific antigen (PSA) level of >/= 1.32 ng/mL (1.32-35.3, mean 6.6). Biopsies were taken by t...<br/><br/>Daniela Colleselli, Jasmin Bektic, Georg Schaefer, Ferdinand Frauscher, Michael Mitterberger, Andrea Brunner, Christian Schwentner, Georg Bartsch, Wolfgang Horninger, Alexandre E Pelzer (2007) <i>BJU Int</i> <i></i> <i></i> 100: 6 1264-1267<br/>

http://publicationslist.org/jasmin.bektic/refid16 2010-10-23T16:50:02Z

The aim of this study was to identify amplified oncogenes in endometrial cancer using array-based comparative genomic hybridization (array CGH). Despite its prevalence, the molecular mechanisms of endometrial carcinogenesis are still poorly understood. The selected array CGH allows the simultaneous examination of 58 oncogenes commonly amplified in human cancers and is capable of achieving increase...<br/><br/>S A O'Toole, E Dunn, B L Sheppard, H Klocker, J Bektic, P Smyth, C Martin, O Sheils, J J O'Leary (2006) <i>Int J Gynecol Cancer</i> <i></i> <i></i> 16: 2 834-842<br/>

http://publicationslist.org/jasmin.bektic/refid17 2010-10-23T16:50:02Z

PURPOSE: ATF3 is a member of the basic leucine zipper/cyclic adenosine monophosphate responsive element binding protein family of transcription factors. There is overwhelming evidence that it is a stress inducible factor acting in a signal-type and cell-type dependent manner, and it is involved in cell proliferation and survival. We found that ATF3 was differently expressed in an in vitro prostate...<br/><br/>Alexandre E Pelzer, Jasmin Bektic, Petra Haag, Andreas P Berger, Armin Pycha, Georg Schäfer, Hermann Rogatsch, Wolfgang Horninger, Georg Bartsch, Helmut Klocker (2006) <i>J Urol</i> <i></i> <i></i> 175: 4 1517-1522<br/>

http://publicationslist.org/jasmin.bektic/refid15 2010-10-23T16:50:02Z

OBJECTIVE: To evaluate prostatic vascular resistance by measuring the resistive index (RI), and flow velocity using colour Doppler ultrasonography (CDUS), in normal prostates and in patients with benign prostatic hyperplasia (BPH) or prostate cancer, as BPH is considered to be a result of urogenital ageing and studies suggest that hyperplasia in the stromal and glandular compartments might be indu...<br/><br/>Andreas P Berger, Wolfgang Horninger, Jasmin Bektic, Alexandre Pelzer, Robert Spranger, George Bartsch, Ferdinand Frauscher (2006) <i>BJU Int</i> <i></i> <i></i> 98: 3 587-590<br/>

http://publicationslist.org/jasmin.bektic/refid37 2010-10-23T17:06:44Z

Jasmin Bektic, Roman Guggenberger, Barbara Spengler, Volker Christoffel, Alexandre Pelzer, Andreas P. Berger, Reinhold Ramoner, Georg Bartsch and Helmut Klocker. (2006) <i>Maturitas</i> 55: S37-S47<br/>

http://publicationslist.org/jasmin.bektic/refid14 2010-10-23T16:50:02Z

BACKGROUND: Interleukin-6 (IL-6) is a multifunctional regulator of cellular events in prostate cancer. LNCaP-IL-6+ cells selected in the presence of IL-6 were taken for assessment of effects of the chimeric monoclonal anti-IL-6 antibody CNTO 328. METHODS: Cell viability was assessed after treatment with CNTO 328 by the ATP assay. Expression of Bcl-2 and Bax and activation of signaling pathways wer...<br/><br/>Hannes Steiner, Ilaria T Cavarretta, Patrizia L Moser, Andreas P Berger, Jasmin Bektic, Hermann Dietrich, Mohamed H Zaki, Marian Nakada, Alfred Hobisch, Jeffrey A Nemeth, Zoran Culig (2006) <i>Prostate</i> <i></i> <i></i> 66: 16 1744-1752<br/>

http://publicationslist.org/jasmin.bektic/refid13 2010-10-23T16:50:02Z

OBJECTIVES: To evaluate, in a screening population, the impact of tumor volume and prostate volume on prostate-specific antigen (PSA) velocity (PSAV) and to find predictors of biochemical failure after radical prostatectomy. Longitudinal PSA changes in men with prostate cancer have been reported to be significantly different from those without prostate cancer. METHODS: PSAV was assessed in 102 men...<br/><br/>Andreas P Berger, Martina Deibl, Alexander Strasak, Jasmin Bektic, Alexandre Pelzer, Hannes Steiner, Robert Spranger, Gernot Fritsche, Georg Bartsch, Wolfgang Horninger (2006) <i>Urology</i> <i></i> <i></i> 68: 5 1067-1071<br/>

http://publicationslist.org/jasmin.bektic/refid18 2010-10-23T16:50:02Z

OBJECTIVES: To investigate the prostate cancer (PCa) detection rates and Gleason scores in patients with serum prostate-specific antigen (PSA) levels of 2.0 to 3.9 ng/mL and 4.0 to 10 ng/mL (free PSA 18% or less), in a population-based screening project. With the use of prostate-specific antigen (PSA) screening, more PCa is being diagnosed at PSA values of less than 4 ng/mL. METHODS: A total of 34...<br/><br/>Alexandre E Pelzer, Ashutosh Tewari, Jasmin Bektic, Andreas P Berger, Ferdinand Frauscher, Georg Bartsch, Wolfgang Horninger (2005) <i>Urology</i> <i></i> <i></i> 66: 5 1029-1033<br/>

http://publicationslist.org/jasmin.bektic/refid23 2010-10-23T16:50:02Z

We investigated the effects of androgen receptor (AR) down regulation with a small interference RNA molecule (siRNA_AR(start)) on androgen sensitive LNCaP and androgen independent LNCaPabl prostate cancer cells, the latter representing an in vitro model for the development of therapy resistance in prostate cancer. Although LNCaPabl cells express increased levels of AR in comparison with androgen s...<br/><br/>Petra Hååg, Jasmin Bektic, Georg Bartsch, Helmut Klocker, Iris E Eder (2005) <i>J Steroid Biochem Mol Biol</i> <i></i> <i></i> 96: 3-4 251-258<br/>

http://publicationslist.org/jasmin.bektic/refid26 2010-10-23T16:50:02Z

AIMS/HYPOTHESIS: The aim of this study was to evaluate the relationship between benign prostatic hyperplasia (BPH) and arteriosclerosis shown in a model of type 2 diabetes in a trans-sectional population study using contrast-enhanced colour Doppler ultrasound for exact assessment of prostatic blood flow. METHODS: Contrast-enhanced transrectal colour Doppler ultrasound was performed using a microbu...<br/><br/>A P Berger, M Deibl, E J Halpern, M Lechleitner, J Bektic, W Horninger, G Fritsche, H Steiner, A Pelzer, G Bartsch, F Frauscher (2005) <i>Diabetologia</i> <i></i> <i></i> 48: 4 784-789<br/>

http://publicationslist.org/jasmin.bektic/refid27 2010-10-23T16:50:02Z

BACKGROUND: RhoE/Rnd3, a recently described novel member of the Rho GTPases family, was discussed as a possible antagonist of the RhoA protein that stimulates cell cycle progression and is overexpressed and/or overactivated in prostate cancer. We investigated the expression of RhoE and its role in cell cycle regulation and apoptosis in the human prostate. METHODS: RhoE expression in cell lines and...<br/><br/>Jasmin Bektic, Karina Pfeil, Andreas Paul Berger, Reinhold Ramoner, Alexandre Pelzer, Georg Schäfer, Kurt Kofler, Georg Bartsch, Helmut Klocker (2005) <i>Prostate</i> <i></i> <i></i> 64: 4 332-340<br/>

http://publicationslist.org/jasmin.bektic/refid28 2010-10-23T16:50:02Z

BACKGROUND: To determine longitudinal PSA changes over a period of 10 years in patients with and without prostate cancer. METHODS: Serial PSA measurements performed over 10 years were evaluated in 353 men who eventually developed prostate cancer and in 2.462 participants of a screening program without prostatic malignancy. RESULTS: In men with cancer, mean tPSA increased from 2.28 ng/ml at 10 year...<br/><br/>Andreas P Berger, Martina Deibl, Hannes Steiner, Jasmin Bektic, Alexandre Pelzer, Robert Spranger, Helmut Klocker, Georg Bartsch, Wolfgang Horninger (2005) <i>Prostate</i> <i></i> <i></i> 64: 3 240-245<br/>

http://publicationslist.org/jasmin.bektic/refid25 2010-10-23T16:50:02Z

Prostatic carcinoma is the most frequent malignant disease in men and associated with very high mortality. The diagnostic work-up of prostatic carcinoma is based on tests to determine the level of prostate-specific antigen (PSA), digital rectal examination, and transrectal sonography. Due to diagnostic limitations, ultrasound-guided prostate biopsy is the method of choice for diagnosis of prostati...<br/><br/>F Frauscher, L Pallwein, A Klauser, A P Berger, F Koppelstaetter, J Gradl, M Schurich, J Bektic, G M Pinggera, E J Halpern, W Horninger, G Bartsch, D zur Nedden (2005) <i>Radiologe</i> <i></i> <i></i> 45: 6 544-551<br/>

http://publicationslist.org/jasmin.bektic/refid24 2010-10-23T16:50:02Z

PURPOSE: Transrectal gray scale ultrasound guided biopsy is the standard method for diagnosing prostate cancer (PC). Improved cancer detection with ultrasound contrast agents is related to better detection of tumor vascularity. We evaluated the impact of a combined approach of contrast enhanced, color Doppler targeted biopsy (CECD) and systematic biopsy (SB) for the PC detection rate in men with p...<br/><br/>Alexandre Pelzer, Jasmin Bektic, Andreas P Berger, Leo Pallwein, Ethan J Halpern, Wolfgang Horninger, Georg Bartsch, Ferdinand Frauscher (2005) <i>J Urol</i> <i></i> <i></i> 173: 6 1926-1929<br/>

http://publicationslist.org/jasmin.bektic/refid20 2010-10-23T16:50:02Z

OBJECTIVE: To evaluate the prostate cancer detection rate at low total prostate-specific antigen (tPSA) ranges of 2.6-4 and 4.1-10 ng/mL, according to different percentage free (f/t) PSA levels in a screening population. SUBJECTS AND METHODS: In all, 1809 consecutive screening volunteers with a tPSA level of 2.6-10.0 ng/mL were assessed. Ten systematic ultrasonography-guided prostate biopsies and,...<br/><br/>Alexandre E Pelzer, Hubert Volgger, Jasmin Bektic, Andreas P Berger, Peter Rehder, Georg Bartsch, Wolfgang Horninger (2005) <i>BJU Int</i> <i></i> <i></i> 96: 7 995-998<br/>

http://publicationslist.org/jasmin.bektic/refid21 2010-10-23T16:50:02Z

Differences in diet have been proposed to be at least partially responsible for the low rate of prostate cancer in Asian populations compared with men in Western countries. One of the compounds that occurs in a greater quantity in the Eastern diet is genistein, an isoflavonoid found in high concentrations in serum after ingestion of soy-rich foods. Extensive molecular studies have been performed t...<br/><br/>Jasmin Bektic, Roman Guggenberger, Iris E Eder, Alexandre E Pelzer, Andreas P Berger, Georg Bartsch, Helmut Klocker (2005) <i>Clin Prostate Cancer</i> <i></i> <i></i> 4: 2 124-129<br/>

http://publicationslist.org/jasmin.bektic/refid22 2010-10-23T16:50:02Z

OBJECTIVES: The present retrospective study was designed to investigate the value of transition zone (TZ) biopsies for prostate cancer (PC) detection rate in a combined contrast enhanced color Doppler targeted (CECD) and gray-scale systematic biopsy (SB) approach. METHODS: PSA screening participants totalling 1475 with tPSA of >1.25 ng/ml (fPSA< or =18%) were assessed. Ten SB and additionally 5 or...<br/><br/>Alexandre E Pelzer, Jasmin Bektic, Andreas P Berger, Ethan J Halpern, Florian Koppelstätter, Andrea Klauser, Peter Rehder, Wolfgang Horninger, Georg Bartsch, Ferdinand Frauscher (2005) <i>Eur Urol</i> <i></i> <i></i> 48: 6 916-21; discussion 921<br/>

http://publicationslist.org/jasmin.bektic/refid19 2010-10-23T16:50:02Z

OBJECTIVE: To assess benign prostatic hyperplasia (BPH) and erectile dysfunction (ED), both considered to be associated with urogenital ageing, in ageing men in a cross-sectional population study, comparing them with healthy controls by using symptom scores and contrast-enhanced colour Doppler ultrasonography (CDUS). PATIENTS, SUBJECTS AND METHODS: Transrectal CDUS and quantitative measurement of ...<br/><br/>Andreas P Berger, Martina Deibl, Nicolai Leonhartsberger, Jasmin Bektic, Wolfgang Horninger, Gernot Fritsche, Hannes Steiner, Alexandre E Pelzer, Georg Bartsch, Ferdinand Frauscher (2005) <i>BJU Int</i> <i></i> <i></i> 96: 7 1073-1078<br/>

http://publicationslist.org/jasmin.bektic/refid32 2010-10-23T16:50:02Z

Estrogens have profound effects on the developing prostate and are suspected to contribute to the development of benign prostatic hyperplasia, but the mechanism by which this hormone elicits its regulatory function still remains largely unknown. Using complementary RNA microarrays comprising approximately 10,000 oligonucleotide gene targets we compared differences in mRNA expression of estradiol-t...<br/><br/>Jasmin Bektic, Oliver A Wrulich, Gabriele Dobler, Kurt Kofler, Florian Ueberall, Zoran Culig, Georg Bartsch, Helmut Klocker (2004) <i>Genomics</i> <i></i> <i></i> 83: 1 34-44<br/>

http://publicationslist.org/jasmin.bektic/refid29 2010-10-23T16:50:02Z

PURPOSE: Phytoestrogens are nonsteroidal plant derived compounds with estrogenic activity that have been implicated in protecting against prostate cancer progression. We hypothesized that these compounds would alter cell number and increase the ability of antiandrogens to induce cell death in prostate cancer cells. MATERIALS AND METHODS: RWPE-1, LNCaP and PC-3 cells were treated with or without an...<br/><br/>Colm Morrissey, Jasmin Bektic, Barbara Spengler, David Galvin, Volker Christoffel, Helmut Klocker, John M Fitzpatrick, R William G Watson (2004) <i>J Urol</i> <i></i> <i></i> 172: 6 Pt 1 2426-2433<br/>

http://publicationslist.org/jasmin.bektic/refid31 2010-10-23T16:50:02Z

OBJECTIVES: Isoflavonoids are discussed for use in chemoprevention and treatment of prostate cancer. We investigated the potential of genistein to modulate androgen receptor (AR) expression and transcriptional activity in the human androgen-sensitive prostate cancer cell line LNCaP. MATERIALS AND METHODS: AR expression at mRNA and protein level was analyzed by real-time RT-PCR and immunoblot, resp...<br/><br/>Jasmin Bektic, Andreas P Berger, Karina Pfeil, Gabriele Dobler, Georg Bartsch, Helmut Klocker (2004) <i>Eur Urol</i> <i></i> <i></i> 45: 2 245-51; discussion 251<br/>

http://publicationslist.org/jasmin.bektic/refid33 2010-10-23T16:50:02Z

PURPOSE: Transurethral resection of the prostate (TURP) is still the gold standard for the surgical treatment of symptomatic benign prostatic hyperplasia. However, the associated morbidity and blood loss remain concerns. A coagulating intermittent cutting (CIC) device with constant voltage pulses and controlled pulse intervals was recently developed. The impact of CIC on bleeding and blood transfu...<br/><br/>Andreas P Berger, Walter Wirtenberger, Jasmin Bektic, Hannes Steiner, Robert Spranger, Georg Bartsch, Wolfgang Horninger (2004) <i>J Urol</i> <i></i> <i></i> 171: 1 289-291<br/>

http://publicationslist.org/jasmin.bektic/refid30 2010-10-23T16:50:02Z

Because of the heterogeneity of prostate cancer knowledge about the genes involved in prostate carcinogenesis is still very limited. Previously, the use of novel high-throughput technologies offered the possibility to investigate broad gene expression profiles and thus helped to improve understanding of the molecular basis of prostate disease. Many candidate genes have been identified so far which...<br/><br/>I E Eder, J Bektic, P Haag, G Bartsch, H Klocker (2004) <i>BJU Int</i> <i></i> <i></i> 93: 8 1151-1155<br/>

http://publicationslist.org/jasmin.bektic/refid35 2010-10-23T16:50:02Z

BACKGROUND: Local hypoxia may be one of the triggers of embryonic reawakening of the stroma and subsequent hyperplastic growth in the prostate. Using a cell culture model of human prostatic stromal cells, we investigated the effects of hypoxia on activation of hypoxia-inducible factor 1 (HIF 1) and on the production of growth factors. METHODS: Primary prostatic stromal cells were grown in normal a...<br/><br/>Andreas P Berger, Kurt Kofler, Jasmin Bektic, Hermann Rogatsch, Hannes Steiner, Georg Bartsch, Helmut Klocker (2003) <i>Prostate</i> <i></i> <i></i> 57: 1 57-65<br/>

http://publicationslist.org/jasmin.bektic/refid34 2010-10-23T16:50:02Z

We have shown recently that inhibition of androgen receptor (AR) expression with an antisense AR oligonucleotide (ODN) inhibits LNCaP prostate tumor cells in vitro as well as in vivo. In this study, we investigated gene expression changes that occur after AR signaling blockade, either through AR elimination by antisense treatment or through complete androgen receptor inhibition by androgen depriva...<br/><br/>Iris E Eder, Petra Haag, Mark Basik, Spyro Mousses, Jasmin Bektic, Georg Bartsch, Helmut Klocker (2003) <i>Mol Carcinog</i> <i></i> <i></i> 37: 4 181-191<br/>

http://publicationslist.org/jasmin.bektic/refid36 2010-10-23T16:50:02Z

Oropharyngeal candidiasis is one of the first and most commonly reported opportunistic infections of untreated AIDS patients. With the introduction of the new antiviral HAART therapy, including HIV protease inhibitors, this mucocutaneous infection is nowadays only rarely observed in treated patients. It was recently shown that HIV protease inhibitors have a direct attenuating effect on Candida alb...<br/><br/>J Bektić, C P Lell, A Fuchs, H Stoiber, C Speth, C Lass-Flörl, M Borg-von Zepelin, M P Dierich, R Würzner (2001) <i>FEMS Immunol Med Microbiol</i> <i></i> <i></i> 31: 1 65-71<br/>