Javier Santos's Publications List

A closer look at mucosal inflammation in irritable bowel syndrome: sex- and gender-related disparities--quantity, quality, or both?

2009-05-01T00:27:31Z

Irritable bowel syndrome remains a bothersome and frustrating disorder that imposes a heavy and growing socio-economic toll on its sufferers, two-thirds of whom are women, and on health care systems. The biomedical community must take a giant step forward into the discipline of women's gastrointestinal health. Efforts and accomplishments, such as the one reported in this month's issue by Cremon et...

Carmen Alonso, Javier Santos (2009) Am J Gastroenterol 104: 2 401-403

Impaired intestinal molecular tightness in the mucosa of irritable bowel syndrome: what are the mediators?

2009-05-01T00:25:55Z

Maria Vicario, Carmen Alonso, Javier Santos (2009) Gut 58: 2 161-162

Unstable composition of the fecal microbiota in ulcerative colitis during clinical remission.

2009-05-01T00:28:54Z

BACKGROUND AND AIM: Studies have identified abnormal characteristics of the gut microbiota in patients with active IBD, but whether the changes are causal or secondary to inflammation remains uncertain. We investigated dynamics of fecal microbiota in ulcerative colitis (UC) during remission by genomic technology. PATIENTS AND METHODS: Patients in clinical remission and on stable maintenance mesala...

Cristina Martinez, Maria Antolin, Javier Santos, Antonio Torrejon, Francesc Casellas, Natalia Borruel, Francisco Guarner, Juan-R Malagelada (2008) Am J Gastroenterol 103: 3 643-648

Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation.

2009-05-01T00:25:55Z

BACKGROUND & AIMS: Irritable bowel syndrome (IBS), a highly prevalent disorder among women, has been associated with life stress, but the peripheral mechanisms involved remain largely unexplored. METHODS: A 20-cm jejunal segment perfusion was performed in 2 groups of young healthy women, equilibrated by menstrual phase, experiencing either low (LS; n = 13) or moderate background stress (MS; n = 11...

Carmen Alonso, Mar Guilarte, Maria Vicario, Laura Ramos, Ziad Ramadan, Maria Antolín, Cristina Martínez, Serge Rezzi, Esteban Saperas, Sunil Kochhar, Javier Santos, Juan Ramón Malagelada (2008) Gastroenterology 135: 1 163-172.e1

Stress neuropeptides evoke epithelial responses via mast cell activation in the rat colon.

2009-05-01T00:25:55Z

BACKGROUND: Previously, we showed that corticotropin-releasing factor (CRF) injected i.p. mimicked epithelial responses to stress, both stimulating ion secretion and enhancing permeability in the rat colon, and mast cells were involved. However, the ability of CRF-sensitive mucosal/submucosal loops to regulate intestinal barrier and the participation of resident mast cells are unclear. METHODS: We...

Javier Santos, Derrick Yates, Mar Guilarte, Maria Vicario, Carmen Alonso, Mary H Perdue (2008) Psychoneuroendocrinology 33: 9 1248-1256

Neuropharmacology of stress-induced mucosal inflammation: implications for inflammatory bowel disease and irritable bowel syndrome.

2009-05-01T00:25:55Z

Inflammatory bowel disease (IBD) and the irritable bowel syndrome (IBS) are common causes of medical consultation and the most frequent diagnosis raised by gastroenterologists. Recent years have witnessed considerable advances in the understanding of the mechanisms involved in the initiation and perpetuation of these chronic and recurrent disorders. However, particularly in IBS, the success of the...

Javier Santos, Carmen Alonso, María Vicario, Laura Ramos, Beatriz Lobo, J-Ramón Malagelada (2008) Curr Mol Med 8: 4 258-273

Stress-mast cell axis and regulation of gut mucosal inflammation: from intestinal health to an irritable bowel

2009-05-01T00:25:55Z

The functional gastrointestinal disorders and the irritable bowel syndrome, in particular, represent one of the commonest causes of medical consultation and the most frequent diagnosis raised by the gastroenterologists. Despite their high prevalence, the aetiology and pathophysiology of these functional digestive disorders remains unclear and specific diagnostic markers and clearly effective thera...

Laura Ramos, María Vicario, Javier Santos (2007) Med Clin (Barc) 129: 2 61-69

Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum.

2009-05-01T00:25:55Z

BACKGROUND: Increased numbers of mast cells and mast cell activation in distal gut segments are associated with symptom onset and severity in irritable bowel syndrome (IBS). Although upper gut symptoms are common, mast cells have not been thoroughly evaluated in proximal gut in IBS patients. METHODS: Jejunal biopsies obtained by Watson's capsule, aspiration of intestinal fluid and one blood sample...

Mar Guilarte, Javier Santos, Inés de Torres, Carmen Alonso, María Vicario, Laura Ramos, Cristina Martínez, Francesc Casellas, Esteban Saperas, Juan Ramón Malagelada (2007) Gut 56: 2 203-209

Targeting mast cells in the treatment of functional gastrointestinal disorders.

2009-05-01T00:25:55Z

Enhanced knowledge of the pathophysiological basis of functional gastrointestinal disorders indicates that low-grade mucosal inflammation and mast cell hyperplasia are common findings. Mast cells are multipotent and mucosa-dwelling residents are uniquely located to communicate with host immune and nervous supersystems and with the gut microflora to provide tight microenvironmental conditions. Main...

Javier Santos, Carmen Alonso, Mar Guilarte, María Vicario, Juan Ramón Malagelada (2006) Curr Opin Pharmacol 6: 6 541-546

Prevalence of functional gastrointestinal disorders in women who report domestic violence to the police.

2009-05-01T00:30:05Z

BACKGROUND & AIMS: Retrospective studies found an association between past sexual, physical, or psychological abuse and functional gastrointestinal disorders (FGIDs). However, there are no studies evaluating such an association concurrently with the ongoing abuse. Our aim was to investigate the prevalence of the main FGIDs, functional dyspepsia and irritable bowel syndrome, in 70 women reporting a...

Mónica Perona, Ruth Benasayag, Antonia Perelló, Javier Santos, Natalia Zárate, Patricia Zárate, Fermín Mearin (2005) Clin Gastroenterol Hepatol 3: 5 436-441

Anisakis simplex-induced small bowel obstruction after fish ingestion: preliminary evidence for response to parenteral corticosteroids.

2009-05-01T00:27:31Z

BACKGROUND & AIMS: Gastrointestinal anisakiasis, a fish-borne zoonoses, may be acquired by humans after the ingestion of raw marine fish infested with larvae of the nematode Anisakis simplex. Because of the invasive nature of the parasite, inflammatory obstruction or perforation of the gut wall may result. Although rare, Anisakis-induced intestinal obstruction is becoming a growing public health p...

Laura Ramos, Carmen Alonso, Mar Guilarte, Jaime Vilaseca, Javier Santos, Juan Ramon Malagelada (2005) Clin Gastroenterol Hepatol 3: 7 667-671

Pathogenesis of irritable bowel syndrome: the mast cell connection.

2009-05-01T00:27:31Z

Javier Santos, Mar Guilarte, Carmen Alonso, J R Malagelada (2005) Scand J Gastroenterol 40: 2 129-140

Eosinophilic enteritis as cause of acute abdomen

2009-05-01T00:32:10Z

J Santos Vicente, J Vilaseca Momplet (2003) An Med Interna 20: 1

Physical and psychological stress in rats enhances colonic epithelial permeability via peripheral CRH.

2009-05-01T00:33:12Z

Stress may be a contributing factor in intestinal inflammatory disease; however, the underlying mechanisms have not been elucidated. We previously reported that acute stress altered jejunal epithelial physiology. In this study, we examined both physical and psychological stress-induced functional changes in colonic mucosa. Colonic mucosal tissue from rats subjected to either 2 hr of cold-restraint...

Paul R Saunders, Javier Santos, Nico P M Hanssen, Derrick Yates, Jack A Groot, Mary H Perdue (2002) Dig Dis Sci 47: 1 208-215

Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat.

2009-05-01T00:33:12Z

BACKGROUND AND AIMS: Stress may be an important factor in exacerbating inflammatory bowel disease but the underlying mechanism is unclear. Defective epithelial barrier function may allow uptake of luminal antigens that stimulate an immune/inflammatory response. Here, we examined the effect of chronic stress on colonic permeability and the participation of mast cells in this response. METHODS: Mast...

J Santos, P C Yang, J D Söderholm, M Benjamin, M H Perdue (2001) Gut 48: 5 630-636

Adaptation of stress-induced mucosal pathophysiology in rat colon involves opioid pathways.

2009-05-01T00:33:12Z

Acute stress increases ion secretion and permeability of rat colonic epithelium. However, it is not known if stress-induced mucosal changes are subject to adaptation. Wistar-Kyoto rats were exposed to either continuous water-avoidance stress (CS) for 60 min or intermittent stress (IS) for three 20-min periods. Distal colonic segments were mounted in Ussing Chambers, and ion-transport [short-circui...

D A Yates, J Santos, J D Söderholm, M H Perdue (2001) Am J Physiol Gastrointest Liver Physiol 281: 1 G124-G128

Chronic stress impairs rat growth and jejunal epithelial barrier function: role of mast cells.

2009-05-01T00:33:12Z

We examined the impact of chronic stress on rat growth rate and intestinal epithelial physiology and the role of mast cells in these responses. Mast cell-deficient (Ws/Ws) rats and +/+ littermate controls were submitted to water avoidance stress or sham stress, 1 h/day, for 5 days. Seven hours after the last sham or stress session, jejunal segments were mounted in Ussing chambers, in which secreti...

J Santos, M Benjamin, P C Yang, T Prior, M H Perdue (2000) Am J Physiol Gastrointest Liver Physiol 278: 6 G847-G854

Stress and neuroimmune regulation of gut mucosal function.

2009-05-01T00:33:12Z

J Santos, M H Perdue (2000) Gut 47 Suppl 4: iv49-51; discussion iv52

Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat.

2009-05-01T00:33:12Z

We examined the effect of stress on colonic epithelial physiology, the role of corticotropin-releasing hormone (CRH), and the pathways involved. Rats were restrained or injected intraperitoneally with CRH or saline. Colonic segments were mounted in Ussing chambers, in which ion secretion and permeability (conductance and probe fluxes) were measured. To test the pathways involved in CRH-induced cha...

J Santos, P R Saunders, N P Hanssen, P C Yang, D Yates, J A Groot, M H Perdue (1999) Am J Physiol 277: 2 Pt 1 G391-G399

Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy.

2009-05-01T00:28:54Z

BACKGROUND: Food allergy is a common complaint among patients with a broad spectrum of abdominal and extra-abdominal symptoms that must be distinguished from other more common non-immunological food intolerances. AIMS: To investigate whether human intestinal hypersensitivity reactions are associated with detectable release of inflammatory mediators from activated cells, which may serve as a biolog...

J Santos, C Bayarri, E Saperas, C Nogueiras, M Antolín, M Mourelle, A Cadahia, J R Malagelada (1999) Gut 45: 4 553-558

Alimentary allergies

2009-05-01T00:32:10Z

J Santos Vicente (1998) Gastroenterol Hepatol 21: 7 361-369

Release of mast cell mediators into the jejunum by cold pain stress in humans.

2009-05-01T00:28:54Z

BACKGROUND & AIMS: The central nervous system regulates gut functions via complex interactions between the enteric nervous and immune systems. The aim of this study was to investigate whether mast cell mediators are released into the human jejunal lumen during stress. METHODS: A closed-segment perfusion technique was used to investigate jejunal release of tryptase, histamine, prostaglandin D2, and...

J Santos, E Saperas, C Nogueiras, M Mourelle, M Antolín, A Cadahia, J R Malagelada (1998) Gastroenterology 114: 4 640-648

Immunological regulation of intestinal epithelial transport.

2009-05-01T00:33:12Z

J Santos, M H Perdue (1998) Digestion 59: 4 404-408

Food allergy and its role in gastrointestinal diseases

2009-05-01T00:32:10Z

Food antigens may play an important role in the etiology of a variety of gastrointestinal conditions ranging from food allergy and malabsorption syndromes to inflammatory bowel disease. However, the prevailing terminological confusion relative to allergy in the last years and in particular on the definition and classification of adverse reactions to foods joined to the absence of definitive diagno...

J Santos Vicente (1997) Rev Esp Enferm Dig 89: 7 551-558

Regulation of intestinal mast cells and luminal protein release by cerebral thyrotropin-releasing hormone in rats.

2009-05-01T00:28:54Z

BACKGROUND & AIMS: Intestinal mast cell activity is modulated by the central nervous system, but the mechanisms are not well established. The aim of this study was to investigate whether cerebral thyrotropin-releasing hormone (TRH) activates intestinal mast cells and to elucidate the mechanisms involved, specifically, the contribution of mast cells to vagally stimulated luminal protein release. ME...

J Santos, E Saperas, M Mourelle, M Antolín, J R Malagelada (1996) Gastroenterology 111: 6 1465-1473

Ehlers-Danlos syndrome with giant duodenal diverticulum as a cause of cholangitis

2009-05-01T00:32:10Z

The case of a patient with the Ehlers-Danlos syndrome who presented a picture of acute cholangitis only attributable to the presence of a large duodenal diverticulum is reported. The pathologic implications of the duodenal diverticula are described with special attention being given to their participation in the development of acute cholangitis. The digestive manifestations associated to the Ehler...

F Junquera Flórez, J Santos Vicente, J Molero Richard, J Vilaseca Momplet (1995) Gastroenterol Hepatol 18: 2 84-86

Central vagal activation by an analogue of TRH stimulates gastric nitric oxide release in rats.

2009-05-01T00:30:59Z

In the stomach nitric oxide (NO) appears to be involved in vagally induced cholinergic vasodilation and nonadrenergic, noncholinergic relaxation of the fundus. We investigated whether central vagal activation by intracisternal injection of a thyrotropin-releasing hormone (TRH) analogue stimulates gastric NO release in anesthetized rats. To quantitate gastric NO production, the luminal release of N...

E Saperas, M Mourelle, J Santos, S Moncada, J R Malagelada (1995) Am J Physiol 268: 6 Pt 1 G895-G899

Role of vagal and splanchnic capsaicin-sensitive afferents in enterogastric inhibition of acid secretion in rats.

2009-05-01T00:30:59Z

The role of capsaicin-sensitive afferent innervation and neural pathways involved in the enterogastric inhibition of gastric acid secretion by luminal acid was investigated in urethan-anesthetized rats. Intestinal perfusion with graded concentrations of HCl (50, 75, and 100 mM) for 1 h dose dependently inhibited both thyrotropin-releasing hormone (TRH) analogue- and pentagastrin-stimulated acid ou...

E Saperas, J Santos, J R Malagelada (1995) Am J Physiol 268: 2 Pt 1 G286-G291

Intravenous cyclosporine for steroid-refractory attacks of Crohn's disease. Short- and long-term results.

2009-05-01T00:36:44Z

A prospective, open trial was conducted to test whether i.v. cyclosporine was effective in the treatment of refractory Crohn's disease. Eight patients with acute steroid-refractory attacks were included. Intravenous cyclosporine, 5 mg/kg/day, was added to ongoing drug therapy. Patients who responded were then switched to oral cyclosporine for a mean 2.6-month period, and steroids were discontinued...

J V Santos, J A Baudet, F J Casellas, L A Guarner, J M Vilaseca, J R Malagelada (1995) J Clin Gastroenterol 20: 3 207-210

Efficacy of intravenous cyclosporine for steroid refractory attacks of ulcerative colitis.

2009-05-01T00:36:44Z

The use of cyclosporine in refractory ulcerative colitis (UC) is still controversial. An 8-year-long retrospective review open-label treatment with intravenous cyclosporine in 21 patients with steroid-refractory UC is therefore in order. Intravenous cyclosporine, 5 mg/kg-1 day, was added to ongoing drug therapy. Those who responded were switched to oral cyclosporine for a mean 8.4-month period, an...

J Santos, S Baudet, F Casellas, L Guarner, J Vilaseca, J R Malagelada (1995) J Clin Gastroenterol 20: 4 285-289

Eosinophilic gastroenteritis presenting as ascites and splenomegaly.

2009-05-01T00:35:48Z

A 25-year-old man with a 1 year history of episodic abdominal pain presented with splenomegaly, eosinophilic ascites and peripheral eosinophilia. Full-thickness biopsies from his gastrointestinal tract revealed intense eosinophilic infiltration involving both muscular and serosal layers and extending from his stomach to his ileum. When given oral steroids, the patient's condition improved and he w...

J Santos, F Junquera, I de Torres, X Molero, J Vilaseca, J R Malagelada (1995) Eur J Gastroenterol Hepatol 7: 7 675-678

Estrogen and progestagen treatment in digestive hemorrhage caused by vascular malformations

2009-05-01T00:30:59Z

The efficacy of an association of estrogens and progestagens in the treatment of gastrointestinal bleeding by angiodysplasia was analyzed. Thirty-three patients with gastrointestinal bleeding due to vascular malformations were admitted from January 1986 to December 1993. Fifteen of the 33 patients were submitted to surgical or endoscopic treatment. The remaining 18 patients underwent daily oral tr...

F Junquera, J Santos, E Saperas, J R Armengol, J R Malagelada (1995) Gastroenterol Hepatol 18: 2 61-65

Pharmacologic treatment of digestive hemorrhage caused by gastroduodenal mucosal lesions

2009-05-01T01:11:36Z

F J Santos Vicente, F Mearin Manrique (1994) Med Clin (Barc) 102: 18 703-707

Hepatocellular carcinoma with hepatitis C antibody positivity in a male with porphyria cutanea tarda

2009-05-01T00:32:10Z

J Santos Vicente, J M Suriñach Caralt, P Blanch, A Mirada Canals (1992) Med Clin (Barc) 98: 14

Non-functioning endocrine tumor of the pancreas

2009-05-01T00:43:03Z

J Santos, X Borrellas, O Gallego, A Nadal, C Margarit, L Guarner (1991) Rev Esp Enferm Dig 80: 2 145-147

Porphyria cutanea tarda

2009-05-01T00:32:10Z

J Santos Vicente, L Lu Cortez, R Enríquez de Salamanca (1991) An Med Interna 8: 4 159-160