http://publicationslist.org/data/jayesh.kattla/atom.xmlJayesh Kattla's Publications List Jayesh Kattlahttp://publicationslist.org/jayesh.kattla$basepathfavicon.icoRecent additions to Jayesh Kattla's PublicationsList.org pagehttp://publicationslist.org/publications.png2010-02-04T15:54:20Z http://publicationslist.org/jayesh.kattla/refid1 2010-02-04T15:53:56Z Allelic depletion of grem1 attenuates diabetic kidney disease. OBJECTIVE: Gremlin (grem1) is an antagonist of the bone morphogenetic protein family that plays a key role in limb bud development and kidney formation. There is a growing appreciation that altered grem1 expression may regulate the homeostatic constraints on damage responses in diseases such as diabetic nephropathy. RESEARCH DESIGN AND METHODS: Here we explored whether knockout mice heterozygous f...<br/><br/>Sarah A Roxburgh, Jayesh J Kattla, Simon P Curran, Yvonne M O'Meara, Carol A Pollock, Roel Goldschmeding, Catherine Godson, Finian Martin, Derek P Brazil (2009) <i>Diabetes</i> <i></i> <i></i> 58: 7 1641-1650<br/> http://publicationslist.org/jayesh.kattla/refid2 2010-02-04T15:53:56Z Protein kinase B/Akt activity is involved in renal TGF-beta1-driven epithelial-mesenchymal transition in vitro and in vivo. The molecular pathogenesis of diabetic nephropathy (DN), the leading cause of end-stage renal disease worldwide, is complex and not fully understood. Transforming growth factor-beta (TGF-beta1) plays a critical role in many fibrotic disorders, including DN. In this study, we report protein kinase B (PKB/Akt) activation as a downstream event contributing to the pathophysiology of DN. We investigate...<br/><br/>Jayesh J Kattla, Rosemarie M Carew, Mediha Heljic, Catherine Godson, Derek P Brazil (2008) <i>Am J Physiol Renal Physiol</i> <i></i> <i></i> 295: 1 F215-F225<br/> http://publicationslist.org/jayesh.kattla/refid3 2010-02-04T15:53:56Z Enhanced sensitivity of protein kinase B/Akt to insulin in hypoxia is independent of HIF1alpha and promotes cell viability. Maintenance of oxygen homeostasis is a key requirement to ensure normal mammalian cell growth and differentiation. Hypoxia arises when oxygen demand exceeds supply, and is a feature of multiple human diseases including stroke, cancer and renal fibrosis. We have investigated the effect of hypoxia on kidney cells, and observed that insulin-induced cell viability is increased in hypoxia. We have char...<br/><br/>Robert E Barry, Bernard B Allan, Eoin P Cummins, Jayesh J Kattla, Aoife Giblin, Niamh Scally, Cormac T Taylor, Derek P Brazil (2007) <i>Eur J Cell Biol</i> <i></i> <i></i> 86: 7 393-403<br/>