Jubbin Jacob's Publications List

Hyperosmolar Hyperglycemic Non Ketotic coma and Rhabdomyolysis; An uncommon clinical encounter.

2009-08-22T13:39:32Z

Philip C, Jacob JJ, Gupta S. (2009) Libyan J Med. 4: 4

Effects of pioglitazone on menstrual frequency, hyperandrogenism and insulin resistance in adoloscents and young adults with polycystic ovary syndrome.

2009-04-11T16:32:13Z

STUDY OBJECTIVE: To study the clinical, metabolic and adverse effects of pioglitazone over a period of 6 months in obese adolescent and young adults with polycystic ovary syndrome. DESIGN: This was an open labeled study. Each patient served as her own control. SETTING: Outpatient department of a university affiliated teaching hospital. PARTICIPANTS: Unmarried women (age 15-25 yrs) with chronic ano...

Laddiperla Narsing Rao, Jubbin Jagan Jacob, Thomas V Paul, Simon Rajarathinam, Nihal Thomas, Mandalam S Seshadri (2009) J Pediatr Adolesc Gynecol 22: 2 91-95

Respiratory changes in Prader-Willi syndrome.

2009-04-11T16:37:50Z

V M dos Santos, F H de Paula, J A S Filho ; Authors reply J J Jacob, T V Paul (2009) Singapore Med J 50: 1

Visual vignette. Solitary sacral metastasis from a malignant paraganglioma.

2008-02-05T03:05:46Z

Suresh Prabhu, Jubbin Jagan Jacob, Nihal Thomas, Regi Oommen (2008) Endocr Pract 14: 1 131-131

Levofloxacin and hypoglycemia.

2008-05-09T03:03:02Z

Navjot Singh, Jubbin Jagan Jacob (2008) Clin Infect Dis 46: 7 1127-1127

Management of insulinomas: analysis from a tertiary care referral center in India.

2008-04-22T02:10:27Z

The aim of this study was to describe the localization and management of patients with pancreatic insulinomas and determine the most effective localization and surgical techniques in the presence of significant financial constraints in the patient population. We retrospectively reviewed the case records of 18 patients with insulinomas treated at our institution over a period of 10 years. The medic...

Thomas V Paul, Jubbin J Jacob, Senthil K Vasan, Nihal Thomas, Simon Rajarathnam, Ben Selvan, M J Paul, Deepak Abraham, Aravindan Nair, M S Seshadri (2008) World J Surg 32: 4 576-582

Primary hyperparathyroidism and chronic pancreatitis.

2008-01-04T12:09:51Z

Jubbin J Jacob, Ashok Chacko, Ben Selvan, Nihal Thomas (2008) J Gastroenterol Hepatol 23: 1 164-164

Bilateral maxillary brown tumours as the first presentation of primary hyperparathyroidism.

2008-07-26T03:59:52Z

INTRODUCTION: Symptomatic skeletal disease in primary hyperparathyroidism is over 30 times more common in India compared to the west. The classical "brown tumour" is commonly seen with the major sites being ends of long bones, the pelvis and ribs. Facial involvement is rare and, when present, usually involves the mandible. CASE REPORT: We report a 68-year-old gentleman with a rare initial presenta...

Felix Jebasingh, Jubbin Jagan Jacob, Apoorva Shah, Thomas V Paul, Mandalam S Seshadri (2008) Oral Maxillofac Surg 12: 2 97-100

Foreign body aspiration in a boy with Prader-Willi Syndrome.

2008-01-23T14:06:47Z

A five-year-old boy presented with progressive weight gain with effort intolerance and nocturnal symptoms suggesting obstructive sleep apnoea. A clinical diagnosis of Prader-Willi Syndrome was made. As the initial radiography and computed tomography suggested a foreign body, bronchoscopy was done under general anaesthesia and impacted peanuts were removed from the left main bronchus. His symptoms ...

S S Jacob, J J Jacob, T V Paul (2008) Singapore Med J 49: 1 e12-e14

Fatal hypoglycemia with levofloxacin use in an elderly patient in the post-operative period.

2008-04-22T02:11:17Z

BACKGROUND AND AIM: Fluoroquinolones are antimicrobial agents with a broad spectrum of activity against gram-positive, gram-negative, and anaerobic organisms. They are widely used in surgical practice and are generally considered safe. Hypoglycemia because of use of levofloxacin is a rarely reported complication. This report of a case of a surgical patient highlights this potentially fatal complic...

Madhurita Singh, Jubbin Jagan Jacob, Rajeev Kapoor, John Abraham (2008) Langenbecks Arch Surg 393: 2 235-238

Diabetes and Exercise,

2008-10-04T07:57:19Z

JJ Jacob and A Keats (2008) A Practical Guide to Diabetes Mellitus, 4th Edition, 32-40

Medical image. An incidental thoracic mass.

2008-10-29T02:50:39Z

Philip N Finny, Jubbin J Jacob (2008) N Z Med J 121: 1284 87-88

Nephropathy in Diabetes,

2008-10-04T08:02:32Z

Anjali and JJ Jacob (2008) A Practical Guide to Diabetes Mellitus, 4th Edition, 146-153

Emergencies in Diabetes - Hyperglycemia and Hypoglycemia,

2008-10-04T08:01:29Z

J J Jacob (2008) A Practical Guide to Diabetes Mellitus, 4th Edition, 198-209

Hypertension in Diabetes,

2008-10-04T08:02:01Z

Anjali and JJ Jacob (2008) A Practical Guide to Diabetes Mellitus, 4th Edition, 138-145

The Foot in Diabetes,

2008-10-04T07:58:37Z

D Abraham, E Stephen, JJ Jacob, R Cherian, N Thomas (2008) A Practical Guide to Diabetes Mellitus, 4th Edition, 97-113

Tumoral calcinosis of the scalp: An unusual site for a rare tumor.

2007-09-02T07:29:45Z

Tumoral calcinosis is a rare calcifying disorder that is associated with deposition of calcium crystals in the periarticular tissues. The mass is most often around the hips, elbows, shoulders, and feet but may be occasionally found elsewhere. We report a case of multiple sporadic tumoral calcinoses in an adult male over the scalp. The scalp as a site of tumoral calcinosis has not been previously r...

Jubbin Jagan Jacob, Nihal Thomas, M S Seshadri (2007) Laryngoscope 117: 1 179-180

Medullary thyroid carcinoma: a 20-year experience from a centre in South India.

2007-09-02T07:27:08Z

BACKGROUND: Management of medullary thyroid carcinoma (MTC) remains controversial despite many advances over the past five decades. We attempt to review the presentation, management and prognosis of MTC at our institution over the last two decades. METHODS: We conducted a retrospective review of the records of 40 patients with MTC over a period of 20 years. RESULTS: Ten patients had hereditary MTC...

Philip Finny, Jubbin J Jacob, Nihal Thomas, Jim Philip, Simon Rajarathnam, Regi Oommen, Aravindan Nair, Mandalam S Seshadri (2007) ANZ J Surg 77: 3 130-134

Clinical Vignette. Recurrent Vomiting in a patient with Thyrotoxicosis.

2007-09-02T07:49:11Z

Vomiting as a predominant presenting symptom is unusual in thyrotoxicosis. Various mechanisms have been proposed for this presentation. We present the case record of a 62 year old lady with thyrotoxicosis and recurrent vomiting. During the course of her evaluation we uncovered multiple reasons for her presenting symptoms.

Jacob JJ and Thomas N. (2007) Curr Med Iss 9: 3 26-7

A man with painless haematuria and hypertension.

2007-09-02T07:25:12Z

A 35-year-old male presented with right loin pain and two episodes of painless haematuria. At the age of 27,the patient had surgery for a left cerebellar astrocytoma followed by 6 weeks of radiation therapy. He had been asymptomatic for the last 8 years. On examination he was found to have hypertension and a palpable mass in the right lumbar region. Computed tomographic scans of the abdomen were p...

Jubbin J Jacob, Thomas V Paul (2007) Hong Kong Med J 13: 2 162-163

Patient Vignette; Pituitary Hyperplasia

2007-09-02T07:51:04Z

The widespread use of Magnetic Resonance Imaging (MRI) has resulted in the discovery of unsuspected endocrinologically silent masses in the pituitary gland (pituitary incidentalomas). Pituitary enlargement in patients with long-standing primary hypothyroidism is well established and is reported to correlate with circulating thyrotropin levels. We report two cases where the discovery of pituitary ...

Jacob JJ, Thomas N and Chacko A. (2007) Curr Med Iss 9: 1 42-43

A Palpable nodule is the only significant Preoperative clue in the Diagnosis of Parathyroid Carcinoma In India - A case series

2007-09-02T08:01:01Z

INTRODUCTION: Parathyroid tumours account for a very small percentage of all head and neck neoplasms. The clinical presentation of benign primary hyperparathyroidism differs from that seen in Western series. We attempt to review the presentation and outcomes of patients treated for malignant primary hyperparathyroidism from our centre and highlight the clinical clues to a early pre-operative diagn...

K Senthil Vasan, Jacob JJ, Abraham DT,Selvan B, Paul MJ, Nair A, Oommen R, Thomas N & Seshadri M S. (2007) 5th Winter Symposium- Endocrinology, Diabetes and Metabolism 184-185

Visual vignette. Tuber cinereum hamartoma.

2007-09-02T10:02:28Z

A 5 year old boy was brought to us because his parents had noticed a rapid increase in his height over the last 2 years with deepening of his voice in the last one year and premature maturation of his genitalia in the last 6 months. On examination he was 137cm tall, which was much above the 97th percentile for his age with a height SD Score of +2.5 SD. He had well developed muscles and weighed 30k...

Jubbin Jagan Jacob, Thanuvellil George Koshy, Thomas V Paul (2007) Endocr Pract 13: 2

Medullary thyroid carcinoma.

2007-09-02T07:06:37Z

Thomas N, Jacob JJ. (2007) ANZ J Surg. 77: 8 705

Influence of Dietary Calcium and Vitamin D Status on Bone Mineral density and the prevalence of Osteoporosis in Ambulant Post menopausal Women from a Semi Urban region in South India,

2007-09-02T08:05:10Z

Paul TV, Jacob JJ, Sudeep K, Thomas N, Seshadri M S, Charles S, Jose A, Oommen R & Mahendri. (2007) 5th Winter Symposium- Endocrinology, Diabetes and Metabolism 171

Oncogenic osteomalacia.

2007-09-02T07:09:24Z

A 59-year-old gentleman presented with symptoms of progressively worsening low back pain associated with difficulty in rising from a squat over a period of two years. Biochemical tests confirmed the initial clinical diagnosis of osteomalacia. Blood pool scanning revealed a focal hot spot on the site of the clinically visible swelling close to the metacarpo-phalangeal joint of the left index finger...

J J Jacob, P Finny, Meera Thomas, N Thomas, M John (2007) J Assoc Physicians India 55: 231-233

Visual vignette. Albright-McCune syndrome.

2007-09-02T08:50:38Z

A five and half year old girl child presented to us with history of onset of menarche at the age of 4 years with bilateral lower limb pain over twelve months. Historically she had been born to non-consanguineous parents at term. She had no previous medical illnesses and no prior history of any medications. Physical examination revealed a normal statured (height standard deviation score of plus 1.3...

Senthil K Vasan, Jubbin Jagan Jacob, Mandalam S Seshadri (2007) Endocr Pract 13: 2

Plasmacytoma mimicking mediastinal parathyroid tumour in a patient with primary hyperparathyroidism.

2007-09-02T07:20:07Z

The association of monoclonal gammopathies with primary hyperparathyroidism is well documented. Many case reports have documented the coexistence of primary hyperparathyroidism and multiple myeloma. The cause of this relationship is not known. We report the case of a 49-year-old gentleman who was treated for primary hyperparathyroidism. His initial preoperative nuclear scan had shown persistent ac...

Jubbin Jagan Jacob, Mathew John, Meera Thomas, Nihal Thomas, Aravindan Nair (2007) Asian J Surg 30: 2 147-150

Idiopathic sporadic tumoral calcinosis of the hip: successful oral bisphosphonate therapy.

2007-09-02T07:16:05Z

OBJECTIVE: To report the case of a woman with idiopathic sporadic tumoral calcinosis treated successfully with orally administered bisphosphonates. METHODS: We report the clinical, laboratory, and imaging findings and describe the clinical course of tumoral calcinosis. The literature was reviewed for the pathophysiologic features and strategies for treatment of tumoral calcinosis. In addition, we ...

Jubbin Jagan Jacob, Kusum Mathew, Nihal Thomas (2007) Endocr Pract 13: 2 182-186

Intracardiac blood-filled cysts of the heart: a rare cause of embolic stroke.

2007-09-02T07:21:40Z

Intracardiac blood cysts are thin-walled congenital cysts located in the endocardium and are seen predominantly in infants. They are rare in adults and are typically asymptomatic. However, complications such as valve dysfunction and left ventricular outflow tract obstruction have been reported in adults. We report a 42-year-old woman who developed an embolic stroke in association with intracardiac...

J J Jacob, J Jose, B John (2007) Singapore Med J 48: 5 e125-e126

Diabetes and Exercise.

2007-09-02T10:44:15Z

The adoption of a sedentary lifestyle is a clear factor in the development of Type 2 Diabetes Mellitus. The accumulation of the excess energy stores into the muscle cells and liver as free fatty acids and glycogen results in Insulin resistance. The clinician can increase the chances of the patient "buying into" the exercise regimen by asking the patient to set his own exercise goals. Although it ...

Jacob JJ (2007) A Practical Guide to Diabetes Mellitus., 3rd Edition 22-27

Emergencies in Diabetes - Hypoglycaemia.

2007-09-02T10:45:03Z

Hypoglycaemia is defined by a serum glucose level of less than 50 mg/dL. The glucose level at which an individual becomes symptomatic is highly variable. A delay in treatment can result in profound sequlae. Treatment should not be withheld while waiting for a laboratory glucose value. The brain uses glucose as its primary energy source hence neuronal damage may occur if treatment of hypoglycaemia ...

Jacob JJ (2007) A Practical Guide to Diabetes Mellitus., 3rd Edition, 132-135

Emergencies in Diabetes – Hyperglycaemia.

2007-09-02T10:44:39Z

Diabetic ketoacidosis (DKA) is a state of absolute or relative insulin deficiency aggravated by ensuing hyperglycemia, dehydration, and acidosis-producing derangements in intermediary metabolism. The most common causes are underlying infection, disruption of insulin treatment, and new onset of diabetes. DKA is typically characterized by hyperglycemia over 300 mg/dL, low bicarbonate (<15 mEq/L), an...

Jacob JJ (2007) A Practical Guide to Diabetes Mellitus., 3rd Edition, 124-131

A boy with a limp. Slipped capital femoral epiphysis.

2007-09-05T02:23:34Z

Jubbin Jacob, Thomas Paul (2007) N Z Med J 120: 1250 U 2447

Perrault syndrome with marfanoid habitus in two siblings.

2007-11-01T17:27:03Z

BACKGROUND: Familial pure gonadal dysgenesis with 46 XX karyotype and sensorineural deafness constitutes a rare autosomal recessive syndrome described initially by Perrault in 1951. The spectrum of the disease remains undetermined. Families with additional newer findings are regularly reported. CASE: We report two siblings with gonadal dysgenesis, progressive sensorineural deafness, Marfanoid body...

Jubbin J Jacob, Thomas V Paul, Suma S Mathews, Nihal Thomas (2007) J Pediatr Adolesc Gynecol 20: 5 305-308

Primary hyperparathyroidism presenting as redness of eyes.

2007-12-07T15:07:38Z

A 38 year old gentleman presented with redness of both eyes of 15 days duration associated with severe bifrontal, non-throbbing headache. Ophthalmological evaluation revealed bilateral scleritis and retinal haemorrhage in the supero-temporal quadrant. He also had hyperuricemia and was referred to our institution with the suspicion of a haematological malignancy. Biochemical investigations done by...

Philip Finny, Jubbin J Jacob, Nihal Thomas (2007) Eur J Intern Med 18: 8 608

Medical image. Dense bones and brain stones. Carbonic anhydrase-II (CA-II) deficiency.

2007-09-25T18:44:46Z

A 4-year-old boy presented with delay in developmental milestones and aggressive behavior. An axial CT scan of the brain was done. Subsequent evaluation revealed normal serum calcium and inorganic phosphorus values with an elevated serum alkaline phosphatase. His arterial blood gas analysis was suggestive of metabolic acidosis with anionic gap of minus 15.1. His skeletal X-rays were done.

Suresh Prabhu, Jubbin J Jacob, Nihal Thomas (2007) N Z Med J 120: 1262

OUTCOMES FOLLOWING FIXED DOSE I-131THERAPY FOR GRAVES’DISEASE(GD)AND A LOW IODINE DIET

2007-09-02T10:30:47Z

Objective: To study the clinical outcomes in terms of thyroid functions and overall cure rates at 3 and 6 months after fixed dose I-131 therapy for Graves’ disease with an iodine restricted diet. Methods: Consecutive adult patients with GD planned for I-131 therapy were block randomized either to receive instructions regarding dietary iodine restriction or no advice prior to fixed dose ...

Jubbin Jagan Jacob, Regi Oommen, Charles Stephen, and Mandalam S. Seshadri. (2007) Abstract #278. Thyroid diseases 74-75

PERRAULT SYNDROME (GONADAL DYSGENESIS WITH SENSORINEURAL DEAFNESS) IN TWO SIBLINGS

2007-09-02T10:25:41Z

Objective: To report two siblings with Perrault syndrome and marfanoid body proportions expanding the spectrum of the disease. Case Presentation: The older of the siblings presented initially with hearing loss related to bilateral Sensorineural deafness (SND) (Figure 1). A year later she presented with primary amenorrhea and failure to develop any secondary sexual characteristics. Investiga...

Jubbin Jagan Jacob, Thomas V. Paul,Suma S. Mathews, and Nihal Thomas (2007) Abstract #274. Reproductive Endocrinology 71-72

Management of Diabetic Ketoacidosis.

2007-09-02T11:07:34Z

Jacob JJ. (2006) Curr Med Iss 8: 3 8

Parathyroid scintigraphy for hyperparathyroidism, an assessment of performance

2007-09-02T11:11:55Z

Aims: To calculate the sensitivity, specificity and positive predictive value of Parathyroid scintigraphy using Technetium-Sestamibi scan in the localization of parathyroid disease. Methods and material: This is a retrospective medical review of 161 patients who underwent the Parathyroid scintigraphy at our hospital in last six years. True positives were defined as patients with confirmed prim...

Thomas VP, Thomas N, Seshadri MS, Rajarathinam S, Sudeep K & Jacob JJ. (2006) Endo Abstracts 11: P 440

Primary Hyperparathyroidism (PHPT) in India; a Clinically Overt Disease with Long Term Implications.

2007-09-02T08:30:57Z

Context : Primary Hyperparathyroidism (PHPT) in India and in other developing countries is still recognized by its classic manifestations1,2,3. A significant proportion of patients with PHPT with symptomatic disease have long term sequelae of the disease some of which require lifelong therapy in addition to the removal of the tumour. Objectives : We describe data from 111 patients with PHPT see...

Jubbin J Jacob, Nihal J Thomas, Ben Selvan, Aravindan Nair, Regi Oommen, Simon Rajarathanam, Mandalam S Seshadri (2006) POSTER SESSION: CLINICAL - Primary Hyperparathyroidism & Other Metabolic Bone Diseases P1-775

Does hyperparathyroidism cause pancreatitis? A South Indian experience and a review of published work.

2007-09-02T07:31:59Z

BACKGROUND: The association between pancreatic disease and primary hyperparathyroidism (PHPT) is controversial. We attempt to suggest a causal correlation and characterize the nature of pancreatic disease in PHPT. METHODS: This study is a retrospective review of the medical records of patients who were diagnosed with PHPT and presented with pancreatic disease between 1 May 2000 and 30 May 2005 at ...

Jubbin J Jacob, Mathew John, Nihal Thomas, Ashok Chacko, Rekha Cherian, Ben Selvan, Aravindan Nair, Mandalams Seshadri (2006) ANZ J Surg 76: 8 740-744

Management of Thyroid Cancers.

2007-12-07T15:10:33Z

Papillary and follicular (differentiated) carcinomas of the thyroid are among the most curable cancers and together with medullary carcinoma and anaplastic carcinoma of the thyroid account for around 1% of all human cancers.

Jacob JJ, Thomas N, Sudeep K, Finney P, Selvan B, Nair A, Oommen R and Seshadri MS. (2006) Curr Med Iss 8: 3 40-44

Pancreatitis In Primary Hyperparathyriodism - Causal Or Casual?

2007-09-02T10:12:11Z

Aim; To characterize the clinical features, biochemistry and imaging features of pancreatic disease in primary hyperparathyroidism ( PHPT) Methods; This study is a retrospective medical record review of thirteen patients who were diagnosed with primary hyperparathyroidism and presented with pancreatic disease among a total of 102 patients with a diagnosis of Primary hyperparathyroidism at Chris...

Abraham D, Jacob JJ and Thomas N (2006) 10th Congress of the Asian Association of Endocrine Surgeons

Medical image. A fragile adolescent.

2007-09-02T08:48:34Z

A 17 year old boy presented with history of fracture of the left humerus sustained on minimal trauma (Figure 1). There was previous history of multiple episodes of pathological fractures with deformities since childhood. Radiological survey of the patient revealed multiple expansile lesions in various long bones. (Figure 2 & 3). Further physical examination revealed a dark brown hyperpigmented le...

Jubbin J Jacob, Suceena Alexander, Nihal Thomas (2006) N Z Med J 119: 1237

Characterstics of pancreatic disease in primary hyperparathyroidism

2007-09-02T10:11:18Z

Aim; To characterize the clinical features, biochemistry and imaging features of pancreatic disease in primary hyperparathyroidism ( PHPT) Methods; This study is a retrospective medical record review of thirteen patients who were diagnosed with primary hyperparathyroidism and presented with pancreatic disease among a total of 102 patients with a diagnosis of Primary hyperparathyroidism at Chris...

Jacob JJ, John M, Thomas N, Chacko A, Cherian R, Selvan B, Nair A, Seshadri MS (2005) 35th Annual Conference of Endocrine Society of India

Sestamibi Scan For Hyperparathyroidism An Assessment Of Performance

2008-04-22T02:12:04Z

Objectives : To calculate the sensitivity, specificity and positive predictive value of 99 Tc Sestambi scan in the localization of parathyroid disease and to calculate the cost benefit of routine pre-operative scan. Methods : This is a retrospective medical review of 161 patients who underwent the 99 Tc Sestambi scan at Christian Medical College and Hospital Vellore, India between 1st May 2000...

Jubbin Jacob, Mathew John, Nihal Thomas, Regi Oomen, Nylla Shantly, Arvindan Nair and M.S. Seshadri (2005) 2005 Congress of The ASEAN Federation of Endocrine Societies S 86

The Aetiological, Clinical And Metabolic Profile Of Hypokalemic Periodic Paralysis In An Indian Population

2007-09-02T18:03:39Z

Objective Hypokalemic periodic paralysis (HPP) represents a heterogeneous group of disorders that presents with acute muscular weakness. Familial periodic paralysis is the commonest cause of hypokalemic periodic paralysis in Caucasians and thyrotoxic paralysis in the Orientals. In this analysis, we have complied the etiological factors that appear to be more dominant in Indian population. ...

Jubbin Jacob, Narsing Rao, Mathew John, Simon Rajaratnam , Nihal Thomas , M.S.Seshadri (2005) 2005 Congress of The ASEAN Federation of Endocrine Societies S 114

Insulinomas- An Expereince From South India

2007-09-02T10:09:31Z

Background: Insulinoma is a disorder affecting one in 100,000 of the general population. The clinical profile of insulinomas among Indian patients has not been characterized. Aim of the study: To study the clinical characteristics, biochemical and radiological parameters and treatment aspects of adult patients with insulinomas. Methodology: A retrospective analysis of 18 patients with insu...

Thomas V Paul, Ben Selvan, Jubbin Jacob, Aravindan Nair, Senthil Vasan K, Esther Evelyn J, Nihal Thomas, Simon Rajarathinam, M.S.Seshadri (2005) 2005 Congress of The ASEAN Federation of Endocrine Societies S 67