http://publicationslist.org/data/keita.kirito/atom.xml Keita Kiritohttp://publicationslist.org/keita.kirito$basepathfavicon.icoRecent additions to Keita Kirito's PublicationsList.org pagehttp://publicationslist.org/publications.png2009-07-12T11:09:23Z http://publicationslist.org/keita.kirito/refid5 2008-12-31T07:54:53Z

We describe a Japanese family with familial platelet disorder with propensity to develop myeloid malignancies (FPD/MM). Among the three affected individuals, two members developed myeloid malignancies. Sequence studies demonstrate that all affected individuals of the pedigree display a heterozygous single nucleotide deletion in exon 8 of the RUNX1 gene.<br/><br/>Keita Kirito, Kumi Sakoe, Daisuke Shinoda, Yoshihisa Takiyama, Kenneth Kaushansky, Norio Komatsu (2008) <i>Haematologica</i> <i></i> <i></i> 93: 1 155-156<br/>

http://publicationslist.org/keita.kirito/refid3 2008-12-31T07:54:53Z

Toru Sanmori, Kei Nakashima, Yumi Nozaki, Takahiro Nagashima, Masae Kunitama, Keita Kirito, Norio Komatsu (2008) <i>Rinsho Ketsueki</i> <i></i> <i></i> 49: 1 1-2<br/>

http://publicationslist.org/keita.kirito/refid2 2008-12-31T07:54:53Z

Hypoxia inducible factor (HIF)-1 is a master transcriptional regulator mediating the cellular adaptation to hypoxia. In addition, HIF-1 is also vital for the development of hematopoietic stem cells (HSCs). In a previous study we found that thrombopoietin (TPO), an important and non-redundant cytokine for HSC maintenance and expansion, induces HIF-1alpha expression in HSCs by enhancing the stabilit...<br/><br/>Kozue Yoshida, Keita Kirito, Hu Yongzhen, Keiya Ozawa, Kenneth Kaushansky, Norio Komatsu (2008) <i>Int J Hematol</i> <i></i> <i></i> 88: 1 43-51<br/>

http://publicationslist.org/keita.kirito/refid1 2008-12-31T07:54:53Z

We evaluated the long-term outcome of very dose-intensive chemotherapy (TCC-NHL-91) for advanced intermediate-grade lymphoma, in which an eight-cycle regimen with 11 drugs was given with granulocyte colony-stimulating factor (G-CSF) support (total 18 weeks). Fifty-nine patients were treated during February 1, 1991 and March 31, 2001 (median age: 48 years). Forty-three patients (73%) were in a high...<br/><br/>Miyuki Akutsu, Saburo Tsunoda, Tohru Izumi, Masaru Tanaka, Susumu Katano, Koichi Inoue, Seiji Igarashi, Kaoru Hirabayashi, Yusuke Furukawa, Ken Ohmine, Kazuya Sato, Hiroyuki Kobayashi, Keiya Ozawa, Keita Kirito, Takahiro Nagashima, Satoshi Teramukai, Masanori Fukushima, Yasuhiko Kano (2008) <i>Oncol Res</i> <i></i> <i></i> 17: 3 137-149<br/>

http://publicationslist.org/keita.kirito/refid8 2008-12-31T07:54:53Z

FMS-like tyrosine kinase-3 (FLT3) is a new therapeutic target for acute myelocytic leukemia (AML), because FLT3 mutations are the most common genetic alterations in AML and are directly related to leukemogenesis. We studied cytotoxic interactions of a FLT3 inhibitor, PKC412, with eight conventional antileukemic agents (cytarabine, doxorubicin, idarubicin, mitoxantrone, etoposide, 4-hydroperoxy-cyc...<br/><br/>Y Furukawa, H A Vu, M Akutsu, T Odgerel, T Izumi, S Tsunoda, Y Matsuo, K Kirito, Y Sato, H Mano, Y Kano (2007) <i>Leukemia</i> <i></i> <i></i> 21: 5 1005-1014<br/>

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FKHRL1 (also called FOXO3a) is a member of the Forkhead Box, class O (FOXO) subfamily of forkhead transcription factors and functions downstream of Bcr-Abl tyrosine kinase as a phosphorylated inactive form in chronic myelogenous leukemia (CML). The Bcr-Abl tyrosine kinase inhibitor imatinib induces cell cycle arrest and subsequent apoptosis via the conversion of FKHRL1 from the phosphorylated inac...<br/><br/>Satoru Kikuchi, Tadashi Nagai, Masae Kunitama, Keita Kirito, Keiya Ozawa, Norio Komatsu (2007) <i>Cancer Sci</i> <i></i> <i></i> 98: 12 1949-1958<br/>

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Tetsu Mitsumori, Yumi Nozaki, Kei Nakajima, Takahiro Nagashima, Mae Kunitama, Keita Kirito, Norio Komatsu (2007) <i>Rinsho Ketsueki</i> <i></i> <i></i> 48: 11 <br/>

http://publicationslist.org/keita.kirito/refid6 2008-12-31T07:54:53Z

FKHRL1 is one of the human homologues of DAF-16, which is concerned with longevity in Caenorhabditis elegans. Previously, we demonstrated that FKHRL1 functions downstream of Akt in erythropoietin (EPO) signaling and that it is directly phosphorylated by activated Akt. Because phosphorylated FKHRL1 loses its transcriptional activity and translocates into the cytoplasm, FKHRL1 appears to be nonfunct...<br/><br/>Mie Uchida, Keita Kirito, Hitoshi Endo, Keiya Ozawa, Norio Komatsu (2007) <i>Int J Hematol</i> <i></i> <i></i> 86: 4 315-324<br/>

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PURPOSE OF REVIEW: Thrombopoietin, the primary regulator of megakaryopoiesis, acts by modulating several nuclear transcription factors. This review focuses on recent studies that have provided new insights into the functional roles of these proteins. RECENT FINDINGS: Among the transcription factors responsible for megakaryopoiesis, important roles for the signal transducer and activator of transcr...<br/><br/>Keita Kirito, Kenneth Kaushansky (2006) <i>Curr Opin Hematol</i> <i></i> <i></i> 13: 3 151-156<br/>

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Thrombopoietin (TPO) is a pivotal and nonredundant hematopoietic cytokine, supporting the survival, self-renewal activity and proliferation of hematopoietic stem and progenitor cells, the growth and differentiation of megakaryocytes, and the functional activation of their progeny, blood platelets. TPO exerts these effects through regulating the abundance or subcellular localization of several tran...<br/><br/>Keita Kirito, Kenneth Kaushansky (2005) <i>Cell Cycle</i> <i></i> <i></i> 4: 12 1729-1731<br/>

http://publicationslist.org/keita.kirito/refid11 2008-12-31T07:54:53Z

Thrombopoietin (TPO), the primary regulator of thrombopoiesis, is also an important, nonredundant mediator of hematopoietic stem cell (HSC) development. For example, following transplantation, HSC expansion is approximately 15-fold more robust in normal than in Tpo(-/-) mice. Vascular endothelial growth factor (VEGF) also plays an important role in HSC development, where it acts in an intracellula...<br/><br/>Keita Kirito, Norma Fox, Norio Komatsu, Kenneth Kaushansky (2005) <i>Blood</i> <i></i> <i></i> 105: 11 4258-4263<br/>

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Members of the homeobox family of transcription factors are major regulators of hematopoiesis. Overexpression of either HOXB4 or HOXA9 in primitive marrow cells enhances the expansion of hematopoietic stem cells (HSCs). However, little is known of how expression or function of these proteins is regulated during hematopoiesis under physiological conditions. In our previous studies we demonstrated t...<br/><br/>Keita Kirito, Norma Fox, Kenneth Kaushansky (2004) <i>Mol Cell Biol</i> <i></i> <i></i> 24: 15 6751-6762<br/>

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Targeting BCR-ABL tyrosine kinase by treatment with the selective inhibitor imatinib (formerly STI571, Gleevec) has proved to be highly efficient for inhibiting leukemic growth in vitro. In addition, in clinical trials, imatinib has produced high response rates in patients with chronic myeloid leukemia (CML) in chronic phase and blastic crisis. However, episodes of severe cytopenia were also frequ...<br/><br/>Mie Uchida, Tomoko Watanabe, Masae Kunitama, Masaki Mori, Satoru Kikuchi, Kozue Yoshida, Keita Kirito, Tadashi Nagai, Keiya Ozawa, Norio Komatsu (2004) <i>Stem Cells</i> <i></i> <i></i> 22: 4 609-616<br/>

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Erythropoietin (EPO) can rescue erythroid cells from apoptosis during erythroid development, leading to red cell production. However, the detailed mechanism of how EPO protects erythroid cells from apoptosis is still open to question. To address this problem, we used a human EPO-dependent leukemia cell line UT-7/EPO and normal erythroid progenitor cells. After deprivation of EPO, UT-7/EPO cells un...<br/><br/>Masaki Mori, Mie Uchida, Tomoko Watanabe, Keita Kirito, Kiyohiko Hatake, Keiya Ozawa, Norio Komatsu (2003) <i>J Cell Physiol</i> <i></i> <i></i> 195: 2 290-297<br/>

http://publicationslist.org/keita.kirito/refid17 2008-12-31T07:54:53Z

A member of the Forkhead transcription factor family, FKHRL1, lies downstream of the phosphatidylinositol 3-kinase-Akt activation pathway in cytokine signaling. Because the phosphatidylinositol 3-kinase-Akt activation pathway is required for BCR-ABL-mediated transformation and survival signaling in chronic myelogenous leukemia (CML), in this study we examined the involvement of FKHRL1 in the BCR-A...<br/><br/>Norio Komatsu, Tomoko Watanabe, Mie Uchida, Masaki Mori, Keita Kirito, Satoru Kikuchi, Qifa Liu, Tetsuzo Tauchi, Keisuke Miyazawa, Hitoshi Endo, Tadashi Nagai, Keiya Ozawa (2003) <i>J Biol Chem</i> <i></i> <i></i> 278: 8 6411-6419<br/>

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Thrombopoietin (TPO), the primary regulator of platelet production, also plays an important role in hematopoietic stem cell (HSC) biology. In previous studies we demonstrated that the self-renewal and expansion of HSCs is 10 to 20 times less robust in tpo-/- mice than in controls. To explore the molecular basis of this effect, we postulated that Hoxb4 might mediate at least part of the TPO effect ...<br/><br/>Keita Kirito, Norma Fox, Kenneth Kaushansky (2003) <i>Blood</i> <i></i> <i></i> 102: 9 3172-3178<br/>

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Thrombopoietin (TPO), an essential factor for megakaryopoiesis and thrombopoiesis, works as a survival factor for megakaryocytic lineage cells. However, little is known about the molecular mechanism in detail. We show here that TPO supports the survival of TPO-dependent leukemia cell line UT-7/TPO and normal megakaryocytic progenitors via the induction of Bcl-xL, an anti-apoptotic member of the Bc...<br/><br/>Keita Kirito, Tomoko Watanabe, Ken-ichi Sawada, Hitoshi Endo, Keiya Ozawa, Norio Komatsu (2002) <i>J Biol Chem</i> <i></i> <i></i> 277: 10 8329-8337<br/>

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The signal transducer and activator of transcription 3 (Stat3), a member of the Stat family of proteins, is commonly activated by thrombopoietic cytokines including thrombopoietin (TPO), interleukin (IL)-6, and interleukin-11. This finding strongly suggested that Stat3 has an important role in megakaryopoiesis and thrombopoiesis. To clarify the functional role of Stat3 in in vivo megakaryopoiesis ...<br/><br/>Keita Kirito, Masatake Osawa, Haruhiko Morita, Ritsuko Shimizu, Masayuki Yamamoto, Atsushi Oda, Hiroyoshi Fujita, Masaru Tanaka, Koichi Nakajima, Yasusada Miura, Keiya Ozawa, Norio Komatsu (2002) <i>Blood</i> <i></i> <i></i> 99: 9 3220-3227<br/>

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Signal transducers and activators of transcription (Stat) proteins play important roles in the regulation of hematopoiesis as downstream molecules of cytokine signal transduction. Previously, we demonstrated that Stat1 and Stat3 are activated by erythropoietin (EPO) in a human EPO-dependent erythroleukemia cell line UT-7/EPO. We report here that Stat1 and Stat3 are constitutively activated in fres...<br/><br/>Keita Kirito, Toshihiro Nagashima, Keiya Ozawa, Norio Komatsu (2002) <i>Int J Hematol</i> <i></i> <i></i> 75: 1 51-54<br/>

http://publicationslist.org/keita.kirito/refid25 2008-12-31T07:54:53Z

Signal transducers and activators of transcription (Stat) proteins play important roles in the regulation of hematopoiesis as downstream molecules of cytokine signal transduction. It was previously demonstrated that erythropoietin (EPO), a major regulator of erythropoiesis, activates 3 different Stat members, Stat1, Stat3, and Stat5, in a human EPO-dependent cell line, UT-7/EPO. To clarify the mec...<br/><br/>Keita Kirito, Koichi Nakajima, Tomoko Watanabe, Mie Uchida, Masaru Tanaka, Keiya Ozawa, Norio Komatsu (2002) <i>Blood</i> <i></i> <i></i> 99: 1 102-110<br/>

http://publicationslist.org/keita.kirito/refid19 2008-12-31T07:54:53Z

Keita Kirito, Norio Komatsu (2002) <i>Rinsho Ketsueki</i> <i></i> <i></i> 43: 4 278-281<br/>

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A 71-year-old man visited our hospital complaining of fever and a bleeding tendency. The peripheral blood WBC count was 10,400/microliter with 90% promyelocytes. The bone marrow was hypercellular with 88% promyelocytes. Disseminated intravascular coagulation was recognized. The patient was diagnosed as having acute promyelocytic leukemia and was treated with daily oral administration of all-trans ...<br/><br/>Takuji Miyoshi, Tetsuya Otsuki, Ken Omine, Keita Kirito, Tadashi Nagai, Tohru Izumi, Norio Komatsu, Seiji Madoiwa, Jun Mimuro, Yoichi Sakata, Keiya Ozawa (2002) <i>Rinsho Ketsueki</i> <i></i> <i></i> 43: 10 954-959<br/>

http://publicationslist.org/keita.kirito/refid21 2008-12-31T07:54:53Z

Phosphorylation of the Fanconi anemia complementation group A (FANCA) protein is thought to be important for the function of the FA pathway. However, the kinase for FANCA (so-called FANCA-PK) remains to be identified. FANCA has a consensus sequence for Akt kinase near serine 1149 (Ser1149), suggesting that Akt can phosphorylate FANCA. We performed in vitro kinase assays using as substrate either a...<br/><br/>Tetsuya Otsuki, Takahiro Nagashima, Norio Komatsu, Keita Kirito, Yusuke Furukawa, Shin-ichi Kobayashi Si, Johnson M Liu, Keiya Ozawa (2002) <i>Biochem Biophys Res Commun</i> <i></i> <i></i> 291: 3 628-634<br/>

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A 19-year-old male with de novo acute myeloid leukemia (AML) in complete remission received a bone marrow transplant from a HLA-matched donor. Because of major incompatibility for ABO blood type, bone marrow mononuclear cells of the donor were infused after conditioning including total body irradiation (TBI). Engraftment was confirmed on day +23. On day +91, recipient ABO blood genotype was detect...<br/><br/>Kazuo Muroi, Chizuru Kawano, Taiji Yokote, Tetsuya Otsuki, Keita Kirito, Norio Komatsu, Keiya Ozawa (2002) <i>Leuk Lymphoma</i> <i></i> <i></i> 43: 7 1493-1496<br/>

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Chronic myeloid leukemia (CML) is characterized by the clonal expansion of hematopoietic stem cells (HSCs). Without effective treatment, individuals in the indolent, chronic phase (CP) of CML undergo blast crisis (BC), the prognosis for which is poor. It is therefore important to clarify the mechanism underlying stage progression in CML. DNA microarray is a versatile tool for such a purpose. Howev...<br/><br/>K Ohmine, J Ota, M Ueda, S Ueno, K Yoshida, Y Yamashita, K Kirito, S Imagawa, Y Nakamura, K Saito, M Akutsu, K Mitani, Y Kano, N Komatsu, K Ozawa, H Mano (2001) <i>Oncogene</i> <i></i> <i></i> 20: 57 8249-8257<br/>

http://publicationslist.org/keita.kirito/refid27 2008-12-31T07:54:53Z

The mitogen-activated protein (MAP) kinase cascade is a key regulator of mammalian cell proliferation and differentiation. In this study, we examined the roles of 2 members of the MAP kinase family, extracellular signal-regulated kinase 1 (Erk1) and Erk2, in erythropoietin (EPO)-induced erythroid differentiation and thrombopoietin (TPO)-induced megakaryocytic differentiation. UT-7/GM was used as a...<br/><br/>M Uchida, K Kirito, R Shimizu, Y Miura, K Ozawa, N Komatsu (2001) <i>Int J Hematol</i> <i></i> <i></i> 73: 1 78-83<br/>

http://publicationslist.org/keita.kirito/refid28 2008-12-31T07:54:53Z

FKHRL1, a member of the Forkhead transcription factor family, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt. This molecule is a mammalian homolog of DAF-16, which plays an important role in the longevity of Caenorhabditis elegans. In this study we found that Akt and FKHRL1 proteins were detectable in highly purified normal human megakaryocytes and that these molecules wer...<br/><br/>M Tanaka, K Kirito, Y Kashii, M Uchida, T Watanabe, H Endo, T Endoh, K Sawada, K Ozawa, N Komatsu (2001) <i>J Biol Chem</i> <i></i> <i></i> 276: 18 15082-15089<br/>

http://publicationslist.org/keita.kirito/refid26 2008-12-31T07:54:53Z

Myelodysplastic syndrome (MDS) is a slowly progressing hematologic malignancy associated with a poor outcome. Despite the relatively high incidence of MDS in the elderly, differentiation of MDS from de novo acute myeloid leukemia (AML) still remains problematic. Identification of genes expressed in an MDS-specific manner would allow the molecular diagnosis of MDS. Toward this goal, AC133 surface m...<br/><br/>A Miyazato, S Ueno, K Ohmine, M Ueda, K Yoshida, Y Yamashita, T Kaneko, M Mori, K Kirito, M Toshima, Y Nakamura, K Saito, Y Kano, S Furusawa, K Ozawa, H Mano (2001) <i>Blood</i> <i></i> <i></i> 98: 2 422-427<br/>

http://publicationslist.org/keita.kirito/refid30 2008-12-31T07:54:53Z

The phosphatidylinositol 3-kinase (PI3K) signaling pathway is important for the regulation of a number of cellular responses. Serine/threonine kinase Akt (protein kinase B; PKB) is downstream of PI3K and activated by growth factors. This study found that erythropoietin (EPO) induced tyrosine phosphorylation of Akt in a time- and dose-dependent manner in EPO-dependent human leukemia cell line UT-7/...<br/><br/>Y Kashii, M Uchida, K Kirito, M Tanaka, K Nishijima, M Toshima, T Ando, K Koizumi, T Endoh, K Sawada, M Momoi, Y Miura, K Ozawa, N Komatsu (2000) <i>Blood</i> <i></i> <i></i> 96: 3 941-949<br/>

http://publicationslist.org/keita.kirito/refid29 2008-12-31T07:54:53Z

Flow cytometric, immunochemical and molecular studies were performed on leukemic blasts from a patient with minimally differentiated erythroleukemia (AML-M6v). The blasts expressed CD36 and CD71 but not lymphoid antigens, myeloid antigens, CD41 or glycophorin A. Analysis of carbohydrate antigens showed that the blasts expressed the sialyl-Tn antigen. Immunochemistry revealed that the blasts had ne...<br/><br/>K Muroi, T Tarumoto, T Akioka, K Kirito, T Nagai, T Izumi, M Nakamura, K Hatake, S Hakomori, Y Miura, K Ozawa (2000) <i>Intern Med</i> <i></i> <i></i> 39: 10 843-846<br/>

http://publicationslist.org/keita.kirito/refid35 2008-12-31T07:54:53Z

A retrospective analysis was performed on 76 consecutive elderly patients with acute leukemia aged 60 years or more (48 men, 28 women). Forty patients were 60-69 years old, 28 were 70-79 years old and 8 were > or = 80 years old. There were 55 patients with acute myelogenous leukemia (AML), 13 acute lymphoblastic leukemia (ALL) and 8 AML from myelodysplastic syndrome (MDS/AML). Patients were treate...<br/><br/>M Tabata, M Yoshida, T Izumi, C Kawano, R Kuribara, M Toshima, K Omine, M Takatoku, M Uchida, K Kirito, A Miyazato, H Takahashi, M Hoshino, Y Terui, H Tomizuka, T Otsuki, R Shimizu, J Tsunoda, K Muroi, Y Furukawa, Y Amemiya, S Imagawa, N Komatsu, T Suzuki, Y Miura (1998) <i>Rinsho Ketsueki</i> <i></i> <i></i> 39: 3 176-184<br/>

http://publicationslist.org/keita.kirito/refid33 2008-12-31T07:54:53Z

We recently determined that erythropoietin (EPO) activates 3 members of the signal transducer and activator of transcription (STAT) family, Stat1alpha, Stat3, and Stat5, in the human EPO-dependent cell lines, UT-7 and UT-7/EPO (Kirito et al, J Biol Chem 272:16507, 1997). In addition, we have shown that Stat1alpha, but not Stat3, is involved in EPO-induced cellular proliferation. In this study, we ...<br/><br/>K Kirito, M Uchida, M Takatoku, K Nakajima, T Hirano, Y Miura, N Komatsu (1998) <i>Blood</i> <i></i> <i></i> 92: 2 462-471<br/>

http://publicationslist.org/keita.kirito/refid34 2008-12-31T07:54:53Z

UT-7 is a human megakaryoblastic leukemia cell line with absolute dependence on interleukin-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), or erythropoietin (EPO) for growth and survival. Among its sublines, UT-7/GM, which remains undifferentiated in the presence of GM-CSF, has a bipotency showing differentiation into erythroid or megakaryocytic cell lineages in the presence of EPO ...<br/><br/>Y Miura, K Kirito, N Komatsu (1998) <i>Acta Haematol</i> <i></i> <i></i> 99: 3 180-184<br/>

http://publicationslist.org/keita.kirito/refid31 2008-12-31T07:54:53Z

We examined expression of the erythroid-associated genes GATA-1 and erythropoietin receptor (EPOR) in primary leukemia using the reverse transcriptase-polymerase chain reaction (RT-PCR). GATA-1 and EPOR mRNAs were detectable in all cases of erythroleukemia (French-American-British classification: M6) or early erythroblastic leukemia. In all other leukemia cases, including M2 through M5, stem cell ...<br/><br/>N Komatsu, K Kirito, T Izumi, M Eguchi, Y Miura (1998) <i>Exp Hematol</i> <i></i> <i></i> 26: 12 1148-1154<br/>

http://publicationslist.org/keita.kirito/refid32 2008-12-31T07:54:53Z

Thrombopoietin (TPO) acts on megakaryopoiesis and erythropoiesis in vitro and in vivo. We isolated a novel subline, UT-7/GMT, from the human leukemia cell line UT-7/GM (N. Komatsu, et al., Blood, 89: 4021-4033, 1997). A small population of UT-7/GM cells positively stained for hemoglobin (Hb) after a 7-day exposure to TPO. More than 50% of TPO-treated UT-7/GMT cells positively stained for Hb. Using...<br/><br/>M Yamada, N Komatsu, K Kirito, Y Kashii, H Tomizuka, K Okada, T Endo, Y Fukumaki, K Shinjo, K Abe, Y Miura (1998) <i>Cell Growth Differ</i> <i></i> <i></i> 9: 6 487-496<br/>

http://publicationslist.org/keita.kirito/refid37 2008-12-31T07:54:53Z

UT-7 is a human megakaryoblastic leukemia cell line with absolute dependence on interleukin-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), or erythropoietin (EPO) for growth and survival. We isolated a novel subline, UT-7/GM after long-term culture of UT-7 with GM-CSF. The hemoglobin concentration and gamma-globin and EPO-receptor mRNA levels were significantly higher in EPO-treated...<br/><br/>N Komatsu, K Kirito, R Shimizu, M Kunitama, M Yamada, M Uchida, M Takatoku, M Eguchi, Y Miura (1997) <i>Blood</i> <i></i> <i></i> 89: 11 4021-4033<br/>

http://publicationslist.org/keita.kirito/refid38 2008-12-31T07:54:53Z

To understand the regulatory mechanism of erythropoietin (EPO) receptor (EPOR) gene expression, the effect of EPO on the steady-state level of EPOR mRNA was examined using the human EPO-dependent cell line UT-7 as a model system. We found that the treatment of UT-7 cells with EPO resulted in a transient decrease of the EPOR mRNA level. This transient downregulation was also induced by stimulation ...<br/><br/>N Komatsu, K Kirito, Y Kashii, Y Furukawa, J Kikuchi, N Suwabe, M Yamamoto, Y Miura (1997) <i>Blood</i> <i></i> <i></i> 89: 4 1182-1188<br/>

http://publicationslist.org/keita.kirito/refid36 2008-12-31T07:54:53Z

The Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathway is an important signaling pathway of interferons and cytokines. We examined the activation of STAT proteins induced by interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), or erythropoietin (EPO) using the human leukemia cell line, UT-7, which requires these cytokines for growth. IL...<br/><br/>K Kirito, M Uchida, M Yamada, Y Miura, N Komatsu (1997) <i>J Biol Chem</i> <i></i> <i></i> 272: 26 16507-16513<br/>

http://publicationslist.org/keita.kirito/refid39 2008-12-31T07:54:53Z

The mechanism of interleukin-3 (IL-3) independent cell growth and of IL-3-associated ganglioside expression was analysed using the IL-3 dependent murine myelogenous leukaemia cell line NFS60-I7 and IL-3 gene-transfected sublines. The transfected cell lines showed autonomous cell growth, tumorigenicity, and IL-3 associated ganglioside GD1a expression in spite of their IL-3 production. While the par...<br/><br/>M Nakamura, K Kirito, A Tsunoda, K Hara, Y Furukawa, M Saito (1996) <i>Glycoconj J</i> <i></i> <i></i> 13: 2 255-261<br/>

http://publicationslist.org/keita.kirito/refid40 2008-12-31T07:54:53Z

Murine interleukin-3 (IL-3)-associated expression of gangliosides has been investigated using a gene transfection technique. A murine IL-3 cDNA was introduced into the parental NFS60-17 cells that was exclusively dependent on IL-3. We analyzed the glycosphingolipids from the parental cells and the transfected cells by fast atom bombardment mass spectrometry analyses and/or immunostaining technique...<br/><br/>A Tsunoda, M Nakamura, K Kirito, K Hara, M Saito (1995) <i>Biochemistry</i> <i></i> <i></i> 34: 29 9356-9367<br/>

http://publicationslist.org/keita.kirito/refid41 2008-12-31T07:54:53Z

We described a case of adult T cell leukemia (ATL) not associated with human T-cell leukemia virus type I (HTLV-I), a clinical entity that was first reported by Shimoyama et al. A 79-year-old male was admitted with anorexia and fever in October, 1989. Physical examination revealed marked hepatosplenomegaly and superficial lymphadenopathies. Hematological examination revealed marked leukocytosis (1...<br/><br/>K Kirito, H Shindou, N Chiba, K Tobinai, M Shimoyama, T Kinoshita (1993) <i>Rinsho Ketsueki</i> <i></i> <i></i> 34: 12 1550-1555<br/>

http://publicationslist.org/keita.kirito/refid42 2008-12-31T07:54:53Z

A 65-year-old man, who had been treated for multiple myeloma (MM) since 1986, was admitted because of loss of consciousness in September 1989. An electrocardiogram taken just before admission showed a sinus arrest, junctional escaped rhythm, and marked bradycardia. The diagnosis of sick sinus syndrome (SSS) was made. Soon a temporary pacemaker was inserted, and the dyspnea ameliorated. However on ...<br/><br/>K Kirito, H Shindo, N Chiba, T Koyama, H Yokoyama (1992) <i>Rinsho Ketsueki</i> <i></i> <i></i> 33: 4 532-536<br/>

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The role of acidic glycosphingolipids in cell growth and differentiation was investigated using the multipotent leukemia cell line K562. When GM3 was added to cell culture media, the growth of K562 cells was remarkably inhibited and the cells were shown to have megakaryocytoid morphology. Ultrastructural study demonstrated that K562 cells treated with GM3 had platelet peroxidase-positive structure...<br/><br/>M Nakamura, K Kirito, J Yamanoi, T Wainai, H Nojiri, M Saito (1991) <i>Cancer Res</i> <i></i> <i></i> 51: 7 1940-1945<br/>

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K Kirito, N Chiba (1991) <i>Nippon Naika Gakkai Zasshi</i> <i></i> <i></i> 80: 11 1818-1820<br/>

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Neolacto-series gangliosides having linear poly-N-acetyl-lactosaminyl oligosaccharide structure have been demonstrated to be increased characteristically during granulocytic differentiation of human promyelocytic leukemia cell line HL-60 cells induced by dimethyl sulfoxide or retinoic acid (Nojiri, H., Takaku, F., Tetsuka, T., Motoyoshi, K., Miura, Y., and Saito, M. (1984) Blood 64, 534-541). When...<br/><br/>H Nojiri, S Kitagawa, M Nakamura, K Kirito, Y Enomoto, M Saito (1988) <i>J Biol Chem</i> <i></i> <i></i> 263: 16 7443-7446<br/>