http://publicationslist.org/data/kristen.moffat/atom.xml Kristen Moffathttp://publicationslist.org/kristen.moffat$basepathfavicon.icoRecent additions to Kristen Moffat's PublicationsList.org pagehttp://publicationslist.org/publications.png2012-05-08T18:04:38Z http://publicationslist.org/kristen.moffat/refid2 2012-05-08T18:04:08Z

The debilitating effects of rotator cuff tears and the high incidence of failure associated with current grafts underscore the clinical demand for functional solutions for tendon repair and augmentation. To address this challenge, we have designed a poly(lactide-co-glycolide) (PLGA) nanofiber-based scaffold for rotator cuff tendon tissue engineering. In addition to scaffold design and characteriza...<br/><br/>Kristen L Moffat, Anne S-P Kwei, Jeffrey P Spalazzi, Stephen B Doty, William N Levine, Helen H Lu (2009) <i>Tissue Eng Part A</i> <i></i> <i></i> 15: 1 115-126<br/>

http://publicationslist.org/kristen.moffat/refid1 2012-05-08T18:04:08Z

Interface tissue engineering is a promising new strategy aimed at the regeneration of tissue interfaces and ultimately enabling the biological fixation of soft tissue grafts used in orthopedic repair and sports medicine. Many ligaments and tendons with direct insertions into subchondral bone exhibit a complex enthesis consisting of several distinct yet continuous regions of soft tissue, noncalcifi...<br/><br/>Kristen L Moffat, I-Ning Elaine Wang, Scott A Rodeo, Helen H Lu (2009) <i>Clin Sports Med</i> <i></i> <i></i> 28: 1 157-176<br/>

http://publicationslist.org/kristen.moffat/refid3 2012-05-08T18:04:08Z

Soft tissues such as ligaments and tendons integrate with bone through a fibrocartilaginous interface divided into noncalcified and calcified regions. This junction between distinct tissue types is frequently injured and not reestablished after surgical repair. Its regeneration is also limited by a lack of understanding of the structure-function relationship inherent at this complex interface. The...<br/><br/>Kristen L Moffat, Wan-Hsuan S Sun, Paul E Pena, Nadeen O Chahine, Stephen B Doty, Gerard A Ateshian, Clark T Hung, Helen H Lu (2008) <i>Proc Natl Acad Sci U S A</i> <i></i> <i></i> 105: 23 7947-7952<br/>

http://publicationslist.org/kristen.moffat/refid4 2012-05-08T18:04:08Z

Biological fixation of soft tissue-based grafts for anterior cruciate ligament (ACL) reconstruction poses a major clinical challenge. The ACL integrates with subchondral bone through a fibrocartilage enthesis, which serves to minimize stress concentrations and enables load transfer between two distinct tissue types. Functional integration thus requires the reestablishment of this fibrocartilage in...<br/><br/>Jeffrey P Spalazzi, Moira C Vyner, Matthew T Jacobs, Kristen L Moffat, Helen H Lu (2008) <i>Clin Orthop Relat Res</i> <i></i> <i></i> 466: 8 1938-1948<br/>

http://publicationslist.org/kristen.moffat/refid6 2012-05-08T18:04:08Z

Biological fixation of orthopedic soft tissue grafts to bone poses a significant clinical challenge. The clinical success of soft tissue-based grafts for anterior cruciate ligament (ACL) reconstruction is limited by the lack of functional graft integration with subchondral bone. Soft tissues such as the ACL connect to subchondral bone via a complex interface whereby three distinct tissue regions (...<br/><br/>Jeffrey P Spalazzi, Stephen B Doty, Kristen L Moffat, William N Levine, Helen H Lu (2006) <i>Tissue Eng</i> <i></i> <i></i> 12: 12 3497-3508<br/>

http://publicationslist.org/kristen.moffat/refid5 2012-05-08T18:04:08Z

The anterior cruciate ligament (ACL) connects the femur to the tibia through direct insertion sites and functions as the primary restraint to anterior tibial translation. The ACL-to-bone insertion sites exhibit a complex structure consisting of four zones of varied cellular and matrix components, consisting of ligament, non-mineralized fibrocartilage, mineralized fibrocartilage and bone, which all...<br/><br/>Kristen L Moffat, Wan-Hsuan S Sun, Nadeen O Chahine, Paul E Pena, Stephen B Doty, Clark T Hung, Gerard A Ateshian, Helen H Lu (2006) <i>Conf Proc IEEE Eng Med Biol Soc</i> <i></i> <i></i> 1: 2366-2369<br/>

http://publicationslist.org/kristen.moffat/refid7 2012-05-08T18:04:08Z

In this study amino-terminated poly(ethylene glycol) (PEG-diamine) hydrogels were crosslinked with genipin, a chemical naturally derived from the gardenia fruit. Dissolution, swelling, and PEG-genipin release properties were determined. The dissolution studies indicated that the hydrogels are water soluble, and that the dissolution rate was concentration, mass, and temperature dependent. The disso...<br/><br/>Kristen L Moffat, Kacey G Marra (2004) <i>J Biomed Mater Res B Appl Biomater</i> <i></i> <i></i> 71: 1 181-187<br/>