http://publicationslist.org/data/lalit.sehgal/atom.xml Lalit Sehgalhttp://publicationslist.org/lalit.sehgal$basepathfavicon.icoRecent additions to Lalit Sehgal's PublicationsList.org pagehttp://publicationslist.org/publications.png2012-06-17T18:26:12Z http://publicationslist.org/lalit.sehgal/refid9 2012-06-17T18:25:56Z

This protocol describes a technique for the generation of transgenic mice by in-vivo manipulation of spermatogonial stem cells (SSCs) with a high rate of success. In this study SSCs in pre-pubescent animals were infected in vivo with recombinant lentiviruses expressing EGFP-f and mated with normal females. All male pre-founder mice produced transgenic pups with an overall success rate of over 60%....<br/><br/> Lalit Sehgal, Rahul Thorat, Nileema Khapare, Amitabha Mukhopadhaya, Mugdha Sawant & Sorab Dalal (2012) <i>Nature Protocol Exchange</i> : <br/>

http://publicationslist.org/lalit.sehgal/refid7 2012-01-24T18:38:12Z

BACKGROUND: Fascin is a globular actin cross-linking protein, which plays a major role in forming parallel actin bundles in cell protrusions and is found to be associated with tumor cell invasion and metastasis in various type of cancers including oral squamous cell carcinoma (OSCC). Previously, we have demonstrated that fascin regulates actin polymerization and thereby promotes cell motility i...<br/><br/>Alam H, Bhate AV, Gangadaran P, Sawant SS, Salot S, Sehgal L, Dange PP, Chaukar DA, D'cruz AK, Kannan S, Gude R, Kane S, Dalal SN, Vaidya MM. (2012) <i>BMC Cancer</i> : <br/>

http://publicationslist.org/lalit.sehgal/refid8 2012-06-17T18:22:54Z

The desmosome anchors keratin filaments in epithelial cells leading to the formation of a tissue wide IF network. Loss of the desmosomal plaque protein plakophilin3 (PKP3) in HCT116 cells, leads to an increase in neoplastic progression and metastasis, which was accompanied by an increase in K8 levels. The increase in levels was due to an increase in the protein levels of the Phosphatase of Regener...<br/><br/>Khapare N, Kundu ST, Sehgal L, Sawant M, Priya R, Gosavi P, Gupta N, Alam H, Karkhanis M, Naik N, Vaidya MM, Dalal SN. (2012) <i>PLoS One. 2012;7(6):e38561. Epub 2012 Jun 6.</i> : <br/>

http://publicationslist.org/lalit.sehgal/refid2 2011-07-09T03:35:33Z

Lalit Sehgal, Rahul Thorat, Nileema Khapare, Amitabha Mukhopadhaya, Mugdha Sawant, Sorab N.Dalal (2011) <i>PloS One</i> 6: 7 e21975<br/>

http://publicationslist.org/lalit.sehgal/refid6 2011-11-11T07:05:47Z

Keratins are cytoplasmic intermediate filament proteins preferentially expressed by epithelial tissues in a site-specific and differentiation-dependent manner. The complex network of keratin filaments in stratified epithelia is tightly regulated during squamous cell differentiation. Keratin 14 (K14) is expressed in mitotically active basal layer cells, along with its partner keratin 5 (K5), and th...<br/><br/>Hunain Alam, Lalit Sehgal, Samrat T Kundu, Sorab N Dalal, Milind M Vaidya (2011) <i>Mol Biol Cell</i> <i></i> <i></i> 22: 21 4068-4078<br/>

http://publicationslist.org/lalit.sehgal/refid5 2011-11-11T07:02:20Z

A decrease in the levels of the desmosomal plaque protein, plakophilin3 (PKP3), leads to a decrease in desmosome size and cell-cell adhesion. To test the hypothesis that PKP3 is required for desmosome formation, the recruitment of desmosomal components to the cell surface was studied in the PKP3 knockdown clones. The PKP3 knockdown clones showed decreased cell border staining for multiple desmosom...<br/><br/>Prajakta Gosavi, Samrat T Kundu, Nileema Khapare, Lalit Sehgal, Mansi S Karkhanis, Sorab N Dalal (2011) <i>Cell Mol Life Sci</i> <i></i> <i></i> 68: 8 1439-1454<br/>